CN114712465A - Tabletting composition containing radix angelicae powder and preparation method thereof - Google Patents
Tabletting composition containing radix angelicae powder and preparation method thereof Download PDFInfo
- Publication number
- CN114712465A CN114712465A CN202210309829.4A CN202210309829A CN114712465A CN 114712465 A CN114712465 A CN 114712465A CN 202210309829 A CN202210309829 A CN 202210309829A CN 114712465 A CN114712465 A CN 114712465A
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- China
- Prior art keywords
- powder
- tabletting
- radix angelicae
- composition
- raw
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
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Classifications
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Abstract
The invention relates to a tabletting composition containing radix angelicae powder and a preparation method thereof, the composition comprises 10-25% of radix angelicae powder, 10-25% of dandelion powder, 10-25% of fresh reed root powder, 10-25% of rose powder with double petals, 5-15% of orange peel concentrated powder, 5-15% of chitosan oligosaccharide, 2-6% of sorbitol, 2-6.5% of isomalt, 1-8% of galacto-oligosaccharide, 1-8% of selenium-enriched malt powder, 1-8% of licorice powder, 1-8% of platycodon grandiflorum powder, 0.5-5% of honeysuckle powder, 0.5-5% of chrysanthemum powder, 0.5-5% of Chinese wolfberry fruit powder, 0.5-5% of rhizoma polygonati powder, 0.1-3% of maltodextrin powder and 0.05-2% of magnesium stearate; the tabletting composition provided by the invention can improve human body microcirculation, promote metabolism, regulate qi, relieve depression, calm mood, relieve dysphoria and the like, and is low in hygroscopicity and beneficial to stable storage.
Description
Technical Field
The invention belongs to the technical field of medicines, and particularly relates to a tabletting composition containing radix angelicae powder and a preparation method thereof.
Technical Field
With the acceleration of modern life rhythm, work, life pressure and the like are easy to cause people to have bad emotion, and more health problems of people influence endocrine and metabolic disorders and further influence various aspects of the body, such as low immunity and the like. Endocrine dyscrasia can cause metabolic disturbance of body organs, and the patients enter into malignant circulation, even serious patients can cause diseases such as tumors and cancers, so that prevention and auxiliary conditioning for the people are very important, and the safety and the effect of the people are required to be ensured.
Modern scientific research shows that Chinese herbal medicines have unique advantages in preventing, assisting and treating the disease, scientific research shows that the Chinese patent medicine has small side effect and is safe, the damage of the Chinese herbal medicines to liver and kidney is small, most medicines enter blood through gastrointestinal absorption, and metabolites of the medicines must be detoxified by liver, so that the key is to select effective and safe medicine-food homologous substances, and effective and safe and reliable compositions are combined among different substances. Chinese patent CN 111494534A discloses a traditional Chinese medicine composition for treating breast nodules and a preparation method thereof, wherein the composition comprises 25-30 parts of dandelion, 5-10 parts of fingered citron, 5-10 parts of honeysuckle, 5-10 parts of rose with double petals, 5-10 parts of mint, 5-8 parts of liquorice, 5-8 parts of scallion beard, 5-10 parts of walnut kernel and 17-22 parts of brown sugar, and can effectively regulate female endocrine and relieve and treat breast nodules; chinese patent CN106974280A discloses an instant porridge for restoring the balance of intestinal flora of breast nodule patients and a preparation method thereof, the instant porridge comprises 4-6 parts of hypsizigus marmoreus, 4-6 parts of phragmitis, 4-6 parts of kelp, 4-6 parts of poria cocos, 2-3 parts of lucid ganoderma, 2-3 parts of dandelion, 2-3 parts of grifola frondosa, 2-3 parts of hericium erinaceus, 2-3 parts of cordyceps militaris, 2-3 parts of agaricus blazei murill, 30-40 parts of wheat bran, 70-80 parts of corn and 30-40 parts of hypsizigus marmoreus cellulose. In summary, there is still a technical gap in the prior art for solving the problems of moisture absorption of traditional Chinese medicine components and traditional Chinese medicine preparations, and further research is needed.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides a tabletting composition containing radix angelicae powder and a preparation method thereof;
the composition comprises radix angelicae powder, dandelion powder, fresh reed root powder, rose powder with double petals, orange peel concentrated powder, chitosan oligosaccharide, sorbitol, isomaltitol, galactooligosaccharide, selenium-enriched malt powder, liquorice, platycodon grandiflorum powder, honeysuckle powder, chrysanthemum powder, medlar fruit powder, yellow essence powder, maltodextrin powder and magnesium stearate;
further, the tabletting composition comprises the following components in percentage by mass:
10-25% of radix angelicae powder, 10-25% of dandelion powder, 10-25% of fresh reed root powder, 10-25% of bivalvia red rose pollen, 5-15% of orange peel concentrated powder, 5-15% of chitosan oligosaccharide, 2-10% of sorbitol, 1-6% of isomaltulose, 1-8% of galactooligosaccharide, 1-8% of selenium-enriched malt powder, 1-8% of licorice powder, 1-8% of platycodon root powder, 0.5-5% of honeysuckle powder, 0.5-5% of chrysanthemum powder, 0.5-5% of wolfberry fruit powder, 0.5-5% of rhizoma polygonati powder, 0.1-3% of maltodextrin powder and 0.05-2% of magnesium stearate.
Preferably, the mass ratio of the radix angelicae powder to the fresh reed root powder to the dandelion powder is 1: 0.5-2: 0.6 to 1.6; the mass ratio of the honeysuckle powder to the chrysanthemum powder to the medlar fruit powder is 1: 0.51-1.75: 0.58-1; the mass ratio of the selenium-rich malt flour to the liquorice to the rhizoma polygonati powder is 1: 0.64-1.15: 0.25-0.5; the mass ratio of the rose powder, the orange peel concentrated powder, the platycodon root powder and the rhizoma polygonati powder is 1: 0.375-0.75: 0.25-0.5: 0.0625-0.25; the mass ratio of the chitosan oligosaccharide, the galacto-oligosaccharide and the maltodextrin powder is 1: 0.33-0.8: 0.067-0.2; the mass ratio of the sorbitol to the isomalt is 1: 0.67-1.5.
The invention also provides a preparation method of the tabletting composition containing the radix angelicae powder, which comprises the following steps:
s1, checking, weighing and preparing materials
Inspecting the raw and auxiliary materials and the inner packaging material, accurately weighing the raw and auxiliary materials according to the formula amount for later use after the raw and auxiliary materials and the inner packaging material are inspected to be qualified, and sieving the raw and auxiliary materials by 40-60 meshes;
s2, granulating and drying
Putting radix angelicae powder, dandelion powder, fresh reed rhizome powder, rose powder with double petals, orange peel concentrated powder, chitosan oligosaccharide, isomaltitol, galactooligosaccharide, selenium-rich malt powder, licorice powder, platycodon root powder, honeysuckle powder, chrysanthemum powder, medlar fruit powder, sealwort powder and maltodextrin powder into a granulating pot according to the formula amount, granulating by using blended alcohol (75-95%), and drying the granulated wet granules to obtain a material A;
s3, mixing, and tabletting
Putting the material A, sorbitol and magnesium stearate into a total mixing pot, mixing until the color of the material is uniform, and tabletting by adopting a die to obtain a tabletting composition;
s4, internal packing, external packing, inspection and warehousing
And (3) subpackaging the tablets according to the packaging requirement, labeling the tablets according to the packaging requirement, boxing the tablets, sampling the products, inspecting the products to be qualified, and warehousing the packaged finished products.
Further, the moisture content of the dried particles in the step S2 is controlled to be 0.5-2 wt%.
Further, the mixing time in the step S3 is 20-40 min.
Further, the tablet weight obtained in the step S3 is 600-800 mg, and the difference of the tablet weight is +/-5%.
Compared with the prior art, the invention has the following beneficial effects:
(1) the tabletting composition prepared by the invention can accelerate metabolism of a human body, can improve microcirculation of the human body, has the effects of clearing liver and improving eyesight, removing in-vivo sore and carbuncle pyogenic infections, regulating qi and relieving depression, soothing mood, relieving dysphoria and promoting metabolism, is rich in amino acid, protein, vitamin C, vitamin B, calcium, zinc, potassium, iron and other trace elements required by the human body, can supplement the trace elements required by the human body, and is beneficial to promoting microcirculation of the human body.
(2) The composition provided by the invention has good blending performance, and the prepared tablet has good stability, and particularly can reduce the oxidation of chitosan oligosaccharide and other components with strong reducing property in the air, reduce the moisture absorption and oxidation of traditional Chinese medicine components, and improve the storage stability.
Detailed Description
Experimental procedures according to the invention, in which no particular conditions are specified in the following examples, are generally carried out under conventional conditions, or under conditions recommended by the manufacturer. The various chemicals used in the examples are commercially available.
Unless defined otherwise, all technical and scientific terms used herein have the same meaning as commonly understood by one of ordinary skill in the art to which this invention belongs. The terminology used in the description of the invention herein is for the purpose of describing particular embodiments only and is not intended to be limiting of the invention.
The terms "comprises" and "comprising," as well as any variations thereof, are intended to cover non-exclusive inclusions. For example, a process, method, apparatus, article, or device that comprises a list of steps is not limited to only those steps or modules listed, but may alternatively include other steps not listed or inherent to such process, method, article, or device.
In order to make the objects, technical solutions and advantages of the present invention more apparent, the present invention is further described in detail with reference to the following embodiments. It should be understood that the description is intended to be exemplary only, and is not intended to limit the scope of the present invention. Moreover, in the following description, descriptions of well-known structures and techniques are omitted so as to not unnecessarily obscure the concepts of the present invention.
The invention is further described in the following examples, which are not intended to limit the scope of the invention.
EXAMPLE 1 preparation of a tabletted composition according to the invention
The formula of the tabletting composition containing the radix angelicae powder is shown in table 1;
table 1:
the preparation method of the tabletting composition comprises the following steps:
s1, checking, weighing and preparing materials
Inspecting the raw and auxiliary materials and the inner packaging material, accurately weighing the raw and auxiliary materials according to the formula amount for later use after the raw and auxiliary materials and the inner packaging material are inspected to be qualified, and sieving the raw and auxiliary materials by 40-60 meshes;
s2, granulating and drying
Putting radix angelicae powder, dandelion powder, fresh reed rhizome powder, rose powder with double petals, orange peel concentrated powder, chitosan oligosaccharide, isomaltitol, galactooligosaccharide, selenium-rich malt powder, licorice powder, platycodon root powder, honeysuckle powder, chrysanthemum powder, medlar fruit powder, rhizoma polygonati powder and maltodextrin powder into a granulating pot according to the formula amount, granulating by using blended alcohol (75%), drying the granulated wet granules, and controlling the water content to be 0.1 +/-0.05 wt% to obtain a material A;
s3, mixing, tabletting and coating
Putting the material A, sorbitol and magnesium stearate into a total mixing pot, mixing for 25min until the color of the material is uniform, and tabletting by using a punch die to obtain tablets with the weight of 800mg +/-5%;
s4, inner packaging, outer packaging, inspection and warehousing
And subpackaging the tabletting composition according to the packaging requirement, labeling the product according to the packaging requirement, boxing the product, sampling and inspecting the product to be qualified, and warehousing the packaged finished product.
EXAMPLE 2 preparation of a tabletted composition according to the invention
The formula of the tabletting composition containing the radix angelicae powder is shown in table 2;
table 2:
the preparation method of the tabletting composition comprises the following steps:
s1, checking, weighing and preparing materials
Inspecting the raw and auxiliary materials and the inner packaging material, accurately weighing the raw and auxiliary materials according to the formula amount for later use after the raw and auxiliary materials and the inner packaging material are inspected to be qualified, and sieving the raw and auxiliary materials by 40-60 meshes;
s2, granulating and drying
Putting radix angelicae powder, dandelion powder, fresh reed rhizome powder, rose powder with double petals, orange peel concentrated powder, chitosan oligosaccharide, isomaltitol, galactooligosaccharide, selenium-rich malt powder, licorice powder, platycodon root powder, honeysuckle powder, chrysanthemum powder, medlar fruit powder, rhizoma polygonati powder and maltodextrin powder into a granulating pot according to the formula amount, granulating by using blended alcohol (85%), drying the granulated wet granules, and controlling the water content to be 0.1 +/-0.05 wt% to obtain a material A;
s3, mixing, tabletting and coating
Putting the material A, sorbitol and magnesium stearate into a total mixing pot, mixing for 25min until the color of the material is uniform, and tabletting by using a punching die to obtain tablets with the weight of 750mg +/-5%;
s4, internal packing, external packing, inspection and warehousing
And subpackaging the tabletting composition according to the packaging requirement, labeling the product according to the packaging requirement, boxing the product, sampling and inspecting the product to be qualified, and warehousing the packaged finished product.
EXAMPLE 3 preparation of a tabletted composition according to the invention
The formula of the tabletting composition containing the radix angelicae powder is shown in table 3;
table 3:
the preparation method of the tabletting composition comprises the following steps:
s1, checking, weighing and preparing materials
Inspecting the raw and auxiliary materials and the inner packaging material, accurately weighing the raw and auxiliary materials according to the formula amount for later use after the raw and auxiliary materials and the inner packaging material are inspected to be qualified, and sieving the raw and auxiliary materials by 40-60 meshes;
s2, granulating and drying
Putting radix angelicae powder, dandelion powder, fresh reed rhizome powder, rose powder with double petals, orange peel concentrated powder, chitosan oligosaccharide, isomaltitol, galactooligosaccharide, selenium-rich malt powder, licorice powder, platycodon root powder, honeysuckle powder, chrysanthemum powder, medlar fruit powder, rhizoma polygonati powder and maltodextrin powder into a granulating pot according to the formula amount, granulating by using blended alcohol (90%), drying the granulated wet granules, and controlling the water content to be 0.15 +/-0.05 wt% to obtain a material A;
s3, mixing, tabletting and coating
Putting the material A, sorbitol and magnesium stearate into a total mixing pot, mixing for 40min until the color of the material is uniform, and tabletting by using a punch die to obtain tablets with the weight of 780mg +/-5%;
s4, internal packing, external packing, inspection and warehousing
And subpackaging the tabletting composition according to the packaging requirement, labeling the product according to the packaging requirement, boxing the product, sampling and inspecting the product to be qualified, and warehousing the packaged finished product.
EXAMPLE 4 preparation of a tabletted composition according to the invention
The formula of the tabletting composition containing the radix angelicae powder is shown in table 4;
table 4:
the preparation method of the tabletting composition comprises the following steps:
s1, checking, weighing and preparing materials
Inspecting the raw and auxiliary materials and the inner packaging material, accurately weighing the raw and auxiliary materials according to the formula amount for later use after the raw and auxiliary materials and the inner packaging material are inspected to be qualified, and sieving the raw and auxiliary materials by 40-60 meshes;
s2, granulating and drying
Putting radix angelicae powder, dandelion powder, fresh reed rhizome powder, rose powder with double petals, orange peel concentrated powder, chitosan oligosaccharide, isomaltitol, galactooligosaccharide, selenium-rich malt powder, licorice powder, platycodon root powder, honeysuckle powder, chrysanthemum powder, medlar fruit powder, rhizoma polygonati powder and maltodextrin powder into a granulating pot according to the formula amount, granulating by using blended alcohol (95%), drying the granulated wet granules, and controlling the water content to be 0.18 +/-0.05 wt% to obtain a material A;
s3, mixing, tabletting and coating
Putting the material A, sorbitol and magnesium stearate into a total mixing pot, mixing for 40min until the color of the material is uniform, and tabletting by using a punch die to obtain tablets with the weight of 600mg +/-5%;
s4, internal packing, external packing, inspection and warehousing
And subpackaging the tabletting composition according to the packaging requirement, labeling the product according to the packaging requirement, boxing the product, sampling and inspecting the product to be qualified, and warehousing the packaged finished product.
Test example I, test of physical and chemical Properties of tableting composition of the present invention
The hardness, friability and moisture absorption rate of the tabletted compositions prepared in the embodiments 1 to 4 of the invention are measured by adopting a detection method and a standard in the fourth part of the Chinese pharmacopoeia, the moisture absorption rate is weighed for 10 hours in an environment with 25 ℃ and 70% RH, the moisture absorption rate of the tablet is calculated according to the mass difference, and the specific results are shown in Table 5;
table 5:
the content of the tabletting composition prepared by the invention contains more traditional Chinese medicine components, the hygroscopicity is too high, the caking and agglomeration are easy to occur due to moisture, the disintegration process is difficult to uniformly disperse, the dissolution rate is reduced, and the drug effect is reduced, the chitosan oligosaccharide contained in the tabletting composition has stronger reducibility, the composition components are difficult to keep stable due to exposure in the air or oxidation reaction, and other physicochemical properties are also seriously influenced.
It should be noted that specific features, structures, materials or characteristics described in this specification may be combined in any combination, all possible combinations of technical features in the above embodiments are not described in order to simplify the description, and those skilled in the art may combine and combine features of different embodiments and features of different embodiments described in this specification without contradiction.
The above-mentioned embodiments only express several embodiments of the present invention, and the description thereof is specific and detailed, but not to be understood as limiting the scope of the invention. It should be noted that, for a person skilled in the art, several variations and modifications can be made without departing from the inventive concept, which falls within the scope of the present invention. Therefore, the protection scope of the present patent shall be subject to the appended claims.
Claims (10)
1. The tabletting composition containing radix angelicae powder is characterized by consisting of a content and a coating, wherein the content comprises the following raw materials in percentage by mass: 10-25% of radix angelicae powder, 10-25% of dandelion powder, 10-25% of fresh reed root powder, 10-25% of bivalvia red rose pollen, 5-15% of orange peel concentrated powder, 5-15% of chitosan oligosaccharide, 2-6% of sorbitol, 2-6.5% of isomaltulose, 1-8% of galactooligosaccharide, 1-8% of selenium-enriched malt powder, 1-8% of licorice powder, 1-8% of platycodon root powder, 0.5-5% of honeysuckle powder, 0.5-5% of chrysanthemum powder, 0.5-5% of wolfberry fruit powder, 0.5-5% of rhizoma polygonati powder, 0.1-3% of maltodextrin powder and 0.05-2% of magnesium stearate.
2. The composition as claimed in claim 1, wherein the weight ratio of the radix angelicae powder, the fresh reed rhizome powder and the dandelion powder is 1: 0.5-2: 0.6 to 1.6.
3. The composition according to claim 1, wherein the mass ratio of the honeysuckle powder, the chrysanthemum powder and the medlar fruit powder is 1: 0.51-1.75: 0.58-1.
4. The composition according to claim 1, wherein the mass ratio of the selenium-rich malt flour to the liquorice to the rhizoma polygonati is 1: 0.64-1.15: 0.25-0.5.
5. The composition as claimed in claim 1, wherein the mass ratio of the rose powder with double petals to the orange peel concentrated powder to the platycodon root powder to the rhizoma polygonati powder is 1: 0.375-0.75: 0.25-0.5: 0.0625-0.25.
6. The composition according to claim 1, wherein the mass ratio of sorbitol to isomalt is 1:0.67 to 1.5.
7. A method for preparing a tabletted composition containing radix Angelicae Dahuricae powder according to any one of claims 1-6, comprising the steps of:
s1, checking, weighing and preparing materials
Inspecting the raw and auxiliary materials and the inner packaging material, accurately weighing the raw and auxiliary materials according to the formula amount for later use after the raw and auxiliary materials and the inner packaging material are inspected to be qualified, and sieving the raw and auxiliary materials by 40-60 meshes;
s2, granulating and drying
Putting radix angelicae powder, dandelion powder, fresh reed rhizome powder, rose powder with double petals, orange peel concentrated powder, chitosan oligosaccharide, isomaltitol, galactooligosaccharide, selenium-rich malt powder, licorice powder, platycodon root powder, honeysuckle powder, chrysanthemum powder, medlar fruit powder, rhizoma polygonati powder and maltodextrin powder into a granulating pot according to the formula amount, granulating by using blended alcohol, and drying the granulated wet granules to obtain a material A;
s3, mixing and tabletting
Putting the material A, sorbitol and magnesium stearate into a total mixing pot, mixing until the color of the material is uniform, and tabletting by adopting a die to obtain a tabletting composition;
s4, internal packing, external packing, inspection and warehousing
And subpackaging the tabletting composition according to the packaging requirement, labeling the product according to the packaging requirement, boxing the product, sampling and inspecting the product to be qualified, and warehousing the packaged finished product.
8. The method according to claim 7, wherein the moisture content of the dried pellets in step S2 is controlled to 0.5-2 wt%.
9. The method according to claim 7, wherein the mixing time in step S3 is 20-40 min.
10. The method according to claim 7, wherein the tablet weight obtained after tabletting in step S3 is 600-800 mg, and the difference in tablet weight is ± 5%.
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| CN116548612A (en) * | 2023-06-01 | 2023-08-08 | 江中药业股份有限公司 | Composition, hawthorn and dandelion micro-bubble tablet and preparation method thereof |
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| CN109223995A (en) * | 2018-11-06 | 2019-01-18 | 张瑞武 | A kind of pharynx-clearing throat-benefiting Traditional Chinese medicine lozenge |
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| CN116548612A (en) * | 2023-06-01 | 2023-08-08 | 江中药业股份有限公司 | Composition, hawthorn and dandelion micro-bubble tablet and preparation method thereof |
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Application publication date: 20220708 |