CN114846137A - 一种亲和填料及其制备方法和应用 - Google Patents
一种亲和填料及其制备方法和应用 Download PDFInfo
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- CN114846137A CN114846137A CN201980103155.9A CN201980103155A CN114846137A CN 114846137 A CN114846137 A CN 114846137A CN 201980103155 A CN201980103155 A CN 201980103155A CN 114846137 A CN114846137 A CN 114846137A
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- Peptides Or Proteins (AREA)
Abstract
一种亲和填料及其制备方法和应用，所述亲和填料为与乙酰肝素酶结合域多肽偶联的基质，所述乙酰肝素酶结合域多肽经活性中心保护剂处理。通过在基质上偶联乙酰肝素酶结合域多肽得到亲和填料，使用该亲和填料可从肝素中分离得到更高乙酰肝素酶抑制活性的组分，该组分的抑制活性相比肝素提高约10倍，可用于抗肿瘤药物的开发，具有广阔的应用前景。
Description
PCT国内申请，说明书已公开。
Claims (15)
- PCT国内申请，权利要求书已公开。
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- 2019-12-27 WO PCT/CN2019/129112 patent/WO2021128255A1/zh active Application Filing
- 2019-12-27 CN CN201980103155.9A patent/CN114846137B/zh active Active
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| WO2021128255A1 (zh) | 2021-07-01 |
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