KR20220110494A - 2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일) 메틸)-2,2-디플루오로아세트아미드를 사용한 조합 요법 - Google Patents

2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일) 메틸)-2,2-디플루오로아세트아미드를 사용한 조합 요법 Download PDF

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KR20220110494A
KR20220110494A KR1020227018468A KR20227018468A KR20220110494A KR 20220110494 A KR20220110494 A KR 20220110494A KR 1020227018468 A KR1020227018468 A KR 1020227018468A KR 20227018468 A KR20227018468 A KR 20227018468A KR 20220110494 A KR20220110494 A KR 20220110494A
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compound
interleukin
effective amount
therapeutically effective
certain embodiments
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토니아 제이. 부흐홀츠
진홍 판
다니엘 더블유. 피어스
마이클 푸르데나드
춘-웬 야오
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셀진 코포레이션
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    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/454—Non condensed piperidines, e.g. piperocaine containing further heterocyclic ring systems containing a five-membered ring with nitrogen as a ring hetero atom, e.g. pimozide, domperidone
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    • A61K31/59—Compounds containing 9, 10- seco- cyclopenta[a]hydrophenanthrene ring systems
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    • A61K38/19—Cytokines; Lymphokines; Interferons
    • A61K38/20—Interleukins [IL]
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07K16/244—Interleukins [IL]
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KR1020227018468A 2019-11-05 2020-11-04 2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일) 메틸)-2,2-디플루오로아세트아미드를 사용한 조합 요법 Withdrawn KR20220110494A (ko)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962931040P 2019-11-05 2019-11-05
US62/931,040 2019-11-05
PCT/US2020/058789 WO2021091946A1 (en) 2019-11-05 2020-11-04 Combination therapy with 2-(4-chlorophenyl)-n-((2-(2,6-dioxopiperidin-3-yl)-1-oxoisoindolin-5-yl) methyl)-2,2-difluoroacetamide

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KR20220110494A true KR20220110494A (ko) 2022-08-08

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KR1020227018468A Withdrawn KR20220110494A (ko) 2019-11-05 2020-11-04 2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일) 메틸)-2,2-디플루오로아세트아미드를 사용한 조합 요법

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US (1) US12090147B2 (enExample)
EP (1) EP4054578A4 (enExample)
JP (1) JP2022554346A (enExample)
KR (1) KR20220110494A (enExample)
CN (1) CN114901281A (enExample)
AU (1) AU2020379680A1 (enExample)
BR (1) BR112022008677A2 (enExample)
CA (1) CA3157196A1 (enExample)
CL (1) CL2022001190A1 (enExample)
CO (1) CO2022005861A2 (enExample)
IL (1) IL292765A (enExample)
MX (1) MX2022005371A (enExample)
PE (1) PE20221155A1 (enExample)
WO (1) WO2021091946A1 (enExample)

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IL293481A (en) 2019-12-06 2022-08-01 Celgene Corp Processes for the preparation of 2-(4-chlorophenyl)-n-((2-(2,6-dioxypyridin-3-yl)-1-oxoisoindolin-5-yl)methyl)-2,2-difluoroacetamide
WO2023129667A1 (en) 2021-12-30 2023-07-06 Biomea Fusion, Inc. Pyrazine compounds as inhibitors of flt3
EP4680597A1 (en) * 2023-03-13 2026-01-21 The Johns Hopkins University Nonsense mediated decay inhibitor compounds

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US12090147B2 (en) 2024-09-17
CO2022005861A2 (es) 2022-05-20
CN114901281A (zh) 2022-08-12
JP2022554346A (ja) 2022-12-28
US20210128545A1 (en) 2021-05-06
IL292765A (en) 2022-07-01
MX2022005371A (es) 2022-08-04
WO2021091946A1 (en) 2021-05-14
AU2020379680A1 (en) 2022-05-26
CA3157196A1 (en) 2021-05-14
CL2022001190A1 (es) 2022-11-18
EP4054578A4 (en) 2023-11-22
BR112022008677A2 (pt) 2022-07-19
PE20221155A1 (es) 2022-07-18
EP4054578A1 (en) 2022-09-14

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