CN114917143A - 一种抗皮肤衰老的海参多肽修复精华液及其制备方法 - Google Patents
一种抗皮肤衰老的海参多肽修复精华液及其制备方法 Download PDFInfo
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Abstract
本发明属于护肤品领域，公开了一种抗皮肤衰老的海参多肽修复精华液及其制备方法。本发明以海参加工废弃物海参内脏为原料，研发出抗皮肤衰老的海参多肽修复精华液，原料组成包括海参多肽提取物0.8‑1.2％、透明质酸钠0.03‑0.05％、EDTA二钠0.02‑0.04％、黄原胶0.02‑0.04％、海藻糖0.8‑1.2％、甘油4‑6％、丁二醇5‑7％、卡波姆0.1‑0.3％、对羟基苯乙酮0.3‑0.7％、生育酚乙酸酯0.3‑0.7％、精氨酸0.1‑0.3％、乙基己基甘油0.3‑0.7％、余量为去离子水。在本发明中，所述海参多肽修复精华液，能够增加皮肤含水量，修复皮肤，抗氧化能力强，抗衰老效果好，是一种基于海洋废弃物再利用的新型护肤品。
Description
技术领域
本发明属于护肤品领域，具体涉及一种抗皮肤衰老的海参多肽修复精华液及其制备方法。
背景技术
海参是一种在地球上存在历史悠久且珍贵的海产动物。海参味道鲜美，含蛋白质，脂肪、人体所需的微量元素以及维生素等50多种对人体生理活动有益的营养成分，具有很高的营养价值和药用价值。目前，人们对海参产品的加工往往都会将海参内脏去除，但是经过研究发现，海参内脏同样含有大量的海参蛋白等海参主体所含有的营养成分。目前对海参内脏活性物质认识的缺乏和忽视，已造成资源严重浪费和流失。对海参内脏的高值化综合利用成为本领域亟待解决的技术难题。
皮肤作为人体最大的器官，是人体防御外界伤害和防止体液流失的重要屏障。但是，随着年龄的增长以及外界环境的污染和日光的照射，会导致皮肤干燥缺水，松弛下垂，缺乏弹性。因此，如何在一定程度上缓解这个过程，是人们重点关注的问题。在这种发展趋势下，抗皮肤衰老的产品具有广阔的市场。目前市场上现有的抗衰老产品质量参差不齐，功效单一、效果不理想。
发明内容
为了克服以上现有技术的不足，本发明以海参产品加工后的副产物海参肠为原料，研发出抗皮肤衰老的海参多肽修复精华液，旨在提供一种能够增加皮肤含水量，修复皮肤，抗氧化能力强，抗衰老效果好的海参多肽修复精华液，是一种基于海洋废弃物再利用的新型护肤品。
为达到上述目的，本发明主要是通过以下技术方案实现：
一种抗皮肤衰老的海参多肽修复精华液，按原料配伍质量百分比包括：海参多肽提取物0.8-1.2％、透明质酸钠0.03-0.05％、EDTA二钠0.02-0.04％、黄原胶0.02-0.04％、海藻糖0.8-1.2％、甘油4-6％、丁二醇5-7％、卡波姆0.1-0.3％、对羟基苯乙酮0.3-0.7％、生育酚乙酸酯0.3-0.7％、精氨酸0.1-0.3％、乙基己基甘油0.3-0.7％、余量为去离子水。其中海参多肽提取物作为功能成分，透明质酸钠、甘油、丁二醇作为保湿剂，EDTA二钠作为螯合剂，黄原胶作为增稠剂，海藻糖作为皮肤调理剂、柔润剂、保湿剂，卡波姆作为增稠剂、乳化稳定剂，对羟基苯乙酮、生育酚乙酸酯作为抗氧化的成分，精氨酸作为pH调节剂、保湿剂，乙基己基甘油作为保湿剂、防腐剂、肤感调节剂，去离子水为溶剂。
进一步地，上述抗皮肤衰老的海参多肽修复精华液，按原料配伍质量百分比包括：海参多肽提取物1.0％、透明质酸钠0.04％、EDTA二钠0.03％、黄原胶0.03％、海藻糖1.0％、甘油5％、丁二醇6％、卡波姆0.2％、对羟基苯乙酮0.5％、生育酚乙酸酯0.5％、精氨酸0.2％、乙基己基甘油0.5％、余量为去离子水。
本发明提供一种抗皮肤衰老的海参多肽修复精华液的制备方法，用于制备上述海参多肽修复精华液，制备方法包括如下步骤：
(1)将卡波姆表面洒于去离子水润湿，将透明质酸钠和黄原胶分散与丁二醇中，再加入EDTA二钠、海藻糖、甘油、对羟基苯乙酮、生育酚乙酸酯，混合均匀加热至85℃。
(2)降温至60℃，将精氨酸加入上述步骤(1)的物料中和。
(3)降温至40℃，将海参肽提取物和乙基己基甘油加入到上述步骤(2)的物料中，充分搅拌均匀，降温至常温，即得海参多肽修复精华液。
进一步地，所述海参多肽提取物是由海参加工废弃物海参内脏为原料提取。
进一步地，所述海参多肽提取物以海参产品加工后的副产物海参肠为原料，采用安全、高效的蛋白酶酶解法得到海参肽提取物。
进一步地，所述海参多肽提取物的制备方法为：按料液比1:5加入去离子水，将海参肠和水混合均匀，选用酶活性为100u/g的碱性蛋白酶在pH为8的条件下加入处理干净的海参肠中，加酶量质量比为0.5％，在50℃水浴锅中酶解3h，将酶解液在6000r/min的条件下离心5min，取上清液进行保存，即得海参肽提取物。
本发明与现有技术相比的有益效果在于：
(1)本发明对海参加工废弃物海参内脏进行加工利用，不仅充分利用被忽视的海洋废弃物资源，达到变废为宝的目的，将资源的利用达到最大化，而且开发以天然成分为主的精华液，为消费者提供更多选择，具有十分重要的意义。
(2)本发明以海参加工废弃物海参内脏为原料提取出海参多肽提取物，配合适当的辅料，开发一种安全温和、无刺激、无毒副作用的修复精华液。本发明提供的具有协同增效作用的配方组合，能够增加皮肤含水量，修复皮肤，抗氧化能力强，抗衰老效果好，并且生产工艺简单，适合规模化生产。
具体实施方式
下面通过具体实施例详述本发明，但不限制本发明的保护范围。如无特殊说明，本发明所采用的实验方法均为常规方法，所用实验器材、材料、试剂等均可从商业途径获得。
实施例1
将0.2％卡波姆洒于水面润湿，将0.04％透明质酸钠和0.03％黄原胶分散与6％丁二醇中，再加入0.03％EDTA二钠、1.0％海藻糖、5％甘油、0.5％对羟基苯乙酮、0.5％生育酚乙酸酯，混合均匀加热至85℃。
降温至60℃，将0.2％精氨酸加入上述物料中和。
降温至40℃，将1.0％海参肽提取物和0.5％乙基己基甘油加入到上述物料中，充分搅拌均匀，降温至常温，即得海参多肽修复精华液。
使用方法：取适量精华液，均匀涂抹在面部，轻轻拍打或者以按压的手法，促进精华液的吸收。
实施例2
将0.1％卡波姆洒于水面润湿，将0.03％透明质酸钠和0.02％黄原胶分散与5％丁二醇中，再加入0.02％EDTA二钠、0.8％海藻糖、4％甘油、0.3％对羟基苯乙酮、0.3％生育酚乙酸酯，混合均匀加热至85℃。
降温至60℃，将0.1％精氨酸加入上述物料中和。
降温至40℃，将0.8％海参肽提取物和0.3％乙基己基甘油加入到上述物料中，充分搅拌均匀，降温至常温，即得海参多肽修复精华液。
使用方法：取适量精华液，均匀涂抹在面部，轻轻拍打或者以按压的手法，促进精华液的吸收。
实施例3
将0.3％卡波姆洒于水面润湿，将0.05％透明质酸钠和0.04％黄原胶分散与7％丁二醇中，再加入0.04％EDTA二钠、1.2％海藻糖、6％甘油、0.7％对羟基苯乙酮、0.7％生育酚乙酸酯，混合均匀加热至85℃。
降温至60℃，将0.3％精氨酸加入上述物料中和。
降温至40℃，将1.2％海参肽提取物和0.7％乙基己基甘油加入到上述物料中，充分搅拌均匀，降温至常温，即得海参多肽修复精华液。
使用方法：取适量精华液，均匀涂抹在面部，轻轻拍打或者以按压的手法，促进精华液的吸收。
实施例4
实施例1-3所述海参多肽提取物的制备方法为：按料液比1:5加入去离子水，将海参肠和水混合均匀，选用酶活性为100u/g的碱性蛋白酶在pH为8的条件下加入处理干净的海参肠中，加酶量质量比为0.5％，在50℃水浴锅中酶解3h，将酶解液在6000r/min的条件下离心5min，取上清液进行保存，即得海参肽提取物。
对比例1
市售某品牌精华液
对实施例1和对比例1进行3h保湿效果测试，参照QB/T 4256-2011化妆品保湿功效评价指南，每个样品选取5名测试者，取上述实施例1和对比例1中的样品定量涂抹于手臂固定部位。测量使用样品前即未使用样品的初始值、使用后0h即使用样品的初始值，于涂抹擦拭后拍打10s后测试，1h、3h皮肤角质层水油含量以及经皮水分流失率数值，记录所得数值并计算平均值，结果参见表1。
表1皮肤角质层水油含量
对表1中数据进行进一步分析，结果如下：
对实施例1和对比例1各组数据进行分析，结果用平均值±标准差表示。试验结果表明，实施例1的使用样品后0h比未使用样品时的水分含量从33.4±3.0％提升至68.8±4.7％，水分含量约提升至2.1倍，对比例1从32.6±3.0％提升至61.2±3.7％，水分含量提升至1.9倍，该结果表明实施例1比对比例1在使用初期水分含量提升更著。
实施例1含油率从53.0±0.7％降至38.2±2.2％，降幅为27.9％，对比例1从51.8±1.6％降至42.0±2.7％，降幅为18.9％，该结果表明实施例1比在使用初期含油量降低幅度大于对比例1。
在试验1h和3h时分别检测皮肤水油含量，结果表明，试验1h后，实施例1水分含量和含油量分别为46.0±2.7％和47±0.7％，基本达到水油平衡。试验3h后，水分含量和含油量分别为44±4.4％和47.8±1.6％，与使用前的水油比例相对比，实施例1在3h后也基本达到水油平衡，该结果表明实施例1产品在使用3h后仍能够保证皮肤的水油平衡，保湿效果显著。而对比例1在试验1h后水油含量分别为36.4±2.1％和49.8±1.3％，3h后水油含量分别为34.4±2.9％和51.2±1.9％，恢复到使用前水油比例，结果表明对比例1在使用1h后无明显保湿效果。
以上所述，仅为本发明较佳的具体实施方式，但本发明的保护范围并不局限于此，任何熟悉本技术领域的技术人员在本发明揭露的技术范围内，可轻易想到的变化或替换，都应涵盖在本发明的保护范围之内。
Claims (6)
1.一种抗皮肤衰老的海参多肽修复精华液，其特征在于，按原料配伍质量百分比包括：海参多肽提取物0.8-1.2％、透明质酸钠0.03-0.05％、EDTA二钠0.02-0.04％、黄原胶0.02-0.04％、海藻糖0.8-1.2％、甘油4-6％、丁二醇5-7％、卡波姆0.1-0.3％、对羟基苯乙酮0.3-0.7％、生育酚乙酸酯0.3-0.7％、精氨酸0.1-0.3％、乙基己基甘油0.3-0.7％、余量为去离子水。
2.如权利要求1所述的一种抗皮肤衰老的海参多肽修复精华液，其特征在于，按原料配伍质量百分比包括：海参多肽提取物1.0％、透明质酸钠0.04％、EDTA二钠0.03％、黄原胶0.03％、海藻糖1.0％、甘油5％、丁二醇6％、卡波姆0.2％、对羟基苯乙酮0.5％、生育酚乙酸酯0.5％、精氨酸0.2％、乙基己基甘油0.5％、余量为去离子水。
3.一种抗皮肤衰老的海参多肽修复精华液的制备方法，其特征在于，包括如下步骤：
(1)将卡波姆表面洒于去离子水润湿，将透明质酸钠和黄原胶分散与丁二醇中，再加入EDTA二钠、海藻糖、甘油、对羟基苯乙酮、生育酚乙酸酯，混合均匀加热至85℃；
(2)降温至60℃，将精氨酸加入上述步骤(1)的物料中和；
(3)降温至40℃，将海参肽提取物和乙基己基甘油加入到上述步骤(2)的物料中，充分搅拌均匀，降温至常温，即得海参多肽修复精华液。
4.如权利要求3所述的一种抗皮肤衰老的海参多肽修复精华液的制备方法，其特征在于，所述海参多肽提取物是由海参加工废弃物海参内脏为原料提取。
5.如权利要求3所述的一种抗皮肤衰老的海参多肽修复精华液的制备方法，其特征在于，所述海参多肽提取物以海参产品加工后的副产物海参肠为原料，采用蛋白酶酶解法得到。
6.如权利要求3所述的一种抗皮肤衰老的海参多肽修复精华液的制备方法，其特征在于，所述海参多肽提取物的制备方法为：按料液比1:5加入去离子水，将海参肠和水混合均匀，选用酶活性为100u/g的碱性蛋白酶在pH为8的条件下加入处理干净的海参肠中，加酶量质量比为0.5％，在50℃水浴锅中酶解3h，将酶解液在6000r/min的条件下离心5min，取上清液进行保存，即得海参肽提取物。
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Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265419A (zh) * | 2016-08-17 | 2017-01-04 | 倪娟形 | 美白保湿面膜液及其制备方法 |
| CN108096066A (zh) * | 2017-12-29 | 2018-06-01 | 广州慈康生物科技有限公司 | 一种保湿精华液 |
| CN108324587A (zh) * | 2018-04-17 | 2018-07-27 | 佛山汇沐化学科技有限公司 | 一种抗老除皱组合物 |
| CN109984977A (zh) * | 2019-05-21 | 2019-07-09 | 上海乾一化学品有限公司 | 一种含植物糖原的精华液及其制备方法 |
| CN110538131A (zh) * | 2019-10-12 | 2019-12-06 | 烟台华康海洋食品有限公司 | 一种海参面膜及其加工方法 |
| CN113693955A (zh) * | 2020-10-09 | 2021-11-26 | 广州俏姿颜化妆品有限公司 | 一种精华液 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN106265419A (zh) * | 2016-08-17 | 2017-01-04 | 倪娟形 | 美白保湿面膜液及其制备方法 |
| CN108096066A (zh) * | 2017-12-29 | 2018-06-01 | 广州慈康生物科技有限公司 | 一种保湿精华液 |
| CN108324587A (zh) * | 2018-04-17 | 2018-07-27 | 佛山汇沐化学科技有限公司 | 一种抗老除皱组合物 |
| CN109984977A (zh) * | 2019-05-21 | 2019-07-09 | 上海乾一化学品有限公司 | 一种含植物糖原的精华液及其制备方法 |
| CN110538131A (zh) * | 2019-10-12 | 2019-12-06 | 烟台华康海洋食品有限公司 | 一种海参面膜及其加工方法 |
| CN113693955A (zh) * | 2020-10-09 | 2021-11-26 | 广州俏姿颜化妆品有限公司 | 一种精华液 |
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