CN114573692B - 用于检测嗜铬粒蛋白a的免疫测定与抗体 - Google Patents
用于检测嗜铬粒蛋白a的免疫测定与抗体 Download PDFInfo
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- G01N33/582—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving labelled substances with fluorescent label
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EP14164809 | 2014-04-15 | ||
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CN201580019631.0A CN106461673A (zh) | 2014-04-15 | 2015-04-14 | 用于检测嗜铬粒蛋白a的免疫测定与抗体 |
PCT/EP2015/058045 WO2015158701A1 (fr) | 2014-04-15 | 2015-04-14 | Dosage immunologique et anticorps pour la détection de la chromogranine a |
CN202210181051.3A CN114573692B (zh) | 2014-04-15 | 2015-04-14 | 用于检测嗜铬粒蛋白a的免疫测定与抗体 |
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CN201580019631.0A Pending CN106461673A (zh) | 2014-04-15 | 2015-04-14 | 用于检测嗜铬粒蛋白a的免疫测定与抗体 |
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EP (2) | EP3633378A1 (fr) |
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CN (2) | CN114573692B (fr) |
BR (1) | BR112016021714A2 (fr) |
DK (1) | DK3132268T3 (fr) |
EA (1) | EA034364B1 (fr) |
ES (1) | ES2764225T3 (fr) |
WO (1) | WO2015158701A1 (fr) |
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BR112018067990A2 (pt) | 2016-03-09 | 2019-02-05 | Cezanne S A S | cromogranina a como um marcador para câncer de bexiga |
CN107090439B (zh) * | 2017-06-02 | 2020-05-05 | 福州迈新生物技术开发有限公司 | 一株分泌抗嗜铬素a单克隆抗体的杂交瘤细胞株及其应用 |
WO2019178562A1 (fr) * | 2018-03-16 | 2019-09-19 | Quest Diagnostics Investments Llc | Procédés de détection de chromogranine a par spectrométrie de masse |
CN109507432A (zh) * | 2018-11-14 | 2019-03-22 | 嘉兴行健生物科技有限公司 | 一种嗜铬蛋白a检测试剂及检测参考区间及检测方法 |
Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6632624B1 (en) * | 1998-05-14 | 2003-10-14 | Cis Bio International | Human chromogranin A (CgA) immunologic assay, antibodies, reagents and kits for said assay |
CN102520195A (zh) * | 2011-12-30 | 2012-06-27 | 天津市协和医药科技集团有限公司 | 一种嗜铬粒蛋白a化学发光免疫分析试剂盒及其制备方法 |
CN102869681A (zh) * | 2010-04-28 | 2013-01-09 | 欧罗诊断股份公司 | 嗜铬粒蛋白a的免疫测定法、抗体和试剂盒 |
Family Cites Families (10)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US4758522A (en) * | 1985-03-08 | 1988-07-19 | The Regents Of The University Of California | Immunoassay for human chromogranin A |
US6238877B1 (en) | 1997-11-05 | 2001-05-29 | Arup Institute | Method for prediction prostate cancer patients' resistance to hormonal treatment by measuring serum concentrations of chromogranin A |
US20050186642A1 (en) * | 2004-02-24 | 2005-08-25 | Biocare Medical, Inc. | Immunoassay reagents and methods of use thereof |
CN101377513A (zh) * | 2008-04-16 | 2009-03-04 | 北京科美东雅生物技术有限公司 | 嗜铬素a化学发光免疫分析定量测定试剂盒及其制备方法 |
CN102482343A (zh) * | 2009-06-16 | 2012-05-30 | B.R.A.H.M.S有限公司 | 过氧化物氧还蛋白4的诊断应用 |
US9671413B2 (en) | 2010-11-12 | 2017-06-06 | William Marsh Rice University | Prostate cancer point of care diagnostics |
JP5817838B2 (ja) * | 2011-11-02 | 2015-11-18 | ウシオ電機株式会社 | 蛍光標識抗体可変領域含有ポリペプチド複合体を用いた蛍光免疫測定方法 |
US8658166B2 (en) | 2011-11-08 | 2014-02-25 | Caldera Health Limited | Methods and materials for the diagnosis of prostate cancers |
US8632971B2 (en) | 2011-11-08 | 2014-01-21 | Caldera Health Limited | Methods and materials for determining the efficacy of prostate cancer therapies |
BR112018067990A2 (pt) * | 2016-03-09 | 2019-02-05 | Cezanne S A S | cromogranina a como um marcador para câncer de bexiga |
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Patent Citations (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US6632624B1 (en) * | 1998-05-14 | 2003-10-14 | Cis Bio International | Human chromogranin A (CgA) immunologic assay, antibodies, reagents and kits for said assay |
CN102869681A (zh) * | 2010-04-28 | 2013-01-09 | 欧罗诊断股份公司 | 嗜铬粒蛋白a的免疫测定法、抗体和试剂盒 |
CN102520195A (zh) * | 2011-12-30 | 2012-06-27 | 天津市协和医药科技集团有限公司 | 一种嗜铬粒蛋白a化学发光免疫分析试剂盒及其制备方法 |
Non-Patent Citations (2)
Title |
---|
Cell-specific Processing of Chromogranin A in Endocrine Cells of the Rat Stomach;Per Norlen等;The Journal of Histochemistry & Cytochemistry;第49卷(第1期);9-18 * |
嗜铬颗粒蛋白A研究进展;李瑞芳等;生命科学研究;第14卷(第4期);350-354 * |
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EP3132268A1 (fr) | 2017-02-22 |
US11719697B2 (en) | 2023-08-08 |
US20170122945A1 (en) | 2017-05-04 |
JP6812521B2 (ja) | 2021-01-13 |
CN106461673A (zh) | 2017-02-22 |
JP2017514128A (ja) | 2017-06-01 |
CN114573692A (zh) | 2022-06-03 |
EA201692071A1 (ru) | 2017-04-28 |
EA034364B1 (ru) | 2020-01-30 |
US20200348304A1 (en) | 2020-11-05 |
WO2015158701A1 (fr) | 2015-10-22 |
BR112016021714A2 (pt) | 2017-10-17 |
EP3633378A1 (fr) | 2020-04-08 |
JP6591442B2 (ja) | 2019-10-16 |
EP3132268B1 (fr) | 2019-10-16 |
DK3132268T3 (da) | 2020-01-02 |
US10648984B2 (en) | 2020-05-12 |
ES2764225T3 (es) | 2020-06-02 |
JP2020016660A (ja) | 2020-01-30 |
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