CN114786697A - 作用于蛋白激酶c(pkc)的二萜类化合物 - Google Patents
作用于蛋白激酶c(pkc)的二萜类化合物 Download PDFInfo
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- C07C2603/04—Ortho- or ortho- and peri-condensed systems containing three rings
- C07C2603/06—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members
- C07C2603/08—Ortho- or ortho- and peri-condensed systems containing three rings containing at least one ring with less than six ring members containing three- or four-membered rings
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- C07C2603/58—Ring systems containing bridged rings containing three rings
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- C07C2603/74—Adamantanes
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06026—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 0 or 1 carbon atom, i.e. Gly or Ala
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06043—Leu-amino acid
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- C07K5/06—Dipeptides
- C07K5/06008—Dipeptides with the first amino acid being neutral
- C07K5/06017—Dipeptides with the first amino acid being neutral and aliphatic
- C07K5/06034—Dipeptides with the first amino acid being neutral and aliphatic the side chain containing 2 to 4 carbon atoms
- C07K5/06052—Val-amino acid
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- C07K5/04—Peptides containing up to four amino acids in a fully defined sequence; Derivatives thereof containing only normal peptide links
- C07K5/08—Tripeptides
- C07K5/0802—Tripeptides with the first amino acid being neutral
- C07K5/0804—Tripeptides with the first amino acid being neutral and aliphatic
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| US201962905253P | 2019-09-24 | 2019-09-24 | |
| US62/905,253 | 2019-09-24 | ||
| PCT/US2020/052545 WO2021062030A1 (en) | 2019-09-24 | 2020-09-24 | Diterpenoid compounds that act on protein kinase c (pkc) |
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| CN114786697A true CN114786697A (zh) | 2022-07-22 |
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| WO2023033128A1 (ja) * | 2021-09-03 | 2023-03-09 | 国立大学法人京都大学 | タンパク質の製造方法 |
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| US20240197666A1 (en) * | 2021-03-23 | 2024-06-20 | K-Gen Therapeutics, Inc. | Diterpenoid compounds that act on protein kinase c (pkc) |
| CN118973565A (zh) * | 2022-02-17 | 2024-11-15 | Q生物股份有限公司 | 组合疗法 |
| WO2025226622A1 (en) * | 2024-04-22 | 2025-10-30 | The Board Of Trustees Of The Leland Stanford Junior University | Tigilanol tiglate analogs, phorbol analogs, prodrugs, synthetic methods, and methods of use |
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| US20110014699A1 (en) * | 2009-07-20 | 2011-01-20 | Wender Paul A | Prostratin analogs, bryostatin analogs, prodrugs, synthetic methods, and methods of use |
| CN106659705A (zh) * | 2014-09-10 | 2017-05-10 | 加利福尼亚大学董事会 | 通过prostratin靶向k‑ras介导的信号转导通路和恶性肿瘤 |
| WO2017156350A1 (en) * | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
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| US6063814A (en) * | 1997-04-14 | 2000-05-16 | Chang; Richard L. | Phorbol esters as anti-neoplastic and white blood cell elevating agents |
| CA2855932A1 (en) * | 2011-11-13 | 2013-05-16 | Blanchette Rockefeller Neurosciences Institute | Pkc activators and combinations thereof |
| NZ727304A (en) * | 2012-01-18 | 2018-08-31 | Biosuccess Biotech Co Ltd | Compositions and methods of use of phorbol esters for the treatment of stroke |
| MA40904A (fr) * | 2014-11-03 | 2017-09-12 | Hygeia Tech Inc | Compositions d'ester de phorbol et procédés pour traiter ou réduire la durée d'une cytopénie |
| US20180311209A1 (en) * | 2015-10-08 | 2018-11-01 | Cognitive Research Enterprises, Inc. | Dosing regimens of pkc activators |
| US20240197666A1 (en) * | 2021-03-23 | 2024-06-20 | K-Gen Therapeutics, Inc. | Diterpenoid compounds that act on protein kinase c (pkc) |
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Patent Citations (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20110014699A1 (en) * | 2009-07-20 | 2011-01-20 | Wender Paul A | Prostratin analogs, bryostatin analogs, prodrugs, synthetic methods, and methods of use |
| CN106659705A (zh) * | 2014-09-10 | 2017-05-10 | 加利福尼亚大学董事会 | 通过prostratin靶向k‑ras介导的信号转导通路和恶性肿瘤 |
| WO2017156350A1 (en) * | 2016-03-09 | 2017-09-14 | K-Gen, Inc. | Methods of cancer treatment |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2023033128A1 (ja) * | 2021-09-03 | 2023-03-09 | 国立大学法人京都大学 | タンパク質の製造方法 |
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| IL291697B1 (en) | 2025-03-01 |
| KR20220116143A (ko) | 2022-08-22 |
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