CN114958709A - 可快速崩解的微载体聚集体及其制备方法 - Google Patents
可快速崩解的微载体聚集体及其制备方法 Download PDFInfo
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- CN114958709A CN114958709A CN202111487279.7A CN202111487279A CN114958709A CN 114958709 A CN114958709 A CN 114958709A CN 202111487279 A CN202111487279 A CN 202111487279A CN 114958709 A CN114958709 A CN 114958709A
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N5/00—Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
- C12N5/0068—General culture methods using substrates
- C12N5/0075—General culture methods using substrates using microcarriers
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- Biomedical Technology (AREA)
- Biotechnology (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Genetics & Genomics (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- General Engineering & Computer Science (AREA)
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Abstract
Description
Claims (10)
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Application Number | Priority Date | Filing Date | Title |
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CN202111487279.7A CN114958709B (zh) | 2021-12-07 | 2021-12-07 | 可快速崩解的微载体聚集体及其制备方法 |
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Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0155427A1 (fr) * | 1984-02-09 | 1985-09-25 | Societe D'applications Pharmaceutiques Et Biologiques Hoechst-Behring | Nouveau milieu de culture, solide, à délitement rapide, prêt à l'emploi et procédé pour le préparer |
JPS62190129A (ja) * | 1986-02-18 | 1987-08-20 | Green Cross Corp:The | 制癌剤含有マイクロキヤリアの製造方法 |
DD274336A3 (de) * | 1985-10-03 | 1989-12-20 | Npo Biolar | Verfahren zur Gewinnung einer Mikroträgersubstanz für die Zellkultivierung |
CN1297042A (zh) * | 1999-11-16 | 2001-05-30 | 韩国科学技术院 | 生物相容的支架的制备方法及由该方法制备的支架 |
CN1523055A (zh) * | 2003-09-09 | 2004-08-25 | �ൺ�Ƽ���ѧ�߷��ӿ�ѧ�빤��ѧԺ | 遇水崩解型环境友好高分子共混材料及其制取方法 |
CN101002961A (zh) * | 2006-12-31 | 2007-07-25 | 武汉工程大学 | 微孔双连续结构的多孔支架材料的制备方法 |
US20090186081A1 (en) * | 2006-01-05 | 2009-07-23 | Lifecycle Pharma A/S | Disintegrating Loadable Tablets |
CN102994441A (zh) * | 2012-09-19 | 2013-03-27 | 上海瀚康生物医药科技有限公司 | 一种细胞培养基及其制备方法和用途 |
WO2013041886A1 (en) * | 2011-09-21 | 2013-03-28 | Df&G Ltd | Effervescent cleaning composition comprising diamond powder having dv50 of less than 40micrometer |
CN104173290A (zh) * | 2014-07-31 | 2014-12-03 | 赵领 | 一种固体脂质纳米粒或脂质体及其制备方法 |
CN106620710A (zh) * | 2016-08-16 | 2017-05-10 | 张豪 | 一种微载体及其制备方法和用途 |
CN107750274A (zh) * | 2015-06-08 | 2018-03-02 | 康宁股份有限公司 | 用于水凝胶微载体的干燥制剂 |
CN109762802A (zh) * | 2019-01-28 | 2019-05-17 | 北京华龛生物科技有限公司 | 一种细胞载体颗粒聚集体及其制备方法 |
CN111559542A (zh) * | 2020-05-15 | 2020-08-21 | 北京华龛生物科技有限公司 | 一种使微载体聚集体保留吸水分散特性的辐照灭菌方法 |
CN113637635A (zh) * | 2021-10-13 | 2021-11-12 | 北京华龛生物科技有限公司 | 微载体细胞培养体系中微载体聚团状态的解散方法 |
-
2021
- 2021-12-07 CN CN202111487279.7A patent/CN114958709B/zh active Active
Patent Citations (15)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP0155427A1 (fr) * | 1984-02-09 | 1985-09-25 | Societe D'applications Pharmaceutiques Et Biologiques Hoechst-Behring | Nouveau milieu de culture, solide, à délitement rapide, prêt à l'emploi et procédé pour le préparer |
DD274336A3 (de) * | 1985-10-03 | 1989-12-20 | Npo Biolar | Verfahren zur Gewinnung einer Mikroträgersubstanz für die Zellkultivierung |
JPS62190129A (ja) * | 1986-02-18 | 1987-08-20 | Green Cross Corp:The | 制癌剤含有マイクロキヤリアの製造方法 |
CN1297042A (zh) * | 1999-11-16 | 2001-05-30 | 韩国科学技术院 | 生物相容的支架的制备方法及由该方法制备的支架 |
CN1523055A (zh) * | 2003-09-09 | 2004-08-25 | �ൺ�Ƽ���ѧ�߷��ӿ�ѧ�빤��ѧԺ | 遇水崩解型环境友好高分子共混材料及其制取方法 |
US20090186081A1 (en) * | 2006-01-05 | 2009-07-23 | Lifecycle Pharma A/S | Disintegrating Loadable Tablets |
CN101002961A (zh) * | 2006-12-31 | 2007-07-25 | 武汉工程大学 | 微孔双连续结构的多孔支架材料的制备方法 |
WO2013041886A1 (en) * | 2011-09-21 | 2013-03-28 | Df&G Ltd | Effervescent cleaning composition comprising diamond powder having dv50 of less than 40micrometer |
CN102994441A (zh) * | 2012-09-19 | 2013-03-27 | 上海瀚康生物医药科技有限公司 | 一种细胞培养基及其制备方法和用途 |
CN104173290A (zh) * | 2014-07-31 | 2014-12-03 | 赵领 | 一种固体脂质纳米粒或脂质体及其制备方法 |
CN107750274A (zh) * | 2015-06-08 | 2018-03-02 | 康宁股份有限公司 | 用于水凝胶微载体的干燥制剂 |
CN106620710A (zh) * | 2016-08-16 | 2017-05-10 | 张豪 | 一种微载体及其制备方法和用途 |
CN109762802A (zh) * | 2019-01-28 | 2019-05-17 | 北京华龛生物科技有限公司 | 一种细胞载体颗粒聚集体及其制备方法 |
CN111559542A (zh) * | 2020-05-15 | 2020-08-21 | 北京华龛生物科技有限公司 | 一种使微载体聚集体保留吸水分散特性的辐照灭菌方法 |
CN113637635A (zh) * | 2021-10-13 | 2021-11-12 | 北京华龛生物科技有限公司 | 微载体细胞培养体系中微载体聚团状态的解散方法 |
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