CN114901281A - 与2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合疗法 - Google Patents

与2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合疗法 Download PDF

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CN114901281A
CN114901281A CN202080091256.1A CN202080091256A CN114901281A CN 114901281 A CN114901281 A CN 114901281A CN 202080091256 A CN202080091256 A CN 202080091256A CN 114901281 A CN114901281 A CN 114901281A
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compound
interleukin
effective amount
patient
therapeutically effective
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T·J·布赫霍尔茨
范金红
D·W·皮尔斯
M·普德纳德
姚俊文
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Celgene Corp
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Celgene Corp
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    • A61K31/045—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates
    • A61K31/047—Hydroxy compounds, e.g. alcohols; Salts thereof, e.g. alcoholates having two or more hydroxy groups, e.g. sorbitol
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    • A61K31/573—Compounds containing cyclopenta[a]hydrophenanthrene ring systems; Derivatives thereof, e.g. steroids substituted in position 17 beta by a chain of two carbon atoms, e.g. pregnane or progesterone substituted in position 21, e.g. cortisone, dexamethasone, prednisone or aldosterone
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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CN202080091256.1A 2019-11-05 2020-11-04 与2-(4-氯苯基)-n-((2-(2,6-二氧代哌啶-3-基)-1-氧代异吲哚啉-5-基)甲基)-2,2-二氟乙酰胺的组合疗法 Pending CN114901281A (zh)

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US201962931040P 2019-11-05 2019-11-05
US62/931,040 2019-11-05
PCT/US2020/058789 WO2021091946A1 (en) 2019-11-05 2020-11-04 Combination therapy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide

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MX2022006133A (es) 2019-12-06 2022-06-17 Celgene Corp Procesos para preparar 2-(4-clorofenil)-n-((2-(2,6-dioxopiperidin- 3-il)-1-oxoisoindolin-5-il)metil)-2,2-difluoroacetamida.
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CL2022001190A1 (es) 2022-11-18
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US20210128545A1 (en) 2021-05-06
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IL292765A (en) 2022-07-01
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Application publication date: 20220812