CN114668707A - Probiotic oral bacteriostatic paste capable of recovering oral peculiar smell - Google Patents

Probiotic oral bacteriostatic paste capable of recovering oral peculiar smell Download PDF

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CN114668707A
CN114668707A CN202210177102.5A CN202210177102A CN114668707A CN 114668707 A CN114668707 A CN 114668707A CN 202210177102 A CN202210177102 A CN 202210177102A CN 114668707 A CN114668707 A CN 114668707A
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oral
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leaching
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李自鹏
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Abstract

The invention discloses a probiotic oral cavity antibacterial paste capable of recovering oral peculiar smell, which relates to the technical field of oral cavity antibacterial pastes and comprises the following raw materials in parts by weight: 30-45 parts of powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant, 1-8 parts of thickener, 2-6 parts of foaming agent, 1.5-2 parts of food-grade surfactant, 12-20 parts of plant extract, 3-10 parts of composite probiotics, 2-7 parts of lactoferrin, 0.5-2 parts of vitamin, 0.5-3 parts of antibacterial peptide, 0.2-3.5 parts of orange peel powder, 2-3 parts of borneol, 0.5-2.5 parts of pseudo-ginseng, 0.1-1 part of flavoring agent and the balance of deionized water; the preparation process of the probiotic oral bacteriostatic paste capable of recovering the peculiar smell of the oral cavity comprises the following steps: (1) preparing a plant extract; (2) and preparing the composite probiotics. The probiotic oral bacteriostatic cream capable of recovering the peculiar smell in the oral cavity is added with plant extract components, composite probiotic components, antibacterial peptide milk, ferritin and other components, and can be matched with breath freshening components to realize the recovery treatment of the peculiar smell in the oral cavity on the basis of treating oral diseases.

Description

Probiotic oral bacteriostatic paste capable of recovering oral peculiar smell
Technical Field
The invention relates to the technical field of oral cavity bacteriostatic paste, in particular to probiotic oral cavity bacteriostatic paste capable of recovering oral peculiar smell.
Background
The oral cavity bacteriostatic paste mainly aims at inhibiting bacteria in the oral cavity, can be used as toothpaste, is a cleaning article commonly used in daily life, is an auxiliary article for brushing teeth, has the functions of rubbing, removing bacterial plaque, cleaning and polishing tooth surfaces and refreshing the oral cavity, and is a substance used for cleaning the surfaces of the teeth together with a toothbrush. Oral malodor refers to unpleasant odor emanating from the oral cavity during breathing, which may be caused by bad life and hygiene habits or by disease factors, and thus may be classified as physiological halitosis and pathological halitosis, and the common diseases include caries, gingivitis, periodontitis, oral ulcer, etc.
The existing probiotic oral cavity antibacterial cream is generally a single type of probiotic components, has poor effect, covers the oral cavity peculiar smell in a way of refreshing the oral cavity smell, and cannot radically recover the oral cavity peculiar smell aiming at oral diseases.
Disclosure of Invention
Aiming at the defects of the prior art, the invention provides the probiotic oral cavity antibacterial paste capable of recovering the oral peculiar smell, and solves the problems that the existing probiotic oral cavity antibacterial paste provided in the background technology is generally a single probiotic component, has poor effect, can cover the oral peculiar smell in a way of refreshing the oral smell, and cannot radically recover the oral peculiar smell aiming at the oral diseases.
In order to achieve the purpose, the invention is realized by the following technical scheme that the probiotic oral cavity antibacterial paste capable of recovering the oral cavity peculiar smell is prepared from the following raw materials in parts by weight:
30-45 parts of powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant, 1-8 parts of thickener, 2-6 parts of foaming agent, 1.5-2 parts of food-grade surfactant, 12-20 parts of plant extract, 3-10 parts of composite probiotics, 2-7 parts of lactoferrin, 0.5-2 parts of vitamin, 0.5-3 parts of antibacterial peptide, 0.2-3.5 parts of orange peel powder, 2-3 parts of borneol, 0.5-2.5 parts of pseudo-ginseng, 0.1-1 part of flavoring agent and the balance of deionized water;
the preparation process of the probiotic oral bacteriostatic paste capable of recovering oral peculiar smell comprises the following steps:
(1) preparing a plant extract;
(2) preparing composite probiotics;
(3) preparing an antibacterial cream substrate;
(4) mixing the antibacterial paste;
(5) and filling the antibacterial paste into a warehouse.
Further, the probiotic oral bacteriostatic cream capable of recovering the peculiar smell of the oral cavity comprises the following specific steps:
(1) preparation of plant extract
S1, primary leaching, namely, respectively cleaning lophatherum gracile, honeysuckle, radix zanthoxyli, pseudo-ginseng and mint with clear water to remove impurities, drying, crushing and sieving to obtain plant powder with a mesh of 50-120, adding purified water 6-8 times of the amount of the plant powder into primary leaching equipment, mixing the plant powder with the purified water, leaching, boiling for 5-10min during the leaching process, and keeping the temperature of 60-80 ℃ for continuous leaching for 60-90min to obtain primary leaching liquid;
S2, secondary leaching, namely conveying the residual filter residue into secondary leaching equipment, then adding purified water in an amount which is 3-5 times that of the filter residue, and leaching for 30-60min at the temperature of 60-80 ℃ to obtain secondary leaching liquor;
s3, mixing and concentrating, mixing the primary leaching liquor and the secondary leaching liquor to obtain mixed liquor, then carrying out centrifugal filtration on the mixed liquor by adopting a centrifugal machine to remove impurities, removing impurities in the mixed liquor, filtering and concentrating to obtain a plant extract;
(2) preparation of composite probiotics
Lactobacillus reuteri, Lactobacillus salivarius and Lactobacillus gasseri are mixed according to a ratio of 2: 1: 1, preparing a composite strain, namely composite probiotics;
(3) preparation of antibacterial cream matrix
Weighing 30-45 parts of powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant and 1.5-2 parts of food-grade surfactant according to the mass parts, adding the powdery abrasive into deionized water, heating and stirring to uniformly mix the powdery abrasive, the adhesive, the humectant and the food-grade surfactant, wherein the stirring temperature is 40-50 ℃, the stirring time is 45-80min, the stirring speed is 800-1500 rpm, fully mixing to obtain a toothpaste matrix, and performing high-temperature sterilization on the toothpaste matrix;
further, the probiotic oral bacteriostatic paste capable of recovering the peculiar smell of the oral cavity further comprises the following specific steps:
(4) and antibacterial cream mixed preparation
Weighing 12-20 parts of plant extract, 3-10 parts of composite probiotics, 2-7 parts of lactoferrin, 0.5-2 parts of vitamin, 0.5-3 parts of antibacterial peptide, 0.2-3.5 parts of orange peel powder, 2-3 parts of borneol and 0.5-2.5 parts of pseudo-ginseng according to parts by mass, fully mixing to form a pasty mixture, adding the pasty mixture into a toothpaste matrix after the temperature of the toothpaste matrix is reduced to normal temperature, adding 0.1-1 part of flavoring agent, 1-8 parts of thickening agent and 2-6 parts of foaming agent, fully mixing at the stirring temperature of 40-50 ℃ for 2200 min at the stirring speed of 1200-rpm, and finally obtaining the mixed paste.
Further, the probiotic oral bacteriostatic paste capable of recovering the peculiar smell of the oral cavity further comprises the following specific steps:
(5) checking the antibacterial cream product
And homogenizing the mixed paste by using a homogenizer to prepare an antibacterial paste body, inspecting the antibacterial paste body to ensure that the antibacterial paste body meets the quality standard, vacuumizing the antibacterial paste body with qualified quality after inspection, filling and sealing, randomly sampling and checking the batch number, the filling amount and the sealing condition, and finally boxing and warehousing and placing in a cool and ventilated place for low-temperature storage.
Further, the plant extract is a mixture of a lophatherum gracile extract, a honeysuckle extract, a zanthoxylum nitidum extract and a mint extract, and the ratio of the lophatherum gracile to the honeysuckle to the zanthoxylum nitidum to the panax notoginseng to the mint in the preparation process of the plant extract is 1:1:2:1: 2.
Further, the finished product of the plant extract has the water content of below 10%.
Further, in the process of preparing the plant extract in the step (1), when the primary extraction of S1 and the secondary extraction of S2 are performed, the primary extraction equipment and the secondary extraction equipment are connected, after the filter residue is obtained after the primary operation, the primary extraction equipment and the secondary extraction equipment are operated at the same time, then the water vapor generated during the boiling of the primary extraction is introduced into the water body of the secondary extraction, the circulation extraction is performed, and meanwhile, ultrasonic generators and transducer vibrators are arranged on the inner walls of the primary extraction equipment and the secondary extraction equipment.
Further, in the preparation process of the antibacterial paste matrix in the step (3), the sterilization temperature of the toothpaste matrix during high-temperature sterilization is 100-120 ℃, and the sterilization time is 15-25 min.
Further, in the process of preparing the antibacterial cream in the step (4) by mixing, the tangerine peel powder, the borneol and the pseudo-ginseng are all in a powdery structure, and the particle size of the powder is 5-30 mu m.
Further, in the process of mixing and preparing the antibacterial cream in the step (4), the feeding of the raw materials in the stirring process is particularly in an intermittent raw material feeding mode.
The invention provides a probiotic oral cavity bacteriostatic paste capable of recovering oral peculiar smell, which has the following beneficial effects:
The probiotic oral cavity bacteriostatic cream capable of recovering oral peculiar smell is added with plant extract components, wherein the plant extract components comprise lophatherum gracile, honeysuckle, double-sided needles, pseudo-ginseng and mint components, the lophatherum gracile has a bacteriostatic action, the honeysuckle can reduce swelling and resist inflammation, clear heat and reduce internal heat, the double-sided needles can be used for bleeding of gum, the double-sided needles have analgesic and antibacterial actions, the pseudo-ginseng can refresh breath and relieve redness of gum, the mint can resist inflammation and inhibit bacteria and has a breath freshening action, the honeysuckle and the pseudo-ginseng can reduce swelling and relieve pain by matching use, resist compression and inhibit bacteria and refresh breath, in the preparation process, water vapor generated in the boiling process of primary leaching is introduced into a water body of secondary leaching, the cyclic leaching can promote the efficiency of the secondary leaching on one hand, the temperature of the secondary leaching is kept, the concentration of the secondary leaching is improved, the waste of resources is avoided, and an ultrasonic generator and a transducer are arranged at the same time, the cell walls of plant components can be effectively broken by utilizing ultrasonic waves, so that the effective components in the extraction solvent and the medicinal materials are quickly contacted and mutually fused, and the subsequent plant extract can be conveniently exerted;
the probiotic oral cavity bacteriostatic paste capable of recovering oral peculiar smell is further added with a compound probiotic component, the compound probiotic is prepared by lactobacillus reuteri, lactobacillus salivarius and lactobacillus gasseri according to a proportion, attached molecules on the surface of the lactobacillus reuteri strain are utilized to be specifically combined with the helicobacter pylori to form a copolymer and then discharged out of an oral cavity, so that the helicobacter pylori in the oral cavity can be inhibited and killed, the lactobacillus salivarius has a good bacteriostatic effect on various aerobic bacteria and anaerobic bacteria in the oral cavity, breeding of harmful strains in the oral cavity is prevented, the oral micro-ecological balance is adjusted, the lactobacillus gasseri is a human native strain, the number of bacteria can be maintained to be small after long-term supplement, a mucous membrane reinforced immune system is further stimulated, bacterial and viral infection can be reduced, various types of allergic symptoms can be effectively changed, and the compound probiotic has a better comprehensive effect compared with a single strain, the antibacterial peptide is generated by probiotics, has competitive inhibition effect on other bacteria, can kill harmful flora, has strong inhibition effect on various periodontal pathogenic bacteria, relieves the oral odor, and is safe to use and free of side effect;
The probiotic oral bacteriostatic paste capable of recovering oral peculiar smell is added with a lactoferrin component, the lactoferrin can inhibit intestinal pathogenic bacteria, can organize the inner wall of the intestinal tract to absorb various pathogenic bacteria, can assist in treating inflammatory diseases caused by various bacterial infections, can prevent the pathogenic bacteria from invading and infecting the human body again, has good beneficial effect on human body, contains vitamin components capable of maintaining and protecting teeth and gum, and is added with orange peel powder, borneol and pseudo-ginseng, wherein the pericarpium Citri Tangerinae powder is prepared from fresh pericarpium Citri Tangerinae, contains vitamin C and essence components, and can effectively strengthen teeth, Borneolum has effects of clearing heat and detoxicating, Notoginseng radix has effects of relieving pain, removing blood stasis and stopping bleeding, and plant extract can promote gingival health, therefore, the oral bacteriostatic cream can be matched with breath freshening components to realize rehabilitation treatment of oral peculiar smell on the basis of treating oral diseases.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below with reference to specific embodiments of the present invention, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all of the embodiments.
A probiotic oral cavity bacteriostatic paste capable of recovering oral peculiar smell is prepared from the following raw materials in parts by weight:
30-45 parts of powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant, 1-8 parts of thickener, 2-6 parts of foaming agent, 1.5-2 parts of food-grade surfactant, 12-20 parts of plant extract, 3-10 parts of composite probiotics, 2-7 parts of lactoferrin, 0.5-2 parts of vitamin, 0.5-3 parts of antibacterial peptide, 0.2-3.5 parts of orange peel powder, 2-3 parts of borneol, 0.5-2.5 parts of pseudo-ginseng, 0.1-1 part of flavoring agent and the balance of deionized water;
the preparation process of the probiotic oral bacteriostatic paste capable of recovering oral peculiar smell comprises the following steps:
(1) preparing a plant extract;
(2) preparing the composite probiotics;
(3) preparing an antibacterial cream substrate;
(4) mixing the antibacterial paste;
(5) and filling the antibacterial paste into a warehouse.
The probiotic oral bacteriostatic cream capable of recovering the peculiar smell of the oral cavity comprises the following specific steps:
(1) preparation of plant extract
S1, primary leaching, namely, respectively cleaning lophatherum gracile, honeysuckle, radix zanthoxyli, pseudo-ginseng and mint with clear water to remove impurities, drying, crushing and sieving to obtain plant powder with a mesh of 50-120, adding purified water 6-8 times of the amount of the plant powder into primary leaching equipment, mixing the plant powder with the purified water, leaching, boiling for 5-10min during the leaching process, and keeping the temperature of 60-80 ℃ for continuous leaching for 60-90min to obtain primary leaching liquid;
S2 performing secondary leaching, feeding the residual filter residue into secondary leaching equipment, adding 3-5 times of purified water again, and leaching at 60-80 deg.C for 30-60min to obtain secondary leaching solution;
s3, mixing and concentrating, mixing the primary leaching liquor and the secondary leaching liquor to obtain mixed liquor, then carrying out centrifugal filtration on the mixed liquor by adopting a centrifugal machine to remove impurities, removing impurities in the mixed liquor, filtering and concentrating to obtain a plant extract;
the plant extract is a mixture of a lophatherum gracile extract, a honeysuckle extract, a zanthoxylum dissitum hemsl extract and a mint extract, and the proportion of the lophatherum gracile, the honeysuckle, the zanthoxylum dissitum hemsl, the pseudo-ginseng and the mint in the preparation process of the plant extract is 1:1:2:1: 2; the water content of the plant extract product is below 10%; in the preparation process of the plant extract in the step (1), when S1 primary leaching and S2 secondary leaching are carried out, primary leaching liquor equipment is connected with secondary leaching equipment, filter residues are obtained after primary operation and are simultaneously operated, then water vapor generated in the boiling process of the primary leaching is introduced into a water body of the secondary leaching, the cyclic leaching is carried out, and meanwhile, ultrasonic generators and transducer vibrators are arranged on the inner walls of the primary leaching liquor equipment and the secondary leaching equipment;
(2) Preparation of composite probiotics
Lactobacillus reuteri, Lactobacillus salivarius and Lactobacillus gasseri are mixed according to a ratio of 2: 1: 1, preparing a compound strain, namely compound probiotics;
(3) preparation of antibacterial cream base
Weighing 30-45 parts of powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant and 1.5-2 parts of food-grade surfactant according to the mass parts, adding the powdery abrasive into deionized water, heating and stirring to uniformly mix the powdery abrasive, the adhesive, the humectant and the food-grade surfactant, wherein the stirring temperature is 40-50 ℃, the stirring time is 45-80min, the stirring speed is 800-1500 rpm, fully mixing to obtain a toothpaste matrix, and performing high-temperature sterilization on the toothpaste matrix;
in the preparation process of the antibacterial paste matrix in the step (3), the sterilization temperature of the toothpaste matrix for high-temperature sterilization is 100-120 ℃, and the sterilization time is 15-25 min;
the probiotic oral bacteriostatic cream capable of recovering the peculiar smell of the oral cavity further comprises the following specific steps:
(4) and antibacterial cream mixed preparation
Weighing 12-20 parts of plant extract, 3-10 parts of composite probiotics, 2-7 parts of lactoferrin, 0.5-2 parts of vitamin, 0.5-3 parts of antibacterial peptide, 0.2-3.5 parts of orange peel powder, 2-3 parts of borneol and 0.5-2.5 parts of pseudo-ginseng according to parts by mass, fully mixing to obtain a pasty mixture, adding the pasty mixture into a toothpaste matrix after the temperature of the toothpaste matrix is reduced to normal temperature, adding 0.1-1 part of flavoring agent, 1-8 parts of thickening agent and 2-6 parts of foaming agent, fully mixing at the stirring temperature of 40-50 ℃ for 45-80min at the stirring speed of 1200-2200 rpm in the mixing process, and finally obtaining a mixed paste body;
In the process of mixing and preparing the antibacterial paste in the step (4), the tangerine peel powder, the borneol and the pseudo-ginseng are all in powder structures, and the particle size of the powder is 5-30 mu m; in the process of mixing and preparing the antibacterial cream in the step (4), the feeding of all raw materials in the stirring process specifically adopts an intermittent raw material feeding mode;
the probiotic oral bacteriostatic paste capable of recovering the oral peculiar smell also comprises the following specific steps:
(5) and checking the antibacterial cream product
And homogenizing the mixed paste by using a homogenizer to prepare an antibacterial paste body, inspecting the antibacterial paste body to ensure that the antibacterial paste body meets the quality standard, vacuumizing the antibacterial paste body with qualified quality after inspection, filling and sealing, randomly sampling and checking the batch number, the filling amount and the sealing condition, and finally boxing and warehousing and placing in a cool and ventilated place for low-temperature storage.
The first embodiment is as follows:
cleaning herba Lophatheri, flos Lonicerae, radix Zanthoxyli, Notoginseng radix, and herba Menthae with clear water respectively to remove impurities, air drying, pulverizing, and sieving with 80 mesh sieve to obtain plant powder, wherein the ratio of herba Lophatheri, flos Lonicerae, radix Zanthoxyli, Notoginseng radix, and herba Menthae is 1:1:2:1:2 in the preparation process of plant extract; adding 6-8 times of purified water into the primary leaching solution equipment, mixing with plant powder, leaching, boiling for 5-10min, and continuously leaching at 60-80 deg.C for 60-90min to obtain primary leaching solution; feeding the residual filter residue into secondary leaching equipment, adding 3-5 times of purified water again, and leaching at 60-80 deg.C for 30-60min to obtain secondary leaching solution; mixing the primary leaching solution and the secondary leaching solution to obtain a mixed solution, then carrying out centrifugal filtration on the mixed solution by adopting a centrifugal machine to remove impurities, removing impurities in the mixed solution, filtering and concentrating to obtain a plant extract, wherein the water content of a finished product of the plant extract is less than 10%; during primary leaching and secondary leaching, connecting primary leaching equipment with secondary leaching equipment, operating simultaneously after filter residue is obtained after primary operation, introducing steam generated during boiling of primary leaching into a water body of secondary leaching, and circularly leaching, wherein ultrasonic generators and transducer vibrators are arranged on the inner walls of the primary leaching equipment and the secondary leaching equipment; then, the lactobacillus reuteri, the lactobacillus salivarius and the lactobacillus gasseri are mixed according to the ratio of 2:1: 1, preparing a compound strain, namely compound probiotics;
Weighing 40 parts of powdery abrasive, 3 parts of adhesive, 15 parts of humectant and 2 parts of food-grade surfactant according to the mass parts, adding the materials into deionized water, heating and stirring to uniformly mix the materials, wherein the stirring temperature is 405 ℃, the stirring time is 460min, the stirring speed is 1200rpm, fully mixing to obtain toothpaste matrix, and carrying out high-temperature sterilization on the toothpaste matrix; sterilizing the toothpaste matrix at 120 deg.C for 18 min; weighing 120 parts of plant extract, 7 parts of composite probiotics, 3 parts of lactoferrin, 1 part of vitamin, 0.5 part of antibacterial peptide, 2 parts of orange peel powder, 2 parts of borneol and 2 parts of pseudo-ginseng according to the mass parts, and fully mixing to obtain a pasty mixture, wherein the orange peel powder, the borneol and the pseudo-ginseng are all in a powdery structure, and the particle size of the powder is 30 mu m; after the temperature of a toothpaste matrix is reduced to normal temperature, adding the pasty mixture into the toothpaste matrix, adding 1 part of flavoring agent, 3 parts of thickening agent and 3 parts of foaming agent, and fully mixing, wherein the stirring temperature is 45 ℃, the stirring time is 80min, the stirring speed is 2000rpm, and the feeding of each raw material in the stirring process specifically adopts an intermittent raw material feeding mode, so as to obtain a mixed paste; and homogenizing the mixed paste by using a homogenizer to prepare an antibacterial paste body, inspecting the antibacterial paste body to ensure that the antibacterial paste body meets the quality standard, vacuumizing the antibacterial paste body with qualified quality after inspection, filling and sealing, randomly sampling and checking the batch number, the filling amount and the sealing condition, and finally boxing and warehousing and placing in a cool and ventilated place for low-temperature storage.
In conclusion, the probiotic oral cavity bacteriostatic paste capable of recovering the oral cavity peculiar smell comprises the following specific steps of:
(1) and preparing a plant extract: cleaning herba Lophatheri, flos Lonicerae, radix Zanthoxyli, Notoginseng radix, and herba Menthae with clear water respectively to remove impurities, air drying, pulverizing, and sieving with 50-120 mesh sieve to obtain plant powder, wherein the ratio of herba Lophatheri, flos Lonicerae, radix Zanthoxyli, Notoginseng radix, and herba Menthae is 1:1:2:1: 2; adding 6-8 times of purified water into primary leaching solution equipment, mixing with plant powder, leaching, boiling for 5-10min during leaching, and maintaining at 60-80 deg.C for 60-90min to obtain primary leaching solution; feeding the residual filter residue into secondary leaching equipment, adding 3-5 times of purified water again, and leaching at 60-80 deg.C for 30-60min to obtain secondary leaching solution; mixing the primary leaching solution and the secondary leaching solution to obtain a mixed solution, then carrying out centrifugal filtration on the mixed solution by adopting a centrifugal machine to remove impurities in the mixed solution, and concentrating after filtration to obtain a plant extract, wherein the water content of a finished product of the plant extract is less than 10%; when S1 primary leaching and S2 secondary leaching are carried out, primary leaching equipment and secondary leaching equipment are connected, filter residue is obtained after primary operation and the operation is carried out simultaneously, then water vapor generated during boiling of the primary leaching is introduced into a water body of the secondary leaching, the circulation leaching is carried out, and an ultrasonic generator and an energy transducer vibrator are arranged on the inner walls of the primary leaching equipment and the secondary leaching equipment;
(2) And preparing the composite probiotics: lactobacillus reuteri, Lactobacillus salivarius and Lactobacillus gasseri are mixed according to a ratio of 2: 1: 1, preparing a composite strain, namely composite probiotics;
(3) preparing an antibacterial cream substrate: weighing 30-45 parts of powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant and 1.5-2 parts of food-grade surfactant according to the mass parts, adding the powdery abrasive into deionized water, heating and stirring to uniformly mix the powdery abrasive, the adhesive, the humectant and the food-grade surfactant, wherein the stirring temperature is 40-50 ℃, the stirring time is 45-80min, the stirring speed is 800-1500 rpm, fully mixing to obtain a toothpaste matrix, and performing high-temperature sterilization on the toothpaste matrix; the sterilization temperature of the toothpaste matrix is 100-120 ℃ when high-temperature sterilization is carried out, and the sterilization time is 15-25 min;
(4) and mixing the antibacterial paste: weighing 12-20 parts of plant extract, 3-10 parts of composite probiotics, 2-7 parts of lactoferrin, 0.5-2 parts of vitamin, 0.5-3 parts of antibacterial peptide, 0.2-3.5 parts of orange peel powder, 2-3 parts of borneol and 0.5-2.5 parts of pseudo-ginseng according to the mass parts, and fully mixing to obtain a pasty mixture, wherein the orange peel powder, the borneol and the pseudo-ginseng are all in a powdery structure, and the particle size of the powder is 5-30 mu m; after the temperature of a toothpaste matrix is reduced to normal temperature, adding the pasty mixture into the toothpaste matrix, adding 0.1-1 part of flavoring agent, 1-8 parts of thickening agent and 2-6 parts of foaming agent, and fully mixing, wherein the stirring temperature is 40-50 ℃ in the mixing process, the stirring time is 45-80min, the stirring speed is 1200-2200 rpm, and the feeding of all raw materials in the stirring process specifically adopts an intermittent raw material feeding mode, so that a mixed paste is finally obtained;
(5) And checking the antibacterial cream product: and homogenizing the mixed paste by using a homogenizer to prepare an antibacterial paste body, inspecting the antibacterial paste body to ensure that the antibacterial paste body meets the quality standard, vacuumizing the antibacterial paste body with qualified quality after inspection, filling and sealing, randomly sampling and checking the batch number, the filling amount and the sealing condition, and finally boxing and warehousing and placing in a cool and ventilated place for low-temperature storage.
The above description is only for the preferred embodiment of the present invention, but the scope of the present invention is not limited thereto, and any person skilled in the art should be able to cover the technical scope of the present invention and the equivalent alternatives or modifications according to the technical solution and the inventive concept of the present invention within the technical scope of the present invention.

Claims (10)

1. The probiotic oral bacteriostatic paste capable of recovering the peculiar smell in the oral cavity is characterized by comprising the following raw materials in parts by weight:
30-45 parts of powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant, 1-8 parts of thickener, 2-6 parts of foaming agent, 1.5-2 parts of food-grade surfactant, 12-20 parts of plant extract, 3-10 parts of composite probiotics, 2-7 parts of lactoferrin, 0.5-2 parts of vitamin, 0.5-3 parts of antibacterial peptide, 0.2-3.5 parts of orange peel powder, 2-3 parts of borneol, 0.5-2.5 parts of pseudo-ginseng, 0.1-1 part of flavoring agent and the balance of deionized water;
The preparation process of the probiotic oral bacteriostatic paste capable of recovering oral peculiar smell comprises the following steps:
(1) preparing a plant extract;
(2) preparing the composite probiotics;
(3) preparing an antibacterial cream substrate;
(4) mixing the antibacterial paste;
(5) and filling the antibacterial paste into a warehouse.
2. The probiotic oral bacteriostatic paste capable of recovering oral peculiar smell according to claim 1, which is characterized by comprising the following specific steps of:
(1) preparation of plant extract
S1, primary leaching, namely, respectively cleaning lophatherum gracile, honeysuckle, radix zanthoxyli, pseudo-ginseng and mint with clear water to remove impurities, drying, crushing and sieving to obtain plant powder with a mesh of 50-120, adding purified water 6-8 times of the amount of the plant powder into primary leaching equipment, mixing the plant powder with the purified water, leaching, boiling for 5-10min during the leaching process, and keeping the temperature of 60-80 ℃ for continuous leaching for 60-90min to obtain primary leaching liquid;
s2, secondary leaching, namely conveying the residual filter residue into secondary leaching equipment, then adding purified water in an amount which is 3-5 times that of the filter residue, and leaching for 30-60min at the temperature of 60-80 ℃ to obtain secondary leaching liquor;
s3, mixing and concentrating, mixing the primary leaching liquor and the secondary leaching liquor to obtain mixed liquor, then carrying out centrifugal filtration on the mixed liquor by adopting a centrifugal machine to remove impurities, removing impurities in the mixed liquor, filtering and concentrating to obtain a plant extract;
(2) Preparation of composite probiotics
Lactobacillus reuteri, Lactobacillus salivarius and Lactobacillus gasseri are mixed according to a ratio of 2: 1: 1, preparing a compound strain, namely compound probiotics;
(3) preparation of antibacterial cream base
Weighing 30-45 parts of powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant and 1.5-2 parts of food-grade surfactant according to the mass parts, adding the powdery abrasive, 1-5 parts of adhesive, 15-25 parts of humectant and 1.5-2 parts of food-grade surfactant into deionized water, heating and stirring to mix uniformly, wherein the stirring temperature is 40-50 ℃, the stirring time is 45-80min, the stirring speed is 800-1500 rpm, fully mixing to obtain toothpaste matrix, and performing high-temperature sterilization on the toothpaste matrix.
3. The probiotic oral bacteriostatic paste capable of recovering oral malodor according to claim 1, further comprising the following specific steps:
(4) and antibacterial cream mixed preparation
Weighing 12-20 parts of plant extract, 3-10 parts of composite probiotics, 2-7 parts of lactoferrin, 0.5-2 parts of vitamin, 0.5-3 parts of antibacterial peptide, 0.2-3.5 parts of orange peel powder, 2-3 parts of borneol and 0.5-2.5 parts of pseudo-ginseng according to parts by mass, fully mixing to form a pasty mixture, adding the pasty mixture into a toothpaste matrix after the temperature of the toothpaste matrix is reduced to normal temperature, adding 0.1-1 part of flavoring agent, 1-8 parts of thickening agent and 2-6 parts of foaming agent, fully mixing at the stirring temperature of 40-50 ℃ for 2200 min at the stirring speed of 1200-rpm, and finally obtaining the mixed paste.
4. The probiotic oral bacteriostatic paste capable of recovering oral peculiar smell according to claim 1, characterized in that the probiotic oral bacteriostatic paste capable of recovering oral peculiar smell further comprises the following specific steps:
(5) and checking the antibacterial cream product
And homogenizing the mixed paste by using a homogenizer to prepare an antibacterial paste body, inspecting the antibacterial paste body to ensure that the antibacterial paste body meets the quality standard, vacuumizing the antibacterial paste body with qualified quality after inspection, filling and sealing, randomly sampling and checking the batch number, the filling amount and the sealing condition, and finally boxing and warehousing and placing in a cool and ventilated place for low-temperature storage.
5. The probiotic oral bacteriostatic paste capable of recovering oral peculiar smell according to claim 2, characterized in that: the plant extract is a mixture of a lophatherum gracile extract, a honeysuckle extract, a zanthoxylum nitidum extract and a mint extract, and the proportion of the lophatherum gracile, the honeysuckle, the zanthoxylum nitidum, the pseudo-ginseng and the mint in the preparation process of the plant extract is 1:1:2:1: 2.
6. The probiotic oral bacteriostatic cream capable of recovering oral malodor according to claim 2, characterized in that: the water content of the finished product of the plant extract is below 10%.
7. The probiotic oral bacteriostatic cream capable of recovering oral malodor according to claim 2, characterized in that: in the preparation process of the plant extract in the step (1), when S1 primary leaching and S2 secondary leaching are carried out, primary leaching equipment and secondary leaching equipment are connected, filter residues are obtained after primary operation and are operated simultaneously, then steam generated in boiling of the primary leaching is introduced into a water body of the secondary leaching and is subjected to circulating leaching, and meanwhile, ultrasonic generators and transducer vibrators are arranged on the inner walls of the primary leaching equipment and the secondary leaching equipment.
8. The probiotic oral bacteriostatic cream capable of recovering oral malodor according to claim 2, characterized in that: in the preparation process of the antibacterial paste matrix in the step (3), the sterilization temperature of the toothpaste matrix for high-temperature sterilization is 100-120 ℃, and the sterilization time is 15-25 min.
9. The probiotic oral bacteriostatic cream capable of recovering oral malodor according to claim 2, characterized in that: in the mixing preparation process of the antibacterial paste in the step (4), the tangerine peel powder, the borneol and the pseudo-ginseng are all in powder structures, and the particle size of the powder is 5-30 mu m.
10. The probiotic oral bacteriostatic cream capable of recovering oral malodor according to claim 2, characterized in that: in the mixing preparation process of the antibacterial cream in the step (4), the feeding of the raw materials in the stirring process specifically adopts an intermittent raw material feeding mode.
CN202210177102.5A 2022-02-25 2022-02-25 Probiotic oral bacteriostatic paste capable of recovering oral peculiar smell Pending CN114668707A (en)

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Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106474011A (en) * 2016-12-09 2017-03-08 刘彩英 A kind of toothpaste and preparation method thereof
CN111820407A (en) * 2020-08-31 2020-10-27 北京同禧科技有限公司 Helicobacter pylori-resistant composition and application thereof

Patent Citations (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN106474011A (en) * 2016-12-09 2017-03-08 刘彩英 A kind of toothpaste and preparation method thereof
CN111820407A (en) * 2020-08-31 2020-10-27 北京同禧科技有限公司 Helicobacter pylori-resistant composition and application thereof

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