CN114632117A

CN114632117A - Traditional Chinese medicine composition for treating gastric cancer, cholangiocarcinoma or liver cancer

Info

Publication number: CN114632117A
Application number: CN202210295533.1A
Authority: CN
Inventors: 黄传贵
Original assignee: Tonghe Life And Health Technology Jinhua Co ltd
Current assignee: Tonghe Life And Health Technology Jinhua Co ltd
Priority date: 2022-03-23
Filing date: 2022-03-23
Publication date: 2022-06-17

Abstract

The invention relates to a traditional Chinese medicine composition for treating gastric cancer, cholangiocarcinoma or liver cancer. The traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 450 portions of rhizoma cyperi 350-. The Chinese medicinal composition has the effects of regulating qi-flowing, relieving pain, clearing heat and resolving hard mass, has good treatment effect on gastric cancer, cholangiocarcinoma or liver cancer, and is not easy to relapse.

Description

Traditional Chinese medicine composition for treating gastric cancer, cholangiocarcinoma or liver cancer

Technical Field

The invention relates to the field of traditional Chinese medicines, in particular to a traditional Chinese medicine composition for treating gastric cancer, cholangiocarcinoma or liver cancer.

Background

Gastric Cancer (GC) is a malignant tumor originated from Gastric mucosal epithelium, and is not easy to diagnose in early stage, and most of Gastric cancers are diagnosed in late stage, so that the treatment effect is not satisfactory, and the GC has the characteristics of high recurrence rate and poor prognosis. In the late stage, pain, vomiting, hematemesis, and dark stool may also occur, as well as abdominal mass, epigastric tenderness, splenomegaly, jaundice, distant lymph node metastasis, pelvic metastasis, and other signs.

The traditional Chinese medicine considers that the stomach cancer belongs to the categories of 'prostration', 'accumulation', 'choke', 'stomach regurgitation' and the like, and is mainly formed by improper diet, dysfunction of spleen in transportation, endogenous phlegm dampness or emotional internal injury, unsmooth qi movement and phlegm-qi stasis and condensation.

Cholangiocarcinoma (CCA) is a malignant tumor derived from the biliary epithelium, and is classified into intrahepatic and extrahepatic cholangiocarcinomas according to the anatomical location of the tumor. As with many cancers, the risk of bile duct cancer increases with age, mostly concentrated between 50 and 70 years of age, and the difference in bile duct cancer prevalence between men and women may be due to a higher prevalence in men than in women due to primary sclerosing cholangitis. The symptoms of cholangiocarcinoma patients mainly include jaundice, light stool, deep yellow urine and skin pruritus, and are usually accompanied by systemic manifestations such as fatigue and weight loss, and cholangitis is often suggested by abdominal pain and fever.

According to traditional Chinese medicine, the bile duct cancer belongs to the categories of jaundice, accumulation and the like, and the pathogenesis of the bile duct cancer is similar to that of gallbladder cancer. In the early stage, emotional depression and liver and gallbladder qi stagnation occur; in the middle stage, incoordination between the spleen and stomach, retention of damp-heat in the interior, or even heat-toxicity is caused; in the late stage, the spleen and stomach are damaged, leading to the syndrome of invasion of vital qi by deficiency and pathogen.

Liver cancer is a common malignant tumor of the digestive system, and primary liver cancer comprises hepatocellular carcinoma and intrahepatic cholangiocellular carcinoma. Hepatocellular carcinoma is derived from hepatocytes and intrahepatic cholangiocellular carcinoma is derived from intrahepatic bile ducts. Globally, hepatocellular carcinoma accounts for about 75% of all liver cancers, and intrahepatic cholangiocellular carcinoma accounts for about 15%.

The traditional Chinese medicine considers that liver cancer belongs to the categories of 'accumulation', 'abdominal mass', 'jaundice', 'tympanites' and 'costalgia' in the traditional Chinese medicine, and the liver cancer is caused by the internal deficiency of vital qi, the invasion or the generation of pathogenic toxin, which leads to the dysfunction of viscera, and the mutual combination of phlegm, stasis, dampness, toxin and the like.

The present disclosure has been completed based on the above-mentioned knowledge.

Disclosure of Invention

The first purpose of the invention is to provide a traditional Chinese medicine composition which can be used for treating gastric cancer, cholangiocarcinoma or liver cancer, is safe and is not easy to relapse.

The second purpose of the invention is to provide the application of the traditional Chinese medicine composition.

The third purpose of the invention is to provide a compound nutgrass galingale rhizome capsule and a preparation method thereof.

The traditional Chinese medicine composition is prepared from the following raw materials in parts by weight: 450 portions of rhizoma cyperi 350-.

It is to be noted that the nutgrass galingale rhizome can be, but is not limited to, 350 parts, 360 parts, 370 parts, 380 parts, 390 parts, 400 parts, 410 parts, 420 parts, 430 parts, 440 parts or 450 parts; corydalis tuber may be, but is not limited to, 430 parts, 440 parts, 450 parts, 460 parts, 470 parts, 480 parts, 490 parts, or 500 parts; trichosanthis radix may be, but is not limited to, 430 parts, 440 parts, 450 parts, 460 parts, 470 parts, 480 parts, 490 parts, or 500 parts; wild buckwheat can be, but is not limited to, 750 parts, 760 parts, 770 parts, 780 parts, 790 parts, 800 parts, 810 parts, 820 parts, 830 parts, 840 parts, or 850 parts; aspongopus may be, but is not limited to, 500 parts, 510 parts, 520 parts, 530 parts, 540 parts, 550 parts, 560 parts, 570 parts, 580 parts, 590 parts, or 600 parts; the gallnut can be, but is not limited to, 200 parts, 210 parts, 220 parts, 230 parts, 240 parts, 250 parts, 260 parts, 270 parts, 280 parts, 290 parts or 300 parts; the hawthorn can be, but is not limited to, 150 parts, 160 parts, 170 parts, 180 parts, 190 parts, 200 parts, 210 parts, 220 parts, 230 parts, 240 parts or 250 parts; the sophora flavescens can be but is not limited to 100 parts, 110 parts, 120 parts, 130 parts, 140 parts, 150 parts, 160 parts, 170 parts, 180 parts, 190 parts or 200 parts.

In a preferred embodiment, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 380 portions of nutgrass galingale rhizome, 500 portions of corydalis tuber, 460 portions, 500 portions of trichosanthes root, 780 portions of wild buckwheat, 580 portions of aspongopus, 260 portions of nutgall, 180 portions of hawthorn and 180 portions of kuh-seng.

In a more preferred embodiment, the traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 400 parts of rhizoma cyperi, 480 parts of rhizoma corydalis, 480 parts of trichosanthes root, 800 parts of wild buckwheat rhizome, 560 parts of aspongopus, 240 parts of Chinese gall, 200 parts of hawthorn and 160 parts of radix sophorae flavescentis.

The application of the traditional Chinese medicine composition in preparing medicines for treating gastric cancer, cholangiocarcinoma or liver cancer.

In a preferred embodiment, the dosage form of the above medicine comprises capsules, granules, tablets, pills, oral liquid or decoction, and preferably capsules. The general process of preparing different dosage forms after obtaining an extract of the drug substance is well known to those of ordinary skill in the art.

A compound rhizoma cyperi capsule comprises the raw materials of the traditional Chinese medicine composition provided by the invention.

The compound rhizoma Cyperi capsule is taken 3 times a day after meals, 5 granules are taken once, 30 days is a treatment course, and 3 treatment courses can be taken continuously. Use with cautions for pregnant women. Each capsule contains 0.4g of the decoction pieces equivalent to 3.32 g.

The preparation method of the compound nutgrass galingale rhizome capsule comprises the following steps: extracting radix Sophorae Flavescentis, Trichosanthis radix, rhizoma corydalis and Aspongopus with ethanol respectively, extracting rhizoma Fagopyri Dibotryis, rhizoma Cyperi, fructus crataegi and Galla chinensis with water, adding excipient to the obtained extract, and making into compound rhizoma Cyperi capsule.

In a preferred embodiment, the preparation method comprises the following steps:

reflux-extracting radix sophorae flavescentis, radix trichosanthis, rhizoma corydalis and aspongopus respectively by using 58% -62% ethanol for 1-4 times, wherein each time lasts for 1-2h, sequentially filtering, concentrating and drying the extract of the radix sophorae flavescentis, the radix trichosanthis or the rhizoma corydalis for later use, and sequentially filtering and concentrating the extract of the aspongopus into thick paste;

decocting wild buckwheat rhizome, nutgrass galingale rhizome, hawthorn and Chinese gall in water for 1-4 times, and each time for 1-2 hours to obtain an extracting solution, and sequentially filtering, concentrating and drying the extracting solution for later use;

and (c) adding excipient into the extracts obtained in the step (a) and the step (b) to prepare the compound nutgrass galingale rhizome capsule.

In a more specific embodiment, the preparation method comprises the following steps: reflux-extracting radix Sophorae Flavescentis, Trichosanthis radix and rhizoma corydalis with 60% ethanol for 3 times, each for 1.5 hr, mixing the three extractive solutions, filtering, concentrating, and drying. Reflux-extracting Aspongopus with 60% ethanol for 3 times, each for 1.5 hr, filtering, and concentrating to obtain soft extract. Decocting rhizoma Fagopyri Dibotryis, rhizoma Cyperi, fructus crataegi and Galla chinensis in water for 3 times, each for 1.5 hr, mixing the three extractive solutions, filtering, concentrating, and drying. Adding appropriate amount of sodium carboxymethyl starch into the above extract, mixing, granulating, drying, adding 3g magnesium stearate, mixing, and making into capsule 1000.

Each Chinese medicinal material in the Chinese medicinal composition has the following source and effect.

The rhizoma Cyperi is dried rhizome of Cyperus rotundus L of Cyperaceae. Pungent, slightly bitter, slightly sweet and neutral in nature. It enters liver and triple energizer meridians. The efficacy and the effect are as follows: has the functions of dispersing stagnated liver qi, regulating menstruation and relieving pain, and belongs to qi-regulating medicine. It is indicated for incoordination between liver and stomach, qi stagnation, distending pain of chest, abdomen and hypochondrium, phlegm and fluid retention, menoxenia, metrorrhagia, metrostaxis and leukorrhagia.

Rhizoma corydalis is dried tuber of corydalis tuber of Papaveraceae. Warm in nature, pungent and bitter in flavor. It enters liver and spleen meridians. The efficacy and the effect are as follows: promoting blood circulation to remove blood stasis, regulating qi and relieving pain, belonging to the blood circulation-promoting and pain-relieving herbs classified under the blood circulation-promoting and blood stasis-removing herbs. Can be used for treating chest and hypochondrium, abdominal pain, thoracic obstruction, cardialgia, amenorrhea, dysmenorrhea, puerperal blood stasis, and traumatic injury with swelling and pain.

Trichosanthis radix is root of Trichosanthes kirilowii Maxim belonging to Cucurbitaceae. Slightly cold in nature, sweet and slightly bitter in taste. It enters lung and stomach meridians. The efficacy and the effect are as follows: clearing heat, promoting the production of body fluid, relieving swelling and expelling pus, which belongs to the category of heat-clearing herbs. It is indicated for feverish sensation with polydipsia, dry cough due to lung heat, diabetes due to internal heat, sores and ulcers, and pyogenic infections.

Rhizome of Fagopyrum dibotrys of Polygonaceae. Cool in nature, astringent and slightly pungent in flavor. It enters lung meridian. The efficacy and the effect are as follows: clearing heat and removing toxicity, expelling pus and removing blood stasis, which belongs to the category of heat-clearing herbs. It is indicated for lung abscess, swollen and sore throat due to accumulation of heat-toxin, lung heat dyspnea and cough, scrofula, carbuncle, sore, furuncle and venomous snake bite; poor appetite, abdominal distension, malnutritional stagnation and emaciation due to spleen dysfunction.

The Aspongopus is the insect body of Aspongopus of Orchidaceae. Warm in nature, pungent and salty in flavor. It enters liver, spleen and kidney meridians. The efficacy and the effect are as follows: promoting qi circulation, alleviating pain, warming kidney and strengthening yang, which belongs to qi-regulating drugs. It is indicated for distending pain in chest and hypochondrium and epigastrium due to incoordination between liver and stomach or cold accumulation in middle energizer, lumbago and impotence due to kidney yang deficiency.

Galla chinensis is insect gall on leaves of Rhus chinensis, Populus trifoliata or Populus deltoides belonging to Anacardiaceae, and is mainly formed by parasitizing Galla chinensis aphid. Cold in nature, sour and astringent in taste. It enters lung meridian, large intestine meridian and kidney meridian. The efficacy and the effect are as follows: astringents herbs that astringe lung and purge fire, astringe intestines to check diarrhea, astringe lung and stop bleeding, astringe dampness and heal wound belong to the category of astringents. It is indicated for chronic cough due to lung deficiency, chronic diarrhea and dysentery due to lung heat with phlegm, spontaneous perspiration and night sweat, diabetes, hemafecia and hemorrhoidal bleeding, traumatic hemorrhage, carbuncle, swelling, sore and toxicity, and skin ulceration.

The fructus crataegi is dried mature fruit of Crataegus pinnatifida or Crataegus pinnatifida of Rosaceae. Slightly warm in nature, sour and sweet in taste. It enters spleen, stomach and liver meridians. The efficacy and the effect are as follows: promoting digestion, strengthening spleen, promoting qi circulation and removing blood stasis, which belongs to the digestant medicine. Can be used for treating dyspepsia, infantile dyspepsia, abdominal distention and pain, dysentery, diarrhea, dysmenorrhea, puerperal abdominal pain due to blood stasis, and hyperlipidemia.

Radix Sophorae Flavescentis is dried root of radix Sophorae Flavescentis of Leguminosae. Bitter and cold. They enter heart meridian, liver meridian, stomach meridian, large intestine meridian and bladder meridian. The efficacy and the effect are as follows: clear heat and dry dampness, kill parasites and induce diuresis. Can be used for treating dysentery with heat, hematochezia, jaundice, anuria, leucorrhea with red and white discharge, pudendal swelling, pudendal pruritus, eczema, skin pruritus, scabies, tinea, leprosy, and trichomonas vaginitis.

The invention has the beneficial effects that:

the traditional Chinese medicine composition has the effects of regulating qi, relieving pain, clearing heat and resolving masses, and is used for treating liver cancer, gastric cancer or cholangiocarcinoma. In the formula, the nutgrass galingale rhizome is used as a monarch drug for soothing the liver and relieving depression and regulating qi and relieving epigastric distention; the radix trichosanthis has the effects of clearing heat and purging fire, promoting the production of body fluid to quench thirst, reducing swelling and expelling pus, softening hardness and dissipating stagnation, and the rhizoma corydalis has the effects of activating blood, promoting qi circulation and relieving pain, and the two medicines have the effects of clearing heat, promoting the production of body fluid, promoting blood circulation to relieve pain and softening hardness and dissipating stagnation together and are used as ministerial medicines; the aspongopus regulates qi and relieves pain, warms middle-jiao and strengthens yang, the gallnut astringes intestines to stop diarrhea and stops bleeding, astringes dampness and heals sore, the hawthorn strengthens spleen to promote digestion, promotes qi circulation and removes stasis, removes turbidity and reduces fat, the wild buckwheat rhizome clears away heat and toxic material, the four medicines play the roles of regulating qi and relieving pain, stopping bleeding in a astringing way and clearing away heat and toxic material together and are used as adjuvant medicines; kuh-seng clears heat and induces diuresis as a guiding drug. The whole formula regulates qi to alleviate pain, clears heat and removes stasis.

The traditional Chinese medicine composition has obvious curative effect, the total effective rate of treating the gastric cancer reaches 89.39%, the total effective rate of treating the bile duct cancer reaches 86.73%, and the total effective rate of treating the liver cancer reaches 91.36%, so that the traditional Chinese medicine composition is an ideal medicine for treating the gastric cancer, the bile duct cancer and the liver cancer.

Drawings

FIG. 1 is a diagram of the results of citrulline thin layer chromatography experiments, wherein 1, 2 and 3 are compound rhizoma Cyperi capsules; s is a citrulline reference substance;

FIG. 2 is a diagram of the results of tetrahydropalmatine thin layer chromatography experiments, wherein 1, 2 and 3 are compound rhizoma Cyperi capsule; s is tetrahydropalmatine reference substance.

Detailed Description

Hereinafter, specific embodiments of the present invention will be described in detail with reference to the accompanying drawings.

Example 1

A traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 350g of rhizoma cyperi, 500g of rhizoma corydalis, 430g of trichosanthes root, 850g of wild buckwheat rhizome, 500g of aspongopus, 300g of Chinese gall, 150 g of hawthorn and 200g of radix sophorae flavescentis.

Example 2

A traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 450g of rhizoma cyperi, 430g of rhizoma corydalis, 500g of radix trichosanthis, 750g of wild buckwheat rhizome, 600g of aspongopus, 200g of gallnut, 250g of hawthorn and 100g of radix sophorae flavescentis.

Example 3

A traditional Chinese medicine composition is prepared from the following raw material medicines in parts by weight: 400g of rhizoma cyperi, 480g of rhizoma corydalis, 480g of radix trichosanthis, 800g of wild buckwheat rhizome, 560g of aspongopus, 240g of gallnut, 200g of hawthorn and 160g of radix sophorae flavescentis.

Example 4

A compound rhizoma Cyperi Capsule is prepared from the Chinese medicinal materials of example 3 by reflux extracting radix Sophorae Flavescentis, Trichosanthis radix and rhizoma corydalis with 60% ethanol for 3 times (1.5 hr each time), mixing the three extractive solutions, filtering, concentrating, and drying. Reflux-extracting Aspongopus with 60% ethanol for 3 times, each for 1.5 hr, filtering, and concentrating to obtain soft extract. Decocting rhizoma Fagopyri Dibotryis, rhizoma Cyperi, fructus crataegi and Galla chinensis in water for 3 times, each for 1.5 hr, mixing the three extractive solutions, filtering, concentrating, and drying. Adding appropriate amount of sodium carboxymethyl starch into the above extract, mixing, granulating, drying, adding 3g magnesium stearate, mixing, and making into capsule 1000.

Example 5 active ingredient identification

(1) Taking 2 granules of the product, removing capsule shell, grinding, adding 10mL of 50% ethanol solution, performing ultrasonic treatment for 30 minutes, and filtering to obtain filtrate as test solution. Dissolving citrulline control in 50% ethanol to obtain solution containing 0.2mg per 1mL as control solution. According to thin layer chromatography (Chinese pharmacopoeia), 1 μ L of each of the sample solution and the reference solution is respectively dropped on the same silica gel G thin layer plate, n-butanol-absolute ethyl alcohol-glacial acetic acid-water (8:2:2:3) is used as developing agent, upward development is carried out, the sample is taken out, air-dried, ninhydrin test solution is sprayed, and the spot is heated at 105 ℃ until the color development is clear. The test chromatogram showed spots of the same color at the positions corresponding to the control chromatogram, and the results are shown in FIG. 1.

(2) Taking 12 granules of the product, removing capsule shell, grinding, adding 20mL of methanol, performing ultrasonic treatment for 20 minutes, filtering, evaporating filtrate to dryness, dissolving residue with 20mL of water, adding concentrated ammonia reagent to adjust to alkalinity, extracting with diethyl ether for 2 times, each time 15mL, mixing diethyl ether solution, evaporating to dryness, adding 1mL of methanol to residue to obtain sample solution; taking tetrahydropalmatine as reference substance, adding ethanol to obtain solution containing 0.5mg per 1mL, taking as reference substance solution, performing thin layer chromatography (Chinese pharmacopoeia) test, sucking 1 μ L of the reference substance solution, adding 3 μ L of test solution, respectively dropping on the same silica gel G thin layer plate, placing in a developing tank pre-saturated with developing agent with n-hexane-chloroform-methanol-triethylamine (7.5:4:1:0.1) as developing agent, developing, taking out, air drying, taking out after placing in an iodine tank for about 3 min, volatilizing iodine adsorbed on the plate, and inspecting under ultraviolet lamp (365 nm). The test chromatogram showed fluorescent spots of the same color at the positions corresponding to the control chromatogram, and the results are shown in FIG. 2.

EXAMPLE 6 clinical efficacy

First, clinical case selection

1. Diagnostic criteria for gastric cancer

Proved by gastroscope biopsy and operation pathology, the western medicine diagnosis conforms to the diagnosis standard of the related gastric cancer in the newly compiled standard for diagnosis and treatment of common malignant tumors, namely gastric cancer booklet, and the clinical stages are III B stage and IV stage, which have symptoms of certain degree of fullness and discomfort, dyspepsia, epigastric pain, anemia, anorexia and the like;

the traditional Chinese medicine diagnosis conforms to the diagnosis standard of epigastric pain in the guiding principle of clinical research of traditional Chinese medicine, and the syndrome differentiation belongs to the phlegm-damp coagulation syndrome, and the symptoms of short breath, hypodynamia, anorexia, epigastric pain, listlessness and the like appear;

a total of 132 observed cases, 72 men and 60 women; age 32-73 years; the course of disease is 6 months to 3 years; in the focus part, 58 cases of antrum, 42 cases of corpus gastris and 32 cases of fundus cardia part; in the clinical stage, 76 cases in stage III and 56 cases in stage IV.

2. Gallbladder cancer diagnostic standard

The gallbladder cancer patient is confirmed to be diagnosed by imaging and pathological examination according to the relevant diagnosis standard; with varying degrees of dull pain in the right upper abdomen, fever, nausea and vomiting;

a total of 98 cases were observed, 61 men and 37 women; the age is 37-70 years.

3. Liver cancer diagnostic standard

(1) Before treatment, AFP, abdominal CT, B-ultrasonic examination, etc. are performed, or primary liver cancer is diagnosed by pathological histology and/or cytology examination. The diagnostic criteria were in accordance with "Primary liver cancer diagnostic criteria" (revised in 2001 by the national cancer institute for cancer prevention).

(2) A total of 243 patients were observed, 182 male and 61 female. The younger age is 22 years old, and the longest is 83 years old.

(3) Staging according to "primary liver cancer staging standard" (revised by the national cancer institute for cancer liver cancer, committee 2001): phase i (early): 37 cases, stage ii (middle stage): 127 cases, stage iii (late): 79 cases.

Traditional Chinese medicine syndrome differentiation: 42 cases of qi stagnation and blood stasis, 136 cases of damp-heat accumulation, and 65 cases of spleen-kidney deficiency.

II, excluding the case standard:

(ii) other malignant tumors; ② combining other visceral diseases; (iii) presence of cognitive dysfunction or disturbance of consciousness; fourthly, psychosis is treated; immune dysfunction; diseases of the blood system; seventhly, the study medicine is allergic.

Thirdly, a test method:

1. 132 cases of gastric cancer were observed; 98 cases of bile duct cancer; 243 cases of liver cancer.

2. Administration: the medicine capsule of the invention is taken with warm boiled water 0.4 x 5 capsules each time, 3 times a day.

3. The course of treatment is as follows: 3 months is 1 course of treatment, 3 courses of treatment are taken, and other medicines related to the disease are not used in the clinical verification period.

Fourthly, the treatment effect judgment standard is as follows:

1. traditional Chinese medicine syndrome integration: the scores are 0, 2, 4 and 6 according to the severity of the symptoms (short breath, hypodynamia, anorexia, epigastric pain and listlessness), and the lower the score is, the better the score is.

2. The clinical curative effect is as follows: the judgment result is as follows:

firstly, completely relieving: the focus disappears, and the duration is more than 1 month;

secondly, partial relief: the focus is reduced by more than 50 percent, and the duration is more than 1 month;

③ stabilizing: the focus is reduced by less than or equal to 50 percent, and the duration is more than 1 month;

and fourthly, progress: the focus is reduced by less than or equal to 25 percent or enlarged;

fifthly, test results:

TABLE 1 therapeutic effect analysis table for gastric cancer, cholangiocarcinoma and hepatocarcinoma

Standard of therapeutic effect	Number of cases	Complete relief, for example	Partial relief, for example	Stabilization of	Example of progress	Effective rate%
							Gastric cancer disorders	132	18	67	33	14	89.39
Bile duct cancer disorders	98	16	51	18	13	86.73
							Liver cancer disease	243	19	106	97	21	91.36

The test results show that the compound nutgrass galingale rhizome capsule has the effects of regulating qi, relieving pain, clearing heat and resolving masses. Can be used for treating hepatocarcinoma, gastric cancer, and cancer of bile duct. The medicine has obvious curative effect, the total effective rate for treating gastric cancer reaches 89.39%, the total effective rate for treating bile duct cancer reaches 86.73%, and the total effective rate for treating liver cancer reaches 91.36%, and is an ideal medicine for treating gastric cancer, bile duct cancer and liver cancer.

Example 7 typical cases

Gastric cancer:

1. zhangyi, male, 42 years old, patients suddenly feel stomachache, nausea, epigastric fullness, and the local hospital diagnoses the gastric adenocarcinoma through examination, because the body is weak, chemotherapy and operation are not performed, the patient is introduced to take the compound nutgrass galingale rhizome capsule three times a day, 0.4 x 5 capsules each time, the stomachache is relieved after taking the capsule for 20 days, the appetite is increased, the patient feels normal after taking the capsule for 3 months, the body weight is increased by 5 kilograms, and the patient is rechecked after taking the capsule for 9 months, and the tumor disappears. The patient is not relieved and is required to continue taking the medicine, and then the medicine is taken once a day for 3 years till the last follow-up visit is not relapsed.

2. When applied to a certain time, male, age 52, will feel painful in all times due to the fullness and distention of the stomach, and will cause pain in the hypochondrium, hiccup, vomiting and emaciation, and will be diagnosed in local hospitals, and the diagnosis will be confirmed as gastric adenocarcinoma through examination. After the compound nutgrass galingale rhizome capsule is taken three times a day, 0.4 x 5 capsules are taken each time, pain disappears, hiccup and vomiting symptoms disappear after the capsule is taken for 1 month, appetite is increased, discomfort symptoms basically do not exist after the capsule is taken for 9 months, and the tumor disappears after the capsule is rechecked by a local hospital.

Bile duct cancer:

1. for a woman in the age of 45, bile duct cancer is confirmed to be diagnosed by local hospital examination due to dull pain of the right upper abdomen, fever, nausea and vomiting, the compound nutgrass galingale rhizome capsule is introduced to be taken three times a day, 0.4 x 5 capsules are taken each time, the appetite, pain, jaundice, fatigue and vomiting are obviously improved after 1 month of taking, the patient feels the same as a normal person after taking for 6 months, and tumor cells are not found by reexamination.

2. After the diagnosis of 1 month, the compound nutgrass galingale rhizome capsule is taken three times a day, 0.4 x 5 capsules are taken each time, the jaundice disappears after 3 months, the appetite is recovered, the weight is increased, the tumor disappears after 9 months of reexamination by the local hospital, and the tumor does not relapse until the last follow-up visit.

Liver cancer:

1. a certain patient, male, 65 years old, was diagnosed with hepatocellular carcinoma in Shandong Longkou Ministry Hospital, with a maximum tumor diameter of 5cm and more than 10 scattered tumors, and could not eat, abdominal distension, pain, dyspnea, lie in bed, and could not take care of oneself. The compound nutgrass galingale rhizome capsule is taken three times a day by introduction, 0.4 x 5 granules are taken each time, and the pain of a patient is relieved after the patient takes the capsule for 10 days, so that the patient can eat the capsule; after the medicine is taken for 1 month, the patient can get out of bed to move, and the pain disappears; after the medicine is taken for 6 months, the color Doppler ultrasound of the tumor shows vagueness, and after 9 months, the tumor disappears after the line inspection. No abnormality is found until the last follow-up visit.

2. After the patient is examined by images, the spacious change of right hepatic lobe, mass of 3.5 x 4cm, ascites and alpha fetoprotein value of 684 are found. The compound nutgrass galingale rhizome capsule is taken three times a day, 0.4 x 5 capsules are taken each time, and the alpha fetoprotein value returns to normal after the capsule is taken for 3 months. After 9 months of administration, the patient is examined by CT to have a tumor disappeared, and then the patient is taken 1 time a day, so far (2021 years old) the patient is healthy and well-known for 70 years.

The above description is only for the purpose of illustrating the preferred embodiments of the present invention and is not to be construed as limiting the invention, and any modifications, equivalents, improvements and the like that fall within the spirit and principle of the present invention are intended to be included therein.

Claims

1. The traditional Chinese medicine composition is characterized by being prepared from the following raw material medicines in parts by weight: 450 portions of rhizoma cyperi 350-.

2. The traditional Chinese medicine composition according to claim 1, which is prepared from the following raw materials in parts by weight: 380 portions of nutgrass galingale rhizome, 500 portions of corydalis tuber, 460 portions, 500 portions of trichosanthes root, 780 portions of wild buckwheat, 580 portions of aspongopus, 260 portions of nutgall, 180 portions of hawthorn and 180 portions of kuh-seng.

3. The traditional Chinese medicine composition according to claim 2, which is prepared from the following raw materials in parts by weight: 400 parts of rhizoma cyperi, 480 parts of rhizoma corydalis, 480 parts of trichosanthes root, 800 parts of wild buckwheat rhizome, 560 parts of aspongopus, 240 parts of Chinese gall, 200 parts of hawthorn and 160 parts of radix sophorae flavescentis.

4. Use of the Chinese medicinal composition of any one of claims 1-3 in the preparation of a medicament for treating gastric cancer, cholangiocarcinoma or liver cancer.

5. The use according to claim 4, wherein the medicament is in the form of capsules, granules, tablets, pills, oral liquid or decoction, preferably capsules.

6. A compound nutgrass galingale rhizome capsule, which is characterized in that the raw material of the compound nutgrass galingale rhizome capsule comprises the traditional Chinese medicine composition of any one of claims 1 to 3.

7. The preparation method of the compound nutgrass galingale rhizome capsule as claimed in claim 6, which is characterized by comprising the following steps: extracting radix Sophorae Flavescentis, Trichosanthis radix, rhizoma corydalis and Aspongopus with ethanol respectively, extracting rhizoma Fagopyri Dibotryis, rhizoma Cyperi, fructus crataegi and Galla chinensis with water, adding excipient to obtain compound rhizoma Cyperi capsule.

8. The method of manufacturing according to claim 7, comprising the steps of:

decocting wild buckwheat rhizome, nutgrass galingale rhizome, hawthorn and Chinese gall in water for 1 to 4 times, and each time lasts for 1 to 2 hours, and filtering, concentrating and drying the obtained extract in sequence for later use;

9. The method of claim 8, wherein the excipients include sodium carboxymethyl starch and magnesium stearate.

10. The preparation method according to claim 9, wherein in the step (c), the extracts obtained in the step (a) and the step (b) are mixed with sodium carboxymethyl starch, granulated and dried, then magnesium stearate is added and mixed, and the mixture is encapsulated to obtain the compound rhizoma cyperi capsule.