CN114916552A - Compound agricultural bactericide containing penthiopyrad and application thereof - Google Patents
Compound agricultural bactericide containing penthiopyrad and application thereof Download PDFInfo
- Publication number
- CN114916552A CN114916552A CN202210528018.3A CN202210528018A CN114916552A CN 114916552 A CN114916552 A CN 114916552A CN 202210528018 A CN202210528018 A CN 202210528018A CN 114916552 A CN114916552 A CN 114916552A
- Authority
- CN
- China
- Prior art keywords
- penthiopyrad
- active component
- bupirimate
- compound agricultural
- pyraclostrobin
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- QYDYPVFESGNLHU-UHFFFAOYSA-N elaidic acid methyl ester Natural products CCCCCCCCC=CCCCCCCCC(=O)OC QYDYPVFESGNLHU-UHFFFAOYSA-N 0.000 description 1
- 239000004495 emulsifiable concentrate Substances 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
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- BEFDCLMNVWHSGT-UHFFFAOYSA-N ethenylcyclopentane Chemical compound C=CC1CCCC1 BEFDCLMNVWHSGT-UHFFFAOYSA-N 0.000 description 1
- 239000000194 fatty acid Substances 0.000 description 1
- 229930195729 fatty acid Natural products 0.000 description 1
- 244000037666 field crops Species 0.000 description 1
- 229910021485 fumed silica Inorganic materials 0.000 description 1
- 238000010413 gardening Methods 0.000 description 1
- 230000035784 germination Effects 0.000 description 1
- 229940095098 glycol oleate Drugs 0.000 description 1
- WGCNASOHLSPBMP-UHFFFAOYSA-N hydroxyacetaldehyde Natural products OCC=O WGCNASOHLSPBMP-UHFFFAOYSA-N 0.000 description 1
- 239000001863 hydroxypropyl cellulose Substances 0.000 description 1
- 235000010977 hydroxypropyl cellulose Nutrition 0.000 description 1
- 208000006278 hypochromic anemia Diseases 0.000 description 1
- 239000003112 inhibitor Substances 0.000 description 1
- 238000011081 inoculation Methods 0.000 description 1
- 229910017053 inorganic salt Inorganic materials 0.000 description 1
- 230000002262 irrigation Effects 0.000 description 1
- 238000003973 irrigation Methods 0.000 description 1
- 229920005610 lignin Polymers 0.000 description 1
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- 229920000609 methyl cellulose Polymers 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- QYDYPVFESGNLHU-KHPPLWFESA-N methyl oleate Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OC QYDYPVFESGNLHU-KHPPLWFESA-N 0.000 description 1
- 229940073769 methyl oleate Drugs 0.000 description 1
- 239000001923 methylcellulose Substances 0.000 description 1
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- 239000002480 mineral oil Substances 0.000 description 1
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- 239000010705 motor oil Substances 0.000 description 1
- 150000004002 naphthaldehydes Chemical class 0.000 description 1
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- 229910052625 palygorskite Inorganic materials 0.000 description 1
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- 230000002093 peripheral effect Effects 0.000 description 1
- 239000000546 pharmaceutical excipient Substances 0.000 description 1
- 229960005323 phenoxyethanol Drugs 0.000 description 1
- ONJQDTZCDSESIW-UHFFFAOYSA-N polidocanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO ONJQDTZCDSESIW-UHFFFAOYSA-N 0.000 description 1
- 229920001495 poly(sodium acrylate) polymer Polymers 0.000 description 1
- 239000004584 polyacrylic acid Substances 0.000 description 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 1
- 229920001451 polypropylene glycol Polymers 0.000 description 1
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- 239000000843 powder Substances 0.000 description 1
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- POCCEQRNLCTSPC-UHFFFAOYSA-N propan-2-yl 2-dodecylbenzenesulfonate Chemical compound CCCCCCCCCCCCC1=CC=CC=C1S(=O)(=O)OC(C)C POCCEQRNLCTSPC-UHFFFAOYSA-N 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
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- 230000000630 rising effect Effects 0.000 description 1
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- 229910052624 sepiolite Inorganic materials 0.000 description 1
- 235000019355 sepiolite Nutrition 0.000 description 1
- RMAQACBXLXPBSY-UHFFFAOYSA-N silicic acid Chemical compound O[Si](O)(O)O RMAQACBXLXPBSY-UHFFFAOYSA-N 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 235000012239 silicon dioxide Nutrition 0.000 description 1
- 229940047670 sodium acrylate Drugs 0.000 description 1
- WXMKPNITSTVMEF-UHFFFAOYSA-M sodium benzoate Chemical compound [Na+].[O-]C(=O)C1=CC=CC=C1 WXMKPNITSTVMEF-UHFFFAOYSA-M 0.000 description 1
- 239000004299 sodium benzoate Substances 0.000 description 1
- 235000010234 sodium benzoate Nutrition 0.000 description 1
- 229960003885 sodium benzoate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- 229940080264 sodium dodecylbenzenesulfonate Drugs 0.000 description 1
- NNMHYFLPFNGQFZ-UHFFFAOYSA-M sodium polyacrylate Chemical compound [Na+].[O-]C(=O)C=C NNMHYFLPFNGQFZ-UHFFFAOYSA-M 0.000 description 1
- 229960004025 sodium salicylate Drugs 0.000 description 1
- PYODKQIVQIVELM-UHFFFAOYSA-M sodium;2,3-bis(2-methylpropyl)naphthalene-1-sulfonate Chemical compound [Na+].C1=CC=C2C(S([O-])(=O)=O)=C(CC(C)C)C(CC(C)C)=CC2=C1 PYODKQIVQIVELM-UHFFFAOYSA-M 0.000 description 1
- NHQVTOYJPBRYNG-UHFFFAOYSA-M sodium;2,4,7-tri(propan-2-yl)naphthalene-1-sulfonate Chemical compound [Na+].CC(C)C1=CC(C(C)C)=C(S([O-])(=O)=O)C2=CC(C(C)C)=CC=C21 NHQVTOYJPBRYNG-UHFFFAOYSA-M 0.000 description 1
- MZSDGDXXBZSFTG-UHFFFAOYSA-M sodium;benzenesulfonate Chemical compound [Na+].[O-]S(=O)(=O)C1=CC=CC=C1 MZSDGDXXBZSFTG-UHFFFAOYSA-M 0.000 description 1
- 239000002689 soil Substances 0.000 description 1
- 239000004334 sorbic acid Substances 0.000 description 1
- 235000010199 sorbic acid Nutrition 0.000 description 1
- 229940075582 sorbic acid Drugs 0.000 description 1
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- 230000009885 systemic effect Effects 0.000 description 1
- 231100000820 toxicity test Toxicity 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 235000013311 vegetables Nutrition 0.000 description 1
- 230000017260 vegetative to reproductive phase transition of meristem Effects 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/56—1,2-Diazoles; Hydrogenated 1,2-diazoles
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/48—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with two nitrogen atoms as the only ring hetero atoms
- A01N43/54—1,3-Diazines; Hydrogenated 1,3-diazines
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N47/00—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid
- A01N47/08—Biocides, pest repellants or attractants, or plant growth regulators containing organic compounds containing a carbon atom not being member of a ring and having no bond to a carbon or hydrogen atom, e.g. derivatives of carbonic acid the carbon atom having one or more single bonds to nitrogen atoms
- A01N47/10—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof
- A01N47/24—Carbamic acid derivatives, i.e. containing the group —O—CO—N<; Thio analogues thereof containing the groups, or; Thio analogues thereof
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
The invention discloses a compound agricultural bactericide containing penthiopyrad and application thereof. The invention relates to a compound agricultural sterilization composition, which consists of an active component A and an active component B; the active component A is penthiopyrad; the active component B is pyraclostrobin or bupirimate. The compound agricultural bactericide keeps the self-sterilization advantages of two active components, has obvious synergistic effect, can obviously improve the control effects of treatment and protection, reduces the frequency of medication, has high safety on crops, and reduces the use cost.
Description
Technical Field
The invention relates to a compound bactericide containing penthiopyrad, belonging to the technical field of agricultural bactericides.
Background
Penthiopyrad (pentaiodopyrad), chemical name: (RS) -N- [2- (1, 3-dimethylbutyl) -3-thiophenyl ] -1-methyl-3- (trifluoromethyl) -1H-pyrazole-4-carboxamide, which is a novel pyrazole amide bactericide developed by Mitsui chemical company of Japan, is a pathogen mitochondrial respiration inhibitor, acts on a protein complex II on a pathogen mitochondrial respiration electron transfer chain, namely Succinate Dehydrogenase (SDH) or succinate-ubiquinone reductase (SQR), causes tricarboxylic acid cycle disorder, inhibits energy metabolism of the pathogen, inhibits the growth of the pathogen and causes death of the pathogen, and achieves the purpose of preventing and treating diseases (the SDHI bactericide is also named as an action mechanism).
Penthiopyrad has different bactericidal spectrums from the existing carboxamide bactericides, is mainly applied to field crops such as rape, peanut, sunflower, potato, soybean and the like, and is also applied to markets of fruit trees, vegetables and the like; preventing and treating various diseases such as streptosporic leaf blight, powdery mildew, gray mold, leaf spot, brown rot, rhizoctonia disease, sclerotinia rot and the like, and being safe to crops; it is also recommended for the control of gray mold and powdery mildew which are resistant to other fungicides.
Pyraclostrobin is a broad-spectrum methoxy acrylic acid snore bactericide, and is mainly used for preventing and treating various diseases caused by fungi on crops. Bupirimate is a super systemic pyrimidine fungicide, and has special effect on powdery mildew of various crops. However, these two kinds of agricultural chemicals are continuously applied at a high dose for a long period of time, and thus, there are problems such as the residue of the agricultural chemicals, environmental pollution, and the development of resistant fungi. Therefore, the reasonable chemical bactericide is selected for compounding or blending, has the positive characteristics of expanding the bactericidal spectrum, improving the control effect, prolonging the application period, reducing the dosage, reducing the phytotoxicity, reducing the residue, delaying the occurrence and the development of the drug resistance and the like, and the bactericide compounding is one of the most effective methods for solving the problems. In addition, as the price of developing new products of bactericides is continuously rising, compared with the prior art, the combination of developing and researching high-efficiency, low-toxicity and low-residue compound and mixed bactericides has the advantages of low investment and short development period, is emphasized at home and abroad, and the development and development strength of various enterprises is greatly increased.
In the actual process of agricultural production, the most easily generated problem of preventing and controlling diseases is the generation of the drug resistance of the diseases. The compounding of different kinds of components is a common method for preventing and treating resistant diseases. Different components are compounded, and whether a certain compound has synergism, addition or antagonism is judged according to the actual application effect. In most cases, the sterilization compounding effect is additive effect, the compounding with real synergistic effect is very little, and especially the compounding with very obvious synergistic effect and very high synergistic ratio is less.
Disclosure of Invention
Based on the situation, the invention aims to provide the compound bactericide containing penthiopyrad, which is prepared by compounding two bactericides with different structures, has the advantages of obvious synergistic action, low use cost, excellent control effect, no resistance and the like, and is mainly applied to control of gray mold and powdery mildew of crops.
In order to achieve the purpose, the invention adopts the technical scheme that:
in a first aspect, the invention provides a compound agricultural bactericidal composition, which consists of an active component A and an active component B;
the active component A is penthiopyrad;
the active component B is pyraclostrobin or bupirimate.
In the compound agricultural bactericidal composition, the mass ratio of the active component A to the active component B is 1: 0.1-1: 50, such as 1: 0.5-1: 2 or 1: 0.1-1: 20.
preferably, the mass ratio of the active component A to the active component B is 1: 0.2-1: 5.
further preferably, the active component B is pyraclostrobin; the mass ratio of the active component A to the active component B is 1: 1.5.
further preferably, the active component B is bupirimate; the mass ratio of the active component A to the active component B is 1:1.
in a second aspect, the invention provides an application of the compound agricultural bactericidal composition in preventing and treating gray mold and/or powdery mildew of crops.
In a third aspect, the invention provides a compound agricultural bactericide, which is prepared from any one of the compound agricultural bactericide compositions and auxiliary materials acceptable for pesticide preparations, wherein the mass percentage of the compound agricultural bactericide composition is 1-90%. Preferably, the mass percentage of the compound agricultural bactericidal composition is 20-50%, such as 30%, 29% or 32%.
Furthermore, the agricultural bactericidal composition can be prepared into any one of formulations which can be applied in agriculture by adding an auxiliary agent and an excipient according to the requirement of actual production, and preferably, the formulation of the compound agricultural bactericide can be any one of a suspending agent, an aqueous emulsion, a dispersible oil suspending agent, a wettable powder, a water dispersible granule, an emulsifiable concentrate and a microemulsion.
The compound agricultural bactericide is a suspending agent and comprises the following components in percentage by mass: 1-40% of penthiopyrad, 1-40% of an active component B, 2-10% of a dispersant, 1-5% of a wetting agent, 2-10% of an antifreezing agent, 0.1-1% of an antifoaming agent, 0.1-3% of a thickening agent, 0.1-2% of a preservative, and the balance of water;
preferably, the composition comprises the following components in percentage by mass: 1-20% of penthiopyrad, 1-20% of the component B, 2-6% of a dispersant, 1-2% of a wetting agent, 2-5% of an antifreezing agent, 0.1-0.2% of an antifoaming agent, 0.1-0.2% of a thickening agent, 0.1-0.2% of a preservative, and the balance of water;
by way of example, the composition comprises the following components in percentage by mass: penthiopyrad 12%, component B18%, dispersant 3%, wetting agent 1%, antifreezing agent 5%, defoaming agent 0.5%, thickening agent 0.1%, preservative 0.1%, and the balance of water.
The compound agricultural bactericide is an aqueous emulsion and comprises the following components in percentage by mass: 1-40% of penthiopyrad, 1-40% of component B, 2-10% of dispersant, 1-5% of emulsifier, 10-30% of organic solvent, 2-10% of antifreezing agent, 0.1-1% of defoaming agent, 0.1-3% of thickening agent, 0.1-2% of preservative and the balance of water;
preferably, the composition comprises the following components in percentage by mass: 1-20% of penthiopyrad, 1-20% of the component B, 2-10% of a dispersant, 1-3% of an emulsifier, 10-15% of an organic solvent, 2-5% of an antifreezing agent, 0.1-0.2% of an antifoaming agent, 0.1-0.2% of a thickener, 0.1-0.2% of a preservative and the balance of water;
by way of example, the composition comprises the following components in percentage by mass: 14.5% of penthiopyrad, 14.5% of the component B, 3% of a dispersant, 3% of an emulsifier, 15% of an organic solvent, 5% of an antifreezing agent, 0.2% of an antifoaming agent, 0.2% of a thickening agent, 0.2% of a preservative, and the balance of water; or the like, or, alternatively,
the composition comprises the following components in percentage by mass: 25% of penthiopyrad, 5% of the component B, 3% of a dispersant, 3% of an emulsifier, 20% of an organic solvent, 5% of an antifreezing agent, 0.2% of a defoaming agent, 0.2% of a thickening agent, 0.2% of a preservative, and the balance of water.
The compound agricultural bactericide is a dispersible oil suspending agent and comprises the following components in percentage by mass: 1-40% of penthiopyrad, 1-5% of a component B1-40%, 1-5% of a dispersant, 5-20% of an emulsifier, 1-5% of a thickener and the balance of an oil medium;
preferably, the composition comprises the following components in percentage by mass: 1-20% of penthiopyrad, 1-20% of the component B, 1-5% of a dispersant, 5-15% of an emulsifier, 1-5% of a thickening agent and the balance of an oil medium;
by way of example, the composition consists of the following components in percentage by mass: 17.5% of penthiopyrad, 12.5% of the component B, 1% of a dispersant, 6% of an emulsifier, 2% of a thickening agent and the balance of an oil medium; or the like, or, alternatively,
the composition comprises the following components in percentage by mass: 20% of penthiopyrad, 10% of a component B, 2% of a dispersant, 5% of an emulsifier, 3% of a thickening agent and the balance of an oil medium.
The compound agricultural bactericide is wettable powder and comprises the following components in percentage by mass: 1-40% of penthiopyrad, 3-10% of a dispersant, 1-5% of a wetting agent and the balance of a filler, wherein the component B1 is 1%;
preferably, the composition comprises the following components in percentage by mass: 1-20% of penthiopyrad, 1-20% of component B, 5-10% of a dispersant, 1-5% of a wetting agent and the balance of a filler;
by way of example, the composition consists of the following components in percentage by mass: the penthiopyrad-containing water dispersible granule comprises 10% of penthiopyrad, 20% of component B, 7% of a dispersing agent, 3% of a wetting agent and the balance of a filler.
The compound agricultural bactericide is a water dispersible granule which comprises the following components in percentage by mass: 1-40% of penthiopyrad, 1-40% of component B, 1-10% of dispersant, 1-5% of wetting agent and the balance of filler;
preferably, the composition comprises the following components in percentage by mass: 1-20% of penthiopyrad, 1-20% of the component B, 1-10% of a dispersant, 1-5% of a wetting agent and the balance of a filler;
by way of example, the composition comprises the following components in percentage by mass: 24% of penthiopyrad, 8% of the component B, 7% of a dispersant, 4% of a wetting agent and the balance of a filler; or the like, or, alternatively,
the composition comprises the following components in percentage by mass: 15% of penthiopyrad, 7% of the component B, 7% of a dispersant, 4% of a wetting agent and the balance of a filler.
The compound agricultural bactericide is missible oil and comprises the following components in percentage by mass: 1-40% of penthiopyrad, 1-40% of component B1, 1-10% of emulsifier and the balance of organic solvent;
preferably, the composition comprises the following components in percentage by mass: 1-20% of penthiopyrad, 1-20% of component B, 1-10% of emulsifier and the balance of organic solvent.
The compound agricultural bactericide is microemulsion which comprises the following components in percentage by mass: 1-40% of penthiopyrad, 1-40% of the component B, 5-25% of an organic solvent, 15-25% of an emulsifier and the balance of water;
preferably, the composition comprises the following components in percentage by mass: 1-20% of penthiopyrad, 1-20% of a component B, 5-25% of an organic solvent, 15-25% of an emulsifier and the balance of water;
by way of example, the composition comprises the following components in percentage by mass: 15% of penthiopyrad, 15% of a component B, 25% of an organic solvent, 20% of an emulsifier and the balance of water.
The various adjuvants in the above formulation are as follows:
the dispersing agent is selected from one or a mixture of more than two of naphthalene formaldehyde condensate sulfonate, alkyl naphthalene formaldehyde condensate sulfonate, fatty alcohol ethylene oxide adduct sulfonate, alkylphenol polyoxyethylene ether sulfonate, lignin and derivative sulfonate, polymerized alkylaryl sulfonate, alkylphenol polyoxyethylene ether formaldehyde condensate sulfate, fatty alcohol polyoxyethylene ether sulfate, fatty alcohol ethane adduct phosphate, alkylphenol polyoxyethylene phosphate, polyacrylate, polyacrylic acid and maleic anhydride copolymer salt (or ester), EO-PO block copolymer, hydroxystearic acid and alkyl glycol block copolymer.
The wetting agent is selected from one or a mixture of more than two of sodium dodecyl sulfate, sodium dodecyl benzene sulfonate, sodium triisopropyl naphthalene sulfonate, sodium diisobutyl naphthalene sulfonate, dioctyl sodium sulfosuccinate, fatty alcohol polyoxyethylene ether sulfate, alkylphenol polyoxyethylene ether sulfosuccinate and fatty alcohol polyoxyethylene ether (normal or isomeric).
The emulsifier is selected from one or a mixture of more than two of alkylphenol polyoxyethylene ether, benzyl phenol polyoxyethylene ether, phenethyl phenol polyoxyethylene ether phosphate, fatty alcohol polyoxyethylene ether, phenethyl phenol polyoxyethylene ether polyoxypropylene ether, castor oil polyoxyethylene ether, alkylphenol polyoxyethylene ether formaldehyde condensate, polyoxyethylene sorbitan monooleate, sorbitan fatty acid ester, polyethylene glycol oleate, sorbitol polyoxyethylene ether oleate and dodecyl benzene sulfonate (calcium salt or isopropyl amine salt).
The antifreezing agent is one or a mixture of more than two of ethylene glycol, propylene glycol, glycerol, polyethylene glycol, urea, sorbitol and inorganic salt.
The defoaming agent is selected from one or a mixture of more than two of organic silicone, C8-10 fatty alcohol, C19-20 saturated aliphatic carboxylic acid and esters and ester-ether compounds thereof.
The thickening agent is one or a mixture of more than two of xanthan gum, Arabic gum, methylcellulose, sodium carboxymethylcellulose, hydroxypropyl cellulose, sodium acrylate, polyvinyl alcohol, polyvinylpyrrolidone, sodium polyacrylate, polyvinyl acetate, dispersed silicic acid, fumed silica, organic bentonite and magnesium aluminum silicate.
The preservative is selected from one or a mixture of more than two of sodium benzoate, sorbic acid, sodium salicylate, carbazone, benziothiazolinone and phenoxyethanol.
The organic solvent is one or a mixture of more than two of cyclohexanone, N-dimethylformamide, N-dimethyldecanamide, N-dimethyloctadecanamide, N-methylpyrrolidone, N-octylpyrrolidone, dibasic ester and aromatic solvent oil.
The oil medium is selected from one or more of soybean oil, rapeseed oil, cottonseed oil, corn oil, castor oil, palm oil, epoxidized soybean oil, diesel oil, methyl esterified vegetable oil, engine oil and mineral oil.
The filler is selected from one or a mixture of more than two of diatomite, attapulgite, light calcium carbonate, sepiolite, kaolin, white carbon black, talcum powder, montmorillonite, corn starch and ammonium sulfate.
In a fourth aspect, the invention protects the application of any one of the compound agricultural fungicides in preventing and treating gray mold or powdery mildew of crops.
In the above application, the crop may be strawberry, melon or tomato.
The compound agricultural bactericide is applied to crops or crop parts by spraying, root irrigation or seed dressing.
The inventor discovers through long-term research that the penthiopyrad and the pyraclostrobin are compounded to be used for controlling gray mold of crops, and the penthiopyrad and the bupirimate are compounded to be used for controlling powdery mildew of the crops, so that the penthiopyrad and the bupirimate have obvious synergistic effect and no resistance compared with a corresponding single agent after being compounded. In addition, the report on the combination of penthiopyrad and pyraclostrobin or bupirimate is very few, and the application has very important significance for expanding the application of the penthiopyrad-containing compound product.
Compared with the prior art, beneficial effect lies in:
the penthiopyrad and one of pyraclostrobin or bupirimate are compounded, the self-sterilization advantages of two active components are kept, the remarkable synergistic effect is achieved, the prevention and control effects of treatment and protection can be obviously improved, the medicine taking frequency is reduced, the safety to crops is high, the use cost is reduced, the pathogenic bacteria are not prone to generating drug resistance due to the compounding of the two components with different action mechanisms, and the risk of the pathogenic bacteria generating drug resistance to a single agent is delayed.
Detailed Description
The present invention is described in further detail below with reference to specific embodiments, which are given for the purpose of illustration only and are not intended to limit the scope of the invention. The examples provided below serve as a guide for further modifications by a person skilled in the art and do not constitute a limitation of the invention in any way.
The experimental methods used in the following examples are all conventional methods unless otherwise specified; the materials, reagents and the like used are commercially available unless otherwise specified.
Examples of biological Activity
This example is used to illustrate the synergistic effect of the penthiopyrad-containing compound bactericidal composition provided by the present invention.
Through a large number of screening tests, the inventor respectively performs synergistic action analysis of different proportions on the penthiopyrad, pyraclostrobin and bupirimate binary compound bactericide composition by using a Sun cloud Peel method, and finds that the penthiopyrad and pyraclostrobin composition has an obvious synergistic action on gray mold of crops in a certain proportion range; the composition of penthiopyrad and bupirimate has an obvious synergistic effect on powdery mildew of crops. This potentiation is not simply the addition of the two agents and is illustrated in the following bioassay examples.
Biological activity example 1, indoor bioassay of gray mold of strawberry by compounding penthiopyrad and pyraclostrobin.
Test strains: the strawberry botrytis cinerea is collected from a strawberry planting greenhouse in Nanchang city, and is separated and purified to obtain the bactericide and a compound agent thereof (Zhang Mibo, easy germination, Sun Yun, and the like.) for measuring the indoor toxicity of the bactericide and the compound agent on the strawberry botrytis cinerea [ J ]. Hubei agricultural science, 2013,52(14): 3299-.
Reagent to be tested: 99.5 percent of penthiopyrad technical material and 97.5 percent of pyraclostrobin technical material. The raw materials are all provided by Zhongnong li hua biotechnology limited.
The test method comprises the following steps:
the plate hypha growth inhibition method is adopted. And preparing 2500 mu g/mL of mother liquor of penthiopyrad and pyraclostrobin by using dimethyl sulfoxide, wherein the mother liquor is 50mL, and diluting the mother liquor by using 0.05% Tween-80 water. On the basis of the preliminary experiment, the ratio of the raw materials is calculated according to the following ratio of 2: 1,1.5: 1,1: 1,1: 1.5,1: 2 to finally prepare the PDA culture medium containing the medicines with the concentration gradient of 1, 5, 10, 20 and 30 mug/mL for the single medicine and the mixed medicine.
The activity of penthiopyrad and pyraclostrobin on gray mold of strawberry is measured by using a growth rate method, under the aseptic operation condition, a bacterial cake with the diameter of 5mm is taken from the edge of a bacterial colony of gray mold of strawberry by using a sterilization puncher, the hypha face is downwards inoculated on a PDA culture medium containing medicines, each bacterial cake is subjected to inverted culture at the temperature of 25 ℃, 3 times of treatment are repeated, and a flat plate containing dimethyl sulfoxide is used as a reference. When the growth diameter of the hyphae of the control group reaches about 50% of the diameter of the culture dish, the colony diameter is measured by a cross method, and the (relative) bacteriostasis rate is calculated. By means of SPSS software, the logarithm value of the concentration of the medicine is used as the abscissa (x), the value of the hypha growth inhibition rate is used as the ordinate (y), and the toxicity regression equation and EC are obtained 50 And correlation coefficient, calculating the synergy coefficient (SR) of the mixture according to the Wadley method, and evaluating the combined action type of the mixture. See table 1.
Table 1: penthiopyrad and pyraclostrobin and indoor toxicity determination method for strawberry gray mold through combination of penthiopyrad and pyraclostrobin
As can be seen from the test results in Table 1, compared with the treatment of 97.5% pyraclostrobin original drug, 99.5% penthiopyrad original drug has more remarkable growth inhibition effect on gray mold of strawberry. 5 different blending combinations of penthiopyrad and pyraclostrobin have good inhibition effect on gray mold pathogen of strawberry, and the activity is ideal. Wherein penthiopyrad and pyraclostrobin are mixed according to the weight ratio of 1:1.5 EC of compounding combination 50 The effective dose is 13.93 mu g/mL, the synergistic coefficient SR is 1.65, the inhibition effect is better than that of two single doses, and the synergistic effect is most obvious; EC of other 4 proportions 50 These values were 13.15. mu.g/mL, 16.99. mu.g/mL, 19.29. mu.g/mL and 16.78. mu.g/mL, respectively, and they were all shown to be additive.
Biological activity example 2, indoor bioassay of strawberry powdery mildew by compounding penthiopyrad and bupirimate.
Reagent to be tested:
99.5 percent of penthiopyrad technical material and 95.2 percent of bupirimate technical material. The raw materials are all provided by Zhongnong li hua biotechnology limited.
Test target
The method is characterized in that penthiopyrad and bupirimate are never applied in Changfeng county of Anhui, and the strawberry in the same type is collected and separated in a potted plant, and the strawberry varieties to be tested are as follows: and (4) a flange.
The test method comprises the following steps:
dissolving the raw materials with acetone, mixing two raw materials at different ratios according to the results of the preliminary experiment, and diluting with acetone to obtain several concentration gradients. The method comprises the steps of cultivating susceptible strawberry varieties in seedling pots in a flange mode, placing the seedlings in a greenhouse for cultivation, collecting leaves with the same leaf age after the plants enter a flowering period, and using the leaves for cultivation and determination of powdery mildew of strawberries.
Culture of strawberry powdery mildew and preparation of spore suspension
The strawberry powdery mildew is cultured by a living plant method under the condition of light-dark alternation at 20 ℃ for 12h, and is subcultured for 1 time every 30 days. During inoculation, conidia on diseased leaves are eluted with sterile water to prepare spores with the concentration of 1 × 10 6 Suspension per mL.
Determination of sensitivity of test strains
Toxicity determination is carried out by adopting a leaf disc moisturizing method. Firstly, preparing collected leaves into leaf discs with the diameter of 1.5cm, randomly and uniformly mixing, respectively soaking the leaf discs in liquid medicine with the prepared series concentration for lh, wherein each leaf disc has the concentration of 50, the test takes the treatment without adding a medicament as a blank control, after the soaking is finished, the leaves are placed on absorbent paper with the same liquid medicine concentration in an upward mode, the liquid medicine on the leaf discs is sucked to be dry, 10L of prepared spore suspension is inoculated to the centers of the leaf discs, the leaf discs are placed at room temperature for 5min and then cultured under the condition of light-dark alternation of 20 ℃ and 12h, the disease incidence area on the leaf discs is measured after 10 days, and the EC is calculated 50 。
On the basis of the preliminary test, single dose penthiopyrad and bupirimate are respectively subjected to toxicity measurement by the method, and EC of the single dose penthiopyrad and bupirimate are measured 50 The values were 7.213mg/L and 7.840mg/L, respectively.
Dividing the disease grade according to the percentage of the lesion area to the leaf disc area
Level 0: no disease;
level 1: the spore heap area accounts for less than 5% of the whole leaf area;
and 3, stage: the spore heap area accounts for less than 6-10% of the whole leaf area;
and 5, stage: the area of the spore heap accounts for less than 11-20% of the area of the whole leaf;
and 7, stage: the spore heap area accounts for less than 21-50% of the whole leaf area;
and 9, stage: the area of the sporophyte accounts for more than 50% of the whole leaf area.
Mixture toxicity determination and result analysis
The toxicity of the mixed preparation is determined by a single-preparation toxicity determination method according to the mixing proportion.
If the control mortality is less than 5 percent, the control mortality is not corrected, the control mortality is between 5 and 20 percent, the control mortality is corrected according to a formula and is more than 20 percent, and the test needs to be redone.
Respectively establishing virulence regression equations with logarithmic value of medicament concentration (mg/L) as independent variable x and several values of corrected mortality as dependent variable y, and calculating EC of single dose and mixed dose by DPS software 50 The co-toxicity coefficient (CTC) was calculated according to the grandson method. The co-toxicity coefficient CTC is calculated according to the following formula: (penthiopyrad is used as a standard medicament, and the virulence index of the penthiopyrad is 100):
toxicity Index (TI) of bupirimate EC 50 EC of bupirimate 50 ×100；
True virulence index (ATI) of M ═ EC of penthiopyrad 50 EC of/M 50 ×100；
The theoretical virulence index (TTI) of M is TI x P penthiopyrad of penthiopyrad + TI x P bupirimate of bupirimate;
co-toxicity coefficient (CTC) of M-TTI × 100 of ATI/M of M;
in the formula:
m is a mixture of penthiopyrad and bupirimate in different proportions;
p bupirimate is the proportion of bupirimate in the mixture;
the penthiopyrad is the proportion of penthiopyrad in the mixture.
Virulence assay results were as follows:
table 2: indoor toxicity determination result of penthiopyrad and bupirimate combination on strawberry powdery mildew
Indoor toxicity test results show that: when the penthiopyrad and the bupirimate are mixed, the pesticide composition has a good control effect on strawberry powdery mildew pathogenic bacteria, and particularly, the pesticide composition has the following effects that: bupirimate is prepared from the following raw materials in a mass ratio of 24: 24, namely 1: the synergistic effect is most obvious when 1 is used.
Formulation examples
Formulation example 1, 30% penthiopyrad pyraclostrobin suspension
Weighing 12% of penthiopyrad, 18% of pyraclostrobin, 3% of a dispersant Morwet D-425 (alkyl naphthalene formaldehyde condensate sulfonate, Akzo Nobel), 3% of a wetting agent Genapol X080 (isomeric alcohol polyoxyethylene ether, Solvay), 5% of 1, 2-propylene glycol (an antifreezing agent, Shandong national chemical Co., Ltd.), 0.1% of xanthan gum (a thickening agent, Hebei Pengyu Biotech Co., Ltd.), 0.1% of Kathon (a preservative, Beijing Guangyuan agricultural chemical Co., Ltd.), 0.5% of SAG 1522 (an organic silicon defoaming agent, Mitigo high and new materials group) and deionized water (self-made) to make up 100% by mass. The raw materials are mixed, sand milled by a sand mill until the grain diameter is less than 5 mu m, and filtered to obtain the 30 percent penthiopyrad-pyraclostrobin suspending agent.
Formulation example 2, 30% penthiopyrad-pyraclostrobin wettable powder
Weighing 10% of penthiopyrad, 20% of pyraclostrobin and a dispersing agent in percentage by mass
NN8906 (naphthalene formaldehyde condensate sulfonate, BASF) 7%, wetting agent geopon SDS (dioctyl sodium sulfosuccinate, Solvay) 3%, filler SIPERNAT 22LS (white carbon black, EVONIK) 7%, filler Celite 499 (diatomaceous earth, Imerys) to make up 100%. After the raw materials are mixed, the raw materials are crushed by a jet mill and then are uniformly mixed, and the 30 percent penthiopyrad-pyraclostrobin wettable powder is obtained.
Formulation example 3, 30% penthiopyrad pyraclostrobin water dispersible granule
Weighing 15% of penthiopyrad, 15% of pyraclostrobin, 7% of dispersant Superex K powder (Naphthaldehyde condensate sulfonate dispersant, Switzerland Ohio chemical Co., Ltd.), 4% of wetting agent sodium dodecyl sulfate (Tomingtie Co., Ltd.), 20% of corn starch (filler, Linyita Longyu Co., Ltd.), and 100% of filler MXK201 (calcined kaolin, Nemontage Mongolia Monghee Kaolin Co., Ltd.). After the raw materials are mixed, the mixture is crushed by a jet mill and then is uniformly mixed, kneaded, granulated, dried and screened, and then the 30% penthiopyrad-pyraclostrobin water dispersible granule is obtained.
Formulation example 4, 30% penthiopyrad-pyraclostrobin dispersible oil-suspension concentrate
Weighing 20% of penthiopyrad, 10% of pyraclostrobin, 6% of emulsifier Emulsogen EL360 (castor oil polyoxyethylene ether, Clariant), 5% of emulsifier Phenylfonat CAL (calcium dodecylbenzenesulfonate, Clariant), 2% of dispersant Atlox Metaperse 550S (polyacrylate, Croda), 3% of thickener ODGel-04 (organic soil, Zhejiang Fenghong new material Co., Ltd.), and 100% of dispersion medium methyl oleate 0295 (Suzhou Fengdong biological science Co., Ltd.). The raw materials are mixed, sand milled by a sand mill until the particle size is less than 5 mu m, and filtered to obtain the 30% penthiopyrad-pyraclostrobin dispersible oil suspending agent.
Formulation example 5, 29% penthiopyrad-pyraclostrobin aqueous emulsion
Weighing 14.5% of penthiopyrad, 14.5% of pyraclostrobin, 15% of solvent oil S-150# (Jiangsu Hualun chemical Co., Ltd.), 3% of dispersant Soprophor SC (alkylphenol polyoxyethylene phosphate, Solvay), 3% of emulsifier EL-40 (castor oil polyoxyethylene ether, Jiangsu Haian petrochemical Co., Ltd.), 5% of antifreeze urea (chemical fertilizer control Co., Ltd.), 0.2% of defoamer Sag 630 (organic silicone, Michigan high and new material group), 0.2% of thickener xanthan gum (Shanghai Wan chemical industry Co., Ltd.), 0.2% of preservative Kathon (Beijing Guangyuan agricultural chemical responsibility Co., Ltd.), and the balance of water to 100% by mass. Dissolving penthiopyrad and pyraclostrobin in solvent oil to form an oil phase, mixing the rest components with water to form a water phase, slowly adding the oil phase into the high-speed sheared water phase in batches, homogenizing, emulsifying and filtering to obtain the 29% penthiopyrad-pyraclostrobin aqueous emulsion.
Formulation example 6, 30% penthiopyrad bupirimate dispersible oil suspension
Weighing 17.5% of penthiopyrad, 12.5% of bupirimate, 6% of emulsifier Emulsogen TS200 (phenethyl phenol polyoxyethylene ether phosphate, Clariant), 6% of emulsifier Zephrym 3300B (isopropyl dodecylbenzene sulfonate, Croda), 1% of dispersant YUS-EP60P (alkylphenol polyoxyethylene ether sulfosuccinate, TakeMOTO), 2% of thickener AEROSIL R974 (white carbon black, EVONIK) and 100% of soybean oil (Yihaijiali group) in percentage by mass. The raw materials are mixed, sand milled by a sand mill until the particle size is less than 5 mu m, and filtered to obtain the 30% penthiopyrad-bupirimate dispersible oil suspending agent.
Formulation example 7, 30% penthiopyrad bupirimate emulsion in water
Weighing 25% of penthiopyrad, 5% of bupirimate, 20% of solvent oil S-200# (Jiangsu Hualun chemical Co., Ltd.), 3% of dispersing agent TERSPERSE2020 (alkyl naphthalene sulfonate, Huntsman), 3% of emulsifier ATLAS G-1086 (sorbitol polyoxyethylene ether oleate, Croda), 5% of antifreezing agent urea (chemical fertilizer control Co., Ltd.), 0.2% of defoaming agent Sag 630 (organic silicone, Megaku, New Material group), 0.2% of thickening agent xanthan gum (Shanghai Wan chemical Co., Ltd.), 0.2% of preservative Kathon (Beijing Guangyuan agricultural chemical Co., Ltd.), and water for making up 100% by mass. Dissolving penthiopyrad and bupirimate in solvent oil to form an oil phase, mixing the rest components with water to form a water phase, slowly adding the oil phase into the high-speed sheared water phase in batches, homogenizing, emulsifying and filtering to obtain the 30% penthiopyrad-bupirimate emulsion in water.
Formulation example 8, 30% penthiopyrad bupirimate microemulsion
Weighing 15% of penthiopyrad, 15% of bupirimate, 25% of solvent N, N-dimethyloctyldecanamide (Hubei Chengfeng chemical Co., Ltd.), 20% of emulsifier Tween-20 (polyoxyethylene sorbitan monooleate, Jiangsu province Heian petrochemical plant) and water in a balance of 100% by mass. Dissolving penthiopyrad and bupirimate in an organic solvent, adding an emulsifier, uniformly stirring, finally adding water, and uniformly stirring to obtain the 30% penthiopyrad-bupirimate microemulsion.
Formulation example 9, 30% penthiopyrad bupirimate wettable powder
Weighing 20% of penthiopyrad, 10% of bupirimate, 7% of dispersing agent TERSPERSE2020 (alkyl naphthalene sulfonate, Huntsman), 3% of wetting agent Geropon SDS (dioctyl sodium sulfosuccinate, Solvay), 8% of filler SIPERNAT 22LS (white carbon black, EVONIK,), and MXK 201% of filler 35201 (calcined kaolin, Nemontmory montmorillonite Co., Ltd.) to make up to 100% by mass. After the raw materials are mixed, the raw materials are crushed by a jet mill and then are uniformly mixed, and the 30 percent penthiopyrad-bupirimate wettable powder is obtained.
Formulation example 10, 32% penthiopyrad bupirimate water dispersible granule
Weighing 24% of penthiopyrad, 8% of bupirimate, 7% of SUPRAGIL GN (naphthalene formaldehyde condensate sulfonate dispersant, Solvay) as a dispersant, 4% of sodium dodecyl sulfate as a wetting agent (Toming Softyu Biotech Co., Ltd.), 20% of ammonium sulfate as a filler (Shandong Mitsu Biotech Co., Ltd.), and MXK201 (calcined kaolin, Nemontage Mongolia Kaolin Co., Ltd.) to make up 100% by mass. After the raw materials are mixed, the raw materials are crushed by a jet mill and then uniformly mixed, kneaded, granulated, dried and screened, and then the 32% penthiopyrad-pyraclostrobin water dispersible granule is obtained.
Examples of the effects of the field
Field Effect example 1, field Effect example of strawberry Gray mold
Reagent to be tested: selecting a mixture of penthiopyrad and pyraclostrobin prepared in preparation examples 1-5;
20% penthiopyrad suspension (mitsui chemical AGRO co., ltd.);
25% pyraclostrobin suspension concentrate (Shandong Kangqiao Biotech, Inc.);
the test is carried out in Hebei Baocheng Mancheng strawberry base to verify the control effect of each mixed medicament on the gray mold of strawberryAnd (5) fruit. The test crop is strawberry, and the variety is pennisetum. The test agent and the dosage are shown in Table 3, the cell treatment of the test agent, the control agent and the blank control adopts random block arrangement, and the area of the cell is 30m 2 The disease condition base is investigated before the medicine application for 4 times, the medicine application is carried out for two times, and the prevention and treatment effects are investigated before each medicine application and 7 days and 15 days after the last medicine application. Four points are randomly selected for investigation in each cell, two plants are investigated in each point, and all leaves are investigated in each plant. The disease index was calculated and the results are shown in table 3.
Grading method (in blade unit)
No disease spot at 0 level;
the lesion area of grade 1 is less than 5% of the whole leaf area;
3, the lesion area accounts for 6 to 10 percent of the whole leaf area;
5 grade, the scab area accounts for 11 to 25 percent of the whole leaf area;
7 grade, the lesion area accounts for 26 to 50 percent of the whole leaf area;
grade 9, the lesion area accounts for more than 50% of the whole leaf area.
Method for calculating drug efficacy
Safety investigations and effects on other organisms: on the first day after each spraying and several days after each spraying, the influence of each treatment of the medicament on the growth of strawberries and other diseases is observed.
Table 3 field efficacy experiment results of penthiopyrad and pyraclostrobin mixture for preventing and treating gray mold of strawberry
Safety of strawberries is investigated, and during the test period, the phenomenon that each treatment agent does not cause phytotoxicity to strawberry stems and leaves is observed and found.
The field test results in table 3 show that, compared with the single agents of penthiopyrad and pyraclostrobin, the compound of penthiopyrad and pyraclostrobin has a good control effect on gray mold of strawberry by taking clear water as a control, and when the mass ratio of penthiopyrad to pyraclostrobin is 1:1.5, the control effect on gray mold of strawberry is the best. The combination of the two not only reduces the dosage and the cost of the drug, but also is safe to the growth of the strawberries.
Field efficacy example 2, field efficacy example of strawberry powdery mildew
Reagent to be tested: selecting a mixture of penthiopyrad and bupirimate prepared in preparation examples 6-10;
20% penthiopyrad suspension (mitsui chemical AGRO corporation, japan);
a microemulsion of 25% bupirimate (west ampere near technology industries, ltd).
The test was conducted in strawberry base at Zhao Tunxiang province of Qingpu, Shanghai, to verify the control effect of each mixed drug on strawberry powdery mildew. The test crop is strawberry, and the variety is Xintun I. The test method refers to the GB/T17980.119-2004 pesticide field efficacy test criterion (pesticide efficacy test for preventing and treating strawberry powdery mildew with bactericide). The test agents and the dosages are detailed in table 4. Another blank control was set, each treatment was repeated 4 times, with 20 strawberries per plot, for a total of 48 plots, and arranged in random blocks. The whole plant is uniformly sprayed by adopting a conventional spraying method. The application for the 1 st time is carried out at the early stage of strawberry powdery mildew, and the application for the second time is carried out 14 days later, and the application is carried out for 2 times in total.
The investigation and statistical method comprises the following steps:
disease indexes are investigated 14 days after the first medicine and 14 days after the second medicine, 5 points are investigated randomly in each cell, all leaves of 3 plants are investigated in each point, each leaf is recorded according to the percentage of scabs in the leaf area in a grading manner, the total leaf number and the leaf number of each grade of disease are recorded and investigated, the disease indexes are calculated, and the results are shown in a table 4.
The grading standard is as follows:
level 0: no disease exists;
stage 1: the connection area of the disease spots accounts for less than 5 percent of the whole fruit area;
and 3, stage: the area of the connected disease spots accounts for 5 to 10 percent of the whole fruit area;
stage 5: the connection area of the disease spots accounts for 11 to 25 percent of the whole fruit area;
and 7, stage: the area of the connected disease spots accounts for 26-50% of the whole fruit area;
and 9, stage: the area of the connected disease spots accounts for more than 50 percent of the whole fruit area.
The calculation method of disease index and prevention and treatment effect comprises the following steps:
safety investigations and effects on other organisms: on the first day after each spraying and several days after each spraying, the influence of each treatment of the medicament on the growth of strawberries and other diseases is observed.
TABLE 4 field efficacy experiment results of penthiopyrad and bupirimate mixture for preventing and treating strawberry powdery mildew
Safety of strawberries is investigated, and during the test period, the phenomenon that each treatment agent does not cause phytotoxicity to strawberry stems and leaves is observed and found.
The field test results in table 4 show that, compared with penthiopyrad and bupirimate single agents, penthiopyrad and bupirimate have good control effects on strawberry powdery mildew by taking clear water as a control, and the control effects on strawberry powdery mildew are optimal when the mass ratio of penthiopyrad to bupirimate is 1:1. The combination of the two not only reduces the dosage and the cost of the medicine, but also is safe to the growth of the strawberries.
Field efficacy example 3 and field efficacy example of melon powdery mildew
Reagent to be tested: selecting a mixture of penthiopyrad and bupirimate prepared in preparation examples 6-10;
20% penthiopyrad suspension (mitsui chemical AGRO corporation, japan);
a microemulsion of 25% bupirimate (xi' an near-tech industries, ltd).
The test is carried out in facility warm sheds of Yan villages, township, city, leting county, and countryside, the cultivation conditions in the districts are uniform, and the melons and nectarines are planted in the peripheral fields. So as to verify the control effect of each mixed medicament on the powdery mildew of the melon. The test crop is melon, and the variety is classical. The test agents and the dosages are detailed in table 5, the cell treatments of the test agents, the control agents and the blank control are arranged in random blocks, and the area of the cell is as follows: 32m 2 . Repeat 3 times.
The pesticide is applied for 2 times, the interval period is about 7 days, and the front and back surfaces of the stems and the leaves are uniformly sprayed. The disease condition base was investigated before the application of the drug, the middle period was carried out before the second application, and the last was carried out 7 days after the second application. Four points are randomly selected in each cell, all the leaves of 2 plants are investigated at each point, each leaf is graded according to the percentage of the lesion area to the whole leaf area, the total leaf number and the lesion leaf number at each grade are recorded and investigated, the disease index is calculated, and the result is shown in table 5.
The grading method comprises the following steps:
level 0: no scab
Stage 1: the lesion area accounts for less than 5% of the whole leaf area;
and 3, level: the lesion area accounts for 6-10% of the whole leaf area;
stage 5: the lesion area accounts for 11 to 20 percent of the whole leaf area;
and 7, stage: the lesion area accounts for 21 to 40 percent of the whole leaf area;
9 stages; the lesion area accounts for more than 40% of the whole leaf area.
The efficacy calculation method comprises the following steps:
safety investigations and effects on other organisms: the influence of each treatment of the medicament on the growth of the melons and other diseases is observed on the first day after each pesticide spraying and a plurality of days after each pesticide spraying.
TABLE 5 field efficacy experiment result of penthiopyrad and bupirimate mixture for preventing and treating powdery mildew of melon
The safety of the melons is investigated, and during the test period, the phenomenon that each treatment agent does not cause chemical injury to stems and leaves of the melons is observed and found.
The field test results in table 5 show that, compared with penthiopyrad and bupirimate single agents, penthiopyrad and bupirimate have good control effects on melon powdery mildew by taking clear water as a control, and the control effects on melon powdery mildew are optimal when the mass ratio of penthiopyrad to bupirimate is 1:1. The combination of the two not only reduces the dosage and the cost of the drug, but also is safe to the growth of the melons.
Field Effect of tomato Gray mold example 4
Reagent to be tested: selecting a mixture of penthiopyrad and pyraclostrobin prepared in preparation examples 1-5;
20% penthiopyrad suspension (mitsui chemical AGRO corporation, japan);
25% pyraclostrobin suspension concentrate (Shandong kang George Biotech Co., Ltd.);
the test was carried out in Zhangzhengbao village of class Wang street in Tubuhui province of Suzhongyuan, Shenyang, province of Liaoning, where there was a history of planting tomatoes for many years, and the tomato gray mold occurred throughout the year. So as to verify the control effect of each mixed medicament on the botrytis cinerea. The test crop is tomato and the variety is gardening winter treasure. The test agents and dosages are detailed in Table 6, and the treatment of the test agents, control agents and blank control cells was performed in a randomized block arrangementCell area 20m 2 The disease condition base is investigated before the application of the medicine, the medicine is applied twice, and the prevention and treatment effects are investigated before the application, 7 days after the first application and 10 days after the second application. And randomly surveying five points in each cell, wherein 2-3 plants are surveyed in each point, and all leaves are surveyed in each plant. The disease index was calculated and the results are shown in Table 6.
Tomato fruit damage grading method (taking fruit as unit):
level 0: no disease spots;
level 1: residual flower diseases;
and 3, level: onset of disease at the hilum of the fruit;
and 5, stage: the length of the disease spot is less than 10% of the length of the fruit;
and 7, stage: the length of the lesion spots accounts for 11-25% of the length of the fruit;
and 9, stage: the length of the lesion spots accounts for more than 26 percent of the length of the fruit.
Method for calculating drug efficacy
Safety investigations and effects on other organisms: after application, the influence of each treatment on crops is observed in detail before the next application, and the symptoms (dead seedlings, growth inhibition, chlorosis, deformity, withered leaves and the like) of phytotoxicity of tomato plants in the treatment areas are accurately described and recorded.
TABLE 6 field test results of efficacy of penthiopyrad and pyraclostrobin mixture for preventing and treating tomato gray mold
The safety of the tomatoes is investigated, and during the test period, the phenomenon that each treatment agent does not cause phytotoxicity to tomato stems and leaves is observed and found.
The field test results in table 6 show that, with clear water as a control, compared with single penthiopyrad and pyraclostrobin, the penthiopyrad and pyraclostrobin mixed preparation has a good control effect on tomato gray mold, and when the mass ratio of penthiopyrad to pyraclostrobin is 1:1.5, the control effect on tomato gray mold is optimal. The combination of the two not only reduces the dosage and the cost of the drug, but also is safe to the growth of the tomatoes.
In conclusion, the penthiopyrad-containing bactericidal composition has a good control effect on gray mold and powdery mildew of crops, and is safe for target crops. The compound preparation not only improves the control effect, but also reduces the dosage and the cost, and is an ideal medicament for controlling gray mold and powdery mildew. Therefore, the invention and the popularization of the compound preparation have very important significance to the society.
The present invention has been described in detail above. It will be apparent to those skilled in the art that the invention can be practiced within a wide range of equivalent parameters, concentrations, and conditions without departing from the spirit and scope of the invention and without undue experimentation. While the invention has been described with reference to specific examples, it will be appreciated that the invention may be further modified. In general, this application is intended to cover any variations, uses, or adaptations of the invention following, in general, the principles of the invention and including such departures from the present disclosure as come within known or customary practice within the art to which the invention pertains. The use of some of the essential features is made possible within the scope of the accompanying claims.
Claims (10)
1. A compound agricultural bactericidal composition is characterized in that: it consists of an active component A and an active component B;
the active component A is penthiopyrad;
the active component B is pyraclostrobin or bupirimate.
2. The compound agricultural bactericidal composition as set forth in claim 1, characterized in that: the mass ratio of the active component A to the active component B is 1: 0.1-1: 50.
3. the compound agricultural bactericidal composition as claimed in claim 1 or 2, which is characterized in that: the mass ratio of the active component A to the active component B is 1: 0.2-1: 5.
4. the compound agricultural bactericidal composition as set forth in any one of claims 1 to 3, which is characterized in that: the active component B is pyraclostrobin; the mass ratio of the active component A to the active component B is 1: 1.5.
5. the compound agricultural bactericidal composition as set forth in any one of claims 1 to 3, characterized in that: the active component B is bupirimate; the mass ratio of the active component A to the active component B is 1:1.
6. the application of the compound agricultural bactericidal composition as defined in any one of claims 1-5 in controlling gray mold or powdery mildew of crops.
7. A compound agricultural bactericide, which is prepared from the compound agricultural bactericidal composition of any one of claims 1 to 5 and auxiliary materials acceptable for pesticide preparations thereof, wherein the mass percentage of the compound agricultural bactericidal composition is 1 to 90 percent.
8. The compound agricultural bactericide as claimed in claim 7, which is characterized in that: the formulation of the compound agricultural bactericide is any one of a suspending agent, an aqueous emulsion, a dispersible oil suspending agent, a wettable powder, a water dispersible granule, missible oil and a microemulsion.
9. The use of the compound agricultural fungicide of claim 7 or 8 for controlling gray mold or powdery mildew of crops.
10. Use according to claim 9, characterized in that: the crops are strawberries, melons or tomatoes.
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Citations (6)
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| CN101106903A (en) * | 2005-02-04 | 2008-01-16 | 三井化学株式会社 | Plant pathogen control composition and method |
| CN101971848A (en) * | 2010-10-28 | 2011-02-16 | 江苏龙灯化学有限公司 | Bactericide composition with synergism |
| CN102870795A (en) * | 2012-10-25 | 2013-01-16 | 联保作物科技有限公司 | Sterilization composition and preparation thereof |
| CN103141496A (en) * | 2013-04-02 | 2013-06-12 | 海利尔药业集团股份有限公司 | Sterilizing composite containing pyraclostrobin and penthiopyrad |
| CN103798240A (en) * | 2013-03-20 | 2014-05-21 | 海南正业中农高科股份有限公司 | Composition containing penthiopyrad and methoxyl acrylic ester fungicidal component |
| CN104542659A (en) * | 2013-10-25 | 2015-04-29 | 中国中化股份有限公司 | Fungicidal composition containing penthiopyrad fungicide and application of fungicidal composition |
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| CN101106903A (en) * | 2005-02-04 | 2008-01-16 | 三井化学株式会社 | Plant pathogen control composition and method |
| CN101971848A (en) * | 2010-10-28 | 2011-02-16 | 江苏龙灯化学有限公司 | Bactericide composition with synergism |
| CN102870795A (en) * | 2012-10-25 | 2013-01-16 | 联保作物科技有限公司 | Sterilization composition and preparation thereof |
| CN103798240A (en) * | 2013-03-20 | 2014-05-21 | 海南正业中农高科股份有限公司 | Composition containing penthiopyrad and methoxyl acrylic ester fungicidal component |
| CN103141496A (en) * | 2013-04-02 | 2013-06-12 | 海利尔药业集团股份有限公司 | Sterilizing composite containing pyraclostrobin and penthiopyrad |
| CN104542659A (en) * | 2013-10-25 | 2015-04-29 | 中国中化股份有限公司 | Fungicidal composition containing penthiopyrad fungicide and application of fungicidal composition |
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| GOMEZ, AO等: "Protecting fungicide chemistry used in Australian strawberry production for more sustainable control of powdery mildew and leaf blotch", VIII INTERNATIONAL STRAWBERRY SYMPOSIUM, vol. 1156, pages 735 - 741 * |
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| CN114916552B (en) | 2023-10-31 |
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