CN114887014A

CN114887014A - Composition for improving gastrointestinal digestion function and preparation method thereof

Info

Publication number: CN114887014A
Application number: CN202210642415.3A
Authority: CN
Inventors: 张显
Original assignee: Luzhou Baicaotang Health Product Co ltd
Current assignee: Luzhou Baicaotang Health Product Co ltd
Priority date: 2022-06-08
Filing date: 2022-06-08
Publication date: 2022-08-12

Abstract

The invention relates to the technical field of pharmacy, in particular to a composition for improving gastrointestinal digestion function and a preparation method thereof. The composite material comprises raw materials and auxiliary materials, wherein the raw materials comprise the following components in parts by weight: 100 parts of ginseng, 100 parts of fingered citron, 100 parts of poria cocos, 100 parts of Chinese yam, 50 parts of lotus seed, 75 parts of white hyacinth bean, 50 parts of coix seed, 50 parts of fructus amomi, 50 parts of platycodon grandiflorum and 100 parts of liquorice. And then preparing the product through the steps of preparing auxiliary materials, processing raw materials and mixing and proportioning. Based on the composition and the preparation method, the functional composition capable of effectively improving dyspepsia is provided; in the determination of suitable crowds, the formula dosage of the product is accurately controlled, the whole formula is high in safety, the effect is exact, so that the suitable crowds are relatively wide, and according to the biological function, the suitable crowds are determined as follows: for those with weakness of spleen and stomach, it is not suitable for pregnant women and lactating women.

Description

Composition for improving gastrointestinal digestion function and preparation method thereof

Technical Field

The invention relates to the technical field of pharmacy, in particular to a composition for improving gastrointestinal digestion function and a preparation method thereof.

Background

In recent years, with the increase of working pressure and the acceleration of life rhythm of people, irregular diet, overfull or too greasy diet, lack of exercise and exercise, the general increase of patients or sub-healthy people with symptoms of inappetence, indigestion after eating, abdominal distension, thin stool, sallow complexion, cough weakness, limb lassitude and the like, serious harm and influence on the body health of people.

For the diseases of gastrointestinal and digestive imbalance, the traditional Chinese medicine is adopted at present to have better treatment effect, and the traditional Chinese medicine considers that: dyspepsia mostly belongs to the symptoms of inappetence, indigestion after eating, abdominal distension, thin stool, sallow complexion, cough weakness, limb lassitude and the like caused by spleen deficiency and excessive dampness, spleen and stomach qi deficiency and dysfunction of receiving, transporting and transforming. For example, the commonly used oral liquid of agastache for restoring vital energy comprises the following main components: patchouli oil, perilla leaf oil, radix Angelicae Dahuricae, rhizoma Atractylodis, cortex Magnolia officinalis, rhizoma Pinelliae, Poria, pericarpium Citri Tangerinae, pericarpium Arecae, and Glycyrrhrizae radix extract, and can be used for treating abdominal distention and pain, emesis, and diarrhea; the classic spleen-invigorating pill (Zhengzhi quanlong) is prepared from Atractylodis rhizoma, radix aucklandiae, Coptidis rhizoma, Glycyrrhrizae radix, Poria, Ginseng radix, Massa Medicata Fermentata, pericarpium Citri Tangerinae, fructus Amomi, fructus Hordei Germinatus preparata, fructus crataegi, rhizoma Dioscoreae, and semen Myristicae, and can be used for invigorating spleen, regulating stomach function, resolving food stagnation, and relieving diarrhea.

However, the gastrointestinal tract belongs to smooth muscle, the medicine treatment time is long, the medicine is difficult to radically cure, and the gastrointestinal digestion function of the functional food is continuously improved after the functional food is taken for a long time, so that the gastrointestinal digestion function is recovered. In view of the fact that sub-health people with dyspepsia are common (children and old people are more), no novel functional food with good effect can improve symptoms of dyspepsia in the market at present.

Disclosure of Invention

The invention aims to provide a composition for improving gastrointestinal digestion function and a preparation method thereof, and aims to provide a functional composition capable of effectively improving dyspepsia.

The invention is realized by the following technical scheme: the composition for improving the gastrointestinal digestion function comprises raw materials and auxiliary materials, wherein the raw materials comprise the following components in parts by weight: 85-115 parts of ginseng, 85-115 parts of fingered citron, 85-115 parts of poria cocos, 85-115 parts of Chinese yam, 40-60 parts of lotus seed, 60-90 parts of white hyacinth bean, 35-55 parts of coix seed, 40-65 parts of fructus amomi, 35-55 parts of platycodon grandiflorum and 90-110 parts of liquorice.

Further, the raw materials comprise: 95-105 parts of ginseng, 90-110 parts of fingered citron, 96-110 parts of poria cocos, 90-105 parts of Chinese yam, 45-55 parts of lotus seed, 70-80 parts of white hyacinth bean, 45-53 parts of coix seed, 46-55 parts of fructus amomi, 40-55 parts of platycodon grandiflorum and 95-105 parts of liquorice.

Still further, the feedstock comprises: 100 parts of ginseng, 100 parts of fingered citron, 100 parts of poria cocos, 100 parts of Chinese yam, 50 parts of lotus seed, 75 parts of white hyacinth bean, 50 parts of coix seed, 50 parts of fructus amomi, 50 parts of platycodon grandiflorum and 100 parts of liquorice. It should be noted that, in the prior art, because the gastrointestinal tract belongs to smooth muscle, the medicine has long treatment time and is difficult to cure radically, and the functional food can improve the gastrointestinal digestion function continuously after being taken for a long time, thereby achieving the recovery of the gastrointestinal digestion function. In view of the fact that sub-health people with dyspepsia are common (children and old people are more), no novel functional food with good effect can improve symptoms of dyspepsia in the market at present. In view of the above circumstances, the applicant proposes a composition for improving gastrointestinal digestion function, which is specifically realized by fingered citron in a formula, wherein the fingered citron has the following functions: soothing liver and regulating qi, harmonizing stomach and relieving pain, drying dampness and resolving phlegm, it is commonly used for qi stagnation of liver and stomach, distending pain of chest and hypochondrium, fullness and distention in stomach, anorexia and vomiting, cough and excessive phlegm. In the aspect of determining suitable crowds, the formula dosage of the product is accurately controlled, the whole formula is high in safety, and the effect is definite, so that the suitable crowds are relatively wide.

Further, the raw materials account for 10% -15%, the auxiliary materials account for 85% -90%, and the auxiliary materials comprise, by weight, 700 parts of coarse cereals, 250 parts of sugar alcohol and 200 parts of chitosan, wherein the coarse cereals account for 500-. The application of the chitosan is one of the auxiliary materials, and related experiments show that the auxiliary material can obviously prolong the retention time in the stomach of the medicine and improve the bioavailability of the medicine, and aims at providing the chitosan which is a traditional Chinese medicine compound functional food with the characteristic of 'medicine-assistant-in-one'.

Further, the auxiliary materials comprise, by weight, 600 parts of coarse cereals, 200 parts of sugar alcohols and 150 parts of chitosan.

Further, the coarse cereals are selected from one or more of walnut kernels, peanuts, soybeans, sticky rice, corns and black sesame.

Further, the sugar alcohol is selected from one or more of erythritol, maltitol, sorbitol, xylitol and lactitol.

Preferably, the sugar alcohol is xylitol.

A preparation method of a composition for improving gastrointestinal digestion function comprises the following steps: step 1, preparing auxiliary materials, namely weighing coarse cereals, sugar alcohol and chitosan according to the formula dosage of the auxiliary materials, cooking, placing in a mixer, and mixing until the color and texture of the materials are uniform to obtain mixed auxiliary materials; step 2, processing the raw materials, weighing the raw materials according to the formula amount, cooking, putting the raw materials into a grinder for grinding, and sieving to obtain mixed fine powder, wherein the size of the mixed fine powder is controlled to be 80-100 meshes; and 3, mixing and proportioning, namely mixing and proportioning the mixed auxiliary materials obtained in the step 1 and the mixed fine powder obtained in the step 2 according to the formula dosage, and then subpackaging and sealing. Based on the above preparation method, a composition for improving gastrointestinal digestion function can be prepared.

Compared with the prior art, the invention has the following advantages and beneficial effects:

1. after the composition is taken for a long time, the gastrointestinal digestion function is continuously improved, the gastrointestinal digestion function is recovered, and a functional composition capable of effectively improving dyspepsia is provided;

2. in the determination of suitable crowds, the formula dosage of the product is accurately controlled, the whole formula is high in safety, the effect is exact, so that the suitable crowds are relatively wide, and according to the biological function, the suitable crowds are determined as follows: for patients with spleen-stomach weakness, the product is not suitable for pregnant women and lactating women;

3. the preparation method of the invention is scientific, reasonable, simple and feasible, the raw materials are from natural edible traditional Chinese medicines, and the health-care tea is nontoxic, harmless and free of side effects, and integrates medicinal and edible homology and health-preserving and treatment into a whole.

Drawings

The accompanying drawings, which are included to provide a further understanding of the embodiments of the invention and are incorporated in and constitute a part of this application, illustrate embodiment(s) of the invention and together with the description serve to explain the principles of the invention. In the drawings:

FIG. 1 is a schematic flow chart of the preparation method of the present invention.

Detailed Description

In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail below with reference to examples and accompanying drawings, and the exemplary embodiments and descriptions thereof are only used for explaining the present invention and are not meant to limit the present invention. It should be noted that the present invention is in practical development and use.

The compositions provided in the examples of the present application to improve the digestive function of the intestines and stomach are specifically described below.

The application provides a composition for improving gastrointestinal digestion function, including raw materials and auxiliary material, by weight, the raw materials include: 85-115 parts of ginseng, 85-115 parts of fingered citron, 85-115 parts of poria cocos, 85-115 parts of Chinese yam, 40-60 parts of lotus seed, 60-90 parts of white hyacinth bean, 35-55 parts of coix seed, 40-65 parts of fructus amomi, 35-55 parts of platycodon grandiflorum and 90-110 parts of liquorice.

In some embodiments, the above starting materials may include: 95-105 parts of ginseng, 90-110 parts of fingered citron, 96-110 parts of poria cocos, 90-105 parts of Chinese yam, 45-55 parts of lotus seed, 70-80 parts of white hyacinth bean, 45-53 parts of coix seed, 46-55 parts of fructus amomi, 40-55 parts of platycodon grandiflorum and 95-105 parts of liquorice.

In other embodiments, the above preparation raw materials may include: 100 parts of ginseng, 100 parts of fingered citron, 100 parts of poria cocos, 100 parts of Chinese yam, 50 parts of lotus seed, 75 parts of white hyacinth bean, 50 parts of coix seed, 50 parts of fructus amomi, 50 parts of platycodon grandiflorum and 100 parts of liquorice.

The gastrointestinal tract is smooth muscle, the medicine has long treatment time and is difficult to radically cure, and the gastrointestinal digestion function of the functional food is continuously improved after the functional food is taken for a long time, so that the gastrointestinal digestion function is recovered. In the application, the fingered citron has the functions of soothing the liver, regulating qi, harmonizing stomach, relieving pain, eliminating dampness and reducing phlegm, and is used for treating qi stagnation of liver and stomach, chest and hypochondrium distending pain, epigastric fullness, anorexia, vomiting and cough with excessive phlegm. Ginseng, radix Ginseng, being sweet, bitter and warm, has the effect of tonifying qi of brain and lung through the spleen and lung meridians; poria cocos, sweet and bland, is the essential herb for promoting diuresis, excreting dampness, invigorating spleen and promoting transportation; the Chinese yam is sweet and neutral, and has the effects of tonifying spleen and stomach and benefiting lung and kidney; the lotus seed is sweet, mild and astringent, and can tonify spleen and stomach and astringe intestines to check diarrhea; the hyacinth beans are sweet, mild and warm, and can tonify spleen and resolve dampness; coix seed, semen Coicis, sweet in taste and slightly cold in nature, has the effects of invigorating spleen and removing dampness; fructus amomi is aromatic, pungent and warm, and has the effects of resolving dampness, activating spleen, promoting qi circulation and harmonizing stomach; platycodon grandiflorum is pungent and bitter and neutral, and can promote lung qi, ventilate lung and resolve phlegm and stop cough; prepared licorice root, radix Glycyrrhizae Praeparata, as well as replenishing qi and regulating the middle warmer, moisten lung and arrest cough.

The raw materials account for 10-15%, the auxiliary materials account for 85-90%, and the auxiliary materials comprise, by weight, 700 parts of coarse cereals, 250 parts of sugar alcohol and 200 parts of chitosan, wherein the coarse cereals comprise 500-.

In some embodiments, the adjuvant includes, in parts by weight, 600 parts of coarse cereals, 200 parts of sugar alcohols, and 150 parts of chitosan.

The coarse cereals are selected from one or more of walnut kernels, peanuts, soybeans, sticky rice, corns and black sesame.

It is also noted that the sugar alcohol is selected from one or more of erythritol, maltitol, sorbitol, xylitol and lactitol.

In this embodiment, the sugar alcohol is preferably xylitol.

It should be further noted that chitosan is a natural high molecular basic polysaccharide, has the advantages of good biocompatibility, easy absorption, easy degradation and the like, and is widely applied to the fields of water treatment, metal extraction and recovery, biochemistry, biomedical engineering and the like. The auxiliary materials can effectively reduce the water activity of the powder, improve the stability of the medicament in shelf life, obviously improve the compliance of a packaging process and obviously improve the requirements of quick dissolution, good taste and the like when the powder is directly taken orally.

In addition, the present application also provides a method for preparing a composition for improving gastrointestinal digestion function, as shown in fig. 1, which may comprise the following steps: step 1, preparing auxiliary materials, namely weighing coarse cereals, sugar alcohol and chitosan according to the formula dosage of the auxiliary materials, cooking, placing in a mixer, and mixing until the color and texture of the materials are uniform to obtain mixed auxiliary materials; step 2, processing the raw materials, weighing the raw materials according to the formula amount, cooking, putting the raw materials into a grinder for grinding, and sieving to obtain mixed fine powder, wherein the size of the mixed fine powder is controlled to be 80-100 meshes; and 3, mixing and proportioning, namely mixing and proportioning the mixed auxiliary materials obtained in the step 1 and the mixed fine powder obtained in the step 2 according to the formula dosage, and then subpackaging and sealing.

In some embodiments, step 1 further comprises: and placing the mixed auxiliary materials in a granulator, spraying and granulating, drying until the moisture is less than 0.5%, sieving the granulated powder with a 100-mesh sieve to obtain a powder with the granularity of less than 75% of the total amount, and sieving with a 60-mesh sieve to obtain an auxiliary material composition, wherein the content of the undersize is more than 90% of the total amount.

The features and properties of the present application are described in further detail below with reference to examples.

Example 1:

the embodiment provides a composition for improving gastrointestinal digestion function, which comprises raw materials and auxiliary materials, wherein the raw materials comprise: the traditional Chinese medicine composition comprises, by weight, 85 parts of ginseng, 85 parts of fingered citron, 85 parts of poria cocos, 85 parts of Chinese yam, 40 parts of lotus seed, 60 parts of white hyacinth bean, 35 parts of coix seed, 40 parts of fructus amomi, 35 parts of platycodon grandiflorum and 90 parts of liquorice.

The auxiliary materials comprise: 500 parts of coarse cereals, 300 parts of sugar alcohol and 100 parts of chitosan. Wherein, the raw materials account for 10 percent of the total amount, and the auxiliary materials account for 90 percent of the total amount.

Example 2:

the embodiment provides a composition for improving gastrointestinal digestion function, which comprises raw materials and auxiliary materials, wherein the raw materials comprise: 105 parts of ginseng, 110 parts of fingered citron, 110 parts of poria cocos, 105 parts of Chinese yam, 55 parts of lotus seed, 80 parts of white hyacinth bean, 53 parts of coix seed, 55 parts of fructus amomi, 55 parts of platycodon grandiflorum and 105 parts of liquorice.

The auxiliary materials comprise: 700 parts of coarse cereals, 500 parts of sugar alcohol and 200 parts of chitosan. Wherein, the raw materials account for 15 percent of the total amount, and the auxiliary materials account for 85 percent of the total amount.

Example 3:

the embodiment provides a composition for improving gastrointestinal digestion function, which comprises raw materials and auxiliary materials, wherein the raw materials comprise: 100 parts of ginseng, 100 parts of fingered citron, 100 parts of poria cocos, 100 parts of Chinese yam, 50 parts of lotus seed, 75 parts of white hyacinth bean, 50 parts of coix seed, 50 parts of fructus amomi, 50 parts of platycodon grandiflorum and 100 parts of liquorice.

The auxiliary materials comprise: 600 parts of coarse cereals, 200 parts of sugar alcohol and 150 parts of chitosan. Wherein, the raw materials account for 12 percent of the total amount, and the auxiliary materials account for 88 percent of the total amount.

The beneficial effects of the present application are demonstrated by specific pharmacodynamic experiments below,

experimental example:

in order to determine the optimal proportioning measurement of the experimental medicines, 3 proportioning groups with different dosages are set for preliminary screening, the formula proportions of the proportioning groups respectively correspond to example 1, example 2 and example 3, and in addition, a blank control group and a model control group are also arranged.

The specific experimental method comprises the following steps: 84 male KM mice are taken and randomly divided into 6 groups, including 3 administration groups with different proportions, a blank control group and a model control group, and each group contains 14 animals. The test samples and the agastache rugosus oral liquid (3.3 ml/kgBW) are respectively orally administered with 10 times of the daily dosage of a human body (7.4 g of crude drug/kgBW) according to 3 different proportions, 1 time/d, 15 days continuously, and the test water is administered to a blank group and a model control group according to the same volume. After the test sample was given for 15d, each group of mice was fasted for 16h without water deprivation. After 30min, the model control group, 4 proportioning groups and the agastache healthy energy oral liquid group are respectively administered with compound diphenoxylate (5mg/kgBW) by intragastric administration, and the blank group is administered with experimental water. After 30min of compound diphenoxylate, 4 matched groups were given with ink containing corresponding test sample (containing 5% activated carbon powder and 10% gum arabic), blank group and model control group. Giving ink 25min later, neck-breaking and killing the animal, dissecting and separating mesentery, taking out pylorus (upper end) to ileocecal part (lower end) small intestine, placing the small intestine on a tray, slightly pulling the small intestine to be in a straight line, measuring the total length of the small intestine, and calculating the ink advancing length (pylorus to ink front edge) according to the following formula:

an ink propulsion ratio (P) is an ink propulsion length (cm)/total small intestine length (cm),

the rate of advance of the ink is,

and (4) carrying out statistical analysis on the results of each proportioning group, a blank control group and a model control group by adopting SPSS12.0 software.

The experiment of the influence of different example ratios on the small intestine movement of the mice is shown in the table 1:

as can be seen from table 1 above, the ink propulsion ratio and the propulsion rate of the model control group are significantly lower than those of the blank control group, indicating that the constipation model of the mouse is established. Compared with a model control group, the mixture ratio of the embodiment of the application can obviously promote the small intestine movement, wherein the advancing rate of the mice in the embodiment 3 is obviously superior to that of the embodiments 1 and 2, so that the application has a promoting effect on the gastric emptying of the mice and an inhibiting effect on the small intestine advancing movement of normal mice and diabetic spleen-deficiency mice. The external small dose can partially resist the in vitro intestinal canal inhibition of the rabbit caused by adrenalin, so that the tension and the contraction amplitude of the intestinal canal are increased; the large dosage can inhibit intestinal canal movement and resist intestinal canal spasmodic contraction caused by barium chloride and pilocarpine. It is also found by anti-ulcerative colitis experiments that: the application can effectively prevent the colon length of mice with trinitrobenzene sulfonic acid (TNBS) colitis from being shortened, reduce the levels of TNF-a and IL-1 beta of intestinal mucosa, increase the proportion of mesenteric lymph node lymphocyte CD4+. CD25+ Foxp3+/CD4+ T cells, and increase the IL-10 secretion level of the intestinal mucosa.

The above-mentioned embodiments are intended to illustrate the objects, technical solutions and advantages of the present invention in further detail, and it should be understood that the above-mentioned embodiments are merely exemplary embodiments of the present invention, and are not intended to limit the scope of the present invention, and any modifications, equivalent substitutions, improvements and the like made within the spirit and principle of the present invention should be included in the scope of the present invention.

Claims

1. A composition for improving gastrointestinal digestive function, comprising: the composite material comprises raw materials and auxiliary materials, wherein the raw materials comprise the following components in parts by weight: 85-115 parts of ginseng, 85-115 parts of fingered citron, 85-115 parts of poria cocos, 85-115 parts of Chinese yam, 40-60 parts of lotus seed, 60-90 parts of white hyacinth bean, 35-55 parts of coix seed, 40-65 parts of fructus amomi, 35-55 parts of platycodon grandiflorum and 90-110 parts of liquorice.

2. The composition for improving gastrointestinal digestive function according to claim 1, wherein: the raw materials comprise: 95-105 parts of ginseng, 90-110 parts of fingered citron, 96-110 parts of poria cocos, 90-105 parts of Chinese yam, 45-55 parts of lotus seed, 70-80 parts of white hyacinth bean, 45-53 parts of coix seed, 46-55 parts of fructus amomi, 40-55 parts of platycodon grandiflorum and 95-105 parts of liquorice.

3. The composition for improving gastrointestinal digestive function according to claim 2, wherein: the raw materials comprise: 100 parts of ginseng, 100 parts of fingered citron, 100 parts of poria cocos, 100 parts of Chinese yam, 50 parts of lotus seed, 75 parts of white hyacinth bean, 50 parts of coix seed, 50 parts of fructus amomi, 50 parts of platycodon grandiflorum and 100 parts of liquorice.

4. A composition for improving gastrointestinal digestive function according to any one of claims 1 to 3 wherein: the raw materials account for 10-15%, the auxiliary materials account for 85-90%, and the auxiliary materials comprise, by weight, 700 parts of coarse cereals, 150 parts of sugar alcohol and 200 parts of chitosan.

5. The composition for improving gastrointestinal digestive function according to claim 4, wherein: the auxiliary materials comprise, by weight, 600 parts of coarse cereals, 200 parts of sugar alcohol and 150 parts of chitosan.

6. A composition for improving gastrointestinal digestive function according to claim 4 or 5, wherein: the coarse cereals are selected from one or more of walnut kernels, peanuts, soybeans, sticky rice, corns and black sesame.

7. A composition for improving gastrointestinal digestive function according to claim 4 or 5, wherein: the sugar alcohol is selected from one or more of erythritol, maltitol, sorbitol, xylitol and lactitol.

8. A composition for improving gastrointestinal digestive function according to claim 4 or 5, wherein: the sugar alcohol is xylitol.

9. A preparation method of a composition for improving gastrointestinal digestion function is characterized by comprising the following steps: a composition for improving gastrointestinal digestive function according to any one of claims 1 to 8, comprising the steps of:

step 1, preparing auxiliary materials, namely weighing coarse cereals, sugar alcohol and chitosan according to the formula dosage of the auxiliary materials, cooking, placing in a mixer, and mixing until the color and texture of the materials are uniform to obtain mixed auxiliary materials;

step 2, processing the raw materials, weighing the raw materials according to the formula amount, cooking, putting the raw materials into a grinder for grinding, and sieving to obtain mixed fine powder, wherein the particle size of the mixed fine powder is controlled to be 80-100 meshes;

and 3, mixing and proportioning, namely mixing and proportioning the mixed auxiliary materials obtained in the step 1 and the mixed fine powder obtained in the step 2 according to the formula dosage, and then subpackaging and sealing.