CN114733586B - 一种微粒子流动聚焦装置及方法 - Google Patents

一种微粒子流动聚焦装置及方法 Download PDF

Info

Publication number
CN114733586B
CN114733586B CN202210228904.4A CN202210228904A CN114733586B CN 114733586 B CN114733586 B CN 114733586B CN 202210228904 A CN202210228904 A CN 202210228904A CN 114733586 B CN114733586 B CN 114733586B
Authority
CN
China
Prior art keywords
flow
sorting
focusing
flow channel
particles
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Active
Application number
CN202210228904.4A
Other languages
English (en)
Chinese (zh)
Other versions
CN114733586A (zh
Inventor
陈华英
徐正
陈思远
陈震林
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Zhuhai Ontario Technology Co ltd
Original Assignee
Zhuhai Ontario Technology Co ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Zhuhai Ontario Technology Co ltd filed Critical Zhuhai Ontario Technology Co ltd
Priority to CN202210228904.4A priority Critical patent/CN114733586B/zh
Priority to PCT/CN2022/085184 priority patent/WO2023168775A1/fr
Publication of CN114733586A publication Critical patent/CN114733586A/zh
Application granted granted Critical
Publication of CN114733586B publication Critical patent/CN114733586B/zh
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

Images

Classifications

    • BPERFORMING OPERATIONS; TRANSPORTING
    • B01PHYSICAL OR CHEMICAL PROCESSES OR APPARATUS IN GENERAL
    • B01LCHEMICAL OR PHYSICAL LABORATORY APPARATUS FOR GENERAL USE
    • B01L3/00Containers or dishes for laboratory use, e.g. laboratory glassware; Droppers
    • B01L3/50Containers for the purpose of retaining a material to be analysed, e.g. test tubes
    • B01L3/502Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures
    • B01L3/5027Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip
    • B01L3/502761Containers for the purpose of retaining a material to be analysed, e.g. test tubes with fluid transport, e.g. in multi-compartment structures by integrated microfluidic structures, i.e. dimensions of channels and chambers are such that surface tension forces are important, e.g. lab-on-a-chip specially adapted for handling suspended solids or molecules independently from the bulk fluid flow, e.g. for trapping or sorting beads, for physically stretching molecules

Landscapes

  • Chemical & Material Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Physics & Mathematics (AREA)
  • Fluid Mechanics (AREA)
  • Dispersion Chemistry (AREA)
  • Analytical Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Hematology (AREA)
  • Clinical Laboratory Science (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Automatic Analysis And Handling Materials Therefor (AREA)
  • Apparatus Associated With Microorganisms And Enzymes (AREA)
CN202210228904.4A 2022-03-09 2022-03-09 一种微粒子流动聚焦装置及方法 Active CN114733586B (zh)

Priority Applications (2)

Application Number Priority Date Filing Date Title
CN202210228904.4A CN114733586B (zh) 2022-03-09 2022-03-09 一种微粒子流动聚焦装置及方法
PCT/CN2022/085184 WO2023168775A1 (fr) 2022-03-09 2022-04-02 Dispositif et procédé de focalisation d'écoulement de microparticules

Applications Claiming Priority (1)

Application Number Priority Date Filing Date Title
CN202210228904.4A CN114733586B (zh) 2022-03-09 2022-03-09 一种微粒子流动聚焦装置及方法

Publications (2)

Publication Number Publication Date
CN114733586A CN114733586A (zh) 2022-07-12
CN114733586B true CN114733586B (zh) 2023-05-26

Family

ID=82275921

Family Applications (1)

Application Number Title Priority Date Filing Date
CN202210228904.4A Active CN114733586B (zh) 2022-03-09 2022-03-09 一种微粒子流动聚焦装置及方法

Country Status (2)

Country Link
CN (1) CN114733586B (fr)
WO (1) WO2023168775A1 (fr)

Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110496655A (zh) * 2019-07-26 2019-11-26 北京工业大学 一种基于微流控技术的肿瘤细胞检测芯片

Family Cites Families (14)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20090052272A1 (en) * 2007-08-20 2009-02-26 Artann Laboratories, Inc. Ultrasonic stirring of liquids in small volumes
EP2646798B1 (fr) * 2010-12-03 2017-06-28 Cellply S.R.L. Microanalyse d'une fonction cellulaire
US9597692B2 (en) * 2011-08-26 2017-03-21 Imec Micro-fluidic device for sorting particles, and methods for sorting particles
CN103191791B (zh) * 2013-03-01 2014-09-10 东南大学 生物微粒高通量分选和计数检测的集成芯片系统及应用
US9618520B2 (en) * 2013-04-25 2017-04-11 Vladislav B. Bergo Microarray compositions and methods of their use
CN103341372A (zh) * 2013-07-05 2013-10-09 西北工业大学 一种用于流式细胞仪的微流控芯片结构及其制作方法
CN104195028B (zh) * 2014-08-05 2017-07-25 深圳先进技术研究院 用于对特异性细胞进行筛选的微流控芯片及细胞筛选方法
US10488321B2 (en) * 2015-03-19 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Devices and methods for high-throughput single cell and biomolecule analysis and retrieval in a microfluidic chip
JP2017219479A (ja) * 2016-06-09 2017-12-14 住友電気工業株式会社 微小粒子計測装置及び分析方法
US10391493B2 (en) * 2017-08-29 2019-08-27 Celsee Diagnostics, Inc. System and method for isolating and analyzing cells
CN108034586B (zh) * 2018-01-02 2023-09-22 清华大学深圳研究生院 一种用于单细胞捕捉和培养的微流控芯片
CN109943475A (zh) * 2019-04-12 2019-06-28 广西医科大学第一附属医院 一种微流控分选芯片及其分选系统
CN111019998A (zh) * 2019-12-26 2020-04-17 广东省医疗器械研究所 一种用于异质循环肿瘤细胞即时检测的方法及装置
CN111733074B (zh) * 2020-07-30 2020-12-04 首都医科大学附属北京友谊医院 用于循环肿瘤细胞高通量磁力分选的微流控芯片及其系统

Patent Citations (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110496655A (zh) * 2019-07-26 2019-11-26 北京工业大学 一种基于微流控技术的肿瘤细胞检测芯片

Also Published As

Publication number Publication date
WO2023168775A1 (fr) 2023-09-14
CN114733586A (zh) 2022-07-12

Similar Documents

Publication Publication Date Title
CN106413901B (zh) 用于颗粒分选的方法和设备
Chung et al. Recent advances in miniaturized microfluidic flow cytometry for clinical use
WO2010113994A1 (fr) Dispositif pour concentrer et séparer des cellules
US10351894B2 (en) Method and device for isolating cells from heterogeneous solution using microfluidic trapping vortices
US8208138B2 (en) Spiral microchannel particle separators, straight microchannel particle separators, and continuous particle separator and detector systems
CN109580323B (zh) 一种螺旋形微通道及其使用方法与串、并联安装结构
US9597692B2 (en) Micro-fluidic device for sorting particles, and methods for sorting particles
US20170299492A1 (en) Method, device and system for hydrodynamic flow focusing
JP2006220423A (ja) ゲル電極付セルソーターチップ
CN111744565B (zh) 对细胞变形性进行多通道并行检测的微流控器件及系统
CN111909828B (zh) 一种适用于循环肿瘤细胞捕获的微流控芯片
US11579073B2 (en) Microfluidic system with combined electrical and optical detection for high accuracy particle sorting and methods thereof
US20210170402A1 (en) Microparticle sorting microchip and microparticle sorting apparatus
CN111647499A (zh) 集成黏弹性和磁力的细胞多级分选微流控芯片
CN114733586B (zh) 一种微粒子流动聚焦装置及方法
KR102474060B1 (ko) 미세유체칩 유동에 의한 세포입자의 크기별 분리 장치와 방법
CN112553048A (zh) 一种细胞分选方法和芯片
CN116539484A (zh) 一种基于惯性微流控的肿瘤细胞机械特性检测装置及方法
JP2020519305A (ja) 標的細胞の検出と単離のためのMicroFACS
CN114870913B (zh) 一种集成弹性-惯性聚焦和虚拟流道的微流控器件及系统
JP2009162643A (ja) 微小粒子の送流方法及び分析方法、並びに微小粒子分析用基板
US20220355295A1 (en) Positionally Assisted Negative particle Rejection (PANR) to sort and enrich target cells of interest
CN218642732U (zh) 一种基于数字微流控技术的单细胞分选系统
WO2021090555A1 (fr) Procédé d'amorçage de micropuce pour tri de particules fines, procédé de tri de particules fines, dispositif de tri de particules fines et programme
CN219016019U (zh) 细胞流式分选装置

Legal Events

Date Code Title Description
PB01 Publication
PB01 Publication
SE01 Entry into force of request for substantive examination
SE01 Entry into force of request for substantive examination
GR01 Patent grant
GR01 Patent grant