CN114917292A - Intestinal microecological preparation for preventing and treating intestinal inflammatory diseases - Google Patents
Intestinal microecological preparation for preventing and treating intestinal inflammatory diseases Download PDFInfo
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- CN114917292A CN114917292A CN202210612439.4A CN202210612439A CN114917292A CN 114917292 A CN114917292 A CN 114917292A CN 202210612439 A CN202210612439 A CN 202210612439A CN 114917292 A CN114917292 A CN 114917292A
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- A61K36/484—Glycyrrhiza (licorice)
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- A61K36/71—Ranunculaceae (Buttercup family), e.g. larkspur, hepatica, hydrastis, columbine or goldenseal
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Abstract
The invention discloses an intestinal microecological preparation for preventing and treating intestinal inflammatory diseases, which comprises the following components in parts by weight: 90-100 parts of bifidobacterium, 90-100 parts of lactobacillus, 90-100 parts of streptococcus thermophilus, 14-16 parts of pinellia ternate, 8-10 parts of scutellaria baicalensis, 8-10 parts of honey-fried licorice root, 8-10 parts of ginseng, 2-4 parts of coptis chinensis, 5-8 parts of Chinese date and 6-7 parts of maple leaves. The intestinal tract micro-ecology is improved by using the intestinal tract cleaning agent to clean intestines and taking a micro-ecological preparation containing probiotics such as lactobacillus, bifidobacterium and the like with high survival rate after intestinal tract operation, and finally the purpose of preventing and treating intestinal tract inflammation is realized.
Description
Technical Field
The invention relates to the technical field of biological preparations, in particular to an intestinal microecological preparation for preventing and treating intestinal inflammatory diseases.
Background
A microbial preparation is a living microbial preparation prepared from normal microorganisms or substances for promoting the growth of microorganisms. That is, all preparations which promote the growth and reproduction of normal microbiota and inhibit the growth and reproduction of pathogenic bacteria are called "probiotics". Due to the efficacy of regulating the intestinal tract, the intestinal micro-ecological balance is quickly constructed, and the diarrhea and constipation can be prevented and treated no matter in infants, old people or newborn livestock and poultry.
In the traditional strategy for repairing the intestinal microecological system, the used microecological preparation cannot ensure the survival rate of probiotics in the intestinal microecological system when the probiotics pass through the gastrointestinal tract, and the recovery and the improvement of the intestinal microecology of the probiotics such as bifidobacterium, lactobacillus and the like after the intestinal tract preparation after the intestinal tract operation are greatly limited. Meanwhile, the contained prebiotics are mostly soluble fructo-oligosaccharides, galacto-oligosaccharides, inulin and the like, the nutritional ingredients are single, the diversity of the nutrient substance basis of the intestinal flora cannot be guaranteed, and the repairing effect is not ideal.
Disclosure of Invention
In order to solve the above-mentioned drawbacks of the background art, it is an object of the present invention to provide an intestinal micro-ecological preparation for preventing and treating inflammatory diseases of the intestinal tract, which can restore/reconstruct/construct the intestinal micro-ecology of a human body after the intestinal tract is cleaned. The intestinal tract is cleared by the intestinal clearing agent (namely intestinal tract preparation), and after intestinal tract operation, a microecological preparation containing high-survival-rate microorganisms such as lactobacillus, bifidobacterium and other probiotics is taken to improve (reconstruct or restore) the intestinal tract microecology, so that the aim of preventing and treating intestinal inflammation is finally fulfilled.
The purpose of the invention can be realized by the following technical scheme:
an intestinal microecological preparation for the prevention and treatment of inflammatory diseases of the intestinal tract, comprising the following components by weight:
90-100 parts of bifidobacterium;
90-100 parts of lactobacillus;
90-100 parts of streptococcus thermophilus;
14-16 parts of pinellia ternata;
8-10 parts of scutellaria;
8-10 parts of honey-fried licorice root;
8-10 parts of ginseng;
2-4 parts of coptis chinensis;
5-8 parts of Chinese dates;
6-7 parts of maple leaves.
In a preferred embodiment of the present invention, the bifidobacterium is one or more of bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis and bifidobacterium longum.
In a preferred embodiment of the present invention, the lactobacillus is one or more of lactobacillus acidophilus powder, lactobacillus casei, lactobacillus bulgaricus, lactobacillus delbrueckii, lactobacillus subspecies lactis, lactobacillus fermentum, lactobacillus helveticus, lactobacillus salivarius, lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, and lactobacillus johnsonii.
As a preferred embodiment of the present invention, the following components are included by weight:
90-95 parts of bifidobacterium;
90-95 parts of lactobacillus;
90-95 parts of streptococcus thermophilus;
14-15 parts of pinellia ternata;
8-9 parts of scutellaria baicalensis;
8-9 parts of honey-fried licorice root;
8-9 parts of ginseng;
2-3 parts of coptis chinensis;
5-7 parts of Chinese dates;
6-6.5 parts of maple leaves.
As a preferred embodiment of the present invention, the following components are included by weight:
92-95 parts of bifidobacterium;
92-95 parts of lactobacillus;
92-95 parts of streptococcus thermophilus;
14.5-15 parts of pinellia ternata;
8.5-9 parts of scutellaria baicalensis;
8.5-9 parts of honey-fried licorice root;
8.5-9 parts of ginseng;
2.5-3 parts of coptis chinensis;
6-7 parts of Chinese dates;
6.2-6.5 parts of maple leaves.
A preparation method of an intestinal microecological preparation for preventing and treating intestinal inflammatory diseases comprises the following steps:
s1, cleaning rhizoma Pinelliae, radix Scutellariae, radix Glycyrrhizae Preparata, radix Ginseng, rhizoma Coptidis, fructus Jujubae, and maple leaf, oven drying, and grinding rhizoma Pinelliae, radix Scutellariae, radix Glycyrrhizae Preparata, radix Ginseng, rhizoma Coptidis, fructus Jujubae, and maple leaf into mixed powder;
s2, mixing the mixed powder with the bifidobacteria, the lactobacilli, the streptococcus thermophilus and the polysaccharide solution, then adding the culture solution, and culturing at 30-40 ℃ for 10-24h to obtain a bacterium-containing mixed solution;
s3, adding the mixed solution containing bacteria into calcium chloride solution, standing and filtering to obtain a precipitate primary microecological preparation
And S4, adding the primary microecological preparation into the chitosan solution, and embedding to obtain the microecological preparation.
As a preferable scheme of the invention, the polysaccharide solution is obtained by mixing sodium alginate, konjac mannan, xylan, L-arabinose and water.
The beneficial effects of the invention are as follows:
1. the invention can restore/rebuild/construct the human intestinal micro-ecology after the intestinal cleaning. The intestinal tract micro-ecology is improved (reconstructed or restored) by taking a micro-ecological preparation containing probiotics such as lactobacillus, bifidobacterium and the like with high survival rate after intestinal tract operation through the intestine clearing agent (namely intestinal tract preparation), and finally the purpose of preventing and treating intestinal inflammation is realized;
2. the invention specifically rebuilds the micro-ecology of the intestinal tract of a human body in a multi-aspect mode by utilizing the characteristics of the traditional Chinese medicine through adding the pinellia ternate, the scutellaria baicalensis, the honey-fried licorice root, the ginseng, the coptis chinensis, the Chinese date and the maple leaves, achieves the effects of stabilizing the health state and reducing the development of related diseases causing heart diseases, and is safe, effective and small in toxic and side effects.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
An intestinal microecological preparation for the prevention and treatment of inflammatory diseases of the intestinal tract, which comprises the following components by weight:
90-100 parts of bifidobacterium;
90-100 parts of lactobacillus;
90-100 parts of streptococcus thermophilus;
14-16 parts of pinellia ternata;
8-10 parts of scutellaria baicalensis;
8-10 parts of honey-fried licorice root;
8-10 parts of ginseng;
2-4 parts of coptis chinensis;
5-8 parts of Chinese dates;
6-7 parts of maple leaves.
In a preferred embodiment of the present invention, the bifidobacterium is one or more of bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis and bifidobacterium longum.
In a preferred embodiment of the present invention, the lactobacillus is one or more of lactobacillus acidophilus powder, lactobacillus casei, lactobacillus bulgaricus, lactobacillus delbrueckii, lactobacillus subspecies lactis, lactobacillus fermentum, lactobacillus helveticus, lactobacillus salivarius, lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, and lactobacillus johnsonii.
Example 1
A preparation method of an intestinal microecological preparation for preventing and treating intestinal inflammatory diseases comprises the following steps:
s1, cleaning rhizoma Pinelliae, radix Scutellariae, radix Glycyrrhizae Preparata, radix Ginseng, rhizoma Coptidis, fructus Jujubae, and maple leaf, oven drying, and grinding rhizoma Pinelliae, radix Scutellariae, radix Glycyrrhizae Preparata, radix Ginseng, rhizoma Coptidis, fructus Jujubae, and maple leaf into mixed powder;
s2, mixing the mixed powder with bifidobacteria, lactobacillus, streptococcus thermophilus and polysaccharide solution, adding culture solution, and culturing at 30 deg.C for 10 hr to obtain mixed solution containing bacteria;
s3, adding the mixed solution containing bacteria into calcium chloride solution, standing and filtering to obtain a precipitate primary microecological preparation
And S4, adding the primary microecological preparation into a chitosan solution, and embedding to obtain the microecological preparation.
As a preferable scheme of the invention, the polysaccharide solution is obtained by mixing sodium alginate, konjac mannan, xylan, L-arabinose and water.
Example 2
A preparation method of an intestinal microecological preparation for preventing and treating intestinal inflammatory diseases comprises the following steps:
s1, cleaning rhizoma Pinelliae, radix Scutellariae, radix Glycyrrhizae Preparata, radix Ginseng, rhizoma Coptidis, fructus Jujubae, and maple leaf, oven drying, and grinding rhizoma Pinelliae, radix Scutellariae, radix Glycyrrhizae Preparata, radix Ginseng, rhizoma Coptidis, fructus Jujubae, and maple leaf into mixed powder;
s2, mixing the mixed powder with bifidobacteria, lactobacillus, streptococcus thermophilus and polysaccharide solution, adding culture solution, and culturing at 40 deg.C for 24 hr to obtain mixed solution containing bacteria;
s3, adding the mixed solution containing bacteria into calcium chloride solution, standing and filtering to obtain a precipitate primary microecological preparation
And S4, adding the primary microecological preparation into the chitosan solution, and embedding to obtain the microecological preparation.
As a preferable scheme of the invention, the polysaccharide solution is obtained by mixing sodium alginate, konjac mannan, xylan, L-arabinose and water.
In the description herein, references to the description of "one embodiment," "an example," "a specific example" or the like are intended to mean that a particular feature, structure, material, or characteristic described in connection with the embodiment or example is included in at least one embodiment or example of the invention. In this specification, the schematic representations of the terms used above do not necessarily refer to the same embodiment or example. Furthermore, the particular features, structures, materials, or characteristics described may be combined in any suitable manner in any one or more embodiments or examples.
The foregoing shows and describes the general principles, essential features, and advantages of the invention. It will be understood by those skilled in the art that the present invention is not limited to the embodiments described above, which are described in the specification and illustrated only to illustrate the principle of the present invention, but that various changes and modifications may be made therein without departing from the spirit and scope of the present invention, which fall within the scope of the invention as claimed.
The above description is only for the purpose of illustrating the preferred embodiments of the present invention and should not be taken as limiting the invention, and any modifications, equivalents and simple improvements made on the spirit of the present invention should be included in the scope of the present invention.
Claims (7)
1. An intestinal microecological formulation for the prevention and treatment of inflammatory diseases of the intestinal tract, comprising by weight:
90-100 parts of bifidobacterium;
90-100 parts of lactobacillus;
90-100 parts of streptococcus thermophilus;
14-16 parts of pinellia ternata;
8-10 parts of scutellaria baicalensis;
8-10 parts of honey-fried licorice root;
8-10 parts of ginseng;
2-4 parts of coptis chinensis;
5-8 parts of Chinese dates;
6-7 parts of maple leaves.
2. The gut probiotic formulation according to claim 1, wherein the bifidobacteria is one or more of bifidobacterium adolescentis, bifidobacterium lactis, bifidobacterium bifidum, bifidobacterium breve, bifidobacterium infantis and bifidobacterium longum.
3. The enteric microecological formulation according to claim 1, wherein the lactobacillus is one or more of lactobacillus acidophilus powder, lactobacillus casei, lactobacillus bulgaricus, lactobacillus delbrueckii, lactobacillus subspecies lactis, lactobacillus fermentum, lactobacillus helveticus, lactobacillus salivarius, lactobacillus rhamnosus, lactobacillus reuteri, lactobacillus plantarum, lactobacillus paracasei, and lactobacillus johnsonii.
4. The enteric microecological formulation for the prevention and treatment of intestinal inflammatory diseases according to claim 1, comprising the following components by weight:
90-95 parts of bifidobacterium;
90-95 parts of lactobacillus;
90-95 parts of streptococcus thermophilus;
14-15 parts of pinellia ternata;
8-9 parts of scutellaria baicalensis;
8-9 parts of honey-fried licorice root;
8-9 parts of ginseng;
2-3 parts of coptis chinensis;
5-7 parts of Chinese dates;
6-6.5 parts of maple leaves.
5. The enteric microecological formulation for the prevention and treatment of intestinal inflammatory diseases according to claim 1, comprising the following components by weight:
92-95 parts of bifidobacterium;
92-95 parts of lactobacillus;
92-95 parts of streptococcus thermophilus;
14.5-15 parts of pinellia ternata;
8.5-9 parts of scutellaria baicalensis;
8.5-9 parts of honey-fried licorice root;
8.5-9 parts of ginseng;
2.5-3 parts of coptis chinensis;
6-7 parts of Chinese dates;
6.2-6.5 parts of maple leaves.
6. A preparation method of an intestinal microecological preparation for preventing and treating intestinal inflammatory diseases is characterized by comprising the following steps of:
s1, cleaning rhizoma Pinelliae, radix Scutellariae, radix Glycyrrhizae Preparata, radix Ginseng, rhizoma Coptidis, fructus Jujubae, and maple leaf, oven drying, and grinding rhizoma Pinelliae, radix Scutellariae, radix Glycyrrhizae Preparata, radix Ginseng, rhizoma Coptidis, fructus Jujubae, and maple leaf into mixed powder;
s2, mixing the mixed powder with the bifidobacteria, the lactobacilli, the streptococcus thermophilus and the polysaccharide solution, then adding the culture solution, and culturing at 30-40 ℃ for 10-24h to obtain a bacterium-containing mixed solution;
s3, adding the mixed solution containing bacteria into calcium chloride solution, standing and filtering to obtain a precipitate primary microecological preparation
And S4, adding the primary microecological preparation into a chitosan solution, and embedding to obtain the microecological preparation.
7. The enteric microecological formulation according to claim 1, wherein the polysaccharide solution is a mixture of sodium alginate, konjac mannan, xylan, and L-arabinose with water.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404756A (en) * | 2013-05-27 | 2013-11-27 | 胡安然 | Special diet for gastroenteritis patients |
| CN104222732A (en) * | 2014-04-04 | 2014-12-24 | 胡安然 | Intestinal micro-ecological preparation for preventing and treating intestinal inflammatory diseases |
| CN111166858A (en) * | 2019-12-05 | 2020-05-19 | 沈阳药科大学 | Preparation method of stomach harmonizing granules |
| CN112370470A (en) * | 2020-11-18 | 2021-02-19 | 复旦大学附属中山医院 | Microecological preparation for reconstructing intestinal microecology |
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- 2022-05-31 CN CN202210612439.4A patent/CN114917292A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404756A (en) * | 2013-05-27 | 2013-11-27 | 胡安然 | Special diet for gastroenteritis patients |
| CN104222732A (en) * | 2014-04-04 | 2014-12-24 | 胡安然 | Intestinal micro-ecological preparation for preventing and treating intestinal inflammatory diseases |
| CN111166858A (en) * | 2019-12-05 | 2020-05-19 | 沈阳药科大学 | Preparation method of stomach harmonizing granules |
| CN112370470A (en) * | 2020-11-18 | 2021-02-19 | 复旦大学附属中山医院 | Microecological preparation for reconstructing intestinal microecology |
Non-Patent Citations (1)
| Title |
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| 赵建一: "半夏泻心汤现代药理研究浅述" * |
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