CN114949250A - 用于递送治疗剂的组合物、药物组合物、制备方法以及用途 - Google Patents

用于递送治疗剂的组合物、药物组合物、制备方法以及用途 Download PDF

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Publication number
CN114949250A
CN114949250A CN202210547670.XA CN202210547670A CN114949250A CN 114949250 A CN114949250 A CN 114949250A CN 202210547670 A CN202210547670 A CN 202210547670A CN 114949250 A CN114949250 A CN 114949250A
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China
Prior art keywords
psinp
porous silicon
sirna
composition
silicon
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Pending
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CN202210547670.XA
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Chinese (zh)
Inventor
迈克尔·J·赛勒
康珍英
朱珍明
埃米莉·安格林
埃斯特尔·科恩
马修·斯卡拉克
桑吉塔·巴蒂亚
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Spinnaker Biosciences Inc
Massachusetts Institute of Technology
University of California San Diego UCSD
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Spinnaker Biosciences Inc
Massachusetts Institute of Technology
University of California San Diego UCSD
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Publication of CN114949250A publication Critical patent/CN114949250A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/69—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit
    • A61K47/6921—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the conjugate being characterised by physical or galenical forms, e.g. emulsion, particle, inclusion complex, stent or kit the form being a particulate, a powder, an adsorbate, a bead or a sphere
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/16—Amides, e.g. hydroxamic acids
    • A61K31/165—Amides, e.g. hydroxamic acids having aromatic rings, e.g. colchicine, atenolol, progabide
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K31/33—Heterocyclic compounds
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    • A61K38/17—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • A61K49/0013—Luminescence
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    • A61K49/0069—Preparation for luminescence or biological staining characterised by a special physical or galenical form, e.g. emulsions, microspheres the agent being in a particular physical galenical form
    • A61K49/0089—Particulate, powder, adsorbate, bead, sphere
    • A61K49/0091—Microparticle, microcapsule, microbubble, microsphere, microbead, i.e. having a size or diameter higher or equal to 1 micrometer
    • A61K49/0093—Nanoparticle, nanocapsule, nanobubble, nanosphere, nanobead, i.e. having a size or diameter smaller than 1 micrometer, e.g. polymeric nanoparticle
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    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
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    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5107—Excipients; Inactive ingredients
    • A61K9/5115—Inorganic compounds
    • A—HUMAN NECESSITIES
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    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/48—Preparations in capsules, e.g. of gelatin, of chocolate
    • A61K9/50—Microcapsules having a gas, liquid or semi-solid filling; Solid microparticles or pellets surrounded by a distinct coating layer, e.g. coated microspheres, coated drug crystals
    • A61K9/51—Nanocapsules; Nanoparticles
    • A61K9/5192—Processes
    • C—CHEMISTRY; METALLURGY
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • B82Y5/00—Nanobiotechnology or nanomedicine, e.g. protein engineering or drug delivery
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    • C12N2310/00—Structure or type of the nucleic acid
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CN202210547670.XA 2016-04-14 2017-04-14 用于递送治疗剂的组合物、药物组合物、制备方法以及用途 Pending CN114949250A (zh)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201662322782P 2016-04-14 2016-04-14
US62/322,782 2016-04-14
CN201780037192.5A CN109843301B (zh) 2016-04-14 2017-04-14 用于递送治疗剂的含金属硅酸盐的多孔硅材料
PCT/US2017/027772 WO2017181115A1 (en) 2016-04-14 2017-04-14 Porous silicon materials comprising a metal silicate for delivery of therapeutic agents

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CN201780037192.5A Division CN109843301B (zh) 2016-04-14 2017-04-14 用于递送治疗剂的含金属硅酸盐的多孔硅材料

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CN201780037192.5A Active CN109843301B (zh) 2016-04-14 2017-04-14 用于递送治疗剂的含金属硅酸盐的多孔硅材料

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US (1) US20210177770A1 (https=)
EP (1) EP3442540A4 (https=)
JP (3) JP7093955B2 (https=)
CN (2) CN114949250A (https=)
AU (2) AU2017250300B2 (https=)
CA (1) CA3021001A1 (https=)
WO (1) WO2017181115A1 (https=)

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CN116510003B (zh) * 2023-06-20 2023-10-20 中国人民解放军军事科学院军事医学研究院 一种负载鼠疫菌rF1-V10蛋白的锰基纳米颗粒疫苗及其在抗鼠疫菌中的应用
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