CN115005198A

CN115005198A - Organ perfusion transfer system and control method

Info

Publication number: CN115005198A
Application number: CN202210771417.2A
Authority: CN
Inventors: 张亚群; 魏森; 张迪; 王涛; 王超
Original assignee: Individual
Current assignee: Individual
Priority date: 2022-06-30
Filing date: 2022-06-30
Publication date: 2022-09-06

Abstract

The invention provides an organ perfusion transfer system and a control method, wherein the system comprises: a housing; the sensor assembly is arranged on the shell; the first bin body is movably arranged in the shell; the pump mechanism is arranged in the shell, and a pipeline used for communicating a liquid inlet of an organ is arranged at a liquid outlet of the pump mechanism; the refrigeration mechanism is arranged in the shell and is used for controlling the temperature of the first bin body; the controller, the controller is installed in the casing, and sensor assembly, refrigeration mechanism and pump mechanism all are connected with the controller electricity. This system obtains multiple sensor data in the casing through sensor assembly to by controller according to sensor data control refrigeration mechanism and pump mechanism, realize the active control to the temperature in the first storehouse body, can maintain the activity of isolated organ when long-distance transit.

Description

Organ perfusion transfer system and control method

Technical Field

The invention relates to the field of medical instruments, in particular to an organ perfusion and transfer system and a control method.

Background

In order to avoid the isolated organ from losing activity due to overhigh environmental temperature in the transferring process, the related art generally sets ice blocks in the organ storage device for physical cooling, but the ice blocks are easy to melt, the cooling maintenance time is short, the active temperature control cannot be carried out, and the isolated organ cannot be transferred for a long distance.

Disclosure of Invention

The invention provides an organ perfusion transfer system and a control method, which are used for solving the defects that the isolated organ can not be transported for a long distance due to the fact that the heat preservation time is short and the temperature drop can not be actively controlled during the transfer of the isolated organ in the prior art, and maintain the activity of the isolated organ during the long-distance transfer.

The invention provides an organ perfusion transfer system, comprising:

a housing;

the sensor assembly is arranged on the shell and is used for acquiring multiple groups of sensor data;

the first bin body is movably arranged in the shell and used for storing organs and perfusate;

the pump mechanism is arranged in the shell, a pipeline used for communicating with a liquid inlet of the organ is arranged at a liquid outlet of the pump mechanism, and the pump mechanism is used for driving the perfusate to circulate in the pipeline;

the refrigeration mechanism is arranged in the shell and is used for controlling the temperature of the first bin body.

A controller mounted to the housing, the sensor assembly, the refrigeration mechanism, and the pump mechanism all electrically connected to the controller, the controller for controlling the pump mechanism and the refrigeration mechanism based on the sensor data.

According to the present invention, there is provided an organ perfusion transfer system, the refrigeration mechanism comprising:

the second bin body is sleeved outside the first bin body and used for placing a refrigerating medium;

and the semiconductor refrigerator is arranged on the inner side wall of the second bin body and is electrically connected with the controller.

According to the present invention, there is provided an organ perfusion transfer system, further comprising:

a fan mounted to the housing, the fan for exhausting internal heat of the housing.

According to the present invention there is provided an organ perfusion transfer system, the pump mechanism comprising:

and the valve is used for controlling the flowing state of the perfusate and is electrically connected with the controller.

the filter is installed in the first bin body and used for filtering impurities in the perfusate.

the communicator component is arranged on the shell, the communicator is in communication connection with external electronic equipment, the communicator is electrically connected with the controller, and the communicator is used for manually interacting with the external electronic equipment.

the display, the display install in the casing, sensor subassembly with the controller all with the display electricity is connected, the display is used for showing sensor data and alarm information.

the memory is arranged on the shell and electrically connected with the controller, and the memory is used for storing the sensor data and the alarm information.

According to the present invention there is provided an organ perfusion transfer system, the sensor assembly comprising:

the temperature sensor is arranged on the first bin body and is used for acquiring first temperature data of the first bin body and second temperature data of the perfusate;

the bubble sensor is arranged on the pipeline and used for collecting bubble data in the pipeline;

the flow sensor is arranged on the pipeline and used for acquiring flow data of the perfusate flowing in the pipeline;

the pressure sensor is arranged on the pipeline and used for acquiring pressure data of the perfusate during circulation in the pipeline.

a power source, power movable mounting in the casing, the power is used for right organ perfusion transfer system supplies power.

The invention also provides a control method of the organ perfusion transfer system, which comprises the following steps:

setting initialization parameters of the sensor assembly in case of determining the pre-perfusion;

under the condition that the pre-perfusion is finished and the organ is loaded into the first bin body, conveying perfusate to the organ and collecting data of a plurality of groups of sensors;

controlling the temperature of the first cartridge body within a target temperature range based on the plurality of sets of sensor data.

The present invention also provides a non-transitory computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements an organ perfusion transport system method as described in any one of the above.

The invention also provides a computer program product comprising a computer program which, when executed by a processor, implements the organ perfusion transport system method as described in any one of the above.

According to the organ perfusion transfer system and the control method provided by the invention, the data of various sensors in the shell are acquired through the sensor assembly, and the controller controls the refrigerating mechanism and the pump mechanism according to the data of the sensors, so that the temperature of the first cabin body and the temperature of the perfusate are actively controlled, and the isolated organ can be in a target temperature range to keep the activity of the isolated organ during long-distance transfer.

Drawings

In order to more clearly illustrate the technical solutions of the present invention or the prior art, the drawings needed for the description of the embodiments or the prior art will be briefly described below, and it is obvious that the drawings in the following description are some embodiments of the present invention, and those skilled in the art can also obtain other drawings according to the drawings without creative efforts.

FIG. 1 is a schematic structural diagram of an organ perfusion transport system provided by the present invention;

FIG. 2 is a second schematic structural diagram of the organ perfusion transport system provided by the present invention;

FIG. 3 is a schematic flow chart of a control method of the organ perfusion transport system provided by the present invention;

fig. 4 is a second schematic flow chart of the control method of the organ perfusion transport system provided by the invention.

Reference numerals are as follows:

100: a housing; 110: a sensor assembly; 111: a temperature sensor;

112: a bubble sensor; 113: a flow sensor; 114: a pressure sensor;

120: a first bin body; 130: a pump mechanism; 131: a valve;

140: a refrigeration mechanism; 141: a second bin body; 142: a semiconductor refrigerator;

150: a controller; 160: a fan; 170: a filter;

180: a communicator; 190: a display; 1100: a memory;

1111: a power interface; 1112: a battery; 1120: a pipeline.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention clearer, the technical solutions of the present invention will be clearly and completely described below with reference to the accompanying drawings, and it is obvious that the described embodiments are some, but not all embodiments of the present invention. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.

In the description of the embodiments of the present invention, it should be noted that the terms "upper", "lower", "inner", "outer", and the like indicate orientations or positional relationships based on orientations or positional relationships shown in the drawings, which are merely for convenience of description of the embodiments of the present invention and for simplification of description, but do not indicate or imply that the device or element referred to must have a specific orientation, be configured and operated in a specific orientation, and thus, should not be construed as limiting the embodiments of the present invention.

In the description of the embodiments of the present invention, it should be noted that, unless explicitly stated or limited otherwise, the terms "connected" and "connected" are to be interpreted broadly, and may be, for example, fixedly connected, detachably connected, or integrally connected; the connection can be mechanical connection, electrical connection, wired communication connection or wireless communication connection; may be directly connected or indirectly connected through an intermediate. Specific meanings of the above terms in the embodiments of the present invention may be understood as specific cases by those of ordinary skill in the art.

In the description herein, references to the description of the term "one embodiment," "some embodiments," "an example," "a specific example," or "some examples," etc., mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of an embodiment of the invention. In this specification, the schematic representations of the terms used above are not necessarily intended to refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples. Furthermore, various embodiments or examples and features of different embodiments or examples described in this specification can be combined and combined by one skilled in the art without contradiction.

The organ perfusion transport system of the present invention is described below with reference to fig. 1-2.

As shown in fig. 1, the organ perfusion transport system comprises: a housing 100, a sensor assembly 110, a first cartridge body 120, a pump mechanism 130, a refrigeration mechanism 140, and a controller 150.

In this embodiment, the housing 100 is a support structure that carries the sensor assembly 110, the first cartridge body 120, the pump mechanism 130, the refrigeration mechanism 140, and the controller 150, which can be mounted inside the housing 100.

In some embodiments, the housing 100 may be a portable case or a non-portable case, such as a shipping case.

In some embodiments, the material of the housing 100 may be a composite material, or may be a metal material, such as an alloy.

Wherein the sensor assembly 110 is mounted to the housing 100 for acquiring multiple sets of sensor data.

In some embodiments, the sensor assembly 110 includes a variety of sensor data, for example, the sensor assembly 110 may include a temperature sensor 111, a pressure sensor 114, a flow sensor 113, a humidity sensor, a thermal sensor, a bubble sensor 112, and an energy consumption sensor for acquiring temperature data within the housing 100 or the first cartridge body 120, pressure data of the liquid within the pump mechanism 130, flow data of the perfusate, and the like, respectively.

In this embodiment, the plurality of sensors in the pressure sensor 114 assembly 110 may be distributed within or about the area within the housing 100 to collect more accurate sensor data.

The first cartridge body 120 is movably installed at the casing 100 for storing organs and perfusate.

In some embodiments, the first cartridge body 120 is a container that holds the organ and the perfusate.

In this embodiment, the organ may be an isolated organ to be transplanted or preserved in a human or animal, and the organ may be a kidney, heart, or the like of the human or animal.

In this embodiment, the perfusate is used to preserve the activity of the isolated organ, for example, the perfusate may be uw (the University of Wisconsin solution) solution or HTK (Histine-Tryptophan-Ketoglutate solution) solution, etc.

In some embodiments, the first chamber body 120 is detachably connected to the casing 100, for example, the first chamber body 120 can be slidably mounted on an ice trough of the casing 100, so that the first chamber body 120 can be separated from the ice trough after the organ transfer is finished, and a new isolated organ can be contained after the new first chamber body 120 is replaced, so that the organ perfusion transfer system can be recycled, thereby saving the cost.

The pump mechanism 130 is mounted to the housing 100, and a fluid outlet of the pump mechanism 130 is mounted with a pipeline 1120 for communicating with a fluid inlet of the organ, for driving the perfusate to circulate in the pipeline 1120.

In some embodiments, the pumping mechanism 130 may drive the perfusion fluid in the line 1120 to circulate inside and outside the isolated organ for ensuring viability of the isolated organ.

In this embodiment, the fluid inlet of the organ may be an arterial vessel of the organ, for example, where the organ is a kidney, the fluid inlet of the kidney is a renal arterial vessel.

In this embodiment, the outlet of the pump mechanism 130 is connected to the renal artery via a line 1120, the inlet of the pump mechanism 130 extends into the perfusate contained in the first chamber body 120, the perfusate can be delivered from the inlet of the pump mechanism 130, the outlet of the pump mechanism 130 and the line 1120 into the kidney, and the pump mechanism 130 can also pump the perfusate out of the organ via the renal artery and deliver the perfusate back to the first chamber body 120 via the line 1120, the outlet of the pump mechanism 130 and the inlet of the pump mechanism 130 in sequence.

In this embodiment, the pipeline 1120 may be a hard pipe or a hose.

In some embodiments, the pump mechanism 130 can also adjust the flow rate of the perfusate in the tubing 1120 and the pressure of the perfusate on the tubing 1120, thereby adjusting the flow rate of the perfusate in the tubing 1120.

A refrigeration mechanism 140 is mounted to the housing 100 for controlling the temperature of the first cartridge body 120.

In some embodiments, the refrigeration mechanism 140 is mounted within the casing 100 proximate to the first cartridge body 120 for cooling the first cartridge body 120.

In this embodiment, the refrigeration structure may be a semiconductor refrigerator 142 that performs electronic refrigeration in combination with a low-temperature material such as ice water, and the refrigeration structure may perform circulation refrigeration for a long time (not less than 72 hours).

In this embodiment, the semiconductor cooler 142 can be used to deliver cool air to the ambient air periodically to maintain the ambient temperature, or continuously.

In some embodiments, the refrigeration structure may also be an electric refrigeration or other physical refrigeration different from ice block cooling, etc. by using a PID regulator.

The sensor assembly 110, the refrigeration mechanism 140, and the pump mechanism 130 are all electrically connected to a controller 150 for controlling the pump mechanism 130 and the refrigeration mechanism 140 based on sensor data.

A controller 150 is mounted within the housing 100 and the sensor assembly 110, the refrigeration mechanism 140, and the pump mechanism 130 are all electrically connected to the controller 150, the controller 150 being configured to control the pump mechanism 130 and the refrigeration mechanism 140 based on sensor data.

In some embodiments, after receiving the various sensor data collected by the sensor assembly 110, the controller 150 can send a temperature control command, a perfusate pressure and a flow rate control command to the refrigeration mechanism 140 and the pump mechanism 130, respectively, so as to control the refrigeration mechanism 140 to cool the first cartridge body 120 and control the flow rate or pressure of the perfusate in the pipeline 1120, thereby realizing active adjustment of the temperature of the first cartridge body 120.

In some embodiments, the sensor assembly 110 can also send the temperature of the perfusion fluid to the controller 150, and the controller 150 sends a corresponding control instruction to the refrigeration mechanism 140 according to the temperature data of the perfusion fluid, so as to control the refrigeration mechanism 140 to cool the perfusion fluid.

According to the organ perfusion transfer system provided by the embodiment of the invention, the sensor assembly 110 acquires various sensor data in the shell 100, and the controller 150 controls the refrigerating mechanism 140 and the pump mechanism 130 according to the sensor data, so that the temperature of the first chamber body 120 and the temperature of the perfusate can be actively controlled, and the isolated organ can be in a target temperature range to keep the activity thereof during long-distance transfer.

In some embodiments, the refrigeration mechanism 140 includes: a second cartridge body 141, a semiconductor cooler 142.

In this embodiment, a refrigeration medium, such as ice water, can be stored in the second bin body 141, one or more semiconductor refrigerators 142 are installed on the inner wall of the second bin body 141, the semiconductor refrigerators 142 can perform rapid refrigeration in an energized state, and the number of the installed semiconductor refrigerators 142 can be set by user according to actual requirements.

In this embodiment, the material of the second cartridge body 141 can be metal or the like with good cold conducting performance.

The second bin body 141 is sleeved outside the first bin body 120; the semiconductor cooler 142 is mounted on the inner side wall of the second bin body 141, and the semiconductor cooler 142 is electrically connected with the controller 150.

In some embodiments, the second bin body 141 can be a cylindrical structure and is installed around the outer side of the first bin body 120, the second bin body 141 is not in direct contact with the first bin body 120, and the second bin body 141 is filled with ice and water low-temperature materials.

In some embodiments, the distance between the outer sidewall of the second cartridge body 141 facing the first cartridge body 120 and the outer sidewall of the first cartridge body 120 can be in the range of 0.1cm to 5cm, and the semiconductor cooler 142 mounted on the outer sidewall of the second cartridge body 141 can rapidly guide the cool air to the first cartridge body 120 for cooling until the temperature of the first cartridge body 120 is in the target temperature range, which can be customized according to actual needs, for example, the target temperature range can be 4 ℃ to 8 ℃.

In this embodiment, the first bin body 120 can be movably mounted on an ice groove in the housing 100, the second bin body 141 is sleeved outside the first bin body 120, and the distance between the outer sidewall of the second bin body 141 facing the first bin body 120 and the outer sidewall of the first bin body 120 is 1cm, the plurality of semiconductor refrigerators 142 are mounted on the outer inner wall of the second bin body 141, and the semiconductor refrigerators 142 are electrically connected with the controller 150; when the sensor detects that the temperature in the first bin body 120 is higher than 4-8 ℃, the controller 150 sends a control instruction to the semiconductor refrigerator 142 to refrigerate, and the temperature of the first bin body 120 is reduced to be within the range of 4-8 ℃ to maintain the activity of the isolated organ.

According to the organ perfusion transfer system provided by the embodiment of the invention, the second bin body 141 is arranged at the outer side of the first bin body 120 in the shell 100, and the semiconductor refrigerator 142 and the ice water are installed on the outer side wall of the second bin body 141 facing the first bin body 120 for rapid refrigeration, so that a stable and uniformly distributed temperature interval is provided for the isolated organ.

In some embodiments, a fan 160 is further included, the fan 160 is mounted to the housing 100, and the fan 160 is used to exhaust internal heat of the housing 100.

It should be noted that, the sensor assembly 110, the pump mechanism 130, the refrigeration mechanism 140, the controller 150, and other devices mounted on the housing 100 need to consume electric energy, and a part of the electric energy is converted into heat energy to raise the temperature in the housing 100, which is not favorable for storage and transportation of the isolated organ.

In this embodiment, a heat dissipation fan 160 may be installed on the housing 100 for exhausting heat inside the housing 100 to prevent the temperature inside the housing 100 from rising too fast.

According to the organ perfusion transfer system provided by the embodiment of the invention, the heat generated in the casing 100 can be discharged to the air in real time by installing the heat radiation fan 160 on the casing 100, so that the environment in the casing 100 is in a low temperature state.

In some embodiments, the pump mechanism 130 includes: and a valve 131 for controlling the flow state of the perfusion fluid, wherein the valve 131 is electrically connected with the controller 150.

In this embodiment, the valve 131 is mounted on the pump mechanism 130 and can be used to control the flow direction of the perfusate in the pipeline 1120, for example, the perfusate in the first cartridge body 120 can be delivered to the kidney through the pipeline 1120 and the renal artery by opening and closing the valve 131, and the perfusate in the kidney can be pumped back to the first cartridge body 120 through the renal artery and the pipeline 1120.

In some embodiments, the valve 131 is electrically connected to the controller 150 and can also be used to regulate the flow and pressure of the perfusion fluid in the tubing 1120, thereby controlling the flow rate of the perfusion fluid in the tubing 1120.

In this embodiment, when perfusing the organ, the controller 150 sends a command to the valve 131 to open the pipeline 1120, and the pump mechanism 130 circulates the perfusate between the first cartridge body 120 and the organ through the pipeline 1120, and the valve 131 receives a command from the controller 150 to adjust the flow rate and pressure of the perfusate, so as to control the flow rate, pressure or resistance of the perfusate in the pipeline 1120.

In some embodiments, during the priming process, the controller 150 sends an instruction to the valve 131 to open the tubing 1120 and inputs the perfusion fluid in the first cartridge body 120 into the tubing 1120 through the pump mechanism 130 to reduce air bubbles in the tubing 1120 and flush the tubing 1120.

According to the organ perfusion transfer system provided by the embodiment of the invention, the valve 131 is arranged on the pump mechanism 130, and the controller 150 controls the opening and closing of the valve 131, so that the active control of parameters such as pressure, flow rate and resistance of perfusate in the pipeline 1120 is realized, and the activity of an organ in a perfusion process can be improved.

In some embodiments, further comprising: the filter 170, the filter 170 is installed on the first chamber body 120, and the filter 170 is used for filtering out impurities in the perfusate.

In this embodiment, a filter 170 may be installed at an opening at one or both ends of the tubing 1120 to filter out impurities or bacteria in the perfusate during perfusion to ensure that the organ is in a sterile environment.

In this embodiment, the material of the filter 170 is an antibacterial nano material.

In this embodiment, the controller 150 sends a command to the valve 131 to open the pipeline 1120, and the perfusion fluid in the first cartridge body 120 is filtered by the filter 170 through the pump mechanism 130 and then is input into the pipeline 1120, so that the pipeline 1120 can be sterilized, and air bubbles in the pipeline 1120 can be reduced.

According to the organ perfusion transfer system provided by the embodiment of the invention, the filter 170 is arranged at the circulating place of the perfusate, so that bacteria and impurities carried in the circulating process can be effectively filtered, and the activity of the isolated kidney in the perfusion process is further improved.

In some embodiments, further comprising: the communicator 180, the communicator 180 assembly is installed in the casing 100, and the communicator 180 is in communication connection with the external electronic device.

In this embodiment, the housing 100 is further provided with a communicator 180, which is capable of establishing a communication connection with an external electronic device (such as a mobile phone, a tablet, etc.) through third-party software, where the communication connection may be a bluetooth connection or a WiFi signal connection.

The communicator 180 is electrically connected with the controller 150, and the communicator 180 is used for manual interaction with an external electronic device.

In some embodiments, the controller 150 can send the received multiple sets of sensor data and other information (alarm information, instructions, etc.) obtained based on the sensor data to the external electronic device through the communicator 180, and then the external electronic device can view the sensor data or the alarm information on the corresponding human-computer interaction interface and configure and regulate physical parameters in the housing 100 according to the instructions.

In this embodiment, when the organ is perfused, the controller 150 controls the valve 131 to open and the perfusate is circulated between the first chamber body 120 and the organ through the pipe 1120 by the pump mechanism 130, the controller 150 controls the sensor assembly 110 to collect and analyze physical parameters such as temperature, flow rate, pressure or resistance in the pipe 1120 in real time, when the physical parameters exceed normal indexes, the controller 150 sends the parameters to the external electronic equipment through the communicator 180 and prompts an alarm, and after a user sees the alarm information, the external electronic equipment configures the parameters physically, for example, the controller 150 controls the valve 131 to adjust the pressure and flow rate of the perfusate, and controls the semiconductor refrigerator 142 to control the temperature of the first chamber body 120.

According to the organ perfusion transportation system provided by the embodiment of the invention, the communicator 180 is arranged on the shell 100 and is in communication connection with the external electronic equipment, so that the human-computer interaction process of the external electronic equipment and the organ perfusion transportation system can be realized, and the online configuration of various physical parameters of the first cabin body 120 by a user is realized.

In some embodiments, further comprising: a display 190.

Wherein the display 190 is installed at the housing 100, the sensor assembly 110 and the controller 150 are electrically connected, and the display 190 is used to display sensor data and alarm information.

In this embodiment, a display 190, such as a liquid crystal display, is also disposed on the housing 100.

In this embodiment, the display 190 is electrically connected to the sensor assembly 110 and the controller 150, respectively, and can receive the sets of sensor data collected by the sensor assembly 110, and can configure the sensor data on the display interface of the display 190, for example, the initial value setting of the sensor assembly 110 can be performed on the display interface of the display 190, and the sensor data collected in real time can be adjusted and changed to control various physical parameters in the first cartridge body 120.

In some embodiments, an alarm message sent by the controller 150, information about the power level of the power source, information about consumables of each device in the housing 100, and the like may also be displayed on the display interface of the display 190.

In this embodiment, after the switch of the display 190 is turned on, the display interface of the display 190 displays the power information of the power supply and the initial information of the environment inside the casing 100, when the organ is perfused, the display interface can display the loss information of each device inside the casing 100, each physical parameter of the first cabin 120 and abnormal information (such as a rapid rise in the temperature inside the casing), and the user can configure each physical parameter inside the first cabin 120 through the display screen to maintain the stability of the temperature inside the first cabin 120, thereby ensuring the activity of the organ during perfusion.

According to the organ perfusion transfer system provided by the embodiment of the invention, the display 190 is arranged on the shell 100, so that the change condition of each physical parameter of the controller 150 in the perfusion process can be controlled in real time, and the activity of the organ in perfusion transfer is ensured.

In some embodiments, further comprising: and a memory 1100, the memory 1100 being mounted to the housing 100, the memory 1100 being electrically connected to the controller 150, the memory 1100 being used to store sensor data and alarm information.

In this embodiment, the memory 1100 is electrically connected to the controller 150, and the memory 1100 can store various physical parameters during the perfusion transfer process after receiving the instruction from the controller 150.

In this embodiment, when physical parameters such as temperature, pressure in the tubing 1120, flow rate of perfusion fluid, etc. change in the first cartridge body 120, the controller 150 may control the memory 1100 to store the changed data so as to predict and configure the physical parameters at a future time in combination with the stored historical data.

According to the organ perfusion transfer system provided by the embodiment of the invention, the display memory 1100 is arranged on the shell 100, so that various physical parameters in the first cabin body 120 can be stored in real time, and the corresponding parameters at the future moment can be predicted or regulated.

In some embodiments, the sensor assembly 110 includes: the temperature sensor 111, the temperature sensor 111 is installed on the first bin body 120, and the temperature sensor 111 is used for acquiring first temperature data of the first bin body 120 and second temperature data of the perfusate; the bubble sensor 112, the bubble sensor 112 is installed in the pipeline 1120, and the bubble sensor 112 is used for collecting bubble data in the pipeline 1120; the flow sensor 113, the flow sensor 113 is installed on the pipeline 1120, the flow sensor 113 is used for collecting the flow data when the perfusate circulates in the pipeline 1120; the pressure sensor 114, the pressure sensor 114 is installed in the pipeline 1120, and the pressure sensor 114 is used for collecting pressure data when the perfusate circulates in the pipeline 1120.

In this embodiment, the sensor assembly 110 may include a plurality of different types of sensors for acquiring a plurality of physical parameters (such as temperature, pressure in the pipeline, flow rate of the perfusate, etc.) in the casing 100, and the controller 150 sends different control instructions according to the control parameters, so as to regulate and control physical quantities such as ambient temperature, flow rate of the perfusate, pressure in the pipeline 1120, bubbles, and flow rate in the casing 100.

In this embodiment, the temperature sensor 111 may collect temperature data in the first bin body 120, may also collect temperature data of the perfusate, and may also collect temperature data of the entire environment in the casing 100, the temperature sensor 111 is electrically connected to the controller 150, and may send the collected temperature data to the controller 150, and the controller 150 actively regulates and controls the temperature of the first bin body 120 or the perfusate according to a set target temperature range, which may be 4 ℃ to 8 ℃.

In this embodiment, the bubble sensor 112 is used to detect the bubble data in the pipeline 1120, for example, when performing pre-filling on the pipeline 1120, the bubble data in the pipeline 1120 may be collected before and after the pre-filling process, the bubble sensor 112 is electrically connected to the controller 150, the collected bubble number may be sent to the controller 150, and the controller 150 may actively regulate and control the bubble number in the pipeline 1120 to be reduced to a suitable range.

In this embodiment, the flow sensor 113 is configured to collect flow data of the perfusate in the pipeline 1120, such as a flow rate or a flow rate of the perfusate flowing through the pipeline 1120, the pressure sensor 114 is configured to collect pressure data of the perfusate flowing through the pipeline 1120, and also can acquire resistance data received when the perfusate flows through the pipeline 1120, and the like, both the flow sensor 113 and the pressure sensor 114 are electrically connected to the controller 150, and can send the collected flow data and pressure data to the controller 150, and the controller 150 controls the valve 131 on the pump mechanism 130 to regulate the flow rate or the flow rate of the perfusate in the pipeline 1120.

According to the organ perfusion transfer system provided by the embodiment of the invention, the plurality of sensors are arranged in the shell 100 and used for acquiring data such as different temperatures, pressures, liquid flow rates and the like and sending the data to the controller 150 for processing, so that active regulation and control on a plurality of parameters (the temperature, the pressure, the flow rates and the like of perfusate) related to the isolated organ can be realized, and the activity of the organ during perfusion is improved.

In some embodiments, further comprising: and a power supply movably mounted in the housing 100, the power supply being configured to supply power to the organ perfusion transfer system.

In this embodiment, the power supply includes a power interface 1111 and a battery 1112, and the power supply supplies power to the housing 100, the sensor assembly 110, the pump mechanism 130, the refrigeration mechanism 140, and the controller 150 through the power interface 1111 to ensure proper operation thereof.

In this embodiment, the battery 1112 in the power supply for supplying power may be a removable battery, facilitating ready replacement without a charging device.

In the embodiment shown in fig. 2, the organ perfusion transfer system comprises a control and interaction unit, a sensing feedback unit, an execution unit, a physical support unit and a power supply; the control and interaction unit includes a controller 150, a memory 1100, a communicator 180, a display 190 and a human-computer interaction interface displayed on an external electronic device, the sensing and feedback unit includes a temperature sensor 111, a bubble sensor 112, a flow sensor 113 and a pressure sensor 114, the execution unit includes a pump mechanism 130, a valve 131, a semiconductor refrigerator 142 and a fan 160, the physical support unit includes a first cartridge body 120, a second cartridge body 141, a pipeline 1120, a filter 170 and a housing 100, the power supply includes a power interface 1111 and a battery 1112, and the units can individually or jointly perform a function of actively regulating and controlling various physical parameters in the organ perfusion and transportation process, thereby maintaining the activity of the organ in the perfusion and transportation process, which is not repeated in this embodiment.

In an embodiment shown in fig. 3, the present invention further provides a method of controlling an organ perfusion transfer system, comprising:

in the case of a determination of pre-perfusion, initialization parameters of the sensor assembly 110 are set, step 310.

In this step, the pre-perfusion is prepared for organ perfusion, and the initial parameters of the sensor assembly 110 can be configured via the human-computer interface or the display 190 to ensure that the first cartridge body 120 has a stable internal environment when the pre-perfusion is performed.

In the embodiment of fig. 4, before performing pre-irrigation, steps such as preparation, checking the device, setting initial parameters, etc. are required; wherein the preparation work includes: preparing a sterile operation field and instruments, and respectively placing perfusate and ice water in the first bin body 120 and the second bin body 141; the inspection apparatus includes: firstly, checking the sealing performance of the shell 100, whether equipment and accessories in the shell 100 are complete, then checking whether a system normally operates and whether electric quantity is sufficient when the system is electrified, and checking whether a human-computer interaction program is normally started and whether the first cabin body 120 and the second cabin body 141 are well sealed; after the preparation and inspection operations are completed, the external electronic device or display 190 can be used to set the initial values of the physical parameters in the first chamber 120, such as the temperature, pressure, flow rate, and resistance index default values in the first chamber 120.

Step 320, under the condition that the pre-perfusion is completed and the organ is loaded into the first cartridge body 120, the perfusate is delivered to the organ and a plurality of sets of sensor data are acquired.

In this step, after the pre-perfusion process is finished, after the parameters in the environment of the first bin body 120 are ensured to be set, the organ can be loaded into the first bin body 120 and perfused with the perfusate, and a plurality of physical parameters in the first bin body 120 are collected in real time by a plurality of sensors in the sensor assembly 110.

In some embodiments, after the initialization parameters of the sensor assembly 110 are set, and before pre-filling pre-cooling is completed, the first cartridge body 120 needs to be pre-cooled such that the temperature within the first cartridge body 120, the temperature of the perfusion fluid, or the temperature of the second cartridge body 141 is maintained within a target temperature range.

In the embodiment of fig. 4, after the setting of the initial parameters is completed, the steps of (1) pre-refrigeration, pre-perfusion, organ loading, organ perfusion and the like are also required; wherein, the pre-cooling process is as follows: starting a temperature button on the shell 100 to confirm that the refrigeration mechanism 140 starts working and the temperature is continuously constant in a target temperature range (4 ℃ -8 ℃); the pre-perfusion process is as follows: starting a pre-filling button on the housing 100, confirming that the pump mechanism 130 starts to work, and allowing the filling fluid to flow in the pipeline 1120, wherein bubbles in the pipeline 1120 can be reduced in the pre-filling process, and the pipeline 1120 can be washed and bacteria can be filtered; the organ perfusion process is as follows: the pump mechanism 130 pumps the perfusate out of the first cartridge body 120 through the conduit 1120, and the perfusate is infused into the organ through the loop of the conduit 1120, and the perfusate re-enters the first cartridge body 120 after passing through the organ, in the process, the refrigeration mechanism 140 operates synchronously, and the temperature of the first cartridge body 120 is kept constant within the target temperature range.

The temperature of the first cartridge body 120 is controlled to be within the target temperature range based upon the plurality of sets of sensor data, step 330.

In this step, the target temperature range may be set in a user-defined manner according to actual requirements, for example, the target temperature range is 4 ℃ -8 ℃.

In the embodiment of fig. 4, after the organ perfusion is completed, the sensor assembly 110 monitors the temperature, pressure, flow rate, and resistance index in the first chamber 120 in real time, and transmits a feedback signal of the sensor data to the controller 150, and the controller 150 will send instructions to adjust the pump mechanism 130 and the refrigeration mechanism 140 according to the feedback signal and the set value, and adjust the physical parameters to the set value, so that the organ is always in the target temperature range during the perfusion transfer, thereby ensuring the activity of the organ.

In some embodiments, after the transfer of the organ and the removal of the organ from the first cartridge body 120 are completed, the first cartridge body 120, the pipeline 1120, the filter 170, etc. can be detached from the housing 100, and the other equipment inside the housing 100 can be sterilized and disinfected.

In the embodiment of fig. 4, after the organ perfusion is completed, the organ is taken out from the first chamber body 120, and then the sterilization and disinfection processes are performed on the devices in the casing 100.

According to the control method of the organ perfusion transfer system provided by the embodiment of the invention, after the examination device, the initial parameter setting and the pre-perfusion are carried out on the organ perfusion transfer system, the isolated organ can be ensured to be in a sterile environment, then the isolated organ is loaded into the organ for perfusion, and various sensor data in the first cabin body 120 are acquired, and the controller 150 realizes the active control on the temperature of the first cabin body 120 and the temperature of the perfusate according to the control of the refrigerating mechanism 140 and the pump mechanism 130, so that the isolated organ can be in a target temperature range during long-distance transfer to keep the activity of the isolated organ.

The present invention also provides a computer program product comprising a computer program, the computer program being storable on a non-transitory computer readable storage medium, the computer program, when executed by a processor, being capable of executing a method for controlling an organ perfusion transport system provided by the above-mentioned methods, the method comprising: setting initialization parameters of the sensor assembly in case of determining the pre-perfusion; under the condition that the pre-perfusion is finished and the organ is loaded into the first bin body, the perfusate is conveyed to the organ, and a plurality of groups of sensor data are collected; and controlling the temperature of the first bin body within a target temperature range based on the plurality of sets of sensor data.

The present invention also provides a non-transitory computer readable storage medium having stored thereon a computer program which, when executed by a processor, implements a method of controlling an organ perfusion transport system provided by the above-mentioned methods, the method comprising: setting initialization parameters of the sensor assembly in case of determining the pre-perfusion; under the condition that the pre-perfusion is finished and the organ is loaded into the first bin body, the perfusate is conveyed to the organ, and a plurality of groups of sensor data are collected; and controlling the temperature of the first bin body within a target temperature range based on the plurality of sets of sensor data.

The above-described embodiments of the apparatus are merely illustrative, and the units described as separate parts may or may not be physically separate, and parts displayed as units may or may not be physical units, may be located in one place, or may be distributed on a plurality of network units. Some or all of the modules may be selected according to actual needs to achieve the purpose of the solution of the present embodiment. One of ordinary skill in the art can understand and implement it without inventive effort.

Through the above description of the embodiments, those skilled in the art will clearly understand that each embodiment can be implemented by software plus a necessary general hardware platform, and certainly can also be implemented by hardware. With this understanding in mind, the above-described technical solutions may be embodied in the form of a software product, which can be stored in a computer-readable storage medium such as ROM/RAM, magnetic disk, optical disk, etc., and includes instructions for causing a computer device (which may be a personal computer, a server, or a network device, etc.) to execute the methods described in the embodiments or some parts of the embodiments.

Finally, it should be noted that: the above examples are only intended to illustrate the technical solution of the present invention, but not to limit it; although the present invention has been described in detail with reference to the foregoing embodiments, it will be understood by those of ordinary skill in the art that: the technical solutions described in the foregoing embodiments may still be modified, or some technical features may be equivalently replaced; and such modifications or substitutions do not depart from the spirit and scope of the corresponding technical solutions of the embodiments of the present invention.

Claims

1. An organ perfusion transfer system, comprising:

a housing;

the refrigeration mechanism is arranged in the shell and is used for controlling the temperature of the first bin body;

2. The renal perfusion transport system of claim 1, wherein the refrigeration mechanism comprises:

3. The renal perfusion transport system of any one of claims 1, further comprising:

4. The renal perfusion transport system of claim 1, wherein the pump mechanism comprises:

5. The renal perfusion transport system of claim 1, further comprising:

6. The renal perfusion transport system of claim 1, further comprising:

7. The renal perfusion transport system of claim 1, further comprising:

8. The renal perfusion transport system of any one of claims 7, further comprising:

9. The renal perfusion transport system of claim 1, wherein the sensor assembly comprises:

10. The renal perfusion transport system of any one of claims 1, further comprising:

11. A method of controlling a renal perfusion transport system according to any one of claims 1 to 10, comprising: