CN114794131A - Acaricidal composition containing Spidoxamat and spirodiclofen - Google Patents
Acaricidal composition containing Spidoxamat and spirodiclofen Download PDFInfo
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- CN114794131A CN114794131A CN202210559230.6A CN202210559230A CN114794131A CN 114794131 A CN114794131 A CN 114794131A CN 202210559230 A CN202210559230 A CN 202210559230A CN 114794131 A CN114794131 A CN 114794131A
- Authority
- CN
- China
- Prior art keywords
- spirodiclofen
- spidoxamat
- acaricidal composition
- composition according
- acaricidal
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000005664 Spirodiclofen Substances 0.000 title claims abstract description 38
- DTDSAWVUFPGDMX-UHFFFAOYSA-N spirodiclofen Chemical compound CCC(C)(C)C(=O)OC1=C(C=2C(=CC(Cl)=CC=2)Cl)C(=O)OC11CCCCC1 DTDSAWVUFPGDMX-UHFFFAOYSA-N 0.000 title claims abstract description 38
- CMURKFSRGAWINZ-UHFFFAOYSA-N 2-(4-chloro-2,6-dimethylphenyl)-1-hydroxy-9,12-dioxa-4-azadispiro[4.2.4^{8}.2^{5}]tetradec-1-en-3-one Chemical compound CC1=CC(Cl)=CC(C)=C1C(C(N1)=O)=C(O)C11CCC2(OCCO2)CC1 CMURKFSRGAWINZ-UHFFFAOYSA-N 0.000 title claims abstract description 34
- 239000000203 mixture Substances 0.000 title claims abstract description 29
- 230000000895 acaricidal effect Effects 0.000 title claims abstract description 25
- 241000238876 Acari Species 0.000 claims abstract description 22
- 239000000575 pesticide Substances 0.000 claims abstract description 7
- 239000004480 active ingredient Substances 0.000 claims abstract description 5
- 241001454293 Tetranychus urticae Species 0.000 claims description 16
- 241000607479 Yersinia pestis Species 0.000 claims description 10
- 241000344246 Tetranychus cinnabarinus Species 0.000 claims description 5
- 239000004563 wettable powder Substances 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 4
- 239000002671 adjuvant Substances 0.000 claims description 3
- 239000000945 filler Substances 0.000 claims description 3
- 238000009472 formulation Methods 0.000 claims description 2
- 235000012055 fruits and vegetables Nutrition 0.000 claims description 2
- 239000004562 water dispersible granule Substances 0.000 claims description 2
- 230000003129 miticidal effect Effects 0.000 claims 2
- 239000004495 emulsifiable concentrate Substances 0.000 claims 1
- 239000004546 suspension concentrate Substances 0.000 claims 1
- 230000002195 synergetic effect Effects 0.000 abstract description 6
- 206010059866 Drug resistance Diseases 0.000 abstract description 3
- 239000002552 dosage form Substances 0.000 abstract description 3
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 12
- 238000012360 testing method Methods 0.000 description 12
- 239000003814 drug Substances 0.000 description 10
- 239000003795 chemical substances by application Substances 0.000 description 8
- 239000000642 acaricide Substances 0.000 description 7
- 229920005551 calcium lignosulfonate Polymers 0.000 description 6
- 230000000694 effects Effects 0.000 description 5
- 241000722363 Piper Species 0.000 description 4
- DBMJMQXJHONAFJ-UHFFFAOYSA-M Sodium laurylsulphate Chemical compound [Na+].CCCCCCCCCCCCOS([O-])(=O)=O DBMJMQXJHONAFJ-UHFFFAOYSA-M 0.000 description 4
- SNAAJJQQZSMGQD-UHFFFAOYSA-N aluminum magnesium Chemical compound [Mg].[Al] SNAAJJQQZSMGQD-UHFFFAOYSA-N 0.000 description 4
- 239000002518 antifoaming agent Substances 0.000 description 4
- 238000013329 compounding Methods 0.000 description 4
- -1 pH regulators Substances 0.000 description 4
- 229920005646 polycarboxylate Polymers 0.000 description 4
- 231100000419 toxicity Toxicity 0.000 description 4
- 230000001988 toxicity Effects 0.000 description 4
- 239000000230 xanthan gum Substances 0.000 description 4
- 235000010493 xanthan gum Nutrition 0.000 description 4
- 229920001285 xanthan gum Polymers 0.000 description 4
- 229940082509 xanthan gum Drugs 0.000 description 4
- 239000005995 Aluminium silicate Substances 0.000 description 3
- LYCAIKOWRPUZTN-UHFFFAOYSA-N Ethylene glycol Chemical compound OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 3
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 3
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 3
- 230000009471 action Effects 0.000 description 3
- 235000012211 aluminium silicate Nutrition 0.000 description 3
- 239000000440 bentonite Substances 0.000 description 3
- 229910000278 bentonite Inorganic materials 0.000 description 3
- SVPXDRXYRYOSEX-UHFFFAOYSA-N bentoquatam Chemical compound O.O=[Si]=O.O=[Al]O[Al]=O SVPXDRXYRYOSEX-UHFFFAOYSA-N 0.000 description 3
- RYAGRZNBULDMBW-UHFFFAOYSA-L calcium;3-(2-hydroxy-3-methoxyphenyl)-2-[2-methoxy-4-(3-sulfonatopropyl)phenoxy]propane-1-sulfonate Chemical compound [Ca+2].COC1=CC=CC(CC(CS([O-])(=O)=O)OC=2C(=CC(CCCS([O-])(=O)=O)=CC=2)OC)=C1O RYAGRZNBULDMBW-UHFFFAOYSA-L 0.000 description 3
- 239000006229 carbon black Substances 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000008367 deionised water Substances 0.000 description 3
- 229910021641 deionized water Inorganic materials 0.000 description 3
- NLYAJNPCOHFWQQ-UHFFFAOYSA-N kaolin Chemical compound O.O.O=[Al]O[Si](=O)O[Si](=O)O[Al]=O NLYAJNPCOHFWQQ-UHFFFAOYSA-N 0.000 description 3
- 238000002360 preparation method Methods 0.000 description 3
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 3
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 235000016623 Fragaria vesca Nutrition 0.000 description 2
- 240000009088 Fragaria x ananassa Species 0.000 description 2
- 235000011363 Fragaria x ananassa Nutrition 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- NBIIXXVUZAFLBC-UHFFFAOYSA-N Phosphoric acid Chemical compound OP(O)(O)=O NBIIXXVUZAFLBC-UHFFFAOYSA-N 0.000 description 2
- 241001454294 Tetranychus Species 0.000 description 2
- 235000009754 Vitis X bourquina Nutrition 0.000 description 2
- 235000012333 Vitis X labruscana Nutrition 0.000 description 2
- 240000006365 Vitis vinifera Species 0.000 description 2
- 235000014787 Vitis vinifera Nutrition 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 238000003556 assay Methods 0.000 description 2
- KBPLFHHGFOOTCA-UHFFFAOYSA-N caprylic alcohol Natural products CCCCCCCCO KBPLFHHGFOOTCA-UHFFFAOYSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 239000002270 dispersing agent Substances 0.000 description 2
- 235000013601 eggs Nutrition 0.000 description 2
- 231100000053 low toxicity Toxicity 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 239000003090 pesticide formulation Substances 0.000 description 2
- 229940051841 polyoxyethylene ether Drugs 0.000 description 2
- 229920000056 polyoxyethylene ether Polymers 0.000 description 2
- 239000011734 sodium Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 230000004083 survival effect Effects 0.000 description 2
- 239000000375 suspending agent Substances 0.000 description 2
- 238000010998 test method Methods 0.000 description 2
- 239000002562 thickening agent Substances 0.000 description 2
- 238000009736 wetting Methods 0.000 description 2
- XGWIJUOSCAQSSV-XHDPSFHLSA-N (S,S)-hexythiazox Chemical compound S([C@H]([C@@H]1C)C=2C=CC(Cl)=CC=2)C(=O)N1C(=O)NC1CCCCC1 XGWIJUOSCAQSSV-XHDPSFHLSA-N 0.000 description 1
- IXPNQXFRVYWDDI-UHFFFAOYSA-N 1-methyl-2,4-dioxo-1,3-diazinane-5-carboximidamide Chemical compound CN1CC(C(N)=N)C(=O)NC1=O IXPNQXFRVYWDDI-UHFFFAOYSA-N 0.000 description 1
- IBSREHMXUMOFBB-JFUDTMANSA-N 5u8924t11h Chemical compound O1[C@@H](C)[C@H](O)[C@@H](OC)C[C@@H]1O[C@@H]1[C@@H](OC)C[C@H](O[C@@H]2C(=C/C[C@@H]3C[C@@H](C[C@@]4(O3)C=C[C@H](C)[C@@H](C(C)C)O4)OC(=O)[C@@H]3C=C(C)[C@@H](O)[C@H]4OC\C([C@@]34O)=C/C=C/[C@@H]2C)/C)O[C@H]1C.C1=C[C@H](C)[C@@H]([C@@H](C)CC)O[C@]11O[C@H](C\C=C(C)\[C@@H](O[C@@H]2O[C@@H](C)[C@H](O[C@@H]3O[C@@H](C)[C@H](O)[C@@H](OC)C3)[C@@H](OC)C2)[C@@H](C)\C=C\C=C/2[C@]3([C@H](C(=O)O4)C=C(C)[C@@H](O)[C@H]3OC\2)O)C[C@H]4C1 IBSREHMXUMOFBB-JFUDTMANSA-N 0.000 description 1
- 239000005660 Abamectin Substances 0.000 description 1
- 241000239223 Arachnida Species 0.000 description 1
- 241000239290 Araneae Species 0.000 description 1
- 235000002566 Capsicum Nutrition 0.000 description 1
- 241000207199 Citrus Species 0.000 description 1
- 239000005654 Clofentezine Substances 0.000 description 1
- 229920000742 Cotton Polymers 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000238631 Hexapoda Species 0.000 description 1
- 239000005661 Hexythiazox Substances 0.000 description 1
- 241001091442 Hydrangeaceae Species 0.000 description 1
- 235000010643 Leucaena leucocephala Nutrition 0.000 description 1
- 240000007472 Leucaena leucocephala Species 0.000 description 1
- 229920001732 Lignosulfonate Polymers 0.000 description 1
- BACYUWVYYTXETD-UHFFFAOYSA-N N-Lauroylsarcosine Chemical compound CCCCCCCCCCCC(=O)N(C)CC(O)=O BACYUWVYYTXETD-UHFFFAOYSA-N 0.000 description 1
- IGFHQQFPSIBGKE-UHFFFAOYSA-N Nonylphenol Natural products CCCCCCCCCC1=CC=C(O)C=C1 IGFHQQFPSIBGKE-UHFFFAOYSA-N 0.000 description 1
- 229910019142 PO4 Inorganic materials 0.000 description 1
- 241000488581 Panonychus citri Species 0.000 description 1
- 206010034133 Pathogen resistance Diseases 0.000 description 1
- 239000006002 Pepper Substances 0.000 description 1
- 241000745988 Phyllostachys Species 0.000 description 1
- 235000016761 Piper aduncum Nutrition 0.000 description 1
- 235000017804 Piper guineense Nutrition 0.000 description 1
- 235000008184 Piper nigrum Nutrition 0.000 description 1
- 229920003171 Poly (ethylene oxide) Polymers 0.000 description 1
- 239000005663 Pyridaben Substances 0.000 description 1
- XUIMIQQOPSSXEZ-UHFFFAOYSA-N Silicon Chemical compound [Si] XUIMIQQOPSSXEZ-UHFFFAOYSA-N 0.000 description 1
- 241001454295 Tetranychidae Species 0.000 description 1
- 231100000605 Toxicity Class Toxicity 0.000 description 1
- HRKAMJBPFPHCSD-UHFFFAOYSA-N Tri-isobutylphosphate Chemical compound CC(C)COP(=O)(OCC(C)C)OCC(C)C HRKAMJBPFPHCSD-UHFFFAOYSA-N 0.000 description 1
- 229950008167 abamectin Drugs 0.000 description 1
- DPXJVFZANSGRMM-UHFFFAOYSA-N acetic acid;2,3,4,5,6-pentahydroxyhexanal;sodium Chemical compound [Na].CC(O)=O.OCC(O)C(O)C(O)C(O)C=O DPXJVFZANSGRMM-UHFFFAOYSA-N 0.000 description 1
- 239000000654 additive Substances 0.000 description 1
- 229910000147 aluminium phosphate Inorganic materials 0.000 description 1
- 230000003042 antagnostic effect Effects 0.000 description 1
- 230000002528 anti-freeze Effects 0.000 description 1
- 239000012752 auxiliary agent Substances 0.000 description 1
- 230000015572 biosynthetic process Effects 0.000 description 1
- OOCMUZJPDXYRFD-UHFFFAOYSA-L calcium;2-dodecylbenzenesulfonate Chemical compound [Ca+2].CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O.CCCCCCCCCCCCC1=CC=CC=C1S([O-])(=O)=O OOCMUZJPDXYRFD-UHFFFAOYSA-L 0.000 description 1
- 239000001768 carboxy methyl cellulose Substances 0.000 description 1
- 150000001732 carboxylic acid derivatives Chemical class 0.000 description 1
- 239000000969 carrier Substances 0.000 description 1
- 235000020971 citrus fruits Nutrition 0.000 description 1
- UXADOQPNKNTIHB-UHFFFAOYSA-N clofentezine Chemical compound ClC1=CC=CC=C1C1=NN=C(C=2C(=CC=CC=2)Cl)N=N1 UXADOQPNKNTIHB-UHFFFAOYSA-N 0.000 description 1
- 239000013530 defoamer Substances 0.000 description 1
- 238000011161 development Methods 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000007598 dipping method Methods 0.000 description 1
- 229960000878 docusate sodium Drugs 0.000 description 1
- YRIUSKIDOIARQF-UHFFFAOYSA-N dodecyl benzenesulfonate Chemical compound CCCCCCCCCCCCOS(=O)(=O)C1=CC=CC=C1 YRIUSKIDOIARQF-UHFFFAOYSA-N 0.000 description 1
- 229940071161 dodecylbenzenesulfonate Drugs 0.000 description 1
- 230000000857 drug effect Effects 0.000 description 1
- 235000013399 edible fruits Nutrition 0.000 description 1
- 239000003995 emulsifying agent Substances 0.000 description 1
- 230000037149 energy metabolism Effects 0.000 description 1
- 150000002148 esters Chemical class 0.000 description 1
- 150000002191 fatty alcohols Chemical class 0.000 description 1
- 230000035558 fertility Effects 0.000 description 1
- NVVZQXQBYZPMLJ-UHFFFAOYSA-N formaldehyde;naphthalene-1-sulfonic acid Chemical compound O=C.C1=CC=C2C(S(=O)(=O)O)=CC=CC2=C1 NVVZQXQBYZPMLJ-UHFFFAOYSA-N 0.000 description 1
- 238000007710 freezing Methods 0.000 description 1
- 230000002401 inhibitory effect Effects 0.000 description 1
- 238000011835 investigation Methods 0.000 description 1
- JEIPFZHSYJVQDO-UHFFFAOYSA-N iron(III) oxide Inorganic materials O=[Fe]O[Fe]=O JEIPFZHSYJVQDO-UHFFFAOYSA-N 0.000 description 1
- 239000007788 liquid Substances 0.000 description 1
- 230000005923 long-lasting effect Effects 0.000 description 1
- 238000005259 measurement Methods 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
- TVMXDCGIABBOFY-UHFFFAOYSA-N n-Octanol Natural products CCCCCCCC TVMXDCGIABBOFY-UHFFFAOYSA-N 0.000 description 1
- SNQQPOLDUKLAAF-UHFFFAOYSA-N nonylphenol Chemical compound CCCCCCCCCC1=CC=CC=C1O SNQQPOLDUKLAAF-UHFFFAOYSA-N 0.000 description 1
- 239000003921 oil Substances 0.000 description 1
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 description 1
- 239000003002 pH adjusting agent Substances 0.000 description 1
- 239000008177 pharmaceutical agent Substances 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K phosphate Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 229920000259 polyoxyethylene lauryl ether Polymers 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- ZYHMJXZULPZUED-UHFFFAOYSA-N propargite Chemical compound C1=CC(C(C)(C)C)=CC=C1OC1C(OS(=O)OCC#C)CCCC1 ZYHMJXZULPZUED-UHFFFAOYSA-N 0.000 description 1
- 229930195215 pungen Natural products 0.000 description 1
- DWFZBUWUXWZWKD-UHFFFAOYSA-N pyridaben Chemical compound C1=CC(C(C)(C)C)=CC=C1CSC1=C(Cl)C(=O)N(C(C)(C)C)N=C1 DWFZBUWUXWZWKD-UHFFFAOYSA-N 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 238000005070 sampling Methods 0.000 description 1
- 108700004121 sarkosyl Proteins 0.000 description 1
- 229910052710 silicon Inorganic materials 0.000 description 1
- 239000010703 silicon Substances 0.000 description 1
- 239000000661 sodium alginate Substances 0.000 description 1
- 235000010413 sodium alginate Nutrition 0.000 description 1
- 229940005550 sodium alginate Drugs 0.000 description 1
- 235000019812 sodium carboxymethyl cellulose Nutrition 0.000 description 1
- 229920001027 sodium carboxymethylcellulose Polymers 0.000 description 1
- APSBXTVYXVQYAB-UHFFFAOYSA-M sodium docusate Chemical compound [Na+].CCCCC(CC)COC(=O)CC(S([O-])(=O)=O)C(=O)OCC(CC)CCCC APSBXTVYXVQYAB-UHFFFAOYSA-M 0.000 description 1
- ZDQYSKICYIVCPN-UHFFFAOYSA-L sodium succinate (anhydrous) Chemical compound [Na+].[Na+].[O-]C(=O)CCC([O-])=O ZDQYSKICYIVCPN-UHFFFAOYSA-L 0.000 description 1
- HLPHHOLZSKWDAK-UHFFFAOYSA-M sodium;formaldehyde;naphthalene-1-sulfonate Chemical compound [Na+].O=C.C1=CC=C2C(S(=O)(=O)[O-])=CC=CC2=C1 HLPHHOLZSKWDAK-UHFFFAOYSA-M 0.000 description 1
- 239000002904 solvent Substances 0.000 description 1
- 238000005507 spraying Methods 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- BDHFUVZGWQCTTF-UHFFFAOYSA-M sulfonate Chemical compound [O-]S(=O)=O BDHFUVZGWQCTTF-UHFFFAOYSA-M 0.000 description 1
- 238000003786 synthesis reaction Methods 0.000 description 1
- 229940104261 taurate Drugs 0.000 description 1
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 description 1
- 235000013311 vegetables Nutrition 0.000 description 1
- 230000001018 virulence Effects 0.000 description 1
- 239000000080 wetting agent Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/90—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having two or more relevant hetero rings, condensed among themselves or with a common carbocyclic ring system
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01N—PRESERVATION OF BODIES OF HUMANS OR ANIMALS OR PLANTS OR PARTS THEREOF; BIOCIDES, e.g. AS DISINFECTANTS, AS PESTICIDES OR AS HERBICIDES; PEST REPELLANTS OR ATTRACTANTS; PLANT GROWTH REGULATORS
- A01N43/00—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds
- A01N43/02—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms
- A01N43/04—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom
- A01N43/06—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings
- A01N43/12—Biocides, pest repellants or attractants, or plant growth regulators containing heterocyclic compounds having rings with one or more oxygen or sulfur atoms as the only ring hetero atoms with one hetero atom five-membered rings condensed with a carbocyclic ring
Landscapes
- Life Sciences & Earth Sciences (AREA)
- Agronomy & Crop Science (AREA)
- Pest Control & Pesticides (AREA)
- Plant Pathology (AREA)
- Health & Medical Sciences (AREA)
- Engineering & Computer Science (AREA)
- Dentistry (AREA)
- General Health & Medical Sciences (AREA)
- Wood Science & Technology (AREA)
- Zoology (AREA)
- Environmental Sciences (AREA)
- Agricultural Chemicals And Associated Chemicals (AREA)
Abstract
The invention relates to an acaricidal composition containing Spidoxamat and spirodiclofen, wherein the effective active ingredients are Spidoxamat and spirodiclofen, and the weight ratio of Spidoxamat to spirodiclofen is 1: 10-10: 1. the composition can also be prepared into various dosage forms with other pesticide auxiliaries, and can generate a synergistic effect by adopting a certain mass proportion when in use, so that the use dosage of the composition can be reduced, and the generation of drug resistance of mites can be slowed down.
Description
Technical Field
The invention relates to a compound acaricide and application thereof, in particular to a composition containing Spidoxamt and spirodiclofen as main active ingredients, belonging to the technical field of pesticide compounding.
Technical Field
Mites belong to the class arachnida, and common harmful mites belong to the order true acarina and are one of important pests of crops and often damage various economic crops. The pest mites are one of pests which are difficult to control because of strong fecundity, serious generation overlapping, small bodies, concealed moving parts and fast resistance rising. At present, acaricides mostly aim at a certain period or a certain stage of acarids, such as hexythiazox, clofentezine and spirodiclofen, which mainly kill acarid eggs and are ineffective to adult acarids; propargite and abamectin are mainly used for killing nymphs and adult mites, and currently, medicaments which are effective in controlling harmful mites in the whole growth period in the market comprise pyridaben and spirodiclofen, so that the medicament compounding and the development of novel acaricides are concerned.
Spidoxamat is a spirocyclic tetronate acaricide. Their IUPAC names: 11- (4-chloro-2, 6-dimethylphenyl) -12-hydroxy-1, 4-dioxa-9-azadispiro [4.2.48.25] tetradec-11-en-10-one; CAS number 907187-07-9; the molecular formula is as follows: C19H22CINO 4. The structural formula is as follows:
the spirodiclofen has the action mechanism of inhibiting fat synthesis in pest mites, destroying the energy metabolism activity of the mites and finally killing the pest mites. The prevention and control characteristics are broad-spectrum acaricidal effect, killing of eggs and larvae, long lasting period, low toxicity, good safety, no cross resistance with other acaricides, and the defects of slow action speed and unsatisfactory acarid-forming effect. According to the national pesticide toxicity grading standard, the spirodiclofen belongs to a low-toxicity acaricidal agent. Is widely suitable for preventing and treating various mites, such as Tetranychidae apple, Panonychus citri of Citrus, Tetranychus gossypii, Tetranychus cinnabarinus, Tarsonchidae (Tarsonemus dorsalis), Hydrangeaceae (Nitrus pungens, grape rust), and Phyllostachys tenuis (short-whisker grape mite). However, the single preparation has the defects of easy generation of resistance and slow action speed in the use process.
At present, no relevant report of compounding Spidoxamat and spirodiclofen for preventing and controlling pest mites is found.
Disclosure of Invention
The invention uses Spidoxamat and spirodiclofen in a compounding way, and can be used for preventing and treating red spider mites, tetranychus urticae koch, tetranychus cinnabarinus and other agricultural pest mites of fruits, vegetables and crops.
The invention is realized by the following technical scheme.
The invention relates to an acaricidal composition, which comprises active ingredients of Spidoxamat and spirodiclofen in a weight ratio of 1: 10-10: 1, preferably 1:10-1:1, and more preferably 1: 5.
Further, the acaricidal composition also comprises auxiliary agents or fillers which are allowed to be used and accepted in pesticides.
Further, the acaricidal composition can be prepared into a pesticide formulation known in the art, and the specific pesticide formulation is one of conventional formulations such as a suspending agent, a water dispersible granule, missible oil and wettable powder. Optional adjuvants include, but are not limited to: solvents, emulsifiers, wetting and dispersing agents, thickeners, stabilizers, anti-freezing agents, pH regulators, carriers or fillers, and the like.
Further, the acaricidal composition is preferably prepared into a suspending agent, wherein the active ingredients Spidoxamat and spirodiclofen are used in an amount of 1-75%.
In the preparation of the above dosage forms, any of the usual types of adjuvants used in the processing of pesticide dosage forms may be selected, for example:
the wetting dispersant can be selected from: polyoxyethylene alkylphenol ether, dodecyl benzene sulfonate, lignosulfonate, naphthalene sulfonate formaldehyde condensate, sodium naphthalene sulfonate formaldehyde condensate, fatty alcohol polyoxyethylene ether phosphate, nonylphenol polyoxyethylene ether, sodium dodecyl sulfate, polyoxyethylene lauryl ether carboxylic acid sodium, calcium dodecyl benzene sulfonate, isooctyl ester succinate sodium sulfonate, oleoyl methyl taurate, lauroyl sarcosine sodium, dioctyl sulfosuccinate, polycarboxylate and the like.
The thickening agent can be selected from: xanthan gum, magnesium aluminum silicate, sodium alginate, sodium carboxymethylcellulose, and acacia.
The antifreeze can be selected from: one or more of glycerol, ethylene glycol and propylene glycol.
The defoaming agent can be one or more of organic silicon defoaming agent, isobutyl phosphate and n-octanol.
Optional pH adjusting agents may be selected from: one or more of citric acid and phosphoric acid.
The acaricidal composition of the invention is used for crops, fruits and vegetables to prevent and control acarid. The pest mites include Tetranychus urticae, Tetranychus cinnabarinus, etc.
Compared with the prior art, the invention has the following advantages:
the invention relates to a novel compound composition, which has obvious synergistic effect on tetranychus urticae koch when the mass ratio of Spidoxamat to spirodiclofen is 1:10-1: 1; can reduce the dosage of pesticide and delay the drug resistance. Therefore, the composition has wide application prospect in the field of acaricides.
Detailed Description
The following examples are given to aid the understanding of the invention, but do not limit the scope of the invention.
First, indoor acaricidal activity assay
1. Agent virulence assay
Testing insect sources: collecting Tetranychus urticae in the field, and feeding indoors;
test agents: spidoxamat technical, spirodiclofen technical;
the test method comprises the following steps: a leaf dipping method is adopted for reference (Li identification, indoor toxicity and field efficacy test of 9 acaricides on strawberry tetranychus urticae koch, northwest agricultural science), female adult mites with consistent physiological states are selected, the female adult mites are inoculated to strawberry leaves with good growth conditions, and after the tested mites are stable in activity, 40 adult mites on each leaf are cut off. According to the result of the preliminary test, 5 dilution concentrations and 1 blank control are respectively set for each medicament, the leaves are respectively immersed into the prepared medicaments, the medicaments are gently shaken and taken out after 10 seconds, redundant liquid medicine is sucked by filter paper and placed on a culture dish, in order to prevent the leaves from dehydrating and the tetranychus urticae from escaping, wet absorbent cotton is wrapped on the leaf edges, each treatment is repeated for 4 times, each treatment is placed in an artificial climate box, the survival condition of the tetranychus urticae is observed after 72 hours, the bodies of the tetranychus urticae are touched by a writing brush, the bodies of the tetranychus urticae are motionless, and the non-responders are marked as dead individuals. And counting the total mite number, death number and survival number of each treatment.
Mortality rate ═ (number of dead mites/number of mites tested) × 100%;
corrected mortality-control mortality)/(1-control mortality) x 100%
The obtained data is processed by DPS, and a toxicity regression equation and LC calculation are respectively established 50 Value and co-toxicity coefficient (CTC) of the compound.
Mix the mixtureEvaluation of the combination of agents by LC 50 Based on the combination, the combination effect type of the mixture is evaluated by calculating the co-toxicity coefficient of the mixture.
Wherein the co-toxicity coefficient standard is that CTC is more than or equal to 120 and is synergistic, CTC is more than or equal to 80 and is less than 120 and is additive, and CTC is less than 80 and is antagonistic.
2. Test results
The results of indoor toxicity measurement of Spidoxamat and spirodiclofen are shown in Table 1, and show that both the two agents have acaricidal effect, and LC of Spidoxamat 50 LC of spirodiclofen at 0.3943mg/L 50 It was 26.9157 mg/L. The two medicaments are compounded in a specific proportion to show a certain synergistic effect. When the mass ratio of Spidoxamat to spirodiclofen is 1:10-1:1, the composition has obvious synergistic effect on tetranychus urticae; when the mass ratio of Spidoxamat to spirodiclofen is 5:1-10:1, the composition has additive effect on Tetranychus urticae. When the composition has synergistic effect, the dosage of the medicament can be reduced, and the generation of drug resistance of the mites is slowed down.
TABLE 1 indoor toxicity determination of Spidoxamat and spirodiclofen at different ratios to Tetranychus urticae
Second, preparation examples
Example 1: 24% Spidoxamat spirodiclofen suspension
4 wt% of Spidoxamat, 20 wt% of spirodiclofen, D-4254 wt% of polycarboxylate, 4 wt% of calcium lignosulfonate, 0.2 wt% of xanthan gum, 0.1 wt% of magnesium aluminum silicate, 3 wt% of glycerol, 0.2 wt% of organosilicon antifoaming agent, 1 wt% of bentonite and deionized water for making up 100%.
Example 2: 10% Spidoxamat spirodiclofen suspension
Spidoxamat 5 wt%, spirodiclofen 5 wt%, polycarboxylate D-4253 wt%, calcium lignosulfonate 3 wt%, xanthan gum 0.3 wt%, magnesium aluminum silicate 0.1 wt%, glycerol 2 wt%, organosilicon defoamer 0.2 wt%, bentonite 1 wt%, and deionized water to make up 100%.
Example 3: 22% Spidoxamat spirodiclofen suspension
2 wt% of Spidoxamat, 20 wt% of spirodiclofen, 20 wt% of polycarboxylate D-4255 wt%, 2 wt% of calcium lignosulfonate, 0.4 wt% of xanthan gum, 0.2 wt% of magnesium aluminum silicate, 4 wt% of glycerol, 0.3 wt% of organosilicon antifoaming agent, 1 wt% of bentonite and deionized water for making up to 100%.
EXAMPLE 424% Spidoxam spirodiclofen wettable powder
4 wt% of Spidoxamat, 20 wt% of spirodiclofen, 8 wt% of sodium dodecyl sulfate, 4 wt% of calcium lignosulphonate, 5 wt% of white carbon black and the balance of kaolin to 100%.
Example 520% Spidoxam spirodiclofen wettable powder
10 wt% of Spidoxamat, 10 wt% of spirodiclofen, 6 wt% of sodium dodecyl sulfate, 8 wt% of calcium lignosulphonate, 3% of white carbon black and the balance of kaolin to 100%.
EXAMPLE 633% Spidoxamat spirodiclofen wettable powder
3 wt% of Spidoxamat, 30 wt% of spirodiclofen, 7 wt% of sodium dodecyl sulfate, 4 wt% of calcium lignosulphonate, 4 wt% of white carbon black and the balance of kaolin to 100%.
Third, field drug effect test
1. Test crops and pests: tetranychus capsici; the test period is the fruiting period of the pepper, and the growth vigor is good;
2. test agents: EXAMPLES 1 to 6 pharmaceutical agents
3. The test method comprises the following steps: the cells were set up as per the agent of table 2, 4 replicates per treatment, cell area 35m2, randomized block arrangement. Spraying the pesticide twice at intervals of 7 d; the population base number of the worms is investigated before the medicine, and the number of the surviving worms is investigated 7 days and 14 days after the second medicine. The investigation method comprises the following steps: sampling 5 points per cell, marking 25 pepper plants per cell with 5 pepper plants per point, fixing 5 leaves on the middle upper part of each pepper plant, and fixing the plants at fixed points to investigate the number of tetranychus urticae.
4. Test results
The results of field efficacy tests of Spidoxamat and spirodiclofen for controlling Tetranychus urticae are shown in Table 2, and it can be known from Table 2 that different examples have better control effects on Tetranychus urticae.
TABLE 2 results of the spider mite control test in different examples
All such substitutions and modifications will be apparent to those skilled in the art and are intended to be included within the scope of the present invention.
Claims (8)
1. The acaricidal composition is characterized in that the effective active ingredients are Spidoxamat and spirodiclofen, and the weight ratio of Spidoxamat to spirodiclofen is 1: 10-10: 1.
2. an acaricidal composition according to claim 1, characterized in that the weight ratio of Spidoxamat to spirodiclofen is preferably 1:10 to 1: 1.
3. a miticidal composition according to claim 2, characterized in that the weight ratio of Spidoxamat to spirodiclofen is further preferably 1: 5.
4. An acaricidal composition according to any one of claims 1 to 3, characterized in that it further comprises adjuvants or fillers permitted and accepted in pesticides.
5. A miticidal composition according to claim 4, in the form of suspension, water dispersible granules, emulsifiable concentrate or wettable powder.
6. An acaricidal composition according to claim 5, characterized in that the formulation of the acaricidal composition is preferably a suspension concentrate.
7. Use of the acaricidal composition according to any one of claims 1 to 6 for crops, fruits and vegetables for the control of acarids.
8. The use of claim 7, wherein the pest mites comprise tetranychus cinnabarinus or tetranychus urticae.
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