CN114773158A - Extraction process and production method of effective components of fresh pseudo-ginseng flower - Google Patents
Extraction process and production method of effective components of fresh pseudo-ginseng flower Download PDFInfo
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- CN114773158A CN114773158A CN202210447019.5A CN202210447019A CN114773158A CN 114773158 A CN114773158 A CN 114773158A CN 202210447019 A CN202210447019 A CN 202210447019A CN 114773158 A CN114773158 A CN 114773158A
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- 238000000605 extraction Methods 0.000 title claims abstract description 25
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- 241000180649 Panax notoginseng Species 0.000 claims abstract description 55
- 235000003143 Panax notoginseng Nutrition 0.000 claims abstract description 55
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- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 claims abstract description 11
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- 238000000034 method Methods 0.000 claims description 15
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- UGJAEDFOKNAMQD-MQNTZWLQSA-N (3S,9Z)-1,9-Heptadecadiene-4,6-diyn-3-ol Chemical compound CCCCCCC\C=C/CC#CC#C[C@@H](O)C=C UGJAEDFOKNAMQD-MQNTZWLQSA-N 0.000 claims description 9
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- KKAHGGJBKUXDNQ-KRWDZBQOSA-N panaxynol Natural products CCCCCCCC=CC=CCC#C[C@@H](O)C=C KKAHGGJBKUXDNQ-KRWDZBQOSA-N 0.000 claims description 8
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- JRLHSTVTOOELAF-KRWDZBQOSA-N dehydrofalcarinol Natural products O[C@@H](C=C)C#CC#CCC=CCCCCCC=C JRLHSTVTOOELAF-KRWDZBQOSA-N 0.000 description 1
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07C—ACYCLIC OR CARBOCYCLIC COMPOUNDS
- C07C29/00—Preparation of compounds having hydroxy or O-metal groups bound to a carbon atom not belonging to a six-membered aromatic ring
- C07C29/74—Separation; Purification; Use of additives, e.g. for stabilisation
- C07C29/76—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment
- C07C29/86—Separation; Purification; Use of additives, e.g. for stabilisation by physical treatment by liquid-liquid treatment
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- Organic Chemistry (AREA)
- Medicines Containing Plant Substances (AREA)
Abstract
The invention relates to the technical field of medicine extraction, and discloses an extraction process and a production method of active ingredients of fresh pseudo-ginseng flower, wherein the active ingredients of the fresh pseudo-ginseng flower comprise the following materials: pseudo-ginseng flower extract, honeysuckle flower extract, stem leaf extract, menthol, erythritol, essence, trehalose, glycerol and purified water. The invention extracts ginseng alkynol in the fresh notoginseng flower by a unique extraction process and adds the ginseng alkynol into a product, thereby effectively having stronger bacteriostatic action on gram-positive staphylococcus aureus, bacillus subtilis, candida, type II hemolytic streptococcus, pneumococcus, xanthomonas campestris, aspergillus versicolor and the like and killing mycobacterium tuberculosis and mycobacterium avium resisting isoniazid.
Description
Technical Field
The invention relates to the technical field of medicine extraction, in particular to an extraction process of effective components of fresh pseudo-ginseng flowers and a production method thereof.
Background
The panaxynol, also called falcarinol, is one of polyacetylene alcohol compounds with main carbon chain of C, and has the structure of 3(R) -heptadeca-1, 9(Z) -diene-4, 6-diyne-3 alcohol [2 ]. It is evolved from oleic acid in vivo, and is mainly distributed in high-grade plants of Araliaceae, Umbelliferae, etc., such as medicinal plants including Ginseng radix, Notoginseng radix and radix Saposhnikoviae, and edible plants including radix Dauci Sativae, herba Apii Graveolentis, and radix Raphani Save. Panaxynol was first discovered in carrots and scientists believe it has some anti-insect and anti-fungal activity. Domestic and foreign research also shows that panaxynol also has different pharmacological actions.
In the prior art, dry pseudo-ginseng flowers are mainly used, and a CO2 supercritical extraction technology is used for extraction, and the method mainly focuses on the technical research field. The highest content of the panaxydol in the pseudo-ginseng reported in the literature is 0.079%, the content of the panaxydol is low, and the actual application and production have no much research value, so the invention provides the process for extracting the effective components of the fresh pseudo-ginseng flowers and the production method thereof.
Disclosure of Invention
Technical problem to be solved
Aiming at the defects of the prior art, the invention provides an extraction process of active ingredients of fresh pseudo-ginseng flower and a production method thereof, and solves the problems in the background technology.
(II) technical scheme
In order to achieve the above purpose, the invention provides the following technical scheme: an extraction process of effective components of fresh notoginseng flower and a production method thereof, wherein the effective components of the fresh notoginseng flower are extracted from the following materials: pseudo-ginseng flower extract, honeysuckle flower extract, stem leaf extract, menthol, erythritol, essence, trehalose, glycerol and purified water.
Preferably, the effective components of the fresh pseudo-ginseng flower have the following specific gravity: 0.02-2.3% of pseudo-ginseng flower extract, 0.02-2.1% of honeysuckle extract, 0.02-1.5% of pseudo-ginseng stem and leaf extract, 0.1-0.9% of menthol, 0.2-3.5% of erythritol, 0.3-0.6% of essence, 0.25-3.6% of trehalose, 10.36-17.61% of glycerol and 70-90% of purified water.
Preferably, the extraction process comprises the following extraction steps:
s1, crushing fresh pseudo-ginseng to 800 meshes at a low temperature below 20 ℃ by a crusher, and then drying by the existing circulating fluidized bed technology;
s2, collecting fat-soluble components volatilized in the drying process by using a volatile oil collector;
s3, extracting and separating the fat-soluble components by using petroleum ether to obtain the fat-soluble components of the fresh notoginseng flowers, comparing, and refining the ginseng alkynol in the fresh notoginseng flowers, wherein the total amount of the fat-soluble components prepared by using the fresh notoginseng flowers is 3 times of that of the dried notoginseng flowers.
Preferably, the production method of the fresh pseudo-ginseng flower related product is as follows:
SS1, refining the honeysuckle and the stem and leaf of the pseudo-ginseng by the steps of claim 3 to obtain honeysuckle extract and pseudo-ginseng stem and leaf extract;
SS2, adding Notoginseng flower extract, flos Lonicerae extract and Notoginseng stem and leaf extract into sterilized container;
SS3, adding purified water into a container, mixing with Notoginseng flower extract, flos Lonicerae extract and Notoginseng stem and leaf extract, and removing impurities to obtain medicinal liquid 1;
SS4, adding menthol, erythritol, essence, trehalose and glycerol into the liquid medicine 1, stirring and mixing to obtain the product liquid medicine;
SS5, placing the product liquid medicine in a constant temperature and humidity box with the temperature of 54 ℃ and the relative humidity of 85% for 14 days, taking out the product liquid medicine, and checking the bacteriostasis rate of the product liquid medicine.
Preferably, the pseudo-ginseng flower, the honeysuckle and the pseudo-ginseng stem leaf are all fresh raw materials picked within eight hours.
Preferably, the panaxynol extracted from the notoginseng flowers has strong bacteriostatic action □ on gram-positive staphylococcus aureus, bacillus subtilis, candida, type II hemolytic streptococcus, pneumococcus, xanthomonas campestris, aspergillus versicolor and the like, and can kill mycobacterium tuberculosis and mycobacterium avium with resistance to isoniazid.
Preferably, the honeysuckle is sweet and cold in nature, has the functions of clearing away heat and toxic materials, diminishing inflammation and relieving swelling, and is effective on bacillary dysentery and various pyogenic diseases.
(III) advantageous effects
Compared with the prior art, the invention provides an extraction process of effective components of fresh notoginseng flower and a production method thereof, and the extraction process has the following beneficial effects:
the invention extracts ginseng alkynol in the fresh notoginseng flower by a unique extraction process and adds the ginseng alkynol into a product, thereby effectively having stronger bacteriostatic action on gram-positive staphylococcus aureus, bacillus subtilis, candida, type II hemolytic streptococcus, pneumococcus, xanthomonas campestris, aspergillus versicolor and the like and killing mycobacterium tuberculosis and mycobacterium avium resisting isoniazid.
Drawings
FIG. 1 is a schematic diagram of the stability experiment of the process for extracting the effective components of fresh notoginseng flower and the production method thereof;
fig. 2 is an experimental schematic diagram of effective component extraction process of fresh notoginseng flower and its production method for bacteriostasis effect.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to the drawings in the embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments. All other embodiments, which can be obtained by a person skilled in the art without making any creative effort based on the embodiments in the present invention, belong to the protection scope of the present invention.
Referring to fig. 1-2, the present invention provides a technical solution: the effective components of the fresh pseudo-ginseng flower are extracted from the following materials: the fresh pseudo-ginseng flower tea comprises a pseudo-ginseng flower extract, a honeysuckle flower extract, a stem leaf extract, menthol, erythritol, essence, trehalose, glycerol and purified water, wherein the proportion of materials required by extracting active ingredients of the fresh pseudo-ginseng flower is as follows: 0.02-2.3% of pseudo-ginseng flower extract, 0.02-2.1% of honeysuckle extract, 0.02-1.5% of pseudo-ginseng stem and leaf extract, 0.1-0.9% of menthol, 0.2-3.5% of erythritol, 0.3-0.6% of essence, 0.25-3.6% of trehalose, 10.36-17.61% of glycerol and 70-90% of purified water, wherein the extraction process comprises the following extraction steps: s1, crushing fresh pseudo-ginseng to 800 meshes at a low temperature below 20 ℃ by a crusher, and then drying by the existing circulating fluidized bed technology; s2, collecting fat-soluble components volatilized in the drying process by using a volatile oil collector; s3, extracting and separating the fat-soluble components by using petroleum ether to obtain the fat-soluble components of the fresh notoginseng flowers, comparing, and refining ginseng alkynol in the fresh notoginseng flowers by using the fresh notoginseng flowers to obtain the fat-soluble components with the total amount being 3 times of that of the dried notoginseng flowers, wherein the production method of the related products of the fresh notoginseng flowers comprises the following steps: SS1, refining the honeysuckle and the stem and leaf of the pseudo-ginseng by the steps of claim 3 to obtain honeysuckle extract and pseudo-ginseng stem and leaf extract; SS2, adding Notoginseng flower extract, flos Lonicerae extract and Notoginseng stem and leaf extract into sterilized container; SS3, adding purified water into a container, mixing with Notoginseng flower extract, flos Lonicerae extract and Notoginseng stem and leaf extract, and removing impurities to obtain medicinal liquid 1; SS4, adding menthol, erythritol, essence, trehalose and glycerol into the liquid medicine 1, stirring and mixing to obtain the product liquid medicine; SS5, placing the product liquid medicine in a constant temperature and humidity box with the temperature of 54 ℃ and the relative humidity of 85% for 14 days, taking out the product liquid medicine, and checking the bacteriostasis rate of the product liquid medicine, wherein the notoginseng flowers, the honeysuckle and the notoginseng stems and leaves all adopt fresh raw materials picked within eight hours, the panaxynol extracted from the notoginseng flowers has stronger bacteriostasis □ on gram-positive staphylococcus aureus, bacillus subtilis, candida, type II hemolytic streptococcus, pneumococcus, xanthomonas campestris, aspergillus versicolor and the like, and can kill mycobacterium tuberculosis and mycobacterium avium resisting isoniazid, the honeysuckle is sweet and cold in nature, has the functions of clearing heat and detoxicating, diminishing inflammation and detumescence, and is effective on bacterial dysentery and various pyogenic diseases.
The extraction process comprises the following extraction steps:
s1, crushing fresh pseudo-ginseng to 800 meshes at a low temperature below 20 ℃ by a crusher, and then drying by the existing circulating fluidized bed technology;
s2, collecting fat-soluble components volatilized in the drying process by using a volatile oil collector;
s3, extracting and separating the fat-soluble components by using petroleum ether to obtain the fat-soluble components of the fresh notoginseng flower, comparing, and refining the ginseng alkynol in the fresh notoginseng flower, wherein the total amount of the fat-soluble components prepared by using the fresh notoginseng flower is 3 times of that of the dried notoginseng flower.
The production method of the fresh pseudo-ginseng flower related product comprises the following steps:
SS1, refining the honeysuckle and the stem and leaf of the pseudo-ginseng by the steps of claim 3 to obtain honeysuckle extract and pseudo-ginseng stem and leaf extract;
SS2, adding Notoginseng flower extract, flos Lonicerae extract and Notoginseng stem and leaf extract into sterilized container;
SS3, adding purified water into a container, mixing with Notoginseng flower extract, flos Lonicerae extract and Notoginseng stem and leaf extract, and removing impurities to obtain medicinal liquid 1;
SS4, adding menthol, erythritol, essence, trehalose and glycerol into the liquid medicine 1, stirring and mixing to obtain the product liquid medicine;
SS5, placing the product liquid medicine in a constant temperature and humidity box with the temperature of 54 ℃ and the relative humidity of 85% for 14 days, taking out the product liquid medicine, and checking the bacteriostasis rate of the product liquid medicine.
In conclusion, the extraction process and the production method of the active ingredients of the fresh pseudo-ginseng flowers extract the panaxynol in the fresh pseudo-ginseng flowers through the unique extraction process and add the panaxynol into the product, thereby effectively having stronger bacteriostatic action on gram-positive staphylococcus aureus, bacillus subtilis, candida, type II hemolytic streptococcus, pneumococcus and xanthomonas campestris, aspergillus versicolor and the like, and being capable of killing mycobacterium tuberculosis and mycobacterium avium for resisting isoniazid.
It should be noted that, in this document, relational terms such as first and second, and the like are used solely to distinguish one entity or action from another entity or action without necessarily requiring or implying any actual such relationship or order between such entities or actions. Also, the terms "comprises," "comprising," or any other variation thereof, are intended to cover a non-exclusive inclusion, such that a process, method, article, or apparatus that comprises a list of elements does not include only those elements but may include other elements not expressly listed or inherent to such process, method, article, or apparatus. Without further limitation, an element defined by the phrase "comprising an … …" does not exclude the presence of other identical elements in the process, method, article, or apparatus that comprises the element.
Although embodiments of the present invention have been shown and described, it will be appreciated by those skilled in the art that various changes, modifications, substitutions and alterations can be made in these embodiments without departing from the principles and spirit of the invention, the scope of which is defined in the appended claims and their equivalents.
Claims (7)
1. An extraction process of effective components of fresh notoginseng flower and a production method thereof are characterized in that: the effective components of the fresh pseudo-ginseng flower are extracted from the following materials: pseudo-ginseng flower extract, honeysuckle flower extract, stem leaf extract, menthol, erythritol, essence, trehalose, glycerol and purified water.
2. The process for extracting effective components of fresh notoginseng flower and the production method thereof according to claim 1, characterized in that: the effective components of the fresh pseudo-ginseng flower are extracted by the following materials in percentage by weight: 0.02-2.3% of pseudo-ginseng flower extract, 0.02-2.1% of honeysuckle extract, 0.02-1.5% of pseudo-ginseng stem and leaf extract, 0.1-0.9% of menthol, 0.2-3.5% of erythritol, 0.3-0.6% of essence, 0.25-3.6% of trehalose, 10.36-17.61% of glycerol and 70-90% of purified water.
3. The process for extracting effective components of fresh notoginseng flower and the production method thereof according to claim 1, characterized in that: the extraction process comprises the following extraction steps:
s1, crushing fresh pseudo-ginseng to 800 meshes at a low temperature below 20 ℃ by a crusher, and then drying by utilizing the existing circulating fluidized bed technology;
s2, collecting fat-soluble components volatilized in the drying process by using a volatile oil collector;
s3, extracting and separating the fat-soluble components by using petroleum ether to obtain the fat-soluble components of the fresh notoginseng flowers, comparing, and refining the ginseng alkynol in the fresh notoginseng flowers, wherein the total amount of the fat-soluble components prepared by using the fresh notoginseng flowers is 3 times of that of the dried notoginseng flowers.
4. The process for extracting effective components of fresh notoginseng flower and the production method thereof according to claim 3, characterized in that: the production method of the fresh pseudo-ginseng flower related product comprises the following steps:
SS1, extracting flos Lonicerae and Notoginseng radix stem and leaf by the steps of claim 3 to obtain flos Lonicerae extract and Notoginseng radix stem and leaf extract;
SS2, adding Notoginseng flower extract, flos Lonicerae extract and Notoginseng stem and leaf extract into sterilized container;
SS3, adding purified water into a container, mixing with Notoginseng flower extract, flos Lonicerae extract and Notoginseng stem and leaf extract, and removing impurities to obtain medicinal liquid 1;
SS4, adding menthol, erythritol, essence, trehalose and glycerol into the liquid medicine 1, stirring and mixing to obtain the product liquid medicine;
SS5, placing the product liquid medicine in a constant temperature and humidity box with the temperature of 54 ℃ and the relative humidity of 85% for 14 days, taking out the product liquid medicine, and checking the bacteriostasis rate of the product liquid medicine.
5. The process for extracting effective components of fresh notoginseng flower and the production method thereof according to claim 1, characterized in that: the pseudo-ginseng flower, the honeysuckle and the pseudo-ginseng stem leaf are all fresh raw materials picked within eight hours.
6. The process for extracting effective components of fresh notoginseng flowers and the production method thereof according to claim 1, characterized in that: the panaxynol extracted from Notoginseng radix has strong antibacterial effect □ on gram positive Staphylococcus aureus, Bacillus subtilis, Candida, type II hemolytic streptococcus, Diplococcus pneumoniae, Vanilla chrysogenum, Aspergillus versicolor, etc., and can kill Mycobacterium tuberculosis and Mycobacterium avium resisting isoniazid.
7. The process for extracting effective components of fresh notoginseng flower and the production method thereof according to claim 1, characterized in that: the honeysuckle flower is sweet and cold in nature, has the functions of clearing away heat and toxic materials, diminishing inflammation and relieving swelling, and is effective on bacillary dysentery and various pyogenic diseases.
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| Application Number | Priority Date | Filing Date | Title |
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| CN202210447019.5A CN114773158A (en) | 2022-04-26 | 2022-04-26 | Extraction process and production method of effective components of fresh pseudo-ginseng flower |
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| Publication number | Priority date | Publication date | Assignee | Title |
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| CN115868527A (en) * | 2022-12-29 | 2023-03-31 | 西南林业大学 | Novel plant preservative and preparation method and application thereof |
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| CN101460473A (en) * | 2006-04-03 | 2009-06-17 | 药物热化学品公司 | Thermal extraction method and product |
| CN108261434A (en) * | 2018-03-09 | 2018-07-10 | 云南金七制药有限公司 | Sanchi flower, stem-leaf extract, the instant tea containing sanchi flower, stem-leaf extract, and preparation method thereof |
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| CN101460473A (en) * | 2006-04-03 | 2009-06-17 | 药物热化学品公司 | Thermal extraction method and product |
| CN108261434A (en) * | 2018-03-09 | 2018-07-10 | 云南金七制药有限公司 | Sanchi flower, stem-leaf extract, the instant tea containing sanchi flower, stem-leaf extract, and preparation method thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115868527A (en) * | 2022-12-29 | 2023-03-31 | 西南林业大学 | Novel plant preservative and preparation method and application thereof |
| CN115868527B (en) * | 2022-12-29 | 2024-05-10 | 西南林业大学 | Plant preservative and preparation method and application thereof |
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