CN114588071A - Water-light composition for removing acne and shrinking pores and preparation method thereof - Google Patents
Water-light composition for removing acne and shrinking pores and preparation method thereof Download PDFInfo
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- CN114588071A CN114588071A CN202210333313.3A CN202210333313A CN114588071A CN 114588071 A CN114588071 A CN 114588071A CN 202210333313 A CN202210333313 A CN 202210333313A CN 114588071 A CN114588071 A CN 114588071A
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/72—Cosmetics or similar toiletry preparations characterised by the composition containing organic macromolecular compounds
- A61K8/73—Polysaccharides
- A61K8/735—Mucopolysaccharides, e.g. hyaluronic acid; Derivatives thereof
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/40—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds containing nitrogen
- A61K8/41—Amines
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- A—HUMAN NECESSITIES
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/64—Proteins; Peptides; Derivatives or degradation products thereof
- A61K8/65—Collagen; Gelatin; Keratin; Derivatives or degradation products thereof
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A61K8/00—Cosmetics or similar toiletry preparations
- A61K8/18—Cosmetics or similar toiletry preparations characterised by the composition
- A61K8/30—Cosmetics or similar toiletry preparations characterised by the composition containing organic compounds
- A61K8/67—Vitamins
- A61K8/676—Ascorbic acid, i.e. vitamin C
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K8/00—Cosmetics or similar toiletry preparations
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
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- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61Q—SPECIFIC USE OF COSMETICS OR SIMILAR TOILETRY PREPARATIONS
- A61Q19/00—Preparations for care of the skin
- A61Q19/08—Anti-ageing preparations
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K2800/00—Properties of cosmetic compositions or active ingredients thereof or formulation aids used therein and process related aspects
- A61K2800/80—Process related aspects concerning the preparation of the cosmetic composition or the storage or application thereof
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Abstract
The invention discloses a water-light composition for removing acnes and shrinking pores and a preparation method thereof, and the water-light composition has better effects of removing acnes and shrinking pores. A water-light composition for removing acnes and shrinking pores and a preparation method thereof comprise 0.06-0.09 wt% of hyaluronic acid, 0.01-0.04 wt% of collagen, 0.2-0.5 wt% of vitamin C, 0.004-0.01 wt% of fructan, 0.01-0.04 wt% of anti-allergy agent and the balance of buffer solution.
Description
Technical Field
The invention relates to the technical field of medical cosmetology, in particular to a water-light composition for removing acnes and shrinking pores and a preparation method thereof.
Background
The water light composition is a water light needle with composite components, and is a medical and aesthetic product with hyaluronic acid as a basic component. The hyaluronic acid mainly has the effects of moisturizing, locking water and storing water. Hyaluronic acid is a Natural biomolecule widely present in skin and other tissues, has excellent moisturizing effect, and is internationally called Natural MolsturlZlng Factor (NMF). It is the substance with the best moisturizing performance for cosmetics found in nature at present. Hyaluronic acid acts on the surface of skin, and macromolecular hyaluronic acid can form a layer of breathable film on the surface of skin, so that the skin is smooth and moist, the invasion of external bacteria, dust and ultraviolet rays can be blocked, and the skin is protected from being damaged; the small molecular hyaluronic acid can permeate into dermis, has the effects of slightly expanding capillary vessels, increasing blood circulation, improving intermediate metabolism, promoting skin nutrition absorption, has a strong wrinkle-removing function, can increase skin elasticity, and can delay skin aging. The water light needle on the market can compound different effective components according to different functions. The effect of the existing water acupuncture needles on removing acnes and collecting pores needs to be further enhanced.
Disclosure of Invention
The invention aims to provide a water-based polishing composition for removing acnes and shrinking pores and a preparation method thereof, which have better effects of removing acnes and shrinking pores and solve the problems in the prior art.
In order to achieve the above purpose, the technical scheme adopted by the invention is as follows:
a water-light composition for removing acnes and shrinking pores and a preparation method thereof comprise 0.06-0.09 wt% of hyaluronic acid, 0.01-0.04 wt% of collagen, 0.2-0.5 wt% of vitamin C, 0.004-0.01 wt% of fructan, 0.01-0.04 wt% of anti-allergy agent and the balance of buffer solution.
As a preferable technical scheme, the hyaluronic acid-collagen gel comprises 0.08wt% of hyaluronic acid, 0.03 wt% of collagen, 0.3 wt% of vitamin C, 0.008wt% of fructan, 0.02wt% of anti-allergy agent and the balance of buffer solution.
As a preferred technical scheme, the molecular weight of the hyaluronic acid is not more than 60000.
A preparation method of a water-light composition for removing acnes and shrinking pores comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5;
s2: adding hyaluronic acid to a 5 mmol/L phosphate buffer solution of pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ with vitamins, fructan and antiallergic agent, the mixed solution was dialyzed in ionized water and then freeze-dried to obtain powder.
Preferably, disodium hydrogen phosphate is used to adjust the PH of the aqueous solution in step S1.
Compared with the prior art, the invention has the following beneficial effects:
according to the invention, appropriate components of the water-light composition are selected, and the content of the components is strictly controlled, so that the water-light composition has a better effect in the directions of acne removing and hair collecting holes.
Detailed Description
The present invention is further described below by way of specific embodiments, but the present invention may be described by other embodiments without departing from the technical features of the invention, and therefore all changes within the scope of the present invention or the equivalent scope of the present invention are encompassed by the present invention.
Example 1
A water-based light composition for removing acne and shrinking pores comprises 0.06wt% of hyaluronic acid, 0.01wt% of collagen, 0.2 wt% of vitamin C, 0.004wt% of fructan, 0.01wt% of anti-allergy agent and the balance of buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ with vitamins, fructan and antiallergic agent, the mixed solution was dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
Example 2
A water-based light composition for removing acne and shrinking pores comprises 0.09wt% of hyaluronic acid, 0.04wt% of collagen, 0.5 wt% of vitamin C, 0.01wt% of fructan, 0.04wt% of anti-allergy agent and the balance of buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ if vitamins, fructan and anti-allergic agent are contained, the mixed solution is dialyzed in ionized water and then freeze-dried to obtain powder.
When used, the lyophilized powder was dissolved in phosphate buffer pH =7.4 to obtain an aqueous injection preparation.
Example 3
A water-based light composition for removing acne and shrinking pores comprises 0.08wt% of hyaluronic acid, 0.03 wt% of collagen, 0.3 wt% of vitamin C, 0.008wt% of fructan, 0.02wt% of anti-allergy agent and the balance of buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ with vitamins, fructan and antiallergic agent, the mixed solution was dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
Example 4
A water-based light composition for removing acne and shrinking pores comprises 0.1wt% of hyaluronic acid, 0.03 wt% of collagen, 0.3 wt% of vitamin C, 0.008wt% of fructan, 0.02wt% of anti-allergy agent and the balance of buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ with vitamins, fructan and antiallergic agent, the mixed solution was dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
Example 5
A water-based light composition for removing acne and shrinking pores comprises 0.05wt% of hyaluronic acid, 0.03 wt% of collagen, 0.3 wt% of vitamin C, 0.008wt% of fructan, 0.02wt% of anti-allergy agent and the balance of buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ with vitamins, fructan and antiallergic agent, the mixed solution was dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
Example 6
A water-based polishing composition for removing acnes and pores comprises 0.08wt% of hyaluronic acid, 0.008wt% of collagen, 0.3 wt% of vitamin C, 0.008wt% of fructan, 0.02wt% of an anti-allergic agent and the balance of a buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ if vitamins, fructan and anti-allergic agent are contained, the mixed solution is dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
Example 7
A water-based polishing composition for removing acnes and pores comprises 0.08wt% of hyaluronic acid, 0.05wt% of collagen, 0.3 wt% of vitamin C, 0.008wt% of fructan, 0.02wt% of an anti-allergic agent and the balance of a buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ with vitamins, fructan and antiallergic agent, the mixed solution was dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
Example 8
A water-based polishing composition for removing acnes and pores comprises 0.08wt% of hyaluronic acid, 0.03 wt% of collagen, 0.3 wt% of vitamin C, 0.02wt% of fructan, 0.02wt% of an anti-allergic agent and the balance of a buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ if vitamins, fructan and anti-allergic agent are contained, the mixed solution is dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
Example 9
A water-based polishing composition for removing acnes and pores comprises 0.08wt% of hyaluronic acid, 0.03 wt% of collagen, 0.1wt% of vitamin C, 0.002wt% of fructan, 0.02wt% of an anti-allergic agent and the balance of a buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ if vitamins, fructan and anti-allergic agent are contained, the mixed solution is dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
Example 10
A water-based polishing composition for removing acnes and pores comprises 0.08wt% of hyaluronic acid, 0.03 wt% of collagen, 0.5 wt% of vitamin C, 0.008wt% of fructan, 0.02wt% of an anti-allergic agent and the balance of a buffer solution.
The preparation method comprises the following steps:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5 with 5mol/L disodium hydrogen phosphate;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ with vitamins, fructan and antiallergic agent, the mixed solution was dialyzed in ionized water and then freeze-dried to obtain powder.
When in use, the freeze-dried powder is dissolved in phosphate buffer with pH =7.4 to obtain the water injection preparation.
The obtained examples 1 to 10 are water acupuncture compositions with different components, wherein the examples 1 to 3 have good effects on removing acne and shrinking pores, but the examples 4 to 10 have poor effects on removing acne and shrinking pores due to too high or too low component content.
It should be noted that, based on the above structural design, in order to solve the same technical problems, even if some insubstantial modifications or colorings are made on the present invention, the adopted technical solution is still the same as the present invention, and therefore, the technical solution should be within the protection scope of the present invention.
Claims (5)
1. The water-light composition for removing acnes and shrinking pores is characterized by comprising 0.06-0.09 wt% of hyaluronic acid, 0.01-0.04 wt% of collagen, 0.2-0.5 wt% of vitamin C, 0.004-0.01 wt% of fructan, 0.01-0.04 wt% of anti-sensitivity agent and the balance of buffer solution.
2. The hydro-optic composition for removing acnes and shrinking pores as claimed in claim 1, comprising hyaluronic acid 0.08wt%, collagen 0.03 wt%, vitamin C0.3 wt%, fructan 0.008wt%, anti-sensitization agent 0.02wt%, and buffer solution in balance.
3. The hydro-optic composition for removing acnes and shrinking pores and the preparation method thereof according to any one of claims 1-2, wherein the molecular weight of hyaluronic acid is not more than 60000.
4. The preparation method of the water-light composition for removing acnes and shrinking pores is characterized by comprising the following steps of:
s1: dissolving collagen in 0.2% (v/v) 5 mmol/L phosphate buffer solution, and adjusting pH to 5;
s2: adding hyaluronic acid to 5 mmol/L phosphate buffer solution with pH =7.4 to obtain a mixed solution;
s3: adding 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the mixed solution obtained in the step S2, and reacting at 30 ℃ for 30 min to obtain a new mixed solution, wherein the molar ratio of the 1-ethyl- (3-dimethylaminopropyl) carbodiimide hydrochloride to the hyaluronic acid is 1: 1;
s4: mixing the solution obtained in the step S3 with the solution obtained in the step S1, and reacting for 1h at 30 ℃;
s5: after reacting the solution obtained in step S4 for 20min at 30 ℃ with vitamins, fructan and antiallergic agent, the mixed solution was dialyzed in ionized water and then freeze-dried to obtain powder.
5. The method for preparing the aqueous composition for removing acne and pores according to claim 4, wherein disodium hydrogen phosphate is selected to adjust the pH value of the aqueous solution in the step S1.
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| CN109044948A (en) * | 2018-09-30 | 2018-12-21 | 白晋 | A kind of autologous collagen albumen water laser accunputure and preparation method thereof |
| KR102100646B1 (en) * | 2018-12-11 | 2020-05-15 | 김경호 | A cosmetic composition comprising stem cell such as rock samphire callus culture extract |
| CN112980001A (en) * | 2021-03-16 | 2021-06-18 | 杭州基智生物科技有限公司 | Collagen composite hyaluronic acid gel, extracellular matrix bionic material and preparation method |
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- 2022-03-31 CN CN202210333313.3A patent/CN114588071A/en active Pending
Patent Citations (4)
| Publication number | Priority date | Publication date | Assignee | Title |
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| CN108950012A (en) * | 2018-07-27 | 2018-12-07 | 珠海伊斯佳科技股份有限公司 | A method of it is detected based on skin quality related gene and formulates personalized skin care scheme |
| CN109044948A (en) * | 2018-09-30 | 2018-12-21 | 白晋 | A kind of autologous collagen albumen water laser accunputure and preparation method thereof |
| KR102100646B1 (en) * | 2018-12-11 | 2020-05-15 | 김경호 | A cosmetic composition comprising stem cell such as rock samphire callus culture extract |
| CN112980001A (en) * | 2021-03-16 | 2021-06-18 | 杭州基智生物科技有限公司 | Collagen composite hyaluronic acid gel, extracellular matrix bionic material and preparation method |
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