CN114728101B - 重构脂质体安那霉素的方法 - Google Patents

重构脂质体安那霉素的方法 Download PDF

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Publication number
CN114728101B
CN114728101B CN202080048890.7A CN202080048890A CN114728101B CN 114728101 B CN114728101 B CN 114728101B CN 202080048890 A CN202080048890 A CN 202080048890A CN 114728101 B CN114728101 B CN 114728101B
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Prior art keywords
anamycin
liposomal
saline
bag
vial
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Chinese (zh)
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CN114728101A (zh
Inventor
D·皮克
W·普里布
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Molekulin Biotechnology
University of Texas System
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Molekulin Biotechnology
University of Texas System
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Priority to CN202310738252.3A priority Critical patent/CN116785242A/zh
Publication of CN114728101A publication Critical patent/CN114728101A/zh
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/0012—Galenical forms characterised by the site of application
    • A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/26—Carbohydrates, e.g. sugar alcohols, amino sugars, nucleic acids, mono-, di- or oligo-saccharides; Derivatives thereof, e.g. polysorbates, sorbitan fatty acid esters or glycyrrhizin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K9/00—Medicinal preparations characterised by special physical form
    • A61K9/10—Dispersions; Emulsions
    • A61K9/127—Synthetic bilayered vehicles, e.g. liposomes or liposomes with cholesterol as the only non-phosphatidyl surfactant
    • A61K9/1277—Preparation processes; Proliposomes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/02—Antineoplastic agents specific for leukemia

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  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Dispersion Chemistry (AREA)
  • Molecular Biology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Dermatology (AREA)
  • Oncology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Hematology (AREA)
  • Engineering & Computer Science (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Biochemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicinal Preparation (AREA)
  • Saccharide Compounds (AREA)
CN202080048890.7A 2019-06-28 2020-06-25 重构脂质体安那霉素的方法 Active CN114728101B (zh)

Priority Applications (1)

Application Number Priority Date Filing Date Title
CN202310738252.3A CN116785242A (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法以及应用

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US201962868190P 2019-06-28 2019-06-28
US62/868,190 2019-06-28
PCT/US2020/039621 WO2020264161A1 (en) 2019-06-28 2020-06-25 Method of reconstituting liposomal annamycin

Related Child Applications (1)

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CN202310738252.3A Division CN116785242A (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法以及应用

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Publication Number Publication Date
CN114728101A CN114728101A (zh) 2022-07-08
CN114728101B true CN114728101B (zh) 2023-07-14

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CN202080048890.7A Active CN114728101B (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法
CN202310738252.3A Pending CN116785242A (zh) 2019-06-28 2020-06-25 重构脂质体安那霉素的方法以及应用

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US (2) US12257262B2 (https=)
EP (1) EP3990041B1 (https=)
JP (1) JP7830131B2 (https=)
KR (1) KR20220027941A (https=)
CN (2) CN114728101B (https=)
AU (2) AU2020302784A1 (https=)
BR (1) BR112021026480A2 (https=)
CA (1) CA3144443A1 (https=)
ES (1) ES3049663T3 (https=)
IL (1) IL289433B1 (https=)
MX (1) MX2021015667A (https=)
PL (1) PL3990041T3 (https=)
SG (1) SG11202113005SA (https=)
TW (2) TWI857086B (https=)
WO (1) WO2020264161A1 (https=)

Families Citing this family (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
MX2021015668A (es) 2019-06-28 2022-04-18 Univ Texas Preparacion de un liofilizado de anamicina preliposomica.
BR112021026480A2 (pt) 2019-06-28 2022-02-08 Univ Texas Método para reconstituir anamicina, método para preparar uma dose eficaz de uma formulação lipossômica reconstituída de anamicina e método para tratar câncer
EP4061810A4 (en) * 2019-11-21 2023-12-20 Board of Regents, The University of Texas System Lung targeted anticancer therapies with liposomal annamycin

Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393530A (en) * 1990-12-11 1995-02-28 Bracco International B.V. Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated
WO2019023873A1 (zh) * 2017-07-31 2019-02-07 江苏竞诺择生物医药科技有限公司 一种用于治疗造血系统增殖性疾病的纳米脂质微粒组合物及药用组合物

Family Cites Families (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4927571A (en) * 1987-05-18 1990-05-22 Liposome Technology, Inc. Preparation of injectable doxorubicin/liposome suspension
US4863739A (en) 1987-05-19 1989-09-05 Board Of Regents, The University Of Texas System Liposome compositions of anthracycline derivatives
US5902604A (en) * 1995-06-06 1999-05-11 Board Of Regents, The University Of Texas System Submicron liposome suspensions obtained from preliposome lyophilizates
WO2001032145A1 (en) 1999-10-29 2001-05-10 Board Of Regents, The University Of Texas System Method of cancer treatment
TWI433693B (zh) * 2003-02-14 2014-04-11 Childrens Hosp & Res Ct Oak 親脂藥物傳送媒介物及其使用方法
ES2637072T3 (es) * 2010-03-10 2017-10-10 Cempra Pharmaceuticals, Inc. Formulación parenteral de antibióticos macrólidos
IL301603A (en) * 2011-10-14 2023-05-01 Genentech Inc Pertuzumab, trastuzumab, docetaxel and carboplatin for use in the preoperative treatment of a patient
SI2768484T1 (sl) * 2011-10-21 2019-12-31 Jazz Pharmaceuticals Research Llc Liofilizirani liposomi
US8926994B2 (en) 2011-12-07 2015-01-06 The Methodist Hospital Research Institute Mesoporous silicon particles for the presentation of tumor antigens and adjuvant for anti-cancer immunity
KR20170060042A (ko) 2014-09-13 2017-05-31 노파르티스 아게 Alk 억제제의 조합 요법
KR20170066546A (ko) 2014-10-03 2017-06-14 노파르티스 아게 조합 요법
CN107569508A (zh) * 2016-07-05 2018-01-12 江苏竞诺择生物医药科技有限公司 一种治疗造血系统增殖性疾病的药用组合物
KR20190067172A (ko) 2016-09-09 2019-06-14 아이리시스, 인크. 리포좀 항암 조성물
CN112955145A (zh) 2018-09-04 2021-06-11 密涅瓦神经科学有限公司 使用苯氧丙胺化合物治疗疼痛的方法
BR112021026480A2 (pt) 2019-06-28 2022-02-08 Univ Texas Método para reconstituir anamicina, método para preparar uma dose eficaz de uma formulação lipossômica reconstituída de anamicina e método para tratar câncer
MX2021015668A (es) 2019-06-28 2022-04-18 Univ Texas Preparacion de un liofilizado de anamicina preliposomica.
EP4061810A4 (en) 2019-11-21 2023-12-20 Board of Regents, The University of Texas System Lung targeted anticancer therapies with liposomal annamycin

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5393530A (en) * 1990-12-11 1995-02-28 Bracco International B.V. Method for making liposomes of enhanced entrapping capacity toward foreign substances to be encapsulated
WO2019023873A1 (zh) * 2017-07-31 2019-02-07 江苏竞诺择生物医药科技有限公司 一种用于治疗造血系统增殖性疾病的纳米脂质微粒组合物及药用组合物

Also Published As

Publication number Publication date
KR20220027941A (ko) 2022-03-08
AU2024203593A1 (en) 2024-07-11
ES3049663T3 (en) 2025-12-17
AU2024203593B2 (en) 2025-08-14
EP3990041B1 (en) 2025-08-06
IL289433B1 (en) 2026-01-01
US11980634B2 (en) 2024-05-14
US20220105116A1 (en) 2022-04-07
CN114728101A (zh) 2022-07-08
TWI857086B (zh) 2024-10-01
SG11202113005SA (en) 2021-12-30
EP3990041A4 (en) 2023-07-12
WO2020264161A1 (en) 2020-12-30
TW202114704A (zh) 2021-04-16
TW202500161A (zh) 2025-01-01
MX2021015667A (es) 2022-04-18
US20240024345A1 (en) 2024-01-25
CA3144443A1 (en) 2020-12-30
PL3990041T3 (pl) 2026-02-23
CN116785242A (zh) 2023-09-22
JP2023523872A (ja) 2023-06-08
JP7830131B2 (ja) 2026-03-16
US12257262B2 (en) 2025-03-25
IL289433A (en) 2022-02-01
EP3990041A1 (en) 2022-05-04
BR112021026480A2 (pt) 2022-02-08
AU2020302784A1 (en) 2022-01-20

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