CN114728914A - 二氧代哌嗪类衍生物、其制备方法及其在医药上的应用 - Google Patents
二氧代哌嗪类衍生物、其制备方法及其在医药上的应用 Download PDFInfo
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- CN114728914A CN114728914A CN202080079337.XA CN202080079337A CN114728914A CN 114728914 A CN114728914 A CN 114728914A CN 202080079337 A CN202080079337 A CN 202080079337A CN 114728914 A CN114728914 A CN 114728914A
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- dioxopiperazin
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/02—Antithrombotic agents; Anticoagulants; Platelet aggregation inhibitors
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- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D241/00—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings
- C07D241/02—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings
- C07D241/04—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having no double bonds between ring members or between ring members and non-ring members
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- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Medicinal Chemistry (AREA)
- Animal Behavior & Ethology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Bioinformatics & Cheminformatics (AREA)
- General Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Diabetes (AREA)
- Hematology (AREA)
- Epidemiology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
Abstract
提供二氧代哌嗪类衍生物、其制备方法及其在医药上的应用。具体而言，提供式(I)的化合物或其立体异构体、互变异构体、药学上可接受的盐。这些化合物是选择性因子XIa(Factor XIa，简称FXIa)的抑制剂。还涉及包含这些化合物的药物组合物以及使用该化合物治疗血栓栓塞等疾病的药物中的用途。
Description
PCT国内申请，说明书已公开。
Claims (14)
- PCT国内申请，权利要求书已公开。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN2019111479493 | 2019-11-21 | ||
| CN201911147949 | 2019-11-21 | ||
| PCT/CN2020/130361 WO2021098817A1 (zh) | 2019-11-21 | 2020-11-20 | 二氧代哌嗪类衍生物、其制备方法及其在医药上的应用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114728914A true CN114728914A (zh) | 2022-07-08 |
| CN114728914B CN114728914B (zh) | 2023-05-12 |
Family
ID=75979946
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202080079337.XA Active CN114728914B (zh) | 2019-11-21 | 2020-11-20 | 二氧代哌嗪类衍生物、其制备方法及其在医药上的应用 |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN114728914B (zh) |
| TW (1) | TWI749881B (zh) |
| WO (1) | WO2021098817A1 (zh) |
Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101039A (zh) * | 1993-05-14 | 1995-04-05 | 第一制药株式会社 | 哌嗪衍生物 |
| CN101218227A (zh) * | 2005-07-08 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 作为因子Xa的抑制剂的杂环磺酰胺衍生物 |
| CN102026996A (zh) * | 2008-03-13 | 2011-04-20 | 百时美施贵宝公司 | 作为凝血因子xia抑制剂的哒嗪衍生物 |
| WO2014009872A1 (en) * | 2012-07-09 | 2014-01-16 | Lupin Limited | Tetrahydroquinazolinone derivatives as parp inhibitors |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6464176B2 (ja) * | 2014-01-31 | 2019-02-06 | ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ | 芳香族ｐ２’基を有する第ｘｉａ因子阻害剤としてのマクロ環 |
| CN107793396B (zh) * | 2016-08-31 | 2021-02-26 | 江苏恒瑞医药股份有限公司 | 环氧基取代的氧代吡啶类衍生物、其制备方法及其在医药上的应用 |
| WO2018041122A1 (zh) * | 2016-08-31 | 2018-03-08 | 江苏恒瑞医药股份有限公司 | 氧代吡啶酰胺类衍生物、其制备方法及其在医药上的应用 |
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2020
- 2020-11-19 TW TW109140529A patent/TWI749881B/zh active
- 2020-11-20 CN CN202080079337.XA patent/CN114728914B/zh active Active
- 2020-11-20 WO PCT/CN2020/130361 patent/WO2021098817A1/zh active Application Filing
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN1101039A (zh) * | 1993-05-14 | 1995-04-05 | 第一制药株式会社 | 哌嗪衍生物 |
| CN101218227A (zh) * | 2005-07-08 | 2008-07-09 | 阿斯利康(瑞典)有限公司 | 作为因子Xa的抑制剂的杂环磺酰胺衍生物 |
| CN102026996A (zh) * | 2008-03-13 | 2011-04-20 | 百时美施贵宝公司 | 作为凝血因子xia抑制剂的哒嗪衍生物 |
| WO2014009872A1 (en) * | 2012-07-09 | 2014-01-16 | Lupin Limited | Tetrahydroquinazolinone derivatives as parp inhibitors |
Also Published As
| Publication number | Publication date |
|---|---|
| WO2021098817A1 (zh) | 2021-05-27 |
| TW202120499A (zh) | 2021-06-01 |
| TWI749881B (zh) | 2021-12-11 |
| CN114728914B (zh) | 2023-05-12 |
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