CN114617858B - Traditional Chinese medicine acne-removing microcrystalline paste and preparation method thereof - Google Patents
Traditional Chinese medicine acne-removing microcrystalline paste and preparation method thereof Download PDFInfo
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- CN114617858B CN114617858B CN202210271516.4A CN202210271516A CN114617858B CN 114617858 B CN114617858 B CN 114617858B CN 202210271516 A CN202210271516 A CN 202210271516A CN 114617858 B CN114617858 B CN 114617858B
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Abstract
The invention belongs to the field of traditional Chinese medicine acne removal patches, and particularly discloses a traditional Chinese medicine acne removal microcrystalline patch and a preparation method thereof; the plaster is prepared from the following traditional Chinese medicine raw materials: oregano, radix Arnebiae, radix Sophorae Flavescentis, herba Centellae, scutellariae radix, saviae Miltiorrhizae radix, rhizoma Atractylodis, taraxacum officinale leaf, and Poria; specifically, the plaster part is prepared from the following traditional Chinese medicine raw materials, by weight, 100 parts of origanum vulgare, 40-80 parts of lithospermum, 40-80 parts of radix sophorae flavescentis, 30-60 parts of centella asiatica, 30-60 parts of radix scutellariae, 20-40 parts of radix salviae miltiorrhizae, 10-20 parts of rhizoma atractylodis, 5-15 parts of dandelion leaves and 4-8 parts of poria cocos; the traditional Chinese medicine acne-removing microcrystalline patch prepared by the invention is based on pure traditional Chinese medicine extracts, and various effects of acne removal, moisture preservation, moistening, whitening, tightening and the like can be achieved by mutual cooperation of the natural components, so that the traditional Chinese medicine acne-removing microcrystalline patch has a good transdermal effect, is free of toxic and side effects, long in shelf life and long in acting stability.
Description
Technical Field
The invention belongs to the field of traditional Chinese medicine acne removing patches, and particularly discloses a traditional Chinese medicine acne removing microcrystalline patch and a preparation method thereof.
Background
Acne, comedo, and pimple are collectively known as acne in medicine, and are a common chronic disease of sebaceous glands, and when the cause is puberty, hormones in the body stimulate hair growth, the sebaceous glands secrete vigorously, and pores are blocked to form a core of comedo, i. Micro-acne is invisible, a period of 7 to 9 months from formation to outgrowth of the skin surface. The blockage of pores by micro-acne induces inflammation and is the source of papules, pustules, nodules and cysts. The traditional treatment only eliminates the acne on the surface, and the micro-powder thorns are stopped for a period of time and grow out, so that the situation of repeated attacks of the acne is formed. The traditional Chinese medicine considers that the skin is a mirror of the five viscera, and acnes on the surface of the skin are closely related to the five viscera and six viscera of a person, and the acnes grow on the surface of the skin but are closely related to viscera dysfunction. The traditional Chinese medicine holds that: the cause of acne is: the face, nose, chest and back are the lung, and this disease is usually caused by wind-heat resistance of the lung meridian on the skin; or by overfeeding fat, sweet, greasy and spicy food, spleen and stomach heat, damp heat and endogenous, fumigating the noodles; or the skin is blocked by the ascending of yang heat and the pulsation of wind-cold due to the youth body, the rigidity of blood and qi. The causes of acne are known in traditional Chinese medicine to be in various cases: deficiency of kidney yin, lung heat, stomach heat and blood heat often lead to vaccinia.
The traditional acne removing method mainly comprises antibiotic treatment, laser treatment or hormone treatment, and the treatment method has the defects of large side effect, single curative effect, easy recurrence and the like. The traditional Chinese medicine acne-removing cream has small side effect, but the curative effect is often not obvious, and meanwhile, although a plurality of beneficial Chinese medicine components are used, the traditional Chinese medicine acne-removing cream is difficult to absorb, so that the defects are urgently needed to be solved.
Disclosure of Invention
Aiming at the defects, the invention discloses a traditional Chinese medicine acne-removing microcrystalline patch and a preparation method thereof. The traditional Chinese medicine acne-removing microcrystalline patch disclosed by the invention has the advantages that the medicinal components are based on pure traditional Chinese medicine extracts, and the natural components cooperate with each other to achieve various effects of acne removal, moisture retention, moistening, whitening, tightening and the like, so that the acne-removing microcrystalline patch has a good transdermal effect, is free of toxic and side effects, long in shelf life and long in acting stability.
The technical scheme of the invention is as follows:
a Chinese medicinal acne-removing microcrystalline plaster is prepared from the following Chinese medicinal materials: oregano, radix Arnebiae, radix Sophorae Flavescentis, herba Centellae, scutellariae radix, saviae Miltiorrhizae radix, rhizoma Atractylodis, taraxacum officinale leaf, and Poria. Oregano has effects of relieving exterior syndrome, regulating qi-flowing, clearing summer-heat, and promoting diuresis; lithospermum is sweet, salty and cold in nature. It enters heart and liver meridians. Has the functions of cooling blood, promoting blood circulation, removing toxic substance and promoting eruption. Ku Shen has the actions of clearing heat and drying dampness, killing parasites and promoting urination. Can be used for treating dysentery, hematochezia, jaundice, uroschesis, leucorrhea with reddish discharge, pudendum swelling, pudendum itch, eczema, skin sore, skin itch, mange leprosy, and trichomonas vaginitis. Herba Centellae has effects of clearing heat, promoting diuresis, removing toxic substances and detumescence, and is commonly used for damp-heat jaundice, heatstroke diarrhea, stranguria with blood, carbuncle, swelling and sore, and traumatic injury. The origanum vulgare, lithospermum, kuh-seng and centella asiatica serve as monarch drugs, and play a main role in detoxifying and promoting eruption, and clearing heat and drying dampness. Radix Scutellariae has the effects of clearing heat, eliminating dampness, purging pathogenic fire, removing toxic substances, stopping bleeding, and preventing miscarriage; the red sage root has the effects of promoting blood circulation, removing blood stasis, dredging channels, relieving pain, clearing away heart-fire, relieving restlessness, cooling blood and eliminating carbuncles. Baical skullcap root and red sage root are used as ministerial drugs in the recipe and auxiliary monarch drugs for playing the roles of cooling blood and resolving carbuncles. Rhizoma atractylodis is used for eliminating dampness, strengthening spleen, dispelling wind, dispelling cold and improving eyesight; dandelion is mainly used for furuncle, swelling and toxicity, acute mastitis, scrofula, conjunctival congestion, pharyngalgia, pulmonary abscess, intestinal abscess, jaundice due to damp-heat, stranguria due to heat; poria has effects of promoting diuresis, eliminating dampness, invigorating spleen, and calming heart; the medicine is used as adjuvant medicine to assist monarch medicine and ministerial medicine to strengthen the therapeutic effect.
Further, the traditional Chinese medicine acne-removing microcrystalline paste is prepared from the following traditional Chinese medicine raw materials in parts by weight:
further, the traditional Chinese medicine acne-removing microcrystalline paste is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the embodiment proves that the traditional Chinese medicine acne-removing microcrystalline patch prepared by the proportion has excellent efficacy.
Furthermore, the plaster part of the traditional Chinese medicine acne-removing microcrystalline plaster also contains a bactericide and a preservative.
Furthermore, the traditional Chinese medicine acne-removing microcrystalline paste is characterized in that the bactericide is polyquaternium-73.
Furthermore, the traditional Chinese medicine acne-removing microcrystalline paste is characterized in that the preservative is o-cymene-5-ol. The addition amount of the preservative is 0.1% of the mass of the final ointment.
The preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing traditional Chinese medicine decoction pieces of origanum vulgare, lithospermum, radix sophorae flavescentis, centella asiatica, radix scutellariae, radix salviae miltiorrhizae, rhizoma atractylodis, dandelion leaves and poria cocos according to the formula amount;
2) Mixing the above Chinese medicinal decoction pieces, and pulverizing to average particle diameter of 0.2-1 μm in a superfine pulverizer to obtain Chinese medicinal mixed fine powder;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:20-1:60, stirring, heating and evaporating at 50-80 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 70-90 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 50-70 ℃ for dehydration treatment for 2-4h, and performing lamination forming with a film when the water content is detected to be 10-18%, so as to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 3-6%;
7) And packaging the membrane in a closed space with the temperature of 15-25 ℃ and the humidity of 20-40%.
The preparation method is mild, has few steps, and retains natural components to the maximum extent.
Further, the preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing traditional Chinese medicine decoction pieces of origanum vulgare, lithospermum, radix sophorae flavescentis, centella asiatica, radix scutellariae, radix salviae miltiorrhizae, rhizoma atractylodis, dandelion leaves and poria cocos according to the formula amount;
2) Mixing the above Chinese medicinal decoction pieces uniformly, placing into a superfine pulverizer, and pulverizing to average particle diameter of 0.2 μm to obtain Chinese medicinal mixed fine powder;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:40, stirring, heating and evaporating at 65 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 80 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 60 ℃ for dehydration treatment for 3 hours, and performing press molding with a film when the water content is detected to be 14%, so as to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 4.5%;
7) The encapsulation of the film was carried out in a closed space at a temperature of 20 ℃ and a humidity of 30%.
From the above technical scheme, the invention has the following beneficial effects:
(1) The invention is based on the theory of traditional Chinese medicine, and selects origanum vulgare, lithospermum, kuh-seng, centella asiatica, baikal skullcap root, red sage root, rhizoma atractylodis, dandelion leaves and poria cocos as main functional raw materials aiming at the pathogenesis of acne. Contains effective components with strong inhibition effect on propionibacterium acnes and staphylococcus aureus, can radically cure acne from the disease source, prevents recurrence and has good acne removing effect.
(2) The traditional Chinese medicine acne-removing microcrystalline paste prepared by the invention adopts the high-purity natural herbal extract as the main raw material, so that the prepared acne-removing paste has stable active ingredients and few impurities, reduces the influence of the impurities on the acne-removing performance, ensures the continuous and stable effect of the active ingredients, has good effect on the treatment and daily nursing of acne, has high stability, and can ensure long-term use effect.
(3) The traditional Chinese medicine acne-removing microcrystalline plaster provided by the invention has the advantages that the micro needle is formed on the plaster surface to puncture the stratum corneum, and the transdermal absorption effect is good; the components cooperate with each other to achieve various effects of moisturizing, moistening, whitening, tightening, drying, spot-fading, anti-inflammation and the like, and the beverage has the advantages of no toxic or side effect, long shelf life and long and stable effect.
Detailed Description
The following description of the embodiments of the present invention will be made clearly and completely, and it is apparent that the described embodiments are only some embodiments of the present invention, but not all embodiments. All other embodiments, which can be made by those skilled in the art based on the embodiments of the invention without making any inventive effort, are intended to be within the scope of the invention.
The reagents or instruments used in the examples of the present invention were not manufacturer-identified and were conventional reagent products commercially available.
Example 1
Preparation example
The traditional Chinese medicine acne-removing microcrystalline paste is characterized in that the plaster part is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the plaster part also contains bactericide and preservative, wherein the bactericide is polyquaternium-73, and the preservative is o-cymene-5-ol.
The preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing traditional Chinese medicine decoction pieces of origanum vulgare, lithospermum, radix sophorae flavescentis, centella asiatica, radix scutellariae, radix salviae miltiorrhizae, rhizoma atractylodis, dandelion leaves and poria cocos according to the formula amount;
2) Mixing the above Chinese medicinal decoction pieces uniformly, placing into a superfine pulverizer, and pulverizing to obtain mixed fine powder of Chinese medicinal materials with average particle diameter of 1 μm;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:20, stirring, heating and evaporating at 50 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 70 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 50 ℃ for dehydration treatment, and performing compression molding with a film when the water content is detected to be 10% to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 3%;
7) The encapsulation of the film was carried out in a closed space at a temperature of 15℃and a humidity of 20%.
Example 2
Preparation example
The traditional Chinese medicine acne-removing microcrystalline plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the plaster part also contains bactericide and preservative, wherein the bactericide is polyquaternium-73, and the preservative is o-cymene-5-ol.
The preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing traditional Chinese medicine decoction pieces of origanum vulgare, lithospermum, radix sophorae flavescentis, centella asiatica, radix scutellariae, radix salviae miltiorrhizae, rhizoma atractylodis, dandelion leaves and poria cocos according to the formula amount;
2) Mixing the above Chinese medicinal decoction pieces uniformly, placing into a superfine pulverizer, and pulverizing to obtain mixed fine powder of Chinese medicinal materials with average particle diameter of 1 μm;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:20, stirring, heating and evaporating at 50 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 70 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 50 ℃ for dehydration treatment, and performing compression molding with a film when the water content is detected to be 10% to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 3%;
7) The encapsulation of the film was carried out in a closed space at a temperature of 15℃and a humidity of 20%.
Example 3
Preparation example
The traditional Chinese medicine acne-removing microcrystalline paste is characterized in that the plaster part is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the plaster part also contains bactericide and preservative, wherein the bactericide is polyquaternium-73, and the preservative is o-cymene-5-ol.
The preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing traditional Chinese medicine decoction pieces of origanum vulgare, lithospermum, radix sophorae flavescentis, centella asiatica, radix scutellariae, radix salviae miltiorrhizae, rhizoma atractylodis, dandelion leaves and poria cocos according to the formula amount;
2) Mixing the above Chinese medicinal decoction pieces uniformly, placing into a superfine pulverizer, and pulverizing to average particle diameter of 0.2 μm to obtain Chinese medicinal mixed fine powder;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:40, stirring, heating and evaporating at 65 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 80 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 60 ℃ for dehydration treatment for 3 hours, and performing press molding with a film when the water content is detected to be 14%, so as to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 4.5%;
7) The encapsulation of the film was carried out in a closed space at a temperature of 20 ℃ and a humidity of 30%.
Example 4
Preparation example
The traditional Chinese medicine acne-removing microcrystalline plaster is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the plaster part also contains bactericide and preservative, wherein the bactericide is polyquaternium-73, and the preservative is o-cymene-5-ol.
The preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing traditional Chinese medicine decoction pieces of origanum vulgare, lithospermum, radix sophorae flavescentis, centella asiatica, radix scutellariae, radix salviae miltiorrhizae, rhizoma atractylodis, dandelion leaves and poria cocos according to the formula amount;
2) Mixing the above Chinese medicinal decoction pieces uniformly, placing into a superfine pulverizer, and pulverizing to average particle diameter of 0.5 μm to obtain Chinese medicinal mixed fine powder;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:60, stirring, heating and evaporating at 80 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 90 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 70 ℃ for dehydration treatment for 4 hours, and performing press molding with a film when the water content is detected to be 18%, so as to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 6%;
7) The encapsulation of the film was carried out in a closed space at a temperature of 25℃and a humidity of 40%.
Example 5
Preparation example
The traditional Chinese medicine acne-removing microcrystalline paste is characterized in that the plaster part is prepared from the following traditional Chinese medicine raw materials in parts by weight:
the plaster part also contains bactericide and preservative, wherein the bactericide is polyquaternium-73, and the preservative is o-cymene-5-ol.
The preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing traditional Chinese medicine decoction pieces of origanum vulgare, lithospermum, radix sophorae flavescentis, centella asiatica, radix scutellariae, radix salviae miltiorrhizae, rhizoma atractylodis, dandelion leaves and poria cocos according to the formula amount;
2) Mixing the above Chinese medicinal decoction pieces uniformly, placing into a superfine pulverizer, and pulverizing to average particle diameter of 0.5 μm to obtain Chinese medicinal mixed fine powder;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:60, stirring, heating and evaporating at 80 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 90 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 70 ℃ for dehydration treatment for 4 hours, and performing press molding with a film when the water content is detected to be 18%, so as to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 6%;
7) The encapsulation of the film was carried out in a closed space at a temperature of 25℃and a humidity of 40%.
Comparative example 1
Preparation example
The traditional Chinese medicine acne-removing microcrystalline paste is characterized in that the plaster part is prepared from the following raw materials in parts by weight:
the plaster part also contains bactericide and preservative, wherein the bactericide is polyquaternium-73, and the preservative is o-cymene-5-ol.
The preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing radix Arnebiae, radix Sophorae Flavescentis, herba Centellae, scutellariae radix, saviae Miltiorrhizae radix, rhizoma Atractylodis, herba Taraxaci, and Poria according to formula;
2) Mixing the above Chinese medicinal decoction pieces uniformly, placing into a superfine pulverizer, and pulverizing to average particle diameter of 0.2 μm to obtain Chinese medicinal mixed fine powder;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:40, stirring, heating and evaporating at 65 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 80 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 60 ℃ for dehydration treatment for 3 hours, and performing press molding with a film when the water content is detected to be 14%, so as to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 4.5%;
7) The encapsulation of the film was carried out in a closed space at a temperature of 20 ℃ and a humidity of 30%.
The comparative example was the same as in example 3 except that deionized water was used instead of oregano in the formulation.
Comparative example 2
The common traditional Chinese medicine acne removing paste is purchased in the market.
Test case
80 volunteers were selected and equally divided into 8 groups, and the results of using the traditional Chinese medicine acne-removing microcrystal patches prepared in examples 1 to 5, the acne-removing patches of comparative examples 1 and 2, and no acne-removing patch (blank control), 1 time per day, and the skin feel, bactericidal power, whitening degree, sebum secretion amount change and acne skin loss amount change of 100 days of test use are shown in the following tables 1 and 2:
table 1 comparative test 1
As can be seen from Table 1, compared with the commercial acne-removing patch, the traditional Chinese medicine acne-removing microcrystalline patch disclosed by the invention has the advantages of fresh skin feel, high sterilization rate, reduced skin speckle-removing area and good whitening effect, and the effects of reducing speckle and whitening can be greatly improved by adding oregano as shown in examples and comparative example 1.
Table 2 comparative test 2
As can be seen from Table 2, compared with the commercial acne-removing patch, the acne-removing microcrystalline patch of the traditional Chinese medicine disclosed by the invention has the advantages that the sebum secretion reduction rate (%) for 30 days, the sebum secretion reduction rate (%) for 100 days, the acne reduction rate (%) for 30 days and the acne reduction rate (%) for 100 days are greatly improved; it can be seen from examples and comparative example 1 that the addition of oregano greatly increases the sebum secretion reducing and acne reducing effects of the present product.
In conclusion, the traditional Chinese medicine acne-removing microcrystalline patch prepared by the invention is based on pure traditional Chinese medicine extracts, and various effects of acne removal, moisture retention, moistening, whitening, tightening and the like can be achieved by mutual cooperation of the natural components, so that the patch has a good transdermal effect, is free from toxic and side effects, long in shelf life and long in acting stability.
The above embodiments are only preferred embodiments of the present invention, and the scope of the present invention is not limited thereto, i.e. the present invention is not limited to the above embodiments, but is capable of being modified and varied in all ways according to the following claims and the detailed description.
Claims (1)
1. The traditional Chinese medicine acne-removing microcrystalline paste is characterized in that the plaster part is prepared from the following traditional Chinese medicine raw materials in parts by weight:
oregano 100 parts
50-70 parts of lithospermum
50-70 parts of kuh-seng
40-50 parts of centella asiatica
40-50 parts of baikal skullcap root
25-35 parts of red sage root
12-18 parts of rhizoma atractylodis
8-12 parts of dandelion leaves
5-7 parts of poria cocos;
the plaster part also contains bactericide and preservative;
the bactericide is polyquaternium-73;
the preservative is o-cymene-5-ol;
the preparation method of the traditional Chinese medicine acne-removing microcrystalline patch comprises the following steps:
1) Weighing traditional Chinese medicine decoction pieces of origanum vulgare, lithospermum, radix sophorae flavescentis, centella asiatica, radix scutellariae, radix salviae miltiorrhizae, rhizoma atractylodis, dandelion leaves and poria cocos according to the formula amount;
2) Mixing the above Chinese medicinal decoction pieces uniformly, placing into a superfine pulverizer, and pulverizing to average particle diameter of 0.2 μm to obtain Chinese medicinal mixed fine powder;
3) Placing the mixed fine powder of the traditional Chinese medicines into a 20% ethanol water solution according to the mass ratio of 1:40, stirring, heating and evaporating at 65 ℃ until a paste is obtained;
4) Adding the paste obtained in the step 3 into a bactericide, a preservative and medicinal gelatin, placing into a vacuum emulsifying pot, heating to 80 ℃ under stirring, dissolving uniformly, and vacuumizing and defoaming to obtain original slurry;
5) Placing the primary pulp into a mould, then placing the mould into constant temperature dehumidification equipment at 60 ℃ for dehydration treatment for 3 hours, and performing lamination forming with a film when the water content is detected to be 14%, so as to form miniature needle shapes;
6) Continuously carrying out dehydration treatment in constant-temperature dehumidification equipment after lamination forming, and finishing the dehydration treatment when the water content is detected to be 4.5%;
7) The encapsulation of the film was carried out in a closed space at a temperature of 20 ℃ and a humidity of 30%.
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Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315933A (en) * | 2013-06-08 | 2013-09-25 | 珠海圣原生物科技有限公司 | Traditional Chinese medicine acne-removing extraction liquid and acne-removing paste |
| CN107375111A (en) * | 2017-08-30 | 2017-11-24 | 陈彦彪 | A kind of soluble anti-acne micropin |
| CN112656737A (en) * | 2021-01-28 | 2021-04-16 | 赵如意 | Plant acne-removing composition, preparation and preparation method thereof |
| CN113081894A (en) * | 2021-05-06 | 2021-07-09 | 无锡元旭生物技术有限公司 | Soluble noninvasive acne-removing microneedle patch and preparation method thereof |
-
2022
- 2022-03-18 CN CN202210271516.4A patent/CN114617858B/en active Active
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103315933A (en) * | 2013-06-08 | 2013-09-25 | 珠海圣原生物科技有限公司 | Traditional Chinese medicine acne-removing extraction liquid and acne-removing paste |
| CN107375111A (en) * | 2017-08-30 | 2017-11-24 | 陈彦彪 | A kind of soluble anti-acne micropin |
| CN112656737A (en) * | 2021-01-28 | 2021-04-16 | 赵如意 | Plant acne-removing composition, preparation and preparation method thereof |
| CN113081894A (en) * | 2021-05-06 | 2021-07-09 | 无锡元旭生物技术有限公司 | Soluble noninvasive acne-removing microneedle patch and preparation method thereof |
Non-Patent Citations (1)
| Title |
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| 水光注射与微针美塑联合在痤疮治疗上的临床观察;胡晶;中国医疗美容;第6卷(第12期);第49-52页 * |
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