CN114886116B - Composition for conditioning health of women of child bearing age, preparation method and beverage thereof and application - Google Patents
Composition for conditioning health of women of child bearing age, preparation method and beverage thereof and application Download PDFInfo
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- CN114886116B CN114886116B CN202210273327.0A CN202210273327A CN114886116B CN 114886116 B CN114886116 B CN 114886116B CN 202210273327 A CN202210273327 A CN 202210273327A CN 114886116 B CN114886116 B CN 114886116B
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Landscapes
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- Non-Alcoholic Beverages (AREA)
Abstract
The invention belongs to the technical field of functional foods, and relates to a composition for conditioning health of women of childbearing age, a preparation method thereof, a beverage and application thereof; comprises the following components in parts by mass: 30-35 parts of red ginseng extract; 12-20 parts of donkey-hide gelatin peptide; 25-38.5 parts of blood peptide; 9-22.5 parts of gamma-aminobutyric acid; 5.5-10.5 parts of bird's nest peptide. The composition for conditioning the health of women of childbearing age is prepared by combining red ginseng and donkey-hide gelatin, matching with modern clinical blood peptide and bird's nest peptide, and additionally adding gamma-aminobutyric acid serving as a raw material for adjusting sleep neurotransmitter; the coordination of the raw materials for regulating qi and blood and the raw materials for improving sleep has a synergistic effect, so that a better regulating effect is realized; and simultaneously, the absorption and utilization effects are improved by adopting small molecular peptides such as donkey-hide gelatin peptide, blood peptide and the like which are easier to absorb. The composition focuses on the essence of blood deficiency of the sleep problem of women of childbearing age, mainly nourishes blood and supplements qi, and is aided with tranquillization and sleep aiding, so that the sleep problem of women of childbearing age is improved.
Description
Technical Field
The invention belongs to the technical field of functional foods, and particularly relates to a composition for conditioning health of women of childbearing age, a preparation method thereof, a beverage and application thereof.
Background
Sleep problems in women are becoming more important. The common products on the market for conditioning insomnia of women of childbearing age are mainly herbal materials with the effects of soothing nerves, relieving convulsion and nourishing heart, or functional materials with the effects of regulating neurotransmitters, such as melatonin, gamma-aminobutyric acid and the like. Such products are primarily concerned with their symptoms, not fully concerned with the nature of the female sleep problem.
Because women have qi and blood accumulated in the front of menstrual period, the women are easy to feel depressed and dysphoric; blood-sea deficiency after menstrual period, or weakness or tiredness; during pregnancy, qi and blood are needed to nourish the fetus, and blood is lost and vital essence is lost during delivery; milk secretion during lactation depletes self qi and blood and feeding infants takes care of the body; liver and kidney deficiency occurs during perimenopause. Therefore, women have the blood as the principal and often have insufficient blood. The old Chinese medicine Xu Lingyun of the Chinese academy of science considers that 'female insomnia' takes blood as the basis and qi as the standard. The primary symptom of insomnia is blood deficiency. Female qi and blood tonifying products are common, but the female qi and blood tonifying products mainly focus on improving female face qi color, and reports on female sleep problems and microcirculation improvement are not found.
Disclosure of Invention
In order to overcome the defects of the prior art, one of the purposes of the invention is to provide a composition for conditioning the health of women of childbearing age, which mainly nourishes blood and supplements qi, and is assisted by tranquillization and helps to sleep, so as to improve the sleep problem of women of childbearing age; the composition is easy to absorb, has obvious effect, can improve sleep problem of women of childbearing age, and can regulate female ischemia and menstrual period quantity.
The second purpose of the invention is to provide a preparation method of the composition for conditioning health of women of childbearing age, which is simple and safe.
The invention also aims to provide the application of the composition for conditioning the health of women of childbearing age.
The invention aims at providing a beverage for conditioning health of women of childbearing age.
One of the purposes of the invention is realized by adopting the following technical scheme:
a composition for conditioning health of women of childbearing age comprises the following components in parts by mass:
further, the average molecular weight of the donkey-hide gelatin peptide is 400-600Da; the average molecular weight of the blood peptide is 400-600Da; the average molecular weight of the bird's nest peptide is 1000-1200Da.
The second purpose of the invention is realized by adopting the following technical scheme:
a method of preparing a composition for conditioning the health of women of child bearing age comprising the steps of:
s1, weighing red ginseng extract, donkey-hide gelatin peptide, blood peptide, gamma-aminobutyric acid and bird' S nest peptide according to the formula amount;
s2, uniformly mixing the red ginseng extract, the donkey-hide gelatin peptide, the blood peptide, the gamma-aminobutyric acid and the bird' S nest peptide to obtain the composition for conditioning the health of women of childbearing age.
The preparation method of the red ginseng extract comprises the following steps:
1) Slicing Ginseng radix Rubri, adding into water, heating for micro-boiling extraction for 1-2 hr, and filtering with 150-250 mesh sieve to obtain residue and first filtrate;
2) Adding the residues into water, heating and slightly boiling for 0.5-1.5h, and filtering with 150-250 meshes to obtain a second filtrate;
3) Mixing the first filtrate and the second filtrate, heating and concentrating to obtain red ginseng extract, and spray-drying the red ginseng extract to obtain red ginseng extract.
The third purpose of the invention is realized by adopting the following technical scheme:
use of a composition for conditioning health of women of childbearing age in functional foods, cosmetics.
The fourth purpose of the invention is realized by adopting the following technical scheme:
a beverage for conditioning the health of women of childbearing age, comprising the composition for conditioning the health of women of childbearing age, wherein the content of the composition for conditioning the health of women of childbearing age is 10-80wt%.
Further, the beverage for conditioning health of women of childbearing age comprises the following components in parts by mass:
further, the preparation method of the beverage comprises the following steps: mixing the raw materials according to the formula, stirring at 65-75deg.C until the raw materials are mixed uniformly, sieving, sterilizing, and packaging to obtain the beverage for conditioning health of women of childbearing age.
Further, the beverage for conditioning health of women of childbearing age comprises the following components in parts by mass:
further, the preparation method of the beverage comprises the following steps:
1) Uniformly mixing sweetener and edible essence with 15-25% of resistant dextrin to obtain a premix;
2) Uniformly mixing 40-60% of resistant dextrin and a composition for conditioning health of women of childbearing age, adding the premix, then adding the rest of resistant dextrin, uniformly mixing, and discharging to obtain the beverage for conditioning health of women of childbearing age.
Donkey-hide gelatin is originally carried in Shen nong Ben Cao Jing, and has obvious blood-replenishing effect and is called as "Sheng Xue Sheng Yao". The donkey serum albumin and donkey collagen can promote proliferation of human bone marrow nucleated cells, enhance hematopoietic function, increase the level of hematopoietin, enhance hematopoietic function and enhance immunoregulatory function.
The Ginseng radix Rubri is dried root and rhizome of Ginseng radix of Araliaceae. Sex Wen Weigan has effects of invigorating primordial qi, recovering pulse, relieving depletion, invigorating qi and regulating blood. Ginseng (red ginseng) has sweet taste and is capable of warming and invigorating primordial qi, tonifying kidney and supporting yang. "one blood and one qi, one yin and one yang mutually assist each other". "
Compared with the prior art, the invention has the beneficial effects that:
the invention relates to a composition for conditioning health of women of childbearing age, which comprises red ginseng extract, donkey-hide gelatin peptide, blood peptide, gamma-aminobutyric acid and bird's nest peptide; the red ginseng extract adopted by the invention is an extract which is prepared from red ginseng and is rich in main active ingredients, namely ginsenoside and red ginseng acidic polysaccharide, has the functions of antioxidation, anti-aging, immunoregulation and the like, and in addition, the content of the pseudo-ginseng element in the red ginseng is reduced compared with that of the ginseng, so that the red ginseng is relatively safer. Donkey-hide gelatin can enhance hematopoiesis, increase level of hematopoietin and improve immunoregulatory function. The composition disclosed by the invention is prepared from the red ginseng extract capable of nourishing blood and tonifying qi and donkey-hide gelatin, can greatly tonify yin and blood, and achieves the effect of treating the root cause of sleep of women of childbearing age. Matching with blood replenishing good products, namely blood peptide and bird's nest peptide, and additionally matching with gamma-aminobutyric acid serving as a raw material for regulating sleep neurotransmitter; the coordination of the raw materials for regulating qi and blood and the raw materials for improving sleep has a synergistic effect, so that a better regulating effect is realized; and simultaneously, the absorption and utilization effects are improved by adopting small molecular peptides such as donkey-hide gelatin peptide, blood peptide and the like which are easier to absorb.
Furthermore, the Ming-Li Zhongcatalpa (Yizongbird) is said to be "blood and qi all important" and tonifying qi is prior to enriching blood; the yin and yang are combined and the yang is above the yin, the blood and the foot can assist qi and promote qi circulation, the qi and the foot formula can generate blood and promote blood circulation, the yin and the yang are combined and supplement each other, and the effects of nourishing yin and blood, tonifying kidney and supplementing qi are achieved. The added hematopeptide component in the composition can stimulate the differentiation of hematopoietic cells and the regulation and control of hematopoietic microenvironment after being absorbed, actively chelate free ferrous ions in vivo, finally promote the number of erythrocytes and hemoglobin in vivo, and exert the blood-replenishing effect together with donkey-hide gelatin, and blood feet and promote qi. Bird's nest is recorded in Ben Cao gang mu, and can enter lung to generate qi, enter kidney to nourish water, enter stomach to tonify spleen, and tonify without dryness. The small molecule bird's nest peptide prepared by the modern technology not only can enter lung to generate qi, but also has the functions of resisting oxidation, resisting aging and enhancing immunity. It promotes the organism's vital energy ' and makes the organism's blood, foot and qi sufficient, the four components can supplement each other, and the four components can play the role of nourishing yin, nourishing blood, tonifying kidney and invigorating qi together. Meanwhile, the traditional nourishing medicinal food is prepared into small molecular components by a modern biological enzymolysis technology, so that the bioavailability of the composition is improved. The composition of the invention has synergistic effect, and is suitable for women with qi and blood all-purpose diseases.
The composition is based on a clear Chinese medicine theory, focuses on the essence of blood deficiency of the sleep problem of women of childbearing age, mainly nourishes blood and supplements qi, and is aided with tranquillization and sleep aiding to improve the sleep problem of women of childbearing age; in addition, the composition is rich in small molecular peptide components, is easy to absorb, has obvious effect, can improve sleep problems of women of childbearing age, and can regulate female ischemia and menstrual period quantity.
The preparation method of the composition for conditioning health of women of child bearing age is simple and is suitable for mass production.
The application of the composition for conditioning the health of women of child bearing age is safe and healthy, is easy to be absorbed by human bodies, and has good application prospects in functional foods and cosmetics.
The beverage for conditioning the health of women of childbearing age has stable performance of active ingredients, is easy to be absorbed by human bodies, can improve the sleep problem of women of childbearing age after being drunk for a long time, and can simultaneously regulate the problems of ischemia and hypomenorrhea of women; and has good taste and flavor.
Detailed Description
The present invention will be further described with reference to the following specific embodiments, and it should be noted that, on the premise of no conflict, new embodiments may be formed by any combination of the embodiments or technical features described below.
In the following examples, raw materials are commercially available unless otherwise specified; wherein, donkey-hide gelatin peptide: purchased from Dongan donkey-hide gelatin company, the average molecular weight is 500Da, and the maximum molecular weight is not more than 2000Da; blood peptide: purchased from Hubei Rubang biosystems, the average molecular weight is 500Da, the maximum molecular weight is not more than 3000Da, and the protein is more than or equal to 60%; the average molecular weight of the bird's nest peptide is 1100Da, and the maximum molecular weight is not more than 6000Da; gamma-aminobutyric acid: purchased from Hua Xi biological company, the content is more than or equal to 98 percent.
Compositions for conditioning health of women of childbearing age comprise the following raw material components in parts by mass in examples 1 to 5 in Table 1:
TABLE 1
A method of preparing a composition for conditioning the health of women of child bearing age comprising the steps of:
s1, weighing red ginseng extract, donkey-hide gelatin peptide, blood peptide, gamma-aminobutyric acid and bird' S nest peptide according to the formula amount;
s2, uniformly mixing the red ginseng extract, the donkey-hide gelatin peptide, the blood peptide, the gamma-aminobutyric acid and the bird' S nest peptide to obtain the composition for conditioning the health of women of childbearing age.
Wherein, the preparation method of the red ginseng extract comprises the following steps:
1) Slicing Ginseng radix Rubri, adding into 10 times of purified water, heating for slightly boiling, extracting for 1.5 hr, filtering with 200 mesh gauze to obtain residue and first filtrate;
2) Adding the residue into 8 times of purified water, heating and slightly boiling for extraction for 1h, filtering with 200 mesh gauze to obtain second filtrate;
3) Mixing the first filtrate and the second filtrate, heating and concentrating to obtain red ginseng extract, and spray-drying the red ginseng extract to obtain red ginseng extract.
The compositions of comparative examples 1 to 5 were as follows in parts by mass:
TABLE 2
The compositions of comparative examples 1-5 were prepared in the same manner as a composition for conditioning the health of women of child bearing age of examples 1-5.
Comparative example 6
A composition for conditioning health of women of child bearing age of this comparative example differs from example 3 in that:
the average molecular weight of the donkey-hide gelatin peptide is 6000Da; the average molecular weight of the blood peptide is 8000Da; the average molecular weight of the bird's nest peptide is 10000Da.
Comparative example 7
A composition for conditioning health of women of child bearing age of this comparative example differs from example 3 in that:
the average molecular weight of the donkey-hide gelatin peptide is 500Da; the average molecular weight of the blood peptide is 500Da; the average molecular weight of the bird's nest peptide is 1100Da.
Example 6
An oral liquid for conditioning health of women of childbearing age comprises the following components in parts by mass:
the preparation method of the oral liquid comprises the following steps:
1) Preparing: putting the composition for conditioning health of women of child bearing age obtained in the example 3 into a preparation tank, adding pure water, fruit juice concentrate, edible essence, sweetener and acid regulator in the formula amount, stirring for 10min at 65 ℃, and sieving with 200 meshes to obtain a mixture;
2) And (3) sterilization: sterilizing the mixture obtained by preparation by adopting an ultra-high temperature instantaneous sterilization UHT technology for 10min for later use;
3) Washing the bottle: cleaning the inner packaging bottle by adopting an anion cleaning technology to obtain a clean inner packaging bottle;
4) And (3) filling: and (3) subpackaging the mixture sterilized in the step (2) into clean inner packaging bottles by adopting a full-automatic filling machine to obtain a finished product.
Example 7
An oral liquid for conditioning health of women of childbearing age comprises the following components in parts by mass:
the preparation method of the oral liquid comprises the following steps:
1) Preparing: putting the composition for conditioning health of women of child bearing age obtained in the example 3 into a preparation tank, adding pure water, fruit juice concentrate, edible essence, sweetener and acid regulator in the formula amount, stirring at 70 ℃ for 15min, and sieving with 200 meshes to obtain a mixture;
2) And (3) sterilization: sterilizing the mixture obtained by preparation by adopting an ultra-high temperature instantaneous sterilization UHT technology for 10min for later use;
3) Washing the bottle: cleaning the inner packaging bottle by adopting an anion cleaning technology to obtain a clean inner packaging bottle;
4) And (3) filling: and (3) subpackaging the mixture sterilized in the step (2) into clean inner packaging bottles by adopting a full-automatic filling machine to obtain a finished product.
Example 8
An oral liquid for conditioning health of women of childbearing age comprises the following components in parts by mass:
the preparation method of the oral liquid comprises the following steps:
1) Preparing: putting the composition for conditioning health of women of child bearing age obtained in the example 3 into a preparation tank, adding pure water, fruit juice concentrate, edible essence, sweetener and acid regulator in the formula amount, stirring at 75 ℃ for 10min, and sieving with 200 meshes to obtain a mixture;
2) And (3) sterilization: sterilizing the mixture obtained by preparation by adopting an ultra-high temperature instantaneous sterilization UHT technology for 10min for later use;
3) Washing the bottle: cleaning the inner packaging bottle by adopting an anion cleaning technology to obtain a clean inner packaging bottle;
4) And (3) filling: and (3) subpackaging the mixture sterilized in the step (2) into clean inner packaging bottles by adopting a full-automatic filling machine to obtain a finished product.
Example 9
The solid beverage for conditioning health of women of childbearing age comprises the following components in parts by mass:
18 parts of a composition for conditioning health of women of child bearing age;
15 parts of strawberry fruit powder;
20 parts of resistant dextrin.
The preparation method of the solid beverage comprises the following steps:
1) Weighing: taking the composition for conditioning health of women of child-bearing age described in example 3, and weighing raw materials according to the formula amount for later use;
2) Total mixing: adding 1/2 of the total amount of the resistant dextrin into a three-dimensional mixer, sequentially adding the composition for conditioning the health of women of child-bearing age, the strawberry fruit powder and the rest resistant dextrin into the mixer, mixing for 20min, and discharging for later use;
3) And (5) subpackaging: and subpackaging the materials obtained by total mixing by using a multi-row subpackaging machine to obtain a finished product.
Example 10
The solid beverage for conditioning health of women of childbearing age comprises the following components in parts by mass:
wherein, the sweetener adopts sucralose, and the resistant dextrin is water-soluble dietary fiber.
The preparation method of the solid beverage comprises the following steps:
1) Weighing: taking the composition for conditioning health of women of child-bearing age described in example 3, and weighing raw materials according to the formula amount for later use;
2) Premixing: dispersing and mixing the sucralose and the edible essence weighed in the step 1) for 3 times by using 1/5 of the total amount of the resistant dextrin to obtain a premix;
3) Total mixing: sequentially adding 1/2 of the total amount of the resistant dextrin, the composition for conditioning the health of women of child-bearing age, the premix, the strawberry powder and the rest resistant dextrin into a three-dimensional mixer, mixing for 20min, and discharging for later use;
4) And (5) subpackaging: and (3) subpackaging the materials obtained by the total mixing in the step (3) by using a multi-column subpackaging machine to obtain a finished product.
Example 11
The solid beverage for conditioning health of women of childbearing age comprises the following components in parts by mass:
wherein, the sweetener adopts sucralose, and the resistant dextrin is water-soluble dietary fiber.
The preparation method of the solid beverage comprises the following steps:
1) Weighing: taking the composition for conditioning health of women of child-bearing age described in example 3, and weighing raw materials according to the formula amount for later use;
2) Premixing: dispersing and mixing the sucralose and the edible essence weighed in the step 1) for 3 times by using 1/5 of the total amount of the resistant dextrin to obtain a premix;
3) Total mixing: sequentially adding 1/2 of the total amount of the resistant dextrin, the composition for conditioning the health of women of child-bearing age, the premix, the strawberry powder and the rest resistant dextrin into a three-dimensional mixer, mixing for 20min, and discharging for later use;
4) And (5) subpackaging: and (3) subpackaging the materials obtained by the total mixing in the step (3) by using a multi-column subpackaging machine to obtain a finished product.
Performance testing
1. Efficacy test for improving anemia
Randomly selecting 380-tail 2dpf wild type AB strain zebra fish in 19 pore plates, and inducing 20-tail zebra fish in each pore by phenylhydrazine to establish a zebra fish anemia model. The compositions of examples 1-5 and comparative examples 1-6 were diluted with water to a concentration of 0.29mg/mL to prepare test samples; similarly, the beverages of examples 6-11 were diluted with water to a concentration of 0.29mg/mL of the components of the composition for conditioning health of women of child bearing age to prepare test samples. The positive control group was given a concentration of 0.25mg/mL Xueshengning, and the normal control group and the model control group were simultaneously set at a capacity of 3mL per well. After the sample to be tested and phenylhydrazine are treated for 18 hours together, the zebra fish is dyed by o-dianisidine, 10 zebra fish are randomly selected from each experimental group after dyeing, photographed under a dissecting microscope, data are collected, the heart red blood cell dyeing intensity S is analyzed and counted, and the effect of the sample to be tested on improving anemia is evaluated according to the statistical significance of the heart red blood cell dyeing intensity. The results are shown in Table 3.
TABLE 3 Table 3
| Project | Intensity of heart erythrocyte staining |
| Normal control group | 9012.50±56 |
| Model control group | 2918.34±80 |
| Example 1 | 4819.69±76 |
| Example 2 | 4803.05±57 |
| Example 3 | 5465.88±62 |
| Example 4 | 5291.80±54 |
| Example 5 | 5553.76±73 |
| Example 6 | 4705.56±74 |
| Example 7 | 4741.19±80 |
| Example 8 | 5056.21±92 |
| Example 9 | 4753.04±68 |
| Example 10 | 5004.11±82 |
| Example 11 | 5119.69±76 |
| Comparative example 1 | 3518.30±80 |
| Comparative example 2 | 3423.54±75 |
| Comparative example 3 | 3608.21±56 |
| Comparative example 4 | 3312.04±82 |
| Comparative example 5 | 3218.35±68 |
| Comparative example 6 | 3613.21±63 |
As can be seen from table 3, the staining intensity of the zebra fish heart red blood cells in the model control group is significantly reduced compared with that in the normal control group, which indicates that the model establishment is successful. The average intensity of the zebra fish heart red blood cell staining of the tested group is obviously increased compared with that of the model control group. The result shows that the composition has obvious effect of improving phenylhydrazine-induced zebra fish anemia under the condition of the experimental concentration.
2. Test for improving microcirculation efficacy
Taking the compositions of examples 1-5 and comparative examples 1-6, and respectively adding water to dilute to prepare 200mL of sample solution with the mass percent concentration of 1%; diluting the oral liquid of examples 6-8 and the solid beverage of examples 9-11 with purified water to obtain a sample solution with a mass percentage concentration of 1%; the blank group was labeled with an equal amount of purified water.
85 healthy female rats were taken, 200+ -20 g of body weight was randomly divided into 17 groups, and the sample solutions and the blank solutions of the groups 1 to 11 and the groups 1 to 5 of examples were respectively used for continuous gastric lavage at a gastric lavage capacity of 0.1mL/10g for 14 days, and the auricle microcirculation of the rats was measured on the 14 th day. The rat was then anesthetized and the auricle microcirculatory blood flow (PU) was measured using a laser doppler microcirculatory instrument, and the PU differences before and after each group of experiments were compared. The test results of PU values are all continuous variables, expressed as mean.+ -. Standard deviation, using one-way analysis of variance for each set of data, and the results are shown in Table 4.
TABLE 4 Table 4
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As can be seen from table 4, there was a significant increase in the rat auricle microcirculation PU value after 14 days of intervention in the dosing group compared with the blank control group. The composition can obviously improve the local microcirculation blood flow perfusion quantity of normal rats. Has microcirculation improving effect.
3. Test for improving health problems of women of childbearing age
(1) 10 female volunteers were selected, aged between 22-49 years, with 3 or more symptoms of pale complexion, poor spirit, poor sleep quality (easy to wake, dreaminess), lower abdominal aversion to cold, and pale menstruation, abdominal pain during menstruation (including before and after), and occasional blood clot problems.
The volunteer population took the solid beverage of example 10 separately, continuously for 28 days, once a day, and 50mL each time; the administration starts from the end of the first menstrual cycle bleeding until the next menstrual cycle. After the eating period is finished, marking evaluation is carried out by filling a questionnaire, and the improvement conditions of menstrual flow, lower abdomen pain, aversion to cold, complexion, sleep and the like are carried out, so that the product improvement rate is analyzed.
The experimental results are shown in table 5; in the scoring evaluation, the score of 0 was no effect, and the better the improvement effect was, the higher the score was, and the full score was 10.
TABLE 5
| Numbering device | Less menstrual flow | Pain in lower abdomen | Aversion to cold and cold limbs | Pale complexion | Poor sleep |
| 1 | 8 | 7 | 7 | 8 | 9 |
| 2 | 9 | 7 | 8 | 6 | 7 |
| 3 | 7 | 8 | 9 | 7 | 8 |
| 4 | 8 | 6 | 7 | 8 | 7 |
| 5 | 9 | 7 | 7 | 8 | 9 |
| 6 | 7 | 6 | 9 | 8 | 9 |
| 7 | 7 | 7 | 8 | 9 | 8 |
| 8 | 8 | 6 | 7 | 8 | 7 |
| 9 | 8 | 9 | 8 | 7 | 8 |
| 10 | 9 | 6 | 7 | 9 | 7 |
(2) 60 female volunteers were selected and randomly divided into 6 groups, and aged between 22 and 49 years, and had 3 or more symptoms of pale complexion, poor spirit, poor sleep quality (easy to wake, dreaminess), chilly lower abdomen and pale menstruation, abdominal pain during menstruation (including before and after), and occasional blood clot problems. The volunteer population took the beverages of examples 6-11, respectively, for 28 days; the administration starts from the end of the first menstrual cycle bleeding until the next menstrual cycle. After the eating period is finished, comprehensive scoring evaluation is carried out by filling in a questionnaire, and average score of each group is calculated from improvement conditions of menstrual flow, lower abdomen pain, aversion to cold, complexion, sleep and the like. In the scoring evaluation, the score of 0 was no effect, and the better the symptom-improving effect was, the higher the score was, and the full score was 10.
TABLE 6
From the data in tables 5 and 6, the composition for conditioning the health of women of childbearing age provided by the invention can effectively improve the symptoms of hypomenorrhea, lower abdominal pain, aversion to cold, pale complexion, poor sleep and the like of women of childbearing age, and can improve the health problem of women of childbearing age.
The test results of the microcirculation improving efficacy test and the health problem improving test for women of childbearing age show that the invention has the effects of nourishing blood and supplementing qi and can improve the sleep problem of women of childbearing age.
The above embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, but any insubstantial changes and substitutions made by those skilled in the art on the basis of the present invention are intended to be within the scope of the present invention as claimed.
Claims (8)
1. The composition for conditioning health of women of child bearing age is characterized by comprising the following components in parts by mass:
30-35 parts of red ginseng extract;
12-20 parts of donkey-hide gelatin peptide;
25-38.5 parts of blood peptide;
9-22.5 parts of gamma-aminobutyric acid;
5.5-10.5 parts of bird's nest peptide;
the average molecular weight of the donkey-hide gelatin peptide is 400-600Da; the average molecular weight of the blood peptide is 400-600Da; the average molecular weight of the bird's nest peptide is 1000-1200Da;
the preparation method of the red ginseng extract comprises the following steps:
1) Slicing Ginseng radix Rubri, adding into water, heating for micro-boiling extraction for 1-2 hr, and filtering with 150-250 mesh sieve to obtain residue and first filtrate;
2) Adding the residues into water, heating and slightly boiling for 0.5-1.5h, and filtering with 150-250 meshes to obtain a second filtrate;
3) Mixing the first filtrate and the second filtrate, heating and concentrating to obtain red ginseng extract, and spray-drying the red ginseng extract to obtain red ginseng extract.
2. A method of preparing a composition for conditioning the health of women of child bearing age, for preparing a composition for conditioning the health of women of child bearing age according to claim 1, comprising the steps of:
s1, weighing red ginseng extract, donkey-hide gelatin peptide, blood peptide, gamma-aminobutyric acid and bird' S nest peptide according to the formula amount;
s2, uniformly mixing the red ginseng extract, the donkey-hide gelatin peptide, the blood peptide, the gamma-aminobutyric acid and the bird' S nest peptide to obtain the composition for conditioning the health of women of childbearing age. .
3. Use of the composition for conditioning the health of women of childbearing age according to claim 1, characterized in that it is used in the preparation of functional foods.
4. A beverage for conditioning the health of women of childbearing age comprising the composition for conditioning the health of women of childbearing age according to claim 1, characterized in that the content of the composition for conditioning the health of women of childbearing age is 10-80% by weight.
5. The beverage for conditioning health of women of child-bearing age according to claim 4, characterized by comprising the following components in parts by mass:
10-30 parts of a composition for conditioning health of women of childbearing age;
8-20 parts of fruit concentrated juice;
0.01-0.5 part of edible essence;
0.01-1 part of sweetener;
0.01-3 parts of acid regulator;
30-60 parts of water.
6. The beverage for conditioning the health of women of child-bearing age according to claim 5, characterized in that the method for preparing the beverage comprises the following steps: mixing the raw materials according to the formula, stirring at 65-75deg.C until the raw materials are mixed uniformly, sieving, sterilizing, and packaging to obtain the beverage for conditioning health of women of childbearing age.
7. The beverage for conditioning health of women of child-bearing age according to claim 4, characterized by comprising the following components in parts by mass:
18-35 parts of a composition for conditioning health of women of child bearing age;
0-1 part of sweetener;
0-4.5 parts of edible essence;
8-15 parts of strawberry powder;
20-34 parts of resistant dextrin. .
8. The beverage for conditioning the health of women of child-bearing age according to claim 7, characterized in that the method for preparing the beverage comprises the following steps:
1) Uniformly mixing sweetener and edible essence with 15-25% of resistant dextrin to obtain a premix;
2) Uniformly mixing 40-60% of resistant dextrin and a composition for conditioning health of women of childbearing age, adding the premix, then adding the rest of resistant dextrin, uniformly mixing, and discharging to obtain the beverage for conditioning health of women of childbearing age.
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Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050097415A (en) * | 2004-04-03 | 2005-10-07 | 학교법인 경희대학교 | Composition comprising the extract of red ginseng |
| CN1858225A (en) * | 2005-04-30 | 2006-11-08 | 邹远东 | Process for preparing bird's nest polypeptide and use |
| CN102102119A (en) * | 2010-12-03 | 2011-06-22 | 北京中生奥普寡肽技术研究所 | Bird's nest oligopeptide composition and preparation method and use thereof |
| CN106107398A (en) * | 2016-08-01 | 2016-11-16 | 广州美贝贸易有限公司 | A kind of solid beverage rich in donkey-hide gelatin peptide and preparation method thereof |
| WO2016183789A1 (en) * | 2015-05-19 | 2016-11-24 | 陈天煌 | Composition extracted from bird's nest, and food comprising composition extracted from bird's nest |
| CN106615468A (en) * | 2016-12-29 | 2017-05-10 | 广西桂人堂金花茶产业集团股份有限公司 | Golden camellia plant beverage for replenishing blood and maintaining beauty |
| CN108740863A (en) * | 2018-06-05 | 2018-11-06 | 中泰宜佳健康科技（北京）有限责任公司 | A kind of composition of blood-enrich and its preparation method and application |
| CN108967795A (en) * | 2018-07-04 | 2018-12-11 | 长春金荷药业有限公司 | A kind of deer hemepeptide solid beverage |
| CN110403116A (en) * | 2018-04-26 | 2019-11-05 | 北京诺贝肽生物工程研究中心(有限合伙) | A kind of donkey-hide gelatin peptide solid beverage and preparation method thereof |
| CN111616364A (en) * | 2020-07-03 | 2020-09-04 | 深圳市灵季文化传播有限公司 | Red ginseng and donkey-hide gelatin beverage and application thereof in health-care beverage |
| CN111802644A (en) * | 2020-07-20 | 2020-10-23 | 花姐生物科技(杭州)有限公司 | Food composition for improving sleep |
| CN112618691A (en) * | 2021-01-11 | 2021-04-09 | 益倍(武汉)健康科技有限公司 | Traditional Chinese medicine composition with qi and blood tonifying effect and preparation method and application thereof |
| CN113598377A (en) * | 2021-08-09 | 2021-11-05 | 河南磐康健康管理股份有限公司 | Composition for improving anemia, functional food thereof, preparation method and application |
| CN114010762A (en) * | 2021-11-01 | 2022-02-08 | 杭州佰倍优生物科技有限公司 | Preparation for improving anemia symptoms and preparation method thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0916578D0 (en) * | 2009-09-22 | 2009-10-28 | Malmsten Nils M | Polypeptides and uses thereof |
| CN102499376B (en) * | 2011-12-29 | 2014-08-27 | 山东东阿阿胶股份有限公司 | Active small-molecule donkey-hide gelatin mixture and preparation method and application thereof |
-
2022
- 2022-03-18 CN CN202210273327.0A patent/CN114886116B/en active Active
Patent Citations (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20050097415A (en) * | 2004-04-03 | 2005-10-07 | 학교법인 경희대학교 | Composition comprising the extract of red ginseng |
| CN1858225A (en) * | 2005-04-30 | 2006-11-08 | 邹远东 | Process for preparing bird's nest polypeptide and use |
| CN102102119A (en) * | 2010-12-03 | 2011-06-22 | 北京中生奥普寡肽技术研究所 | Bird's nest oligopeptide composition and preparation method and use thereof |
| WO2016183789A1 (en) * | 2015-05-19 | 2016-11-24 | 陈天煌 | Composition extracted from bird's nest, and food comprising composition extracted from bird's nest |
| CN106107398A (en) * | 2016-08-01 | 2016-11-16 | 广州美贝贸易有限公司 | A kind of solid beverage rich in donkey-hide gelatin peptide and preparation method thereof |
| CN106615468A (en) * | 2016-12-29 | 2017-05-10 | 广西桂人堂金花茶产业集团股份有限公司 | Golden camellia plant beverage for replenishing blood and maintaining beauty |
| CN110403116A (en) * | 2018-04-26 | 2019-11-05 | 北京诺贝肽生物工程研究中心(有限合伙) | A kind of donkey-hide gelatin peptide solid beverage and preparation method thereof |
| CN108740863A (en) * | 2018-06-05 | 2018-11-06 | 中泰宜佳健康科技（北京）有限责任公司 | A kind of composition of blood-enrich and its preparation method and application |
| CN108967795A (en) * | 2018-07-04 | 2018-12-11 | 长春金荷药业有限公司 | A kind of deer hemepeptide solid beverage |
| CN111616364A (en) * | 2020-07-03 | 2020-09-04 | 深圳市灵季文化传播有限公司 | Red ginseng and donkey-hide gelatin beverage and application thereof in health-care beverage |
| CN111802644A (en) * | 2020-07-20 | 2020-10-23 | 花姐生物科技(杭州)有限公司 | Food composition for improving sleep |
| CN112618691A (en) * | 2021-01-11 | 2021-04-09 | 益倍(武汉)健康科技有限公司 | Traditional Chinese medicine composition with qi and blood tonifying effect and preparation method and application thereof |
| CN113598377A (en) * | 2021-08-09 | 2021-11-05 | 河南磐康健康管理股份有限公司 | Composition for improving anemia, functional food thereof, preparation method and application |
| CN114010762A (en) * | 2021-11-01 | 2022-02-08 | 杭州佰倍优生物科技有限公司 | Preparation for improving anemia symptoms and preparation method thereof |
Non-Patent Citations (3)
| Title |
|---|
| "Substrate Specificity of Platypus Venom L-to-D-Peptide Isomerase";Paramjit S. Bansal 等;《THE JOURNAL OF BIOLOGICAL CHEMISTRY》;第283卷(第14期);第8969–8975页 * |
| "燕窝低聚肽制备工艺及生物学评价";高建萍 等;《生物学杂志》;第36卷(第1期);第96-99页 * |
| "血蛋白多肽对缺铁性贫血影响的研究";季云龙 等;《养生大世界》(第18期);第180-181页 * |
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