CN114848770A

CN114848770A - Traditional Chinese medicine composition for treating rehabilitation of tumor patients after radiotherapy and chemotherapy as well as preparation method and application thereof

Info

Publication number: CN114848770A
Application number: CN202210747071.2A
Authority: CN
Inventors: 姚建华
Original assignee: Shanghai Yinli Biotechnology Co ltd
Current assignee: Shanghai Yinli Biotechnology Co ltd
Priority date: 2022-06-28
Filing date: 2022-06-28
Publication date: 2022-08-05

Abstract

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating rehabilitation of tumor patients after radiotherapy and chemotherapy, and a preparation method and application thereof, wherein the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 10 parts of astragalus, 10 parts of codonopsis pilosula, 6 parts of angelica sinensis, 6 parts of fingered citron, 6 parts of poria cocos, 6 parts of fructus alpiniae oxyphyllae, 3 parts of American ginseng, 3 parts of radix pseudostellariae, 3 parts of schisandra chinensis, 3 parts of wolfberry fruit and 2 parts of chrysanthemum. The invention also comprises the application of the traditional Chinese medicine composition in preparing the medicine for treating the rehabilitation of tumor patients after radiotherapy and chemotherapy. Its advantages are: the traditional Chinese medicine composition is prepared by preferably selecting the raw materials and the weight parts of the raw materials, has no toxic or side effect, meets the compatibility of monarch, minister, assistant and guide, and has the effects of tonifying qi and blood, strengthening spleen, calming heart, promoting the secretion of saliva or body fluid, clearing away the lung-heat, clearing away heat and toxic materials.

Description

Traditional Chinese medicine composition for treating rehabilitation of tumor patients after radiotherapy and chemotherapy as well as preparation method and application thereof

Technical Field

The invention relates to the technical field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating rehabilitation of tumor patients after radiotherapy and chemotherapy, and a preparation method and application thereof.

Background

Along with the continuous improvement of living conditions, the continuous enrichment of material conditions, the continuous acceleration of life rhythm, the urbanization and the modernization bring rich material living conditions to people, and simultaneously, the pressure of strengthening life to people is continuously increased, and the 'time' becomes more and more valuable. All people get up "fast", and modern people become "vexation", "depression" and get up because of various pressures unconsciously, and the communication among friends, colleagues, the old and the country, even couples and wives becomes less and less, however, various diseases can be brought to the home slowly, and even more and more patients with tumors and cancers become younger and more. At the current medical level of the world, most patients with the tumor disease in the middle and late stages can only be treated by means of operation or radiotherapy and chemotherapy. However, the radiotherapy and chemotherapy has great damage to human bodies, influences the physique of patients, has poor prognosis and not very ideal effect, and although the 'life' is temporarily kept, the sequelae caused by the radiotherapy and chemotherapy are bitter and unappealing to pain. Most of the existing antitumor drugs in western medicine have great toxic and side effects and also have strong killing effect on normal cell tissues. Some patients and old patients cannot tolerate the treatment of western medicines due to extreme weakness.

The traditional Chinese medicine considers that: the local and whole body of the human body are unified in terms of dialectics, and pathological changes in a certain local area of the human body are usually related to the abundance or insufficiency of the viscera, qi and blood, and yin and yang of the whole body. Because the mutual connection and influence of the viscera, tissues and organs in physiology and pathology determine that the tumor patients after diagnosis, treatment or radiotherapy and chemotherapy can recover the physiological activities of the viscera and the meridians of the patients by taking the proper traditional Chinese medicine formula and using the strength of the traditional Chinese medicine formula, so that the coordination of qi, blood and yin and yang reaches new balance.

Chinese patent application CN201410371331.6 discloses a traditional Chinese medicine composition for rehabilitation of tumor patients after radiotherapy and chemotherapy, which comprises raw material medicines of astragalus, angelica, codonopsis pilosula, donkey-hide gelatin, prepared rehmannia root, rhizoma polygonati, adenophora tetraphylla, radix glehniae, cornus officinalis, caulis spatholobi, radix ophiopogonis, rhizoma dioscoreae, rhizoma atractylodis macrocephalae, honey-fried licorice root and the like, has the effects of tonifying qi and soothing nerves, nourishing spleen and tonifying kidney, tonifying qi and blood, treating both symptoms and root causes, has obvious drug effect and can balance human immunity. The medicine has good use effect, and can effectively relieve gastrointestinal discomfort and other symptoms caused by chemotherapy and radiotherapy. The traditional Chinese medicine composition has the effects of strengthening spleen and stomach, benefiting qi and nourishing blood, and can effectively treat gastrointestinal discomfort, deficiency of qi and blood, low immunity and the like caused by radiotherapy and chemotherapy of tumor patients.

The Chinese patent application: CN202010989445.2 discloses a pharmaceutical formulation for enhancing resistance and immunity and its preparation process, which comprises astragalus root, American ginseng, schisandra fruit, pilose asiabell root, chrysanthemum flower, pseudostellaria root, poria cocos wolf. The radix pseudostellariae has the function of enhancing the immunity and the resistance, promoting the blood circulation and enhancing the physique, wherein the two components of the radix astragali and the radix codonopsitis both enter lung channels in the traditional Chinese medicine and pharmacology and have the function of tonifying qi, the two medicines have the functions of tonifying spleen and lung, tonifying qi, promoting the production of body fluid, tonifying qi, generating blood and the like, meanwhile, the radix pseudostellariae has the function of enhancing the immunity function, after the medicines are taken, the radix astragali and the radix codonopsitis promote the blood circulation so that the body can better absorb the medicines, and meanwhile, the radix Panacis Quinquefolii and the fructus schizandrae can excite nerves and resist fatigue, so that the functions of the human body are effectively adjusted and improved. The chrysanthemum plays roles in dilating coronary artery, increasing coronary blood flow and improving myocardial oxygen consumption, and can further improve the blood circulation of the body, so that the drug effect can be better played along with the accelerated flow of blood.

However, the inventor finds that the traditional Chinese medicine formula (comprising the traditional Chinese medicine formula of the two patents) in the prior art has the defects of more medicine taste and complicated preparation method or low curative effect, and based on the defects, the inventor summarizes working experience for many years and further optimizes the traditional Chinese medicine formula on the basis of previous work.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine composition for treating rehabilitation of tumor patients after radiotherapy and chemotherapy, and a preparation method and application thereof, aiming at the defects of the prior art.

In order to realize the purpose, the invention adopts the technical scheme that:

in a first aspect, the invention provides a traditional Chinese medicine composition for treating rehabilitation of tumor patients after radiotherapy and chemotherapy, which comprises the following raw material medicines in parts by weight: 5-15 parts of astragalus membranaceus, 5-15 parts of codonopsis pilosula, 3-9 parts of angelica sinensis, 3-9 parts of fingered citron, 3-9 parts of poria cocos, 3-9 parts of fructus alpiniae oxyphyllae, 2-4 parts of American ginseng, 2-4 parts of radix pseudostellariae, 2-4 parts of schisandra chinensis, 2-4 parts of wolfberry fruits and 1-3 parts of chrysanthemum.

Preferably, the traditional Chinese medicine composition consists of the following raw material medicines in parts by weight: 8-12 parts of astragalus membranaceus, 8-12 parts of codonopsis pilosula, 5-7 parts of angelica sinensis, 5-7 parts of fingered citron, 5-7 parts of poria cocos, 5-7 parts of fructus alpiniae oxyphyllae, 2-3 parts of American ginseng, 2-3 parts of radix pseudostellariae, 2-3 parts of schisandra chinensis, 2-3 parts of wolfberry fruit and 1-2 parts of chrysanthemum.

Preferably, the traditional Chinese medicine composition consists of the following raw material medicines in parts by weight: 10 parts of astragalus, 10 parts of codonopsis pilosula, 6 parts of angelica sinensis, 6 parts of fingered citron, 6 parts of poria cocos, 6 parts of fructus alpiniae oxyphyllae, 3 parts of American ginseng, 3 parts of radix pseudostellariae, 3 parts of schisandra chinensis, 3 parts of wolfberry fruit and 2 parts of chrysanthemum.

Further, the traditional Chinese medicine composition also comprises a pharmaceutically acceptable carrier.

Furthermore, the dosage form of the traditional Chinese medicine composition is decoction, pills, tablets, mixture, capsules, granules or powder.

In a second aspect, the present invention provides a preparation method of the above-mentioned traditional Chinese medicine composition, comprising the step of weighing the raw materials according to the weight part ratio.

Preferably, the method comprises the steps of:

(1) weighing the raw material medicines according to the weight part ratio;

(2) soaking in water, decocting with strong fire for 30-60min, and filtering to obtain medicinal liquid and residue;

(3) adding water into the residue obtained in step (2), boiling with strong fire, decocting with medium fire for 30-40min, and filtering to obtain medicinal liquid;

(4) and (4) respectively taking the liquid medicines obtained in the step (2) and the step (3), combining the liquid medicines, cooling, filtering to obtain supernate, and bottling for later use.

In a third aspect, the invention provides an application of the traditional Chinese medicine composition in preparing a medicine for treating rehabilitation of tumor patients after radiotherapy and chemotherapy.

Preferably, the tumor comprises a gastric tumor, a lung tumor, a bladder tumor, a colorectal tumor.

Furthermore, the invention provides the application of the traditional Chinese medicine composition in preparing the medicine for improving the immunity of tumor patients after radiotherapy and chemotherapy.

Square solution

The astragalus and the codonopsis pilosula are monarch drugs, most of the principal symptoms of tumor patients are qi-blood deficiency and qi-blood deficiency, and qi is the power of whole body operation, so that the body can be gradually restored to normal only by taking enough qi as the power. Qi is the commander of blood, and pneumatics moves blood, links qi and blood, balances yin and yang, and maintains the characteristics of a life body, so that the combination of astragalus and codonopsis pilosula is a monarch drug, and the effects of tonifying qi and blood and maintaining yin and yang balance are realized. Chinese angelica, fingered citron, tuckahoe and sharpleaf galangal fruit are ministerial drugs. Chinese angelica: it excels at tonifying blood and is the holy drug for tonifying blood, while blood is the mother of qi, and there is enough blood as the material source of qi. Poria cocos has the effects of promoting diuresis and eliminating dampness, strengthening spleen and calming heart, has good effects of promoting diuresis and strengthening spleen, and is used for treating spleen preferring dryness and dislike of dampness. The main physiological functions of the spleen are mainly transportation and transformation, ascending the clear and keeping the blood, the continuation of the life activities of the organism and the biochemistry of qi, blood and body fluid essence depend on food essence transformed by the spleen and stomach, the spleen is called as the source of qi and blood generation, the functions of the spleen and the stomach of a patient can be enhanced and improved by adding the fingered citron and the fructus alpiniae oxyphyllae in the afterday, the modern research proves that the fingered citron and the fructus alpiniae oxyphyllae simultaneously have the anticancer effect, and the angelica, the fingered citron, the poria cocos and the fructus alpiniae oxyphyllae are jointly used as ministerial drugs to jointly play the effects of tonifying spleen and calming the heart. Adjuvant drugs: american ginseng, radix pseudostellariae, schisandra chinensis and wolfberry fruit are stewed by tonifying qi, the radix pseudostellariae is used for tonifying qi and strengthening spleen, and the radix pseudostellariae is used for promoting the secretion of saliva or body fluid and clearing away the lung-heat (both can be regarded as cold tonics), and the combination of the radix pseudostellariae and the radix pseudostellariae can enhance the effects of monarch drugs and ministerial drugs, and can effectively and balancedly enable patients to obtain lasting new yin-yang balance. The combination of the Chinese magnoliavine fruit and the barbary wolfberry fruit has sweet taste and mild property and enters liver and kidney meridians. Can nourish kidney essence, replenish essence and blood and nourish liver blood, and is generally used for treating soreness and pain of waist and knees, dizziness and tinnitus, fatigue and internal heat, spermatorrhea and diabetes caused by essence and blood deficiency. The Chinese medicine considers that 'blood is the mother of qi,' blood 'deficiency causes qi deficiency, qi deficiency indicates yang deficiency, blood' deficiency causes yin deficiency, and yin deficiency causes the body to easily generate various yin deficiency and internal heat symptoms. The human body can be ruddy in complexion and smooth in limbs only when the blood is fully distributed to all parts of the body due to continuous moistening and supply of blood flow, and the medlar is the essential medicine for tonifying and enriching the blood, so the medlar and the schisandra can better mobilize the good operation of the whole body of the heart, the liver, the spleen, the lung and the kidney. The patient can get rid of the pain early. A messenger drug: chrysanthemum: the chrysanthemum can effectively relieve some exterior symptoms of deficiency heat or heart dryness and dysphoria with smothery sensation of patients, and has the functions of clearing away heat and toxic materials and calming the heart and calming the mind. The medicines have synergistic effect, and have the effects of invigorating qi and blood, maintaining the balance of yin and yang of the patient, invigorating spleen, calming heart, clearing away heat and toxic materials, and relieving deficiency heat or heart dryness and dysphoria with smothery sensation of the patient.

Astragalus membranaceus

Sweet in flavor and warm in nature, it enters spleen and lung meridians.

Has effects in invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, inducing diuresis, relieving swelling, promoting salivation, nourishing blood, activating stagnancy, relieving arthralgia, expelling toxin, expelling pus, astringing phlegm, and promoting granulation.

For (indications), it is the essential herb for tonifying spleen qi because it is sweet and warm in entering spleen meridian.

Spleen-qi deficiency, lassitude, fatigue, poor appetite and loose stool. It is good at lifting yang and sinking, so it is especially good at treating prolapse of anus and internal organs due to chronic diarrhea caused by sinking of qi in middle-jiao due to spleen deficiency. It is the essential herb for edema due to qi deficiency because it can tonify spleen and qi to treat the root cause, induce diuresis to alleviate edema to treat the symptoms. It can tonify qi to check blood, so it is indicated for blood loss due to spleen deficiency failing to control blood. It can tonify lung qi when entering lung meridian, and is indicated for cough and weakness due to lung qi deficiency, shortness of breath, dyspnea, cough with thin and thin sensation of low voice, and laziness to speak. It can tonify qi of lung and spleen, nourish defensive qi and strengthen superficial resistance to check sweating, and is indicated for spontaneous sweating due to exterior deficiency and insecurity of defensive qi caused by spleen-lung qi deficiency, and has the actions of tonifying spleen, replenishing qi, promoting fluid production to quench thirst, and indicated for internal heat and diabetes due to qi deficiency and fluid deficiency. It has the action of nourishing blood, and is helpful for generating blood by invigorating qi, so it is also commonly indicated for blood deficiency, sallow complexion and qi-blood deficiency syndrome. It can tonify qi to promote blood circulation and tonify qi to relieve arthralgia, and is indicated for paralysis of apoplexy sequelae, manifested as numbness of skin or hemiplegia due to qi deficiency and blood stagnation in skin and malnutrition of tendons and vessels. With the actions of tonifying qi and nourishing blood, the healthy qi is vigorous, so as to achieve the effects of expelling toxin and pus, promoting tissue regeneration and astringing phlegm.

Modern research: the astragalus contains glycosides, polysaccharides and flavonoids, and also contains various components such as amino acid, protein, riboflavin, folic acid, vitamin D, beta-sitosterol, daucosterol, caffeic acid, trace elements and the like.

The pharmacological action is as follows: the astragalus polysaccharide can promote the synthesis of ribose, nucleic acid and protein, so that the cell growth is vigorous, the service life is prolonged, and the astragalus polysaccharide can resist fatigue, low temperature and influenza virus. The decoction of radix astragali and polysaccharide saponin have effects of protecting and promoting hemopoiesis, and the total saponins of radix astragali have positive inotropic effect. The total flavonoids and total glycosides of radix astragali can protect ischemic and anoxic myocardium. The decoction of radix astragali has effects of protecting kidney, eliminating urine protein and promoting urination, and has bidirectional regulating effect on blood pressure. In addition, radix astragali has antiaging, radioprotective, antiinflammatory, blood lipid reducing, blood glucose reducing, immunity enhancing, antitumor, liver protecting, and liver protecting effects.

American ginseng

Sweet, slightly bitter and cool. It enters heart, lung and kidney meridians.

Has the effects of invigorating qi, nourishing yin, clearing away heat, and promoting fluid production.

The (main) product has the similar effects of tonifying qi and relieving desertion of ginseng, has weaker potency, and is suitable for qi-yin desertion syndromes of qi-yin desertion, short breath, spontaneous perspiration, hot and sticky property, vexation, thirst, short urine, red and wet, dry stool, dry tongue and thready and rapid pulse and weakness caused by fever or profuse sweating, diarrhea, blood loss and the like which consume primordial qi and yin fluid because of being cool in property and having the functions of clearing heat, nourishing yin and promoting the production of body fluid. It is good at tonifying lung qi, nourishing lung yin and clearing lung heat, so it is indicated for shortness of breath, dyspnea, cough with little phlegm or blood-stained phlegm due to large heat consumption damaging lung qi yin. It can also tonify heart qi and nourish heart yin, and can be used for palpitation, cardiodynia, insomnia and dreaminess due to deficiency of both heart qi and yin. Can also benefit spleen qi and nourish spleen yin, and is used for anorexia, food stagnation and drinking. It can tonify qi, promote fluid production, clear heat, and is indicated for fever, profuse sweat, thirst, restlessness, fatigue, hypodynamia, and deficient and rapid pulse due to heat damaging qi and fluid.

Modern research: the American ginseng contains American ginseng saponin, polysaccharide, flavonoid, volatile oil, protein, amino acid, nucleic acid, peptide, sterol, starch, vitamin, fat, organic acid, mineral, trace elements and other components.

The pharmacological action is as follows: the American ginseng water decoction and the saponin have the functions of resisting anoxia, resisting fatigue, improving and enhancing memory, the American ginseng polysaccharide can increase white blood cells, improve immunity and resist tumors, and the American ginseng saponin has the functions of inhibiting and resisting arrhythmia, resisting stress, reducing blood fat, reducing blood sugar, tranquilizing and the like in the central nervous system.

Schisandra chinensis

Sour, sweet and warm. It enters lung, heart and kidney meridians.

Has the functions of astringing, eliminating dampness, benefiting vital energy, promoting the production of body fluid, invigorating kidney and calming heart.

For (indications), it is a key herb for chronic cough and dyspnea of deficiency type because it is sour in taste, astringent, sweet and warm and moist, and can astringe lung qi upwards and nourish kidney yin downwards. It excels at astringing lung to stop cough. It is a commonly used herb for seminal emission, enuresis and frequent urination due to insecurity of kidney essence because it is sweet, warm and astringent, enters kidney meridian and can tonify kidney, astringe seminal emission and check enuresis. The flavor is sour and astringent, and can moisten intestine and stop diarrhea, and it is indicated for deficiency-cold of spleen and kidney and chronic diarrhea. The five flavors are good, mainly contain acid, and are good at astringing lung and arresting sweating, and treating spontaneous sweating and night sweat. Sweet taste can tonify qi, and sour taste can promote the production of body fluid, so it has the actions of tonifying qi, promoting the production of body fluid, quenching thirst, and treating syndrome of heat injury, such as qi yin, hyperhidrosis and thirst. It can tonify heart and kidney, calm heart and induce tranquilization. It is indicated for restlessness, palpitation, insomnia and dream-disturbed sleep due to yin-blood deficiency, malnutrition of heart-mind or disharmony between heart and kidney.

Modern research: the product mainly contains volatile oil, organic acid, mollissima, vitamins, sugar, resin, etc. The essential component of the volatile oil is schizandrin.

The pharmacological action is as follows: it has exciting action on the nervous system and influences the exciting and inhibiting processes of cerebral cortex to balance them. Has exciting effect on respiratory system. Has antitussive and expectorant effects. Can enhance the defense ability of the organism to nonspecific stimuli. Can improve cellular immunity and antioxidant and antiaging effects. In addition, the schisandra chinensis also has the effects of benefiting gallbladder, protecting liver, inhibiting bacteria, reducing blood pressure and the like.

Codonopsis pilosula

Sweet and neutral in nature. It enters spleen and lung meridians.

Has the effects of invigorating spleen, benefiting lung, nourishing blood, and promoting fluid production.

For (indications), it is sweet in flavor and neutral in nature, enters spleen and lung meridians and has the actions of tonifying qi of spleen and lung, and is indicated for: spleen qi deficiency, lassitude, hypodynamia, poor appetite, loose stool, etc., and can be used to treat lung qi deficiency, cough, short breath, low voice, no speaking desire, etc. Has the functions of tonifying lung qi, relieving asthma and cough, and is indicated for qi deficiency of spleen and lung. Has the function of tonifying both qi and blood, and is suitable for qi and blood deficiency syndromes of pale complexion or sallow complexion, hypodynamia, dizziness, palpitation and other symptoms due to qi deficiency, failure of generating blood or failure of qi transformation due to blood deficiency. Has effects in invigorating qi and promoting fluid production, and is suitable for treating qi and fluid injury, short breath, thirst, and diabetes due to internal heat.

Modern research: the codonopsis pilosula mainly contains codonopsis pilosula polysaccharide, codonopsis pilosula glycoside, phytosterol, codonopsis pilosula lactone, flavonoid, phenolic acid, alkaloid, coumarin, inorganic elements, amino acid, trace elements and other various components.

The pharmacological action is as follows: radix Codonopsis water decoction and ethanol precipitation can regulate gastrointestinal motility, resist ulcer, and stimulate gastrin release. Radix Codonopsis alkyne glycoside can inhibit gastric acid secretion and protect gastric mucosa. The Codonopsis pilosula polysaccharide can promote growth of Bacillus bifidus, regulate proportion of high-grade intestinal flora, increase peripheral blood hemoglobin, promote spleen metabolism and hematopoiesis, and enhance organism immunity. The radix Codonopsis saponin can excite respiratory center, and the water-ethanol extractive solution and polysaccharide of radix Codonopsis can improve learning and memory ability, and has effects of improving intelligence and resisting dementia. In addition, radix Codonopsis has effects of delaying aging, resisting anoxia, resisting radiation, lowering blood sugar, regulating blood lipid and resisting myocardial ischemia.

Radix pseudostellariae

(drug property) sweet, slightly bitter and neutral. It enters spleen and lung meridians.

Has the effects of benefiting qi, invigorating spleen, promoting fluid production and moistening lung.

It can tonify spleen qi and nourish stomach yin. It is indicated for deficiency of spleen qi, deficiency of stomach yin, anorexia, lassitude, dry mouth and tongue. The qi-tonifying effect is weak, but it can nourish yin and promote the production of body fluid, and it is a clear and tonifying product in qi-tonifying, and clinically applicable to children, the elderly, physically weak and warm diseases, deficiency of qi and yin after long-term illness, lassitude, spontaneous perspiration, dry mouth and thirst, and it is not suitable for warm tonification. Because of its mild action, it is often combined with qi-tonifying, exterior-securing, yin-nourishing and fluid-generating herbs such as Huang Qi and Wu Wei Zi, etc., as a compound medicine for regulating and tonifying after illness. It can tonify lung qi, moisten lung dryness, treat lung deficiency, dry cough with little phlegm, red tongue with little coating. Modern research: mainly contains various components such as amino acid, polysaccharide, saponin, flavone, tannin, coumarin, sterol, triterpene and various trace elements.

The pharmacological action is as follows: the radix pseudostellariae water decoction, the polysaccharide, the alcohol extract and the saponin can enhance the immune function, the radix pseudostellariae water extract and the 75 percent alcohol extract have the functions of stress resistance and fatigue resistance, and the radix pseudostellariae polysaccharide has the functions of improving the memory and prolonging the service life. The radix pseudostellariae water and alcohol extract can improve the absorption function of small intestine and has therapeutic effect on spleen deficiency model. In addition, radix pseudostellariae has the effects of reducing blood sugar, reducing blood fat, relieving cough, eliminating phlegm, resisting bacteria, viruses, resisting inflammation and the like.

Poria cocos (Schw.) wolf

(property of the herb) sweet, bland and mild. It enters heart, lung, spleen and kidney meridians.

Has the effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart.

For (indications), it is sweet and bland in flavor, sweet can tonify, bland can permeate, mild in property, can eliminate pathogens and strengthen body resistance, induce diuresis without damaging body resistance, and excess is the essential herb for inducing diuresis to alleviate edema, and can be used for treating cold, heat, deficiency and excess, and various edemas. It is good at draining water dampness to make dampness not gather and phlegm not grow, so it can be indicated for dizziness and palpitation due to phlegm-fluid retention. It can tonify spleen and drain dampness to check diarrhea, so Long is fit for diarrhea due to spleen deficiency with excessive dampness. Tonify heart and spleen, calm heart and induce tranquilization. It is often combined with Huang Qi to treat palpitation, insomnia, amnesia due to deficiency of both heart and spleen and deficiency of qi and blood.

Modern research: poria contains beta-Poria cocos poly-grain (93% of dry weight), and also contains pachymic acid, protein fat, lecithin, choline, histidine, epi-canthasterol, etc.

The pharmacological action is as follows: the water decoction, alcohol extract and ether extract of Poria have diuretic, tranquilizing, antitumor and myocardial contractility enhancing effects, respectively, and the pachyman has immunity enhancing effect. The product also has effects of protecting liver, reducing blood sugar, delaying aging, and inhibiting gastric ulcer.

Finger citron

Pungent, bitter, sour and warm. It enters liver, spleen, stomach and lung meridians.

Has the effects of soothing liver, regulating qi, harmonizing stomach, relieving pain, eliminating dampness and reducing phlegm.

For (indications), it is pungent and fragrant in flavor and bitter in flavor and good at soothing liver and relieving depression, moving qi and alleviating pain. It is indicated for chest and rib distending pain due to liver qi stagnation and liver-stomach disharmony, gastric glue stuffiness and fullness. Entering spleen and stomach meridians, it can regulate qi, harmonize middle energizer and alleviate pain. It is indicated for gastric glue distending pain, nausea, vomiting and poor appetite due to qi stagnation of spleen and stomach. Bitter and damp dampness drying dampness to resolve phlegm, pungent and fragrant flavor and moving qi, so it is good at treating cough due to damp-phlegm with abundant phlegm and chest stuffiness.

Modern research: the fingered citron peel contains volatile oil, wherein the volatile oil mainly comprises limonin, limonene, terpinolene, beta-myrcene, o-cymene and the like. The fruit contains coumarins, such as bergapten, and limonolide, and flavone and polysaccharide.

Pharmacological research: the alcohol extract of fingered citron has obvious inhibiting effect on intestinal smooth muscle, has the effects of expanding coronary vessels and increasing coronary blood flow, inhibits myocardial contractility at high concentration, slows down heart rate, reduces blood pressure and protects experimental myocardial ischemia, and the fingered citron has certain effects of relieving asthma and eliminating phlegm. In addition, it has effects of anti-stress, regulating immunity, and resisting tumor.

Radix Angelicae sinensis

Sweet, pungent and warm in nature. It enters liver, heart and spleen meridians.

(efficacy) enriching blood and promoting blood circulation. Regulate menstruation, alleviate pain, moisten intestines to relieve constipation.

For its indications, Dang Gui is sweet, warm and moist in nature, good at tonifying blood, and it is the holy herb for tonifying blood. For irregular menstruation, amenorrhea and dysmenorrhea due to blood deficiency and sallow complexion, blood deficiency and blood stasis, it is sweet and pungent in flavor, so it is good at tonifying blood, both excels at activating blood, moving stagnation and alleviating pain, and is the essential herb for tonifying blood, activating blood, regulating menstruation and alleviating pain in gynecology, and it is suitable for blood deficiency and blood stasis with cold syndrome due to its warm nature. It can tonify blood to moisten intestines for relaxing bowels, so it is indicated for constipation due to blood deficiency and intestinal dryness.

Modern research: mainly contains neutral oil such as beta-pinene, alpha-pinene, camphene and the like. Contains p-methylbenzyl alcohol. 5-methoxy-2, 3-2-cresol, organic acids, saccharides, vitamins, amino acids, etc.

The pharmacological action is as follows: the extract has effects of dilating and increasing coronary blood flow, promoting generation of hemoglobin and erythrocyte, and significantly improving antithrombotic effect. In addition, the water decoction of radix Angelicae sinensis has effects of enhancing immunity, inhibiting granulation tissue hyperplasia at late stage of inflammation, resisting lipid peroxidation, resisting tumor, resisting bacteria, resisting radiation, etc.

Fructus alpiniae oxyphyllae

Pungent and warm in nature. Entering spleen and kidney meridians,

Has the effects of warming kidney, stopping nocturnal emission, reducing urination, warming spleen, stopping diarrhea and absorbing saliva.

For (indications), it has the actions of warming kidney, securing essence, reducing urination, tonifying and astringing. Treat nocturnal emission and spermatorrhea, and treat frequent micturition due to deficiency-cold of lower energizer. It can warm kidney and spleen, stimulate appetite and check saliva, treat deficiency-cold of spleen and stomach, cold pain of gastric cavity, vomiting and diarrhea, and it is indicated for deficiency-cold of middle qi, poor appetite and excessive saliva.

Modern research: the product mainly contains dibenzo-heptanes, sesquiterpenoids and volatile oils.

The pharmacological action is as follows: the fructus alpiniae oxyphyllae water extract has strong anti-fatigue capability and high-temperature resistance, and also has the effects of central inhibition, analgesia, immunosuppression, antianaphylaxis, anticancer, anti-stress, aging delaying, free radical elimination, antioxidation and the like.

Chinese wolfberry fruit

Sweet and neutral in nature. It enters liver and kidney meridians.

Has the effects of nourishing liver and kidney, replenishing vital essence and improving eyesight.

It is a key herb for nourishing kidney essence and liver blood, especially for treating kidney yin deficiency, fatigue and internal heat, manifested by soreness and pain of waist and knees, vertigo, tinnitus, impotence, seminal emission, internal heat, diabetes, blood deficiency, sallow complexion, blurred vision, etc. due to liver and kidney yin deficiency and blood deficiency.

Modern research: the product contains fructus Lycii polysaccharide, alkaloids, betaine, and hyoscyamine.

The pharmacological action is as follows: the medlar can obviously improve the immune function of organisms, can improve the phagocytosis capability of macrophages, has the regulation effect on both the cellular immune function and the humoral immune function, and has the effects of resisting oxidation, resisting aging, reducing blood fat, reducing blood sugar, resisting tumor, resisting mutagenesis, resisting radiation and reducing blood pressure. The medlar lixivium has strong bacteriostatic action on 17 bacteria such as staphylococcus aureus and the like.

(Chrysanthemum)

Sweet, bitter and slightly cold. It enters lung and liver meridians.

Has the effects of dispelling wind and heat, suppressing liver yang, clearing liver-fire, stopping bleeding, and clearing away heat and toxic materials.

It has pungent and pungent flavor and is indicated for exterior syndrome, clear and floating qi, invasion of lung by pathogenic heat, fever, headache and cough. Being cold in nature and entering liver meridian, it can clear liver heat and pacify liver yang, so it is commonly indicated for hyperactivity of liver yang, headache and vertigo. Pungent and bitter with the actions of dispersing and purging, slightly cold with the actions of clearing heat, entering liver meridian. It can not only disperse liver meridian wind-heat, but also clear liver heat to improve vision, so it is indicated for conjunctival congestion with swelling and pain due to liver meridian wind-heat or liver fire, and also for deficiency of liver and kidney essence and blood, blurred vision and blurred vision due to eye malnutrition. Being bitter in taste and slightly cold in nature, it can clear heat and remove toxicity, and is indicated for sores and abscess.

Modern research: the chrysanthemum mainly contains volatile oil, borneol acetate, camphor, chrysanthemum ketone, gossypetin, pentamethyl ether and the like. Flavonoid, luteolin, robinin, etc. Organic acid component, chlorogenic acid 3.5-0-2 caffeoyl quinic acid. In addition, it also contains chrysanthemin, adenine, choline, flavone, lignan, trace vitamin A, vitamin B, vitamin E, amino acid and acacetin, etc.

The pharmacological action is as follows: the chrysanthemum water infusion or decoction has certain antibacterial effect on staphylococcus aureus, various pathogenic bacilli and dermatophytes. The product also has inhibitory effect on influenza virus and leptospira. The flos Chrysanthemi preparation has effects of dilating coronary artery, increasing coronary blood flow, increasing myocardial oxygen consumption, relieving fever, resisting inflammation, tranquilizing mind, and shortening blood coagulation time.

Term(s) for

As used herein, an ingredient of the term "pharmaceutically acceptable" is one that is suitable for use in humans and/or animals without undue adverse side effects (such as toxicity, irritation, and allergic response), i.e., at a reasonable benefit/risk ratio.

As used herein, the term "pharmaceutically acceptable carrier" refers to a carrier for administration of a therapeutic agent, including various excipients and diluents and the like. The term refers to such pharmaceutical carriers: they are not essential active ingredients per se and are not unduly toxic after administration. Suitable carriers are well known to those of ordinary skill in the art.

As used herein, "part by weight" can be any fixed weight expressed in milligrams, grams, or kilograms (e.g., 1mg, 1g, 2g, 5g, or 1kg, etc.). For example, a composition consisting of 1 part by weight of component a and 9 parts by weight of component b may be a composition consisting of 1g of component a +9 g of component b, or 10 g of component a +90 g of component b. In the composition, the percentage content of a certain component is (parts by weight of the component/sum of parts by weight of all components) × 100%. Thus, in a composition consisting of 1 part by weight of component a and 9 parts by weight of component b, the content of component a is 10% and component b is 90%.

Dosage forms

The dosage form of the traditional Chinese medicine composition is not particularly limited, and can be any dosage form suitable for being taken by mammals; preferably, the dosage form may be selected from: decoction, pill, tablet, mixture, capsule, granule or powder.

The composition of the invention can be added with various conventional carriers or auxiliary materials required by preparing different dosage forms, such as bulking agents (such as starch), flavoring agents (such as steviosin), antioxidants or coating materials, and the like. Can be prepared into any common dosage form such as tablet, granule, capsule, pill, etc. by conventional Chinese medicinal preparation method.

Preparation method

After knowing the raw materials and their formulation used in the Chinese medicinal composition of the present invention, those skilled in the art can use various conventional methods to process the raw materials into drugs. Such processing includes, but is not limited to: pulverizing, extracting with water, extracting with organic solvent, etc. More specifically, the process comprises, for example, the steps of: weighing, pulverizing, decocting, etc.

The raw materials can be mixed and then the effective components are extracted by a proper method to prepare the traditional Chinese medicine composition; in addition, the effective components can also be extracted respectively (for example, the same or different extraction or processing methods are adopted respectively) and then combined to prepare the traditional Chinese medicine composition.

Optionally, other pharmaceutically (or dietetically or nutraceutically) acceptable carriers can be added during the preparation process.

The invention has the advantages that:

1. the traditional Chinese medicine composition is prepared by further optimizing the formula and the weight part ratio of the formula on the basis of the proved formula in the previous period, the whole formula takes 'tonifying qi and blood, strengthening spleen and calming heart, promoting the production of body fluid and clearing away the lung-heat, clearing away heat and toxic materials' as a treatment principle, the astragalus and the codonopsis pilosula in the formula are tonifying qi and blood and maintaining the balance of yin and yang and are monarch drugs together, the angelica, the fingered citron, the poria cocos and the fructus alpiniae oxyphyllae are used as ministerial drugs together, the American ginseng, the radix pseudostellariae, the schisandra chinensis and the medlar are used as adjuvant drugs together, the qi tonifying and nourishing, the qi and tonifying spleen, the body fluid and clearing away the lung-heat, and the chrysanthemum is used as a conductant drug for clearing away heat and toxic materials and calming the heart-qi. TCM holds that the occurrence and changes of diseases are complicated and complicated, but they are generally related to the two aspects of "healthy qi and pathogenic qi" of the human body. The healthy qi is usually stored in the interior, but the pathogenic factors cannot be dried. Only when the healthy qi is weak, the defensive exterior is weak, and the resistance to pathogens is weak, the pathogenic qi can enter the body in a deficient manner, the yin and yang of the body are disharmony, and the viscera are dysfunctional, the disease can occur. The invasion of pathogenic factors means that qi is always deficient, and wind, rain, cold and heat cannot be deficient, so that the pathogenic factors cannot solely injure people. When a patient is suddenly suffered from a sudden storm due to blast wind and rain without deficiency, the patient cannot be injured by pathogenic factors alone, so that the deficiency of healthy qi is the intrinsic basis for the occurrence of diseases. The experimental result shows that the traditional Chinese medicine composition has good curative effect after being used for radiotherapy and chemotherapy of tumor patients, the survival rate of the patients is greatly improved, the survival experience of the patients is greatly improved, the recurrence rate is greatly reduced, the acceptance of the patients is improved, and the medical burden of the patients is reduced.

2. The traditional Chinese medicine composition can be prepared into different dosage forms according to the needs of patients, improves the acceptability of the patients and has simple and convenient preparation method.

3. The traditional Chinese medicine composition disclosed by the invention has no toxic or side effect, no obvious adverse reaction and complication, and is safe and reliable.

Detailed Description

The present invention will be further described with reference to the following embodiments. It should be understood that these examples are for illustrative purposes only and are not intended to limit the scope of the present invention. Furthermore, it should be understood that various changes and modifications can be made by those skilled in the art after reading the disclosure of the present invention, and equivalents fall within the scope of the appended claims.

EXAMPLE 1 Chinese medicinal composition 1

5 parts of astragalus, 5 parts of codonopsis pilosula, 3 parts of angelica, 3 parts of fingered citron, 3 parts of poria cocos, 3 parts of fructus alpiniae oxyphyllae, 2 parts of American ginseng, 2 parts of radix pseudostellariae, 2 parts of schisandra chinensis, 2 parts of wolfberry fruit and 1 part of chrysanthemum.

EXAMPLE 2 Chinese medicinal composition (II)

15 parts of astragalus, 15 parts of codonopsis pilosula, 9 parts of angelica sinensis, 9 parts of fingered citron, 9 parts of poria cocos, 9 parts of fructus alpiniae oxyphyllae, 4 parts of American ginseng, 4 parts of radix pseudostellariae, 4 parts of schisandra chinensis, 4 parts of wolfberry fruit and 3 parts of chrysanthemum.

EXAMPLE 3 Chinese medicinal composition (III)

5 parts of astragalus, 15 parts of codonopsis pilosula, 3 parts of angelica, 9 parts of fingered citron, 3 parts of poria cocos, 9 parts of fructus alpiniae oxyphyllae, 2 parts of American ginseng, 4 parts of radix pseudostellariae, 2 parts of schisandra chinensis, 4 parts of wolfberry fruit and 1 part of chrysanthemum.

EXAMPLE 4 Chinese medicinal composition (IV)

15 parts of astragalus, 5 parts of codonopsis pilosula, 9 parts of angelica, 3 parts of fingered citron, 9 parts of poria cocos, 3 parts of fructus alpiniae oxyphyllae, 4 parts of American ginseng, 2 parts of radix pseudostellariae, 4 parts of schisandra chinensis, 2 parts of wolfberry fruit and 3 parts of chrysanthemum.

EXAMPLE 5 Chinese medicinal composition (V)

8 parts of astragalus, 8 parts of codonopsis pilosula, 5 parts of angelica sinensis, 5 parts of fingered citron, 5 parts of poria cocos, 5 parts of fructus alpiniae oxyphyllae, 2 parts of American ginseng, 2 parts of radix pseudostellariae, 2 parts of schisandra chinensis, 2 parts of wolfberry fruit and 1 part of chrysanthemum.

EXAMPLE 6 Chinese medicinal composition (VI)

12 parts of astragalus, 12 parts of codonopsis pilosula, 7 parts of angelica sinensis, 7 parts of fingered citron, 7 parts of poria cocos, 7 parts of fructus alpiniae oxyphyllae, 3 parts of American ginseng, 3 parts of radix pseudostellariae, 3 parts of schisandra chinensis, 3 parts of wolfberry fruit and 2 parts of chrysanthemum.

EXAMPLE 7 Chinese medicinal composition (seven)

8 parts of astragalus, 12 parts of codonopsis pilosula, 5 parts of angelica, 7 parts of fingered citron, 5 parts of poria cocos, 7 parts of fructus alpiniae oxyphyllae, 2 parts of American ginseng, 3 parts of radix pseudostellariae, 2 parts of schisandra chinensis, 3 parts of wolfberry fruit and 1 part of chrysanthemum.

EXAMPLE 8 Chinese medicinal composition (eight)

12 parts of astragalus, 8 parts of codonopsis pilosula, 7 parts of angelica sinensis, 5 parts of fingered citron, 7 parts of poria cocos, 5 parts of fructus alpiniae oxyphyllae, 3 parts of American ginseng, 2 parts of radix pseudostellariae, 3 parts of schisandra chinensis, 2 parts of wolfberry fruit and 2 parts of chrysanthemum.

EXAMPLE 9 Chinese medicinal composition (nine)

10 parts of astragalus, 10 parts of codonopsis pilosula, 6 parts of angelica sinensis, 6 parts of fingered citron, 6 parts of poria cocos, 6 parts of fructus alpiniae oxyphyllae, 3 parts of American ginseng, 3 parts of radix pseudostellariae, 3 parts of schisandra chinensis, 3 parts of wolfberry fruit and 2 parts of chrysanthemum.

Example 10 decoction

The preparation method comprises the following steps:

(1) weighing the raw materials according to the weight part ratio of any one of embodiments 1-9;

EXAMPLE 11 granules

The preparation method comprises the following steps:

(4) respectively taking the liquid medicines obtained in the step (2) and the step (3), combining the liquid medicines, cooling the liquid medicines, and filtering the liquid medicines to obtain supernate;

(5) and (4) concentrating the supernatant obtained in the step (4) under reduced pressure to obtain an extract, and vacuum drying the extract and crushing the extract into particles.

EXAMPLE 12 capsules/tablets

The preparation method comprises the following steps:

(3) adding water into the residue of step (2), boiling with strong fire, decocting with medium fire for 30-40min, and filtering to obtain medicinal liquid;

(5) and (4) concentrating the supernatant obtained in the step (4) under reduced pressure to obtain an extract, adding pharmaceutical auxiliary materials, drying in vacuum, crushing into particles, and pressing into tablets or filling into capsules.

Example 13 cell experiments

1 method of experiment

Human lung cancer A549 cell strain was cultured in 10% fetal bovine serum albumin, RPMI1640, 0.01mg/ml bovine insulin medium.

The colorectal cancer HCT116 cell line is cultured in McCoy's 5a, 10% fetal bovine serum albumin medium.

0.25% of trypsinized cells are inoculated into a 96-well plate, then a human lung cancer A549 cell strain and a colorectal cancer HCT116 cell strain are respectively divided into 2 groups, namely a control group and an experimental group, and 10 mul/well, wherein the experimental group is divided into 3 concentration treatment methods, and the concentration treatment methods respectively comprise: the liquid medicine of 0. mu.M, 25. mu.M, 75. mu.M of the Chinese medicinal composition of example 9 was treated, the control group was not treated, and the mixture was cultured in CO ₂ 3d in the incubator, then using CellTiter-GLO chemiluminescence cell activity detection kit according to CTG (CELL TITER-GLO) luminescence method for each group, measuring luminescence value at room temperature for 10min, and calculating tumor cell survival rate, tumor cell survival rate (%) - (real)Test group chemiluminescence/control group chemiluminescence) 100%.

2 results of the experiment

TABLE 1 tumor cell survival (%)

3 conclusion

The experimental results show that the traditional Chinese medicine composition can effectively inhibit the survival of tumor cells, and has more obvious proliferation inhibition effect along with the increase of the concentration of the liquid medicine, and the inhibition effect of the traditional Chinese medicine composition is in a dose-dependent relationship.

EXAMPLE 14 toxicity test

1 Experimental method

40 Kunming mice, each half of male and female, with the body weight of 18 +/-2 g, were fed adaptively for 1 week before the experiment, and diet and general conditions thereof were observed. Then dividing into 2 groups, each group comprising 20 animals, respectively experimental group and control group, fasting (medicinal liquid prepared from the Chinese medicinal composition in the examples) before administration, and taking the maximum concentration of the composition as 0.5g crude drug/ml, the maximum volume as 0.8ml/20g, the maximum tolerance of mouse is 1200 times of clinical dosage (because the death dose of mouse caused by one-time gavage of the medicament of the invention can not be obtained, LD can not be measured ₅₀ ) Gavage is carried out for 1 time/day, then the mice are raised conventionally, the general conditions of appearance, behavior, respiration, defecation, death and the like of the mice are observed, the control group is given with physiological saline with the same volume, the continuous observation is carried out for 14 days, and various physiological indexes of the mice in each group are recorded. The experimental data were presented as mean ± standard deviation using SPSS21.0 software.

2 results of the experiment

2.1 the body weight changes of the mice in each group are shown in Table 2.

TABLE 2 body weights of the mice of each group

Time	Experimental group	Control group
			0d	19.50±0.63	19.03±0.69
7d	26.32±0.56	25.98±0.77
			14d	30.42±0.81	31.13±0.54

From the results of the above table, it can be seen that there is no significant difference in body weight between the mice in the experimental group and the mice in the control group, and the mice in the experimental group show an increasing trend with time, and the problems of normal appearance, no hair fading, normal diet, no toxicity and no death of the mice are observed in the experimental process.

2.2 after the experiment is finished, the neck is dislocated to sacrifice each group of mice and each index of blood biochemistry of each group of mice is detected according to a conventional detection method, and the detection result is shown in table 3.

TABLE 3 Biochemical indexes of blood of mice in each group

	ALT(U/L)	AST(U/L)	BUN(mmol/L)
				Experimental group	43.0±6.91	149.6±80.5	11.84±3.64
Control group	41.8±9.3	153.6±67.9	12.06±5.31

The results in the table show that the biochemical indexes of the blood of each group of mice have no significant difference, and the liver, the heart, the spleen and the lung of each group of mice are taken after the experimental result, and are not changed by visual observation, the histomorphology of the mice is normal by observation under an optical microscope, and organic change caused by medicaments is not seen, which indicates that the traditional Chinese medicine composition has no pathological damage to the viscera.

Example 15 animal experiments

1 method of experiment

1.1 cell line culture

The colorectal cancer HCT116 cell strain is cultured in McCoy's 5a, 10% fetal bovine serum albumin, 100U/ml penicillin culture medium at 37 ℃ and 5% CO ₂ Culturing in an incubator under saturated humidity condition to obtain cell suspension.

1.2 Molding

70 SPF grade C57BL/6J mice with weight of 20 +/-2 g are randomly divided into 7 groups which are respectively blank group, model group, 5-fluorouracil group, experimental group, control group and control group, wherein except the blank group, all the other groups are injected into the right armpit of the mice subcutaneously by colorectal cancer HCT116 cell suspension, the mice of each group injected with cell strain within 1-7d are not treated, the mice of each group except the blank group and the model group at 8d are injected with chemotherapeutic drug 5-fluorouracil once per day, the dosage is 170mg/kg, the experimental group is additionally irrigated with 80ul of the liquid medicine prepared by the traditional Chinese medicine composition in the embodiment 9 on the basis of the 5-fluorouracil group, and the control group is additionally irrigated with 80ul of the liquid medicine (prepared by the traditional Chinese medicine composition comprising 10 parts of astragalus root, 3 parts of American ginseng, ginseng and the like, 3 parts of schisandra chinensis, 10 parts of codonopsis pilosula, 2 parts of chrysanthemum, 3 parts of radix pseudostellariae, 6 parts of poria cocos, 12 parts of white hyacinth beans and 9 parts of gordon euryale seeds, and on the basis of the 5-fluorouracil group, additionally performing intragastric perfusion on 80ul of liquid medicine (prepared from the following traditional Chinese medicine compositions: 10 parts of astragalus, 10 parts of codonopsis pilosula, 6 parts of polygonum multiflorum, 6 parts of radix bupleuri, 6 parts of poria cocos, 6 parts of dogwood, 3 parts of American ginseng, 3 parts of radix pseudostellariae, 3 parts of schisandra chinensis, 3 parts of pseudo-ginseng and 2 parts of chrysanthemum, and additionally, on the basis of 5-fluorouracil group, 80ul of gastric lavage liquid medicine (prepared by the following traditional Chinese medicine compositions) is added for comparison with three groups: 10 parts of astragalus membranaceus, 10 parts of codonopsis pilosula, 6 parts of poria cocos, 6 parts of angelica sinensis, 6 parts of fingered citron, 6 parts of fructus alpiniae oxyphyllae, 3 parts of American ginseng, 3 parts of schisandra chinensis, 3 parts of bighead atractylodes rhizome, 3 parts of pseudo-ginseng, 2 parts of fructus forsythiae and 2 parts of mint), administering for 3 weeks for each group, recording all indexes of each group of mice, killing each group of mice the next day after the experiment is finished, and recording all physiological indexes of each group of mice including immune function index and the like.

2 results of the experiment

2.1 tumor inhibition (%) was 100% based on the model group (1- (average tumor weight in administration group/average tumor weight in model group)))

The tumor inhibition rate (%) was 100% based on the 5-fluorouracil group (1- (mean tumor weight in administration group/mean tumor weight in 5-fluorouracil group)))

The tumor inhibition rates of the groups are shown in Table 4.

TABLE 4 tumor inhibition ratio (%)

2.2 taking peripheral blood of the killed mice, putting the peripheral blood into an anticoagulation tube, taking the strong exudation cells aseptically, and respectively carrying out erythrocyte C3b receptor activity detection and peritoneal macrophage C3b receptor activity detection according to a conventional method.

TABLE 5 immune function index of each group of mice

Group of	Erythrocyte C3b receptor Activity	Peritoneal macrophage C3b receptor activity
			Blank group	6.39±0.56	32.61±2.60
Model set	2.16±0.32	56.37±9.19
			5-fluorouracil group	3.31±0.15	49.66±8.35
Experimental group	4.98±0.20	39.98±3.77
			Control group	3.99±0.55	45.66±1.38
Control two groups	3.86±0.41	44.26±2.54
			Control three groups	3.52±0.37	43.10±5.69

2.3 survival rates of groups of mice after the end of dosing are shown in Table 6.

Table 6 survival rate (%)

3 conclusion

The results in the tables show that the 5-fluorouracil group has the best tumor inhibition effect (table 4), and then the experimental group, the control group and the control group are sequentially arranged, but the immune function index and the survival rate of mice in each group are the best in the experimental group, wherein the survival rate of mice in the experimental group can reach 100%, and the survival rate of 5-fluorouracil group is only 10%, which also indicates that although the tumor inhibition rate of the 5-fluorouracil group is the highest, the survival rate is not high, which suggests that the chemoradiotherapy method can effectively inhibit tumor growth for tumor (cancer) patients, but the chemoradiotherapy method cannot be tolerated for cancer patients with poor health at all, so the survival experience of the patients is very poor, and the survival rate is low. The results of experimental groups show that the traditional Chinese medicine composition has a certain tumor inhibition rate, can improve the immunity of patients to a great extent, greatly relieves the side effects of radiotherapy and chemotherapy to the patients, improves the living experience of the patients, and can greatly improve the survival rate of the patients. The contrast group, the two groups and the three groups have certain improvement effects on tumor inhibition rate and immunity improvement, but the effects of the traditional Chinese medicine composition are still very different (P is less than 0.01) compared with the effects of the experimental group, which also shows that the traditional Chinese medicine composition has synergistic effects among the medicines, and has the effects of tonifying qi and blood, strengthening spleen, calming heart, promoting the production of body fluid, clearing away the lung-heat, and clearing away heat and toxic materials.

Typical cases

Case 1: the Wang XX is a male, is 54 years old, is diagnosed as 'high molecular adenocarcinoma in gastric cancer' by the first hospital in Jiaxing city of Zhejiang province, and has symptoms of nausea, vomiting, anemia, insomnia and the like after operation treatment.

Case 2: plum XX, male, 61 years old, small cell lung cancer, causes adverse drug non-therapeutic injury after chemotherapy, has obvious gastrointestinal reaction, and is manifested by nausea, vomiting, abdominal distension and diarrhea, and also has leucopenia, thrombocytopenia and anemia. The emotion is very low, the confidence of life is lost once, after the traditional Chinese medicine formula is taken, the nausea and vomiting are improved in three weeks, the abdominal distension is relieved, the diarrhea is stopped, the excrement is basically recovered to be normal, the blood routine examination is performed in the third week after the chemotherapy, the normal condition is basically recovered, and the medicine is stopped after the traditional Chinese medicine is taken for one year. Now it is still healthy.

Case 3: yao XX, male, 94 years old, inventor's father 82 years old, 9 months old, was identified as bladder cancer by Shanghai Xinhua hospital, initial bladder resection in 10 months of the year, and survived for 9 years after surgery, wherein the Chinese medicinal composition of the invention was decocted for 5 years without other medicines and without other treatments (after bladder cancer surgery), and bladder cancer was examined five years later in the urological department of Jiashan county hospital!

After operation, especially after radiotherapy and chemotherapy, general bodies of tumor patients mostly show great pain and can not be insisted on, various diseases appear, but the traditional Chinese medicine summarizes the situation as ' deficiency of vital qi ', imbalance of yin and yang and qi, deficiency of both qi and blood (qi and blood do not nourish the meridians), deficiency of body fluid, dysfunction of spleen and stomach transportation and transformation, generally speaking, weakness, poor appetite and lusterless complexion are mainly complained by the traditional Chinese medicine, the process of ' struggle against ' of vital qi and pathogenic qi is carried out, the vicious of the pathogenic qi and the vital qi determines the advance and retreat of diseases, the pathogenic qi surpasses the positive qi to cause the disease, the cured state of the patients is not ideal, the tumor is easy to transfer and recur, the human body feels extremely bad, the five-year survival rate is low, otherwise, the ideal support of ' conditioning ' of the bodies ' can be properly followed up in time, the functions of the bodies can be reasonably adjusted and supplemented from the inside, the bodies can be recovered, the tumor patients, especially the general weakness of the radiotherapy and chemotherapy patients, the symptoms of anorexia, asthenia, etc. can be relieved or disappeared, the human body feels good, and the living and living quality can be greatly improved! The five-year survival rate is greatly improved. However, no special commercial product is available for such patients in view of the commercial products currently available on the market. The product of the invention is composed of a variety with dual purposes of medicine and food, can achieve no toxic and side effect, is safe and reassuring to use, and has very unique treatment effect! The fruit is a very hard and exquisite one.

The foregoing is only a preferred embodiment of the present invention, and it should be noted that, for those skilled in the art, various modifications and additions can be made without departing from the principle of the present invention, and these should also be considered as the protection scope of the present invention.

Claims

1. A traditional Chinese medicine composition for treating rehabilitation of tumor patients after radiotherapy and chemotherapy is characterized by comprising the following raw material medicines in parts by weight: 5-15 parts of astragalus membranaceus, 5-15 parts of codonopsis pilosula, 3-9 parts of angelica sinensis, 3-9 parts of fingered citron, 3-9 parts of poria cocos, 3-9 parts of fructus alpiniae oxyphyllae, 2-4 parts of American ginseng, 2-4 parts of radix pseudostellariae, 2-4 parts of schisandra chinensis, 2-4 parts of wolfberry fruits and 1-3 parts of chrysanthemum.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 8-12 parts of astragalus membranaceus, 8-12 parts of codonopsis pilosula, 5-7 parts of angelica sinensis, 5-7 parts of fingered citron, 5-7 parts of poria cocos, 5-7 parts of fructus alpiniae oxyphyllae, 2-3 parts of American ginseng, 2-3 parts of radix pseudostellariae, 2-3 parts of schisandra chinensis, 2-3 parts of wolfberry fruit and 1-2 parts of chrysanthemum.

3. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 10 parts of astragalus, 10 parts of codonopsis pilosula, 6 parts of angelica sinensis, 6 parts of fingered citron, 6 parts of poria cocos, 6 parts of fructus alpiniae oxyphyllae, 3 parts of American ginseng, 3 parts of radix pseudostellariae, 3 parts of schisandra chinensis, 3 parts of wolfberry fruit and 2 parts of chrysanthemum.

4. The Chinese medicinal composition of any one of claims 1-3, wherein the Chinese medicinal composition further comprises a pharmaceutically acceptable carrier.

5. The traditional Chinese medicine composition according to any one of claims 1 to 3, wherein the dosage form of the traditional Chinese medicine composition is decoction, pill, tablet, mixture, capsule, granule or powder.

6. The preparation method of the traditional Chinese medicine composition as claimed in any one of claims 1 to 3, which is characterized by comprising the step of weighing the raw materials according to the weight part ratio.

7. The method for preparing according to claim 6, characterized in that it comprises the steps of:

(1) weighing the raw material medicines according to the weight part ratio;

(4) and (4) respectively taking the liquid medicines obtained in the step (2) and the step (3), combining, cooling, filtering to obtain supernate, and bottling for later use.

8. The use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of a medicament for the treatment of the recovery of a patient with tumor after radiotherapy and chemotherapy.

9. The use of claim 8, wherein said tumor comprises a tumor of the stomach, lung, bladder, or colorectal.

10. The use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of a medicament for enhancing immunity of a tumor patient after radiotherapy and chemotherapy.