CN114903831A

CN114903831A - Polypeptide protein enzyme smearing composition

Info

Publication number: CN114903831A
Application number: CN202110183789.9A
Authority: CN
Inventors: 郭锡熔; 马骏; 徐丽玲; 樊华锋
Original assignee: Shanghai Yinhong Intelligent Medical Technology Co ltd; Shanghai Tong Ren Hospital
Current assignee: Shanghai Yinhong Intelligent Medical Technology Co ltd; Shanghai Tong Ren Hospital
Priority date: 2021-02-08
Filing date: 2021-02-08
Publication date: 2022-08-16

Abstract

The invention relates to a polypeptide protein enzyme smearing composition which is characterized by comprising the following components in percentage by weight: 0.001-0.1% of protease enzyme, 0.005-0.1% of protease glucan, 0.00005-0.0003% of nano-silver, 1.2-1.8% of moisturizing conditioner, 0.50-5.2% of solidago virgaurea extract and 92.0997-97.89395% of solvent, wherein the moisturizing conditioner comprises gherkin extract, butanediol, rice extract, chamomile extract, allantoin and saccharide isomerate. The polypeptide protease smearing composition provided by the invention combines various freckle-removing, whitening, moisturizing and antibacterial substances together, can fully exert the functions of various substances, and combines the cooling and moisturizing effects of the moisturizing regulator, so that the smearing composition has a cool feeling and is more comfortable to feel after being coated on the skin of a human body, is particularly suitable for smearing after sun or laser skin cleaning, and can relieve discomfort when the skin is in itching or inflammation caused by non-injection.

Description

Polypeptide protein enzyme smearing composition

Technical Field

The invention relates to a skin care smearing matter, in particular to a polypeptide protein enzyme smearing composition.

Background

At present, skin moistening and cleaning on the surface of skin only moistens the skin and soaks stratum corneum, and how to improve the comfort of skin of people during phototherapy by laser is never considered. If the liniment is developed to be applied on the surface of the skin, the discomfort of skin changing and metabolism can be repaired, so that the liniment is very popular, and particularly has better comfort and beauty benefits after being applied to beauty-loving groups.

Extreme climates appear occasionally in recent years, and climate change aggravates the appearance of the skin adaptability of the human body; meanwhile, as the contact substance and air pollution become more and more complicated and serious, more and more people represent the self as the so-called 'sensitive skin', and the skin care problem which is more fragile and needs to be cared for the normal skin becomes an item which is not paid attention to by beauty lovers nowadays!

Disclosure of Invention

In order to solve the above problems, the present invention provides a polypeptide protease application composition to improve the comfort of application while protecting skin.

In order to achieve the above object, the present invention provides a polypeptide-proteinase application composition, which is characterized by comprising the following components by weight: 0.001-0.1% of protease enzyme, 0.005-0.1% of protease glucan, 0.00005-0.0003% of nano-silver, 1.2-1.8% of moisture-preserving modifier, 0.50-5.2% of solidago virgaurea extract and 92.0997-97.89395% of solvent, wherein the moisture-preserving modifier comprises gherkin extract, butanediol, rice extract, chamomile extract, allantoin and saccharide isomerate.

The polypeptide protease smearing composition provided by the invention combines various freckle removing, whitening, moisturizing and antibacterial substances together, can fully play the functions of various substances, is combined with the cooling and moisturizing effects of the moisturizing regulator, has a cool feeling and is more comfortable to feel after being coated on the skin of a human body, is particularly suitable for being coated after sun or laser skin cleaning, and can relieve discomfort when the skin is in pruritus or inflammation caused by non-injection.

Detailed Description

The polypeptide protein enzyme smearing composition comprises the following components in percentage by weight: 0.001-0.1% of protease enzyme, 0.005-0.1% of protease glucan, 0.00005-0.0003% of nano-silver, 1.2-1.8% of moisturizing regulator, 0.50-5.2% of solidago virgaurea extract, 92.0997-97.89395% of solvent, 0.3-0.5% of preservative and 0.10-0.20% of spice. The moisturizing conditioner comprises gherkin extract, butylene glycol, rice extract, chamomile extract, allantoin, and saccharide isomers.

The protease enzyme is used as a protein and polypeptide hydrolysis catalytic substance, can lighten pigmentation and has the effects of removing spots and beautifying.

The protease glucan is a skin conditioner, effectively relieves the skin which is itchy and has heat discomfort after being dried in the sun, strengthens the self-repairing and whitening capability of the skin, effectively inhibits the generation of melanin, lightens color spots, and reappears that the skin is bright white, tender and smooth.

The nano silver not only can make active substances in the smearing composition fully play a role, but also can play an antibacterial role by virtue of the advantages of the spectral antibacterial property of the nano particles, the particle size of the nano silver and the like.

The moisturizing regulator mainly has the effects of moistening and moisturizing, makes the skin more comfortable after contacting, has a cool feeling and can also relieve pain. The moisture-keeping regulator comprises cucumber extract, butanediol, rice extract, chamomile extract, allantoin and saccharide isomer, and the optimal weight ratio of the components is 6:2:10:10:3: 3. The Cucumis sativus extract is rich in nutrients such as minerals, amino acids, glycoprotein, and tannin which are easily absorbed by human body, has effects of softening, refreshing, astringing and keeping moisture, and has effects of clearing away heat and toxic materials, promoting blood circulation, whitening skin, reducing wrinkle and enhancing skin immunity. The butanediol is one of the polyhydric alcohols, and because the butanediol is a micromolecular moisturizing component, the water grabbing proportion is small, and the butanediol also has a certain antibacterial effect. The safety of butylene glycol was confirmed and the test showed that, when the intermittent application was made to the human body, the application was performed every other day for 16 days, and no irritating inflammation was observed in all 200 persons who participated in the test. The rice extract can promote skin collagen regeneration, enhance cell basal layer cell activity, maintain skin elasticity and compactness, increase skin water retention, and has anti-allergy and protective effects. The chamomile flower extract contains various effective components such as volatile oil, choline, stachydrine, amino acid, flavonoid, vitamin B1, chrysanthemum lactone, chrysanthenone, chrysanthemumol and the like, can balance oil secretion, whiten skin and has the effects of inhibiting and sterilizing certain skin pathogenic fungi. Allantoin is an amphoteric compound, can combine with multiple substances to form double salt, has effects of protecting from light, sterilizing, relieving pain, resisting oxidation, and keeping skin moisture, moistening and softening. The composition containing allantoin has tissue protecting, hydrophilic, water absorbing, and moisture diffusion preventing effects. The saccharide isomerate is also called a natural humectant extracted from a natural plant saccharide complex, is similar to a carbohydrate complex in a human body, has good skin-friendly performance, is combined with free amino acid groups of lysine on keratin in cells of a horny layer to assist the keratin of the horny layer to combine with water, and cannot be easily washed away, so that a lasting moisturizing effect is achieved.

Solidago virgaurea is widely applied to treating tuberculosis, diabetes, gout, haemorrhoids, internal bleeding, asthma and arthritis in Europe and also used for treating inflammation of oral cavity and throat in folks, mainly contains a plurality of chemical components such as flavonoids, saponins, diterpenes, volatile oil, phenylpropionic acid, polysaccharide, trace elements and the like, and has the pharmacological effects of resisting inflammation, resisting bacteria, promoting urination, resisting tumors and the like, wherein the saponins contain a rutin which is a polyphenol substance and a vitamin medicament, and the most prominent effects of the solidago virgaurea is anti-edema and has the effects of reducing abnormal permeability and fragility of blood vessels and keeping and restoring the normal elasticity of the blood vessels. The solidago virgaurea extract is extracted from the overground part of solidago virgaurea, contains isoquercitin, rutin, flavone and other components, and can be used for astringing skin pores and wound healing and improving the health state of skin.

The preservative can prevent the polypeptide protease coating composition from deteriorating and prolong the shelf life, and comprises chlorphenesin and methyl benzoate. The perfume can improve the smell of the external application composition, and make it fresh and pleasant.

The solvent may be pure water or liquid with disinfection and sterilization functions, such as protease-nano silver complex disclosed in Chinese patent CN201410136155.8, which is prepared by combining protease and nano silver, and after 17 hours, the light absorption value at 250-300 nm wavelength and 450 nm wavelength is reduced. The concentration of the nano silver is 0.0125ppm to less than 3 ppm. The concentration of protease is 10ppm-500 ppm. The complex can achieve good antibacterial effect with a small dosage. The invention adopts the protease-nano silver complex as the solvent, has good skin beautifying, moisturizing and cooling effects and also has an antibacterial effect.

As a preferred embodiment of the present invention, the polypeptide-protein enzyme spread composition comprises the following components by weight percentage: 0.05% of protease enzyme, 0.05% of protease glucan, 0.0002% of nano-silver, 0.3% of gherkin extract, 0.1% of butanediol, 0.5% of rice extract, 0.5% of chamomile extract, 0.15% of allantoin, 0.15% of saccharide isomer, 0.80% of solidago virgaurea extract, preservative comprising 0.25% of chlorphenesin and 0.18% of methyl benzoate, 0.1% of spice and 96.8698% of purified water. The preparation method comprises weighing the above materials respectively, mixing them together, and stirring.

The polypeptide protease smearing composition provided by the invention combines various freckle-removing, whitening, moisturizing and antibacterial substances together, can fully exert the functions of various substances, and combines the cooling and moisturizing effects of the moisturizing regulator, so that the smearing composition has a cool feeling and is more comfortable to feel after being coated on the skin of a human body, is particularly suitable for smearing after sun or laser skin cleaning, and can relieve discomfort when the skin is in itching or inflammation caused by non-injection. The invention has simple manufacture and obvious effect of increasing the feeling of comfort.

Claims

1. The polypeptide-protein enzyme smearing composition is characterized by comprising the following components in percentage by weight: 0.001-0.1% of protease enzyme, 0.005-0.1% of protease glucan, 0.00005-0.0003% of nano-silver, 1.2-1.8% of moisturizing conditioner, 0.50-5.2% of solidago virgaurea extract and 92.0997-97.89395% of solvent, wherein the moisturizing conditioner comprises gherkin extract, butanediol, rice extract, chamomile extract, allantoin and saccharide isomerate.

2. The composition according to claim 1, wherein the solvent is a complex of protease and nanosilver at 50 ℃, and the absorbance at 250 nm to 300 nm and 450 nm decreases after 17 hours.

3. The polypeptide ferment spread composition of claim 1, wherein the solvent is purified water.

4. The Pepsin spread composition of claim 2 or 3, further comprising 0.3% to 0.5% by weight of the Pepsin spread composition of a preservative and 0.10% to 0.20% by weight of a perfume.

5. The polypeptide protease spread composition of claim 4, wherein the moisturizing conditioner comprises medium cucumber extract, butylene glycol, rice extract, chamomile extract, allantoin, and saccharide isomers in a weight ratio of 6:2:10:10:3: 3.