CN114652659B

CN114652659B - Moisturizing gel containing aloe and rose hydrosol

Info

Publication number: CN114652659B
Application number: CN202210508030.8A
Authority: CN
Inventors: 郑思斯
Original assignee: Guangzhou Landi Biotechnology Co ltd
Current assignee: Guangzhou Landi Biotechnology Co ltd
Priority date: 2022-05-10
Filing date: 2022-05-10
Publication date: 2023-07-14
Anticipated expiration: 2042-05-10
Also published as: CN114652659A

Abstract

The application provides a moisturizing gel containing aloe and rose hydrosol, which comprises aloe gel liquid, rose hydrosol, polygonatum polysaccharide, gel matrix and other preparation auxiliary materials. The invention solves the problem of skin dryness through aloe and rose hydrosol, and uses retinol to regulate the surface skin cells, reduces the generation of wrinkles, reduces melanin formation, improves skin color, adopts gamma-cyclodextrin and beta-cyclodextrin to clathrate the retinol, and adds linseed gum, thereby improving the stability of the retinol and reducing the problem of skin irritation.

Description

Moisturizing gel containing aloe and rose hydrosol

Technical Field

The invention relates to cosmetics, in particular to application of a moisturizing gel containing natural aloe and rose hydrosol in xerosis cutis and skin moisturizing.

Background

The skin has isolation and protection effects, and the skin is dark and dull, yellow, poor in skin elasticity and other skin aging bad symptoms formed by insufficient sleep due to work fatigue; skin aging phenomena such as skin relaxation, sagging, wrinkles, dryness, etc. due to age, solar radiation factors; because abnormal melanin in the body is secreted vigorously and is deposited on the surface of the skin in a large amount, the skin cannot metabolize abnormal melanin in time, and various color spots such as color spots, chloasma, freckle, early senile plaque and the like are formed; the skin is damaged due to improper maintenance of the skin during long-term outdoor activities, and adverse symptoms such as dry skin, desquamation, red swelling, large pores and the like occur prematurely. Due to endocrine dysfunction, the skin has poor skin quality, skin is oily and dark, and is easy to develop color marks, pigmentation and the like left by acne; due to irregular life, smoking and other factors, the problems of dark circles, eye bags and the like are caused; long-term work beside a computer, and the problem of alopecia and endocrine disturbance caused by computer radiation. Rough skin, xerosis is a group of symptoms of clinically common skin disorders, with dry stratum corneum, peeling, disordered skin texture, dry skin, and skin conditions covered with fine white debris, and other external features. Heavy persons cause chapping, bleeding and secondary infections. Also, chronic dry and rough skin is considered to be one of the main causes of skin aging promotion.

Aloe is an ancient plant, has great use value and economic value, and has long application history in Chinese medicine. Modern Chinese medicine research shows that aloe has very high cell penetrating capacity and hypoallergenic medicine effect, so that aloe gel is one natural penetrating agent for human skin, surface cell promoter and cell growth stimulator.

The rose hydrosol is also called as rose water essential oil, and is a 100% saturated distilled stock solution separated from rose when extracting essential oil, and the rose hydrosol is dissolved in water and has the functions of supplementing water, preserving moisture and the like.

Retinol also has regulating effect on the growth process of epidermal cells, can thicken skin, and has effect in relieving natural aging wrinkles; in addition, it can inhibit the enzyme of the complex amino acid, reduce melanin formation, and improve skin color. However, retinol is highly acidic and is too irritating to the skin. In addition, the class A has the disadvantages of poor stability and light sensitivity. Ultraviolet light, air, heat, water, and peroxidation all cause them to lose biological activity.

Disclosure of Invention

The invention aims to provide a moisturizing gel containing aloe and rose hydrosol, which has good moisturizing performance and small irritation.

The aloe and rose hydrosol are used for solving the problem of skin dryness, and retinol is used for regulating the surface skin cells, so that the generation of wrinkles is reduced, the melanin formation is reduced, the skin color is improved, and meanwhile, the technical means are adopted for improving the stability of retinol and reducing the problem of skin irritation.

In order to achieve the above purpose, the present invention adopts the following technical scheme:

a moisturizing gel containing aloe and flos Rosae Rugosae hydrosol comprises aloe gel solution, flos Rosae Rugosae hydrosol, rhizoma Polygonati polysaccharide, gel matrix, flavones and other adjuvants.

Further, the mass ratio of the aloe gel solution to the rose hydrosol is 1:1.

further, the gel matrix is carbomer.

Further, the gel matrix is carbomer 940.

Further, the composition comprises the following components in percentage by weight: 10-20% of aloe gel liquid, 10-20% of rose hydrosol, 5-10% of retinol, 0.5-0.8% of carbomer, 0.1-0.3% of triethanolamine, 0.1-0.2% of Kathon, 0.5-1.5% of glycerol and the balance of water.

Further, the composition comprises the following components in percentage by weight: 15% of aloe gel solution, 15% of rose hydrosol, 8% of retinol, 0.6% of carbomer, 0.2% of triethanolamine, 0.2% of Kathon, 1% of glycerol and the balance of water.

Further, the retinol is the retinol which is included by cyclodextrin, the cyclodextrin is gamma-cyclodextrin and beta-cyclodextrin with the weight ratio of 2:3, a thickening agent is used in the inclusion process, and the thickening agent is flaxseed gum.

Further, the weight ratio of retinol, gamma-cyclodextrin, beta-cyclodextrin and flaxseed gum used in the inclusion process is 1:2:3:0.3.

Furthermore, the rose hydrosol is prepared by a pressure extraction method.

The invention also discloses a preparation method of the moisturizing gel of aloe and rose hydrosol, which comprises the following steps:

(1) Preparation of cyclodextrin-coated retinol: adding 20 times of purified water into required retinol and flaxseed gum, heating to 70deg.C, stirring for 1 hr for dissolution; adding 60 times of purified water into cyclodextrin with the required amount, and performing ultrasonic treatment for 20 minutes to dissolve; mixing retinol and flaxseed gum solution with cyclodextrin solution, and stirring at 50deg.C for 2 hr; filtering to obtain clathrate retinol solution;

(2) Deionized water is added into a container, slightly heated to 30-40 ℃, carbomer is added, and the carbomer is continuously stirred until the carbomer is completely dissolved;

(3) Adding aloe gel solution, rose hydrosol and cyclodextrin inclusion retinol, stirring, adding glycerol, and stirring;

(3) Adding triethanolamine, stirring to thick, stopping heating, adding Kathon, stirring, and cooling to room temperature.

The invention solves the problem of skin dryness through aloe and rose hydrosol, and uses retinol to regulate the surface skin cells, reduces the generation of wrinkles, reduces melanin formation, improves skin color, adopts gamma-cyclodextrin and beta-cyclodextrin to clathrate the retinol, and adds linseed gum, thereby improving the stability of the retinol and reducing the problem of skin irritation.

Drawings

FIG. 1 is a graph showing the results of stability testing of formulations 1-4 under sealed conditions;

FIG. 2 is a graph showing the results of stability testing of formulations 1-4 under unsealed conditions;

FIG. 3 shows the results of stability testing of formulations 5-8 under unsealed conditions.

Detailed Description

Main reagent and experimental method

Aloe gel solution: king chemical Co., ltd. Of Guangzhou flower;

rose hydrosol: jining Hengkang biological medicine Co., ltd;

retinol: jiangsu New Biotech Co., ltd;

gamma-cyclodextrin, beta-cyclodextrin: anhui Qianshun biotechnology Co., ltd;

other reagents and instruments are all conventional domestic species meeting relevant standards.

Example 1: preparing a cyclodextrin inclusion retinol solution:

adding 10g of retinol and 3g of flaxseed gum into purified water with 20 times of mass, heating to 70 ℃ and stirring for dissolution; taking 20g of gamma-cyclodextrin and 30g of beta-cyclodextrin, adding 60 times of water, and performing ultrasonic treatment for 20 minutes to dissolve; mixing retinol solution and cyclodextrin solution, and stirring at 50deg.C for 2 hr; filtering to obtain clathrate retinol solution.

Example 2: preparing moisturizing gel containing aloe and rose hydrosol:

1000g of moisturizing gel is prepared by adopting the following formula:

150g of aloe gel solution, 150g of rose hydrosol and 80g of retinol coated by cyclodextrin

Carbomer 940 g glycerol 10g triethanolamine 2g

Kathon 2g balance deionized water

The preparation method comprises the following steps:

(1) Deionized water is added into a container, slightly heated to 30-40 ℃, carbomer is added, and the carbomer is continuously stirred until the carbomer is completely dissolved;

(2) Adding aloe gel solution, rose hydrosol and cyclodextrin inclusion retinol, stirring, adding glycerol, and stirring;

Example 3: safety test

1. Acute toxicity test of skin

20 rabbits (2.5+ -0.5 KG) were treated with the method for 28 days.

Results: the gel obtained in the embodiment 2 of the invention is applied to rabbit skin for 1.0-2.0 g daily for 28 continuous days, and no skin reaction or systemic toxic reaction exists, so that the gel of the invention is judged to not produce absorption toxic reaction.

2. Skin irritation test

20 rabbits were taken and manipulated according to conventional methods.

Results: according to the skin irritation test operation and evaluation of cosmetic health Specification, the mark of the gel group and the blank matrix group of the invention on the irritation response of rabbits is 0, so the gel is judged to be non-irritating.

Example 4: related experiments for cyclodextrin inclusion of retinol:

quantitative retinol detection method

Taking 50mg of retinol standard substance, dissolving in absolute ethanol, and then fixing the volume to 10mL, using the standard solution to prepare 0.5, 0.4, 0.3, 0.2, 0.1, 0.05, 0.03 and 0.01g/L retinol solution, measuring at 326nmThe light absorption (the absorption peak of retinol included by cyclodextrin is basically free from transformation and is near 325-326nm after the preliminary measurement) is fixed, and the regression equation is calculated as A= -0.0445+17.24p (p is the mass concentration, R) ² =0.997)。

Basic inclusion method of retinol

Adding 20 times of purified water into the required retinol and optional thickener, heating to 70 ℃ and stirring for 1 hour for dissolution; adding 60 times of cyclodextrin into water, and performing ultrasonic treatment for 20 minutes to dissolve; mixing the retinol (and optional thickener) solution with the cyclodextrin solution, stirring at 50 degrees celsius for 2 hours; filtering to obtain clathrate retinol solution.

Evaluation of stability of retinol solution

100mL of retinol or retinol clathrate solution (converted to retinol concentration 0.4 g/L) was placed in a transparent beaker; adding three layers of preservative films for sealing (the sealing films are opened for 1 hour every day when the simulated open preservation is carried out); placing under the fluorescent lamp illumination condition of room temperature and 500lux illuminance; the retinol content was measured at the desired time.

Different inclusion formulations

For ease of illustration and comparison, all formulations referred to in this application are listed in a single table, on the one hand, these formulations are merely representative formulations (some of the effective proportions or amounts have been selected) and a large number of groped conditions and formulations of ratios have not been illustrated; on the other hand, testing of these formulations is not done at once.

Table 1 inclusion formulations referred to in this application

Recipe numbering	Inclusion reagent
		1	Retinol 1 part (without inclusion treatment,as a control
2	1 part of retinol and 5 parts of beta-cyclodextrin
		3	Retinol 1 part, gamma-cyclodextrin 4 parts
4	1 part of retinol, 2 parts of gamma-cyclodextrin and 3 parts of beta-cyclodextrin
		5	1 part of retinol, 2 parts of gamma-cyclodextrin, 3 parts of beta-cyclodextrin and 0.3 part of flaxseed gum
6	1 part of retinol, 2 parts of gamma-cyclodextrin, 3 parts of beta-cyclodextrin and 0.3 part of guar gum
		9	1 part of retinol, 2 parts of gamma-cyclodextrin, 3 parts of beta-cyclodextrin and 0.3 part of xanthan gum
10	1 part of retinol, 2 parts of gamma-cyclodextrin, 3 parts of beta-cyclodextrin and 0.5 part of acacia

2. Testing of inclusion Properties of different Cyclodextrins

The inventors have tried to clathrate retinol with three different common cyclodextrins, and preliminary experiments have shown that α -cyclodextrin cannot exert a significant clathrating effect regardless of the proportions and conditions, which may be related to its spatial structure and size.

The separate use of gamma-cyclodextrin and beta-cyclodextrin with better space can improve the stability of retinol to a certain extent, and the combination effect of the two is better, especially the long-time sealed preservation effect, because the cyclodextrin inclusion is single-molecule inclusion, the cyclodextrin inclusion compound is presumed to be possibly related to a certain amount of gamma-cyclodextrin inclusion compound which can provide better solubility for proper amount of retinol so as to resist the influence of illumination in certain ways (the sealed preservation effect of the formulas 1-4 is shown in figure 1).

However, the results of formulas 1-4 under simulated open storage conditions were all not ideal (the open storage effect of formulas 1-4 is shown in FIG. 2), and although the storage performance of the inclusion compound is still significantly better than that of the non-inclusion product, the retinol content of all three formulas including the combination of gamma-cyclodextrin and beta-cyclodextrin was reduced to a level of less than 30% at 30 days. Considering that the conditions of sealing and light shielding after the product is actually unsealed and used are often not added, and the consumer sense of the essence product using the light shielding packaging bottle is obviously inferior to that of a light-colored or light-transmitting bottle. Formulation 4 still leaves room for further improvement.

3. Inclusion performance test of different thickeners

I have attempted to add thickeners to further improve the antioxidant and light stability of the retinol inclusion compound. The partial results are shown in FIG. 3.

Experimental results show that the effect of preserving retinol can be effectively improved by adding a small amount of thickener which does not form gel or viscous state into the inclusion compound, especially the effect of flaxseed gum is most prominent, and more than half of retinol is still preserved until 40 days after simulated open preservation. Under the condition of matching with proper package (certain light-shielding property under the condition of good appearance) and shorter opening time (the opening time per day in actual use is generally shorter than 1 hour under the simulated condition), the effect of the product after being unsealed for about 1 month can be completely ensured not to be obviously reduced.

Claims

1. A moisturizing gel containing aloe and rose hydrosol comprises aloe gel solution, rose hydrosol, rhizoma Polygonati polysaccharide, gel matrix, retinol and other adjuvants; the retinol is the retinol which is included by cyclodextrin, wherein the cyclodextrin is gamma-cyclodextrin and beta-cyclodextrin with the weight ratio of 2:3, a thickening agent is used in the inclusion process, and the thickening agent is flaxseed gum.

2. The moisturizing gel containing aloe vera and rose hydrosol according to claim 1, wherein the mass ratio of aloe vera gel to rose hydrosol is 1:1.

3. the moisturizing gel comprising aloe vera and rose hydrosol of claim 1, wherein the gel matrix is carbomer.

4. A moisturizing gel comprising aloe vera and rose hydrosol as claimed in claim 3, wherein the gel matrix is carbomer 940.

5. The moisturizing gel containing aloe vera and rose hydrosol as claimed in claim 1, characterized by comprising the following components in percentage by weight: 10-20% of aloe gel liquid, 10-20% of rose hydrosol, 5-10% of retinol, 3-5% of polygonatum polysaccharide, 0.5-0.8% of carbomer, 0.1-0.3% of triethanolamine, 0.1-0.2% of Kathon, 0.5-1.5% of glycerol and the balance of water.

6. The moisturizing gel containing aloe vera and rose hydrosol of claim 5, comprising the following components in weight percent: 15% of aloe gel solution, 15% of rose hydrosol, 8% of retinol, 4% of polygonatum polysaccharide, 0.6% of carbomer, 0.2% of triethanolamine, 0.2% of Kathon, 1% of glycerol and the balance of water.

7. The moisturizing gel containing aloe vera and rose hydrosol of claim 1, wherein the weight ratio of retinol, gamma-cyclodextrin, beta-cyclodextrin, flaxseed gum used in the inclusion process is 1:2:3:0.3.

8. The moisturizing gel containing aloe vera and rose hydrosol according to claim 1, wherein the rose hydrosol is prepared by a pressure extraction method.

9. The method for preparing the moisturizing gel of aloe vera and rose hydrosol according to any one of claims 1 to 8, characterized by comprising the steps of: