BR112022005283A2 - Receptores notch com domínio de dobradiça - Google Patents

Receptores notch com domínio de dobradiça

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Publication number
BR112022005283A2
BR112022005283A2 BR112022005283A BR112022005283A BR112022005283A2 BR 112022005283 A2 BR112022005283 A2 BR 112022005283A2 BR 112022005283 A BR112022005283 A BR 112022005283A BR 112022005283 A BR112022005283 A BR 112022005283A BR 112022005283 A2 BR112022005283 A2 BR 112022005283A2
Authority
BR
Brazil
Prior art keywords
receptors
notch
receivers
nucleic acids
hinge domain
Prior art date
Application number
BR112022005283A
Other languages
English (en)
Inventor
T Roybal Kole
Liu Raymond
Zhu Iowis
Original Assignee
Univ California
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Publication date
Application filed by Univ California filed Critical Univ California
Publication of BR112022005283A2 publication Critical patent/BR112022005283A2/pt

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    • A61K35/00—Medicinal preparations containing materials or reaction products thereof with undetermined constitution
    • A61K35/12—Materials from mammals; Compositions comprising non-specified tissues or cells; Compositions comprising non-embryonic stem cells; Genetically modified cells
    • A61K35/14—Blood; Artificial blood
    • A61K35/17—Lymphocytes; B-cells; T-cells; Natural killer cells; Interferon-activated or cytokine-activated lymphocytes
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/461—Cellular immunotherapy characterised by the cell type used
    • A61K39/4611—T-cells, e.g. tumor infiltrating lymphocytes [TIL], lymphokine-activated killer cells [LAK] or regulatory T cells [Treg]
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    • A61K39/4631—Chimeric Antigen Receptors [CAR]
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464411—Immunoglobulin superfamily
    • A61K39/464412—CD19 or B4
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464402—Receptors, cell surface antigens or cell surface determinants
    • A61K39/464416—Receptors for cytokines
    • A61K39/464417—Receptors for tumor necrosis factors [TNF], e.g. lymphotoxin receptor [LTR], CD30
    • A—HUMAN NECESSITIES
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    • A61K39/46—Cellular immunotherapy
    • A61K39/464—Cellular immunotherapy characterised by the antigen targeted or presented
    • A61K39/4643—Vertebrate antigens
    • A61K39/4644—Cancer antigens
    • A61K39/464466—Adhesion molecules, e.g. NRCAM, EpCAM or cadherins
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    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/46—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates
    • C07K14/47—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals
    • C07K14/4701—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans from vertebrates from mammals not used
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    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
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    • C07K14/70521—CD28, CD152
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    • C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
    • C07K14/70578—NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
    • C—CHEMISTRY; METALLURGY
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    • C07—ORGANIC CHEMISTRY
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    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2878—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the NGF-receptor/TNF-receptor superfamily, e.g. CD27, CD30, CD40, CD95
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    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
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    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2239/00—Indexing codes associated with cellular immunotherapy of group A61K39/46
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    • C07K2317/00—Immunoglobulins specific features
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    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
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    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
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    • C07K2319/70—Fusion polypeptide containing domain for protein-protein interaction
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    • C07K2319/715—Fusion polypeptide containing domain for protein-protein interaction containing domain for transcriptional activaation, e.g. VP16 containing a domain for ligand dependent transcriptional activation, e.g. containing a steroid receptor domain
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Abstract

RECEPTORES NOTCH COM DOMÍNIO DE DOBRADIÇA. A presente descrição refere-se de modo geral a, inter alia, uma classe de receptores manipulados para modular a regulação da transcrição de uma maneira dependente do ligante. Particularmente, os receptores, mesmo que derivados de Notch, não requerem as regiões regulatórias negativas de Notch, previamente consideradas serem essenciais para o funcionamento dos receptores. Adicionalmente, os receptores descritos aqui incorporam um domínio de oligomerização extracelular para promover a formação de oligômero dos receptores quiméricos. A descrição também fornece composições e métodos uteis para produção de tais receptores, ácidos nucleicos que codificam os mesmos, células hospedeiras geneticamente modificadas com os ácidos nucleicos, assim como métodos para modular uma atividade de uma célula e/ou para o tratamento de várias condições tais como cânceres.
BR112022005283A 2019-09-24 2020-09-23 Receptores notch com domínio de dobradiça BR112022005283A2 (pt)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962905263P 2019-09-24 2019-09-24
US201962905251P 2019-09-24 2019-09-24
PCT/US2020/052327 WO2021061862A1 (en) 2019-09-24 2020-09-23 Notch receptors with hinge domain

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BR112022005283A2 true BR112022005283A2 (pt) 2022-08-16

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BR112022005283A BR112022005283A2 (pt) 2019-09-24 2020-09-23 Receptores notch com domínio de dobradiça

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US (3) US11202801B2 (pt)
EP (1) EP4034252A4 (pt)
JP (1) JP2022548796A (pt)
KR (1) KR20220087454A (pt)
CN (1) CN114761084B (pt)
AU (1) AU2020355031A1 (pt)
BR (1) BR112022005283A2 (pt)
CA (1) CA3155661A1 (pt)
IL (2) IL307609A (pt)
WO (1) WO2021061862A1 (pt)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
IL307609A (en) 2019-09-24 2023-12-01 Univ California Notch receptors with hinge area
EP4132659A1 (en) * 2020-04-09 2023-02-15 The Regents Of The University Of California Humanized notch receptors with hinge domain
CN114621929B (zh) * 2021-12-21 2023-05-30 河南省肿瘤医院 一种抗肿瘤树突状细胞及其制备方法、表达载体及应用
WO2023225482A2 (en) * 2022-05-16 2023-11-23 The Regents Of The University Of California T cell activation responsive constructs for enhanced car-t cell therapy
CN117304343B (zh) * 2023-10-11 2024-05-07 北京景达生物科技有限公司 Gpc3靶向的car-nk细胞的制备及其应用

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* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DK0781095T3 (da) * 1994-08-02 2003-06-23 Gen Hospital Corp Celler der bærer CD4 lokkeduereceptorer og beslægtede molekyler og fremgangsmåder
WO2016138034A1 (en) * 2015-02-24 2016-09-01 The Regents Of The University Of California Binding-triggered transcriptional switches and methods of use thereof
CN109843929A (zh) * 2016-08-23 2019-06-04 加利福尼亚大学董事会 蛋白水解可切割的嵌合多肽及其使用方法
WO2018132427A1 (en) * 2017-01-10 2018-07-19 The General Hospital Corporation Targeted t cells with cytotoxicity toward immunosuppressive cells
US10724680B2 (en) * 2017-07-06 2020-07-28 Robert Anthony Benson, SR. Personal device holder
AU2018352984B2 (en) * 2017-10-18 2024-02-01 Precigen, Inc. Polypeptide compositions comprising spacers
IL307609A (en) 2019-09-24 2023-12-01 Univ California Notch receptors with hinge area

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IL291558B1 (en) 2023-11-01
EP4034252A4 (en) 2023-11-08
AU2020355031A1 (en) 2022-05-19
US20220133797A1 (en) 2022-05-05
US20240075062A1 (en) 2024-03-07
US11202801B2 (en) 2021-12-21
IL307609A (en) 2023-12-01
WO2021061862A1 (en) 2021-04-01
IL291558A (en) 2022-05-01
JP2022548796A (ja) 2022-11-21
CN114761084B (zh) 2023-10-27
KR20220087454A (ko) 2022-06-24
US20210268024A1 (en) 2021-09-02
IL291558B2 (en) 2024-03-01
US11617766B2 (en) 2023-04-04
EP4034252A1 (en) 2022-08-03
CN114761084A (zh) 2022-07-15
CA3155661A1 (en) 2021-04-01

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