CN1146326C - Process for preparing feed nano additive to adsorb fungal toxin from feed - Google Patents
Process for preparing feed nano additive to adsorb fungal toxin from feed Download PDFInfo
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- CN1146326C CN1146326C CNB021110972A CN02111097A CN1146326C CN 1146326 C CN1146326 C CN 1146326C CN B021110972 A CNB021110972 A CN B021110972A CN 02111097 A CN02111097 A CN 02111097A CN 1146326 C CN1146326 C CN 1146326C
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- mycotoxin
- feed additive
- ore pulp
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- 239000002636 mycotoxin Substances 0.000 title claims abstract description 35
- 239000000654 additive Substances 0.000 title claims description 14
- 230000000996 additive effect Effects 0.000 title claims description 14
- 238000004519 manufacturing process Methods 0.000 title abstract description 5
- 231100000678 Mycotoxin Toxicity 0.000 claims abstract description 34
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims abstract description 17
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims abstract description 14
- 238000001179 sorption measurement Methods 0.000 claims abstract description 10
- 229920002581 Glucomannan Polymers 0.000 claims abstract description 8
- 239000002002 slurry Substances 0.000 claims abstract description 7
- 239000011780 sodium chloride Substances 0.000 claims abstract description 7
- 238000000034 method Methods 0.000 claims description 15
- 238000003756 stirring Methods 0.000 claims description 10
- GUJOJGAPFQRJSV-UHFFFAOYSA-N dialuminum;dioxosilane;oxygen(2-);hydrate Chemical compound O.[O-2].[O-2].[O-2].[Al+3].[Al+3].O=[Si]=O.O=[Si]=O.O=[Si]=O.O=[Si]=O GUJOJGAPFQRJSV-UHFFFAOYSA-N 0.000 claims description 8
- 238000006243 chemical reaction Methods 0.000 claims description 7
- 229910052901 montmorillonite Inorganic materials 0.000 claims description 7
- 229910052500 inorganic mineral Inorganic materials 0.000 claims description 6
- 239000011707 mineral Substances 0.000 claims description 6
- 229910002651 NO3 Inorganic materials 0.000 claims description 5
- NHNBFGGVMKEFGY-UHFFFAOYSA-N Nitrate Chemical compound [O-][N+]([O-])=O NHNBFGGVMKEFGY-UHFFFAOYSA-N 0.000 claims description 5
- 239000002244 precipitate Substances 0.000 claims description 5
- 239000000725 suspension Substances 0.000 claims description 5
- 230000018044 dehydration Effects 0.000 claims description 4
- 238000006297 dehydration reaction Methods 0.000 claims description 4
- 238000010298 pulverizing process Methods 0.000 claims description 4
- 238000001291 vacuum drying Methods 0.000 claims description 4
- MBMQEIFVQACCCH-XVNBXDOJSA-N (S,E)-Zearalenone Chemical compound O=C1OC(C)CCCC(=O)CCC\C=C\C2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-XVNBXDOJSA-N 0.000 abstract description 7
- 241001465754 Metazoa Species 0.000 abstract description 7
- BXFOFFBJRFZBQZ-QYWOHJEZSA-N T-2 toxin Chemical compound C([C@@]12[C@]3(C)[C@H](OC(C)=O)[C@@H](O)[C@H]1O[C@H]1[C@]3(COC(C)=O)C[C@@H](C(=C1)C)OC(=O)CC(C)C)O2 BXFOFFBJRFZBQZ-QYWOHJEZSA-N 0.000 abstract description 7
- 229930183344 ochratoxin Natural products 0.000 abstract description 7
- MBMQEIFVQACCCH-UHFFFAOYSA-N trans-Zearalenon Natural products O=C1OC(C)CCCC(=O)CCCC=CC2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-UHFFFAOYSA-N 0.000 abstract description 6
- MBMQEIFVQACCCH-QBODLPLBSA-N zearalenone Chemical compound O=C1O[C@@H](C)CCCC(=O)CCC\C=C\C2=CC(O)=CC(O)=C21 MBMQEIFVQACCCH-QBODLPLBSA-N 0.000 abstract description 6
- 229930195730 Aflatoxin Natural products 0.000 abstract description 5
- XWIYFDMXXLINPU-UHFFFAOYSA-N Aflatoxin G Chemical compound O=C1OCCC2=C1C(=O)OC1=C2C(OC)=CC2=C1C1C=COC1O2 XWIYFDMXXLINPU-UHFFFAOYSA-N 0.000 abstract description 5
- 239000005409 aflatoxin Substances 0.000 abstract description 5
- 238000002360 preparation method Methods 0.000 abstract description 4
- 239000003674 animal food additive Substances 0.000 abstract 6
- 229910021647 smectite Inorganic materials 0.000 abstract 2
- LUEWUZLMQUOBSB-FSKGGBMCSA-N (2s,3s,4s,5s,6r)-2-[(2r,3s,4r,5r,6s)-6-[(2r,3s,4r,5s,6s)-4,5-dihydroxy-2-(hydroxymethyl)-6-[(2r,4r,5s,6r)-4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxan-3-yl]oxy-4,5-dihydroxy-2-(hydroxymethyl)oxan-3-yl]oxy-6-(hydroxymethyl)oxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1O[C@@H]1[C@@H](CO)O[C@@H](O[C@@H]2[C@H](O[C@@H](OC3[C@H](O[C@@H](O)[C@@H](O)[C@H]3O)CO)[C@@H](O)[C@H]2O)CO)[C@H](O)[C@H]1O LUEWUZLMQUOBSB-FSKGGBMCSA-N 0.000 abstract 1
- 241000272496 Galliformes Species 0.000 abstract 1
- 238000001914 filtration Methods 0.000 abstract 1
- 229940046240 glucomannan Drugs 0.000 abstract 1
- 230000036737 immune function Effects 0.000 abstract 1
- 230000000968 intestinal effect Effects 0.000 abstract 1
- 239000000203 mixture Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 description 9
- 230000009422 growth inhibiting effect Effects 0.000 description 9
- 244000144972 livestock Species 0.000 description 7
- 244000144977 poultry Species 0.000 description 6
- 239000000243 solution Substances 0.000 description 5
- 238000010521 absorption reaction Methods 0.000 description 4
- 208000010359 Newcastle Disease Diseases 0.000 description 3
- 238000011953 bioanalysis Methods 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000011067 equilibration Methods 0.000 description 3
- 239000000126 substance Substances 0.000 description 3
- QGZKDVFQNNGYKY-UHFFFAOYSA-N Ammonia Chemical compound N QGZKDVFQNNGYKY-UHFFFAOYSA-N 0.000 description 2
- 239000003463 adsorbent Substances 0.000 description 2
- 238000001784 detoxification Methods 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 239000002245 particle Substances 0.000 description 2
- 239000000047 product Substances 0.000 description 2
- 238000001228 spectrum Methods 0.000 description 2
- 239000005995 Aluminium silicate Substances 0.000 description 1
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 description 1
- 206010010774 Constipation Diseases 0.000 description 1
- 102000004190 Enzymes Human genes 0.000 description 1
- 108090000790 Enzymes Proteins 0.000 description 1
- 240000004859 Gamochaeta purpurea Species 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- 206010067482 No adverse event Diseases 0.000 description 1
- CBENFWSGALASAD-UHFFFAOYSA-N Ozone Chemical compound [O-][O+]=O CBENFWSGALASAD-UHFFFAOYSA-N 0.000 description 1
- ZMTYENXGROJCEA-LNKPQSDASA-N Vomicine Chemical compound O1CC=C([C@@H]2CC3=O)CN(C)CC[C@]43C(C=CC=C3O)=C3N3C(=O)C[C@H]1[C@H]2[C@H]34 ZMTYENXGROJCEA-LNKPQSDASA-N 0.000 description 1
- WKECTJXZMZMDBI-UHFFFAOYSA-N Vomicine Natural products Oc1cccc2c1N3C4C5C(CC3=O)OCC=C6CNCCC24C(=O)CC56 WKECTJXZMZMDBI-UHFFFAOYSA-N 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 239000003513 alkali Substances 0.000 description 1
- PZZYQPZGQPZBDN-UHFFFAOYSA-N aluminium silicate Chemical compound O=[Al]O[Si](=O)O[Al]=O PZZYQPZGQPZBDN-UHFFFAOYSA-N 0.000 description 1
- 229910000323 aluminium silicate Inorganic materials 0.000 description 1
- 235000012211 aluminium silicate Nutrition 0.000 description 1
- 229910021529 ammonia Inorganic materials 0.000 description 1
- 230000036528 appetite Effects 0.000 description 1
- 235000019789 appetite Nutrition 0.000 description 1
- 238000009360 aquaculture Methods 0.000 description 1
- 244000144974 aquaculture Species 0.000 description 1
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 1
- 229910052799 carbon Inorganic materials 0.000 description 1
- 235000013339 cereals Nutrition 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 230000007423 decrease Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 239000012895 dilution Substances 0.000 description 1
- 238000010790 dilution Methods 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical compound O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 230000008030 elimination Effects 0.000 description 1
- 238000003379 elimination reaction Methods 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 235000021050 feed intake Nutrition 0.000 description 1
- 235000013305 food Nutrition 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000008187 granular material Substances 0.000 description 1
- 238000010438 heat treatment Methods 0.000 description 1
- 238000007654 immersion Methods 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 201000007270 liver cancer Diseases 0.000 description 1
- 208000014018 liver neoplasm Diseases 0.000 description 1
- 229920002521 macromolecule Polymers 0.000 description 1
- 125000000311 mannosyl group Chemical group C1([C@@H](O)[C@@H](O)[C@H](O)[C@H](O1)CO)* 0.000 description 1
- 244000005700 microbiome Species 0.000 description 1
- 238000005065 mining Methods 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 230000003647 oxidation Effects 0.000 description 1
- 238000007254 oxidation reaction Methods 0.000 description 1
- 235000019629 palatability Nutrition 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 239000002574 poison Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000002265 prevention Effects 0.000 description 1
- 230000005855 radiation Effects 0.000 description 1
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 1
- 239000002594 sorbent Substances 0.000 description 1
- 238000001694 spray drying Methods 0.000 description 1
- 238000010025 steaming Methods 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 230000009466 transformation Effects 0.000 description 1
- 230000001228 trophic effect Effects 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/28—Silicates, e.g. perlites, zeolites or bentonites
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/10—Organic substances
- A23K20/163—Sugars; Polysaccharides
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
- A23K20/22—Compounds of alkali metals
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Polymers & Plastics (AREA)
- Animal Husbandry (AREA)
- Zoology (AREA)
- Engineering & Computer Science (AREA)
- Food Science & Technology (AREA)
- Inorganic Chemistry (AREA)
- Fodder In General (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
Abstract
The present invention discloses a preparation method for a nanometer feed additive for absorbing mycotoxin in feed, which comprises the following steps: 1, nanometer smectite and sodium chloride are uniformly mixed by water according to the weight ratio: 1:0.1 to 0.2 to be made into ore slurry; then the residual nanometer smectite and sodium chloride are washed to be made into ore slurry; 2, the ore slurry is added to glucomannan under high-speed mixing to be mixed to react, and then the mixture is aged, washed and dehydrated; 3, filtration residues are dried and crushed. The nanometer feed additive provided by the present invention can absorb mycotoxin in broad spectrum, such as aflatoxin, zearalenone, ochratoxin, T-2 toxin and fusarium toxin. The nanometer feed additive has big surface area, high adsorption capacity, does not influenced by the pH value of intestinal canals and can be widely used within wide pH ranges. The addition level is small; the addition level of the nanometer feed additive is from 0.02% to 0.2% in the feed; the nanometer feed additive has no residues in animal bodies; the immune function of fowls can be reinforced, the production performance is enhanced, and the egg production is improved after the feed additive is used.
Description
Technical field
The present invention relates to the preparing nanometer feedstuff additive of mycotoxin in a kind of adsorption feed.
Background technology
According to statistics, 25% of the cereal total amount infected in the world by mycotoxin.Common mycotoxin has aflatoxin, zearalenone, ochratoxin, T-2 toxin, fusarium toxin, FT, vomicine, ergotin etc.Mycotoxin the lighter reduces the decline of livestock and poultry feed intake, undergrowth, feed efficiency in the feed, and weight person causes growth of animal to be obstructed, to poison or be dead, causes bigger economic loss; Even more serious is that the mycotoxin that remains in the livestock products can pass through food chain harm humans health.Epidemiological studies shows that aflatoxin is one of important cause of disease of human liver cancer.Therefore, the harm of elimination mycotoxin is that the significant problem of being badly in need of solution is produced in animal husbandry.
Treatment measures to the feed that is subjected to mycotoxin contamination mainly contain physics method, chemical method, bioanalysis and absorption method.The physics method has heating, selects, washes and methods such as immersion, radiation; Chemical method has methods such as ammonia cure steaming, ozone oxidation, clorox processing and alkali treatment; Bioanalysis mainly is a transformation of utilizing microorganism or enzyme, makes the mycotoxin detoxifcation or changes into hypotoxic material; The absorption rule is by adding the adsorbent prevention and reducing livestock and poultry and take in mycotoxin in daily ration.Physics method, chemical method, bioanalysis all have certain detoxification effect, but there are shortcomings such as nutrient in time-consuming, secondary pollution, the destruction feed and detoxification be not thorough, more or less there is deficiency aspect security, economy and the validity, is being difficult to actual applying in feed and aquaculture on a large scale; And absorption method is because it is safe and convenient to use, and livestock and poultry are had no adverse effects and are subjected to the attention of academia and industrial circle.
At present, be everlasting and add absorbing mycotoxins such as natural zeolite, active carbon in the mixed feed, additive capacity generally needs higher, yet this type of material consumption is excessive, not only reduce the trophic level of mixed feed, make coarse ash content overproof in the feed, and make feed palatability variation, make livestock and poultry poor appetite occur, phenomenons such as constipation influence the livestock and poultry normal growth.What is more important, the scope of common adsorbents adsorb mycotoxin is narrow and small, though effective adsorption of aflatoxin, still, the effect of its anti-zearalenone, ochratoxin, T-2 toxin, fusarium toxin is very limited.Therefore must research and develop mold toxin sorbent efficient, wide spectrum.Montmorillonite is a kind of natural nano level aluminium silicate mineral of dioctahedron layer structure, and in China part mining area, the higher nano montmorillonite of purity has formed millions of tonnes large ore deposit.Because particle size is little, has huge specific area, and surperficial shared percentage by volume is big, the key attitude on surface is different with granule interior with electronic state, the surface atom coordination is not congruent, and the activity site of particle surface is increased greatly, has produced the absorption of unconventional surface.Glucomannans is the macromolecule polysaccharide that glucose and mannose residue connect by β-1,4 glycosidic bond, and the present invention is by the modified montmorillonite used feed nano additive that makes absorbing mycotoxin of glucomannans.
Summary of the invention
The purpose of this invention is to provide the preparing nanometer feedstuff additive of mycotoxin in a kind of adsorption feed, it comprises the following steps:
1) be nano montmorillonite by weight: sodium chloride is 1: 0.1～0.2 ratio, adds water to stir, and makes the suspension ore pulp of concentration 20%～30%, washes 5～7 times to there not being Cl
-, detecting no white precipitate with the 0.1mol/L nitrate solution, water is made the ore pulp of concentration 5%～10% again;
2) in above-mentioned ore pulp, adding the glucomannans that is equivalent to mineral weight 5%～10% under the high-speed stirred, continuous stirring reaction 5～15 hours, reaction temperature is 60 ℃ ~ 85 ℃, wears out 2～4 days down at 30 ℃ ~ 50 ℃ then, wash 5～7 times, filter or centrifugal dehydration;
3) filter residue is used the airslide disintegrating mill dry pulverization process being lower than 80 ℃ of following vacuum drying, or filter residue to add the slurry that water makes again spray-dried to water content＜10%.
The consumption of the feed nano additive of absorbing mycotoxin of the present invention in feed is: according to feed gross weight meter, addition is 0.02～0.2%; Adding method is: with the product of ultra-micro powder shape with an amount of carrier, as adding in the feed again after the dilutions such as fine bran, corncob.
But feed addictive wide spectrum absorbing mycotoxin provided by the invention is as aflatoxin, zearalenone, ochratoxin, T-2 toxin and fusarium toxin; Surface area is big, high adsorption capacity; Be not subjected to the influence of enteron aisle pH, can acting under the pH scope widely; Addition is little, and the addition in feed is 0.02～0.2%; Noresidue in animal body; Use the immunity function that can strengthen livestock and poultry behind this feed addictive, improve production performance, improve egg production.
The specific embodiment
The present invention is further described in conjunction with following example.
Embodiment 1
1) be nano montmorillonite by weight: sodium chloride is 1: 0.1 ratio, adds water to stir, and makes the suspension ore pulp of concentration 20%, washes 5～7 times to there not being Cl
-, detecting no white precipitate with the 0.1mol/L nitrate solution, water is made the ore pulp of concentration 5% again;
2) in add the glucomannans that is equivalent to mineral weight 10% under the high-speed stirred in above-mentioned ore pulp, continuous stirring was reacted 15 hours, and reaction temperature is 85 ℃, wears out 2 days down at 50 ℃ then, washes centrifugal dehydration 5 times;
3) filter residue is used the airslide disintegrating mill dry pulverization process being lower than 80 ℃ of following vacuum drying.
4) press the feed nano additive of above-mentioned preparation to AFB
1, B
2, G
1, G
2, zearalenone, ochratoxin, T-2 toxin and fusarium toxin external adsorption rate reach 98%, 95%, 95%, 95%, 80%, 70%, 65% and 60% respectively, equilibration time is less than 20min, be not subjected to the influence of pH, can acting under the pH scope widely.The action effect that adsorbs in the mycotoxin body is seen Table 1.
Adsorb in the body of table 1 feed nano additive to mycotoxin
| Animal | Addition (%) | Observing effect |
| Fryer | 0.05 | Make the growth inhibitory effect of mycotoxin reduce 67～120% |
| Laying hen | 0.12 | Laying rate improves 5～46%, and the immune titre of newcastle disease improves 34～82%. |
| Piglet | 0.10 | Make the growth inhibitory effect of mycotoxin reduce 34～94% |
| The growth pig | 0.02 | Make the growth inhibitory effect of mycotoxin reduce 21～62% |
Embodiment 2
1) be nano montmorillonite by weight: sodium chloride is 1: 0.2 ratio, adds water to stir, and makes the suspension ore pulp of concentration 30%, washes 5～7 times to there not being Cl
-, detecting no white precipitate with the 0.1mol/L nitrate solution, water is made the ore pulp of concentration 10% again;
2) in add the glucomannans that is equivalent to mineral weight 5% under the high-speed stirred in above-mentioned ore pulp, continuous stirring was reacted 15 hours, and reaction temperature is 60 ℃, wears out 4 days down at 30 ℃ then, washes 5 times, and water is made slurry again;
3) the slurry spray-drying is to water content＜10%.
4) press the feed nano additive of above-mentioned preparation to AFB
1, B
2, G
1, G
2, zearalenone, ochratoxin, T-2 toxin and fusarium toxin external adsorption rate reach 95%, 90%, 89%, 92%, 75%, 70%, 64% and 60% respectively, equilibration time is less than 20min, be not subjected to the influence of pH, can acting under the pH scope widely.The action effect that adsorbs in the mycotoxin body is seen Table 2.
Adsorb in the body of table 2 feed nano additive to mycotoxin
| Animal | Addition (%) | Observing effect |
| Fryer | 0.15 | Make the growth inhibitory effect of mycotoxin reduce 72～104% |
| Laying hen | 0.20 | Laying rate improves 4～35%, and the immune titre of newcastle disease improves 27～63%. |
| Piglet | 0.20 | Make the growth inhibitory effect of mycotoxin reduce 24～76% |
| The growth pig | 0.05 | Make the growth inhibitory effect of mycotoxin reduce 35～77% |
Embodiment 3
1) be nano montmorillonite by weight: sodium chloride is 1: 0.15 ratio, adds water to stir, and makes the suspension ore pulp of concentration 20%, washes 5～7 times to there not being Cl
-, detecting no white precipitate with the 0.1mol/L nitrate solution, water is made the ore pulp of concentration 8% again;
2) in add the glucomannans that is equivalent to mineral weight 7% under the high-speed stirred in above-mentioned ore pulp, continuous stirring was reacted 5 hours, and reaction temperature is 85 ℃, wears out 3 days down at 50 ℃ then, washes centrifugal dehydration 5 times;
3) filter residue is used the airslide disintegrating mill dry pulverization process being lower than 80 ℃ of following vacuum drying.
4) press the feed nano additive of above-mentioned preparation to AFB
1, B
2, G
1, G
2, zearalenone, ochratoxin, T-2 toxin and fusarium toxin external adsorption rate reach 99%, 94%, 96%, 97%, 81%, 75%, 60% and 70% respectively, equilibration time is less than 20min, be not subjected to the influence of pH, can acting under the pH scope widely.The action effect that adsorbs in the mycotoxin body is seen Table 3.
Adsorb in the body of table 3 feed nano additive to mycotoxin
| Animal | Addition (%) | Observing effect |
| Fryer | 0.10 | Make the growth inhibitory effect of mycotoxin reduce 70～115% |
| Laying hen | 0.15 | Laying rate improves 10～30%, and the immune titre of newcastle disease improves 40～90%. |
| Piglet | 0.10 | Make the growth inhibitory effect of mycotoxin reduce 30～80% |
| The growth pig | 0.05 | Make the growth inhibitory effect of mycotoxin reduce 30～70% |
Claims (1)
1. the preparing nanometer feedstuff additive of mycotoxin in the adsorption feed is characterized in that its step is as follows:
1) be nano montmorillonite by weight: sodium chloride is 1: 0.1～0.2 ratio, adds water to stir, and makes the suspension ore pulp of concentration 20%～30%, washes 5～7 times to there not being Cl
-, detecting no white precipitate with the 0.1mol/L nitrate solution, water is made the ore pulp of concentration 5%～10% again;
2) in above-mentioned ore pulp, adding the glucomannans that is equivalent to mineral weight 5%～10% under the high-speed stirred, continuous stirring reaction 5～15 hours, reaction temperature is 60 ℃ ~ 85 ℃, wears out 2～4 days down at 30 ℃ ~ 50 ℃ then, wash 5～7 times, filter or centrifugal dehydration;
3) filter residue is used the airslide disintegrating mill dry pulverization process being lower than 80 ℃ of following vacuum drying, or filter residue to add the slurry that water makes again spray-dried to water content＜10%.
Priority Applications (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021110972A CN1146326C (en) | 2002-03-18 | 2002-03-18 | Process for preparing feed nano additive to adsorb fungal toxin from feed |
| PCT/CN2002/000537 WO2003077673A1 (en) | 2002-03-18 | 2002-08-05 | A process for producing a feed additive adsorbing the mycotoxin in the animal feed |
| AU2002323826A AU2002323826A1 (en) | 2002-03-18 | 2002-08-05 | A process for producing a feed additive adsorbing the mycotoxin in the animal feed |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CNB021110972A CN1146326C (en) | 2002-03-18 | 2002-03-18 | Process for preparing feed nano additive to adsorb fungal toxin from feed |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN1372814A CN1372814A (en) | 2002-10-09 |
| CN1146326C true CN1146326C (en) | 2004-04-21 |
Family
ID=4741393
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CNB021110972A Expired - Fee Related CN1146326C (en) | 2002-03-18 | 2002-03-18 | Process for preparing feed nano additive to adsorb fungal toxin from feed |
Country Status (3)
| Country | Link |
|---|---|
| CN (1) | CN1146326C (en) |
| AU (1) | AU2002323826A1 (en) |
| WO (1) | WO2003077673A1 (en) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN100349580C (en) * | 2004-08-02 | 2007-11-21 | 孙安权 | Mould catching agent and medicinal/health caring use |
| CN1295511C (en) * | 2005-01-26 | 2007-01-17 | 上海大学 | Detection for zearalenone |
| CN101361524B (en) * | 2007-08-10 | 2011-12-07 | 安琪酵母股份有限公司 | Biotoxin adsorbent and production method thereof |
| US8318475B2 (en) | 2009-01-14 | 2012-11-27 | Alltech, Inc. | Clay interlaced yeast compositions and methods of utilizing the same |
| KR101389240B1 (en) * | 2009-01-14 | 2014-04-24 | 올텍 법인회사 | Clay Interlaced Yeast compositions and methods of utilizing the same |
| CN102178130B (en) * | 2011-04-15 | 2013-04-17 | 中国农业科学院北京畜牧兽医研究所 | Mineral composite capable of removing mycotoxin as well as preparation method and application thereof |
| CN102488076B (en) * | 2011-11-07 | 2013-04-03 | 朝阳圣丰牧业有限公司 | Safe and efficient composite mildew preventive for feed |
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| CN103521181B (en) * | 2013-10-10 | 2015-04-15 | 浙江丰虹新材料股份有限公司 | Composite type mycotoxin adsorbent and preparation method thereof |
| CN104522755B (en) * | 2014-12-29 | 2017-11-17 | 晨光生物科技集团股份有限公司 | The removing process of aflatoxin in a kind of cottonseed |
| CN104783021B (en) * | 2015-04-15 | 2018-05-25 | 甘肃农业大学 | The method that T-2 toxin is removed using cyclodextrin as adsorbent |
| CN107788332B (en) * | 2016-08-31 | 2021-05-04 | 安琪酵母股份有限公司 | Probiotic high-efficiency toxin adsorbent and production method and application thereof |
| CN106902782A (en) * | 2017-03-10 | 2017-06-30 | 黄山学院 | One kind is for aflatoxin degradation adsorbent and preparation method thereof |
| CN107319267A (en) * | 2017-07-01 | 2017-11-07 | 河北工业大学 | A kind of mycotoxin takes off mould dose and preparation method thereof |
| CN107519843A (en) * | 2017-09-01 | 2017-12-29 | 华中农业大学 | Toxin compound adsorbents of animal and fowl fodder T 2 and its preparation method and application |
| CN107913679B (en) * | 2017-11-15 | 2020-09-15 | 中国科学院兰州化学物理研究所盱眙凹土应用技术研发中心 | Preparation method of esterified glucomannan/activated carbon/attapulgite composite mycotoxin adsorbent |
| CN110508258A (en) * | 2019-08-27 | 2019-11-29 | 华中农业大学 | It is a kind of to alleviate the compound adsorbent of animal heavy metal poisoning, preparation method and applications |
| CN111602630A (en) * | 2020-06-24 | 2020-09-01 | 山西农业大学 | Method for establishing broiler chicken small intestine mechanical injury model caused by vomitoxin |
| CN111961623B (en) * | 2020-08-25 | 2022-06-28 | 青岛农业大学 | Compound lactobacillus preparation and application thereof, compound mildew removing agent and application thereof |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5165946A (en) * | 1990-03-07 | 1992-11-24 | Engelhard Corporation | Animal feed additive and method for inactivating mycotoxins present in animal feeds |
| CN1027419C (en) * | 1990-08-08 | 1995-01-18 | 李久成 | Producting method for mineralizing agent of active mineral food |
-
2002
- 2002-03-18 CN CNB021110972A patent/CN1146326C/en not_active Expired - Fee Related
- 2002-08-05 WO PCT/CN2002/000537 patent/WO2003077673A1/en not_active Application Discontinuation
- 2002-08-05 AU AU2002323826A patent/AU2002323826A1/en not_active Abandoned
Also Published As
| Publication number | Publication date |
|---|---|
| WO2003077673A1 (en) | 2003-09-25 |
| CN1372814A (en) | 2002-10-09 |
| AU2002323826A1 (en) | 2003-09-29 |
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