CN114767825B

CN114767825B - Traditional Chinese medicine shampoo for blackening hair and relieving itching

Info

Publication number: CN114767825B
Application number: CN202210486620.5A
Authority: CN
Inventors: 金丽华; 胡德新
Original assignee: Second Affiliated Hospital of ZCMU
Current assignee: Second Affiliated Hospital of ZCMU
Priority date: 2022-05-06
Filing date: 2022-05-06
Publication date: 2022-11-08
Anticipated expiration: 2042-05-06
Also published as: CN114767825A

Abstract

The invention relates to a traditional Chinese medicine shampoo for blackening hair and relieving itching, which is prepared by mixing a traditional Chinese medicine extracting solution and fermentation auxiliary materials, then fermenting, and then adding pharmaceutically acceptable auxiliary materials, wherein the traditional Chinese medicine extracting solution is prepared from cacumen biotae, radix polygoni multiflori preparata, ginger, glossy privet fruit, eclipta alba, garden balsam stem, cortex dictamni, fructus kochiae, radix stemonae preparata, rhizoma drynariae, parasitic loranthus, tribulus terrestris, radix sophorae flavescentis, radix sileris, white muscardine silkworm, periostracum cicadae, radix astragali, angelica sinensis, hairyvein agrimony, radix salviae miltiorrhizae and rhodiola rosea. The traditional Chinese medicine shampoo disclosed by the invention is reasonable in design and compatible with each other, has a good treatment effect on hair blacking and scalp itching, and is less in adverse reaction during medication.

Description

Traditional Chinese medicine shampoo capable of blackening hair and relieving itching

Technical Field

The invention relates to the field of traditional Chinese medicines, and particularly relates to a traditional Chinese medicine shampoo capable of blackening hair and relieving itching.

Background

The white hair is the phenomenon that the hair is completely whitened or partially whitened abnormally, and the white hair proportion of people in all ages such as middle-aged people, young people and teenagers is increased remarkably along with the increase of the burden of brain labor force of modern people, so that the serious trouble is brought to the life and work of people. According to statistics, the few-white-head patients in China account for about 20-30% of the adult population and are in a growing trend. Although the demand of people for hair blacking is greatly increased, western medicine hair blacking products on the market have limited using effect, the western medicine has large side effect, and the phenomenon of relapse after medicine withdrawal is common. Compared with the traditional Chinese medicine, the traditional Chinese medicine has the advantages of safety, small toxic and side effects, low cost and the like in the aspect of hair blacking.

The traditional Chinese medicine has a long history of being applied to white hair, and the traditional Chinese medicine considers that the premature whitening of the hair has three reasons: white hair caused by kidney yin deficiency, white hair caused by yin deficiency and blood heat, and white hair caused by liver depression and qi stagnation. Although there is no unified view and ramifications on white hair in TCM, it is mainly located in liver, kidney and spleen. Liver and kidney deficiency, deficiency of both qi and blood, ascending of blood heat and emotional depression may promote early graying of beard and hair. According to a large amount of records of ancient medicine and analysis of prescription, deficiency of liver and kidney is the main reason for white hair.

At present, there are three main methods for treating white hair in traditional Chinese medicine: (1) systematic syndrome differentiation treatment, namely oral decoction. Liver and kidney deficiency type is mainly based on the principle of nourishing liver and kidney, and the main drug of the medicine is Liuwei Dihuang pill and Erzhi pill. The qi and blood deficiency type is based on the principle of replenishing qi and enriching blood, and the herbs are mainly four-ingredient decoction and Shenyingyangzhen decoction. Blood-heat ascending type is based on the principle of clearing heat and cooling blood, and most herbs are Xijiao Dihuang Tang and Xun Xue Si Wu Tang. For stagnation of emotion and depression, qi stagnation and blood stasis are usually caused, so this type is mostly based on soothing liver and qi stagnation, activating blood and resolving stasis, and the formula is mostly based on chai Hu Shu san and Xiao Yao san. (2) Acupuncture therapy, combining syndrome differentiation and typing, selects points to treat, and can also directly tap and prick the skin at the pathological changes with plum-blossom needles. However, these methods only stay at the level of personal experience, lack sufficient data support of clinical research, and the exact therapeutic effect still needs to be further determined. (3) The external treatment method comprises directly applying the medicine on affected part to improve hair growth. The method avoids systemic metabolism of the medicine, and has direct action and convenient use.

Although the traditional Chinese herbal medicine compound for treating blacking hair and relieving itching in the existing literature has more reports, the effect is not obvious and the treatment period is long, so that most of white hair patients mainly dye hair at present, and the traditional Chinese medicine preparation with the obvious effects of blacking hair and relieving itching still has wide market prospect.

Disclosure of Invention

The invention aims to provide a traditional Chinese medicine shampoo capable of effectively blacking hair and relieving itching.

In order to achieve the purpose, the invention adopts the following technical scheme:

the invention provides a traditional Chinese medicine shampoo for blackening hair and relieving itching, which is prepared by mixing a traditional Chinese medicine extracting solution and fermentation auxiliary materials, then fermenting, and then adding pharmaceutically acceptable auxiliary materials, wherein the traditional Chinese medicine extracting solution is prepared from cacumen biotae, radix polygoni multiflori preparata, ginger, glossy privet fruit, eclipta alba, garden balsam stem, cortex dictamni, fructus kochiae, radix stemonae preparata, rhizoma drynariae, parasitic loranthus, tribulus terrestris, radix sophorae flavescentis, radix sileris, white muscardine silkworm, cicada slough, astragalus mongholicus, angelica sinensis, hairyvein agrimony, salvia miltiorrhiza and rhodiola rosea.

Preferably, the traditional Chinese medicine extracting solution is prepared from 10-50 parts by weight of cacumen biotae, 5-25 parts by weight of radix polygoni multiflori preparata, 1-20 parts by weight of ginger, 5-25 parts by weight of glossy privet fruit, 5-25 parts by weight of eclipta alba, 5-25 parts by weight of garden balsam stem, 5-25 parts by weight of cortex dictamni, 5-25 parts by weight of fructus kochiae, 5-25 parts by weight of radix stemonae preparata, 1-20 parts by weight of rhizoma drynariae, 10-50 parts by weight of parasitic loranthus, 5-25 parts by weight of tribulus terrestris, 5-25 parts by weight of radix sophorae flavescentis, 1-15 parts by weight of radix saposhnikoviae, 1-20 parts by weight of silkworm larva, 1-20 parts by weight of periostracum cicadae, 10-50 parts by weight of astragalus root, 5-35 parts by weight of angelica sinensis, 10-50 parts by weight of hairyvein agrimony, 5-25 parts by weight of salvia miltiorrhiza and 5-35 parts by weight of rhodiola rosea.

More preferably, the traditional Chinese medicine extracting solution is prepared from 20-40 parts by weight of cacumen biotae, 10-20 parts by weight of radix polygoni multiflori preparata, 5-15 parts by weight of ginger, 10-20 parts by weight of glossy privet fruit, 10-20 parts by weight of eclipta alba, 10-20 parts by weight of garden balsam stem, 10-20 parts by weight of cortex dictamni, 10-20 parts by weight of fructus kochiae, 10-20 parts by weight of radix stemonae preparata, 5-15 parts by weight of rhizoma drynariae, 20-40 parts by weight of parasitic loranthus, 10-20 parts by weight of tribulus terrestris, 10-20 parts by weight of radix sophorae flavescentis, 1-10 parts by weight of radix sileris, 5-15 parts by weight of white muscardine silkworm, 5-15 parts by weight of periostracum cicada, 20-40 parts by weight of radix astragali, 10-30 parts by weight of angelica sinensis, 20-40 parts by weight of hairyvein agrimony, 10-20 parts by weight of radix salviae and 10-30 parts by weight of rhodiola rosea.

Most preferably, the traditional Chinese medicine extracting solution is prepared from 30 parts by weight of cacumen biotae, 15 parts by weight of radix polygoni multiflori preparata, 10 parts by weight of ginger, 15 parts by weight of glossy privet fruit, 15 parts by weight of eclipta alba, 15 parts by weight of garden balsam stem, 15 parts by weight of cortex dictamni, 15 parts by weight of fructus kochiae, 15 parts by weight of radix stemonae preparata, 10 parts by weight of rhizoma drynariae, 30 parts by weight of parasitic loranthus, 15 parts by weight of fructus tribuli, 15 parts by weight of radix sophorae flavescentis, 6 parts by weight of radix sileris, 10 parts by weight of silkworm larva, 10 parts by weight of periostracum cicadae, 30 parts by weight of radix astragali, 20 parts by weight of angelica sinensis, 30 parts by weight of hairyvein agrimonia herb, 15 parts by weight of radix salviae and 20 parts by weight of rhodiola rosea.

Preferably, the fermentation auxiliary materials comprise 40-60 parts by weight of tea bran, 10-30 parts by weight of rice, 10-30 parts by weight of sticky rice, 20-40 parts by weight of red yeast rice and 40-60 parts by weight of masson pine needle.

More preferably, the fermentation auxiliary materials comprise 50 parts by weight of tea bran, 20 parts by weight of rice, 20 parts by weight of sticky rice, 30 parts by weight of red yeast rice and 50 parts by weight of masson pine needles.

Preferably, the pharmaceutically acceptable auxiliary materials comprise one or more of an amino acid foaming agent, a polyquaternium, an amino acid humectant, glycerol, a thickener and an antibacterial agent.

Preferably, the amino acid foaming agent is LS-30.

Preferably, the polyquaternium is polyquaternium-10.

Preferably, the amino acid humectant is NMF-50.

Preferably, the thickener is PEG6000.

Preferably, the antibacterial agent is phenoxyethanol.

Preferably, the pharmaceutically acceptable auxiliary materials comprise an amino acid foaming agent, a polyquaternium, an amino acid humectant, glycerol, a thickening agent and an antibacterial agent.

Preferably, the pharmaceutically acceptable auxiliary materials in the traditional Chinese medicine shampoo comprise the following components in percentage by weight: 30% of amino acid foaming agent, 0.5% of polyquaternium, 6% of amino acid humectant, 6% of glycerin, 3.5% of thickening agent and 0.5% of antibacterial agent.

More preferably, the pharmaceutically acceptable auxiliary materials in the traditional Chinese medicine shampoo comprise the following components in percentage by weight: 30% LS-30, 0.5% polyquaternium-10, 6% NMF-50, 6% glycerol, 3.5% PEG6000 and 0.5% phenoxyethanol.

The second aspect of the invention provides a preparation method of the traditional Chinese medicine shampoo, which comprises the following steps:

(1) Taking the prescription amount of cacumen biotae, radix polygoni multiflori preparata, ginger, glossy privet fruit, eclipta alba, garden balsam stem, cortex dictamni, fructus kochiae, radix stemonae preparata, rhizoma drynariae, parasitic loranthus, tribulus terrestris, radix sophorae flavescentis, radix saposhnikoviae, white muscardine silkworm, periostracum cicadae, astragalus mongholicus, angelica sinensis, hairyvein agrimony, the root of red-rooted salvia and rhodiola rosea, adding distilled water with the weight being 2-5 times of that of the traditional Chinese medicines into the raw materials, decocting the raw materials, filtering the decoction, concentrating the decoction until the volume of the distilled water is half of that of the traditional Chinese medicine is added into the raw materials, and preparing a traditional Chinese medicine extracting solution;

(2) And (2) respectively taking tea bran, rice, sticky rice, red yeast rice and masson pine needles according to the prescription amount, fully mixing the tea bran, the rice, the sticky rice, the red yeast rice and the masson pine needle with the traditional Chinese medicine extracting solution obtained in the step (1), fermenting at room temperature for 3 weeks, filtering, boiling for sterilization, and adding an amino acid foaming agent, a polyquaternary ammonium salt, an amino acid humectant, glycerol, a thickening agent and an antibacterial agent according to the prescription amount to obtain the traditional Chinese medicine composition.

Preferably, distilled water with the weight 3 times of that of the traditional Chinese medicinal materials is added in the step (1) for decoction.

The third aspect of the invention is to provide application of the traditional Chinese medicine shampoo in preparing medicines for treating white hair.

The fourth aspect of the invention is to provide application of the traditional Chinese medicine shampoo in preparing a medicine for treating scalp pruritus.

The common pharmacological effects of the traditional Chinese medicine raw materials selected by the invention in the field are as follows:

ce Bai Ye, cold in nature, bitter and astringent in flavor, enters lung meridian, liver meridian and spleen meridian. Folium Platycladi has effects in cooling blood, stopping bleeding, promoting hair growth, and blackening hair, and can be used for treating hematemesis, epistaxis, hemoptysis, hematochezia, metrorrhagia, metrostaxis, and alopecia due to blood heat.

He shou Wu is warm in nature, bitter, sweet and astringent in flavor, and enters liver meridian, kidney meridian and heart meridian. Polygoni Multiflori radix has effects of removing toxic substance, resolving carbuncle, loosening bowel, and relieving constipation, and can be used for treating scrofula, sore, carbuncle, rubella, pruritus, constipation due to intestinal dryness, and hyperlipidemia.

Ginger, rhizoma Zingiberis recens, pungent and slightly warm, enters lung, spleen and stomach meridians. Rhizoma Zingiberis recens has effects of relieving exterior syndrome, dispelling cold, warming middle energizer, relieving vomit, eliminating phlegm and relieving cough, and can be used for treating wind-cold type common cold, stomach cold type emesis, and cough due to cold phlegm.

Fructus Ligustri Lucidi, neutral in nature, sweet and bitter in flavor, enters liver and kidney meridians. Fructus Ligustri Lucidi has effects in nourishing yin, prolonging life, tonifying liver and kidney, clearing away heat, improving eyesight, blackening hair, and can be used for treating dizziness, tinnitus, dim eyesight, soreness of waist and knees, internal heat, and premature gray hair.

Eclipta alba is cold in nature, sweet and sour in flavor and enters kidney and liver meridians. Herba Ecliptae has effects in nourishing liver and kidney, cooling blood, and stopping bleeding, and can be used for treating deficiency of liver-yin and kidney-yin, odontoseisis, premature gray hair, giddiness tinnitus, soreness of waist and knees, yin deficiency, blood heat, hematemesis, epistaxis, hematuria, bloody flux, metrorrhagia, metrostaxis, and traumatic hemorrhage.

Tu Yao is warm in nature and pungent in flavor, and enters kidney and liver meridians. Herba Speranskiae Tuberculatae has effects of dispelling pathogenic wind and removing dampness, relieving rigidity of muscles and promoting blood circulation, removing blood stasis and detumescence, removing toxic substance and relieving pain, and can be used for treating rheumatalgia, tendons and bones contracture, cold dampness loempe, waist sprain, paralysis, amenorrhea, eczema of scrotum, sore furuncle, and pyogenic infections.

Dictamni Radicis, cold in nature, bitter in taste, enters spleen and stomach meridians. Cortex Dictamni Radicis has effects of clearing heat, eliminating dampness, dispelling pathogenic wind and removing toxic substance, and can be used for treating damp-heat sore, impetigo, eczema, rubella, scabies, sore scabies, rheumatic arthralgia, jaundice and dark urine.

Kochiae fructus, cold in nature, sweet and bitter in taste, enters kidney and bladder meridians. Kochiae fructus has effects of clearing away dampness and heat, and relieving itching, and can be used for treating skin pruritus, urticaria, eczema, and dysuresia.

Stemona root, radix Stemonae, sweet and bitter in flavor, slightly warm in nature, enters lung meridian. Radix Stemonae has effects of moistening lung, descending qi, relieving cough, and killing parasite, and can be used for treating cough due to old-term illness, tuberculosis, pertussis, head lice, body lice, enterobiasis, and pruritus vulvae.

Gu sui Bu is warm in nature and bitter in taste, entering liver and kidney meridians. Rhizoma Drynariae can relieve pain, tonify kidney and strengthen bone, and can be used for treating lumbago due to kidney deficiency, toothache, tinnitus, chronic diarrhea, traumatic injury, alopecia areata, clavus, etc.

Sang Ji Sheng, with bitter and sweet taste and neutral nature, enters liver and kidney meridians. Herba Taxilli has effects of nourishing liver and kidney, strengthening tendons and bones, dispelling pathogenic wind and removing dampness, and preventing miscarriage, and can be used for treating rheumatalgia, soreness of waist and knees, myasthenia of bones and muscles, metrorrhagia, menorrhagia, pregnant hemorrhage, threatened abortion, and hypertension.

Tribulus terrestris, generally indicated as Tribulus terrestris, mild in nature, pungent and bitter in flavor, with slight toxicity, entering liver meridian. Fructus Atriplicis Sibiricae has effects of suppressing hyperactive liver, resolving stagnation, promoting blood circulation, dispelling pathogenic wind, improving eyesight, and relieving itching, and can be used for treating headache, giddiness, chest and hypochondrium distending pain, breast closed mastitis, conjunctival congestion, nebula, rubella, and pruritus.

Ku Shen is bitter in taste and cold in nature, and enters heart, liver, stomach, large intestine and bladder meridians. Radix Sophorae Flavescentis has effects of clearing heat, eliminating dampness, killing parasite, and promoting diuresis, and can be used for treating dysentery, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pudendal pruritus, eczema, skin pruritus, scabies, leprosy, and trichomonas vaginitis.

Ledebouriella root, radix Saposhnikoviae, pungent and sweet in flavor, warm in nature, enters bladder, spleen and liver meridians. Radix Saposhnikoviae has effects in dispelling pathogenic wind, relieving exterior syndrome, eliminating dampness, relieving pain, and relieving spasm, and can be used for treating exogenous exterior syndrome, rubella pruritus, rheumatalgia, tetanus, and spleen deficiency.

Bombyx Batryticatus, xin Xian, ping, enters liver, lung and stomach meridians. Bombyx Batryticatus has effects of dispelling pathogenic wind, relieving spasm, eliminating phlegm and resolving hard mass, and can be used for treating apoplexy, epilepsy, headache, laryngopathy, pharyngitis, lymphoid tuberculosis, urticaria, erysipelas, and mastitis.

Cicada slough, sweet and salty in flavor, cool in nature, enters lung and liver meridians. Periostracum Cicadae has effects of dispelling pathogenic wind and heat, relieving sore throat, promoting eruption, improving eyesight, eliminating nebula, calming endogenous wind and relieving spasm, and can be used for treating wind-heat type common cold, early stage epidemic febrile disease, pharyngalgia, hoarseness, measles without adequate eruption, pruritus, conjunctival congestion, nebula, acute and chronic infantile convulsion, tetanus syndrome, and infantile night cry.

Huang Qi is sweet in flavor and warm in nature, and enters lung and spleen meridians. Radix astragali has effects of invigorating qi, consolidating superficial resistance, promoting diuresis, expelling pus, healing sore and promoting granulation, and can be used for treating qi deficiency, debilitation, anorexia, loose stool, collapse of middle-warmer energy, chronic diarrhea, rectocele, hematochezia metrorrhagia, superficial deficiency spontaneous perspiration, edema due to qi deficiency, superficial infection, ulcer, intractable ulcer, blood deficiency flaccidity, internal heat, and diabetes.

Dang Gui is sweet, pungent and warm in flavor, and enters liver, heart and spleen meridians. Radix Angelicae sinensis has effects in replenishing blood, promoting blood circulation, regulating menstruation, relieving pain, moistening dryness, and smoothing intestine, and can be used for treating blood deficiency syndrome, menoxenia, amenorrhea, dysmenorrhea, abdominal mass, metrorrhagia, abdominal pain due to deficiency cold, flaccidity, numbness of skin, constipation, dysentery, carbuncle, suppurative sore, and traumatic injury.

Agrimony, being neutral in nature, bitter and astringent in taste, enters heart and liver meridians. Herba et Gemma Agrimoniae has effects of astringing to stop bleeding, preventing malaria, stopping dysentery, and removing toxic substance, and can be used for treating hemoptysis, hematemesis, metrorrhagia, malaria, dysentery with bloody stool, overstrain wound, carbuncle, sore, pruritus vulvae, and leukorrhagia.

Dan Shen is bitter and slightly cold, entering heart and liver meridians. The salvia miltiorrhiza removes stasis and relieves pain, activates blood and stimulates the menstrual flow, clears away the heart fire and relieves restlessness. Can be used for treating menoxenia, amenorrhea, dysmenorrhea, scar, abdominal mass, chest pain, abdominal pain, arthralgia due to heat, pyocutaneous disease, vexation, insomnia, hepatosplenomegaly, and angina pectoris.

Rhodiola root, radix Rhodiolae, neutral in nature, sweet and bitter in flavor, enters lung meridian and heart meridian. Radix Rhodiolae has effects of benefiting qi, activating blood circulation, dredging collaterals and relieving asthma, and can be used for treating qi deficiency and blood stasis, thoracic obstruction, cardialgia, apoplexy, hemiplegia, listlessness and asthma.

The invention has the positive and beneficial effects that:

1. the traditional Chinese medicine shampoo disclosed by the invention adopts natural traditional Chinese medicine raw materials, is simple in preparation method, wide in raw material medicine source, low in cost, free of toxic and side effects, and suitable for long-term use by poliosis patients.

2. The traditional Chinese medicine shampoo provided by the invention is scientific and reasonable in compatibility and formula, each raw medicinal material has different functions and supplements each other, has good curative effects of tonifying qi and nourishing blood, tonifying kidney and blackening hair, dispelling wind and eliminating dampness and removing dirt, has a good treatment effect on white hair and scalp itching, and has few adverse reactions during medication.

Detailed Description

The present invention will be further described with reference to the following examples, but the embodiments of the present invention are not limited thereto. The experimental procedures used in the following examples are all conventional procedures unless otherwise specified.

Example 1

Taking 30g of cacumen biotae, 15g of prepared fleece flower root, 10g of ginger, 15g of glossy privet fruit, 15g of eclipta alba, 15g of garden balsam stem, 15g of cortex dictamni, 15g of fructus kochiae, 15g of prepared radix stemonae, 10g of rhizoma drynariae, 30g of loranthus parasiticus, 15g of tribulus terrestris, 15g of radix sophorae flavescentis, 6g of radix sileris, 10g of white muscardine silkworm, 10g of periostracum cicadae, 30g of radix astragali, 20g of angelica, 30g of hairyvein agrimonia herb and bud, 15g of radix salviae and 20g of rhodiola rosea, adding 1L of distilled water for decocting, filtering and concentrating to prepare 0.5L of traditional Chinese medicine extracting solution. Respectively taking 50g of tea bran, 20g of rice, 20g of glutinous rice, 30g of red yeast rice and 50g of masson pine needle, fully mixing the tea bran, the rice, the glutinous rice and the red yeast rice with the traditional Chinese medicine extracting solution, fermenting for 3 weeks at room temperature, filtering, boiling for sterilization, adding pharmaceutically acceptable auxiliary materials into the fermentation liquor, and finally preparing the traditional Chinese medicine shampoo containing 30% of amino acid foaming agent LS-30, 0.5% of polyquaternium-10, 6% of amino acid humectant NMF-50, 6% of glycerol, 3.5% of thickener PEG6000 and 0.5% of antibacterial agent phenoxyethanol to obtain the traditional Chinese medicine shampoo 1.

Example 2

Taking 15g of cacumen biotae, 15g of prepared fleece flower root, 10g of ginger, 20g of glossy privet fruit, 20g of eclipta alba, 20g of garden balsam stem, 15g of cortex dictamni, 15g of fructus kochiae, 15g of prepared radix stemonae, 10g of rhizoma drynariae, 30g of loranthus parasiticus, 15g of tribulus terrestris, 15g of radix sophorae flavescentis, 6g of radix sileris, 10g of white muscardine silkworm, 10g of periostracum cicadae, 30g of radix astragali, 20g of angelica, 30g of hairyvein agrimonia herb and bud, 15g of radix salviae and 20g of rhodiola rosea, adding 1L of distilled water for decocting, filtering and concentrating to prepare 0.5L of traditional Chinese medicine extracting solution. Respectively taking 50g of tea bran, 20g of rice, 20g of glutinous rice, 30g of red yeast rice and 50g of masson pine needle, fully mixing the tea bran, the rice, the glutinous rice and the red yeast rice with the traditional Chinese medicine extracting solution, fermenting for 3 weeks at room temperature, filtering, boiling for sterilization, adding pharmaceutically acceptable auxiliary materials into the fermentation liquor, and finally preparing the traditional Chinese medicine shampoo containing 30% of amino acid foaming agent LS-30, 0.5% of polyquaternium-10, 6% of amino acid humectant NMF-50, 6% of glycerol, 3.5% of thickener PEG6000 and 0.5% of antibacterial agent phenoxyethanol to obtain the traditional Chinese medicine shampoo 2.

Example 3

Taking 15g of cacumen biotae, 15g of radix polygoni multiflori preparata, 10g of ginger, 15g of glossy privet fruit, 15g of eclipta alba, 15g of garden balsam stem, 20g of cortex dictamni, 20g of fructus kochiae, 20g of radix stemonae preparata, 10g of rhizoma drynariae, 30g of loranthus parasiticus, 15g of tribulus terrestris, 15g of radix sophorae flavescentis, 6g of radix sileris, 10g of white muscardine silkworm, 10g of periostracum cicadae, 30g of radix astragali, 20g of angelica, 30g of hairyvein agrimonia herb and bud, 15g of radix salviae and 20g of rhodiola rosea, adding 1L of distilled water for decocting, filtering and concentrating to prepare 0.5L of traditional Chinese medicine extracting solution. Respectively taking 50g of tea bran, 20g of rice, 20g of glutinous rice, 30g of red yeast rice and 50g of masson pine needle, fully mixing the tea bran, the rice, the glutinous rice and the red yeast rice with the traditional Chinese medicine extracting solution, fermenting for 3 weeks at room temperature, filtering, boiling for sterilization, adding pharmaceutically acceptable auxiliary materials into the fermentation liquor, and finally preparing the traditional Chinese medicine shampoo containing 30% of amino acid foaming agent LS-30, 0.5% of polyquaternium-10, 6% of amino acid humectant NMF-50, 6% of glycerol, 3.5% of thickener PEG6000 and 0.5% of antibacterial agent phenoxyethanol to obtain the traditional Chinese medicine shampoo 3.

Example 4

Taking 15g of cacumen biotae, 15g of prepared fleece-flower root, 10g of ginger, 15g of glossy privet fruit, 15g of eclipta alba, 15g of garden balsam stem, 15g of cortex dictamni, 15g of fructus kochiae, 15g of prepared radix stemonae, 10g of rhizoma drynariae, 30g of loranthus parasiticus, 20g of tribulus terrestris, 20g of radix sophorae flavescentis, 6g of radix sileris, 10g of white muscardine silkworm, 10g of periostracum cicadae, 30g of astragalus membranaceus, 20g of angelica sinensis, 30g of hairyvein agrimonia herb and bud, 20g of salvia miltiorrhiza and 20g of rhodiola rosea, adding 1L of distilled water for decocting, filtering and concentrating to prepare 0.5L of traditional Chinese medicine extracting solution. Respectively taking 50g of tea bran, 20g of rice, 20g of glutinous rice, 30g of red yeast rice and 50g of masson pine needle, fully mixing the tea bran, the rice, the glutinous rice and the red yeast rice with the traditional Chinese medicine extracting solution, fermenting for 3 weeks at room temperature, filtering, boiling for sterilization, adding pharmaceutically acceptable auxiliary materials into the fermentation liquor, and finally preparing the traditional Chinese medicine shampoo containing 30% of amino acid foaming agent LS-30, 0.5% of polyquaternium-10, 6% of amino acid humectant NMF-50, 6% of glycerol, 3.5% of thickener PEG6000 and 0.5% of antibacterial agent phenoxyethanol to obtain the traditional Chinese medicine shampoo 4.

Example 5

Taking 15g of cacumen biotae, 15g of radix polygoni multiflori preparata, 15g of ginger, 15g of glossy privet fruit, 15g of eclipta alba, 15g of garden balsam stem, 15g of cortex dictamni, 15g of fructus kochiae, 15g of radix stemonae preparata, 10g of rhizoma drynariae, 30g of loranthus parasiticus, 15g of tribulus terrestris, 15g of radix sophorae flavescentis, 6g of radix sileris, 15g of white muscardine silkworm, 15g of periostracum cicadae, 30g of radix astragali, 20g of angelica, 30g of hairyvein agrimonia herb and bud, 15g of radix salviae and 20g of rhodiola rosea, adding 1L of distilled water for decocting, filtering and concentrating to prepare 0.5L of traditional Chinese medicine extracting solution. Respectively taking 50g of tea bran, 20g of rice, 20g of glutinous rice, 30g of red yeast rice and 50g of masson pine needle, fully mixing the tea bran, the rice, the glutinous rice and the red yeast rice with the traditional Chinese medicine extracting solution, fermenting for 3 weeks at room temperature, filtering, boiling for sterilization, adding pharmaceutically acceptable auxiliary materials into the fermentation liquor, and finally preparing the traditional Chinese medicine shampoo containing 30% of amino acid foaming agent LS-30, 0.5% of polyquaternium-10, 6% of amino acid humectant NMF-50, 6% of glycerol, 3.5% of thickener PEG6000 and 0.5% of antibacterial agent phenoxyethanol to obtain the traditional Chinese medicine shampoo 5.

Unless otherwise specified, the herbal shampoos of examples 1 to 5 used in test examples 1 to 3 of the present invention were all herbal extract fermentation liquors obtained by mixing herbal extracts with fermentation adjuvants according to the preparation methods of examples 1 to 5 and then fermenting, and did not contain amino acid foaming agents, polyquaternium salts, amino acid moisturizers, glycerin, thickeners, and antibacterial agents.

Test example 1 test of the effect of the shampoo of the present invention on the proliferation activity of melanoma cells and the content of melanin

1. Test method

1.1 culture of mouse B16 melanoma cells

DMEM medium (10U/mL penicillin, 100. Mu.g/mL streptomycin) containing 10% calf serum was prepared, the incubator was set at 37 ℃ and the content of CO was 5% ₂ Culturing cells, digesting with 200 μ l of 0.25% trypsin when the cells are in a near-confluent state, subpackaging, renewing the culture medium, and passaging once every three days.

1.2 determination of proliferative Activity of B16 melanoma cells

The proliferation activity of B16 melanoma cells was determined by MTT assay. Cell digestion in logarithmic growth phase adjusted to 5 x 10 ⁴ Per mL, 100. Mu.l was inoculated into a 96-well plate, the culture conditions were set at 37 ℃, 5% ₂ Incubate for 24 hours. In the invention, 100 mul of the fermentation liquor of the traditional Chinese medicine extract prepared in the embodiment 1-5 is added into each hole of 1-5 groups of the traditional Chinese medicine washing hair, 3 parallel holes are arranged, the culture medium and the cells are used as blank control, and the cells are cultured in an incubator for 48h and then observed under an inverted microscope. Mu.l of 5mg/mL MTT was added, after 4h incubation in an incubator, the 96-well plate was removed and the medium aspirated, 100. Mu.l of lysate was added and shaken for half an hour to dissolve the crystals sufficiently, and the 490nm light absorption was measured. Computing IC using graphpad prism software ₅₀ And recording and analyzing the experimental result.

1.3 melanin content determination (NaOH lysis method, unless otherwise specified, test methods are 1.2)

Inoculating cells by the same method, after the drug acts for 48h, removing the supernatant, washing with PBS, adding 100 μ L of 1mol/L NaOH, performing water bath lh at 37 ℃, detecting the absorbance value at 490nm by an enzyme-labeling instrument, and expressing the melanin content by the absorbance value.

2. Test results

The results of the effects of the shampoo of the present invention on the proliferation of B16 melanoma cells and melanogenesis are shown in Table 1, wherein the survival rate of the blank control group is 100%, and the promotion of the test group is higher than 100%.

TABLE 1 Effect of the shampoo of the present invention on cell proliferation and melanogenesis

Group of	Cell proliferation Rate (%)	Melanogenesis (%)
			Shampoo 1 group of the invention	188	174
Shampoo 2 groups of the invention	153	144
			Shampoo 3 groups of the invention	148	139
Invention shampoo 4 groups	126	131
			Shampoo 5 groups of the invention	132	142

From the above table 1, it can be seen that the proliferation rate of B16 melanoma cells and the melanogenesis rate of the traditional Chinese medicine shampoo 1-5 groups are higher than 100% of those of the control group, and it is confirmed that the traditional Chinese medicine shampoo has a significant effect on blacking hair.

Test example 2 test of the effect of the hair washing liquid of the present invention on the hair blackening effect of white hair model mice

1. Test method

1.1 construction of white hair mouse model

Shaving a C57BL/6 mouse, starting modeling after 7 days, smearing 2.5% hydroquinone outside the mouse, wherein the smearing amount is 1mL each time, the smearing is performed twice a day, the smearing is performed once in the morning and afternoon, the smearing is performed continuously for 28 days, and the successfully modeled mouse with a whitened hair area accounting for more than 80% of an experimental area is taken as a subsequent test object.

1.2 dosing regimens

The prepared white hair mice are divided into a model group and 1-5 groups of the traditional Chinese medicine shampoo, 10 mice in each group are coated with normal saline, the 1-5 groups of the traditional Chinese medicine shampoo are respectively coated with the traditional Chinese medicine extract fermentation liquor prepared in the embodiment 1-5, the coating amount is 0.3mL each time, the traditional Chinese medicine extract fermentation liquor is coated twice a day, and the traditional Chinese medicine extract fermentation liquor is coated once in the morning and afternoon for 28 days continuously. After the test, the new hair was shaved off by using a razor, and the effect of improving the white hair of the mice in each test group was scored according to the following criteria: the '4 th' is the newly grown hair in the observation area is black and black without white hair; the 3 th mark is that the new hair in the observation area is black and is mixed with gray hair; the '2 marks' is the grey hair mixed with white hair of the newly grown hair in the observation area; the 1 point is that most of the hair in the observation area is white and is mixed with a little gray; "0 point" is all white and has no black hair.

2. Test results

At the end of the test, the hair blackening score of the mice in each test group after using the shampoo of the present invention is shown in table 2 below.

Table 2 mouse hair darkening score

Group of	Scoring
		Model set	1.2
Shampoo 1 group of the invention	3.8
		Shampoo 2 groups of the invention	3.2
Shampoo 3 groups of the invention	2.8
		Shampoo of the invention 4 groups	2.7
Shampoo 5 groups of the invention	3.0

As can be seen from table 2 above, compared with the model group, the hair blackening score of mice in the groups 1 to 5 of the traditional Chinese medicine shampoo is significantly increased (the difference has statistical significance), and the traditional Chinese medicine shampoo has a significant effect on hair blackening. It is noted that the hair-blackening effect of the group 1 of the Chinese medicinal shampoo of the present invention is the most excellent, resulting in unexpected technical effects.

Test example 3 test of the effect of the shampoo of the present invention on the treatment of skin itch of mice

1. Test method

The experimental mice were randomly divided into 6 groups (blank control group, chinese medicinal washing water of the present invention 1-5 groups), and 5 mice per group. The right and back buttocks of each group of mice were shaved 24h before the experiment, and the area was about 1cm ² The amount of the fermentation broth of the Chinese herbal medicine extract prepared in examples 1 to 5 applied at the 1 st time is the amount of cotton swabs taken at one time. The hair shaving part of the mouse is abraded by No. 0 abrasive paper on the same day of the experiment, the abrasion degree is determined by damaging epidermis, not damaging dermis and slightly oozing blood of skin, and the area is about 1cm ² Topically applying the corresponding medicine for 1 time, and dripping 0.01% histamine phosphate at the wound surface 10min after the last application, wherein the concentration of the medicine is 0.02%, 0.03%, 0.04%, and 0.05% every 3min, each time is 0.05mL, and observing after dripping each concentrationAnd (3) judging whether the mouse licks the back of the right foot back or not within 3min, if the back of the right foot back is not licked, continuing to dropwise add the histamine phosphate solution with the next higher concentration until the back of the right foot back is licked, and taking the total amount of the histamine phosphate given at the moment as an itching threshold value.

2. Test results

The itch-causing threshold value of the traditional Chinese medicine shampoo for the skin itch of the mice in each test group is shown in the following table 3.

TABLE 3 Effect of the antipruritic effect of the shampoo according to the invention

Group of	Scratchiness threshold (mean of total histamine phosphate amount)/μ g
		Model set	76±19.5
Shampoo 1 group of the invention	235±22.4
		Shampoo 2 groups of the invention	190±35.9
Shampoo 3 groups of the invention	181±30.1
		Invention shampoo 4 groups	207±24.6
Shampoo 5 groups of the invention	172±17.9

From the above table 3, compared with the model group, the itching threshold of the mice in the groups 1 to 5 of the traditional Chinese medicine shampoo is obviously increased (the difference has statistical significance), and the traditional Chinese medicine shampoo has an obvious effect on treating skin itch such as scalp. It is noted that the treatment effect of the group 1 of the traditional Chinese medicine shampoo of the invention is optimal, resulting in unexpected technical effects.

It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modifications, equivalents, improvements and the like which are made without departing from the spirit and scope of the present invention shall be included in the protection scope of the present invention.

Claims

1. The traditional Chinese medicine shampoo is characterized by being prepared by mixing a traditional Chinese medicine extracting solution and fermentation auxiliary materials, then fermenting, and then adding pharmaceutically acceptable auxiliary materials, wherein the traditional Chinese medicine extracting solution is prepared by 10-50 parts by weight of cacumen biotae, 5-25 parts by weight of radix polygoni multiflori preparata, 1-20 parts by weight of ginger, 5-25 parts by weight of glossy privet fruit, 5-25 parts by weight of eclipta alba, 5-25 parts by weight of garden balsam stem, 5-25 parts by weight of cortex dictamni, 5-25 parts by weight of broom cypress fruit, 5-25 parts by weight of radix stemonae preparata, 1-20 parts by weight of rhizoma drynariae, 10-50 parts by weight of parasitic loranthus, 5-25 parts by weight of tribulus terrestris, 5-25 parts by weight of radix sophorae flavescentis, 1-15 parts by weight of radix sileris, 1-20 parts by weight of white muscardine silkworm, 1-20 parts by weight of cicada slough, 10-50 parts by weight of radix astragali, 5-35 parts by weight of angelica sinensis, 10-50 parts by weight of agrimony, 5-25 parts by weight of radix salviae and 5-35 parts by weight of rhodiola rosea; the fermentation auxiliary materials comprise 40-60 parts by weight of tea bran, 10-30 parts by weight of rice, 10-30 parts by weight of sticky rice, 20-40 parts by weight of red yeast rice and 40-60 parts by weight of masson pine needle.

2. The traditional Chinese medicine shampoo as claimed in claim 1, wherein the traditional Chinese medicine extracting solution is prepared from 20-40 parts by weight of cacumen biotae, 10-20 parts by weight of radix polygoni multiflori preparata, 5-15 parts by weight of ginger, 10-20 parts by weight of glossy privet fruit, 10-20 parts by weight of eclipta alba, 10-20 parts by weight of speranskia tuberculata, 10-20 parts by weight of cortex dictamni, 10-20 parts by weight of fructus kochiae, 10-20 parts by weight of radix stemonae preparata, 5-15 parts by weight of rhizoma drynariae, 20-40 parts by weight of parasitic loranthus, 10-20 parts by weight of tribulus terrestris, 10-20 parts by weight of radix sophorae flavescentis, 1-10 parts by weight of radix sileris, 5-15 parts by weight of white muscardine silkworm, 5-15 parts by weight of periostracum cicada, 20-40 parts by weight of radix astragali, 10-30 parts by weight of angelica sinensis, 20-40 parts by weight of hairyvein agrimony, 10-20 parts by weight of radix salviae and 10-30 parts by weight of rhodiola rosea.

3. The traditional Chinese medicine shampoo as claimed in claim 2, wherein the traditional Chinese medicine extracting solution is prepared from 30 parts by weight of cacumen biotae, 15 parts by weight of radix polygoni multiflori preparata, 10 parts by weight of ginger, 15 parts by weight of glossy privet fruit, 15 parts by weight of eclipta alba, 15 parts by weight of garden balsam stem, 15 parts by weight of cortex dictamni, 15 parts by weight of fructus kochiae, 15 parts by weight of radix stemonae preparata, 10 parts by weight of rhizoma drynariae, 30 parts by weight of parasitic loranthus, 15 parts by weight of fructus tribuli, 15 parts by weight of radix sophorae flavescentis, 6 parts by weight of radix sileris, 10 parts by weight of silkworm larva, 10 parts by weight of periostracum cicada, 30 parts by weight of radix astragali, 20 parts by weight of angelica sinensis, 30 parts by weight of hairyvein agrimony, 15 parts by weight of radix salviae and 20 parts by weight of rhodiola rosea.

4. The traditional Chinese medicine shampoo as claimed in claim 1, wherein the fermentation auxiliary materials comprise 50 parts by weight of tea bran, 20 parts by weight of rice, 20 parts by weight of sticky rice, 30 parts by weight of red yeast rice and 50 parts by weight of masson pine needles.

5. The traditional Chinese medicine shampoo as claimed in claim 1, wherein the pharmaceutically acceptable auxiliary materials comprise one or more of an amino acid foaming agent, a polyquaternium, an amino acid humectant, glycerin, a thickener and an antibacterial agent.

6. The preparation method of the traditional Chinese medicine shampoo as in any one of claims 1 to 5, comprising the following steps:

(1) Taking cacumen biotae, radix polygoni multiflori preparata, ginger, glossy privet fruit, eclipta alba, garden balsam stem, cortex dictamni, fructus kochiae, radix stemonae preparata, rhizoma drynariae, parasitic loranthus, tribulus terrestris, radix sophorae flavescentis, radix sileris, silkworm larva, periostracum cicadae, radix astragali, angelica sinensis, hairyvein agrimony, radix salviae miltiorrhizae and rhodiola rosea according to the corresponding weight parts, adding distilled water with the weight being 2-5 times of that of the traditional Chinese medicines, decocting, filtering, concentrating until half of the volume of the distilled water is added, and preparing a traditional Chinese medicine extracting solution;

(2) And (2) respectively and fully mixing the tea bran, the rice, the sticky rice, the red yeast rice and the masson pine needles in corresponding weight parts with the traditional Chinese medicine extracting solution in the step (1), fermenting at room temperature for 3 weeks, filtering, boiling for sterilization, and adding the amino acid foaming agent, the polyquaternium, the amino acid humectant, the glycerol, the thickening agent and the antibacterial agent in the formula.

7. Use of the traditional Chinese medicine shampoo as defined in any one of claims 1 to 5 in the preparation of a hair-blacking product.

8. Use of the traditional Chinese medicine shampoo as defined in any one of claims 1-5 in preparation of a product for improving scalp itching.