CA3158175A1 - Benzothiazepine compounds and their use as bile acid modulators - Google Patents

Benzothiazepine compounds and their use as bile acid modulators Download PDF

Info

Publication number
CA3158175A1
CA3158175A1 CA3158175A CA3158175A CA3158175A1 CA 3158175 A1 CA3158175 A1 CA 3158175A1 CA 3158175 A CA3158175 A CA 3158175A CA 3158175 A CA3158175 A CA 3158175A CA 3158175 A1 CA3158175 A1 CA 3158175A1
Authority
CA
Canada
Prior art keywords
amino acid
acid position
tetrahydro
benzothiazepin
dioxido
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
CA3158175A
Other languages
English (en)
French (fr)
Inventor
Per-Goran Gillberg
Ingemar Starke
Santosh S. Kulkarni
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Albireo AB
Original Assignee
Albireo AB
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Albireo AB filed Critical Albireo AB
Priority claimed from PCT/EP2020/084571 external-priority patent/WO2021110887A1/en
Publication of CA3158175A1 publication Critical patent/CA3158175A1/en
Pending legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D281/00—Heterocyclic compounds containing rings of more than six members having one nitrogen atom and one sulfur atom as the only ring hetero atoms
    • C07D281/02—Seven-membered rings
    • C07D281/04—Seven-membered rings having the hetero atoms in positions 1 and 4
    • C07D281/08—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems
    • C07D281/10—Seven-membered rings having the hetero atoms in positions 1 and 4 condensed with carbocyclic rings or ring systems condensed with one six-membered ring
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P5/00—Drugs for disorders of the endocrine system

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Engineering & Computer Science (AREA)
  • Diabetes (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Endocrinology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
CA3158175A 2019-12-04 2020-12-04 Benzothiazepine compounds and their use as bile acid modulators Pending CA3158175A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
IN201911049985 2019-12-04
IN201911049985 2019-12-04
PCT/EP2020/084571 WO2021110887A1 (en) 2019-12-04 2020-12-04 Benzothiazepine compounds and their use as bile acid modulators

Publications (1)

Publication Number Publication Date
CA3158175A1 true CA3158175A1 (en) 2021-06-10

Family

ID=82196618

Family Applications (1)

Application Number Title Priority Date Filing Date
CA3158175A Pending CA3158175A1 (en) 2019-12-04 2020-12-04 Benzothiazepine compounds and their use as bile acid modulators

Country Status (4)

Country Link
EP (1) EP4069362A1 (https=)
JP (1) JP7665621B2 (https=)
CN (1) CN114786773B (https=)
CA (1) CA3158175A1 (https=)

Families Citing this family (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP4188541B1 (en) * 2020-08-03 2024-12-25 Albireo AB Benzothia(di)azepine compounds and their use as bile acid modulators

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB9800428D0 (en) * 1998-01-10 1998-03-04 Glaxo Group Ltd Chemical compounds
EG26979A (en) * 2000-12-21 2015-03-01 Astrazeneca Ab Chemical compounds
GB0121337D0 (en) * 2001-09-04 2001-10-24 Astrazeneca Ab Chemical compounds
JP6097695B2 (ja) * 2010-11-08 2017-03-15 アルビレオ アクチエボラグ Ｉｂａｔ阻害剤および胆汁酸結合剤を含む薬学的組み合わせ

Also Published As

Publication number Publication date
EP4069362A1 (en) 2022-10-12
CN114786773B (zh) 2024-10-18
JP2023504646A (ja) 2023-02-06
CN114786773A (zh) 2022-07-22
JP7665621B2 (ja) 2025-04-21

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