CN115023494A - 肠道内容物分离回收装置、方法及提取物 - Google Patents

肠道内容物分离回收装置、方法及提取物 Download PDF

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CN115023494A
CN115023494A CN202080074886.8A CN202080074886A CN115023494A CN 115023494 A CN115023494 A CN 115023494A CN 202080074886 A CN202080074886 A CN 202080074886A CN 115023494 A CN115023494 A CN 115023494A
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cross
microporous membrane
flow
intestinal
filter
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勾振辉
骆奇
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Qihui Biotechnology Yangzhou Co ltd
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Qihui Biotechnology Yangzhou Co ltd
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    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/02—Separating microorganisms from their culture media
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D61/00—Processes of separation using semi-permeable membranes, e.g. dialysis, osmosis or ultrafiltration; Apparatus, accessories or auxiliary operations specially adapted therefor
    • B01D61/14—Ultrafiltration; Microfiltration
    • B01D61/18—Apparatus therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D63/00—Apparatus in general for separation processes using semi-permeable membranes
    • B01D63/08—Flat membrane modules
    • B01D63/087—Single membrane modules
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D69/00—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor
    • B01D69/02—Semi-permeable membranes for separation processes or apparatus characterised by their form, structure or properties; Manufacturing processes specially adapted therefor characterised by their properties
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12M—APPARATUS FOR ENZYMOLOGY OR MICROBIOLOGY; APPARATUS FOR CULTURING MICROORGANISMS FOR PRODUCING BIOMASS, FOR GROWING CELLS OR FOR OBTAINING FERMENTATION OR METABOLIC PRODUCTS, i.e. BIOREACTORS OR FERMENTERS
    • C12M25/00—Means for supporting, enclosing or fixing the microorganisms, e.g. immunocoatings
    • C12M25/02—Membranes; Filters
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N1/00—Microorganisms, e.g. protozoa; Compositions thereof; Processes of propagating, maintaining or preserving microorganisms or compositions thereof; Processes of preparing or isolating a composition containing a microorganism; Culture media therefor
    • C12N1/20—Bacteria; Culture media therefor
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2313/00—Details relating to membrane modules or apparatus
    • B01D2313/14—Specific spacers
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2315/00—Details relating to the membrane module operation
    • B01D2315/10—Cross-flow filtration
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/026—Sponge structure
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B01D2325/02833—Pore size more than 10 and up to 100 nm
    • B—PERFORMING OPERATIONS; TRANSPORTING
    • B01—PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01D—SEPARATION
    • B01D2325/00—Details relating to properties of membranes
    • B01D2325/02—Details relating to pores or porosity of the membranes
    • B01D2325/0283—Pore size
    • B01D2325/02834—Pore size more than 0.1 and up to 1 µm
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

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  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Wood Science & Technology (AREA)
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  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Virology (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Water Supply & Treatment (AREA)
  • Immunology (AREA)
  • Sustainable Development (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Separation Using Semi-Permeable Membranes (AREA)
  • Filtration Of Liquid (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

本发明提供一种肠道内容物分离回收装置及方法，该分离回收装置包括除杂模块和目标内容物收集模块；该除杂模块除去肠道内容物的杂质部分，该除杂模块具有错流过滤结构；该目标内容物收集模块主要由微孔膜错流过滤器构成。该方法采用粗滤、错流细滤的方式除去肠道内容物中的杂质，然后采用微孔膜错流过滤器获得浓缩液，收集目标内容物。该微孔膜具有海绵状多孔结构，与错流过滤相配合，能够快速有效实现肠道内容物中的菌群的分离、回收，所分离回收的菌群干粉占初始的湿肠道内容物的百分比至少是10％‑20％，含菌量至少为1011个/1g干粉。

Description

PCT国内申请，说明书已公开。

Claims (10)

  1. PCT国内申请，权利要求书已公开。
CN202080074886.8A 2019-12-30 2020-05-14 肠道内容物分离回收装置、方法及提取物 Pending CN115023494A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2019113976946 2019-12-30
CN201911397694 2019-12-30
PCT/CN2020/090333 WO2021135037A1 (zh) 2019-12-30 2020-05-14 肠道内容物分离回收装置、方法及提取物

Publications (1)

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CN115023494A true CN115023494A (zh) 2022-09-06

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US (1) US20220306982A1 (zh)
EP (1) EP3872163A4 (zh)
JP (1) JP2023509245A (zh)
CN (1) CN115023494A (zh)
GB (1) GB2603217B (zh)
WO (1) WO2021135037A1 (zh)

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4358507B2 (ja) * 2000-12-01 2009-11-04 ミリポア・コーポレイション 多機能バリヤフィルターを備えた化学プロセスシステム
CN101973664B (zh) * 2010-09-27 2012-05-09 普罗米绿色能源(深圳)有限公司 污水处理设备、方法及其应用
JP2012147682A (ja) * 2011-01-17 2012-08-09 Daicel Corp 気体資源から有機物を製造する方法、及び装置
CN103561752B (zh) 2011-03-09 2016-04-20 明尼苏达大学评议会 用于移植结肠微生物群的组合物和方法
CN103330961B (zh) 2013-02-08 2016-06-08 南京法迈特科技发展有限公司 一种医用腔道内容物目标成分回收器械
CN204097475U (zh) 2014-09-19 2015-01-14 张蓉 一种肠道内容物目标成分提取装置
CN204079633U (zh) * 2014-09-28 2015-01-07 大连东泰有机废物处理有限公司 一种沼液浓缩预处理装置
CN105624024B (zh) 2014-10-31 2018-01-19 南京法迈特科技发展有限公司 腔道内容物中微生物分离装置
CN204411879U (zh) * 2015-01-13 2015-06-24 南京圣卡孚科技有限公司 错流过滤膜与盲端过滤膜连续分离非均相催化剂的装置
KR102066242B1 (ko) 2015-06-09 2020-01-14 리바이오틱스, 인코퍼레이티드 미생물상 복원 치료(mrt) 조성물 및 제조 방법
CN106396267A (zh) * 2016-10-21 2017-02-15 南阳市宣溢环保设备股份有限公司 畜禽养殖废水处理系统
CN108676704A (zh) * 2018-07-30 2018-10-19 骆奇 一种肠道内容物分离回收装置、方法及其产品

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JP2023509245A (ja) 2023-03-08
EP3872163A4 (en) 2022-10-26
GB2603217B (en) 2024-05-29
US20220306982A1 (en) 2022-09-29
GB202107179D0 (en) 2021-06-30
WO2021135037A1 (zh) 2021-07-08
GB2603217A (en) 2022-08-03
EP3872163A1 (en) 2021-09-01

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