CN114828844A - 用lsd1抑制剂治疗lsd1相关疾病和病症的方法 - Google Patents

用lsd1抑制剂治疗lsd1相关疾病和病症的方法 Download PDF

Info

Publication number
CN114828844A
CN114828844A CN202080079021.0A CN202080079021A CN114828844A CN 114828844 A CN114828844 A CN 114828844A CN 202080079021 A CN202080079021 A CN 202080079021A CN 114828844 A CN114828844 A CN 114828844A
Authority
CN
China
Prior art keywords
fluoro
week
salt
aminopyrrolidine
benzonitrile
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CN202080079021.0A
Other languages
English (en)
Chinese (zh)
Inventor
一町裕子
町田卓充
山田真生
H·基尔
A·奥加内西安
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Taiho Pharmaceutical Co Ltd
Astex Pharmaceuticals Inc
Original Assignee
Taiho Pharmaceutical Co Ltd
Astex Pharmaceuticals Inc
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Taiho Pharmaceutical Co Ltd, Astex Pharmaceuticals Inc filed Critical Taiho Pharmaceutical Co Ltd
Publication of CN114828844A publication Critical patent/CN114828844A/zh
Pending legal-status Critical Current

Links

Images

Classifications

    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/185—Acids; Anhydrides, halides or salts thereof, e.g. sulfur acids, imidic, hydrazonic or hydroximic acids
    • A61K31/19—Carboxylic acids, e.g. valproic acid
    • A61K31/20—Carboxylic acids, e.g. valproic acid having a carboxyl group bound to a chain of seven or more carbon atoms, e.g. stearic, palmitic, arachidic acids
    • A61K31/203—Retinoic acids ; Salts thereof
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
    • C07C63/00—Compounds having carboxyl groups bound to a carbon atoms of six-membered aromatic rings
    • C07C63/04—Monocyclic monocarboxylic acids
    • C07C63/06—Benzoic acid
    • C07C63/08—Salts thereof
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D207/00—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom
    • C07D207/02—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D207/10—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
    • C07D207/14—Nitrogen atoms not forming part of a nitro radical
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2300/00—Mixtures or combinations of active ingredients, wherein at least one active ingredient is fully defined in groups A61K31/00 - A61K41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07B—GENERAL METHODS OF ORGANIC CHEMISTRY; APPARATUS THEREFOR
    • C07B2200/00—Indexing scheme relating to specific properties of organic compounds
    • C07B2200/13—Crystalline forms, e.g. polymorphs

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Oncology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
  • Pyrrole Compounds (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
CN202080079021.0A 2019-11-13 2020-11-13 用lsd1抑制剂治疗lsd1相关疾病和病症的方法 Pending CN114828844A (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962934923P 2019-11-13 2019-11-13
US62/934,923 2019-11-13
PCT/JP2020/042410 WO2021095840A1 (en) 2019-11-13 2020-11-13 METHODS OF TREATING LSD1-RELATED DISEASES and Disorders WITH LSD1 INHIBITORS

Publications (1)

Publication Number Publication Date
CN114828844A true CN114828844A (zh) 2022-07-29

Family

ID=75912767

Family Applications (2)

Application Number Title Priority Date Filing Date
CN202080079021.0A Pending CN114828844A (zh) 2019-11-13 2020-11-13 用lsd1抑制剂治疗lsd1相关疾病和病症的方法
CN202080078991.9A Active CN114728899B (zh) 2019-11-13 2020-11-13 新型三苯基化合物盐

Family Applications After (1)

Application Number Title Priority Date Filing Date
CN202080078991.9A Active CN114728899B (zh) 2019-11-13 2020-11-13 新型三苯基化合物盐

Country Status (18)

Country Link
US (2) US12419858B2 (https=)
EP (2) EP4058151B1 (https=)
JP (2) JP7492002B2 (https=)
KR (2) KR102825246B1 (https=)
CN (2) CN114828844A (https=)
AU (2) AU2020382379B2 (https=)
BR (2) BR112022009221A2 (https=)
CA (2) CA3157404A1 (https=)
DK (1) DK4058151T3 (https=)
ES (1) ES3034158T3 (https=)
FI (1) FI4058151T3 (https=)
HU (1) HUE072206T2 (https=)
MX (2) MX2022005811A (https=)
PH (2) PH12022551169A1 (https=)
PL (1) PL4058151T3 (https=)
PT (1) PT4058151T (https=)
TW (2) TWI874489B (https=)
WO (2) WO2021095835A1 (https=)

Families Citing this family (24)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
AU2018276611B2 (en) 2017-05-31 2022-01-06 Taiho Pharmaceutical Co., Ltd. Method for predicting therapeutic effect of LSD1 inhibitor based on expression of INSM1
WO2021095835A1 (en) 2019-11-13 2021-05-20 Taiho Pharmaceutical Co., Ltd. Novel salt of terphenyl compound
US20250073232A1 (en) 2021-04-08 2025-03-06 Oryzon Genomics, S.A. Combinations of lsd1 inhibitors for treating myeloid cancers
EP4337638A1 (en) * 2021-05-11 2024-03-20 Astex Pharmaceuticals, Inc. Solid forms of salts of 4-[5-[(3s)-3-aminopyrrolidine-1-carbonyl]-2-[2-fluoro-4-(2-hydroxy-2-ethylpropyl)phenyl]phenyl]-2-fluoro-benzonitrile
US20250049757A1 (en) * 2021-09-30 2025-02-13 Taiho Pharmaceutical Co. Ltd. Combinatory therapy for cancer using biphenyl compound and immune checkpoint molecule regulator
JP7788550B2 (ja) * 2021-10-26 2025-12-18 大鵬薬品工業株式会社 ターフェニル化合物の安息香酸塩の製造方法
US20250295660A1 (en) 2022-05-09 2025-09-25 Oryzon Genomics, S.A. Methods of treating nf1-mutant tumors using lsd1 inhibitors
EP4522136A1 (en) 2022-05-09 2025-03-19 Oryzon Genomics, S.A. Methods of treating malignant peripheral nerve sheath tumor (mpnst) using lsd1 inhibitors
CN120529900A (zh) 2022-11-24 2025-08-22 奥莱松基因组股份有限公司 用于治疗癌症的LSD1抑制剂和Menin抑制剂的组合
WO2024229073A1 (en) * 2023-05-02 2024-11-07 Otsuka Pharmaceutical Co., Ltd. Response-based dosing for treating cancer with a hypomethylating agent and cedazuridine
TW202508595A (zh) 2023-05-04 2025-03-01 美商銳新醫藥公司 用於ｒａｓ相關疾病或病症之組合療法
US20250049810A1 (en) 2023-08-07 2025-02-13 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
AU2024360465A1 (en) 2023-10-12 2026-04-09 Revolution Medicines, Inc. Macrocyclic ras inhibitors
WO2025171296A1 (en) 2024-02-09 2025-08-14 Revolution Medicines, Inc. Ras inhibitors
TW202547461A (zh) 2024-05-17 2025-12-16 美商銳新醫藥公司 Ｒａｓ抑制劑
WO2025255438A1 (en) 2024-06-07 2025-12-11 Revolution Medicines, Inc. Methods of treating a ras protein-related disease or disorder
WO2025265060A1 (en) 2024-06-21 2025-12-26 Revolution Medicines, Inc. Therapeutic compositions and methods for managing treatment-related effects
WO2026006747A1 (en) 2024-06-28 2026-01-02 Revolution Medicines, Inc. Ras inhibitors
WO2026015790A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015801A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015796A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Methods of treating a ras related disease or disorder
WO2026015825A1 (en) 2024-07-12 2026-01-15 Revolution Medicines, Inc. Use of ras inhibitor for treating pancreatic cancer
WO2026050446A1 (en) 2024-08-29 2026-03-05 Revolution Medicines, Inc. Ras inhibitors
WO2026072904A2 (en) 2024-09-26 2026-04-02 Revolution Medicines, Inc. Compositions and methods for treating lung cancer

Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602770A (zh) * 2015-11-27 2018-09-28 大鹏药品工业株式会社 新型联苯化合物或其盐
WO2018216795A1 (ja) * 2017-05-26 2018-11-29 大鵬薬品工業株式会社 新規なビフェニル化合物を用いた抗腫瘍効果増強剤
WO2018216800A1 (ja) * 2017-05-26 2018-11-29 大鵬薬品工業株式会社 新規なビフェニル化合物又はその塩
WO2018221555A1 (ja) * 2017-05-31 2018-12-06 大鵬薬品工業株式会社 Ｉｎｓｍ１の発現に基づくｌｓｄ１阻害剤の治療効果の予測方法

Family Cites Families (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
SE8801518D0 (sv) * 1988-04-22 1988-04-22 Astra Pharma Prod A novel process
US6225049B1 (en) 1992-06-17 2001-05-01 The United States Of America As Represented By The Department Of Health And Human Services Human insulinoma-associated cDNA
CA2469649C (en) 2001-12-13 2011-05-03 Natrogen Therapeutics, Inc. Derivatives of isoindigo, indigo and indirubin and use in treating cancer
AU2003281200A1 (en) 2002-07-03 2004-01-23 Tasuku Honjo Immunopotentiating compositions
EP1792622A1 (en) 2005-11-11 2007-06-06 GPC Biotech AG Anti-proliferative combination therapy comprising a platinum-based chemotherapeutic agent and EGFR inhibitors or pyrimidine analogues
JP2011530511A (ja) 2008-08-05 2011-12-22 メルク・シャープ・エンド・ドーム・コーポレイション 治療用化合物
EP2350317A4 (en) 2008-10-20 2012-06-27 Univ Colorado Regents BIOLOGICAL MARKERS FOR PREDICTING THE ANTICIPATE RESPONSE TO INSULINARY GROWTH FACTOR 1 RECEPTOR KINASE INHIBITORS
US8367679B2 (en) 2008-12-09 2013-02-05 Merck Sharp & Dohme Corp. Biaryl carboxamides
EP2419177A1 (en) 2009-04-17 2012-02-22 OSI Pharmaceuticals, LLC Biological markers predictive of anti-cancer response to epidermal growth factor receptor kinase inhibitors
BR112012027062B8 (pt) 2010-04-20 2021-05-25 Fond Ieo composto, processo para a preparação de um composto e usos do mesmo
BR112013002164B1 (pt) 2010-07-29 2021-11-09 Oryzon Genomics S.A. Inibidores de desmetilase à base de arilciclopropilamina de lsd1, seus usos, e composição farmacêutica
WO2012157647A1 (ja) 2011-05-16 2012-11-22 大鵬薬品工業株式会社 胃癌患者に対するテガフール・ギメラシル・オテラシルカリウム配合剤及びｅｇｆｒ阻害剤からなる化学療法の選択方法
EP2768805B1 (en) 2011-10-20 2020-03-25 Oryzon Genomics, S.A. (hetero)aryl cyclopropylamine compounds as lsd1 inhibitors
CN104411316B (zh) * 2012-05-09 2018-05-01 坎泰克斯制药股份有限公司 骨髓抑制的治疗
US9834521B2 (en) 2013-03-15 2017-12-05 Ariad Pharmaceuticals, Inc. Choline kinase inhibitors
ES2734209T3 (es) 2013-08-06 2019-12-04 Imago Biosciences Inc Inhibidores de KDM1A para el tratamiento de enfermedades
US9266907B2 (en) 2013-09-05 2016-02-23 King Abdullah University Of Science And Technology Tunable rare-earth fcu-metal-organic frameworks
CA3161836A1 (en) 2013-12-11 2015-06-18 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
CN106061969B (zh) 2014-01-06 2019-10-29 阿尔戈么迪克斯有限公司 Trpa1调节剂
KR102400920B1 (ko) 2014-05-01 2022-05-20 셀젠 콴티셀 리서치, 인크. 리신 특이적 데메틸라제-1의 억제제
US9758523B2 (en) 2014-07-10 2017-09-12 Incyte Corporation Triazolopyridines and triazolopyrazines as LSD1 inhibitors
CA2958704A1 (en) 2014-08-25 2016-03-03 University Of Canberra Compositions for modulating cancer stem cells and uses therefor
AU2015311805B2 (en) 2014-09-05 2020-04-02 Celgene Quanticel Research, Inc. Inhibitors of lysine specific demethylase-1
EP3285809B1 (en) 2015-04-20 2019-09-11 eFFECTOR Therapeutics, Inc. Inhibitors of immune checkpoint modulators for use in treating cancer and infections
WO2017013061A1 (en) 2015-07-17 2017-01-26 Oryzon Genomics, S.A. Biomarkers associated with lsd1 inhibitors and uses thereof
WO2018136961A1 (en) 2017-01-23 2018-07-26 Syros Pharmaceuticals Inc. METHODS OF TREATING PATIENTS WITH A RETINOIC ACID RECEPTOR-α AGONIST AND AN ANTI-CD38 ANTIBODY
KR20200020899A (ko) 2017-06-30 2020-02-26 셀진 코포레이션 2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일)메틸)-2,2-디플루오로아세트아미드의 조성물 및 사용 방법
WO2019075327A1 (en) 2017-10-12 2019-04-18 Dana-Farber Cancer Institute, Inc. TREATMENT OF MERKEL CELL CARCINOMA
WO2019083971A1 (en) 2017-10-23 2019-05-02 Children's Medical Center Corporation METHODS OF TREATING CANCER USING LSD1 INHIBITORS IN COMBINATION WITH IMMUNOTHERAPY
AU2018377852B2 (en) 2017-11-29 2022-03-24 Epiaxis Therapeutics Pty Ltd Enhancing T-cell function and treating a T-cell dysfunctional disorder with a combination of an LSD inhibitor and a PD1 binding antagonist
KR20200105662A (ko) 2018-01-02 2020-09-08 셀진 코포레이션 2-(4-클로로페닐)-n-((2-(2,6-디옥소피페리딘-3-일)-1-옥소이소인돌린-5-일)메틸)-2,2-디플루오로아세트아미드의 동위 이성질체
IL289453B2 (en) 2019-07-17 2026-03-01 Summit Oxford Ltd Process for preparing ridinilazole and its crystalline forms
WO2021095835A1 (en) 2019-11-13 2021-05-20 Taiho Pharmaceutical Co., Ltd. Novel salt of terphenyl compound
EP4114398A1 (en) 2020-03-06 2023-01-11 Celgene Quanticel Research, Inc. Combination of an lsd-1 inhibitor and nivolumab for use in treating sclc or sqnsclc

Patent Citations (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN108602770A (zh) * 2015-11-27 2018-09-28 大鹏药品工业株式会社 新型联苯化合物或其盐
WO2018216795A1 (ja) * 2017-05-26 2018-11-29 大鵬薬品工業株式会社 新規なビフェニル化合物を用いた抗腫瘍効果増強剤
WO2018216800A1 (ja) * 2017-05-26 2018-11-29 大鵬薬品工業株式会社 新規なビフェニル化合物又はその塩
WO2018221555A1 (ja) * 2017-05-31 2018-12-06 大鵬薬品工業株式会社 Ｉｎｓｍ１の発現に基づくｌｓｄ１阻害剤の治療効果の予測方法

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
A. HOLLEBECQUE等: "Phase I study of CC-90011 in patients with advanced solid tumors and relapsed/refractory non-Hodgkin lymphoma (R/R NHL)", ANNALS OF ONCOLOGY, vol. 29, pages 649 *

Also Published As

Publication number Publication date
TW202128617A (zh) 2021-08-01
KR20220113390A (ko) 2022-08-12
EP4058018A1 (en) 2022-09-21
US12419858B2 (en) 2025-09-23
KR102825246B1 (ko) 2025-06-25
EP4058151B1 (en) 2025-05-21
PL4058151T3 (pl) 2025-08-04
BR112022008020A2 (pt) 2022-07-12
PH12022551137A1 (en) 2023-10-09
KR20220101145A (ko) 2022-07-19
TWI874490B (zh) 2025-03-01
EP4058151A4 (en) 2023-10-25
MX2022005812A (es) 2022-08-16
EP4058151A1 (en) 2022-09-21
CA3158442A1 (en) 2021-05-20
PT4058151T (pt) 2025-06-12
AU2020382214B2 (en) 2023-07-06
US20220411368A1 (en) 2022-12-29
AU2020382379B2 (en) 2024-03-28
AU2020382214A1 (en) 2022-04-21
CA3157404A1 (en) 2021-05-20
US20220387384A1 (en) 2022-12-08
CN114728899A (zh) 2022-07-08
JP2023501627A (ja) 2023-01-18
PH12022551169A1 (en) 2024-02-19
JP7379680B2 (ja) 2023-11-14
JP2022550374A (ja) 2022-12-01
WO2021095840A1 (en) 2021-05-20
MX2022005811A (es) 2022-06-08
ES3034158T3 (en) 2025-08-13
FI4058151T3 (fi) 2025-07-16
CN114728899B (zh) 2023-12-05
JP7492002B2 (ja) 2024-05-28
BR112022009221A2 (pt) 2022-07-26
WO2021095835A1 (en) 2021-05-20
DK4058151T3 (da) 2025-06-30
EP4058018A4 (en) 2023-06-21
TWI874489B (zh) 2025-03-01
AU2020382379A1 (en) 2022-05-05
TW202128616A (zh) 2021-08-01
HUE072206T2 (hu) 2025-10-28

Similar Documents

Publication Publication Date Title
TWI874489B (zh) 利用ｌｓｄ１抑制劑治療ｌｓｄ１相關疾病及病症之方法
TWI334350B (en) Cancer treatment
CN114727996A (zh) 用于治疗白血病或骨髓增生异常综合征的与维奈托克、吉瑞替尼、米哚妥林或其他化合物组合的阿扎胞苷
EP3453392B1 (en) Therapeutic agent for lung cancer that has acquired egfr-tki resistance
US20230398119A1 (en) Combination therapy involving diaryl macrocyclic compounds
DK2799070T3 (en) EFFECTIVE AMPLIFIER FOR ANTITUMUM AGENTS
JP2012515184A (ja) 大腸がんの治療方法
CN102753176B (zh) 含有cdc7抑制剂和抗癌药的治疗组合物
US11524009B2 (en) Combination comprising at least one spliceosome modulator and at least one inhibitor chosen from BCL2 inhibitors, BCL2/BCLxL inhibitors, and BCLxL inhibitors and methods of use
TW201922256A (zh) 治療淋巴樣惡性疾病之方法
JP2024125140A (ja) アズブジンと化学療法剤とを含む抗腫瘍医薬組成物
EP4489756A1 (en) Methods of treating small cell lung cancer
JP6895688B2 (ja) 血液がんの新規治療法及び新規治療剤
HK40078096A (en) Methods of treating lsd1-related diseases and disorders with lsd1 inhibitors
RU2826217C1 (ru) Способы лечения заболеваний и нарушений, связанных с lsd1, ингибиторами lsd1
CN114173779A (zh) 对抗ccr4抗体具有抗性的癌症的治疗剂
RU2519199C2 (ru) Противоопухолевый агент, набор и способ лечения рака
CN116390735A (zh) 治疗癌症的Bcl-2抑制剂和低甲基化剂的组合、其用途和药物组合物
US11179349B2 (en) Use of tumor gene methylation regulator and anti-tumor drugs
JP2014034531A (ja) Ｈｓｐ９０阻害剤とゲムシタビンの組み合わせ
HK40092504A (zh) 治疗癌症的bcl-2抑制剂和低甲基化剂的组合、其用途和药物组合物
CN107802833A (zh) 赫赛汀、依维莫司和长春瑞滨的药物组合
CN101980713A (zh) 含有胞嘧啶核苷衍生物与卡铂的抗肿瘤剂
WO2011152515A1 (ja) インドール化合物を含有する抗腫瘍剤

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
REG Reference to a national code

Ref country code: HK

Ref legal event code: DE

Ref document number: 40078096

Country of ref document: HK

WD01 Invention patent application deemed withdrawn after publication

Application publication date: 20220729

WD01 Invention patent application deemed withdrawn after publication