CN114786773B - 苯并硫杂氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 - Google Patents

苯并硫杂氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 Download PDF

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Publication number
CN114786773B
CN114786773B CN202080083824.3A CN202080083824A CN114786773B CN 114786773 B CN114786773 B CN 114786773B CN 202080083824 A CN202080083824 A CN 202080083824A CN 114786773 B CN114786773 B CN 114786773B
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China
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tetrahydro
dioxido
oxy
benzothiazepine
acetic acid
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CN202080083824.3A
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English (en)
Chinese (zh)
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CN114786773A (zh
Inventor
P-G.吉尔伯格
I.斯塔克
S.S.库尔卡尼
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Albireo AB
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Albireo AB
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Priority claimed from PCT/EP2020/084571 external-priority patent/WO2021110887A1/en
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

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  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CN202080083824.3A 2019-12-04 2020-12-04 苯并硫杂氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途 Active CN114786773B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201911049985 2019-12-04
IN201911049985 2019-12-04
PCT/EP2020/084571 WO2021110887A1 (en) 2019-12-04 2020-12-04 Benzothiazepine compounds and their use as bile acid modulators

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Publication Number Publication Date
CN114786773A CN114786773A (zh) 2022-07-22
CN114786773B true CN114786773B (zh) 2024-10-18

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ID=82196618

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CN202080083824.3A Active CN114786773B (zh) 2019-12-04 2020-12-04 苯并硫杂氮杂环庚三烯化合物及其作为胆汁酸调节剂的用途

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EP (1) EP4069362A1 (https=)
JP (1) JP7665621B2 (https=)
CN (1) CN114786773B (https=)
CA (1) CA3158175A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4188541B1 (en) * 2020-08-03 2024-12-25 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1292785A (zh) * 1998-01-10 2001-04-25 葛兰素集团有限公司 降低血脂的苯并硫氮䓬化合物
CN1481373A (zh) * 2000-12-21 2004-03-10 1,5-苯并硫氮杂�化合物及其作为降血脂药的应用
CN103228270A (zh) * 2010-11-08 2013-07-31 阿尔比里奥公司 含ibat抑制剂和胆汁酸结合剂的药物组合

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0121337D0 (en) * 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1292785A (zh) * 1998-01-10 2001-04-25 葛兰素集团有限公司 降低血脂的苯并硫氮䓬化合物
CN1481373A (zh) * 2000-12-21 2004-03-10 1,5-苯并硫氮杂�化合物及其作为降血脂药的应用
CN103228270A (zh) * 2010-11-08 2013-07-31 阿尔比里奥公司 含ibat抑制剂和胆汁酸结合剂的药物组合

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EP4069362A1 (en) 2022-10-12
JP2023504646A (ja) 2023-02-06
CA3158175A1 (en) 2021-06-10
CN114786773A (zh) 2022-07-22
JP7665621B2 (ja) 2025-04-21

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