CN112439020A - Traditional Chinese medicine composition and tincture for treating chronic eczema and preparation method thereof - Google Patents

Traditional Chinese medicine composition and tincture for treating chronic eczema and preparation method thereof Download PDF

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CN112439020A
CN112439020A CN202011315741.0A CN202011315741A CN112439020A CN 112439020 A CN112439020 A CN 112439020A CN 202011315741 A CN202011315741 A CN 202011315741A CN 112439020 A CN112439020 A CN 112439020A
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chinese medicine
traditional chinese
treating chronic
chronic eczema
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钱霞
李少华
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First Hospital Of Nanchang
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First Hospital Of Nanchang
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Abstract

The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition and tincture for treating chronic eczema and a preparation method thereof, wherein the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis, 18-22 parts of borneol, 1-3 parts of cantharis and 18-22 parts of salicylic acid; the Chinese medicinal composition is in the form of tincture, ointment, plaster, gel or patch; the tincture also contains 75% ethanol, and the Chinese medicinal composition is soaked in 75% ethanol. The invention has the beneficial effects that: the external liniment has the characteristics of novel formula, convenient and easy preparation and obvious treatment effect, has good effects of relieving itching, diminishing inflammation and decrustation, has thorough treatment, difficult recurrence and small side effect, relieves the pain of patients with chronic eczema, has obvious clinical effect, and makes up the defects of hormone external liniments.

Description

Traditional Chinese medicine composition and tincture for treating chronic eczema and preparation method thereof
Technical Field
The invention belongs to the field of traditional Chinese medicine preparations, and particularly relates to a traditional Chinese medicine composition and tincture for treating chronic eczema and a preparation method thereof.
Background
Eczema is a skin inflammatory reaction with severe pruritus caused by various internal and external factors, the cause of the skin inflammatory reaction is not completely clear, the cause of the skin inflammatory reaction is complex and difficult to determine, subjective symptoms such as severe pruritus are easy to recur, and the skin inflammatory reaction can be prolonged for years and cannot be cured. The chronic stage has infiltrative hypertrophy, pigmentation, rough and scale-like surface, erythema and pimple as main components, severe pruritus, repeated attack, dense and flaky erythema, papule, herpes simplex or blister, exudation, unclear border, small papule and herpes simplex scattered around, erosion and incrustation, and pustule or scab can appear in secondary infection.
At present, the western medicine for treating chronic eczema mainly depends on 4 types of medicines, namely, corticoids, immunosuppressants, antihistamines and moisturizing emollients, one or more medicines are generally selected for matching or alternative use, glucocorticoid medicines are mostly adopted for external use, and the western medicine for treating eczema has a quick response but has the defects of incomplete treatment, easy relapse and large side effect.
Disclosure of Invention
In order to solve the problems, the invention provides a traditional Chinese medicine composition and tincture for treating chronic eczema and a preparation method thereof.
The technical scheme adopted by the invention is as follows: a traditional Chinese medicine composition for treating chronic eczema is characterized by comprising the following raw material medicines: radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, Borneolum Syntheticum, Mylabris, and salicylic acid.
Wherein, the radix euphorbiae lantu is used as a medicine, has the functions of eliminating phlegm, removing food retention and relieving pain, and can be used for treating various skin diseases by external application;
ku Shen can clear heat and dry dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, and leprosy; kurarinone has anti-HBV and anti-HCV effects; the alkali has effects of inhibiting proliferation of liver cancer cell strain and killing it directly; the ethyl acetate extract of radix Sophorae Flavescentis has effect in inhibiting animal and plant pathogenic bacteria; the matrine has antibacterial, virus inhibiting and interferon inducing effects;
raw Da Huang is indicated for sores and ulcers and swelling due to external application.
Unprocessed ban Xia is applied externally to eliminate carbuncle and swelling, remove goiter and tumor, cure tinea and itch and prevent skin canceration.
Indigo naturalis, antiviral is the main efficacy of external application of indigo naturalis, and the topical application of the composition on the skin with pathological changes can kill viruses and fungi on the surface of the skin, prevent the disease from deteriorating, and prevent skin canceration from having good prevention effect on modern human high-grade skin cancer; the natural indigo has obvious functions of eliminating and inhibiting various pathogenic bacteria and microorganisms when being externally applied, the Chinese medicament can prevent the infection of the wound after the trauma occurs, has a certain pain relieving function, and can quickly relieve the symptoms when people have adverse symptoms such as furuncle, gall, skin red swelling and the like by externally applying the natural indigo. The natural indigo also has the efficacy of detoxification, can accelerate the decomposition and metabolism of a plurality of toxins in human bodies, can be directly externally applied to the natural indigo when people are bitten by poisonous snakes or mosquitoes in daily life, can relieve the poisoning symptoms of human beings as soon as possible, can prevent the diffusion of snake venom, and can obviously improve the gall after poisoning.
The borneol has the effects of clearing away heat and toxic materials, preventing corrosion, promoting granulation, inducing resuscitation and refreshing mind, and has a better curative effect on treating agglomeration.
Cantharis is used for abdominal mass and lump, stubborn ringworm in the elderly, scrofula, carbuncle and cellulitis, malignant sore and dead muscle and the like, is prepared into cantharis wine by matching with ethanol, has good itching relieving effect, can block malignant circulation caused by pruritus, regulates disordered cerebral cortex functions and eliminates stimulation to skin due to scratching; meanwhile, the red-leading function of the cantharis wine can accelerate local blood circulation and promote metabolism, thereby improving local nutrition and leading the pathological tissues of the moss ratio to absorb and fade.
Salicylic acid is externally applied to treat herpes zoster, has the effects of promoting blood circulation to remove blood stasis, relieving pain and removing toxicity, diminishing inflammation, reducing swelling and resisting infection.
The traditional Chinese medicine considers that the main pathogenic factors of the chronic eczema are wind evil, damp evil, heat evil, blood fluke excessiveness and the like, and the treatment is based on the principles of dispelling wind and eliminating dampness, clearing heat and removing toxicity, nourishing blood and moistening dryness, and activating blood and dissolving stasis, so that the effects of dispelling pathogenic factors and strengthening body resistance and relieving itching are achieved.
In the formula, the Chinese wolfsbane root with the functions of resolving masses and resisting bacteria, the lightyellow sophora root with the bitter taste and cold nature and capable of killing parasites and relieving itching, the raw rhubarb with the functions of purging fire, cooling blood, removing stasis and detoxifying, the natural indigo with cold nature and flavor and capable of eliminating sore swelling, erysipelas and macula and the raw pinellia tuber are adopted.
In addition, considering that the skin of an affected part is mainly erythema pimple and has rough and scaly surface, the low-concentration cantharidin is adopted as a foaming agent, and the cutin removing and inflammation diminishing properties of salicylic acid are taken as auxiliary materials, so that thick scabs can be fully removed, and itching and swelling can be well relieved.
The used medicine has good effects of inhibiting and removing skin erythema and pimple, relieving itching, diminishing inflammation, removing blood stasis and detoxifying, and the medicines are combined to directly reach the pathological change part, thereby fully playing the curative effect.
Further, the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis and borneol. 18-22 parts of cantharis, 1-3 parts of cantharis and 18-22 parts of salicylic acid, and clinical comparison data prove that the proportioning is reasonable.
Further, the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 50 parts of radix sophorae flavescentis, 20 parts of raw rhubarb, 20 parts of raw pinellia ternate, 20 parts of indigo naturalis, 20 parts of borneol, 2 parts of cantharis and 20 parts of salicylic acid, and the optimal proportion is determined through clinical comparison data.
Further comprises one or more of caulis Hederae sinensis, Kochiae fructus, Saviae Miltiorrhizae radix, radix Angelicae sinensis, herba Erigerontis, fructus Citri Sarcodactylis, Aloe, herba Rosmarini officinalis, folium Artemisiae Argyi, and Bulbus Lilii.
The ivy has the effects of resisting bacteria, removing toxicity, removing deposited toxins, and having high transdermal absorption rate, and the whole ivy can be used as a medicine, has the effects of dispelling wind-damp, promoting blood circulation and relieving swelling, and has the treatment effects on traumatic injury, lumbocrural pain, rheumatic arthritis and other diseases. The functional indications are as follows: dispel wind, promote diuresis, activate blood, relieve swelling, pacify liver, and remove toxicity.
Kochiae fructus, dispelling pathogenic wind and relieving itching, treating eczema, neurodermatitis, etc., and inhibiting dermatophyte. For carbuncle, recorded in the selection of new Chinese herbal medicine therapy data: broom cypress fruit and Laiyao Zi are respectively one or two. Decocting with slow fire, and washing the affected part while hot for 10-15 min 2 times a day.
Dan Shen has the actions of resisting bacteria, astringing, healing the epidermis and removing scars, and is recorded in the book Yu Fang (elbow and back) for treating the heat, oil and fire burning, removing pain and promoting granulation, and is finely adjusted with water, two jin of mutton tallow is taken, three upper and three lower portions are decocted, and the sore is smeared. The total tanshinone of Saviae Miltiorrhizae radix has inhibitory effect on Staphylococcus aureus and its drug-resistant strain; the external use of the salvia miltiorrhiza injection has the functions of promoting wound healing and intestinal anastomosis healing; tanshinone A has effect in inducing tumor cell differentiation; salvianic acid A has the function of inhibiting fibroblast proliferation in vitro.
Dang Gui, for resolving abscess and dissipating swelling, is decocted to have antibacterial action.
The erigeron breviscapus has the effects of promoting blood circulation, activating skin cells, dispelling cold, relieving exterior syndrome, dispelling wind, removing dampness, promoting blood circulation, relaxing muscles and tendons, promoting digestion, relieving pain and the like.
The bergamot has special effects on acne, eczema and ulcer, can improve long-term itching and dryness, and is helpful for relieving inflammation and killing skin infection.
Aloe, improve rough skin, tranquilize and resist inflammation, the mucus (protein) in Aloe is core ingredient of polysaccharides such as arboran A Baloe mannanase, etc., and the mucus material is important ingredient for preventing cell aging and treating chronic allergy; the aloe can promote healing, has the effect of promoting healing of aloe on the back of an artificial wound mouse, and can shorten the healing days for the aloe in an artificial conjunctival edema rabbit. The aloe juice preparation has protective effect on skin wound, burn and x-ray local irradiation; the aloin A, wound hormone and polypeptide mannan (Ke-2) have functions of resisting virus infection, promoting wound healing and recovery, diminishing inflammation, killing bacteria, absorbing heat, relieving swelling, softening skin, and maintaining cell activity, and the combination of curdlan and wound healing activity.
Rosemary, which activates cells, promotes blood circulation, and stimulates hair regeneration.
The folium artemisiae argyi is externally used for eliminating dampness, relieving itching and inhibiting skin bacteria and mite regeneration.
Lily root, radix Lilii, for increasing skin elasticity, it is good to be pounded into paste in Yebai, for treating swelling and sore on the side of the treatment in Bao Hui Zheng Yan Fang (prescription of Hui Zheng). For craniocerebral ulcer, it is recorded in Shengjie Zong Lu (holy book of treatises), Baihe, Huangbai, Bai Ji, and Ricinus seed, fifty grains (ground). The powder is prepared by mixing sodium sulfate and water as cake paste, and is applied on more than three days; for eczema and eczema, it is smashed and applied on Lily in Bin Hu Ji Jian Fang (Collection of simple prescription from Bin lake).
Further, the traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis, 18-22 parts of borneol, 1-3 parts of cantharis, 18-22 parts of salicylic acid, 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily. Clinical comparative data prove that the proportioning setting is reasonable.
Furthermore, the dosage form of the traditional Chinese medicine composition is tincture, ointment, plaster, gel or patch. The Chinese medicinal composition can be prepared into various dosage forms, and is suitable for different conditions.
The application of the traditional Chinese medicine composition for treating chronic eczema in preparing medicines for treating chronic eczema, dermatitis or keratoderma.
The tincture of the traditional Chinese medicine composition for treating chronic eczema is characterized by further comprising 900 ml of 75% ethanol and 1100ml of ethanol. Tincture is a clear liquid preparation prepared by extracting or dissolving raw medicines with ethanol with specified concentration, and can also be prepared by diluting with fluid extract. The concentration of the tincture is otherwise specified, and each 100ml of the tincture contains 10g of drug (medicinal materials); the other tincture is equivalent to 20g of the original medicine per 100 ml.
A method for preparing a Chinese medicinal composition for treating chronic eczema is characterized by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis and Mylabris, adding Borneolum Syntheticum and salicylic acid, and mixing well to obtain the final product. The preparation is simple and easy to realize.
A method for preparing a Chinese medicinal tincture for treating chronic eczema is characterized by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, and Mylabris, adding Borneolum Syntheticum and salicylic acid, soaking in 900 ml 75% ethanol for 7 days, stirring for several times, filtering, and packaging in glass bottles.
The invention has the beneficial effects that: the invention has the characteristics of novel formula, convenient and easy preparation and obvious treatment effect, has good effects of relieving itching, diminishing inflammation and decrustation, has thorough treatment, difficult recurrence and small side effect, has good effect in 70 cases of clinical observation, relieves the pain of patients with chronic eczema, has obvious clinical effect and makes up the defects of hormone external liniments.
Detailed Description
The following is a description of specific embodiments of the present invention.
The invention relates to a traditional Chinese medicine composition for treating chronic eczema, which comprises the following raw material medicines: radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, Borneolum Syntheticum, Mylabris, and salicylic acid.
Wherein, the radix euphorbiae lantu is used as a medicine, has the functions of eliminating phlegm, removing food retention and relieving pain, and can be used for treating various skin diseases by external application;
ku Shen can clear heat and dry dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, and leprosy; kurarinone has anti-HBV and anti-HCV effects; the alkali has effects of inhibiting proliferation of liver cancer cell strain and killing it directly; the ethyl acetate extract of radix Sophorae Flavescentis has effect in inhibiting animal and plant pathogenic bacteria; the matrine has antibacterial, virus inhibiting and interferon inducing effects;
raw rhubarb for external use can treat diseases such as sores and ulcers and pyogenic infections;
unprocessed ban Xia is applied externally to eliminate carbuncle and swelling, remove goiter and tumor, cure tinea and itch and prevent skin canceration.
Indigo naturalis, antiviral is the main efficacy of external application of indigo naturalis, and the topical application of the composition on the skin with pathological changes can kill viruses and fungi on the surface of the skin, prevent the disease from deteriorating, and prevent skin canceration from having good prevention effect on modern human high-grade skin cancer; the natural indigo has obvious functions of eliminating and inhibiting various pathogenic bacteria and microorganisms when being externally applied, the Chinese medicament can prevent the infection of the wound after the trauma occurs, has a certain pain relieving function, and can quickly relieve the symptoms when people have adverse symptoms such as furuncle, gall, skin red swelling and the like by externally applying the natural indigo. The natural indigo also has the efficacy of detoxification, can accelerate the decomposition and metabolism of a plurality of toxins in human bodies, can be directly externally applied to the natural indigo when people are bitten by poisonous snakes or mosquitoes in daily life, can relieve the poisoning symptoms of human beings as soon as possible, can prevent the diffusion of snake venom, and can obviously improve the gall after poisoning.
The borneol has the effects of clearing away heat and toxic materials, preventing corrosion, promoting granulation, inducing resuscitation and refreshing mind, and has a better curative effect on treating agglomeration.
Cantharis is used for abdominal mass and lump, stubborn ringworm in the elderly, scrofula, carbuncle and cellulitis, malignant sore and dead muscle and the like, is prepared into cantharis wine by matching with ethanol, has good itching relieving effect, can block malignant circulation caused by pruritus, regulates disordered cerebral cortex functions and eliminates stimulation to skin due to scratching; meanwhile, the red-leading function of the cantharis wine can accelerate local blood circulation and promote metabolism, thereby improving local nutrition and leading the pathological tissues of the moss ratio to absorb and fade.
Salicylic acid is externally applied to treat herpes zoster, has the effects of promoting blood circulation to remove blood stasis, relieving pain and removing toxicity, diminishing inflammation, reducing swelling and resisting infection.
The traditional Chinese medicine considers that the main pathogenic factors of the chronic eczema are wind evil, damp evil, heat evil, blood fluke excessiveness and the like, and the treatment is based on the principles of dispelling wind and eliminating dampness, clearing heat and removing toxicity, nourishing blood and moistening dryness, and activating blood and dissolving stasis, so that the effects of dispelling pathogenic factors and strengthening body resistance and relieving itching are achieved.
In the formula, the Chinese wolfsbane root with the functions of resolving masses and resisting bacteria, the lightyellow sophora root with the bitter taste and cold nature and capable of killing parasites and relieving itching, the raw rhubarb with the functions of purging fire, cooling blood, removing stasis and detoxifying, the natural indigo with cold nature and flavor and capable of eliminating sore swelling, erysipelas and macula and the raw pinellia tuber are adopted.
In addition, considering that the skin of an affected part is mainly erythema pimple and has rough and scaly surface, the low-concentration cantharidin is adopted as a foaming agent, and the cutin removing and inflammation diminishing properties of salicylic acid are taken as auxiliary materials, so that thick scabs can be fully removed, and itching and swelling can be well relieved.
The used medicine has good effects of inhibiting and removing skin erythema and pimple, relieving itching, diminishing inflammation, removing blood stasis and detoxifying, and the medicines are combined to directly reach the pathological change part, thereby fully playing the curative effect.
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis and borneol. 18-22 parts of cantharis, 1-3 parts of cantharis and 18-22 parts of salicylic acid, and clinical comparison data prove that the proportioning is reasonable.
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 50 parts of radix sophorae flavescentis, 20 parts of raw rhubarb, 20 parts of raw pinellia ternate, 20 parts of indigo naturalis, 20 parts of borneol, 2 parts of cantharis and 20 parts of salicylic acid, and the optimal proportion is determined through clinical comparison data.
Also comprises one or more of caulis Hederae sinensis, Kochiae fructus, Saviae Miltiorrhizae radix, radix Angelicae sinensis, flos Hibisci, fructus Citri Sarcodactylis, Aloe, herba Rosmarini officinalis, folium Artemisiae Argyi, and Bulbus Lilii.
The ivy has the effects of resisting bacteria, removing toxicity, removing deposited toxins, and having high transdermal absorption rate, and the whole ivy can be used as a medicine, has the effects of dispelling wind-damp, promoting blood circulation and relieving swelling, and has the treatment effects on traumatic injury, lumbocrural pain, rheumatic arthritis and other diseases. The functional indications are as follows: dispel wind, promote diuresis, activate blood, relieve swelling, pacify liver, and remove toxicity.
Kochiae fructus, dispelling pathogenic wind and relieving itching, treating eczema, neurodermatitis, etc., and inhibiting dermatophyte. For carbuncle, recorded in the selection of new Chinese herbal medicine therapy data: broom cypress fruit and Laiyao Zi are respectively one or two. Decocting with slow fire, and washing the affected part while hot for 10-15 min 2 times a day.
Dan Shen has the actions of resisting bacteria, astringing, healing the epidermis and removing scars, and is recorded in the book Yu Fang (elbow and back) for treating the heat, oil and fire burning, removing pain and promoting granulation, and is finely adjusted with water, two jin of mutton tallow is taken, three upper and three lower portions are decocted, and the sore is smeared. The total tanshinone of Saviae Miltiorrhizae radix has inhibitory effect on Staphylococcus aureus and its drug-resistant strain; the external use of the salvia miltiorrhiza injection has the functions of promoting wound healing and intestinal anastomosis healing; tanshinone A has effect in inducing tumor cell differentiation; salvianic acid A has the function of inhibiting fibroblast proliferation in vitro.
Dang Gui, for resolving abscess and dissipating swelling, is decocted to have antibacterial action.
The erigeron breviscapus has the effects of promoting blood circulation, activating skin cells, dispelling cold, relieving exterior syndrome, dispelling wind, removing dampness, promoting blood circulation, relaxing muscles and tendons, promoting digestion, relieving pain and the like.
The bergamot has special effects on acne, eczema and ulcer, can improve long-term itching and dryness, and is helpful for relieving inflammation and killing skin infection.
Aloe, improve rough skin, tranquilize and resist inflammation, the mucus (protein) in Aloe is core ingredient of polysaccharides such as arboran A Baloe mannanase, etc., and the mucus material is important ingredient for preventing cell aging and treating chronic allergy; the aloe can promote healing, has the effect of promoting healing of aloe on the back of an artificial wound mouse, and can shorten the healing days for the aloe in an artificial conjunctival edema rabbit. The aloe juice preparation has protective effect on skin wound, burn and x-ray local irradiation; the aloin A, wound hormone and polypeptide mannan (Ke-2) have functions of resisting virus infection, promoting wound healing and recovery, diminishing inflammation, killing bacteria, absorbing heat, relieving swelling, softening skin, and maintaining cell activity, and the combination of curdlan and wound healing activity.
Rosemary, which activates cells, promotes blood circulation, and stimulates hair regeneration.
The folium artemisiae argyi is externally used for eliminating dampness, relieving itching and inhibiting skin bacteria and mite regeneration.
Lily root, radix Lilii, for increasing skin elasticity, it is good to be pounded into paste in Yebai, for treating swelling and sore on the side of the treatment in Bao Hui Zheng Yan Fang (prescription of Hui Zheng). For craniocerebral ulcer, it is recorded in Shengjie Zong Lu (holy book of treatises), Baihe, Huangbai, Bai Ji, and Ricinus seed, fifty grains (ground). The powder is prepared by mixing sodium sulfate and water as cake paste, and is applied on more than three days; for eczema and eczema, it is smashed and applied on Lily in Bin Hu Ji Jian Fang (Collection of simple prescription from Bin lake).
The traditional Chinese medicine composition comprises the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis, 18-22 parts of borneol, 1-3 parts of cantharis, 18-22 parts of salicylic acid, 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily. Clinical comparative data prove that the proportioning setting is reasonable.
The dosage form of the traditional Chinese medicine composition is tincture, ointment, plaster, gel or patch. The Chinese medicinal composition can be prepared into various dosage forms, and is suitable for different conditions.
The tincture is a clear liquid preparation prepared by extracting or dissolving raw material medicines with ethanol with specified concentration, and can also be prepared by diluting with fluid extract.
Ethanol 75% is used for disinfection. Because too high a concentration of alcohol forms a protective film on the surface of bacteria to prevent it from entering the body of bacteria, it is difficult to kill bacteria thoroughly. If the alcohol concentration is too low, the bacteria can enter, but the protein in the body can not be coagulated, and the bacteria can not be completely killed, and 75% ethanol is suitable for disinfection.
The application of the traditional Chinese medicine composition for treating chronic eczema in preparing medicines for treating chronic eczema, dermatitis or keratoderma. The traditional Chinese medicine composition for treating chronic eczema can be used for treating dermatitis or keratoderma besides eczema.
The tincture of the traditional Chinese medicine composition for treating chronic eczema also comprises 1000ml of 75% ethanol. The tincture is a clear liquid preparation prepared by extracting or dissolving raw material medicines with ethanol with specified concentration, and can also be prepared by diluting with fluid extract. The concentration of the tincture is otherwise specified, and each 100ml of the tincture contains 10g of drug (medicinal materials); the other tincture is equivalent to 20g of the original medicine per 100 ml.
A Chinese medicinal composition for treating chronic eczema is prepared by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, and Mylabris, adding Borneolum Syntheticum and salicylic acid, and mixing. The preparation is simple and easy to realize.
A method for preparing a Chinese medicinal tincture for treating chronic eczema comprises pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, and Mylabris, adding Borneolum Syntheticum and salicylic acid, soaking in 1000ml 75% ethanol for 7 days, stirring for several times, vacuum filtering, and packaging in glass bottles.
Compared with the prior art, the invention has the characteristics of novel formula, convenient and easy preparation and obvious treatment effect, has good effects of relieving itching, diminishing inflammation and decrustation, has thorough treatment, small side effect and obvious clinical effect by observing 70 cases, is not easy to relapse, relieves the pain of patients with chronic eczema, has obvious clinical effect and makes up the defects of hormone external liniments.
Example 1
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines: radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, Borneolum Syntheticum, Mylabris, and salicylic acid.
Wherein, the radix euphorbiae lantu is used as a medicine, has the functions of eliminating phlegm, removing food retention and relieving pain, and can be used for treating various skin diseases by external application;
ku Shen can clear heat and dry dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pruritus vulvae, eczema, skin pruritus, scabies, tinea, and leprosy; kurarinone has anti-HBV and anti-HCV effects; the alkali has effects of inhibiting proliferation of liver cancer cell strain and killing it directly; the ethyl acetate extract of radix Sophorae Flavescentis has effect in inhibiting animal and plant pathogenic bacteria; the matrine has antibacterial, virus inhibiting and interferon inducing effects;
raw Da Huang is indicated for sores and ulcers and swelling due to external application. (ii) a
Unprocessed ban Xia is applied externally to eliminate carbuncle and swelling, remove goiter and tumor, cure tinea and itch and prevent skin canceration.
Indigo naturalis, antiviral is the main efficacy of external application of indigo naturalis, and the topical application of the composition on the skin with pathological changes can kill viruses and fungi on the surface of the skin, prevent the disease from deteriorating, and prevent skin canceration from having good prevention effect on modern human high-grade skin cancer; the natural indigo has obvious functions of eliminating and inhibiting various pathogenic bacteria and microorganisms when being externally applied, the Chinese medicament can prevent the infection of the wound after the trauma occurs, has a certain pain relieving function, and can quickly relieve the symptoms when people have adverse symptoms such as furuncle, gall, skin red swelling and the like by externally applying the natural indigo. The natural indigo also has the efficacy of detoxification, can accelerate the decomposition and metabolism of a plurality of toxins in human bodies, can be directly externally applied to the natural indigo when people are bitten by poisonous snakes or mosquitoes in daily life, can relieve the poisoning symptoms of human beings as soon as possible, can prevent the diffusion of snake venom, and can obviously improve the gall after poisoning.
The borneol has the effects of clearing away heat and toxic materials, preventing corrosion, promoting granulation, inducing resuscitation and refreshing mind, and has a better curative effect on treating agglomeration.
Cantharis is used for abdominal mass and lump, stubborn ringworm in the elderly, scrofula, carbuncle and cellulitis, malignant sore and dead muscle and the like, is prepared into cantharis wine by matching with ethanol, has good itching relieving effect, can block malignant circulation caused by pruritus, regulates disordered cerebral cortex functions and eliminates stimulation to skin due to scratching; meanwhile, the red-leading function of the cantharis wine can accelerate local blood circulation and promote metabolism, thereby improving local nutrition and leading the pathological tissues of the moss ratio to absorb and fade.
Salicylic acid is externally applied to treat herpes zoster, has the effects of promoting blood circulation to remove blood stasis, relieving pain and removing toxicity, diminishing inflammation, reducing swelling and resisting infection.
The traditional Chinese medicine considers that the main pathogenic factors of the chronic eczema are wind evil, damp evil, heat evil, blood fluke excessiveness and the like, and the treatment is based on the principles of dispelling wind and eliminating dampness, clearing heat and removing toxicity, nourishing blood and moistening dryness, and activating blood and dissolving stasis, so that the effects of dispelling pathogenic factors and strengthening body resistance and relieving itching are achieved.
In the formula, the Chinese wolfsbane root with the functions of resolving masses and resisting bacteria, the lightyellow sophora root with the bitter taste and cold nature and capable of killing parasites and relieving itching, the raw rhubarb with the functions of purging fire, cooling blood, removing stasis and detoxifying, the natural indigo with cold nature and flavor and capable of eliminating sore swelling, erysipelas and macula and the raw pinellia tuber are adopted.
In addition, considering that the skin of an affected part is mainly erythema pimple and has rough and scaly surface, the low-concentration cantharidin is adopted as a foaming agent, and the cutin removing and inflammation diminishing properties of salicylic acid are taken as auxiliary materials, so that thick scabs can be fully removed, and itching and swelling can be well relieved.
The used medicine has good effects of inhibiting and removing skin erythema and pimple, relieving itching, diminishing inflammation, removing blood stasis and detoxifying, and the medicines are combined to directly reach the pathological change part, thereby fully playing the curative effect.
Example 2
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis, 18-22 parts of borneol, 1-3 parts of cantharis and 18-22 parts of salicylic acid, and clinical comparison data prove that the proportioning is reasonable.
Example 3
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis, 18-22 parts of borneol, 1-3 parts of cantharis and 18-22 parts of salicylic acid, and also comprises one or more of 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily.
Example 4
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 47 parts of radix euphorbiae lantu, 47 parts of radix sophorae flavescentis, 18 parts of raw rhubarb, 18 parts of raw pinellia ternate, 18 parts of indigo naturalis, 18 parts of borneol, 1 part of cantharis and 18 parts of salicylic acid, and clinical comparison data prove that the proportion is reasonable to set.
Example 5
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 53 parts of radix euphorbiae lantu, 53 parts of radix sophorae flavescentis, 22 parts of raw rhubarb, 22 parts of raw pinellia ternate, 22 parts of indigo naturalis, 22 parts of borneol, 3 parts of cantharis and 22 parts of salicylic acid, and the clinical comparison data proves that the proportioning is reasonable.
Example 6
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 53 parts of radix euphorbiae lantu, 53 parts of radix sophorae flavescentis, 22 parts of raw rhubarb, 18 parts of raw pinellia ternate, 18 parts of indigo naturalis, 18 parts of borneol, 1 part of cantharis and 18 parts of salicylic acid, and the clinical comparison data proves that the proportioning is reasonable.
Example 7
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 50 parts of radix sophorae flavescentis, 20 parts of raw rhubarb, 20 parts of raw pinellia ternate, 20 parts of indigo naturalis, 20 parts of borneol, 2 parts of cantharis and 20 parts of salicylic acid, and the optimal proportion is determined through clinical comparison data.
Example 8
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 50 parts of radix sophorae flavescentis, 20 parts of raw rhubarb, 20 parts of raw pinellia ternate, 20 parts of indigo naturalis, 20 parts of borneol, 2 parts of cantharis, 20 parts of salicylic acid, 1g of ivy, 1g of fructus kochiae, 1g of salvia miltiorrhiza, 1g of angelica sinensis, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe and 1g of rosemary.
Example 9
The dosage form of the Chinese medicinal composition of any one of embodiments 1 to 8 may be a tincture, an ointment, a plaster, a gel or a patch.
The tincture is a clear liquid preparation prepared by extracting or dissolving raw material medicines with ethanol with specified concentration, and can also be prepared by diluting with fluid extract. The ethanol can dissolve sebum, loosen epidermis, and absorb water in skin. The ethanol also has effects of relaxing muscles and tendons, promoting blood circulation, dilating peripheral blood vessel, enhancing permeability of peripheral blood vessel, and promoting drug absorption, so as to exert pharmacological effect of the drugs in the medicated liquor. Meanwhile, the alcohol has the functions of disinfection, sterilization and itching relief.
The ointment is a semisolid external preparation with certain consistency prepared by uniformly mixing a medicament and a proper matrix. The common base is divided into oleaginous, water-soluble and emulsion base, wherein the ointment prepared from the emulsion base and easy to be coated is called cream.
Plasters are preparations which are sticky and which are intended for external application. Is prepared by mixing the medicine and proper matrix. Is usually uniformly coated on cotton cloth or other backing materials, and sometimes a plurality of small holes are arranged on the surface of the backing material. After being attached to the skin, the patch gradually exerts the drug effect at the body temperature. Common uses include adhesive plaster (i.e. adhesive plaster) and plaster (e.g. wound plaster).
The gel is thick liquid or semisolid preparation prepared by the drug and auxiliary materials capable of forming gel and prepared into solution, suspension or emulsion. Gels are typically topically applied to the skin and body cavities (e.g., nasal, vaginal, and rectal). Emulsion type gelling agents are also known as emulsors. Gelling agents made from a polymeric matrix (e.g., tragacanth, etc.) may also be referred to as mucilages. A gel formed by small particles of a small-molecular inorganic drug (such as aluminum hydroxide) existing in a liquid in a network structure belongs to a two-phase dispersion system and is also called a suspension type gel. Suspension gels can be thixotropic, semi-solid at rest and liquid when stirred or shaken.
The patch is a sheet-like preparation which can be adhered to the skin and the medicine can produce systemic or local effect. Modern transdermal absorption preparation is a patch or a patch medicine which is absorbed through skin, can quickly and durably enter the whole body according to the dosage required by the disease condition through a controlled release mechanism.
The Chinese medicinal composition can be made into various dosage forms, and is suitable for different disease occurrence positions and disease development stages.
Example 10
A traditional Chinese medicine composition tincture for treating chronic eczema comprises the following raw materials in parts by weight:
50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rhubarb, 20g of raw pinellia ternate, 20g of natural indigo
Borneol 20g cantharis 2g salicylic acid 20g 75% ethanol 1000ml,
wherein 75% ethanol is used for disinfection. Because too high a concentration of alcohol forms a protective film on the surface of bacteria to prevent it from entering the body of bacteria, it is difficult to kill bacteria thoroughly. If the alcohol concentration is too low, the bacteria can enter, but the protein in the body can not be coagulated, and the bacteria can not be completely killed, and 75% ethanol is suitable for disinfection.
The prescription is based on:
the traditional Chinese medicine considers that the main pathogenic factors of the chronic eczema are wind evil, damp evil, heat evil, blood fluke excessiveness and the like, and the treatment is based on the principles of dispelling wind and eliminating dampness, clearing heat and removing toxicity, nourishing blood and moistening dryness, and activating blood and dissolving stasis, so that the effects of dispelling pathogenic factors and strengthening body resistance and relieving itching are achieved.
In the formula, the Chinese wolfsbane root with the functions of resolving masses and resisting bacteria, the lightyellow sophora root with the bitter taste and cold nature and capable of killing parasites and relieving itching, the raw rhubarb with the functions of purging fire, cooling blood, removing stasis and detoxifying, the natural indigo with cold nature and flavor and capable of eliminating sore swelling, erysipelas and macula and the raw pinellia tuber are adopted.
In addition, considering that the skin of an affected part is mainly erythema pimple and has rough and scaly surface, the low-concentration cantharidin is adopted as a foaming agent, and the cutin removing and inflammation diminishing properties of salicylic acid are taken as auxiliary materials, so that thick scabs can be fully removed, and itching and swelling can be well relieved.
The used medicine has good effects of inhibiting and removing skin erythema and pimple, relieving itching, diminishing inflammation, removing blood stasis and detoxifying, and the medicines are combined to directly reach the pathological change part, thereby fully playing the curative effect.
Example 11
A traditional Chinese medicine composition tincture for treating chronic eczema comprises the following raw materials in parts by weight:
50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rhubarb, 20g of raw pinellia ternate and 20g of natural indigo
2g of cantharis, 20g of borneol, 20g of salicylic acid, 20g of 75 percent ethanol and 1000ml of ethanol,
a method for preparing a Chinese medicinal tincture for treating chronic eczema comprises pulverizing radix Euphorbiae Fischerianae 50g, radix Sophorae Flavescentis 50g, radix et rhizoma Rhei 20g, rhizoma Pinelliae 20g, indigo naturalis 20g, and Mylabris 2g, sieving with 100 mesh sieve, adding Borneolum Syntheticum 20g and salicylic acid 20g, soaking in 1000ml 75% ethanol for 7 days, stirring for several times, filtering, and packaging in glass bottles.
Example 12
A Chinese medicinal tincture for treating chronic eczema comprises:
50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rhubarb, 20g of raw pinellia ternate, 20g of natural indigo
Borneol 20g cantharis 2g salicylic acid 20g 75% ethanol 1000ml
A Chinese medicinal tincture for treating chronic eczema is prepared by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, and Mylabris, adding Borneolum Syntheticum and salicylic acid, adding 1000ml of 75% ethanol (with condenser at the upper end of round bottom flask), heating at 50 deg.C for 7 days, stirring for several times, filtering, and packaging in glass bottles.
Example 13
A Chinese medicinal tincture for treating chronic eczema comprises:
100g of radix euphorbiae lantu, 100g of radix sophorae flavescentis, 40g of raw rhubarb, 40g of raw pinellia tuber, 40g of natural indigo
Borneol 40g cantharis 4g salicylic acid 40g 75% ethanol 1000ml
The method for preparing the tincture of the traditional Chinese medicine composition for treating chronic eczema comprises the following steps: pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, and Mylabris, adding Borneolum and salicylic acid, adding into 1000ml round-bottom flask with 75% ethanol, reflux-extracting at 78 deg.C for 72 hr, vacuum-filtering, and packaging in glass bottle.
Comparing the clinical effects with the examples 9-11, the example 9 is better than the examples 10 and 11, the example 9 is the best example, and the tincture is prepared by the process of the example 9.
Example 14
A traditional Chinese medicine composition tincture for treating chronic eczema comprises the following raw material medicines: radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, Borneolum Syntheticum, Mylabris, salicylic acid, caulis Hederae sinensis, Kochiae fructus, Saviae Miltiorrhizae radix, radix Angelicae sinensis, flos Hibisci, fructus Citri Sarcodactylis, Aloe, herba Rosmarini officinalis, folium Artemisiae Argyi, Bulbus Lilii, and 75% ethanol.
The ivy has the effects of resisting bacteria, removing toxicity, removing deposited toxins, and having high transdermal absorption rate, and the whole ivy can be used as a medicine, has the effects of dispelling wind-damp, promoting blood circulation and relieving swelling, and has the treatment effects on traumatic injury, lumbocrural pain, rheumatic arthritis and other diseases. The functional indications are as follows: dispel wind, promote diuresis, activate blood, relieve swelling, pacify liver, and remove toxicity.
Kochiae fructus, dispelling pathogenic wind and relieving itching, treating eczema, neurodermatitis, etc., and inhibiting dermatophyte. For carbuncle, recorded in the selection of new Chinese herbal medicine therapy data: broom cypress fruit and Laiyao Zi are respectively one or two. Decocting with slow fire, and washing the affected part while hot for 10-15 min 2 times a day.
Dan Shen has the actions of resisting bacteria, astringing, healing the epidermis and removing scars, and is recorded in the book Yu Fang (elbow and back) for treating the heat, oil and fire burning, removing pain and promoting granulation, and is finely adjusted with water, two jin of mutton tallow is taken, three upper and three lower portions are decocted, and the sore is smeared. The total tanshinone of Saviae Miltiorrhizae radix has inhibitory effect on Staphylococcus aureus and its drug-resistant strain; the external use of the salvia miltiorrhiza injection has the functions of promoting wound healing and intestinal anastomosis healing; tanshinone A has effect in inducing tumor cell differentiation; salvianic acid A has the function of inhibiting fibroblast proliferation in vitro.
Dang Gui, for resolving abscess and dissipating swelling, is decocted to have antibacterial action.
The erigeron breviscapus has the effects of promoting blood circulation, activating skin cells, dispelling cold, relieving exterior syndrome, dispelling wind, removing dampness, promoting blood circulation, relaxing muscles and tendons, promoting digestion, relieving pain and the like.
The bergamot has special effects on acne, eczema and ulcer, can improve long-term itching and dryness, and is helpful for relieving inflammation and killing skin infection.
Aloe, improve rough skin, tranquilize and resist inflammation, the mucus (protein) in Aloe is core ingredient of polysaccharides such as arboran A Baloe mannanase, etc., and the mucus material is important ingredient for preventing cell aging and treating chronic allergy; the aloe can promote healing, has the effect of promoting healing of aloe on the back of an artificial wound mouse, and can shorten the healing days for the aloe in an artificial conjunctival edema rabbit. The aloe juice preparation has protective effect on skin wound, burn and x-ray local irradiation; the aloin A, wound hormone and polypeptide mannan (Ke-2) have functions of resisting virus infection, promoting wound healing and recovery, diminishing inflammation, killing bacteria, absorbing heat, relieving swelling, softening skin, and maintaining cell activity, and the combination of curdlan and wound healing activity.
Rosemary, which activates cells, promotes blood circulation, and stimulates hair regeneration.
The folium artemisiae argyi is externally used for eliminating dampness, relieving itching and inhibiting skin bacteria and mite regeneration.
Lily root, radix Lilii, for increasing skin elasticity, it is good to be pounded into paste in Yebai, for treating swelling and sore on the side of the treatment in Bao Hui Zheng Yan Fang (prescription of Hui Zheng). For craniocerebral ulcer, it is recorded in Shengjie Zong Lu (holy book of treatises), Baihe, Huangbai, Bai Ji, and Ricinus seed, fifty grains (ground). The powder is prepared by mixing sodium sulfate and water as cake paste, and is applied on more than three days; for eczema and eczema, it is smashed and applied on Lily in Bin Hu Ji Jian Fang (Collection of simple prescription from Bin lake).
A method for preparing Chinese medicinal tincture for treating chronic eczema comprises pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, Mylabris, Borneolum Syntheticum, caulis Hederae sinensis, Kochiae fructus, Saviae Miltiorrhizae radix, radix Angelicae sinensis, flos Hibisci, fructus Citri Sarcodactylis, Aloe, herba Rosmarini officinalis, folium Artemisiae Argyi and Bulbus Lilii, adding Borneolum Syntheticum and salicylic acid, mixing, adding 1000ml 75% ethanol, soaking for 7 days, stirring for several times, filtering, and packaging in glass bottles. The preparation is simple and easy to realize.
Example 15
A traditional Chinese medicine composition tincture for treating chronic eczema comprises the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis, 1-3 parts of cantharis, 18-22 parts of borneol, 18-22 parts of salicylic acid, 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily, and 1100 parts of 75% ethanol 900-.
Clinical comparative data prove that the proportioning setting is reasonable.
A method for preparing a traditional Chinese medicine composition tincture for treating chronic eczema comprises the steps of crushing 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rheum officinale, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis, 1-3 parts of cantharis, 1-3 parts of borneol, 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica sinensis, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily, adding borneol and salicylic acid, uniformly mixing, putting all the materials into 1000 parts of 75% ethanol, soaking for 7 days, stirring for multiple times in the middle period, carrying out suction filtration, and subpackaging in. The preparation is simple and easy to realize.
Example 16
A traditional Chinese medicine composition for treating chronic eczema comprises the following raw material medicines in parts by mass: 50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rhubarb, 20g of raw pinellia ternate, 20g of indigo naturalis, 2g of cantharis, 20g of borneol, 20g of salicylic acid, 1g of ivy, 1g of fructus kochiae, 1g of salvia miltiorrhiza, 1g of angelica sinensis, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe and 1g of rosemary.
A traditional Chinese medicine composition tincture for treating chronic eczema comprises the following raw material medicines in parts by mass: 50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rhubarb, 20g of raw pinellia ternate, 20g of indigo naturalis, 2g of cantharis, 20g of borneol, 20g of salicylic acid, 1g of ivy, 1g of fructus kochiae, 1g of salvia miltiorrhiza, 1g of angelica sinensis, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe, 1g of rosemary and 1000ml of 75% ethanol.
A method for preparing a traditional Chinese medicine composition tincture for treating chronic eczema comprises the steps of crushing 50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rhubarb, 20g of raw pinellia ternate, 20g of indigo naturalis, 2g of cantharis, 1g of ivy, 1g of fructus kochiae, 1g of radix salviae miltiorrhizae, 1g of angelica, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe and 1g of rosemary, adding 20g of borneol and 20g of salicylic acid, uniformly mixing, completely putting into 1000ml of 75% ethanol, soaking for 7 days, stirring for multiple times in the middle, carrying out suction filtration, and subpackaging in glass bottles for later use, thus. The preparation is simple and easy to realize.
Example 17
The use method of the traditional Chinese medicine composition tincture for treating chronic eczema comprises the following steps:
the medicine is applied to the affected part with cotton swab three times a day.
Clinical observations
1 clinical data
1.1 general data
On the premise of informed consent, 90 chronic eczema patients, 51 men and 39 women, meeting the Tuna standard and the exclusion standard in the XX hospital during the 9 th month in 2018 to the 12 th month in 2019 are selected; ages 25-75 years, mean (43.26 shi 6.17) years. The Chinese herbal medicines are numbered in turn according to the sequence of the people's houses and are randomly divided into three groups of 30 cases. The general data of each group, namely sex, age, course of disease and difference of score of major symptoms, have no statistical significance P >0.05) and are comparable.
1.2 methods
The first treatment group: the traditional Chinese medicine formula tincture (a traditional Chinese medicine composition tincture for treating chronic eczema) is used for treating eczema, and the tincture is externally applied to an affected part and is applied once in the morning, at noon and at night for 4 weeks continuously, wherein the tincture comprises the following raw material medicines, by mass, 50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rheum officinale, 20g of raw pinellia ternate, 20g of indigo naturalis, 2g of cantharis, 20g of borneol, 20g of salicylic acid and 1000ml of 75% ethanol.
The second treatment group: the traditional Chinese medicine formula tincture (a traditional Chinese medicine composition tincture for treating chronic eczema) is used for treating, and is externally applied to an affected part for 4 weeks, wherein the tincture is prepared from the following raw materials, by mass, 50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rheum officinale, 20g of raw pinellia ternate, 20g of indigo naturalis, 2g of cantharis, 20g of borneol, 20g of salicylic acid, 1g of ivy, 1g of fructus kochiae, 1g of salvia miltiorrhiza, 1g of angelica sinensis, 1g of erigeron breviscapus, 1g of bergamot, 1g of aloe, 1g of rosemary and 1000ml of 75% ethanol.
The control group is flufenamic acid butyl ester ointment (Shanghai combined pharmacy limited, Chinese medicine Standard H20163106) for treatment, which is applied to affected part once in the morning, in the middle of the morning and at night for 4 weeks, and can enhance disease management and protect skin from sunburn.
Three groups of patients were cured and followed for 3 months and observed for relapse rates.
3 analysis of therapeutic effects
3.1 Observation index
The main symptoms and signs before, during and after 2 weeks of withdrawal of the drug are observed, including itching, erythema, pimple, water scar, erosion, exudation, keratosis and rhagadia, and are classified according to 0-3 grades and classified into none, light, medium and heavy. 0 min to 4 min. ② the cure rate, the total effective rate and the adverse reaction of each group of patients after stopping taking the medicine for 2 weeks are compared. And thirdly, comparing the healing time of the skin lesion, the disappearance time of symptoms and the 3-month recurrence rate of the patients.
3.2 therapeutic criteria
Integral reduction index (%) — (total integral of pre-treatment cardinal signs-total score of post-treatment cardinal signs)/total integral of pre-treatment cardinal signs x 100%. The total effective rate is curing, obvious effect and improvement.
Curing, namely completely eliminating skin damage and pruritus;
the effect is obvious, the rash and the pruritus basically disappear, and the integral reduction index is more than 60 percent;
the improvement is that the rash and the pruritus are relieved, and the integral reduction index is more than or equal to 30 percent and less than 60 percent;
the skin rash and pruritus are not relieved or even aggravated, and the integral drop index is less than 30%.
3.3 statistical methods
Processing with SPSS 18.0, testing with t test, and counting with x + -s2Inspection, P<A difference of 0.05 is statistically significant.
3.4 therapeutic results
All 90 patients in the group are successfully tested and treated, and no obvious adverse reaction occurs in three groups of patients. 3.4.1 the cure rate and total effective rate of three groups of patients after stopping taking the medicine for 2 weeks are compared (see Table 1)
The results show that the cure rates of the first treatment group, the second treatment group and the control group are respectively 66.67%, 70.00% and 50.00%, the total effective rates are respectively 100%, 100% and 83.33%, and the clinical curative effects of the first treatment group and the second treatment group are better than those of the control group. However, the difference between the first treatment group and the second treatment group was not statistically significant. The clinical efficacy of the first treatment group and the second treatment group was superior to that of the control group, but the difference between the A treatment group and the second treatment group was not statistically significant.
Table 1 three groups of comparative examples of clinical efficacy (%)
Figure BDA0002791349800000221
3.4.2 comparison of eczema healing time, symptom disappearance time and follow-up 3 months recurrence rate of each group of patients (see Table 2)
The healing time, symptom disappearance time and recurrence rate of the patients cured by the first treatment group and the second treatment group are respectively lower than those of the control group, the differences have statistical significance (P is less than 0.05), and the differences between the first treatment group and the second treatment group by the soil indexes have no statistical significance. The three groups of relapsing patients still have effective treatment by simply using traditional Chinese medicine external washing, while the traditional Chinese medicine treatment curative effect of the first treatment group and the second treatment group of relapsing patients is obviously better than that of a control group, but the re-grouping contrast study cannot be carried out because the total sample amount of the relapsing patients is less.
TABLE 2 comparison of healing time, symptom disappearance time and follow-up 3 month recurrence rate
Figure BDA0002791349800000222
At present, the western medicines still have a plurality of defects in the aspect of antifungal treatment, and researches show that the traditional Chinese medicine has unique curative effects in the aspect of chronic eczema, no matter the traditional Chinese medicine is a single medicine, the effective components of the traditional Chinese medicine, or a compound preparation. The treatment method comprises external treatment, internal treatment and combination treatment, and the simple external treatment is suitable for patients with initial onset and limited focus.
The data show that the traditional Chinese medicine formula tincture of the first treatment group (a traditional Chinese medicine composition tincture for treating chronic eczema, which comprises the following bulk drugs, by mass, 50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rhubarb, 20g of raw pinellia ternate, 20g of indigo naturalis, 2g of cantharis, 20g of borneol, 20g of salicylic acid and 1000ml of 75% ethanol), and the traditional Chinese medicine formula tincture of the second treatment group (a traditional Chinese medicine composition tincture for treating chronic eczema, which comprises the bulk drugs, by mass, 50g of radix euphorbiae lantu, 50g of radix sophorae flavescentis, 20g of raw rhubarb, 20g of raw pinellia ternate, 20g of indigo naturalis, 2g of cantharis, 20g of borneol, 20g of salicylic acid, 1g of ivy, 1g of fructus kochiae, 1g of radix salviae miltiorrhizae, 1g of angelica sinensis, 1g of erigeron breviscapus, 1g of citrus chirocarpus, 1g of aloe, effective and low recurrence rate. The external washing prescription used in the test can effectively improve the symptoms of the chronic eczema patients; in the traditional Chinese medicine formula, the Chinese wolfsbane root with the functions of resolving masses and resisting bacteria, the lightyellow sophora root with the bitter taste and cold nature and capable of killing parasites and relieving itching, the raw rhubarb with the functions of purging fire, cooling blood, removing stasis and detoxifying, the natural indigo with cold nature and flavor and capable of eliminating sore swelling, erysipelas and macula and the raw pinellia tuber are adopted. Considering that the skin of an affected part is mainly erythematous papule and has rough and scale-covering surfaces, the cantharidin with low concentration is adopted as a foaming agent, and the cutin removing and inflammation diminishing characteristics of salicylic acid are taken as auxiliary materials, so that thick scabs can be fully removed, and itching relieving and swelling diminishing can be better realized. The used medicine has good effects of inhibiting and removing skin erythema and pimple, relieving itching, diminishing inflammation, removing blood stasis and detoxifying, and the medicines are combined to directly reach the pathological change part, thereby fully playing the curative effect.
The embodiments of the present invention have been described in detail, but the present invention is only the preferred embodiments of the present invention, and is not to be considered as limiting the scope of the present invention. All equivalent changes and modifications made within the scope of the present invention shall fall within the scope of the present invention.

Claims (10)

1. A traditional Chinese medicine composition for treating chronic eczema is characterized by comprising the following raw material medicines: radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, Borneolum Syntheticum, Mylabris, and salicylic acid.
2. The traditional Chinese medicine composition for treating chronic eczema as claimed in claim 2, is characterized by comprising the following raw material medicines in parts by mass: 47-53 parts of radix euphorbiae lantu, 47-53 parts of radix sophorae flavescentis, 18-22 parts of raw rhubarb, 18-22 parts of raw pinellia ternate, 18-22 parts of indigo naturalis, 18-22 parts of borneol, 1-3 parts of cantharis and 18-22 parts of salicylic acid.
3. The traditional Chinese medicine composition for treating chronic eczema as claimed in claim 3, is characterized by comprising the following raw material medicines in parts by mass: 50 parts of radix euphorbiae lantu, 50 parts of radix sophorae flavescentis, 20 parts of raw rhubarb, 20 parts of raw pinellia ternate, 20 parts of indigo naturalis, 20 parts of borneol, 2 parts of cantharis and 20 parts of salicylic acid.
4. The traditional Chinese medicine composition for treating chronic eczema as claimed in claim 2 or 3, which is characterized by further comprising one or more of hedera helix, fructus kochiae, salvia miltiorrhiza, angelica sinensis, erigeron breviscapus, bergamot, aloe, rosemary, folium artemisiae argyi and lily.
5. The traditional Chinese medicine composition for treating chronic eczema as claimed in claim 4, is characterized by further comprising the following raw material medicines in parts by mass: 1-4 parts of ivy, 1-4 parts of fructus kochiae, 1-4 parts of salvia miltiorrhiza, 1-4 parts of angelica, 1-4 parts of erigeron breviscapus, 1-4 parts of bergamot, 1-4 parts of aloe, 1-4 parts of rosemary, 1-4 parts of folium artemisiae argyi and 1-4 parts of lily.
6. The traditional Chinese medicine composition for treating chronic eczema as claimed in any one of claims 1 to 5, wherein the traditional Chinese medicine composition is in the form of tincture, ointment, plaster, gel or patch.
7. Use of the traditional Chinese medicine composition for treating chronic eczema as claimed in any one of claims 1 to 5 in preparation of medicines for treating chronic eczema, dermatitis or keratoderma.
8. A tincture containing a Chinese medicinal composition for treating chronic eczema as claimed in claim 6, characterised in that it further comprises 75% ethanol.
9. The method for preparing the traditional Chinese medicine composition for treating chronic eczema as claimed in claims 1-5, is characterized in that radix euphorbiae lantu, radix sophorae flavescentis, raw rhubarb, raw pinellia ternate, indigo naturalis and cantharis are crushed, then borneol and salicylic acid are added, and the preparation is completed after even mixing.
10. The method for preparing the tincture of a Chinese medicinal composition for treating chronic eczema as claimed in claim 8, wherein the preparation is completed by pulverizing radix Euphorbiae Fischerianae, radix Sophorae Flavescentis, radix et rhizoma Rhei, rhizoma Pinelliae, indigo naturalis, and Mylabris, adding Borneolum Syntheticum and salicylic acid, soaking in 1100ml 75% ethanol for 6-9 days, stirring for several times, filtering, and packaging in glass bottles.
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Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157734A (en) * 1996-08-21 1997-08-27 姚明佐 Medicine for burn wound ulcer recovery
CN103040926A (en) * 2011-10-11 2013-04-17 涂波 Multi-purpose anti-itch cream
CN108653479A (en) * 2018-06-06 2018-10-16 彭玉伟 A kind of Chinese medicine composition and the preparation method and application thereof for treating refractory skin
CN110721223A (en) * 2019-11-15 2020-01-24 李齐鸣 Itching relieving ointment

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1157734A (en) * 1996-08-21 1997-08-27 姚明佐 Medicine for burn wound ulcer recovery
CN103040926A (en) * 2011-10-11 2013-04-17 涂波 Multi-purpose anti-itch cream
CN108653479A (en) * 2018-06-06 2018-10-16 彭玉伟 A kind of Chinese medicine composition and the preparation method and application thereof for treating refractory skin
CN110721223A (en) * 2019-11-15 2020-01-24 李齐鸣 Itching relieving ointment

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