CN114916233A - 泛癌症早筛预测方法 - Google Patents

泛癌症早筛预测方法 Download PDF

Info

Publication number
CN114916233A
CN114916233A CN202180005828.4A CN202180005828A CN114916233A CN 114916233 A CN114916233 A CN 114916233A CN 202180005828 A CN202180005828 A CN 202180005828A CN 114916233 A CN114916233 A CN 114916233A
Authority
CN
China
Prior art keywords
cancer
early
expression profile
data
screening
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202180005828.4A
Other languages
English (en)
Inventor
康诗婷
陈伟铭
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Beacon Biomedical Co ltd
Original Assignee
Beacon Biomedical Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Beacon Biomedical Co ltd filed Critical Beacon Biomedical Co ltd
Publication of CN114916233A publication Critical patent/CN114916233A/zh
Pending legal-status Critical Current

Links

Classifications

    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/10Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1096Processes for the isolation, preparation or purification of DNA or RNA cDNA Synthesis; Subtracted cDNA library construction, e.g. RT, RT-PCR
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B25/00ICT specially adapted for hybridisation; ICT specially adapted for gene or protein expression
    • G16B25/10Gene or protein expression profiling; Expression-ratio estimation or normalisation
    • GPHYSICS
    • G16INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR SPECIFIC APPLICATION FIELDS
    • G16BBIOINFORMATICS, i.e. INFORMATION AND COMMUNICATION TECHNOLOGY [ICT] SPECIALLY ADAPTED FOR GENETIC OR PROTEIN-RELATED DATA PROCESSING IN COMPUTATIONAL MOLECULAR BIOLOGY
    • G16B40/00ICT specially adapted for biostatistics; ICT specially adapted for bioinformatics-related machine learning or data mining, e.g. knowledge discovery or pattern finding
    • G16B40/20Supervised data analysis
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/118Prognosis of disease development
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/156Polymorphic or mutational markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/178Oligonucleotides characterized by their use miRNA, siRNA or ncRNA

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Physics & Mathematics (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biophysics (AREA)
  • General Health & Medical Sciences (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Medical Informatics (AREA)
  • General Engineering & Computer Science (AREA)
  • Analytical Chemistry (AREA)
  • Bioinformatics & Computational Biology (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
  • Data Mining & Analysis (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Biochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Evolutionary Biology (AREA)
  • Theoretical Computer Science (AREA)
  • Biomedical Technology (AREA)
  • Databases & Information Systems (AREA)
  • Bioethics (AREA)
  • Public Health (AREA)
  • Evolutionary Computation (AREA)
  • Epidemiology (AREA)
  • Hospice & Palliative Care (AREA)
  • Computer Vision & Pattern Recognition (AREA)
  • Software Systems (AREA)
  • Artificial Intelligence (AREA)
  • Oncology (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Plant Pathology (AREA)

Abstract

一种泛癌症早筛预测方法,包括以下步骤:建立癌症患者族群及健康族群的微型核糖核酸表现图谱数据库,并据此建立泛癌症早筛预测方法;接下来,将受检者的液态活检样品中的微型核糖核酸表现图谱通过泛癌症早筛预测方法进行分析,以判断受检者是否可能已罹患癌症。

Description

PCT国内申请,说明书已公开。

Claims (10)

  1. PCT国内申请,权利要求书已公开。
CN202180005828.4A 2020-12-08 2021-12-08 泛癌症早筛预测方法 Pending CN114916233A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US202063122481P 2020-12-08 2020-12-08
US63/122,481 2020-12-08
PCT/CN2021/136562 WO2022121960A1 (zh) 2020-12-08 2021-12-08 泛癌症早筛预测方法

Publications (1)

Publication Number Publication Date
CN114916233A true CN114916233A (zh) 2022-08-16

Family

ID=81848310

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202180005828.4A Pending CN114916233A (zh) 2020-12-08 2021-12-08 泛癌症早筛预测方法

Country Status (4)

Country Link
US (1) US20220180973A1 (zh)
CN (1) CN114916233A (zh)
TW (1) TWI829042B (zh)
WO (1) WO2022121960A1 (zh)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024174260A1 (zh) * 2023-02-24 2024-08-29 信标生医股份有限公司 基于液态活检的癌症早期筛检方法

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US11551043B2 (en) 2018-02-28 2023-01-10 Visiongate, Inc. Morphometric detection of malignancy associated change

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103237901A (zh) * 2010-03-01 2013-08-07 卡里斯生命科学卢森堡控股有限责任公司 用于治疗诊断的生物标志物
WO2017099414A1 (ko) * 2015-12-07 2017-06-15 엘지전자 주식회사 암 진단용 마이크로rna 바이오마커 발굴 방법 및 그 이용
CN111748633A (zh) * 2020-08-04 2020-10-09 广东省第二人民医院(广东省卫生应急医院) 一种特征miRNA表达谱组合及头颈鳞状细胞癌早期预测方法

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2016089553A1 (en) * 2014-12-03 2016-06-09 Biodesix, Inc. Early detection of hepatocellular carcinoma in high risk populations using maldi-tof mass spectrometry
CN108300784A (zh) * 2018-02-05 2018-07-20 杭州更蓝生物科技有限公司 一种用于预测牙龈癌的miRNA组合物
TWI758670B (zh) * 2018-12-24 2022-03-21 奎克生技光電股份有限公司 健康風險評估方法
CN111793692A (zh) * 2020-08-04 2020-10-20 中国科学院昆明动物研究所 一种特征miRNA表达谱组合及肺鳞癌早期预测方法

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN103237901A (zh) * 2010-03-01 2013-08-07 卡里斯生命科学卢森堡控股有限责任公司 用于治疗诊断的生物标志物
WO2017099414A1 (ko) * 2015-12-07 2017-06-15 엘지전자 주식회사 암 진단용 마이크로rna 바이오마커 발굴 방법 및 그 이용
CN111748633A (zh) * 2020-08-04 2020-10-09 广东省第二人民医院(广东省卫生应急医院) 一种特征miRNA表达谱组合及头颈鳞状细胞癌早期预测方法

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
NIKHIL CHEERLA等: "MicroRNA based Pan-Cancer Diagnosis and Treatment Recommendation", 《BMC BIOINFORMATICS》, vol. 18, no. 32, 13 January 2017 (2017-01-13), pages 1 - 11, XP021264798, DOI: 10.1186/s12859-016-1421-y *
王义: "支持向量机在医学及生物方面的应用", 《硕士学位论文》, 3 September 2007 (2007-09-03), pages 1 - 38 *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2024174260A1 (zh) * 2023-02-24 2024-08-29 信标生医股份有限公司 基于液态活检的癌症早期筛检方法

Also Published As

Publication number Publication date
TWI829042B (zh) 2024-01-11
US20220180973A1 (en) 2022-06-09
WO2022121960A1 (zh) 2022-06-16
TW202223103A (zh) 2022-06-16

Similar Documents

Publication Publication Date Title
CN102369294B (zh) 非小细胞肺癌标记物及其检测方法、试剂盒和生物芯片
CN101942502B (zh) 胰腺癌标记物及其检测方法、试剂盒和生物芯片
CN107574243B (zh) 分子标志物、内参基因及其应用、检测试剂盒以及检测模型的构建方法
CN104903468B (zh) 用于帕金森氏病的新诊断MiRNA标志物
EP3524689A1 (en) Method for predicting the prognosis of breast cancer patient
KR20170035932A (ko) 위암 진단용 microrna 바이오마커
KR101672531B1 (ko) 조기 유방암 예후 예측 진단용 유전자 마커 및 이의 용도
CN104968802B (zh) 作为诊断标志物的新miRNA
CN101988059B (zh) 胃癌检测标记物及其检测试剂盒和生物芯片
WO2020048518A1 (zh) 一组用于髓母细胞瘤分子分型的基因及其应用
CN114916233A (zh) 泛癌症早筛预测方法
CN106148538B (zh) microRNA标志物组及其在制备评价乳腺癌化疗敏感性试剂盒中的应用
CN105518154B (zh) 脑癌检测
CN106661623A (zh) 使用miRNA生物标志物相对于多发性硬化诊断视神经脊髓炎
TWI758670B (zh) 健康風險評估方法
CN111424085B (zh) tRNA来源片段在制备乳腺癌诊断试剂中的应用
CN105779580A (zh) 评估罹患结肠直肠癌风险的方法及标志物
WO2014171800A1 (ko) 조기 유방암 예후 예측 진단용 자동화 시스템
CN107299129A (zh) 循环核酸作为乳腺癌生物标志物的应用
CN115772524A (zh) 一种标志物组合及其在制备诊断甲状腺癌的试剂中的应用
CN111808966B (zh) miRNA在诊断乳腺癌患病风险的应用
WO2024174260A1 (zh) 基于液态活检的癌症早期筛检方法
TWI854510B (zh) 基於液態活檢的癌症早期篩檢方法
US20240287613A1 (en) Cancer early detection method using liquid biopsy
WO2024047914A1 (en) Analysis method, kit, and detection device for cancer diagnosis by means of microrna expression

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40075724

Country of ref document: HK