CN114568602A - Traditional Chinese medicine compound for improving growth performance and organism immunity of broiler chickens and preparation method and application thereof - Google Patents
Traditional Chinese medicine compound for improving growth performance and organism immunity of broiler chickens and preparation method and application thereof Download PDFInfo
- Publication number
- CN114568602A CN114568602A CN202210333839.1A CN202210333839A CN114568602A CN 114568602 A CN114568602 A CN 114568602A CN 202210333839 A CN202210333839 A CN 202210333839A CN 114568602 A CN114568602 A CN 114568602A
- Authority
- CN
- China
- Prior art keywords
- chinese medicine
- traditional chinese
- medicine compound
- broiler
- growth performance
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003814 drug Substances 0.000 title claims abstract description 108
- 150000001875 compounds Chemical class 0.000 title claims abstract description 94
- 241000287828 Gallus gallus Species 0.000 title claims abstract description 59
- 230000036039 immunity Effects 0.000 title claims abstract description 22
- 238000002360 preparation method Methods 0.000 title claims abstract description 10
- 241000404844 Callicarpa nudiflora Species 0.000 claims abstract description 12
- 241000196324 Embryophyta Species 0.000 claims abstract description 11
- 238000004519 manufacturing process Methods 0.000 claims abstract description 11
- 239000002689 soil Substances 0.000 claims abstract description 11
- 240000000691 Houttuynia cordata Species 0.000 claims abstract description 10
- 239000004071 soot Substances 0.000 claims abstract description 10
- 235000013719 Houttuynia cordata Nutrition 0.000 claims abstract description 9
- 240000002505 Pogostemon cablin Species 0.000 claims abstract description 9
- 235000011751 Pogostemon cablin Nutrition 0.000 claims abstract description 9
- 235000001855 Portulaca oleracea Nutrition 0.000 claims abstract description 9
- 235000006679 Mentha X verticillata Nutrition 0.000 claims abstract description 8
- 235000002899 Mentha suaveolens Nutrition 0.000 claims abstract description 8
- 235000001636 Mentha x rotundifolia Nutrition 0.000 claims abstract description 8
- 238000001035 drying Methods 0.000 claims abstract description 8
- 244000234609 Portulaca oleracea Species 0.000 claims abstract 2
- 238000007873 sieving Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 6
- 238000002156 mixing Methods 0.000 claims description 5
- 238000005303 weighing Methods 0.000 claims description 5
- 241001529821 Agastache Species 0.000 claims description 2
- 238000000643 oven drying Methods 0.000 claims description 2
- 238000010298 pulverizing process Methods 0.000 claims description 2
- UAJTZZNRJCKXJN-UHFFFAOYSA-M sodium;2-dodecoxy-2-oxoethanesulfonate Chemical compound [Na+].CCCCCCCCCCCCOC(=O)CS([O-])(=O)=O UAJTZZNRJCKXJN-UHFFFAOYSA-M 0.000 claims description 2
- 230000000694 effects Effects 0.000 abstract description 25
- 229940079593 drug Drugs 0.000 abstract description 17
- 241001465754 Metazoa Species 0.000 abstract description 11
- 239000003242 anti bacterial agent Substances 0.000 abstract description 10
- 229940088710 antibiotic agent Drugs 0.000 abstract description 10
- 230000001737 promoting effect Effects 0.000 abstract description 10
- 206010059866 Drug resistance Diseases 0.000 abstract description 9
- 230000008901 benefit Effects 0.000 abstract description 9
- 241000894006 Bacteria Species 0.000 abstract description 7
- 210000004369 blood Anatomy 0.000 abstract description 7
- 239000008280 blood Substances 0.000 abstract description 7
- 208000001848 dysentery Diseases 0.000 abstract description 7
- 206010061218 Inflammation Diseases 0.000 abstract description 6
- 238000009395 breeding Methods 0.000 abstract description 6
- 230000001488 breeding effect Effects 0.000 abstract description 6
- 230000004054 inflammatory process Effects 0.000 abstract description 6
- 206010012735 Diarrhoea Diseases 0.000 abstract description 5
- 238000001816 cooling Methods 0.000 abstract description 5
- 230000003467 diminishing effect Effects 0.000 abstract description 5
- 230000036737 immune function Effects 0.000 abstract description 5
- 210000001124 body fluid Anatomy 0.000 abstract description 4
- 239000010839 body fluid Substances 0.000 abstract description 4
- 230000002708 enhancing effect Effects 0.000 abstract description 4
- 230000007613 environmental effect Effects 0.000 abstract description 4
- 239000002671 adjuvant Substances 0.000 abstract description 2
- 239000013641 positive control Substances 0.000 description 27
- 239000000284 extract Substances 0.000 description 13
- 240000004534 Scutellaria baicalensis Species 0.000 description 10
- 235000017089 Scutellaria baicalensis Nutrition 0.000 description 10
- 210000000056 organ Anatomy 0.000 description 10
- 239000003963 antioxidant agent Substances 0.000 description 9
- 230000003078 antioxidant effect Effects 0.000 description 9
- 235000013330 chicken meat Nutrition 0.000 description 9
- 201000010099 disease Diseases 0.000 description 9
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 9
- 244000144977 poultry Species 0.000 description 9
- 235000013594 poultry meat Nutrition 0.000 description 9
- 210000000952 spleen Anatomy 0.000 description 9
- 108060003951 Immunoglobulin Proteins 0.000 description 8
- 102000018358 immunoglobulin Human genes 0.000 description 8
- 241000219304 Portulacaceae Species 0.000 description 7
- 239000010404 Scutellaria baicalensis extract Substances 0.000 description 7
- 210000002966 serum Anatomy 0.000 description 7
- 206010047700 Vomiting Diseases 0.000 description 6
- 210000001541 thymus gland Anatomy 0.000 description 6
- 230000008673 vomiting Effects 0.000 description 6
- 239000000463 material Substances 0.000 description 5
- 238000012360 testing method Methods 0.000 description 5
- 239000000796 flavoring agent Substances 0.000 description 4
- 235000019634 flavors Nutrition 0.000 description 4
- 210000004185 liver Anatomy 0.000 description 4
- 239000002994 raw material Substances 0.000 description 4
- 230000037396 body weight Effects 0.000 description 3
- 210000001669 bursa of fabricius Anatomy 0.000 description 3
- 230000006378 damage Effects 0.000 description 3
- 238000011161 development Methods 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 235000021050 feed intake Nutrition 0.000 description 3
- 230000001965 increasing effect Effects 0.000 description 3
- 208000015181 infectious disease Diseases 0.000 description 3
- 244000144972 livestock Species 0.000 description 3
- 210000004072 lung Anatomy 0.000 description 3
- 239000012528 membrane Substances 0.000 description 3
- 230000002829 reductive effect Effects 0.000 description 3
- 210000002784 stomach Anatomy 0.000 description 3
- 230000008961 swelling Effects 0.000 description 3
- YBJHBAHKTGYVGT-ZKWXMUAHSA-N (+)-Biotin Chemical compound N1C(=O)N[C@@H]2[C@H](CCCCC(=O)O)SC[C@@H]21 YBJHBAHKTGYVGT-ZKWXMUAHSA-N 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- 102000004190 Enzymes Human genes 0.000 description 2
- 108090000790 Enzymes Proteins 0.000 description 2
- 208000032843 Hemorrhage Diseases 0.000 description 2
- 241000282414 Homo sapiens Species 0.000 description 2
- XEEYBQQBJWHFJM-UHFFFAOYSA-N Iron Chemical compound [Fe] XEEYBQQBJWHFJM-UHFFFAOYSA-N 0.000 description 2
- DFPAKSUCGFBDDF-UHFFFAOYSA-N Nicotinamide Chemical compound NC(=O)C1=CC=CN=C1 DFPAKSUCGFBDDF-UHFFFAOYSA-N 0.000 description 2
- 239000000654 additive Substances 0.000 description 2
- 230000000996 additive effect Effects 0.000 description 2
- 150000001413 amino acids Chemical class 0.000 description 2
- 239000003674 animal food additive Substances 0.000 description 2
- 230000009286 beneficial effect Effects 0.000 description 2
- 230000000740 bleeding effect Effects 0.000 description 2
- 238000006243 chemical reaction Methods 0.000 description 2
- 230000003247 decreasing effect Effects 0.000 description 2
- 201000006549 dyspepsia Diseases 0.000 description 2
- OVBPIULPVIDEAO-LBPRGKRZSA-N folic acid Chemical compound C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)N[C@@H](CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-LBPRGKRZSA-N 0.000 description 2
- 235000013305 food Nutrition 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 230000006872 improvement Effects 0.000 description 2
- 230000002401 inhibitory effect Effects 0.000 description 2
- 230000000968 intestinal effect Effects 0.000 description 2
- 230000003859 lipid peroxidation Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 230000001937 non-anti-biotic effect Effects 0.000 description 2
- 235000016709 nutrition Nutrition 0.000 description 2
- 230000003647 oxidation Effects 0.000 description 2
- 238000007254 oxidation reaction Methods 0.000 description 2
- GHOKWGTUZJEAQD-UHFFFAOYSA-N pantothenic acid Chemical compound OCC(C)(C)C(O)C(=O)NCCC(O)=O GHOKWGTUZJEAQD-UHFFFAOYSA-N 0.000 description 2
- 239000000126 substance Substances 0.000 description 2
- 238000006467 substitution reaction Methods 0.000 description 2
- 231100000331 toxic Toxicity 0.000 description 2
- 230000002588 toxic effect Effects 0.000 description 2
- 239000011782 vitamin Substances 0.000 description 2
- 229940088594 vitamin Drugs 0.000 description 2
- 229930003231 vitamin Natural products 0.000 description 2
- 235000013343 vitamin Nutrition 0.000 description 2
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 description 2
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 description 1
- 206010067484 Adverse reaction Diseases 0.000 description 1
- 241000758794 Asarum Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 241001260012 Bursa Species 0.000 description 1
- 240000003690 Callicarpa japonica Species 0.000 description 1
- 235000017595 Callicarpa japonica Nutrition 0.000 description 1
- 206010007247 Carbuncle Diseases 0.000 description 1
- 208000003495 Coccidiosis Diseases 0.000 description 1
- RYGMFSIKBFXOCR-UHFFFAOYSA-N Copper Chemical compound [Cu] RYGMFSIKBFXOCR-UHFFFAOYSA-N 0.000 description 1
- 239000011665 D-biotin Substances 0.000 description 1
- 235000000638 D-biotin Nutrition 0.000 description 1
- QBDCOUHKEVYWLO-UHFFFAOYSA-N Decanoyl acetaldehyde Chemical compound CCCCCCCCCC(=O)CC=O QBDCOUHKEVYWLO-UHFFFAOYSA-N 0.000 description 1
- 241000588724 Escherichia coli Species 0.000 description 1
- 241000628997 Flos Species 0.000 description 1
- 208000005577 Gastroenteritis Diseases 0.000 description 1
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 description 1
- 208000034507 Haematemesis Diseases 0.000 description 1
- 235000013717 Houttuynia Nutrition 0.000 description 1
- 206010062717 Increased upper airway secretion Diseases 0.000 description 1
- 206010023076 Isosporiasis Diseases 0.000 description 1
- 231100000678 Mycotoxin Toxicity 0.000 description 1
- OVBPIULPVIDEAO-UHFFFAOYSA-N N-Pteroyl-L-glutaminsaeure Natural products C=1N=C2NC(N)=NC(=O)C2=NC=1CNC1=CC=C(C(=O)NC(CCC(O)=O)C(O)=O)C=C1 OVBPIULPVIDEAO-UHFFFAOYSA-N 0.000 description 1
- 208000004880 Polyuria Diseases 0.000 description 1
- BUGBHKTXTAQXES-UHFFFAOYSA-N Selenium Chemical compound [Se] BUGBHKTXTAQXES-UHFFFAOYSA-N 0.000 description 1
- DWAQJAXMDSEUJJ-UHFFFAOYSA-M Sodium bisulfite Chemical compound [Na+].OS([O-])=O DWAQJAXMDSEUJJ-UHFFFAOYSA-M 0.000 description 1
- 241000191967 Staphylococcus aureus Species 0.000 description 1
- 208000027418 Wounds and injury Diseases 0.000 description 1
- HCHKCACWOHOZIP-UHFFFAOYSA-N Zinc Chemical compound [Zn] HCHKCACWOHOZIP-UHFFFAOYSA-N 0.000 description 1
- 238000010521 absorption reaction Methods 0.000 description 1
- 230000002411 adverse Effects 0.000 description 1
- 230000006838 adverse reaction Effects 0.000 description 1
- 230000004520 agglutination Effects 0.000 description 1
- 235000001014 amino acid Nutrition 0.000 description 1
- 238000004458 analytical method Methods 0.000 description 1
- 238000003975 animal breeding Methods 0.000 description 1
- 235000021120 animal protein Nutrition 0.000 description 1
- 230000000844 anti-bacterial effect Effects 0.000 description 1
- 239000006030 antibiotic growth promoter Substances 0.000 description 1
- 239000000427 antigen Substances 0.000 description 1
- 102000036639 antigens Human genes 0.000 description 1
- 108091007433 antigens Proteins 0.000 description 1
- 230000001580 bacterial effect Effects 0.000 description 1
- 230000001420 bacteriolytic effect Effects 0.000 description 1
- 235000014590 basal diet Nutrition 0.000 description 1
- 230000003115 biocidal effect Effects 0.000 description 1
- 238000010241 blood sampling Methods 0.000 description 1
- 230000007969 cellular immunity Effects 0.000 description 1
- 230000008859 change Effects 0.000 description 1
- 239000003795 chemical substances by application Substances 0.000 description 1
- 229910052802 copper Inorganic materials 0.000 description 1
- 239000010949 copper Substances 0.000 description 1
- 235000021316 daily nutritional intake Nutrition 0.000 description 1
- 230000007547 defect Effects 0.000 description 1
- 230000007812 deficiency Effects 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 230000001079 digestive effect Effects 0.000 description 1
- 230000035619 diuresis Effects 0.000 description 1
- 239000003651 drinking water Substances 0.000 description 1
- 235000020188 drinking water Nutrition 0.000 description 1
- 238000005516 engineering process Methods 0.000 description 1
- 208000001780 epistaxis Diseases 0.000 description 1
- 238000000556 factor analysis Methods 0.000 description 1
- 229960000304 folic acid Drugs 0.000 description 1
- 235000019152 folic acid Nutrition 0.000 description 1
- 239000011724 folic acid Substances 0.000 description 1
- 244000053095 fungal pathogen Species 0.000 description 1
- 150000004676 glycans Chemical class 0.000 description 1
- 239000007952 growth promoter Substances 0.000 description 1
- 208000035861 hematochezia Diseases 0.000 description 1
- 230000023597 hemostasis Effects 0.000 description 1
- 238000007602 hot air drying Methods 0.000 description 1
- 230000004727 humoral immunity Effects 0.000 description 1
- 210000002865 immune cell Anatomy 0.000 description 1
- 230000001900 immune effect Effects 0.000 description 1
- 210000000987 immune system Anatomy 0.000 description 1
- 230000003053 immunization Effects 0.000 description 1
- 238000002649 immunization Methods 0.000 description 1
- 230000000091 immunopotentiator Effects 0.000 description 1
- 230000002757 inflammatory effect Effects 0.000 description 1
- 239000004615 ingredient Substances 0.000 description 1
- 208000014674 injury Diseases 0.000 description 1
- 229910052500 inorganic mineral Inorganic materials 0.000 description 1
- 208000011140 intestinal infectious disease Diseases 0.000 description 1
- 239000011630 iodine Substances 0.000 description 1
- 229910052740 iodine Inorganic materials 0.000 description 1
- 229910052742 iron Inorganic materials 0.000 description 1
- 210000002429 large intestine Anatomy 0.000 description 1
- 210000004698 lymphocyte Anatomy 0.000 description 1
- 210000002540 macrophage Anatomy 0.000 description 1
- WPBNNNQJVZRUHP-UHFFFAOYSA-L manganese(2+);methyl n-[[2-(methoxycarbonylcarbamothioylamino)phenyl]carbamothioyl]carbamate;n-[2-(sulfidocarbothioylamino)ethyl]carbamodithioate Chemical compound [Mn+2].[S-]C(=S)NCCNC([S-])=S.COC(=O)NC(=S)NC1=CC=CC=C1NC(=S)NC(=O)OC WPBNNNQJVZRUHP-UHFFFAOYSA-L 0.000 description 1
- 230000027939 micturition Effects 0.000 description 1
- 239000011707 mineral Substances 0.000 description 1
- 239000002636 mycotoxin Substances 0.000 description 1
- 229960003966 nicotinamide Drugs 0.000 description 1
- 235000005152 nicotinamide Nutrition 0.000 description 1
- 239000011570 nicotinamide Substances 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000017448 oviposition Effects 0.000 description 1
- 230000004792 oxidative damage Effects 0.000 description 1
- 230000000242 pagocytic effect Effects 0.000 description 1
- 230000002093 peripheral effect Effects 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 208000026435 phlegm Diseases 0.000 description 1
- 239000005017 polysaccharide Substances 0.000 description 1
- 229920001282 polysaccharide Polymers 0.000 description 1
- 239000000843 powder Substances 0.000 description 1
- 230000035935 pregnancy Effects 0.000 description 1
- 230000000069 prophylactic effect Effects 0.000 description 1
- 235000018102 proteins Nutrition 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 108090000623 proteins and genes Proteins 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
- 238000011160 research Methods 0.000 description 1
- 230000000630 rising effect Effects 0.000 description 1
- 210000003296 saliva Anatomy 0.000 description 1
- 238000012216 screening Methods 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 239000011669 selenium Substances 0.000 description 1
- 229910052711 selenium Inorganic materials 0.000 description 1
- 235000010267 sodium hydrogen sulphite Nutrition 0.000 description 1
- 239000007858 starting material Substances 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000005728 strengthening Methods 0.000 description 1
- 208000011580 syndromic disease Diseases 0.000 description 1
- 230000001988 toxicity Effects 0.000 description 1
- 231100000419 toxicity Toxicity 0.000 description 1
- 239000003053 toxin Substances 0.000 description 1
- 231100000765 toxin Toxicity 0.000 description 1
- 229940126680 traditional chinese medicines Drugs 0.000 description 1
- 229960005486 vaccine Drugs 0.000 description 1
- 210000003462 vein Anatomy 0.000 description 1
- 238000009423 ventilation Methods 0.000 description 1
- 239000000273 veterinary drug Substances 0.000 description 1
- 150000003722 vitamin derivatives Chemical class 0.000 description 1
- 238000010792 warming Methods 0.000 description 1
- 239000011701 zinc Substances 0.000 description 1
- 229910052725 zinc Inorganic materials 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K50/00—Feeding-stuffs specially adapted for particular animals
- A23K50/70—Feeding-stuffs specially adapted for particular animals for birds
- A23K50/75—Feeding-stuffs specially adapted for particular animals for birds for poultry
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K10/00—Animal feeding-stuffs
- A23K10/30—Animal feeding-stuffs from material of plant origin, e.g. roots, seeds or hay; from material of fungal origin, e.g. mushrooms
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23K—FODDER
- A23K20/00—Accessory food factors for animal feeding-stuffs
- A23K20/20—Inorganic substances, e.g. oligoelements
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K33/00—Medicinal preparations containing inorganic active ingredients
- A61K33/24—Heavy metals; Compounds thereof
- A61K33/26—Iron; Compounds thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/532—Agastache, e.g. giant hyssop
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/53—Lamiaceae or Labiatae (Mint family), e.g. thyme, rosemary or lavender
- A61K36/534—Mentha (mint)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/78—Saururaceae (Lizard's-tail family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K36/00—Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
- A61K36/18—Magnoliophyta (angiosperms)
- A61K36/185—Magnoliopsida (dicotyledons)
- A61K36/85—Verbenaceae (Verbena family)
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02P—CLIMATE CHANGE MITIGATION TECHNOLOGIES IN THE PRODUCTION OR PROCESSING OF GOODS
- Y02P60/00—Technologies relating to agriculture, livestock or agroalimentary industries
- Y02P60/80—Food processing, e.g. use of renewable energies or variable speed drives in handling, conveying or stacking
- Y02P60/87—Re-use of by-products of food processing for fodder production
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Natural Medicines & Medicinal Plants (AREA)
- Chemical & Material Sciences (AREA)
- Engineering & Computer Science (AREA)
- Medicinal Chemistry (AREA)
- Veterinary Medicine (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Biotechnology (AREA)
- Botany (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Alternative & Traditional Medicine (AREA)
- Microbiology (AREA)
- Medical Informatics (AREA)
- Polymers & Plastics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Animal Husbandry (AREA)
- Food Science & Technology (AREA)
- Immunology (AREA)
- Zoology (AREA)
- Birds (AREA)
- Inorganic Chemistry (AREA)
- Diabetes (AREA)
- Obesity (AREA)
- Hematology (AREA)
- Molecular Biology (AREA)
- Physiology (AREA)
- Communicable Diseases (AREA)
- Oncology (AREA)
- Medicines Containing Plant Substances (AREA)
- Fodder In General (AREA)
Abstract
The invention discloses a traditional Chinese medicine compound for improving growth performance and body immunity of broiler chickens and a preparation method and application thereof, and relates to the technical field of veterinary medicines. The traditional Chinese medicine compound comprises callicarpa nudiflora, purslane, houttuynia cordata, patchouli, mint, furnace soil and plant soot, and the mass ratio is 1.6-2.4: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.7-0.9: 0.7-0.9, the medicines are combined, the effects of resisting bacteria and diminishing inflammation, clearing heat and drying dampness, cooling blood and detoxifying, stopping dysentery and checking diarrhea, nourishing yin and promoting the production of body fluid and enhancing immunity are achieved, the growth of cultured animals is promoted, and the feed has the advantages of low cost, safety, no drug resistance, environmental friendliness, no residue and no antibiotics. The broiler chicken can be effectively improved to improve the production performance and the immune function of the broiler chicken, so that the production efficiency of broiler chicken breeding is effectively improved; the preparation is simple, other adjuvants are not needed, and the requirement of large-scale use in the breeding industry can be met.
Description
Technical Field
The invention relates to the technical field of veterinary medicines, and particularly relates to a traditional Chinese medicine compound for improving growth performance and body immunity of broiler chickens, and a preparation method and application thereof.
Background
Antibiotics are commonly used as a broad range of prophylactic agents and growth promoters for antibiotics in food animals and are the most cost effective means of maintaining feed efficiency and health in monogastric animals such as poultry by increasing growth rate, reducing mortality, and preventing disease. Due to the negative impact of synthetic drugs on poultry and consumer health and the rising cost of using drugs in poultry production, there is an urgent need to find functional replacement products. The european union has banned the use of antibiotics as growth promoters in 2006. The public announcement is also issued in rural areas of agriculture in China, and all varieties of growth-promoting drug feed additives except the traditional Chinese medicines are withdrawn from the 2020 by 1 month and 1 day.
The application of the traditional Chinese medicine in the feed or the additive thereof for preventing and treating the diseases of the cultured animals and promoting the growth is more and more extensive, and the non-resistant, green and healthy culture mode has wide development prospect. The traditional Chinese medicine contains various nutritional ingredients such as protein, amino acid, vitamin, polysaccharide and the like, can effectively improve the growth performance of animals and enhance the digestion and absorption functions; meanwhile, the compound immunopotentiator contains various effective immunocompetent components, promotes phagocytic function of macrophages and conversion rate of lymphocytes, is beneficial to inhibiting bacteria, and has obvious enhancement effect on cellular immunity and humoral immunity of organisms. Although the disease-resistant effect of the traditional Chinese medicine product developed by natural plants is hardly better than that of antibiotics and chemical synthetic medicines, the traditional Chinese medicine greatly reduces the risk of drug resistance and avoids the generation of super bacteria, and the traditional Chinese medicine in China also has the advantages of rich resources, low price, small toxic and side effects, no drug resistance, difficult residue and the like.
Therefore, a novel disease-resistant growth-promoting traditional Chinese medicine compound which is low in price, high in efficiency, safe, free of drug resistance, environment-friendly, free of residues and free of antibiotics is developed, and has an important application value in the animal breeding industry.
Disclosure of Invention
In order to overcome the defects of the feed and the additive thereof in the prior art, the invention aims to provide a traditional Chinese medicine compound for improving the growth performance and the body immunity of broiler chickens. The traditional Chinese medicine compound comprises callicarpa nudiflora, purslane, houttuynia cordata, patchouli, mint, furnace soil and plant soot, and the mass ratio is 1.6-2.4: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.7-0.9: 0.7-0.9, the medicines are combined, so that the effects of resisting bacteria and diminishing inflammation, clearing heat and drying dampness, cooling blood and detoxifying, stopping dysentery and checking diarrhea, nourishing yin and promoting the secretion of saliva or body fluid and enhancing immunity are achieved, the effect of promoting the growth of cultured animals is achieved, and the feed has the advantages of low cost, safety, no drug resistance, environmental friendliness, no residue and no antibiotics.
The invention also aims to provide a preparation method of the traditional Chinese medicine compound for improving the growth performance and the body immunity of the broiler chicken.
The invention also aims to provide application of the traditional Chinese medicine compound for improving the growth performance and the body immunity of the broiler chicken.
The purpose of the invention is realized by the following technical scheme:
the invention provides a traditional Chinese medicine compound for improving growth performance and organism immunity of broiler chickens, which comprises callicarpa nudiflora, purslane, houttuynia cordata, patchouli, mint, furnace soil and plant soot, wherein the mass ratio of the callicarpa nudiflora to the plant soot is 1.6-2.4: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.7-0.9: 0.7 to 0.9.
Preferably, the mass ratio is 2: 1: 1: 1: 1: 0.8: 0.8.
the preparation method of the traditional Chinese medicine compound for improving the growth performance and the body immunity of the broiler chicken comprises the following steps:
weighing Callicarpa nudiflora, herba Portulacae, herba Houttuyniae, herba Agastaches, herba Menthae, furnace soil, pulvis Fumi Carbonisatus, pulverizing, oven drying, sieving, mixing, and making into Chinese medicinal compound.
Preferably, the drying temperature is 60-70 ℃; further 60 ℃;
preferably, the sieving is to sieve the mixture by a sieve of 60-80 meshes; further sieving with 80 mesh sieve;
the traditional Chinese medicine compound for improving the growth performance and the body immunity of the broiler chickens is applied to preparing broiler chicken feed.
Preferably, the addition amount of the traditional Chinese medicine compound for improving the growth performance and the organism immunity of the broiler chickens in the broiler chicken feed is 1-5 g/kg; further 3-5 g/kg; further, the content of the amino acid was 3 g/kg.
The callicarpa nudiflora has the effects of detoxifying, resisting bacteria, diminishing inflammation, astringing for hemostasis, dissipating blood stasis and relieving swelling, and has an obvious relieving effect on inflammatory exudation and swelling, so that a good control effect on inflammatory reaction can be exerted, and in addition, the callicarpa nudiflora also has the effects of protecting the liver and resisting oxidation, so that adverse reactions of patients are reduced to a certain extent, and damages to organs such as the liver are reduced, which is one of the outstanding advantages of the medicine; the purslane enters large intestine and liver channels, has the effects of clearing away heat and toxic materials, promoting diuresis and cooling blood, is used for dysentery, carbuncle swelling, stranguria and the like caused by damp-heat or heat toxin, has the effects of inhibiting escherichia coli, dysentery bacillus, staphylococcus aureus and certain pathogenic fungi, promoting urination and strengthening intestinal peristalsis, and can be used for preventing and treating pullorum disease, bacterial enteritis, dyspepsia, coccidiosis and the like when being matched with other medicines; the heartleaf houttuynia herb enters lung and spleen channels, can regulate qi, invigorate spleen, eliminate dampness and reduce phlegm, and can be used for preventing and treating damp-heat dysentery of poultry, gastroenteritis, dyspepsia, pullorum disease and the like by being combined with other medicines. Researches show that the effect of adding 1%, 3% and 5% of houttuynia cordata stem and leaf powder in daily ration on the production benefit of the Baiyi black chickens in the later period of egg laying is better, the effect of replacing antibiotics to prevent and treat pullorum disease is better, and the synthetic houttuynine sodium bisulfite can improve the immune organ index of the broilers to different degrees and promote the development of immune organs. The mint is pungent and cool in flavor, enters lung and liver meridians, and has the effects of dispelling wind and heat and clearing head and eyes; patchouli is pungent in flavor and slightly warm in flavor, enters spleen, stomach and lung meridians, and has the effects of resolving turbidity with aromatics, regulating the middle warmer, relieving vomiting, relieving exterior syndrome and relieving summer-heat; the plant soot has been approved as a novel natural feed additive in 2020, can adsorb intestinal mycotoxin, inhibit bacterial reproduction and improve the digestive function of animals, is properly compatible with other medicaments, and is used for treating diseases such as wind-cold exogenous disease, spleen-stomach deficiency-cold, diarrhea, injury bleeding and the like of livestock and poultry; fulonggan, pungent and slightly warm in flavor, has the actions of warming middle energizer to stop bleeding, checking adverse rise of qi and stopping vomiting, and is commonly indicated for hematemesis, epistaxis, hematochezia, vomiting due to stomach cold, vomiting due to vomiting caused by cold of deficiency type, and vomiting of pregnancy.
The traditional Chinese medicine compound has the advantages of low cost, safety, no drug resistance, environmental protection, no residue and no antibiotic, and has the effects of resisting bacteria and diminishing inflammation, clearing heat and drying dampness, cooling blood and removing toxicity, stopping dysentery and checking diarrhea, nourishing yin and promoting the production of body fluid and enhancing immunity.
Repeated tests show that the most preferable scheme is that the weight ratio of callicarpa nudiflora, purslane, houttuynia cordata, patchouli, mint, furnace soil and plant soot is 2: 1: 1: 1: 1: 0.8: 0.8 the Wenchang chicken is tested by using the traditional Chinese medicine compound, and the results show that the performance of the broiler experimental group eating the feed added with the traditional Chinese medicine compound is better than or equal to that of the broiler control group eating the feed added with the positive control drug, namely the flos lonicerae and scutellaria baicalensis extract, in the aspects of average daily feed intake, average daily gain, total average weight, feed weight ratio, spleen index, bursa of fabricius index, thymus index, immunoglobulin IgG/IgM, antioxidant capacity and the like, and the traditional Chinese medicine compound does not contain antibiotics, can not cause drug resistance, can not expose a large amount of livestock and poultry and even human beings to infection risks caused by drug-resistant strains, and can not bring hidden troubles to food safety. And when the traditional Chinese medicine compound is added in 3g/kg (traditional Chinese medicine/feed), the traditional Chinese medicine compound is integrally superior to a broiler chicken control group of the feed of the positive control medicine, namely the wild flower scutellaria baicalensis extract, and a new thought can be provided for a non-antibiotic, green and healthy breeding mode.
Compared with the prior art, the invention has the following advantages and effects:
in the traditional Chinese medicine compound, the medicines are combined, so that the effects of resisting bacteria and diminishing inflammation, clearing heat and drying dampness, cooling blood and detoxifying, stopping dysentery and checking diarrhea, nourishing yin and promoting the production of body fluid and enhancing immunity are achieved, the traditional Chinese medicine compound has the effect of promoting the growth of cultured animals, has the advantages of low cost, safety, no drug resistance, environmental protection, no residue and no antibiotics, is superior to a positive control medicine, namely the wild flower scutellaria baicalensis extract on the whole, and provides a new thought for a non-antibiotic, green and healthy culture mode. In addition, the traditional Chinese medicine compound can effectively improve the broiler chickens, so that the production performance and the immune function of the broiler chickens are improved, and the production efficiency of broiler chicken breeding is effectively improved; the preparation is simple, other adjuvants are not needed, and the requirement of large-scale use in the breeding industry can be met.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto. The starting materials used in the examples of the present invention are conventionally purchased raw materials unless otherwise specified.
The extract of Scutellaria baicalensis Georgi used in the examples is from Tech technologies of Beijing, Taier, Inc., and is a new veterinary drug of three types disclosed in No. 2462 of Ministry of agriculture.
Example 1
1. Experimental Material
The traditional Chinese medicine compound composition comprises 20g of beautyberry, 10g of purslane, 10g of houttuynia cordata, 10g of patchouli, 10g of mint, 8g of furnace soil and 8g of plant soot, and the mass ratio is 2: 1: 1: 1: 1: 0.8: 0.8 weighing each raw material, crushing, drying in a hot air drying oven at 60 ℃, sieving with a 80-mesh sieve, uniformly mixing to obtain a traditional Chinese medicine compound, dividing into three groups, and uniformly mixing with the feed respectively to ensure that the addition amount of the traditional Chinese medicine compound in the feed is 1g/kg (traditional Chinese medicine compound/feed), 3g/kg (traditional Chinese medicine compound/feed) and 5g/kg (traditional Chinese medicine compound/feed). Positive control group (extract of Scutellaria baicalensis Georgi 0.5 g/kg): mixing the Scutellaria baicalensis Georgi extract with feed uniformly to make the mass ratio of 0.5g/kg (Scutellaria baicalensis Georgi extract/feed). Wherein the feed is the basic ration.
2. Experimental methods
Selecting 300 Wenchang chickens of 1 day age, dividing the Wenchang chickens into five groups (60 Wenchang chickens in each group, 3 repetitions in each group and 20 Wenchang chickens in each repetition), respectively taking blank control groups (only feeding the Wenchang chickens by using basic ration, the composition of the basic ration is shown in table 1), positive control groups (0.5 g/kg of extract of radix scutellariae of wild flowers), Chinese herbal compound groups 1(1g/kg), Chinese herbal compound groups 2(3g/kg) and Chinese herbal compound groups 3(5g/kg), weighing, calculating the average fasting weight of each group, respectively feeding for 28 days, and freely drinking water in the period to ensure good ventilation and proper temperature. After feeding for 28 days, recording feed intake, weighing on an empty stomach, and calculating average daily feed intake, Average Daily Gain (ADG), average body weight in the whole period and feed-weight ratio (F/G) of each group of test broilers; after the 28-day-old feeding test is finished, 6 chickens (2 chickens in each repeated group) are randomly extracted from each treatment group for wing vein blood sampling, a blood sample is centrifuged at 1200 Xg for 15 minutes, and a serum sample is collected and stored at-20 ℃; spleen, thymus and bursa of fabricius were collected, peripheral fat was removed and water was sucked off with filter paper, and then weighed and recorded, and immune organ index [ immune organ index (g/kg) ═ fresh weight (g) of immune organ/live weight (kg) ] was calculated. The content of serum immunoglobulin IgG and IgM was detected by enzyme-linked immunosorbent assay (ELASA) kit, which was purchased from Shanghai enzyme-linked Biotechnology Ltd. The kit is used for detecting the concentration or activity of MDA and T-AOC in serum, and is purchased from Nanjing to build a bioengineering institute.
TABLE 1 composition of basal diets
Note: 1. the formula of 5801 vitamins per kg comprises: vA：9 000 000IU，VD3：2 500 000IU，VE：22 000mg，VK3：4 000mg，VB1：2 000mg，VB2：6 000mg，VB6：4 000mg，VB12: 20.0mg, D-biotin 120.0mg, D-pantothenic acid 12000 mg, folic acid 1000 mg, nicotinamide 40000 mg. 2. The formula of each kg of poultry micro-mineral comprises: 100000 mg of iron, 8330 mg of copper, 92000 mg of manganese, 75000 mg of zinc, 417mg of iodine and 208mg of selenium. 3. The feed nutrition water average is calculated according to the raw material composition.
3. Results of the experiment
The statistical software SPSS 22.0 single-factor analysis of variance is used for carrying out difference significance analysis on test data among multiple groups of samples, all data are expressed as mean values +/-standard deviation, and the obtained test results are shown in tables 2-7.
TABLE 2 average daily gain of broiler chickens results (
n＝20)
| Group of | Average daily food intake (g) | Average daily gain (g) |
| Blank control group | 15.14±0.44c | 7.16±0.13c |
| Positive control group | 15.57±0.66bc | 7.54±0.26bc |
| Chinese medicine compound group 1 | 16.54±0.41ab | 7.85±0.22b |
| Chinese medicine compound group 2 | 16.16±0.64a | 7.96±0.13ab |
| Chinese medicine compound group 3 | 16.90±0.03a | 8.31±0.31a |
Note: the difference in the superscript letters on each column indicates significant difference (P < 0.05).
As can be seen from table 2, compared with the blank control group, the positive control group (0.5 g/kg of scutellaria baicalensis extract) has a tendency of increasing the average daily gain of broiler chickens, the traditional Chinese medicine compound group 1(1g/kg) and the traditional Chinese medicine compound group 2(3g/kg) can significantly increase the average daily gain of broiler chickens (P <0.05), and the traditional Chinese medicine compound group 3(5g/kg) can significantly increase the average daily gain of broiler chickens (P < 0.01). The Chinese herbal compound group 3(5g/kg) can obviously improve the average daily gain (P is less than 0.05) of the broiler compared with a positive control group (0.5 g/kg) and the daily gains of the Chinese herbal compound group 1(1g/kg) and the Chinese herbal compound group 2(3g/kg) are also better than the positive control group (0.5 g/kg) to a certain extent.
TABLE 3 average broiler weight results over the whole period
| Group of | Mean body weight (g) over time |
| Blank control group | 234.91±4.18c |
| Positive control group | 245.52±7.06bc |
| Chinese medicine compound group 1 | 253.98±6.03b |
| Chinese medicine compound group 2 | 257.63±4.21ab |
| Chinese medicine compound group 3 | 266.39±9.11a |
Note: the difference in the superscript letters on each column indicates significant difference (P < 0.05).
As can be seen from Table 3, compared with the blank control group, the traditional Chinese medicine compound group 1(1g/kg) and the traditional Chinese medicine compound group 2(3g/kg) can obviously improve the whole-period average weight of the 28-day-old broilers (P is less than 0.05); compared with a positive control group (0.5 g/kg of the scutellariae barbatae extract), the traditional Chinese medicine compound group 3(5g/kg) can obviously improve the average weight of the broiler chickens at the age of 28 days (P is less than 0.05), and has very obvious difference (P is less than 0.01) compared with a blank control group.
TABLE 4 broiler feed weight ratio results
| Group of | Material weight ratio (%) |
| Blank control group | 2.12±0.06 |
| Positive control group | 2.06±0.02 |
| Chinese medicine compound group 1 | 2.11±0.07 |
| Chinese medicine compound group 2 | 2.03±0.05 |
| Chinese medicine compound group 3 | 2.04±0.08 |
As can be seen from table 4, compared with the blank control group, the material weight ratios of the positive control group (0.5 g/kg of the scutellaria baicalensis extract) and the compound traditional Chinese medicine group are not significantly different and show a decreasing trend, wherein the material weight ratio of the compound traditional Chinese medicine group 2(3g/kg) is decreased more, which indicates that the compound traditional Chinese medicine group 2(3g/kg) can promote the feed conversion rate of broiler chickens to a certain extent, and the effect of the compound traditional Chinese medicine group is better than that of the positive control group (0.5 g/kg of the scutellaria baicalensis extract).
TABLE 5 broiler immune organ index results
| Group of | Thymus index (g/kg) | Bursa index (g/kg) | Spleen index (g/kg) |
| Blank control group | 0.43±0.14 | 0.43±0.08 | 0.24±0.02 |
| Positive control group | 0.55±0.16 | 0.47±0.10 | 0.26±0.05 |
| Chinese medicine compound group 1 | 0.49±0.19 | 0.51±0.10 | 0.26±0.03 |
| Chinese medicine compound group 2 | 0.59±0.13 | 0.53±0.13 | 0.26±0.02 |
| Chinese medicine compound group 3 | 0.60±0.05 | 0.46±0.09 | 0.25±0.05 |
Spleen, thymus and bursa of fabricius are organs which exert immune effect on poultry organisms, and the immune index of the organs can be detected to preliminarily measure the immune state of the organisms and the development condition of an immune system. As can be seen from Table 5, compared with the blank control group, the positive control group (0.5 g/kg of the extract of Scutellaria baicalensis Georgi) and the Chinese herbal compound groups all have certain improvements in thymus index, bursal index and spleen index, which belong to the increase in the normal range, reflect the enhancement of animal immune function to a certain extent, and are beneficial to promoting the organism to generate immune cells and improving the level of vaccine antibodies.
TABLE 6 serum immunoglobulin (IgG, IgM) results
| Group of | IgG(mg/L) | IgM(mg/L) |
| Blank control group | 2426.19±40.26c | 824.68±25.69b |
| Positive control group | 2639.52±65.78b | 851.98±30.39b |
| Chinese medicine compound group 1 | 2686.43±31.65b | 829.68±34.51b |
| Chinese medicine compound group 2 | 2697.38±24.95b | 849.84±28.83b |
| Chinese medicine compound group 3 | 2901.90±74.56a | 979.05±43.99a |
Note: the difference in the superscript letters on each column indicates significant difference (P < 0.05).
Immunoglobulin is an animal protein with antibody activity, is converted into an antibody after antigen stimulation, is the same as an immune organ index, and is an important index for measuring the immune function of animals. Wherein IgG is the highest content of immunoglobulin in serum, accounts for 75 percent, and is the main antibody generated by animals after natural infection and artificial active immunization; IgM is a high-performance antibody, the content of which is only second to that of IgG, and accounts for 10-12% of total serum Ig, and the IgM has strong bactericidal, bacteriolytic and agglutination effects. As can be seen from Table 6, compared with the blank control group, the positive control group (0.5 g/kg of Scutellaria baicalensis Georgi extract) has the advantages that the immunoglobulin IgG is remarkably increased, and the IgM is improved to a certain extent, so that the positive control group (0.5 g/kg of Scutellaria baicalensis Georgi extract) can improve the immunity of the broiler chicken. Observing the traditional Chinese medicine compound groups, the traditional Chinese medicine compound groups 1 and 2 can obviously improve the IgG level of the broiler chickens, the traditional Chinese medicine compound group 3 can greatly improve the IgG level of the broiler chickens, and similar results are reflected on immunoglobulin IgM, so that the traditional Chinese medicine compound groups can improve the immune function of organisms as same as a positive control group, and the traditional Chinese medicine compound groups have certain dosage tolerance, and the larger the dosage is, the more obvious the improvement effect is. In combination, IgG and IgM were equally or more quantitatively identical to or superior to that of the positive control group (Scutellaria baicalensis Georgi extract 0.5g/kg) starting from the traditional Chinese medicine compound group 2(3 g/kg).
TABLE 7 serum antioxidant index (T-AOC, MDA) results
| Group of | T-AOC(U/mL) | MDA(μmol/L) |
| Blank control group | 6.71±0.40c | 6.55±0.54a |
| Positive control group | 7.14±0.29bc | 5.86±0.62ab |
| Chinese medicine compound group 1 | 7.55±0.10ab | 5.95±0.64ab |
| Chinese medicinal compound group 2 | 7.32±0.15abc | 5.20±0.47b |
| Chinese medicine compound group 3 | 7.86±0.54a | 5.09±0.70b |
Note: differences in the superscript letter on each column indicate significant differences (P < 0.05).
T-AOC is used for evaluating the total antioxidant level formed by antioxidant substances, antioxidant enzymes and the like of the body; MDA is one of the most important products of membrane lipid peroxidation, and the damage of the membrane can be aggravated by the generation of MDA, and the degree of membrane lipid peroxidation is commonly known by the MDA. As shown in Table 7, compared with the blank control group, the total antioxidant capacity of each group of the Chinese herbal compound is higher than that of the blank control group, and the total antioxidant capacity of the group 3(5g/kg) of the Chinese herbal compound is significantly higher than that of the positive control group (P < 0.05). MDA of a positive control group (0.5 g/kg of the extract of the scutellaria baicalensis of the mountain flower) has a tendency of reducing, and the positive control group can reduce the oxidative damage of the oxidized oil to the organism or enhance the endogenous antioxidant capacity of the organism to a certain extent; MDA of each group of the traditional Chinese medicine compound also shows a descending trend, wherein the traditional Chinese medicine compound group 2(3g/kg) and the traditional Chinese medicine compound group 3(5g/kg) are remarkably reduced compared with a blank control group (P is less than 0.05). The results of T-AOC and MDA jointly show that the oxidation resistance of the traditional Chinese medicine compound group 2(3g/kg) and the traditional Chinese medicine compound group 3(5g/kg) is equal to or better than that of a positive control group (0.5 g/kg of the extract of the scutellaria baicalensis of the mountain flower).
In conclusion, the performance of the broiler experimental group eating the feed added with the traditional Chinese medicine compound in the aspects of average daily gain, total-period average body weight, material-to-weight ratio, spleen index, bursal index, thymus index, immunoglobulin IgG/IgM, antioxidant capacity and the like is superior to or equal to that of the broiler control group eating the feed added with the positive medicine (0.5 g/kg of the scutellaria baicalensis extract), and the traditional Chinese medicine compound does not contain antibiotics, does not cause drug resistance, does not expose a large amount of livestock and poultry and even human beings to infection danger caused by drug-resistant strains, the traditional Chinese medicine compound group 2(3g/kg) and the traditional Chinese medicine compound group 3(5g/kg) are equal to or superior to the positive control drug, namely the extract of the radix scutellariae barbatae, on the whole, so that more choices can be provided for clinical medication, and a new thought is provided for a non-resistance, green and healthy breeding mode.
In addition, through multiple experiments of the inventor, the inventor finds that the raw materials of the traditional Chinese medicine compound are weighed according to 20g of callicarpa nudiflora, 10g of purslane, 10g of houttuynia cordata, 10g of pogostemon cablin, 10g of mint, 8g of furnace soil and 8g of plant soot, and under the condition that the total compound dosage is the same, the influence of small change of the dosage of each medicine on the experimental result is very small, so the embodiment of the invention is described in detail as the experimental results of 16-24 g of callicarpa nudiflora, 8-12 g of purslane, 8-12 g of houttuynia cordata, 8-12 g of pogostemon cablin, 8-12 g of furnace soil, 7-9 g of furnace soil and 7-9 g of plant soot, and through dosage screening, the traditional Chinese medicine compound is considered to be uniformly mixed with feed according to 3g/kg, and the cost ratio of the medicines can be exerted to the maximum.
The above embodiments are preferred embodiments of the present invention, but the present invention is not limited to the above embodiments, and any other changes, modifications, substitutions, combinations, and simplifications which do not depart from the spirit and principle of the present invention should be construed as equivalents thereof, and all such changes, modifications, substitutions, combinations, and simplifications are intended to be included in the scope of the present invention.
Claims (9)
1. The traditional Chinese medicine compound for improving growth performance and organism immunity of broiler chickens is characterized by comprising callicarpa nudiflora, purslane, houttuynia cordata, patchouli, mint, furnace soil and plant soot in a mass ratio of 1.6-2.4: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.8-1.2: 0.7-0.9: 0.7 to 0.9.
2. The compound traditional Chinese medicine according to claim 1, which is characterized in that:
the mass ratio is 2: 1: 1: 1: 1: 0.8: 0.8.
3. the preparation method of the traditional Chinese medicine compound for improving the growth performance and the body immunity of the broiler chicken in the claim 1 or 2 is characterized by comprising the following steps:
weighing Callicarpa nudiflora, herba Portulacae, herba Houttuyniae, herba Agastaches, herba Menthae, furnace soil, pulvis Fumi Carbonisatus, pulverizing, oven drying, sieving, mixing, and making into Chinese medicinal compound.
4. The production method according to claim 3, characterized in that:
the drying temperature is 60-70 ℃;
the sieving is to sieve the mixture by a sieve of 60-80 meshes.
5. The production method according to claim 3 or 4, characterized in that:
the drying temperature is 60 ℃;
the sieving is 80-mesh sieving.
6. The application of the Chinese herbal compound for improving the growth performance and the body immunity of the broiler chicken in the preparation of broiler chicken feed in the claim 1 or 2.
7. Use according to claim 6, characterized in that:
the addition amount of the traditional Chinese medicine compound for improving the growth performance and the organism immunity of the broiler chickens in the broiler chicken feed is 1-5 g/kg.
8. Use according to claim 6 or 7, characterized in that:
the addition amount of the traditional Chinese medicine compound for improving the growth performance and the organism immunity of the broiler chickens in the broiler chicken feed is 3-5 g/kg.
9. Use according to claim 8, characterized in that:
the addition amount of the traditional Chinese medicine compound for improving the growth performance and the body immunity of the broiler chickens in the broiler chicken feed is 3 g/kg.
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210333839.1A CN114568602B (en) | 2022-03-31 | 2022-03-31 | Traditional Chinese medicine compound for improving growth performance and organism immunity of broiler chickens and preparation method and application thereof |
Applications Claiming Priority (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| CN202210333839.1A CN114568602B (en) | 2022-03-31 | 2022-03-31 | Traditional Chinese medicine compound for improving growth performance and organism immunity of broiler chickens and preparation method and application thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| CN114568602A true CN114568602A (en) | 2022-06-03 |
| CN114568602B CN114568602B (en) | 2023-10-20 |
Family
ID=81778684
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| CN202210333839.1A Active CN114568602B (en) | 2022-03-31 | 2022-03-31 | Traditional Chinese medicine compound for improving growth performance and organism immunity of broiler chickens and preparation method and application thereof |
Country Status (1)
| Country | Link |
|---|---|
| CN (1) | CN114568602B (en) |
Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116808109A (en) * | 2023-07-07 | 2023-09-29 | 华南农业大学 | Traditional Chinese medicine compound for resisting chronic heat stress of broiler chickens and preparation and application thereof |
| CN116870091A (en) * | 2023-07-13 | 2023-10-13 | 华南农业大学 | Traditional Chinese medicine compound for resisting LPS stress of broiler chickens as well as preparation and application thereof |
Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404737A (en) * | 2013-08-20 | 2013-11-27 | 张黎明 | Composite chicken feed additive as well as preparation and application methods thereof |
| CN104012801A (en) * | 2014-06-11 | 2014-09-03 | 湖南中医药大学 | Poultry feed containing callicarpa nudiflora and preparing method of poultry feed |
| CN104187170A (en) * | 2014-09-12 | 2014-12-10 | 安徽农业大学 | Green tea composite chicken feed additive capable of enhancing immunity of chickens |
| CN106360040A (en) * | 2016-08-24 | 2017-02-01 | 广东海大集团股份有限公司畜牧水产研究中心 | Composite Chinese herbal medicine and probiotics feed additive for improving growth property and immuno-functions of broiler chicken |
| CN107568491A (en) * | 2017-09-21 | 2018-01-12 | 德阳齐远生态农业有限公司 | A kind of chicken feed for adding medicinal material and preparation method thereof |
| CN107889963A (en) * | 2017-11-21 | 2018-04-10 | 安徽农业大学 | A kind of Chinese herbal medicine complexing agent for producing minty note chicken |
| CN109123174A (en) * | 2018-07-25 | 2019-01-04 | 广州格雷特生物科技有限公司 | Containing callicarpa nudiflora poultry premixed feed and its preparation method and application |
| CN110521875A (en) * | 2019-08-28 | 2019-12-03 | 福建省百草霜生物科技有限公司 | A kind of broiler fodder adding Plant Soot |
| AU2020101290A4 (en) * | 2020-07-08 | 2020-08-13 | Liaoning Dingfeng Kerun Feed Co., Ltd | Chinese Medicinal Feed Additive |
| CN112807348A (en) * | 2021-01-07 | 2021-05-18 | 华南农业大学 | Traditional Chinese medicine compound for resisting diseases and promoting growth as well as preparation and application thereof |
| CN113876865A (en) * | 2021-11-02 | 2022-01-04 | 江西普正制药股份有限公司 | Fermented traditional Chinese medicine preparation for preventing and treating respiratory diseases of livestock and poultry and preparation method thereof |
-
2022
- 2022-03-31 CN CN202210333839.1A patent/CN114568602B/en active Active
Patent Citations (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN103404737A (en) * | 2013-08-20 | 2013-11-27 | 张黎明 | Composite chicken feed additive as well as preparation and application methods thereof |
| CN104012801A (en) * | 2014-06-11 | 2014-09-03 | 湖南中医药大学 | Poultry feed containing callicarpa nudiflora and preparing method of poultry feed |
| CN104187170A (en) * | 2014-09-12 | 2014-12-10 | 安徽农业大学 | Green tea composite chicken feed additive capable of enhancing immunity of chickens |
| CN106360040A (en) * | 2016-08-24 | 2017-02-01 | 广东海大集团股份有限公司畜牧水产研究中心 | Composite Chinese herbal medicine and probiotics feed additive for improving growth property and immuno-functions of broiler chicken |
| CN107568491A (en) * | 2017-09-21 | 2018-01-12 | 德阳齐远生态农业有限公司 | A kind of chicken feed for adding medicinal material and preparation method thereof |
| CN107889963A (en) * | 2017-11-21 | 2018-04-10 | 安徽农业大学 | A kind of Chinese herbal medicine complexing agent for producing minty note chicken |
| CN109123174A (en) * | 2018-07-25 | 2019-01-04 | 广州格雷特生物科技有限公司 | Containing callicarpa nudiflora poultry premixed feed and its preparation method and application |
| CN110521875A (en) * | 2019-08-28 | 2019-12-03 | 福建省百草霜生物科技有限公司 | A kind of broiler fodder adding Plant Soot |
| AU2020101290A4 (en) * | 2020-07-08 | 2020-08-13 | Liaoning Dingfeng Kerun Feed Co., Ltd | Chinese Medicinal Feed Additive |
| CN112807348A (en) * | 2021-01-07 | 2021-05-18 | 华南农业大学 | Traditional Chinese medicine compound for resisting diseases and promoting growth as well as preparation and application thereof |
| CN113876865A (en) * | 2021-11-02 | 2022-01-04 | 江西普正制药股份有限公司 | Fermented traditional Chinese medicine preparation for preventing and treating respiratory diseases of livestock and poultry and preparation method thereof |
Non-Patent Citations (1)
| Title |
|---|
| 孙齐英: "超微粉中草药添加剂对热应激江汉土鸡免疫器官组织形态学的影响", 《安徽农业科学》, vol. 41, no. 03, pages 1112 - 1113 * |
Cited By (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN116808109A (en) * | 2023-07-07 | 2023-09-29 | 华南农业大学 | Traditional Chinese medicine compound for resisting chronic heat stress of broiler chickens and preparation and application thereof |
| CN116808109B (en) * | 2023-07-07 | 2024-03-12 | 华南农业大学 | Traditional Chinese medicine compound for resisting chronic heat stress of broiler chickens and preparation and application thereof |
| CN116870091A (en) * | 2023-07-13 | 2023-10-13 | 华南农业大学 | Traditional Chinese medicine compound for resisting LPS stress of broiler chickens as well as preparation and application thereof |
| CN116870091B (en) * | 2023-07-13 | 2024-04-12 | 华南农业大学 | Traditional Chinese medicine compound for resisting LPS stress of broiler chickens as well as preparation and application thereof |
Also Published As
| Publication number | Publication date |
|---|---|
| CN114568602B (en) | 2023-10-20 |
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| Rahimi et al. | Effect of the three herbal extracts on growth performance, immune system, blood factors and intestinal selected bacterial population in broiler chickens | |
| EP0761103B1 (en) | Feed containing crude drug | |
| CN112568324B (en) | Composite probiotics fermented traditional Chinese medicine feed additive and preparation method and application thereof | |
| CN104161181B (en) | The feed additive of a kind of anti-pig bacterial disease, preparation method and application | |
| CN102657292A (en) | Compound feed for 0-21-days-old broiler chicken and preparation method of compound feed | |
| CN102813064A (en) | Plant extract feed additive for piglets | |
| CN105767532A (en) | Compound plant essential oil-type feed additive capable of replacing antibiotics | |
| CN114568602B (en) | Traditional Chinese medicine compound for improving growth performance and organism immunity of broiler chickens and preparation method and application thereof | |
| CN102805267B (en) | Feed for feeding broiler | |
| CN102669496A (en) | Montmorillonite-containing 1-21-days-old broiler chicken compound feed and preparation method thereof | |
| KR20110059408A (en) | A process for producing feedstuff additives comprising natural herbs and having a preventing activity of calf's diarrhea | |
| CN104738305A (en) | Preparation method and application of buckwheat active peptides | |
| CN112807348B (en) | Disease-resistant and growth-promoting traditional Chinese medicine compound, and preparation and application thereof | |
| KR102012751B1 (en) | Platycodon grandiflorum extract animal feed additive and animal feed | |
| Antara et al. | Effects of Moringa oleifera leaf and probiotics mixed fermented extract on the egg production and cholesterol contents in egg of laying hens | |
| CN112426501B (en) | Traditional Chinese medicine microecological preparation for promoting growth and preventing diarrhea of calves and preparation method thereof | |
| KR101087269B1 (en) | Process for producing feedstuff additives with a bacteria inhibiting activity comprising fermented wormwoods and process for obtaining eggs using the said feedsutff | |
| CN112514995A (en) | Suckling pig immune milk powder rich in probiotics and prebiotics and preparation method thereof | |
| Elbaz et al. | Effectiveness of probiotics and clove essential oils in improving growth performance, immuno-antioxidant status, ileum morphometric, and microbial community structure for heat-stressed broilers | |
| CN105395674B (en) | A kind of Traditional Chinese medicine probiotic compound formulation and preparation method thereof for preventing and treating fowl gland ventriculitis | |
| CN112293604A (en) | Chinese herbal medicine additive for feeding laying hens and feeding method thereof | |
| Mao et al. | Effect of fermented dandelion on productive performance, meat quality, immune function, and intestinal microbiota of broiler chickens | |
| CN102987090B (en) | Pig-breeding method for rapidly fattening | |
| CN113841802A (en) | Chinese herbal medicine functional anti-substitution composition containing garlic crude extract for baby rabbits as well as preparation method and application of Chinese herbal medicine functional anti-substitution composition | |
| CN115212239B (en) | Composite immunopotentiator for poultry and preparation method thereof |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| PB01 | Publication | ||
| PB01 | Publication | ||
| SE01 | Entry into force of request for substantive examination | ||
| SE01 | Entry into force of request for substantive examination | ||
| GR01 | Patent grant | ||
| GR01 | Patent grant | ||
| TR01 | Transfer of patent right |
Effective date of registration: 20240605 Address after: Room 201, building B, No.5, Industrial Avenue, Xishan village, Hualong Town, Panyu District, Guangzhou City, Guangdong Province 510000 Patentee after: GUANGDONG WEI LAI BIOTECHNOLOGY CO.,LTD. Country or region after: China Address before: 510642 No. five, 483 mountain road, Guangzhou, Guangdong, Tianhe District Patentee before: SOUTH CHINA AGRICULTURAL University Country or region before: China |
|
| TR01 | Transfer of patent right |