CN114732885A - Improved composition for protecting liver and kidney, regulating immunity and improving physique and preparation method thereof - Google Patents
Improved composition for protecting liver and kidney, regulating immunity and improving physique and preparation method thereof Download PDFInfo
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Abstract
The invention discloses an improved composition for protecting liver and kidney, regulating immunity and improving physique and a preparation method thereof. The wall-broken ganoderma lucidum spore powder, the spirulina powder and the raspberry polyphenol extract are proportioned, so that the problem of drug effect reduction caused by easy oxidation of the composition is solved, meanwhile, a component-wrapped structure type is established, the technical effect of resisting oxidation of drug ingredients is improved, and the drug effect can be ensured to play a role continuously. The starch graft acrylate is added, so that the medicine has certain water retention capacity, and is favorable for quick decomposition and component absorption. The composition can meet the requirements of people with liver and kidney deficiency, low immunity, weak constitution due to long-term illness and the like on improving the physique through scientific compatibility and improvement of raw materials, and has the effects of preventing the occurrence and development of various chronic diseases, repairing damaged liver and kidney cells, improving the immunity and improving the life quality.
Description
Technical Field
The invention relates to the technical field of health-care food, in particular to an improved composition for protecting liver and kidney, regulating immunity and improving physique and a preparation method thereof.
Background
The traditional Chinese medicine considers that: most of the immune diseases are caused by the causes of deficient innate endowment, deficiency of vital qi, acquired health preservation, and weak viscera. Therefore, the regulation of immunity is mainly embodied in improving the healthy qi of the body. The healthy qi is retained in the interior, the pathogenic factors cannot dry out, and the qi must be deficient due to the pathogenic factors.
The form of air movement is called lifting in and out. The functional activities of the zang-fu organs and meridians, the interrelation and restriction of the zang-fu organs, meridians and qi, blood, yin and yang, do not depend on the ascending, descending, exiting and entering of qi movement. The normal physiological function activities of the organs and systems of the body are that the dynamic balance of the body can be maintained only when the qi movement goes up and down and goes out. Sufficient healthy qi, smooth qi movement and normal immune function.
The traditional Chinese medicine considers that the immune system is also closely related to the theory of viscera. Kidneys store essence, receive qi, govern bones, generate marrow to pass through the brain, open into ears and two yin, and bloom and erupt on hair. The kidney is the congenital root, the root of the five zang organs, the gate of life, and the bone marrow and thymus of the central immune organs in modern immunology are connected. Bone marrow is the central immune organ in the immune system and the origin of lymphocytes, so the kidneys are directly related to the source of immunocompetent cells. Kidneys store essence, store original qi, and original qi of kidneys belongs to the category of healthy qi of human body, so that the kidney qi is sufficient, the healthy qi is strong, and the immune function of the body is normal.
Therefore, by taking the treatment principle of the traditional Chinese medicine on low immunity as reference and combining with the modern pharmacological research theory, through a large amount of literature research and research, several traditional medicines are elaborately screened out to serve as core components for regulating immunity, so that the liver and the kidney are tonified, the immunity of the organism is regulated, and a better choice is provided for improving the physique. The applicant filed on 07/02/2021 a patent application with the following numbers: 202110167543.2 patent: a composition for protecting liver and kidney, regulating immunity and improving body constitution and its preparation method are provided. Although the technical effects of protecting the liver and the kidney, regulating the immunity and improving the physique are realized on the basis of the prior art, the applicant finds that the effect fed back after actual administration is lower than the expected effect.
Therefore, the applicant inspires and solves the existing problems from the use feedback of the original formula and continuously improves the compatibility of the raw materials.
Disclosure of Invention
Therefore, the invention provides an improved composition for protecting liver and kidney, regulating immunity and improving physique and a preparation method thereof, aims to overcome the defects of easy oxidation, poor stability and the like of various components in the existing preparation process, and provides the composition for protecting liver and kidney, regulating immunity and improving physique, which has the advantages of scientific formula, reasonable proportion, effective dosage, good stability, high safety and convenience in taking, and the preparation method thereof.
In order to achieve the above purpose, the invention provides the following technical scheme:
according to the first aspect of the invention, the invention provides an improved composition for protecting liver and kidney, regulating immunity and improving physique, which comprises the following components in parts by weight:
10-30 parts of astragalus extract,
5-20 parts of glossy privet fruit extract,
2-8 parts of turmeric extract,
2-5 parts of water chestnut extract,
8-15 parts of bupleurum extract,
3-6 parts of poria cocos extract,
2-6 parts of lithospermum extract,
0.5 to 1 portion of wall-broken ganoderma lucidum spore powder,
2-4 parts of spirulina powder,
1-2 parts of raspberry polyphenol extract,
2-4 parts of starch grafted acrylate.
Further, the improved composition for protecting liver and kidney, regulating immunity and improving physique comprises the following components in parts by weight:
20-25 parts of astragalus extract,
10-15 parts of glossy privet fruit extract,
4-6 parts of turmeric extract,
3-5 parts of water chestnut extract,
10-12 parts of bupleurum extract,
4-6 parts of poria cocos extract,
2-4 parts of lithospermum extract,
0.5 to 1 portion of wall-broken ganoderma lucidum spore powder,
2-3 parts of spirulina powder,
1.5-2 parts of raspberry polyphenol extract,
2.5-4 parts of starch grafted acrylate.
Further, the improved composition for protecting liver and kidney, regulating immunity and improving physique comprises the following components in parts by weight:
18 parts of astragalus extract,
12 portions of glossy privet fruit extract,
5 parts of turmeric extract,
5 parts of water chestnut extract,
10 parts of bupleurum extract,
5 parts of tuckahoe extract,
3 parts of lithospermum extract,
0.8 part of wall-broken ganoderma lucidum spore powder,
3 parts of spirulina powder,
1.5 parts of raspberry polyphenol extract,
And 3 parts of starch grafted acrylate.
Further, the composition also comprises the following components in parts by weight:
47 parts of starch and 3 parts of magnesium stearate.
Further, the composition is an oral solid preparation in the forms of soft capsules, tablets, pills, powder and granules.
According to a second aspect of the present invention, there is provided a method for preparing the improved liver and kidney protecting, immunity regulating and constitution improving composition as described above, comprising the steps of:
(1) sieving and weighing
Respectively sieving radix astragali extract, fructus Ligustri Lucidi extract, Curcuma rhizome extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, radix Arnebiae extract, wall-broken Ganoderma spore powder and starch grafted acrylate with 100 mesh sieve, and weighing according to specified weight parts;
weighing spirulina powder and raspberry polyphenol extract according to the specified weight parts for later use;
sieving starch and magnesium stearate with a 80-mesh sieve respectively, and weighing the starch and the magnesium stearate in corresponding parts by weight for later use;
(2) mixing of
Mixing radix astragali extract, fructus Ligustri Lucidi extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, wall-broken Ganoderma spore powder, starch and magnesium stearate in a three-dimensional motion mixer for 30-60min to obtain a mixed powder I;
mixing spirulina powder, raspberry polyphenol extract, starch grafted acrylate, turmeric extract and lithospermum extract in a three-dimensional motion mixer in proportion for 30-60min until the color is uniform to obtain mixed powder II;
(3) preparation of
Transferring the mixed powder into a stirring kettle, adding a proper amount of pure water for mixing, stirring and uniformly mixing under a heating condition, and introducing into a pill making machine for primary pill preparation;
transferring the mixed powder II into a stirring kettle, adding a proper amount of pure water for mixing, and stirring and uniformly mixing under a heating condition to prepare a mixed solution;
wrapping the mixed solution outside the primary pills in a spraying mode, and naturally cooling;
repeating the spraying step for multiple times to obtain the improved composition for protecting liver and kidney, regulating immunity and improving physique;
(4) and (4) removing bubbles from the mixed solution in the step (3) in vacuum.
Further, in the step (3), the first mixed powder and the pure water are mixed and stirred at the rotating speed of 200rpm, and the heating temperature is 35-40 ℃.
Further, in the step (3), the mixing and stirring speed of the second mixed powder and pure water is 150rpm, and the heating temperature is 30-40 ℃.
Wherein, in the step (3), the spraying step is repeated for 3 to 6 times.
The invention has the following advantages:
the composition and the preparation thereof can provide health care functions for people with liver and kidney deficiency, low immunity and weak constitution for a long time aiming at the functional requirements of protecting liver and kidney, regulating immunity and improving constitution, so as to enhance the constitution of the people and improve the quality of life, wherein:
the medicinal astragalus root is the root of the astragalus root which is a perennial herb, has mild nature and sweet taste, enters spleen and lung channels, and has the effects of tonifying qi and raising yang, tonifying defensive qi and consolidating exterior, expelling toxin and promoting granulation, and inducing diuresis and removing edema. Radix astragali has wide application, and can be used for treating spleen-lung qi deficiency or qi depression; spontaneous sweating due to exterior deficiency caused by deficiency of defensive qi; non-ulceration or non-healing ulceration due to deficiency of qi and blood, edema, oliguria, numbness of limbs due to qi deficiency and blood stagnation, arthralgia, diabetes due to deficiency of qi and fluid, etc. A great deal of research on chemical components, pharmacological effects and clinical application of astragalus membranaceus has been carried out for many years, and particularly, the new pharmacological effects of astragalus membranaceus become a research focus in recent years. The pharmacological action is as follows: improving immunity, enhancing antioxidant, antiradiation and anticancer effects, protecting cardiovascular and cerebrovascular, liver, kidney and lung, protecting brain cells, improving memory, dilating vascular smooth muscle, inhibiting bacteria and virus, reducing blood lipid, lowering blood sugar, and reducing diabetic complications; clinically, astragalus membranaceus is widely used for treating diseases of a circulatory system, a nervous system, a digestive system, a respiratory system, endocrine and a blood system.
Fructus Ligustri Lucidi is dry mature fruit of Ligustrum lucidum ait of Oleaceae. It is cool in nature, sweet and bitter in taste, and enters liver and kidney meridians. Has effects in strengthening body resistance, consolidating constitution, nourishing liver and kidney, improving eyesight, and blackening hair. The book listed in Shen nong Ben Cao Jing is the top grade, which is called 'bitter and neutral taste, tonifying middle-jiao, calming five internal organs, nourishing spirit and removing all diseases'. Li Shizhen is said to "fruit is capable of strengthening yin, strengthening waist and knee, whitening hair and improving eyesight". The traditional Chinese medicine composition is mainly used for strengthening waist and knees, strengthening bones and muscles, blackening beard and hair, and treating yin deficiency and internal heat, dizziness, tinnitus and the like in clinic. In recent years, it has been used for treating chronic tracheitis, hepatitis, hyperlipidemia, diabetes, climacteric syndrome, infertility, atherosclerosis, etc. The application of glossy privet fruit to treat diseases has been in China for more than 2000 years.
Curcuma rhizome is dried rhizome of Curcuma rhizome of Zingiberaceae, and has warm nature, pungent and bitter taste, and spleen and liver meridian entered function. Has effects in removing blood stasis, promoting qi circulation, dredging channels, and relieving pain. Curcumin has a long research history and wide pharmacological action, and becomes a key point of domestic and overseas research in recent years. A large number of researches show that curcumin has various pharmacological effects such as antioxidation, anti-inflammation, anticancer, free radical scavenging, antimicrobial, cardiovascular system, digestive system and the like; it is used clinically in treating autoimmune diseases, rheumatic arthritis, inflammatory intestinal tract diseases, diabetes, tumor, chronic liver disease, senile dementia, etc. In addition, the medicine has low toxicity and convenient taking, so that the medicine has wider application value and development prospect.
The water chestnut fragrance is sweet, light, slightly bitter and pungent in flavor, fragrant, mild in nature and non-toxic. The efficacy is as follows: it can be orally administered for dispelling pathogenic wind, dispelling qi, relieving summer-heat, promoting urination, treating stranguria, and removing food stagnation. Enters the small intestine and bladder channel. It is indicated for abscess, deep-rooted boil and furuncle. The main treatment is as follows: urolithic stranguria, dysuria, hematuria, rheumatic edema, common cold, headache, wind cough, stomachache, and pain due to long-term retention.
Chaihu is a herb recorded in the Chinese pharmacopoeia, and the medicinal part is the dry root of Bupleurum chinense or Bupleurum scorzonerifolium of Umbelliferae. Collected in spring and autumn, removed stems and leaves and silt, and dried. Bupleurum root, radix bupleuri is a commonly used exterior syndrome relieving drug. Is also called as Diwu, potherb mustard, mushroom grass and firewood, is bitter in nature and taste, slightly cold, and enters liver and gallbladder meridians. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia.
Poria has sweet and light flavor and mild nature, and enters heart, lung, spleen and kidney meridians; is beneficial to the water and dampness permeability. Invigorating spleen and calming heart; can be used for treating edema, oliguria, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia; the main chemical components of the tuckahoe comprise pachyman and triterpenes, and modern pharmacological research shows that the tuckahoe has the effects of diuresis, anti-inflammation, bacteriostasis, liver protection, immunity enhancement and the like.
Lithospermum erythrorhizon is sweet and salty in flavor and enters heart and liver meridians; has the effects of stopping bleeding and cooling blood; can be used for treating diseases such as blood heat and toxic materials, macula purple black, measles without adequate eruption, fever macula, eczema, hematuria, bloody stranguria, bloody dysentery, constipation due to heat accumulation, pyocutaneous disease, erysipelas, burn, malignant boil, and tinea; the lithospermum contains various effective components such as naphthoquinones, monoterpene phenol, benzoquinones, phenolic acid and salts thereof, alkaloids, aliphatic compounds and ester compounds, and has various effects of bacteriostasis, inflammation resistance, cancer resistance, virus resistance, liver protection, oxidation resistance, tumor resistance, immunoregulation and the like.
The application also creatively adds the wall-broken ganoderma lucidum spore powder, the spirulina powder and the raspberry polyphenol extract which are proportioned, thereby improving the problem of drug effect reduction caused by easy oxidation in the original formula, establishing a component-wrapped structure type, further improving the technical effect of drug component oxidation resistance, and simultaneously ensuring that the drug effect can continuously play a role. The starch graft acrylate is added, so that the medicine has certain water retention capacity, and is favorable for quick decomposition and component absorption.
Detailed Description
The present invention is described in terms of particular embodiments, other advantages and features of the invention will become apparent to those skilled in the art from the following disclosure, and it is to be understood that the described embodiments are merely exemplary of the invention and that it is not intended to limit the invention to the particular embodiments disclosed. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
In order to solve related technical problems in the prior art, the embodiment of the application provides an improved composition for protecting the liver and the kidney, regulating immunity and improving physique, pills prepared by the composition and the preparation method are high in stability, the content and the stability of active ingredients are guaranteed to the maximum extent, the problem of easy oxidation failure is reduced, the requirements of people groups with liver and kidney deficiency, low immunity, weak constitution due to long-term diseases and the like on improving physique are met, and the effects of preventing various chronic diseases from occurring and developing, repairing damaged liver and kidney cells, improving immunity and improving life quality are achieved.
Based on the above description, the embodiments of the present application are obtained by scientific compatibility and improvement based on the original patent applications (application numbers: 201510771829.6 and 202110167543.2) of the applicant, and the use effect is greatly improved.
According to the first aspect of the invention, the invention provides an improved composition for protecting liver and kidney, regulating immunity and improving physique, which comprises the following components in parts by weight:
10-30 parts of astragalus extract,
5-20 parts of glossy privet fruit extract,
2-8 parts of turmeric extract,
2-5 parts of water chestnut extract,
8-15 parts of bupleurum extract,
3-6 parts of poria cocos extract,
2-6 parts of lithospermum extract,
0.5 to 1 portion of wall-broken ganoderma lucidum spore powder,
2-4 parts of spirulina powder,
1-2 parts of raspberry polyphenol extract,
2-4 parts of starch grafted acrylate.
Further, the improved composition for protecting liver and kidney, regulating immunity and improving physique comprises the following components in parts by weight:
20-25 parts of astragalus extract,
10-15 parts of glossy privet fruit extract,
4-6 parts of turmeric extract,
3-5 parts of water chestnut extract,
10-12 parts of bupleurum extract,
4-6 parts of poria cocos extract,
2-4 parts of lithospermum extract,
0.5 to 1 portion of wall-broken ganoderma lucidum spore powder,
2-3 parts of spirulina powder,
1.5-2 parts of raspberry polyphenol extract,
2.5-4 parts of starch grafted acrylate.
Further, the improved composition for protecting liver and kidney, regulating immunity and improving physique comprises the following components in parts by weight:
18 parts of astragalus extract,
12 parts of glossy privet fruit extract,
5 parts of turmeric extract,
5 parts of water chestnut extract,
10 parts of bupleurum extract,
5 parts of tuckahoe extract,
3 parts of lithospermum extract,
0.8 part of wall-broken ganoderma lucidum spore powder,
3 parts of spirulina powder,
1.5 parts of raspberry polyphenol extract,
And 3 parts of starch grafted acrylate.
Further, the composition also comprises the following components in parts by weight:
47 parts of starch and 3 parts of magnesium stearate.
Further, the composition is an oral solid preparation in the forms of soft capsules, tablets, pills, powder and granules.
According to a second aspect of the present invention, there is provided a method for preparing the improved liver and kidney protecting, immunity regulating and constitution improving composition as described above, comprising the steps of:
(1) sieving and weighing
Respectively sieving radix astragali extract, fructus Ligustri Lucidi extract, Curcuma rhizome extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, radix Arnebiae extract, wall-broken Ganoderma spore powder and starch grafted acrylate with 100 mesh sieve, and weighing according to specified weight parts;
weighing spirulina powder and raspberry polyphenol extract according to the specified weight parts for later use;
sieving starch and magnesium stearate with a 80-mesh sieve respectively, and weighing the starch and the magnesium stearate in corresponding parts by weight for later use;
(2) mixing
Mixing radix astragali extract, fructus Ligustri Lucidi extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, wall-broken Ganoderma spore powder, starch and magnesium stearate in a three-dimensional motion mixer for 30-60min to obtain a mixed powder I;
mixing spirulina powder, raspberry polyphenol extract, starch grafted acrylate, turmeric extract and lithospermum extract in a three-dimensional motion mixer in proportion for 30-60min until the color is uniform to obtain mixed powder II;
(3) preparation of
Transferring the mixed powder into a stirring kettle, adding a proper amount of pure water for mixing, stirring and uniformly mixing under a heating condition, and introducing into a pill making machine for primary pill preparation;
transferring the mixed powder II into a stirring kettle, adding a proper amount of pure water for mixing, and stirring and uniformly mixing under a heating condition to prepare a mixed solution;
wrapping the mixed solution outside the primary pills in a spraying mode, and naturally cooling;
repeating the spraying step for multiple times to obtain the improved composition for protecting liver and kidney, regulating immunity and improving physique;
(4) and (4) removing bubbles of the mixed solution in the step (3) in vacuum.
Further, in the step (3), the first mixed powder and the pure water are mixed and stirred at the rotating speed of 200rpm, and the heating temperature is 35-40 ℃.
Further, in the step (3), the mixing and stirring speed of the second mixed powder and pure water is 150rpm, and the heating temperature is 30-40 ℃.
Wherein, in the step (3), the spraying step is repeated for 3 to 6 times.
Based on the above description, the present application also provides the following embodiments:
example 1
The preparation of the improved composition for protecting liver and kidney, regulating immunity and improving physique includes the following steps:
(1) sieving and weighing
Respectively sieving radix astragali extract, fructus Ligustri Lucidi extract, Curcuma rhizome extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, radix Arnebiae extract, wall-broken Ganoderma spore powder and starch grafted acrylate with 100 mesh sieve, and weighing according to specified weight parts;
weighing the spirulina powder and the raspberry polyphenol extract according to the specified weight parts for later use;
sieving starch and magnesium stearate with a 80-mesh sieve respectively, and weighing the starch and the magnesium stearate in corresponding parts by weight for later use;
(2) mixing of
Mixing 12 parts of astragalus extract, 16 parts of glossy privet fruit extract, 3 parts of water chestnut extract, 12 parts of radix bupleuri extract, 5 parts of poria cocos extract, 1 part of wall-broken ganoderma spore powder, 47 parts of starch and 3 parts of magnesium stearate in a three-dimensional motion mixer in proportion for 30-60min until the color is uniform to obtain mixed powder I;
mixing 4 parts of spirulina powder, 1 part of raspberry polyphenol extract, 2 parts of starch grafted acrylate, 4 parts of turmeric extract and 2 parts of lithospermum extract in a three-dimensional motion mixer according to a proportion for 30-60min until the color is uniform, thereby obtaining mixed powder II;
(3) preparation of
Transferring the mixed powder into a stirring kettle, adding a proper amount of pure water, mixing, stirring and uniformly mixing under a heating condition, and introducing into a pill making machine for primary pill preparation;
transferring the mixed powder II into a stirring kettle, adding a proper amount of pure water for mixing, and stirring and uniformly mixing under a heating condition to prepare a mixed solution;
wrapping the mixed solution outside the primary pill by spraying, and naturally cooling;
repeating the spraying step for multiple times to obtain the improved composition for protecting liver and kidney, regulating immunity and improving physique;
(4) and (4) removing bubbles from the mixed solution in the step (3) in vacuum.
Further, in the step (3), the first mixed powder and the pure water are mixed and stirred at the rotating speed of 200rpm, and the heating temperature is 35-40 ℃.
Further, in the step (3), the mixing and stirring speed of the second mixed powder and pure water is 150rpm, and the heating temperature is 30-40 ℃.
Wherein, in the step (3), the spraying step is repeated for 3 to 6 times.
Example 2
The preparation of the improved composition for protecting liver and kidney, regulating immunity and improving physique includes the following steps:
(1) sieving and weighing
Respectively sieving radix astragali extract, fructus Ligustri Lucidi extract, Curcuma rhizome extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, radix Arnebiae extract, wall-broken Ganoderma spore powder and starch grafted acrylate with 100 mesh sieve, and weighing according to specified weight parts;
weighing the spirulina powder and the raspberry polyphenol extract according to the specified weight parts for later use;
sieving starch and magnesium stearate with a 80-mesh sieve respectively, and weighing the starch and the magnesium stearate in corresponding parts by weight for later use;
(2) mixing of
Mixing 15 parts of astragalus extract, 9 parts of glossy privet fruit extract, 2 parts of water chestnut extract, 10 parts of radix bupleuri extract, 4 parts of poria cocos extract, 0.5 part of wall-broken ganoderma spore powder, 47 parts of starch and 3 parts of magnesium stearate in a three-dimensional motion mixer according to a proportion for 30-60min until the color is uniform to obtain mixed powder I;
putting 2.5 parts of spirulina powder, 2 parts of raspberry polyphenol extract, 2.5 parts of starch grafted acrylate, 4 parts of turmeric extract and 4 parts of lithospermum extract into a three-dimensional motion mixer according to a proportion, and mixing for 30-60min until the color is uniform, thereby obtaining mixed powder II;
(3) preparation of
Transferring the mixed powder into a stirring kettle, adding a proper amount of pure water for mixing, stirring and uniformly mixing under a heating condition, and introducing into a pill making machine for primary pill preparation;
transferring the mixed powder II into a stirring kettle, adding a proper amount of pure water for mixing, and stirring and uniformly mixing under a heating condition to prepare a mixed solution;
wrapping the mixed solution outside the primary pills in a spraying mode, and naturally cooling;
repeating the spraying step for multiple times to obtain the improved composition for protecting liver and kidney, regulating immunity and improving physique;
(4) and (4) removing bubbles of the mixed solution in the step (3) in vacuum.
Further, in the step (3), the first mixed powder and the pure water are mixed and stirred at the rotating speed of 200rpm, and the heating temperature is 35-40 ℃.
Further, in the step (3), the mixing and stirring speed of the second mixed powder and pure water is 150rpm, and the heating temperature is 30-40 ℃.
Wherein, in the step (3), the spraying step is repeated for 3 to 6 times.
Example 3
The preparation of the improved composition for protecting liver and kidney, regulating immunity and improving physique includes the following steps:
(1) sieving and weighing
Respectively sieving radix astragali extract, fructus Ligustri Lucidi extract, Curcuma rhizome extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, radix Arnebiae extract, wall-broken Ganoderma spore powder and starch grafted acrylate with 100 mesh sieve, and weighing according to specified weight parts;
weighing spirulina powder and raspberry polyphenol extract according to the specified weight parts for later use;
sieving starch and magnesium stearate with a 80-mesh sieve respectively, and weighing the starch and the magnesium stearate in corresponding parts by weight for later use;
(2) mixing of
Mixing 21 parts of astragalus extract, 19 parts of glossy privet fruit extract, 5 parts of water chestnut extract, 11 parts of radix bupleuri extract, 3 parts of poria cocos extract, 0.8 part of wall-broken ganoderma spore powder, 47 parts of starch and 3 parts of magnesium stearate in a three-dimensional motion mixer according to a proportion for 30-60min until the color is uniform to obtain mixed powder I;
mixing 3.5 parts of spirulina powder, 1.3 parts of raspberry polyphenol extract, 4 parts of starch grafted acrylate, 3 parts of turmeric extract and 6 parts of lithospermum extract in a three-dimensional motion mixer according to a proportion for 30-60min until the color is uniform to obtain mixed powder II;
(3) preparation of
Transferring the mixed powder into a stirring kettle, adding a proper amount of pure water for mixing, stirring and uniformly mixing under a heating condition, and introducing into a pill making machine for primary pill preparation;
transferring the mixed powder II into a stirring kettle, adding a proper amount of pure water for mixing, and stirring and uniformly mixing under a heating condition to prepare a mixed solution;
wrapping the mixed solution outside the primary pills in a spraying mode, and naturally cooling;
repeating the spraying step for multiple times to obtain the improved composition for protecting liver and kidney, regulating immunity and improving physique;
(4) and (4) removing bubbles of the mixed solution in the step (3) in vacuum.
Further, in the step (3), the first mixed powder and the pure water are mixed and stirred at the rotating speed of 200rpm, and the heating temperature is 35-40 ℃.
Further, in the step (3), the mixing and stirring speed of the second mixed powder and pure water is 150rpm, and the heating temperature is 30-40 ℃.
Wherein, in the step (3), the spraying step is repeated for 3 to 6 times.
Example 4
The preparation of the improved composition for protecting liver and kidney, regulating immunity and improving physique comprises the following steps:
(1) sieving and weighing
Respectively sieving radix astragali extract, fructus Ligustri Lucidi extract, Curcuma rhizome extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, radix Arnebiae extract, wall-broken Ganoderma spore powder and starch grafted acrylate with 100 mesh sieve, and weighing according to specified weight parts;
weighing spirulina powder and raspberry polyphenol extract according to the specified weight parts for later use;
sieving starch and magnesium stearate with a 80-mesh sieve respectively, and weighing the starch and the magnesium stearate in corresponding parts by weight for later use;
(2) mixing
Mixing 27 parts of astragalus extract, 13 parts of glossy privet fruit extract, 4 parts of water chestnut extract, 14 parts of radix bupleuri extract, 6 parts of poria cocos extract, 1 part of wall-broken ganoderma spore powder, 47 parts of starch and 3 parts of magnesium stearate in a three-dimensional motion mixer in proportion for 30-60min until the color is uniform to obtain mixed powder I;
mixing 2 parts of spirulina powder, 1.8 parts of raspberry polyphenol extract, 3 parts of starch grafted acrylate, 8 parts of turmeric extract and 7 parts of lithospermum extract in a three-dimensional motion mixer according to a proportion for 30-60min until the color is uniform to obtain mixed powder II;
(3) preparation of
Transferring the mixed powder into a stirring kettle, adding a proper amount of pure water for mixing, stirring and uniformly mixing under a heating condition, and introducing into a pill making machine for primary pill preparation;
transferring the mixed powder II into a stirring kettle, adding a proper amount of pure water for mixing, and stirring and uniformly mixing under a heating condition to prepare a mixed solution;
wrapping the mixed solution outside the primary pill by spraying, and naturally cooling;
repeating the spraying step for multiple times to obtain the improved composition for protecting liver and kidney, regulating immunity and improving physique;
(4) and (4) removing bubbles from the mixed solution in the step (3) in vacuum.
Further, in the step (3), the first mixed powder and the pure water are mixed and stirred at the rotating speed of 200rpm, and the heating temperature is 35-40 ℃.
Further, in the step (3), the mixing and stirring speed of the second mixed powder and pure water is 150rpm, and the heating temperature is 30-40 ℃.
Wherein, in the step (3), the spraying step is repeated for 3 to 6 times.
Example 5
The preparation of the improved composition for protecting liver and kidney, regulating immunity and improving physique includes the following steps:
(1) sieving and weighing
Respectively sieving radix astragali extract, fructus Ligustri Lucidi extract, Curcuma rhizome extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, radix Arnebiae extract, wall-broken Ganoderma spore powder and starch grafted acrylate with 100 mesh sieve, and weighing according to specified weight parts;
weighing spirulina powder and raspberry polyphenol extract according to the specified weight parts for later use;
sieving starch and magnesium stearate with a 80-mesh sieve respectively, and weighing the starch and the magnesium stearate in corresponding parts by weight for later use;
(2) mixing
Mixing 18 parts of astragalus extract, 12 parts of glossy privet fruit extract, 5 parts of water chestnut extract, 10 parts of radix bupleuri extract, 5 parts of poria cocos extract, 0.8 part of wall-broken ganoderma spore powder, 47 parts of starch and 3 parts of magnesium stearate in a three-dimensional motion mixer according to a proportion for 30-60min until the color is uniform to obtain mixed powder I;
mixing 3 parts of spirulina powder, 1.5 parts of raspberry polyphenol extract, 3 parts of starch grafted acrylate, 5 parts of turmeric extract and 6 parts of lithospermum extract in a three-dimensional motion mixer according to a proportion for 30-60min until the color is uniform to obtain mixed powder II;
(3) preparation of
Transferring the mixed powder into a stirring kettle, adding a proper amount of pure water for mixing, stirring and uniformly mixing under a heating condition, and introducing into a pill making machine for primary pill preparation;
transferring the mixed powder II into a stirring kettle, adding a proper amount of pure water for mixing, and stirring and uniformly mixing under a heating condition to prepare a mixed solution;
wrapping the mixed solution outside the primary pill by spraying, and naturally cooling;
repeating the spraying step for multiple times to obtain the improved composition for protecting liver and kidney, regulating immunity and improving constitution;
(4) and (4) removing bubbles of the mixed solution in the step (3) in vacuum.
Further, in the step (3), the first mixed powder and the pure water are mixed and stirred at the rotating speed of 200rpm, and the heating temperature is 35-40 ℃.
Further, in the step (3), the mixing and stirring speed of the second mixed powder and pure water is 150rpm, and the heating temperature is 30-40 ℃.
Wherein, in the step (3), the spraying step is repeated for 3 to 6 times.
The composition and the preparation thereof can provide health care functions for people with liver and kidney deficiency, low immunity and weak constitution for a long time aiming at the functional requirements of protecting liver and kidney, regulating immunity and improving constitution, so as to enhance the constitution of the people and improve the quality of life, wherein:
the medicinal astragalus root is the root of the astragalus root which is a perennial herb, has mild nature and sweet taste, enters spleen and lung channels, and has the effects of tonifying qi and raising yang, tonifying defensive qi and consolidating exterior, expelling toxin and promoting granulation, and inducing diuresis and removing edema. Radix astragali has wide application, and can be used for treating spleen-lung qi deficiency or qi depression; spontaneous sweating due to exterior deficiency caused by deficiency of defensive qi; non-ulceration or non-healing ulceration due to deficiency of qi and blood, edema, oliguria, numbness of limbs due to qi deficiency and blood stagnation, arthralgia, diabetes due to deficiency of qi and fluid, etc. A great deal of research on chemical components, pharmacological effects and clinical application of astragalus membranaceus has been carried out for many years, and particularly, the new pharmacological effects of astragalus membranaceus become a research focus in recent years. The pharmacological action is as follows: improving immunity, enhancing antioxidant, antiradiation and anticancer effects, protecting cardiovascular and cerebrovascular, liver, kidney and lung, protecting brain cells, improving memory, dilating vascular smooth muscle, inhibiting bacteria and virus, reducing blood lipid, lowering blood sugar, and reducing diabetic complications; clinically, astragalus membranaceus is widely used for treating diseases of a circulatory system, a nervous system, a digestive system, a respiratory system, endocrine and a blood system.
Fructus Ligustri Lucidi is dry mature fruit of Ligustrum lucidum ait of Oleaceae. It is cool in nature, sweet and bitter in taste, and enters liver and kidney meridians. Has effects in strengthening body resistance, consolidating constitution, nourishing liver and kidney, improving eyesight, and blackening hair. The book listed in Shen nong Ben Cao Jing is the top grade, which is called 'bitter and neutral taste, tonifying middle-jiao, calming five internal organs, nourishing spirit and removing all diseases'. Li Shizhen is said to "fruit is capable of strengthening yin, strengthening waist and knee, whitening hair and improving eyesight". The traditional Chinese medicine composition is mainly used for strengthening waist and knees, strengthening bones and muscles, blackening beard and hair, and treating yin deficiency and internal heat, dizziness, tinnitus and the like in clinic. In recent years, it has been used for treating chronic tracheitis, hepatitis, hyperlipidemia, diabetes, climacteric syndrome, infertility, atherosclerosis, etc. The application of glossy privet fruit to treat diseases has been in China for more than 2000 years.
Curcuma rhizome is dried rhizome of Curcuma rhizome of Zingiberaceae, and has warm nature, pungent and bitter taste, and spleen and liver meridian entered. Has effects in removing blood stasis, promoting qi circulation, dredging channels, and relieving pain. Curcumin has a long research history and wide pharmacological action, and becomes a key point of domestic and overseas research in recent years. A large number of researches show that curcumin has various pharmacological effects such as antioxidation, anti-inflammation, anticancer, free radical scavenging, antimicrobial, cardiovascular system, digestive system and the like; it is used clinically in treating autoimmune diseases, rheumatic arthritis, inflammatory intestinal tract diseases, diabetes, tumor, chronic liver disease, senile dementia, etc. In addition, the medicine has low toxicity and convenient taking, so that the medicine has wider application value and development prospect.
The water chestnut fragrance is sweet, light, slightly bitter and pungent in flavor, fragrant, mild in nature and non-toxic. The efficacy is as follows: it can be orally administered for dispelling pathogenic wind, dispelling qi, relieving summer-heat, promoting urination, treating stranguria, and removing food stagnation. Enters the small intestine and bladder channel. It is indicated for abscess, deep-rooted boil and furuncle. The main indications are as follows: urolithic stranguria, dysuria, hematuria, rheumatic edema, common cold, headache, wind cough, stomachache, and pain due to long-term retention.
Chaihu is a herb recorded in the Chinese pharmacopoeia, and the medicinal part is the dry root of Bupleurum chinense or Bupleurum scorzonerifolium of Umbelliferae. Collected in spring and autumn, removed stems and leaves and silt, and dried. Bupleurum root, radix bupleuri is a commonly used exterior syndrome relieving drug. Is also called as Diwu, potherb mustard, mushroom grass and firewood, is bitter in nature and taste, slightly cold, and enters liver and gallbladder meridians. Has the functions of harmonizing exterior and interior, soothing liver and invigorating yang. Can be used for treating common cold, fever, malaria, stagnation of qi due to depression of the liver, distending pain of chest and hypochondrium, rectocele, uterine prolapse, and menoxenia.
Poria has sweet and light taste and neutral nature, and enters heart, lung, spleen and kidney meridians; is beneficial to the water and dampness permeability. Invigorating spleen and calming heart; can be used for treating edema, oliguria, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia; the main chemical components of the tuckahoe comprise pachyman and triterpenes, and modern pharmacological research shows that the tuckahoe has the effects of diuresis, anti-inflammation, bacteriostasis, liver protection, immunity enhancement and the like.
Radix Arnebiae is sweet and salty, and enters heart and liver meridians; has the effects of stopping bleeding and cooling blood; can be used for treating diseases such as blood heat and toxic materials, macula purple black, measles without adequate eruption, fever macula, eczema, hematuria, bloody stranguria, bloody dysentery, constipation due to heat accumulation, pyocutaneous disease, erysipelas, burn, malignant boil, and tinea; the lithospermum contains various effective components such as naphthoquinones, monoterpene phenol, benzoquinones, phenolic acid and salts thereof, alkaloids, aliphatic compounds and ester compounds, and has various effects of bacteriostasis, inflammation resistance, cancer resistance, virus resistance, liver protection, oxidation resistance, tumor resistance, immunoregulation and the like.
The application also creatively adds the wall-broken ganoderma lucidum spore powder, the spirulina powder and the raspberry polyphenol extract which are proportioned, thereby improving the problem of drug effect reduction caused by easy oxidation in the original formula, establishing a component-wrapped structure type, further improving the technical effect of drug component oxidation resistance, and simultaneously ensuring that the drug effect can continuously play a role. The starch graft acrylate is added, so that the medicine has certain water retention capacity, and is favorable for quick decomposition and component absorption. Experiments prove that after the composition is taken, the human body constitution is obviously improved, the effect taking speed is high, the immunity is enhanced, and the liver and kidney protecting effect is obvious.
The preparation method of the invention prepares acceptable formulations in health food category according to the optimized fine process: preferably oral solid preparation, specifically soft capsule, tablet, powder, granule, etc. The components are selected from high-quality raw materials, the purity and the activity are high, the safety is high, the raw materials are simple and easy to obtain, and the medicine is convenient to take and is a scientific formula for protecting liver and kidney, regulating immunity and improving physique. Has certain theoretical significance and practical value for the development of health care products for the middle-aged and the elderly and the young.
Although the invention has been described in detail above with reference to a general description and specific examples, it will be apparent to one skilled in the art that modifications or improvements may be made thereto based on the invention. Accordingly, such modifications and improvements are intended to be within the scope of the invention as claimed.
Claims (10)
1. An improved composition for protecting liver and kidney, regulating immunity and improving physique is characterized by comprising the following components in parts by weight:
10-30 parts of astragalus extract,
5-20 parts of glossy privet fruit extract,
2-8 parts of turmeric extract,
2-5 parts of water chestnut extract,
8-15 parts of bupleurum extract,
3-6 parts of poria cocos extract,
2-6 parts of lithospermum extract,
0.5 to 1 portion of wall-broken ganoderma lucidum spore powder,
2-4 parts of spirulina powder,
1-2 parts of raspberry polyphenol extract,
2-4 parts of starch grafted acrylate.
2. The improved composition for protecting liver and kidney, regulating immunity and improving physical fitness according to claim 1, comprising the following components in parts by weight:
20-25 parts of astragalus extract,
10-15 parts of glossy privet fruit extract,
4-6 parts of turmeric extract,
3-5 parts of water chestnut extract,
10-12 parts of bupleurum extract,
4-6 parts of poria cocos extract,
2-4 parts of lithospermum extract,
0.5 to 1 portion of wall-broken ganoderma lucidum spore powder,
2-3 parts of spirulina powder,
1.5-2 parts of raspberry polyphenol extract,
2.5-4 parts of starch grafted acrylate.
3. The improved composition for protecting liver and kidney, regulating immunity and improving physique as claimed in claim 1, which comprises the following components in parts by weight:
18 parts of astragalus extract,
12 parts of glossy privet fruit extract,
5 parts of turmeric extract,
5 parts of water chestnut extract,
10 parts of bupleurum extract,
5 parts of tuckahoe extract,
3 parts of lithospermum extract,
0.8 part of wall-broken ganoderma lucidum spore powder,
3 parts of spirulina powder,
1.5 parts of raspberry polyphenol extract,
And 3 parts of starch grafted acrylate.
4. The improved composition for protecting liver and kidney, regulating immunity and improving physical fitness according to any one of claims 1-3, further comprising the following components in parts by weight:
47 parts of starch and 3 parts of magnesium stearate.
5. The improved composition for protecting liver and kidney, regulating immunity and improving physique as claimed in claim 4, wherein the composition is one of soft capsule, tablet, pill, powder and granule for oral administration and solid preparation.
6. A method for preparing the composition for improving liver and kidney protection, immunity regulation and physique improvement according to any one of claims 1 to 4, comprising the steps of:
(1) sieving and weighing
Respectively sieving radix astragali extract, fructus Ligustri Lucidi extract, Curcuma rhizome extract, herba asari extract, bupleuri radix extract, Poria extract, radix Arnebiae extract, cell wall-broken Ganoderma spore powder and starch grafted acrylate with 100 mesh sieve, and weighing according to the specified weight parts;
weighing spirulina powder and raspberry polyphenol extract according to the specified weight parts for later use;
sieving starch and magnesium stearate with a 80-mesh sieve respectively, and weighing the starch and the magnesium stearate in corresponding parts by weight for later use;
(2) mixing of
Mixing radix astragali extract, fructus Ligustri Lucidi extract, herba asari Forbesii extract, bupleuri radix extract, Poria extract, wall-broken Ganoderma spore powder, starch and magnesium stearate in a three-dimensional motion mixer for 30-60min to obtain a mixed powder I;
mixing spirulina powder, raspberry polyphenol extract, starch grafted acrylate, turmeric extract and lithospermum extract in a three-dimensional motion mixer in proportion for 30-60min until the color is uniform to obtain mixed powder II;
(3) preparation of
Transferring the mixed powder into a stirring kettle, adding a proper amount of pure water, mixing, stirring and uniformly mixing under a heating condition, and introducing into a pill making machine for primary pill preparation;
transferring the mixed powder II into a stirring kettle, adding a proper amount of pure water for mixing, and stirring and uniformly mixing under a heating condition to prepare a mixed solution;
wrapping the mixed solution outside the primary pills in a spraying mode, and naturally cooling;
repeating the spraying steps for a plurality of times to obtain the improved composition for protecting liver and kidney, regulating immunity and improving physique.
7. The method according to claim 6, wherein in the step (3), the first mixed powder is mixed with pure water at a stirring speed of 200rpm and the heating temperature is 35 to 40 ℃.
8. The method according to claim 6, wherein in the step (3), the second mixed powder is mixed with pure water at a stirring speed of 150rpm and a heating temperature of 30 to 40 ℃.
9. The method according to claim 6, wherein in the step (3), the spraying step is repeated 3 to 6 times.
10. The method of claim 6, further comprising the steps of:
(4) and (4) removing bubbles of the mixed solution in the step (3) in vacuum.
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| CN105288476A (en) * | 2015-11-13 | 2016-02-03 | 北京元莱健康管理有限公司 | Composition capable of protecting liver and kidney, adjusting immunity and improving constitution, and preparation method thereof |
| CN112755155A (en) * | 2021-02-07 | 2021-05-07 | 元莱健康产品(武汉)有限公司 | Composition for protecting liver and kidney, regulating immunity and improving physique and preparation method thereof |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105288476A (en) * | 2015-11-13 | 2016-02-03 | 北京元莱健康管理有限公司 | Composition capable of protecting liver and kidney, adjusting immunity and improving constitution, and preparation method thereof |
| CN112755155A (en) * | 2021-02-07 | 2021-05-07 | 元莱健康产品(武汉)有限公司 | Composition for protecting liver and kidney, regulating immunity and improving physique and preparation method thereof |
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