CN114761084B - 具有铰链结构域的Notch受体 - Google Patents

具有铰链结构域的Notch受体 Download PDF

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CN114761084B
CN114761084B CN202080080098.XA CN202080080098A CN114761084B CN 114761084 B CN114761084 B CN 114761084B CN 202080080098 A CN202080080098 A CN 202080080098A CN 114761084 B CN114761084 B CN 114761084B
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CN114761084A (zh
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K·T·罗伊鲍尔
R·刘
I·朱
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University of California San Diego UCSD
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    • C07K16/18—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IG], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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CN202080080098.XA 2019-09-24 2020-09-23 具有铰链结构域的Notch受体 Active CN114761084B (zh)

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US201962905263P 2019-09-24 2019-09-24
US62/905,251 2019-09-24
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PCT/US2020/052327 WO2021061862A1 (en) 2019-09-24 2020-09-23 Notch receptors with hinge domain

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AU2020355031A1 (en) 2019-09-24 2022-05-19 The Regents Of The University Of California Notch receptors with hinge domain
CN115666726A (zh) * 2020-04-09 2023-01-31 加利福尼亚大学董事会 具有铰链结构域的人源化Notch受体
CN117255799A (zh) * 2021-03-23 2023-12-19 加利福尼亚大学董事会 用于定制抗原诱导的转录调控的合成膜间蛋白水解受体
JP2024537991A (ja) 2021-10-14 2024-10-18 アーセナル バイオサイエンシズ インコーポレイテッド 共発現されるｓｈＲＮＡと論理ゲートシステムとを有する免疫細胞
EP4444748A4 (en) * 2021-12-07 2025-12-24 Univ California SYNTHETIC CYTOKINE CIRCUITS TO PROMOTE INFILTRATION AND ELIMINATION OF SOLID TUMORS EXCLUDED FROM THE IMMUNE SYSTEM BY MODIFIED IMMUNE CELLS
CN114349840B (zh) * 2021-12-13 2024-07-12 中山大学肿瘤防治中心（中山大学附属肿瘤医院、中山大学肿瘤研究所） 一种融合蛋白及其制备方法与应用
CN114621929B (zh) * 2021-12-21 2023-05-30 河南省肿瘤医院 一种抗肿瘤树突状细胞及其制备方法、表达载体及应用
AU2023273025A1 (en) * 2022-05-16 2024-11-28 The Regents Of The University Of California T cell activation responsive constructs for enhanced car-t cell therapy
IL322949A (en) 2023-03-03 2025-10-01 Arsenal Biosciences Inc Systems targeting PSMA and CA9
WO2024249416A2 (en) * 2023-06-01 2024-12-05 Vanderbilt University Engineered cells to detect and respond to amyloid beta peptides
CN117304343B (zh) * 2023-10-11 2024-05-07 北京景达生物科技有限公司 Gpc3靶向的car-nk细胞的制备及其应用
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