CN114727911A - 用于局部施用的两相组合物 - Google Patents
用于局部施用的两相组合物 Download PDFInfo
- Publication number
- CN114727911A CN114727911A CN201980102565.1A CN201980102565A CN114727911A CN 114727911 A CN114727911 A CN 114727911A CN 201980102565 A CN201980102565 A CN 201980102565A CN 114727911 A CN114727911 A CN 114727911A
- Authority
- CN
- China
- Prior art keywords
- taurate
- phase
- weight
- phase composition
- methyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000000203 mixture Substances 0.000 title claims abstract description 121
- 230000000699 topical effect Effects 0.000 title claims abstract description 11
- 239000012071 phase Substances 0.000 claims abstract description 118
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 claims abstract description 47
- 229940104261 taurate Drugs 0.000 claims abstract description 44
- XOAAWQZATWQOTB-UHFFFAOYSA-N taurine Chemical compound NCCS(O)(=O)=O XOAAWQZATWQOTB-UHFFFAOYSA-N 0.000 claims abstract description 44
- 239000008346 aqueous phase Substances 0.000 claims abstract description 39
- -1 fatty acid esters Chemical class 0.000 claims abstract description 38
- 239000004094 surface-active agent Substances 0.000 claims abstract description 20
- 239000004215 Carbon black (E152) Substances 0.000 claims abstract description 19
- 229930195733 hydrocarbon Natural products 0.000 claims abstract description 18
- 150000002430 hydrocarbons Chemical class 0.000 claims abstract description 18
- 239000002562 thickening agent Substances 0.000 claims abstract description 18
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 17
- 239000000194 fatty acid Substances 0.000 claims abstract description 17
- 229930195729 fatty acid Natural products 0.000 claims abstract description 17
- 239000002736 nonionic surfactant Substances 0.000 claims abstract description 17
- 102000011782 Keratins Human genes 0.000 claims abstract description 15
- 108010076876 Keratins Proteins 0.000 claims abstract description 15
- 239000000463 material Substances 0.000 claims abstract description 15
- 239000000839 emulsion Substances 0.000 claims abstract description 12
- 238000000034 method Methods 0.000 claims abstract description 12
- 239000007764 o/w emulsion Substances 0.000 claims abstract description 5
- 239000003921 oil Substances 0.000 claims description 34
- QGZKDVFQNNGYKY-UHFFFAOYSA-O Ammonium Chemical compound [NH4+] QGZKDVFQNNGYKY-UHFFFAOYSA-O 0.000 claims description 21
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 claims description 18
- 239000011591 potassium Substances 0.000 claims description 18
- 229910052700 potassium Inorganic materials 0.000 claims description 18
- 239000003795 chemical substances by application Substances 0.000 claims description 16
- 235000011187 glycerol Nutrition 0.000 claims description 15
- 150000001298 alcohols Chemical class 0.000 claims description 10
- 239000002537 cosmetic Substances 0.000 claims description 10
- 239000002253 acid Substances 0.000 claims description 9
- 229920001577 copolymer Polymers 0.000 claims description 9
- 229920000084 Gum arabic Polymers 0.000 claims description 8
- 235000010489 acacia gum Nutrition 0.000 claims description 8
- 239000000205 acacia gum Substances 0.000 claims description 8
- 229940071088 methyl cocoyl taurate Drugs 0.000 claims description 8
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 8
- 125000002811 oleoyl group Chemical group O=C([*])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])/C([H])=C([H])\C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])C([H])([H])[H] 0.000 claims description 8
- 150000007513 acids Chemical class 0.000 claims description 7
- 125000000217 alkyl group Chemical group 0.000 claims description 7
- 150000005691 triesters Chemical class 0.000 claims description 6
- 150000005690 diesters Chemical class 0.000 claims description 5
- 239000003974 emollient agent Substances 0.000 claims description 5
- 229940048109 sodium methyl cocoyl taurate Drugs 0.000 claims description 5
- 230000000475 sunscreen effect Effects 0.000 claims description 5
- 239000000516 sunscreening agent Substances 0.000 claims description 5
- 229920001285 xanthan gum Polymers 0.000 claims description 5
- 235000010493 xanthan gum Nutrition 0.000 claims description 5
- 239000000230 xanthan gum Substances 0.000 claims description 5
- 229940082509 xanthan gum Drugs 0.000 claims description 5
- 229920000536 2-Acrylamido-2-methylpropane sulfonic acid Polymers 0.000 claims description 4
- XHZPRMZZQOIPDS-UHFFFAOYSA-N 2-Methyl-2-[(1-oxo-2-propenyl)amino]-1-propanesulfonic acid Chemical group OS(=O)(=O)CC(C)(C)NC(=O)C=C XHZPRMZZQOIPDS-UHFFFAOYSA-N 0.000 claims description 4
- 244000215068 Acacia senegal Species 0.000 claims description 4
- ROSDSFDQCJNGOL-UHFFFAOYSA-N Dimethylamine Chemical compound CNC ROSDSFDQCJNGOL-UHFFFAOYSA-N 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 229920002907 Guar gum Polymers 0.000 claims description 4
- 229920000161 Locust bean gum Polymers 0.000 claims description 4
- 239000004909 Moisturizer Substances 0.000 claims description 4
- 229940061720 alpha hydroxy acid Drugs 0.000 claims description 4
- 150000001280 alpha hydroxy acids Chemical class 0.000 claims description 4
- 230000003712 anti-aging effect Effects 0.000 claims description 4
- 229940121363 anti-inflammatory agent Drugs 0.000 claims description 4
- 239000002260 anti-inflammatory agent Substances 0.000 claims description 4
- 230000000845 anti-microbial effect Effects 0.000 claims description 4
- 239000003963 antioxidant agent Substances 0.000 claims description 4
- 239000007844 bleaching agent Substances 0.000 claims description 4
- 229940106189 ceramide Drugs 0.000 claims description 4
- 150000001783 ceramides Chemical class 0.000 claims description 4
- 239000007854 depigmenting agent Substances 0.000 claims description 4
- 229930003935 flavonoid Natural products 0.000 claims description 4
- 150000002215 flavonoids Chemical class 0.000 claims description 4
- 235000017173 flavonoids Nutrition 0.000 claims description 4
- 235000010417 guar gum Nutrition 0.000 claims description 4
- 239000000665 guar gum Substances 0.000 claims description 4
- 229960002154 guar gum Drugs 0.000 claims description 4
- 229920001519 homopolymer Polymers 0.000 claims description 4
- 235000010420 locust bean gum Nutrition 0.000 claims description 4
- 239000000711 locust bean gum Substances 0.000 claims description 4
- 230000001333 moisturizer Effects 0.000 claims description 4
- 125000006353 oxyethylene group Chemical group 0.000 claims description 4
- 238000012216 screening Methods 0.000 claims description 4
- CAVXVRQDZKMZDB-UHFFFAOYSA-M sodium;2-[dodecanoyl(methyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCC(=O)N(C)CCS([O-])(=O)=O CAVXVRQDZKMZDB-UHFFFAOYSA-M 0.000 claims description 4
- HJXBXTZDPSSEST-UHFFFAOYSA-M sodium;2-[methyl(tetradecanoyl)amino]ethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCCC(=O)N(C)CCS([O-])(=O)=O HJXBXTZDPSSEST-UHFFFAOYSA-M 0.000 claims description 4
- IZWPGJFSBABFGL-GMFCBQQYSA-M sodium;2-[methyl-[(z)-octadec-9-enoyl]amino]ethanesulfonate Chemical compound [Na+].CCCCCCCC\C=C/CCCCCCCC(=O)N(C)CCS([O-])(=O)=O IZWPGJFSBABFGL-GMFCBQQYSA-M 0.000 claims description 4
- 235000013343 vitamin Nutrition 0.000 claims description 4
- 239000011782 vitamin Substances 0.000 claims description 4
- 229940088594 vitamin Drugs 0.000 claims description 4
- 229930003231 vitamin Natural products 0.000 claims description 4
- 239000000341 volatile oil Substances 0.000 claims description 4
- 230000002087 whitening effect Effects 0.000 claims description 4
- JNAYPSWVMNJOPQ-UHFFFAOYSA-N 2,3-bis(16-methylheptadecanoyloxy)propyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCC(OC(=O)CCCCCCCCCCCCCCC(C)C)COC(=O)CCCCCCCCCCCCCCC(C)C JNAYPSWVMNJOPQ-UHFFFAOYSA-N 0.000 claims description 3
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 claims description 3
- 239000013543 active substance Substances 0.000 claims description 3
- 229920001222 biopolymer Polymers 0.000 claims description 3
- 230000002051 biphasic effect Effects 0.000 claims description 3
- 150000004676 glycans Chemical class 0.000 claims description 3
- 229920001282 polysaccharide Polymers 0.000 claims description 3
- 239000005017 polysaccharide Substances 0.000 claims description 3
- 239000011734 sodium Substances 0.000 claims description 3
- 229910052708 sodium Inorganic materials 0.000 claims description 3
- 229940071160 cocoate Drugs 0.000 claims description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 33
- 235000019198 oils Nutrition 0.000 description 30
- VYPSYNLAJGMNEJ-UHFFFAOYSA-N Silicium dioxide Chemical compound O=[Si]=O VYPSYNLAJGMNEJ-UHFFFAOYSA-N 0.000 description 13
- 125000004432 carbon atom Chemical group C* 0.000 description 12
- 238000009472 formulation Methods 0.000 description 9
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 description 8
- DNIAPMSPPWPWGF-UHFFFAOYSA-N Propylene glycol Chemical compound CC(O)CO DNIAPMSPPWPWGF-UHFFFAOYSA-N 0.000 description 8
- 150000005215 alkyl ethers Chemical class 0.000 description 8
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical class OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 7
- 235000019197 fats Nutrition 0.000 description 7
- OSCJHTSDLYVCQC-UHFFFAOYSA-N 2-ethylhexyl 4-[[4-[4-(tert-butylcarbamoyl)anilino]-6-[4-(2-ethylhexoxycarbonyl)anilino]-1,3,5-triazin-2-yl]amino]benzoate Chemical compound C1=CC(C(=O)OCC(CC)CCCC)=CC=C1NC1=NC(NC=2C=CC(=CC=2)C(=O)NC(C)(C)C)=NC(NC=2C=CC(=CC=2)C(=O)OCC(CC)CCCC)=N1 OSCJHTSDLYVCQC-UHFFFAOYSA-N 0.000 description 6
- MTHSVFCYNBDYFN-UHFFFAOYSA-N diethylene glycol Chemical compound OCCOCCO MTHSVFCYNBDYFN-UHFFFAOYSA-N 0.000 description 6
- 150000002148 esters Chemical class 0.000 description 6
- 229920002125 Sokalan® Polymers 0.000 description 5
- 230000000052 comparative effect Effects 0.000 description 5
- 238000005191 phase separation Methods 0.000 description 5
- JNYAEWCLZODPBN-JGWLITMVSA-N (2r,3r,4s)-2-[(1r)-1,2-dihydroxyethyl]oxolane-3,4-diol Chemical compound OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O JNYAEWCLZODPBN-JGWLITMVSA-N 0.000 description 4
- BANXPJUEBPWEOT-UHFFFAOYSA-N 2-methyl-Pentadecane Chemical compound CCCCCCCCCCCCCC(C)C BANXPJUEBPWEOT-UHFFFAOYSA-N 0.000 description 4
- KFZMGEQAYNKOFK-UHFFFAOYSA-N Isopropanol Chemical compound CC(C)O KFZMGEQAYNKOFK-UHFFFAOYSA-N 0.000 description 4
- 150000004665 fatty acids Chemical class 0.000 description 4
- 239000004615 ingredient Substances 0.000 description 4
- PSQFOYNNWBCJMY-UHFFFAOYSA-N 2-[2-(2-hydroxyethoxy)ethoxy]ethyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCCOCCOCCO PSQFOYNNWBCJMY-UHFFFAOYSA-N 0.000 description 3
- QZCLKYGREBVARF-UHFFFAOYSA-N Acetyl tributyl citrate Chemical compound CCCCOC(=O)CC(C(=O)OCCCC)(OC(C)=O)CC(=O)OCCCC QZCLKYGREBVARF-UHFFFAOYSA-N 0.000 description 3
- HRPVXLWXLXDGHG-UHFFFAOYSA-N Acrylamide Chemical compound NC(=O)C=C HRPVXLWXLXDGHG-UHFFFAOYSA-N 0.000 description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 3
- XEKOWRVHYACXOJ-UHFFFAOYSA-N Ethyl acetate Chemical compound CCOC(C)=O XEKOWRVHYACXOJ-UHFFFAOYSA-N 0.000 description 3
- SGVYKUFIHHTIFL-UHFFFAOYSA-N Isobutylhexyl Natural products CCCCCCCC(C)C SGVYKUFIHHTIFL-UHFFFAOYSA-N 0.000 description 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- SZXQTJUDPRGNJN-UHFFFAOYSA-N dipropylene glycol Chemical compound OCCCOCCCO SZXQTJUDPRGNJN-UHFFFAOYSA-N 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- GLDOVTGHNKAZLK-UHFFFAOYSA-N octadecan-1-ol Chemical compound CCCCCCCCCCCCCCCCCCO GLDOVTGHNKAZLK-UHFFFAOYSA-N 0.000 description 3
- 229920005862 polyol Polymers 0.000 description 3
- 239000003755 preservative agent Substances 0.000 description 3
- 150000003626 triacylglycerols Chemical class 0.000 description 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 description 2
- WNWHHMBRJJOGFJ-UHFFFAOYSA-N 16-methylheptadecan-1-ol Chemical compound CC(C)CCCCCCCCCCCCCCCO WNWHHMBRJJOGFJ-UHFFFAOYSA-N 0.000 description 2
- 229940043268 2,2,4,4,6,8,8-heptamethylnonane Drugs 0.000 description 2
- SMZOUWXMTYCWNB-UHFFFAOYSA-N 2-(2-methoxy-5-methylphenyl)ethanamine Chemical compound COC1=CC=C(C)C=C1CCN SMZOUWXMTYCWNB-UHFFFAOYSA-N 0.000 description 2
- ALVGIJJKUWXGCF-UHFFFAOYSA-N 2-[2-[2-(16-methylheptadecanoyloxy)ethoxy]ethoxy]ethyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCCOCCOCCOC(=O)CCCCCCCCCCCCCCC(C)C ALVGIJJKUWXGCF-UHFFFAOYSA-N 0.000 description 2
- XMVBHZBLHNOQON-UHFFFAOYSA-N 2-butyl-1-octanol Chemical compound CCCCCCC(CO)CCCC XMVBHZBLHNOQON-UHFFFAOYSA-N 0.000 description 2
- SVTBMSDMJJWYQN-UHFFFAOYSA-N 2-methylpentane-2,4-diol Chemical compound CC(O)CC(C)(C)O SVTBMSDMJJWYQN-UHFFFAOYSA-N 0.000 description 2
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 description 2
- PTHBKNSHSCMKBV-UHFFFAOYSA-N 4,6,8-trihydroxy-3-(2-hydroxyethyl)-2,3-dihydronaphtho[2,3-f][1]benzofuran-5,10-dione Chemical compound O=C1C2=CC(O)=CC(O)=C2C(=O)C2=C1C=C1OCC(CCO)C1=C2O PTHBKNSHSCMKBV-UHFFFAOYSA-N 0.000 description 2
- HBTAOSGHCXUEKI-UHFFFAOYSA-N 4-chloro-n,n-dimethyl-3-nitrobenzenesulfonamide Chemical compound CN(C)S(=O)(=O)C1=CC=C(Cl)C([N+]([O-])=O)=C1 HBTAOSGHCXUEKI-UHFFFAOYSA-N 0.000 description 2
- NIXOWILDQLNWCW-UHFFFAOYSA-N Acrylic acid Chemical compound OC(=O)C=C NIXOWILDQLNWCW-UHFFFAOYSA-N 0.000 description 2
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 description 2
- 229920001213 Polysorbate 20 Polymers 0.000 description 2
- 239000004372 Polyvinyl alcohol Substances 0.000 description 2
- UIIMBOGNXHQVGW-UHFFFAOYSA-M Sodium bicarbonate Chemical compound [Na+].OC([O-])=O UIIMBOGNXHQVGW-UHFFFAOYSA-M 0.000 description 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 description 2
- 240000007313 Tilia cordata Species 0.000 description 2
- ZFOZVQLOBQUTQQ-UHFFFAOYSA-N Tributyl citrate Chemical compound CCCCOC(=O)CC(O)(C(=O)OCCCC)CC(=O)OCCCC ZFOZVQLOBQUTQQ-UHFFFAOYSA-N 0.000 description 2
- 235000018936 Vitellaria paradoxa Nutrition 0.000 description 2
- 241001135917 Vitellaria paradoxa Species 0.000 description 2
- 239000011149 active material Substances 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 239000002671 adjuvant Substances 0.000 description 2
- 125000002947 alkylene group Chemical group 0.000 description 2
- 239000008168 almond oil Substances 0.000 description 2
- DKPFZGUDAPQIHT-UHFFFAOYSA-N butyl acetate Chemical compound CCCCOC(C)=O DKPFZGUDAPQIHT-UHFFFAOYSA-N 0.000 description 2
- 229910052799 carbon Inorganic materials 0.000 description 2
- 229940073669 ceteareth 20 Drugs 0.000 description 2
- 229940031578 diisopropyl adipate Drugs 0.000 description 2
- LYCAIKOWRPUZTN-UHFFFAOYSA-N ethylene glycol Natural products OCCO LYCAIKOWRPUZTN-UHFFFAOYSA-N 0.000 description 2
- 150000002191 fatty alcohols Chemical class 0.000 description 2
- 210000003128 head Anatomy 0.000 description 2
- MNWFXJYAOYHMED-UHFFFAOYSA-N heptanoic acid group Chemical group C(CCCCCC)(=O)O MNWFXJYAOYHMED-UHFFFAOYSA-N 0.000 description 2
- 229910052500 inorganic mineral Inorganic materials 0.000 description 2
- KUVMKLCGXIYSNH-UHFFFAOYSA-N isopentadecane Natural products CCCCCCCCCCCCC(C)C KUVMKLCGXIYSNH-UHFFFAOYSA-N 0.000 description 2
- 229940115478 isopropyl lauroyl sarcosinate Drugs 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 238000004519 manufacturing process Methods 0.000 description 2
- 239000011707 mineral Substances 0.000 description 2
- 235000010755 mineral Nutrition 0.000 description 2
- 229960005323 phenoxyethanol Drugs 0.000 description 2
- 229920002401 polyacrylamide Polymers 0.000 description 2
- 229920000642 polymer Polymers 0.000 description 2
- 229920000193 polymethacrylate Polymers 0.000 description 2
- 150000003077 polyols Chemical class 0.000 description 2
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 description 2
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 description 2
- 229940068977 polysorbate 20 Drugs 0.000 description 2
- 229920002451 polyvinyl alcohol Polymers 0.000 description 2
- 230000002335 preservative effect Effects 0.000 description 2
- XLCIFRJORZNGEV-UHFFFAOYSA-N propan-2-yl 2-[dodecanoyl(methyl)amino]acetate Chemical compound CCCCCCCCCCCC(=O)N(C)CC(=O)OC(C)C XLCIFRJORZNGEV-UHFFFAOYSA-N 0.000 description 2
- 229940057910 shea butter Drugs 0.000 description 2
- 239000000377 silicon dioxide Substances 0.000 description 2
- 159000000000 sodium salts Chemical class 0.000 description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N squalane Chemical compound CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 description 2
- 150000005846 sugar alcohols Polymers 0.000 description 2
- 238000012360 testing method Methods 0.000 description 2
- BGHCVCJVXZWKCC-UHFFFAOYSA-N tetradecane Chemical compound CCCCCCCCCCCCCC BGHCVCJVXZWKCC-UHFFFAOYSA-N 0.000 description 2
- IIYFAKIEWZDVMP-UHFFFAOYSA-N tridecane Chemical compound CCCCCCCCCCCCC IIYFAKIEWZDVMP-UHFFFAOYSA-N 0.000 description 2
- PTHBKNSHSCMKBV-ZETCQYMHSA-N versicol Natural products OCC[C@H]1COc2cc3C(=O)c4cc(O)cc(O)c4C(=O)c3c(O)c12 PTHBKNSHSCMKBV-ZETCQYMHSA-N 0.000 description 2
- ALSTYHKOOCGGFT-KTKRTIGZSA-N (9Z)-octadecen-1-ol Chemical compound CCCCCCCC\C=C/CCCCCCCCO ALSTYHKOOCGGFT-KTKRTIGZSA-N 0.000 description 1
- 229940043375 1,5-pentanediol Drugs 0.000 description 1
- VBICKXHEKHSIBG-UHFFFAOYSA-N 1-monostearoylglycerol Chemical compound CCCCCCCCCCCCCCCCCC(=O)OCC(O)CO VBICKXHEKHSIBG-UHFFFAOYSA-N 0.000 description 1
- OVYMWJFNQQOJBU-UHFFFAOYSA-N 1-octanoyloxypropan-2-yl octanoate Chemical compound CCCCCCCC(=O)OCC(C)OC(=O)CCCCCCC OVYMWJFNQQOJBU-UHFFFAOYSA-N 0.000 description 1
- XDOFQFKRPWOURC-UHFFFAOYSA-N 16-methylheptadecanoic acid Chemical compound CC(C)CCCCCCCCCCCCCCC(O)=O XDOFQFKRPWOURC-UHFFFAOYSA-N 0.000 description 1
- ABEXEQSGABRUHS-UHFFFAOYSA-N 16-methylheptadecyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)CCCCCCCCCCCCCCC(C)C ABEXEQSGABRUHS-UHFFFAOYSA-N 0.000 description 1
- RWKSBJVOQGKDFZ-UHFFFAOYSA-N 16-methylheptadecyl 2-hydroxypropanoate Chemical compound CC(C)CCCCCCCCCCCCCCCOC(=O)C(C)O RWKSBJVOQGKDFZ-UHFFFAOYSA-N 0.000 description 1
- FLPJVCMIKUWSDR-UHFFFAOYSA-N 2-(4-formylphenoxy)acetamide Chemical compound NC(=O)COC1=CC=C(C=O)C=C1 FLPJVCMIKUWSDR-UHFFFAOYSA-N 0.000 description 1
- FEBUJFMRSBAMES-UHFFFAOYSA-N 2-[(2-{[3,5-dihydroxy-2-(hydroxymethyl)-6-phosphanyloxan-4-yl]oxy}-3,5-dihydroxy-6-({[3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy}methyl)oxan-4-yl)oxy]-3,5-dihydroxy-6-(hydroxymethyl)oxan-4-yl phosphinite Chemical compound OC1C(O)C(O)C(CO)OC1OCC1C(O)C(OC2C(C(OP)C(O)C(CO)O2)O)C(O)C(OC2C(C(CO)OC(P)C2O)O)O1 FEBUJFMRSBAMES-UHFFFAOYSA-N 0.000 description 1
- DJXPNUIRGNRCPQ-UHFFFAOYSA-N 2-[2,3-bis[2-(16-methylheptadecanoyloxy)ethoxy]propoxy]ethyl 16-methylheptadecanoate Chemical compound CC(C)CCCCCCCCCCCCCCC(=O)OCCOCC(COCCOC(=O)CCCCCCCCCCCCCCC(C)C)OCCOC(=O)CCCCCCCCCCCCCCC(C)C DJXPNUIRGNRCPQ-UHFFFAOYSA-N 0.000 description 1
- LCZVSXRMYJUNFX-UHFFFAOYSA-N 2-[2-(2-hydroxypropoxy)propoxy]propan-1-ol Chemical compound CC(O)COC(C)COC(C)CO LCZVSXRMYJUNFX-UHFFFAOYSA-N 0.000 description 1
- DWHIUNMOTRUVPG-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-(2-dodecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCO DWHIUNMOTRUVPG-UHFFFAOYSA-N 0.000 description 1
- JKXYOQDLERSFPT-UHFFFAOYSA-N 2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-[2-(2-octadecoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethanol Chemical compound CCCCCCCCCCCCCCCCCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCO JKXYOQDLERSFPT-UHFFFAOYSA-N 0.000 description 1
- SFAAOBGYWOUHLU-UHFFFAOYSA-N 2-ethylhexyl hexadecanoate Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(CC)CCCC SFAAOBGYWOUHLU-UHFFFAOYSA-N 0.000 description 1
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Abstract
一种用于局部施用的两相组合物,其包含:a)含有至少一种牛磺酸盐表面活性剂和至少一种亲水性增稠剂的水相;和b)含有至少一种烃油和选自甘油的氧化烯化脂肪酸酯的至少一种非离子表面活性剂的脂肪相,其中水相和脂肪相是分开的。本发明还涉及用于护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部的方法,其包括摇晃如上所述的两相组合物以形成水包油乳液并将该乳液施用于角蛋白材料。
Description
技术领域
本发明涉及用于护理和/或化妆角蛋白材料的化妆品组合物。特别地,本发明涉及用于局部施用的两相组合物。本发明还涉及用于护理和/或化妆角蛋白材料的方法。
背景
由两个分开的相、尤其是分开的水相和脂肪相组成的组合物通常被称为“两相组合物”。两相组合物因其珍珠状的外观而对消费者有吸引力。两个相静止时被单一界面分开。
两相组合物已描述于例如文献EP 0 370 856和EP 0 603 080中,尤其是用于卸除眼妆。
文献EP 0 603 080描述了使用烷基二甲基苄基铵且尤其是苯扎氯铵作为相分离剂以获得快速相分离。
文献EP 1 514 534还描述了含有碳酸氢钠作为相分离剂的两相组合物。
WO 2014/207259A2公开了包含乙酸镁的用于局部施用的两相组合物。
使用两相组合物需要事先摇晃以便形成乳液。上文提及的所有两相组合物的特征都在于其使用后两个相快速相分离(或分层)。也就是说,上文提及的两相组合物易于通过摇晃乳化,并且在停止摇晃后经历快速相分离。
具体而言,对于上文提及的两相组合物而言获得快速的相分离是合意的,尤其是因为两个相的不佳分离会使使用者认为是无美感的。
然而,通过摇晃获得的乳液必须具有充足的稳定性以使得两个相能够均匀施用。
因此,仍需要由两个分开的相组成的两相组合物,其在摇晃后将形成稳定且均匀的乳液。
发明概述
因此,本(发明)的一个目的是提供用于护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部的两相组合物,其在摇晃后将形成稳定且均匀的珍珠状乳液。
本发明的另一个目的是提供用于护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部的方法。
因此,根据第一方面,本发明提供用于局部施用的两相组合物,其包含:
a)含有至少一种牛磺酸盐表面活性剂和至少一种亲水性增稠剂的水相;和
b)含有至少一种烃油和选自甘油的氧化烯化脂肪酸酯的至少一种非离子表面活性剂的脂肪相,
其中水相和脂肪相是分开的。
根据第二方面,本发明提供用于护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部的方法,其包括摇晃如上所述的两相组合物以形成水包油乳液并将该乳液施用于角蛋白材料。
令人惊讶地,发明人已经发现,利用包含在水相中的至少一种牛磺酸盐表面活性剂和至少一种亲水性增稠剂以及在脂肪相中的至少一种烃油和选自甘油的氧化烯化脂肪酸酯的至少一种非离子表面活性剂的根据本发明的两相组合物,可以获得具有所需品质的两相组合物,即,其在摇晃后将形成稳定且均匀的闪亮的珍珠状乳液。
不意图受限于任何理论,据信牛磺酸盐表面活性剂、选自甘油的氧化烯化脂肪酸酯的非离子表面活性剂和亲水性增稠剂的组合将使在摇晃后形成的油滴在水相中稳定。
另外,根据本发明的两相组合物使得消费者能够自己体验转换过程。
本发明的其它优点将在阅读以下说明书和实施例时更清楚地显现。
发明详述
根据本发明的第一方面,用于局部施用的两相组合物包含:
a)含有至少一种牛磺酸盐表面活性剂和至少一种亲水性增稠剂的水相;和
b)含有至少一种烃油和选自甘油的氧化烯化脂肪酸酯的至少一种非离子表面活性剂的脂肪相,
其中水相和脂肪相是分开的。
“水相和脂肪相是分开的”表示在摇晃前可见水相和脂肪相一者在另一者上。
在摇晃形成稳定且均匀的水包油乳液后,该两相组合物可用来护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部。
“皮肤”表示所有身体皮肤,包括脸部、嘴唇和眼部。
术语“稳定”表示在组合物制造后至少一个月、且尤其是其制造后至少两个月,组合物不经历其结构或性质上的任何明显变化。
除非另外指出,否则如本文中所使用的值范围的限值被包括在该范围内,特别是在表述“介于…和…之间”和“从…至…”中。
如本文中所使用的术语“包含/包括(comprising)”应被解释为涵盖所有明确提及的特征以及任选的、另外的未指定的特征。
如本文中所使用的,术语“包含/包括”的使用还公开了不存在除明确提及的特征以外的特征(即,“由…组成”)的实施方案。
除非另外定义,否则本文中使用的所有技术和科学术语都具有与本发明所属领域的技术人员所通常理解的相同的含义。当本说明书中的术语的定义与本发明所属领域的技术人员所通常理解的含义冲突时,本文中描述的定义应当适用。
除非另外指定,否则说明书和权利要求书中使用的表示成分等等的量的所有数值都应被理解为被术语“约”修饰。因此,除非有相反的指示,否则本文中描述的数值和参数是能够根据如要求获得的所需性能变化的近似值。
如本文中所使用的,本说明书中使用的表述“至少一种/至少一个(at leastone)”等同于表述“一种或更多种/一个或更多个(one or more)”。
本文中使用的术语“和/或”指代所提及要素中的一者或全部。
水相
根据本发明的第一方面,两相组合物包含水相。
水相包含水。
所用水可为无菌脱矿质水和/或花水,诸如玫瑰水、矢车菊水、洋甘菊水或菩提花水(lime blossom water),和/或天然泉水或矿泉水,例如:伟图(Vittel)水、维希盆地(Vichy basin)水、依泉(Uriage)水、Roche Posay水、Bourboule水、昂吉安莱班(Enghien-les-Bains)水、圣热尔韦莱班(Saint Gervais-les-Bains)水、内里莱班(Néris-les-Bains)水、Allevar-les-Bains水、迪涅(Digne)水、Maizières水、Neyrac-les-Bains水、隆勒索涅(Lons-le-Saunier)水、Eaux Bonnes水、罗什福尔(Rochefort)水、Saint Christau水、Fumades水、Tercis-les-bains水和雅漾(Avene)水。水相还可包含复原泉水,即,复原了泉水的特性,含有诸如锌、铜、镁等微量元素的水。
水相还可包含水混溶性有机溶剂(在室温25℃下),例如:含有2至6个碳原子的一元醇,诸如乙醇或异丙醇;包含至少两个游离羟基,尤其是含有2至20个碳原子、优选含有2至10个碳原子且优选含有2至6个碳原子的多元醇,诸如甘油、丙二醇、丁二醇、戊二醇、己二醇、一缩二丙二醇或一缩二乙二醇;二醇醚(尤其含有3至16个碳原子),诸如单丙二醇(C1-C4)烷基醚、一缩二丙二醇(C1-C4)烷基醚或二缩三丙二醇(C1-C4)烷基醚、单乙二醇(C1-C4)烷基醚、一缩二乙二醇(C1-C4)烷基醚或二缩三乙二醇(C1-C4)烷基醚,及其混合物。
本发明的组合物的水相优选包含水和醇,该醇选自:一元醇,例如乙醇或异丙醇;以及多元醇,例如优选丁二醇、一缩二丙二醇、甘油、或丙二醇、PEG-8。
有利地,水相以相对于两相组合物的总重量计在50重量%至99重量%、优选55重量%至98重量%、甚至更优选60重量%至97重量%范围内的量存在。
如本文中所使用的,水相的量包括水相中溶解或分散的所有成分的量。
牛磺酸盐表面活性剂
根据本发明的第一方面,两相组合物的水相含有至少一种牛磺酸盐表面活性剂。
例如,可用于本发明的牛磺酸盐表面活性剂包括式(I)的那些:
其中,
R1为(C8-C22)烷基;
R2为H或(C1-C4)烷基;
R3和R4各自独立地为H或(C1-C4)烷基;并且
M+为钠、钾或铵阳离子。
例如,牛磺酸盐表面活性剂可选自:甲基月桂酰基牛磺酸钠、甲基肉豆蔻酰基牛磺酸钠、甲基椰油酰基牛磺酸钠、甲基油酰基牛磺酸钠、甲基月桂酰基牛磺酸钾、甲基肉豆蔻酰基牛磺酸钾、甲基椰油酰基牛磺酸钾、甲基油酰基牛磺酸钾、甲基月桂酰基牛磺酸铵、甲基肉豆蔻酰基牛磺酸铵、甲基椰油酰基牛磺酸铵和甲基油酰基牛磺酸铵。
在优选实施方案中,牛磺酸盐表面活性剂为甲基椰油酰基牛磺酸钠。
有利地,牛磺酸盐表面活性剂以相对于两相组合物的总重量计0.1重量%至1重量%、优选0.2重量%至1重量%、更优选0.3重量%至1重量%的量存在。
亲水性增稠剂
根据本发明的第一方面,两相组合物的水相含有至少一种亲水性增稠剂。
术语“亲水性增稠剂”旨在表示能够提高组合物的水相的粘度的化合物。
亲水性增稠剂可单独使用或组合使用。
作为亲水性增稠剂,可特别提及水溶性或水分散性增稠聚合物。它们可特别选自:
-聚乙烯吡咯烷酮,
-聚乙烯醇,
-改性或未改性的羧乙烯基聚合物,诸如由Goodrich公司以名称Carbopol® (CTFA名称:卡波姆)出售的产品;
-丙烯酸或甲基丙烯酸或其盐及其酯的均聚物或共聚物,且特别是由AlliedColloid公司以名称Versicol F®或Versicol K®或Salcare SC95,由Ciba-Geigy公司以名称Ultrahold 8®出售的产品;聚丙烯酸酯和聚甲基丙烯酸酯,诸如由Guardian公司以名称Lubrajel和Norgel或者由Hispano Chimica公司以名称Hispagel出售的产品,Synthalen K型的聚丙烯酸;
-聚丙烯酰胺;
-丙烯酸和丙烯酰胺的共聚物,由Hercules公司以名称Reten®以其钠盐形式出售;聚甲基丙烯酸钠,由Vanderbilt公司以名称Darvan N°7®出售;多羟基羧酸的钠盐,由Henkel公司以名称Hydagen F®出售;
- 2-丙烯酰胺基-2-甲基丙磺酸的均聚物和共聚物,其任选地经交联和/或中和,例如由Clariant公司以名称Hostacerin AMPS®出售的聚(2-丙烯酰胺基-2-甲基丙磺酸)(CTFA名称:聚丙烯酰基二甲基牛磺酸铵);
-交联的阴离子丙烯酰胺/AMPS共聚物,呈W/O乳液的形式,诸如由SEPPIC公司以名称Sepigel 305 (CTFA名称:聚丙烯酰胺/C13-14异链烷烃/月桂醇聚醚-7)和以名称Simulgel 600 (CTFA名称:丙烯酰胺/丙烯酰基二甲基牛磺酸钠共聚物/异十六烷/聚山梨醇酯80)出售的那些;
- Pemulen型的聚丙烯酸/丙烯酸烷基酯共聚物;
-多糖生物聚合物,例如黄原胶、瓜尔胶、阿拉伯树胶、刺槐豆胶、金合欢胶、硬葡聚糖、甲壳素衍生物和壳聚糖衍生物、角叉菜胶、结冷胶、藻酸盐,或纤维素,诸如微晶纤维素、羧甲基纤维素、羟甲基纤维素、羟乙基纤维素和羟丙基纤维素。可提及例如由CP Kelco公司以商品名Keltrol® CG-T出售的黄原胶;
-亲水性煅制二氧化硅,其通过在氢氧焰中高温水解挥发性硅化合物从而产生细碎的二氧化硅来获得。亲水性二氧化硅在其表面具有大量的硅烷醇基团。此类亲水性二氧化硅例如由Degussa公司以名称Aerosil 130®、Aerosil 200®、Aerosil 255®、Aerosil 300®和Aerosil 380®,或由Cabot公司以名称Cab-O-Sil HS-5®、Cab-O-Sil EH-5®、Cab-O-SilLM-130®、Cab-O-Sil MS-55®和Cab-O-Sil M-5®出售。它们优选具有可为纳米级至微米级、例如在约5 nm至200 nm范围内的粒度;
-亲水性粘土;
-缔合聚合物,例如由Rohm & Haas以名称Aculyn 46出售的PEG-150/硬脂醇/SMDI共聚物,或由Elementis以名称Rheolate FX 1100出售的硬脂醇聚醚-100/PEG-136/HDI共聚物;
-及其混合物。
根据优选的实施方案,亲脂性增稠剂选自2-丙烯酰胺基-2-甲基丙磺酸的均聚物和共聚物,以及多糖生物聚合物。
根据更优选的实施方案,亲脂性增稠剂选自聚丙烯酰基二甲基牛磺酸铵、黄原胶、瓜尔胶、阿拉伯树胶、刺槐豆胶、金合欢胶。
优选地,亲脂性增稠剂以相对于两相组合物的总重量计0.1重量%至2重量%、优选0.2重量%至1.5重量%、更优选0.3重量%至1重量%的量存在。
脂肪相
根据本发明的第一方面,两相组合物包含脂肪相。
有利地,脂肪相以相对于两相组合物的总重量计在1重量%至50重量%、优选2重量%至45重量%、甚至更优选3重量%至40重量%范围内的量存在。
基于烃的油
根据本发明的第一方面,两相组合物的脂肪相含有至少一种烃油。
术语“油”表示在室温(25℃)和大气压(760 mmHg)下为液体的与水不混溶的非水化合物。
术语“基于烃的油”表示基本上由碳原子和氢原子以及任选的氧原子和氮原子形成,或甚至由碳原子和氢原子以及任选的氧原子和氮原子组成,且不含任何硅原子或氟原子的油。其可含有醇、酯、醚、羧酸、胺和/或酰胺基团。
基于烃的油可选自:
-含有8至16个碳原子的基于烃的油,且尤其是:
-支链C8-C16烷烃,例如石油来源的C8-C16异烷烃(也被称为异链烷烃),例如异十二烷(也称为2,2,4,4,6-五甲基庚烷)、异癸烷、异十六烷,和例如以商品名Isopar或Permethyl出售的油,
-直链烷烃,例如正十二烷(C12)和正十四烷(C14),由Sasol以相应参考名Parafol12-97和Parafol 14-97出售,以及还有其混合物;十一烷-十三烷混合物,由Cognis公司的专利申请WO 2008/155 059的实施例1和2中获得的正十一烷(C11)和正十三烷(C13)的混合物,及其混合物,
-短链酯(总共含有3至8个碳原子),诸如乙酸乙酯、乙酸甲酯、乙酸丙酯或乙酸正丁酯,
-植物来源的基于烃的油,诸如由甘油的脂肪酸酯组成的甘油三酯,其脂肪酸可具有从C4至C24变化的链长,这些链可能为直链或支链和饱和或不饱和的;这些油尤其是庚酸或辛酸甘油三酯,或者是小麦胚芽油、葵花油、葡萄籽油、芝麻籽油、玉米油、杏仁油、蓖麻油、乳木果油、鳄梨油、橄榄油、大豆油、甜杏仁油、棕榈油、菜籽油、棉籽油、榛果油、澳洲坚果油、荷荷巴油、紫花苜蓿油、罂粟油、南瓜油、西葫芦油、黑加仑油、月见草油、小米油、大麦油、藜麦油、黑麦油、红花油、烛果油、西番莲油和麝香玫瑰油;牛油树脂;或者辛酸/癸酸甘油三酯,例如由Stéarineries Dubois公司出售的那些或由Dynamit Nobel公司以名称Miglyol 810®、812®和818®出售的那些,
-含有10至40个碳原子的合成醚;
-矿物或合成来源的直链或支链烃,诸如石油膏、聚癸烯、氢化聚异丁烯诸如Parleam®、角鲨烷和液体石蜡,及其混合物,
-合成酯,诸如式R1COOR2的油,其中R1代表含有1至40个碳原子的直链或支链脂肪酸残基或含有6至40个碳原子的芳族酸残基,并且R2代表含有1至40个碳原子的基于支链烃的链,条件是R1 + R2 > 10,例如purcellin油(辛酸鲸蜡硬脂酯)、肉豆蔻酸异丙酯、棕榈酸异丙酯、C12-C15烷基苯甲酸酯、月桂酸己酯、己二酸二异丙酯、异壬酸异壬酯、棕榈酸2-乙基己酯、异硬脂酸异硬脂酯、月桂酸2-己基癸酯、棕榈酸2-辛基癸酯、肉豆蔻酸2-辛基十二烷醇酯、烷基或多烷基庚酸酯、辛酸酯、癸酸酯或蓖麻油酸酯,诸如丙二醇二辛酸酯;羟基化酯,诸如乳酸异硬脂酯、苹果酸二异硬脂酯和乳酸2-辛基十二烷醇酯;多元醇酯和季戊四醇酯,
-在室温下为液体、具有含有12至26个碳原子的支化和/或不饱和碳基链的脂肪醇,例如辛基十二烷醇、异硬脂醇、油醇、2-己基癸醇、2-丁基辛醇和2-十一烷基十五烷醇,
-C2-C8单羧酸或多羧酸和C2-C8醇的任选羟基化的单酯、二酯或三酯,特别是:
-C2-C8羧酸和C2-C8醇的任选羟基化的单酯,诸如月桂酰肌氨酸异丙酯,
-C2-C8二羧酸和C2-C8醇的任选羟基化的二酯,诸如己二酸二异丙酯、己二酸2-二乙基己酯、己二酸二丁酯、己二酸二异硬脂酯或琥珀酸2-二乙基己酯,
-C2-C8三羧酸和C2-C8醇的任选羟基化的三酯,诸如柠檬酸酯,诸如柠檬酸三辛酯、柠檬酸三乙酯、乙酰柠檬酸三丁酯、柠檬酸三丁酯或乙酰柠檬酸三丁酯;
-其混合物。
优选地,基于烃的油选自C2-C8单羧酸或多羧酸和C2-C8醇的任选羟基化的单酯、二酯或三酯。
在优选实施方案中,油相含有月桂酰肌氨酸异丙酯和乙酰柠檬酸三丁酯作为油。
优选地,基于烃的油代表脂肪相中的所有油,或相对于脂肪相中可存在的额外的油计以占优势的重量含量存在。
优选地,基于烃的油以相对于两相组合物的总重量计在0.5重量%至10重量%、优选0.8重量%至8重量%、更优选1重量%至5重量%范围内的量存在。
非离子表面活性剂
根据本发明的第一方面,两相组合物的脂肪相含有选自甘油的氧化烯化脂肪酸酯的至少一种非离子表面活性剂。
表面活性剂通常为两亲性的有机化合物,这表示它们含有疏水基团(其尾部)和亲水基团(其头部)二者。“非离子表面活性剂”表示在其头部不具有带电基团的表面活性剂(即,亲水基团的电荷为中性)。
根据本发明,甘油的氧化烯化脂肪酸酯的氧化烯链优选为氧乙烯链。
更优选地,其可含有例如1至150个氧化烯且尤其是氧乙烯基团,且优选2至100个氧化烯且尤其是氧乙烯基团。
可提及的甘油的氧化烯化脂肪酸酯的实例更特别包括(INCI名称)PEG-20甘油三异硬脂酸酯、PEG-7甘油椰油酸酯、及其混合物。
作为非离子表面活性剂的例示,可提及PEG-20甘油三异硬脂酸酯,诸如由NihonEmulsion公司以商品名Emalex Gwis-320EX出售的那些。
该组合物还可含有一种或更多种其它非离子表面活性剂。
可提及的其它非离子表面活性剂的实例包括失水山梨醇的氧化烯化脂肪酸酯、脂肪酸和多元醇的酯;脂肪醇和多元醇的氧化烯化或非氧化烯化醚,及其混合物。
可提及的这种类型的表面活性剂更特别包括:
-失水山梨醇的氧乙烯化脂肪酸酯,诸如(INCI名称)聚山梨醇酯20、聚山梨醇酯65、聚山梨醇酯85、PEG-5失水山梨醇异硬脂酸酯、PEG-20失水山梨醇三异硬脂酸酯、PEG-20失水山梨醇异硬脂酸酯、PEG-40失水山梨醇七油酸酯、PEG-20失水山梨醇四油酸酯和PEG-20失水山梨醇三油酸酯;
-聚甘油的脂肪酸酯,诸如(INCI名称)聚甘油-3三异硬脂酸酯、聚甘油-10二异硬脂酸酯、聚甘油-6异硬脂酸酯、聚甘油-3二异硬脂酸酯、聚甘油-10三油酸酯或聚甘油-10三月桂酸酯;
-聚乙二醇的脂肪酸酯,诸如(INCI名称)PEG-8硬脂酸酯、PEG-6油酸酯、PEG-6异硬脂酸酯、PEG-12异硬脂酸酯、PEG-12二异硬脂酸酯、PEG-8异硬脂酸酯、PEG-8二异硬脂酸酯或PEG-10异硬脂酸酯;
-氧化烯化、尤其是氧乙烯化和/或氧丙烯化、更特别是氧乙烯化的脂肪烷基醚,例如鲸蜡硬脂醇聚醚-12和鲸蜡硬脂醇聚醚-20 (INCI名称),以及还有含有它们的混合物,例如由Cognis公司以名称Emulgade CM出售的混合物(鲸蜡硬脂醇异壬酸酯、鲸蜡硬脂醇聚醚-20、鲸蜡硬脂醇、硬脂酸甘油酯、甘油、鲸蜡硬脂醇聚醚-12和棕榈酸鲸蜡酯的混合物);
-及其混合物。
可提及聚山梨醇酯20,诸如由Croda公司以商品名Tween™ 20-LQ-(AP)出售的那些。
有利地,非离子表面活性剂以相对于两相组合物的总重量计在0.1重量%至1重量%、优选0.1重量%至0.8重量%、优选0.15重量%至0.5重量%范围内的量存在。
化妆品活性剂
取决于最终目的,视其亲水或亲脂性质而定,两相组合物可在一个或另一个相中包含化妆品活性剂。
作为可用于本发明的两相组合物中的化妆品活性剂,尤其当该两相组合物为护肤组合物时,可提及的实例包括:酶、类黄酮、润肤剂(moisturizer)、抗炎剂、维生素、保湿剂(moisturing agent)、增白或美白剂、脱皮剂(peeling agent)、抗衰老剂、抗氧化剂、脱色剂、α-羟基酸、类视色素、抗菌活性剂、张紧剂、神经酰胺、精油、UV遮蔽剂(或防晒剂)、及其混合物。
对于本领域技术人员而言,基于两相组合物的最终用途调节化妆品活性剂的量是容易的。
辅剂或添加剂
根据本发明的组合物还可含有常规化妆品辅剂或添加剂,取决于它们的亲水或亲脂性质,其将处于一个或另一个相中,例如:鳌合剂(例如乙二胺二琥珀酸三钠)、香料、防腐剂(例如苯氧乙醇)和杀菌剂、遮光剂、染料、助水溶剂、增溶剂(例如PPG-6-癸基十四醇聚醚-30、甲基葡糖醇聚醚-20)、软化剂、缓冲剂、电解质诸如氯化钠、或pH调节剂(例如柠檬酸或氢氧化钠)、及其混合物。
根据本发明的实施方案,两相组合物在水相中含有苯氧乙醇作为防腐剂。
当存在于两相组合物中时,相对于水相的总重量计,防腐剂通常占0.1重量%至1重量%、优选0.2重量%至0.8重量%、且更好为0.3重量%至0.6重量%。
不必说,本领域技术人员将慎重选择加入根据本发明的组合物的任选辅剂,以使得与根据本发明的组合物固有相关的有利性质不受或基本上不受所设想添加的不利影响。
根据特别优选的实施方案,相对于两相组合物的总重量计,用于局部施用的两相组合物包含:
a)水相,其含有:
(i)0.3重量%至1重量%的至少一种牛磺酸盐表面活性剂,其选自:甲基月桂酰基牛磺酸钠、甲基肉豆蔻酰基牛磺酸钠、甲基椰油酰基牛磺酸钠、甲基油酰基牛磺酸钠、甲基月桂酰基牛磺酸钾、甲基肉豆蔻酰基牛磺酸钾、甲基椰油酰基牛磺酸钾、甲基油酰基牛磺酸钾、甲基月桂酰基牛磺酸铵、甲基肉豆蔻酰基牛磺酸铵、甲基椰油酰基牛磺酸铵和甲基油酰基牛磺酸铵;和
(ii)0.3重量%至0.6重量%的至少一种亲脂性增稠剂,其选自:聚丙烯酰基二甲基牛磺酸铵、黄原胶、瓜尔胶、阿拉伯树胶、刺槐豆胶、金合欢胶;和
b)脂肪相,其含有:
(i)1重量%至5重量%的至少一种烃油,其选自C2-C8单羧酸或多羧酸和C2-C8醇的任选羟基化的单酯、二酯或三酯;和
(ii)0.15重量%至0.5重量%的至少一种非离子表面活性剂,其选自PEG-20甘油三异硬脂酸酯、PEG-7甘油椰油酸酯、及其混合物;
其中水相和/或脂肪相包含选自以下的化妆品活性剂:酶、类黄酮、润肤剂、抗炎剂、维生素、保湿剂、增白或美白剂、脱皮剂、抗衰老剂、抗氧化剂、脱色剂、α-羟基酸、类视色素、抗菌活性剂、张紧剂、神经酰胺、精油、UV遮蔽剂(或防晒剂)、及其混合物;
其中水相和脂肪相是分开的。
上述两相组合物可按已知方式在具有单室的瓶子中调理。然后使用者可摇晃瓶子,之后将其内容物倒在化妆棉上。
在优选实施方案中,将两相组合物容纳在包括容器和移液器的包装装置中,其中将水相容纳在容器中并将脂肪相容纳在移液器中。
方法和用途
本发明的另一目的是提供用于护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部的方法。
根据本发明的两相组合物可用于任何局部施用。
特别地,该两相组合物可用于非治疗性方法,诸如用于护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部的美容方法。
因此,根据第二方面,本发明提供用于护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部的方法,其包括摇晃如上所述的两相组合物以形成水包油乳液并将该乳液施用于角蛋白材料。
除非另外指定,否则本发明中所有的百分数都指代重量百分数。
下文的实施例旨在例示根据本发明的两相组合物,但不以任何方式限制本发明的范围。化合物的名称以化学名称或INCI名称给出。
实施例
实施例1:制备两相组合物
在该实施例中,制备了发明配方和比较配方的两相组合物。
*:使用柠檬酸将pH调节至4.5。
首先,根据下列配方制备以上发明配方和比较配方的两相组合物的脂肪相(除非另外指示,否则含量以活性材料的重量百分数表示):
程序:将脂肪相的成分冷混合。
根据下列配方制备以上发明配方和比较配方的两相组合物的水相(除非另外指示,否则含量以活性材料的重量百分数表示):
程序:将水相的成分冷混合。
由此获得了由两个分开的相组成的两相组合物。
实施例2:评估两相组合物
观察摇晃前发明配方1的两相组合物的水相与脂肪相之间的界面。
在用手摇晃时,评估由实施例1中制备的发明配方和比较配方的每种两相组合物获得的乳液的稳定性。
使用Binder烘箱(USA),通过将乳液留在烘箱中2个月来进行25℃下持续2个月的稳定性试验。
使用ATLAC (AMETEK Measurement and Calibration Technologies)来进行持续24小时的光稳定性试验。
在下文列出发明配方和比较配方的两相组合物的试验结果。
N.A.:未观察。
观察到在用手摇晃后,根据发明配方1的两相组合物显示出良好的稳定性、具有可见油滴的稳定和均匀分布的珍珠状外观,并且即使在室温下放置2个月后也无相分离。
Claims (15)
1.一种用于局部施用的两相组合物,其包含:
a)含有至少一种牛磺酸盐表面活性剂和至少一种亲水性增稠剂的水相;和
b)含有至少一种烃油和选自甘油的氧化烯化脂肪酸酯的至少一种非离子表面活性剂的脂肪相,
其中所述水相和所述脂肪相是分开的。
2.根据权利要求1所述的两相组合物,其中水相以相对于所述两相组合物的总重量计在50重量%至99重量%、优选55重量%至98重量%、甚至更优选60重量%至97重量%范围内的量存在。
4.根据权利要求1-3中任一项所述的两相组合物,其中所述牛磺酸盐表面活性剂选自:甲基月桂酰基牛磺酸钠、甲基肉豆蔻酰基牛磺酸钠、甲基椰油酰基牛磺酸钠、甲基油酰基牛磺酸钠、甲基月桂酰基牛磺酸钾、甲基肉豆蔻酰基牛磺酸钾、甲基椰油酰基牛磺酸钾、甲基油酰基牛磺酸钾、甲基月桂酰基牛磺酸铵、甲基肉豆蔻酰基牛磺酸铵、甲基椰油酰基牛磺酸铵和甲基油酰基牛磺酸铵。
5.根据权利要求1-4中任一项所述的两相组合物,其中所述牛磺酸盐表面活性剂以相对于所述两相组合物的总重量计0.1重量%至1重量%、优选0.2重量%至1重量%、更优选0.3重量%至1重量%的量存在。
6.根据权利要求1-5中任一项所述的两相组合物,其中所述亲脂性增稠剂选自2-丙烯酰胺基-2-甲基丙磺酸均聚物和共聚物,以及多糖生物聚合物。
7.根据权利要求1-6中任一项所述的两相组合物,其中所述亲脂性增稠剂以相对于所述两相组合物的总重量计0.1重量%至2重量%、优选0.2重量%至1.5重量%、更优选0.3重量%至1重量%的量存在。
8.根据权利要求1-7中任一项所述的两相组合物,其中所述脂肪相以相对于所述两相组合物的总重量计在1重量%至50重量%、优选2重量%至45重量%、甚至更优选3重量%至40重量%范围内的量存在。
9.根据权利要求1-8中任一项所述的两相组合物,其中所述基于烃的油选自C2-C8三羧酸和C2-C8醇的任选羟基化的三酯。
10.根据权利要求1-9中任一项所述的两相组合物,其中所述基于烃的油以相对于所述两相组合物的总重量计在0.5重量%至10重量%、优选0.8重量%至8重量%、更优选1重量%至5重量%范围内的量存在。
11.根据权利要求1-10中任一项所述的组合物,其中所述非离子表面活性剂选自含有2至100个氧乙烯基的甘油的氧化烯化脂肪酸酯。
12.根据权利要求1-11中任一项所述的两相组合物,其中所述非离子表面活性剂以相对于所述两相组合物的总重量计在0.1重量%至1重量%、优选0.1重量%至0.8重量%、优选0.15重量%至0.5重量%范围内的量存在。
13.根据权利要求1-12中任一项所述的两相组合物,其在所述水相和/或所述脂肪相中还包含选自以下的化妆品活性剂:酶、类黄酮、润肤剂、抗炎剂、维生素、保湿剂、增白或美白剂、脱皮剂、抗衰老剂、抗氧化剂、脱色剂、α-羟基酸、类视色素、抗菌活性剂、张紧剂、神经酰胺、精油、UV遮蔽剂(或防晒剂)、及其混合物。
14.一种用于局部施用的两相组合物,相对于所述两相组合物的总重量计,其包含:
a)水相,其含有:
(i)0.3重量%至1重量%的至少一种牛磺酸盐表面活性剂,其选自:甲基月桂酰基牛磺酸钠、甲基肉豆蔻酰基牛磺酸钠、甲基椰油酰基牛磺酸钠、甲基油酰基牛磺酸钠、甲基月桂酰基牛磺酸钾、甲基肉豆蔻酰基牛磺酸钾、甲基椰油酰基牛磺酸钾、甲基油酰基牛磺酸钾、甲基月桂酰基牛磺酸铵、甲基肉豆蔻酰基牛磺酸铵、甲基椰油酰基牛磺酸铵和甲基油酰基牛磺酸铵;和
(ii)0.3重量%至0.6重量%的至少一种亲脂性增稠剂,其选自:聚丙烯酰基二甲基牛磺酸铵、黄原胶、瓜尔胶、阿拉伯树胶、刺槐豆胶、金合欢胶;和
b)脂肪相,其含有:
(i)1重量%至5重量%的至少一种烃油,其选自C2-C8单羧酸或多羧酸和C2-C8醇的任选羟基化的单酯、二酯或三酯;和
(ii)0.15重量%至0.5重量%的至少一种非离子表面活性剂,其选自PEG-20甘油三异硬脂酸酯、PEG-7甘油椰油酸酯及其混合物;
其中所述水相和/或所述脂肪相包含选自以下的化妆品活性剂:酶、类黄酮、润肤剂、抗炎剂、维生素、保湿剂、增白或美白剂、脱皮剂、抗衰老剂、抗氧化剂、脱色剂、α-羟基酸、类视色素、抗菌活性剂、张紧剂、神经酰胺、精油、UV遮蔽剂(或防晒剂)、及其混合物;
其中所述水相和所述脂肪相是分开的。
15.一种用于护理和/或化妆角蛋白材料,诸如皮肤,特别是脸部、嘴唇和/或眼部的方法,其包括摇晃根据权利要求1-14中任一项所述的两相组合物以形成水包油乳液并将所述乳液施用于所述角蛋白材料。
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