CN114867716B - 快速、高强度的化学发光二氧杂环丁烷 - Google Patents

快速、高强度的化学发光二氧杂环丁烷

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Publication number
CN114867716B
CN114867716B CN202080089331.0A CN202080089331A CN114867716B CN 114867716 B CN114867716 B CN 114867716B CN 202080089331 A CN202080089331 A CN 202080089331A CN 114867716 B CN114867716 B CN 114867716B
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CN114867716A (zh
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卡莱杜·拉希德
王国平
巴里·A·舍恩费尔纳
谢文华
雷努卡·德席尔瓦
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Beckman Coulter Inc
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Coulter International Corp
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/58—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances
    • G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D321/00—Heterocyclic compounds containing rings having two oxygen atoms as the only ring hetero atoms, not provided for by groups C07D317/00 - C07D319/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D407/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00
    • C07D407/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings
    • C07D407/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having oxygen atoms as the only ring hetero atoms, not provided for by group C07D405/00 containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D409/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms
    • C07D409/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings
    • C07D409/10—Heterocyclic compounds containing two or more hetero rings, at least one ring having sulfur atoms as the only ring hetero atoms containing two hetero rings linked by a carbon chain containing aromatic rings
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/655—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms
    • C07F9/6551—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring
    • C07F9/65512—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom having oxygen atoms, with or without sulfur, selenium, or tellurium atoms, as the only ring hetero atoms the oxygen atom being part of a four-membered ring condensed with carbocyclic rings or carbocyclic ring systems
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07F—ACYCLIC, CARBOCYCLIC OR HETEROCYCLIC COMPOUNDS CONTAINING ELEMENTS OTHER THAN CARBON, HYDROGEN, HALOGEN, OXYGEN, NITROGEN, SULFUR, SELENIUM OR TELLURIUM
    • C07F9/00—Compounds containing elements of Groups 5 or 15 of the Periodic Table
    • C07F9/02—Phosphorus compounds
    • C07F9/547—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom
    • C07F9/6558—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system
    • C07F9/65586—Heterocyclic compounds, e.g. containing phosphorus as a ring hetero atom containing at least two different or differently substituted hetero rings neither condensed among themselves nor condensed with a common carbocyclic ring or ring system at least one of the hetero rings does not contain nitrogen as ring hetero atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H15/00—Compounds containing hydrocarbon or substituted hydrocarbon radicals directly attached to hetero atoms of saccharide radicals
    • C07H15/26—Acyclic or carbocyclic radicals, substituted by hetero rings
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K11/00—Luminescent materials, e.g. electroluminescent or chemiluminescent
    • C09K11/06—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials
    • C09K11/07—Luminescent materials, e.g. electroluminescent or chemiluminescent containing organic luminescent materials having chemically-interreactive components, e.g. reactive chemiluminescent compositions
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N21/00—Investigating or analysing materials by the use of optical means, i.e. using sub-millimetre waves, infrared, visible or ultraviolet light
    • G01N21/75—Systems in which material is subjected to a chemical reaction, the progress or the result of the reaction being investigated
    • G01N21/76—Chemiluminescence; Bioluminescence
    • C—CHEMISTRY; METALLURGY
    • C09—DYES; PAINTS; POLISHES; NATURAL RESINS; ADHESIVES; COMPOSITIONS NOT OTHERWISE PROVIDED FOR; APPLICATIONS OF MATERIALS NOT OTHERWISE PROVIDED FOR
    • C09K—MATERIALS FOR MISCELLANEOUS APPLICATIONS, NOT PROVIDED FOR ELSEWHERE
    • C09K2211/00—Chemical nature of organic luminescent or tenebrescent compounds
    • C09K2211/10—Non-macromolecular compounds
    • C09K2211/1018—Heterocyclic compounds

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Immunology (AREA)
  • Physics & Mathematics (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Hematology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • General Chemical & Material Sciences (AREA)
  • Materials Engineering (AREA)
  • Cell Biology (AREA)
  • Plasma & Fusion (AREA)
  • Microbiology (AREA)
  • Genetics & Genomics (AREA)
  • Food Science & Technology (AREA)
  • Medicinal Chemistry (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Saccharide Compounds (AREA)
CN202080089331.0A 2019-10-28 2020-10-28 快速、高强度的化学发光二氧杂环丁烷 Active CN114867716B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202511472993.7A CN121293248A (zh) 2019-10-28 2020-10-28 快速、高强度的化学发光二氧杂环丁烷

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962926985P 2019-10-28 2019-10-28
US62/926,985 2019-10-28
PCT/US2020/057755 WO2021086977A1 (en) 2019-10-28 2020-10-28 Rapid, high-intensity chemiluminescent dioxetanes

Related Child Applications (1)

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CN114867716B true CN114867716B (zh) 2025-11-07

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US (1) US20220390459A1 (https=)
EP (1) EP4051670A1 (https=)
JP (2) JP7804573B2 (https=)
CN (2) CN114867716B (https=)
WO (1) WO2021086977A1 (https=)

Families Citing this family (9)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN113861160B (zh) * 2021-10-26 2023-06-09 南京工业大学 一种一氧化碳气体检测化学发光探针、制备方法及其应用
JP2023110666A (ja) 2022-01-28 2023-08-09 シスメックス株式会社 化合物またはその塩、組成物、化学発光方法、化学発光シグナル測定方法、試薬、試薬キットおよび被検物質測定方法
EP4551659A1 (en) 2022-07-05 2025-05-14 Beckman Coulter, Inc. Improved assay compositions and methods
JP2025531952A (ja) 2022-07-29 2025-09-26 ベックマン コールター， インコーポレイテッド アルカリホスファターゼの検出のための化学発光試薬
WO2024036295A1 (en) 2022-08-12 2024-02-15 Beckman Coulter, Inc. Cross-reference to related applications
CN115819416B (zh) * 2022-11-29 2024-06-25 遵义医科大学 一种用于检测和区分的多模态化学发光分子及其应用
WO2025155701A1 (en) * 2024-01-16 2025-07-24 Beckman Coulter, Inc. Automated clinical analyzer with alternative substrate and method of use
WO2025155731A1 (en) * 2024-01-16 2025-07-24 Beckman Coulter, Inc. Alternative substrate pack for automated clinical analyzer and methods of use
WO2025160017A1 (en) * 2024-01-26 2025-07-31 Beckman Coulter, Inc. Assay methods using chemiluminescent dioxetane compounds

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603868A (en) * 1992-10-30 1997-02-18 Abbott Laboratories Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes
CN108884386A (zh) * 2016-01-26 2018-11-23 特拉维夫大学拉玛特有限公司 用于诊断和体内成像的化学发光探针

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5004565A (en) 1986-07-17 1991-04-02 The Board Of Governors Of Wayne State University Method and compositions providing enhanced chemiluminescence from 1,2-dioxetanes
US4962192A (en) 1986-07-17 1990-10-09 Board Of Governors Of Wayne State University Chemiluminescent 1,2-dioxetane compounds
US5538847A (en) * 1989-07-17 1996-07-23 Tropix, Inc. Chemiluminescent 1,2-dioxetanes
US5773628A (en) 1994-11-14 1998-06-30 Tropix, Inc. 1,2-dioxetane compounds with haloalkoxy groups, methods preparation and use
JPH08245615A (ja) * 1995-03-11 1996-09-24 Masakatsu Matsumoto １，２−ジオキセタン誘導体
ATE213497T1 (de) * 1995-06-20 2002-03-15 Lumigen Inc Verfahren zur herstellung von 1,2- dioxetanverbindungen und mit schwefel substituierte 1,2-dioxetane als zwischenverbindungen
FR2886292B1 (fr) * 2005-05-27 2009-10-16 Quidd Soc Par Actions Simplifiee Biomarqueur a emission luminescente
WO2012006351A1 (en) * 2010-07-08 2012-01-12 Life Technologies Corporation In situ chemiluminescent substrates and assays
JP2014516947A (ja) * 2011-05-03 2014-07-17 ライフ テクノロジーズ コーポレーション フラッシュ・グロー型の１，２−ジオキセタン
US11241507B2 (en) 2017-05-24 2022-02-08 Ramot At Tel-Aviv University Ltd. Near-infrared chemiluminescent probes for in-vivo imaging

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5603868A (en) * 1992-10-30 1997-02-18 Abbott Laboratories Chemiluminescent electron-rich aryl-substituted 1,2-dioxetanes
CN108884386A (zh) * 2016-01-26 2018-11-23 特拉维夫大学拉玛特有限公司 用于诊断和体内成像的化学发光探针

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
"CAS登记号160081-62-9，124951-96-8，121445-46-3";美国化学会;STN Registry数据库;19950112;第1-3页 *
"Light emission enhancement by supramolecular complexation of chemiluminescence probes designed for bioimaging";Samer Gnaim etal.;《Chemical Science》;20190116;第10卷;第2947-2948页 *
"Rapid chemiexcitation of phenoxy-dioxetane luminophores yields ultrasensitive chemiluminescence assays";Nir Hananya etal.;《Chemical Science》;20181119;第10卷;第1382、1384页 *

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JP7804573B2 (ja) 2026-01-22
US20220390459A1 (en) 2022-12-08
JP2025176001A (ja) 2025-12-03
WO2021086977A1 (en) 2021-05-06
EP4051670A1 (en) 2022-09-07
JP2022553424A (ja) 2022-12-22
CN114867716A (zh) 2022-08-05
CN121293248A (zh) 2026-01-09

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