CN114727992A - 作为Kv1.3钾Shaker通道阻滞剂的芳基亚甲基芳族化合物 - Google Patents

作为Kv1.3钾Shaker通道阻滞剂的芳基亚甲基芳族化合物 Download PDF

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CN114727992A
CN114727992A CN202080084417.4A CN202080084417A CN114727992A CN 114727992 A CN114727992 A CN 114727992A CN 202080084417 A CN202080084417 A CN 202080084417A CN 114727992 A CN114727992 A CN 114727992A
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F·焦尔达内托
M·O·詹森
V·乔吉尼
R·J·斯诺
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DE Shaw Research LLC
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    • C07D213/04—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D213/60—Heterocyclic compounds containing six-membered rings, not condensed with other rings, with one nitrogen atom as the only ring hetero atom and three or more double bonds between ring members or between ring members and non-ring members having three double bonds between ring members or between ring members and non-ring members having no bond between the ring nitrogen atom and a non-ring member or having only hydrogen or carbon atoms directly attached to the ring nitrogen atom with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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MX2023003841A (es) 2020-10-06 2023-06-23 De Shaw Res Llc Compuestos lactámicos como bloqueadores del canal agitador de potasio kv1.3.
US20240116962A1 (en) * 2020-12-31 2024-04-11 Tsinghua University Pyridine-2-amine derivative and pharmaceutical composition and use thereof
AU2022239717A1 (en) 2021-03-15 2023-11-02 Maze Therapeutics, Inc. Inhibitors of glycogen synthase 1 (gys1) and methods of use thereof
CN115703734B (zh) * 2021-08-05 2024-08-09 重庆文理学院 二芳基甲基吡啶类化合物及其制备方法和应用
TW202345806A (zh) 2022-03-31 2023-12-01 美商艾伯維有限公司 噻唑并〔５，４－ｂ〕吡啶ｍａｌｔ－１抑制劑
CN120202194A (zh) 2022-11-16 2025-06-24 巴斯夫欧洲公司 作为杀真菌剂的取代的四氢苯并二氮杂䓬
WO2024104815A1 (en) 2022-11-16 2024-05-23 Basf Se Substituted benzodiazepines as fungicides
KR20250156732A (ko) 2023-03-17 2025-11-03 바스프 에스이 식물병원성 진균을 퇴치하기 위한 치환된 피리딜/피라지딜 디히드로벤조티아제핀 화합물
TW202521512A (zh) 2023-07-31 2025-06-01 美商美國禮來大藥廠 Kv1.3鉀shaker通道阻斷劑之固體形式及其使用方法
WO2026057374A1 (en) 2024-09-11 2026-03-19 Basf Se Fungicidal mixture comprising substituted pyridyl/pyrazidyl dihydrobenzothiazepine compounds

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080039442A1 (en) * 2004-12-21 2008-02-14 Devgen Nv Compounds With Kv4 Ion Channel Activity
CN101888989A (zh) * 2007-10-04 2010-11-17 生态学有限公司 新型芳基钾通道阻断剂及其应用
CN107949559A (zh) * 2015-08-27 2018-04-20 辉瑞公司 作为irak4调节剂的双环稠合杂芳基或芳基化合物

Family Cites Families (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CH540009A (de) * 1970-07-23 1973-09-28 Ciba Geigy Ag Verwendung von Monohydroxyphenylcarbinolen zum antimikrobiellen Ausrüsten bzw. zum Schützen von textilen Materialien gegen schädliche Mikroorganismen
JPH07309837A (ja) * 1993-04-28 1995-11-28 Takeda Chem Ind Ltd ピリジン誘導体、その製造法および剤
JPH09278757A (ja) * 1996-04-15 1997-10-28 Takeda Chem Ind Ltd ヒドラゾン誘導体および剤
TW467902B (en) 1996-07-31 2001-12-11 Bristol Myers Squibb Co Diphenyl heterocycles as potassium channel modulators
JP2002501912A (ja) 1998-01-29 2002-01-22 ブリストル−マイヤーズ スクイブ カンパニー ジアリール１、３、４−オキサジアゾロンのベンゾエート誘導体
GB0815784D0 (en) 2008-08-29 2008-10-08 Xention Ltd Novel potassium channel blockers
GB0909672D0 (en) 2009-06-04 2009-07-22 Xention Discovery Ltd Compounds
RU2595894C2 (ru) * 2010-08-27 2016-08-27 Грюненталь Гмбх Замещенные 2-окси-хинолин-3-карбоксамиды в качестве модуляторов kcnq2/3
AU2014244257B2 (en) * 2013-03-13 2017-12-14 Kristina M. PANNONE Triazine compounds and compositions thereof and methods for treating malaria and chemoprophylaxis
EP3490542A4 (en) * 2016-07-26 2020-07-08 Flagship Pioneering Innovations V, Inc. NEUROMODULATION COMPOSITIONS AND RELATED THERAPEUTIC METHODS FOR THE TREATMENT OF CANCER BY MODULATION OF AN ANTI-CANCER RESPONSE

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20080039442A1 (en) * 2004-12-21 2008-02-14 Devgen Nv Compounds With Kv4 Ion Channel Activity
CN101888989A (zh) * 2007-10-04 2010-11-17 生态学有限公司 新型芳基钾通道阻断剂及其应用
CN107949559A (zh) * 2015-08-27 2018-04-20 辉瑞公司 作为irak4调节剂的双环稠合杂芳基或芳基化合物

Non-Patent Citations (2)

* Cited by examiner, † Cited by third party
Title
"Columbus, Ohio, US REGISTR[Online]", 《REGISTR》, 23 October 2014 (2014-10-23), pages 1146963 - 24 *
COLUMBUS, OHIO, US: "REGISTR[Online]", 《REGISTR》, 3 September 2014 (2014-09-03), pages 936253 - 74 *

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