CN114848734A - Traditional Chinese medicine composition for perianal nursing - Google Patents
Traditional Chinese medicine composition for perianal nursing Download PDFInfo
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- CN114848734A CN114848734A CN202210705792.7A CN202210705792A CN114848734A CN 114848734 A CN114848734 A CN 114848734A CN 202210705792 A CN202210705792 A CN 202210705792A CN 114848734 A CN114848734 A CN 114848734A
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- perianal
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Classifications
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- Organic Chemistry (AREA)
- Zoology (AREA)
- Animal Husbandry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention discloses a traditional Chinese medicine composition for perianal nursing, which is prepared from the following raw materials in parts by weight: 140-150 parts of radix sophorae flavescentis, 140-150 parts of aloe, 140-150 parts of rheum officinale, 100-110 parts of fructus cnidii, 100-110 parts of fructus kochiae, 100-110 parts of gallnut, 100-110 parts of lithospermum, 70-80 parts of selfheal, 100-110 parts of radix stemonae, 100-110 parts of rhizoma atractylodis, 70-80 parts of golden cypress, 100-110 parts of liquorice, 100-110 parts of mirabilite, 100-110 parts of alum and 10-11 parts of borneol. The invention has precise and appropriate compatibility of raw materials, is used for treating local inflammation and hot pain of anus, bleeding or pruritus ani caused by six exogenous pathogenic factors and seven internal injury after anorectal diseases or anal diseases, has obvious effect on primary pruritus ani, less side effect, convenient carrying and use and comfortable feeling after use, and is an ideal treatment mode for anorectal diseases. Has strong practical application value.
Description
Technical Field
The invention particularly relates to a traditional Chinese medicine composition for perianal nursing.
Background
The primary pruritus ani is a common perianal nerve dysfunctional skin disease, has the main clinical characteristics of stubborn pruritus and long-term disunion, is generally limited to perianal area, can spread to pudendum and perineum sometimes, and is common in young and strong years. Primary anal pruritus is usually not accompanied by perianal skin lesions, and perianal localized pruritus is the main clinical manifestation, rather than the ultimate diagnosis. The data show that 1-5% of people have anal pruritus symptoms, males are more common than females, and are more common in people between 40-60 years of age, however, it can affect people of any age, including children.
The key problem of western medicine diagnosis and treatment of anal pruritus in the past is to find out the symptoms causing the anal pruritus and then treat the symptoms according to the etiology, however, the etiology causing the anal pruritus is unclear in many cases. The medicines such as high-concentration corticosteroid hormone preparations, anti-inflammatory medium preparations and various sedatives are mostly used for local application, and the medicines can only relieve pruritus transiently, but have high recurrence rate, so that the long-term curative effect is not ideal, and the medicines have a plurality of side effects or adverse effects. However, the operation treatment undoubtedly causes certain trauma and sequelae to the patients, and is difficult to accept by some patients.
The traditional Chinese medicine treatment for primary pruritus ani has achieved remarkable curative effects at present, and meanwhile, the traditional Chinese medicine treatment is concerned by more patients. The fumigation and washing treatment of primary anal pruritus is widely developed in anorectal departments at present, but most of the medicine proportions do not have the scientificity of traditional Chinese medicine syndrome differentiation treatment and have no clinical test support; and the existing anorectal external washing powder with definite curative effect, good stability and convenient carrying has few varieties.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition for perianal nursing, which is prepared from the following raw materials in parts by weight:
140-150 parts of radix sophorae flavescentis, 140-150 parts of aloe, 140-150 parts of rheum officinale, 100-110 parts of fructus cnidii, 100-110 parts of fructus kochiae, 100-110 parts of gallnut, 100-110 parts of lithospermum, 70-80 parts of selfheal, 100-110 parts of radix stemonae, 100-110 parts of rhizoma atractylodis, 70-80 parts of golden cypress, 100-110 parts of liquorice, 100-110 parts of mirabilite, 100-110 parts of alum and 10-11 parts of borneol.
Further, the medicine is prepared from the following raw materials in parts by weight:
142.9 parts of radix sophorae flavescentis, 142.9 parts of aloe, 142.9 parts of rheum officinale, 107.1 parts of fructus cnidii, 107.1 parts of fructus kochiae, 107.1 parts of gallnut, 107.1 parts of lithospermum, 71.4 parts of selfheal, 107.1 parts of radix stemonae, 107.1 parts of rhizoma atractylodis, 71.4 parts of golden cypress, 107.1 parts of liquorice, 107.1 parts of mirabilite, 107.1 parts of alum and 10.7 parts of borneol.
Furthermore, the rhubarb is raw rhubarb, the stemona root is raw sessile stemona root, the atractylodes rhizome is raw swordlike atractylodes rhizome, and the amur corktree bark is raw amur corktree bark.
Furthermore, the traditional Chinese medicine composition is a preparation prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.
Further, the formulation is an external preparation.
Furthermore, the external preparation is a solution, a paste, an emulsion, a film or a powder.
The invention also provides a preparation method of the traditional Chinese medicine composition, which comprises the following steps:
(1) weighing the raw materials according to the proportion;
(2) grinding the raw materials into powder, or extracting with water or organic solvent, and adding adjuvants or auxiliary components.
The invention also provides application of the composition in preparing a medicament for treating perianal diseases.
Further, the medicament is used for treating the perianal red swelling and hot pain, bleeding and/or pruritus, and preferably, the medicament is used for treating primary anal pruritus.
The invention finally provides the application of the composition in preparing the medicines for clearing heat, eliminating dampness, dispelling wind, relieving itching, reducing swelling and relieving pain.
In the composition, the lightyellow sophora root and the amur corktree bark have the effects of clearing away heat and toxic materials, eliminating dampness and relieving itching, the rhubarb has the effects of clearing away heat and toxic materials, promoting blood circulation and removing blood stasis, the swordlike atractylodes rhizome has the effects of dispelling wind and eliminating dampness, the Chinese gall has the effects of astringing dampness and healing sore, the aloe and the alum have the effects of killing parasites and relieving itching, and the belvedere fruit and the common cnidium fruit have the effects of eliminating dampness, dispelling wind and relieving itching, and the belvedere fruit and the common cnidium fruit are ministerial medicines; the medicines such as mirabilite and the like are used for assisting in clearing heat and reducing swelling, and astringing and relieving depletion, and the medicines such as the selfheal, the lithospermum and the like have the effects of purging pathogenic fire and calming the liver, and clearing heat and cooling blood; borneol is pungent and fragrant, helps transdermal absorption of various medicines, enhances the effects of relieving swelling and pain, and liquorice coordinates various medicines, wherein is a guiding drug; the medicines have the effects of clearing heat, eliminating dampness, dispelling wind, relieving itching, reducing swelling and relieving pain.
The invention has precise and appropriate compatibility of raw materials, is used for treating local inflammation and hot pain of anus, bleeding or pruritus ani caused by six exogenous pathogenic factors and seven internal injury after anorectal diseases or anal diseases, has obvious effect on primary pruritus ani, less side effect, convenient carrying and use and comfortable feeling after use, and is an ideal treatment mode for anorectal diseases. Has strong practical application value.
Obviously, many modifications, substitutions, and variations are possible in light of the above teachings of the invention, without departing from the basic technical spirit of the invention, as defined by the following claims.
The present invention will be described in further detail with reference to the following examples. This should not be understood as limiting the scope of the above-described subject matter of the present invention to the following examples. All the technologies realized based on the above contents of the present invention belong to the scope of the present invention.
Detailed Description
Example 1 preparation of a composition according to the invention
The formula is as follows: 142.9g of radix sophorae flavescentis, 142.9g of aloe, 142.9g of raw rhubarb, 107.1g of fructus cnidii, 107.1g of fructus kochiae, 107.1g of gallnut, 107.1g of lithospermum, 71.4g of selfheal, 107.1g of raw radix stemonae, 107.1g of raw rhizoma atractylodis, 71.4g of raw cortex phellodendri, 107.1g of liquorice, 107.1g of mirabilite, 107.1g of alum and 10.7g of borneol.
The preparation method and the use method are as follows: weighing the raw materials according to the ratio, adding 10-25 times of ml/g of water, decocting for 10min, filtering, taking the filtrate, and cooling to obtain a solution; when in use, the anus is heated to 37-45 ℃ for fumigation and washing for 15min every time, and the time is 1 time every night.
The preparation method and the use method comprise the following steps: weighing the raw materials according to the proportion, mixing, crushing, sieving with an 8-mesh sieve, and subpackaging to obtain powder; when in use, 70g of the medicinal liquor is taken at one time, soaked or decocted for 10min by 1000-1500 ml of boiling water, and then the anus is fumigated and washed at the water temperature of 37-45 ℃ for 15min every time, and 1 time every night.
Example 2 preparation of the inventive Agents
The formula is as follows: 140g of radix sophorae flavescentis, 140g of aloe, 140g of raw rhubarb, 100g of fructus cnidii, 100g of fructus kochiae, 100g of gallnut, 100g of lithospermum, 70g of selfheal, 100g of raw radix stemonae, 100g of raw rhizoma atractylodis, 70g of raw cortex phellodendri, 100g of liquorice, 100g of mirabilite, 100g of alum and 10g of borneol.
The preparation method and the use method are as follows: weighing the raw materials according to the ratio, adding 10-25 times of ml/g of water, decocting for 10min, filtering, taking the filtrate, and cooling to obtain a solution; when in use, the anus is heated to 37-45 ℃ for fumigation and washing for 15min every time, and the time is 1 time every night.
The preparation method and the use method comprise the following steps: weighing the raw materials according to the proportion, mixing, crushing, sieving with an 8-mesh sieve, and subpackaging to obtain powder; when in use, 70g of the medicinal liquor is taken at one time, soaked or decocted for 10min by 1000-1500 ml of boiling water, and then the anus is fumigated and washed at the water temperature of 37-45 ℃ for 15min every time, and 1 time every night.
Example 3 preparation of the inventive Agents
The formula is as follows: 150g of radix sophorae flavescentis, 150g of aloe, 150g of raw rhubarb, 110g of fructus cnidii, 110g of fructus kochiae, 110g of gallnut, 110g of lithospermum, 80g of selfheal, 110g of raw radix stemonae, 110g of raw rhizoma atractylodis, 80g of raw cortex phellodendri, 110g of liquorice, 110g of mirabilite, 110g of alum and 11g of borneol
The preparation method and the use method are as follows: weighing the raw materials according to the ratio, adding 10-25 times of ml/g of water, decocting for 10min, filtering, taking the filtrate, and cooling to obtain a solution; when in use, the anus is heated to 37-45 ℃ for fumigation and washing for 15min every time, and the time is 1 time every night.
The preparation method and the use method comprise the following steps: weighing the raw materials according to the proportion, mixing, crushing, sieving with an 8-mesh sieve, and subpackaging to obtain powder; when in use, 70g of the medicinal liquor is taken at one time, soaked or decocted for 10min by 1000-1500 ml of boiling water, and then the anus is fumigated and washed at the water temperature of 37-45 ℃ for 15min every time, and 1 time every night.
The advantageous effects of the present invention are further illustrated by the following test examples
Test example 1 clinical application study
1 data and method
1.1 general data
80 patients with primary anal pruritus diagnosed by anorectal department of Sichuan province II in 2019 to 2020 in 12 months and 4 months are selected, and 40 patients in the observation group and the control group are randomly allocated. The observation group consisted of 18 men and 22 women, with patients having a mean age (37.3 + -10.9) years and a mean course of disease (15.3 + -8.4) months. In the control group, 21 men and 19 women were treated, and the patients were aged at the mean age (38.2. + -. 11.2) and at the mean course (16.1. + -. 7.2) month. The general data comparison of sex, age, Body Mass Index (BMI), and complications of two groups of patients did not make any statistical difference (P > 0.05). The study passes the examination and approval of the ethical committee of the hospital, and the patients and the family members sign informed consent before treatment to approve the study informed consent.
1.2 inclusion and exclusion criteria
Inclusion criteria were: (1) the age is 18-60 years. (2) According to 2012 "Chinese medicine society (ZYYXH/T322-341-: the diagnosis and treatment guidelines of common diseases of anorectal department of traditional Chinese medicine and the expert consensus of traditional Chinese medicine treatment for skin pruritus meet the diagnosis standard of primary anal pruritus. (3) No perianal infectious diseases. Exclusion criteria: (1) patients with secondary pruritus ani caused by rectal prolapse, eczema, anal fistula and the like, complicated with anorectal diseases and needing operation treatment. (2) Combined with serious basic diseases of cardiovascular, liver, kidney and blood systems, malignant tumor and tuberculosis. (3) Dysentery and severe diarrhea are combined. (4) Combined with urinary incontinence. (5) Pregnant or lactating women. (6) Patients with mental diseases. (7) An invasive instrument treats a patient. (8) Patients who fall after follow-up visit after treatment.
1.3 methods of treatment
1.3.1 the observation group adopts Sichuan famous traditional Chinese medicine Xuttian Han professor and Maohong professor to prepare a traditional Chinese medicine preparation 'anti-inflammatory washing powder' (powder prepared according to example 1) according to a traditional Chinese medicine theoretical system and clinical practice experiences, the Sichuan medicine is prepared into a character Z20200190000, the preparation standard of the anti-inflammatory washing powder refers to 'quality standard research of the anti-inflammatory washing powder', each bag is 70g, 1 bag is soaked or decocted by 1000-1500 ml of boiling water, and the anus can be fumigated and washed when the water temperature is about 40 ℃. Fumigating and washing for 15min each time, 1 time per night.
1.3.2 the control group is hip-bathed with warm water of potassium permanganate solution at a ratio of 1: 5000 for 15min each time and 1 time per night.
The treatment course is 1 treatment course for 7 days, and 3 treatment courses are continued. During the treatment period, the mood is kept pleasant, the diet is light, and greasy and uncooked foods and spicy stimulating foods are contraindicated. Keep anus clean and dry, and the anus is cleaned by warm water, but not by strong alkaline soap and hot water. The underpants are not easy to be too tight and hard when the underpants are changed frequently.
1.4 Observation index
1.4.1 index of clinical symptoms of pruritus ani refers to the literature of clinical research guiding principle of new Chinese medicine and diagnosis and treatment of anorectal diseases, etc. to make a scoring table of pruritus ani symptoms. Clinical anal symptom scores (degree of anal pruritus and interval of onset of anal pruritus) were compared before, 1 week after, 2 weeks after, and 3 weeks after treatment in two groups of patients.
(1) Evaluation of anal itching degree was performed by Visual Analogue Scale (VAS): the score range is 0-3, and the higher the score is, the more obvious the itching degree is represented.
(2) The pruritus onset frequency was evaluated using the anal pruritus onset scale: firstly, the attack is more than or equal to 2 times every day for 6 minutes; ② attack 1 time and 4 minutes every day; ③ attack 1 time and 2 minutes for more than 3 days; and 0min without attack. The higher the score, the more frequent the onset of anal itching.
1.4.2 perianal sign indexes are formulated into perianal signs (lichen sample change and skin eczema sample change) tables according to documents such as Chinese medicine new drug clinical research guiding principle, Chinese anorectal disease diagnosis and treatment and the like.
(1) Perianal licheniform lesion rating scale: firstly, the perianal area has no moss-like lesion and is divided into 0 point; ② coarse perianal with slight thickening, no fold change, 1 minute; ③ 2 minutes for perianal roughness and thickening with plica protrusion; fourthly, the perianal radial rhagades are thick, the moss is pathological, and the rubber tree is rough when the rubber tree touches the anus for 3 minutes. Higher scores represent more pronounced lichenification of the skin.
(2) Perianal skin eczematoid change rating scale: skin has no eczema-like change, 0 point; ② there are red papules and pimple on the skin, no blister and no exudation, 1 point; ③ the skin has red papules, papules and blisters, and a small amount of exudation, 2 points; skin has red papule, herpes simplex and blister, accompanied with obvious punctate or platelet erosion and exudation, 3 minutes. Higher scores represent more pronounced eczematoid changes in the skin.
1.4.3 follow-up records the recurrence rate of patients at 1, 3, 6 months after treatment.
1.5 the therapeutic index is drawn up according to the Chinese medicine industry Standard of the people's republic of China, 1994, diagnostic therapeutic Standard of anorectal diseases in traditional Chinese medicine (ZY/T001.7-94) and other documents. And (3) curing: the pruritus ani symptom completely disappears, and no new skin damage occurs around the anus; the skin loss is resolved to more than 90 percent of the original area, and no recurrence is caused during the follow-up period; the effect is shown: the pruritus symptom is obviously relieved, perianal skin lesion is obviously improved, the skin lesion is subsided to more than 70 percent of the original area, and no aggravation or relapse occurs during the follow-up period; the method has the following advantages: the pruritus symptom is relieved, perianal skin lesion is not aggravated, the skin lesion is subsided to reach more than 50% of the original area, and no aggravation or relapse occurs during follow-up; and (4) invalidation: the pruritus symptom is not obviously improved, perianal skin lesion is not relieved or new skin lesion occurs, and the symptoms are aggravated or recurred during follow-up.
1.6 statistical analysis
Data were analyzed using statistical software SPSS 22.0. MeteringData to
Indicated, comparisons were made using t-test or repeated measures analysis of variance. The counting data is expressed as [ n (%)]Denotes, adopts × 2 The test was compared. With P<A difference of 0.05 is statistically significant.
2 results
2.1 results and efficacy comparison between two groups
The total effective rate of treatment is 95.0% for the observed group patients and 75.0% for the control group patients, and the difference between the two groups has statistical significance (P < 0.05). (see Table 1).
TABLE 1 comparison of the results of the two therapeutic groups [ case (%) ]
2.2 evaluation of two groups of clinical symptoms of pruritus ani
2.2.1 comparison of two sets of anal itch degree scores the results of repeated measures of variance analysis showed that time effects can affect the anal itch degree score (P <0.05), and there were interactive effects between the time points and the groups (P < 0.05). Simple effect results show that compared differences of anal itching degree scores before treatment of two groups have no statistical significance (P is more than 0.05); the anal itching degree scores of the observed groups were lower than the control group at 1 week, 2 weeks and 3 weeks after treatment (all P < 0.05). Both groups had a decreased anal itching score at each time point after treatment (mean P <0.05) compared to before treatment, and both groups had a decreased anal itching score to a minimum level at 3 weeks after treatment. See table 2.
TABLE 2 comparison of anal itching degree scores in two groups
The method comprises the following steps of dividing,
compared with the control group, the compound of the formula, △ P<0.05; compared with the treatment before the treatment, * P<0.05; compared with the treatment period of 1 week after the treatment, & P<0.05; compared with the treatment period of 2 weeks after the treatment, # P<0.05。
2.2.2 comparison of the anal pruritus onset interval scores of the two groups before treatment, the anal pruritus onset frequency of the two groups is not different (P > 0.05). After treatment, the frequency of onset of anal pruritus was reduced in both groups (both P <0.05), and the observed group was superior to the control group. See table 3.
Table 3 two groups of anal itch episode interval scores were compared,
2.3 evaluation of two groups of perianal signs
2.3.1 comparison of perianal bryoid lesion scores in the two groups, repeated measures of anoanalysis of variance showed that time effects could affect the anal itching score (P <0.05), and there was an interaction effect between the time points and the groups (P < 0.05). Simple effect results show that compared differences of perianal skin moss-like change scores before treatment of two groups have no statistical significance (P is more than 0.05); the perianal skin moss-like scores of the observed group were all lower than those of the control group (all P <0.05) at 1 week, 2 weeks and 3 weeks after treatment. Perianal cutaneous lichenification scores were reduced at each time point after treatment (mean P <0.05) in both groups compared to before treatment, with the observed group perianal cutaneous lichenification scores decreasing to a minimum level 3 weeks after treatment, while the control group minimum level occurred 2 weeks after treatment. See table 4.
Table 4 two groups of perianal moss-like lesion scores were compared,
compared with the control group, the compound of the formula, △ P<0.05; compared with the treatment before the treatment, * P<0.05; compared with the treatment period of 1 week after the treatment, & P<0.05; compared with the treatment period of 2 weeks after the treatment, # P<0.05。
2.3.2 comparison of perianal skin eczematous change scores in two groups
Before treatment, there was no significant difference in perianal skin eczematoid scores in the two groups (P > 0.05). After treatment, the perianal skin eczematous change scores of the two groups are reduced (the average P is less than 0.05), and the observed group is obviously superior to the control group. See table 5.
Table 5 two groups of perianal skin eczematous change scores were scored comparatively,
compared with the treatment before the treatment, * P<0.05。
2.4 comparison of relapse status in two groups
The patient's recurrence rate was recorded at 1, 3, 6 months post-treatment with follow-up visits, respectively, with the observed group being significantly lower than the control group (mean P < 0.05). See table 6.
TABLE 6 two sets of relapse rates comparison [ case (%) ]
Discussion 3
Primary pruritus ani is a common dermatosis symptom, is an irritant feeling of skin around the anus, is often accompanied by strong scratching or rubbing impulse, is embarrassed and uncomfortable, and is possibly aggravated at night or after defecation, often scratches cause local skin injury or infection, and is paroxysmal attack. In recent years, traditional Chinese medicine fumigation therapy is widely applied to anorectal diseases, and the mechanism of the fumigation therapy is that the anorectal diseases are in the lower part of the organism, and damp-heat evil is easy to invade, so that the anorectal diseases are mostly downward-flowing damp-heat syndrome. The common clinical fumigation and washing prescription is based on the kushen decoction and is added with various medicines for clearing heat, removing toxicity, reducing swelling and the like. The Chinese medicinal materials have antiviral, antibacterial or bacteriostatic chemical components, and can inhibit the growth of various bacteria, and achieve antiinflammatory effect, thereby improving exudation, congestion, edema and blood circulation of wound surface, promoting granulation growth, controlling or inhibiting infection, and accelerating wound healing. The warm stimulation of the steam can relieve the spasm of the sphincter, obviously reduce the resting pressure of the anal canal, improve the local blood circulation and lymphatic circulation, smooth the channels and collaterals and relieve the pain. Has incomparable advantages in the aspects of promoting wound healing, eliminating edema, relieving pain and itching and the like.
The traditional Chinese medicine classifies the pruritus ani into the category of pruritus ani and the like, and the traditional Chinese medicine considers that the disease is caused by two major types of external causes and internal causes, and the external causes of pruritus ani are mostly disturbed by wind, dampness, heat evil, insect poison and the like, so that the theory that pruritus belongs to wind, excessive heat causes pain, and slight heat causes itching is provided; the internal factors are caused by deficiency of qi and blood in the zang-fu organs, failing to nourish the muscle and skin striae, and blood deficiency producing wind, so it is said that: blood deficiency can produce wind, and wind accumulation can cause itching. The preparation of the anti-inflammatory washing powder (consisting of lightyellow sophora root, amur corktree bark, Chinese gall, sessile stemona root, rhubarb, common selfheal fruit-spike, sinkiang arnebia root, belvedere fruit, common cnidium fruit, aloe, mirabilite, alum, swordlike atractylodes rhizome, liquoric root, borneol and other medicines) is used, and the clinical application result after the formula is treated by the traditional Chinese medicine dialectical theory shows that the observed total effective rate is 95.5 percent which is obviously superior to 75.0 percent of the control group (P is less than 0.05). The anal itching clinical symptom scores and perianal signs scores of the two groups are reduced, and the observed group is obviously lower than the control group (P < 0.05). The observed group of recurrence rates at 1, 3, 6 months after treatment was significantly lower than the control group (P < 0.05). No adverse reactions occurred in both groups during the treatment period.
In conclusion, the anti-inflammatory washing powder fumigation-washing therapy has definite effect on primary anal pruritus, low recurrence rate and high safety, and is worthy of popularization and application in clinic.
Claims (10)
1. A traditional Chinese medicine composition for perianal nursing is characterized in that: the composition is prepared from the following raw materials in parts by weight:
140-150 parts of radix sophorae flavescentis, 140-150 parts of aloe, 140-150 parts of rheum officinale, 100-110 parts of fructus cnidii, 100-110 parts of fructus kochiae, 100-110 parts of gallnut, 100-110 parts of lithospermum, 70-80 parts of selfheal, 100-110 parts of radix stemonae, 100-110 parts of rhizoma atractylodis, 70-80 parts of golden cypress, 100-110 parts of liquorice, 100-110 parts of mirabilite, 100-110 parts of alum and 10-11 parts of borneol.
2. The traditional Chinese medicine composition according to claim 1, characterized in that: the composition is prepared from the following raw materials in parts by weight:
142.9 parts of radix sophorae flavescentis, 142.9 parts of aloe, 142.9 parts of rheum officinale, 107.1 parts of fructus cnidii, 107.1 parts of fructus kochiae, 107.1 parts of gallnut, 107.1 parts of lithospermum, 71.4 parts of selfheal, 107.1 parts of radix stemonae, 107.1 parts of rhizoma atractylodis, 71.4 parts of golden cypress, 107.1 parts of liquorice, 107.1 parts of mirabilite, 107.1 parts of alum and 10.7 parts of borneol.
3. The traditional Chinese medicine composition according to claim 1 or 2, wherein: the rhubarb is raw rhubarb, the stemona root is raw stemona root, the atractylodes rhizome is raw atractylodes rhizome, and the phellodendron bark is raw phellodendron bark.
4. The traditional Chinese medicine composition according to claim 1, wherein: the preparation is prepared by taking medicinal powder of raw material medicines, or water or organic solvent extracts of the raw material medicines as active ingredients and adding pharmaceutically acceptable auxiliary materials.
5. The traditional Chinese medicine composition according to claim 4, wherein: the preparation is an external preparation.
6. The traditional Chinese medicine composition according to claim 5, wherein: the external preparation is a solution, an ointment, an emulsion, a film agent or powder.
7. A method for preparing the Chinese medicinal composition of any one of claims 1 to 6, which is characterized by comprising the following steps: it comprises the following steps:
(1) weighing the raw materials according to the proportion of claim 1;
(2) grinding the raw materials into powder, or extracting with water or organic solvent, and adding adjuvants or auxiliary components.
8. Use of a composition according to any one of claims 1 to 6 in the manufacture of a medicament for the treatment of a perianal disorder.
9. Use according to claim 8, characterized in that: the medicine is used for treating the perianal red swelling and hot pain, bleeding and/or pruritus, and preferably, the medicine is used for treating primary anal pruritus.
10. Use of the composition of any one of claims 1 to 6 for the preparation of a medicament for clearing heat, eliminating dampness, dispelling wind, relieving itching, reducing swelling and alleviating pain.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060033070A (en) * | 2004-10-14 | 2006-04-19 | 김태균 | Hip-bath compositions for treatment of herorrhoids or gynecological diseases, and hip-bath bag containing it |
| CN104922566A (en) * | 2015-07-09 | 2015-09-23 | 江西中医药大学附属医院 | Anus lotion and preparation method thereof |
| CN106729087A (en) * | 2016-12-29 | 2017-05-31 | 合肥安德生制药有限公司 | A kind of Chinese medicine compound prescription external preparation for treating pruritus ani |
| CN107184703A (en) * | 2017-06-06 | 2017-09-22 | 上海市中医医院 | A kind of three sub- anti-itching lotions and its preparation technology and application |
-
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- 2022-06-21 CN CN202210705792.7A patent/CN114848734B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR20060033070A (en) * | 2004-10-14 | 2006-04-19 | 김태균 | Hip-bath compositions for treatment of herorrhoids or gynecological diseases, and hip-bath bag containing it |
| CN104922566A (en) * | 2015-07-09 | 2015-09-23 | 江西中医药大学附属医院 | Anus lotion and preparation method thereof |
| CN106729087A (en) * | 2016-12-29 | 2017-05-31 | 合肥安德生制药有限公司 | A kind of Chinese medicine compound prescription external preparation for treating pruritus ani |
| CN107184703A (en) * | 2017-06-06 | 2017-09-22 | 上海市中医医院 | A kind of three sub- anti-itching lotions and its preparation technology and application |
Non-Patent Citations (1)
| Title |
|---|
| 徐廷翰等, pages: 85 - 2 * |
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