CN113841802A

CN113841802A - Chinese herbal medicine functional anti-substitution composition containing garlic crude extract for baby rabbits as well as preparation method and application of Chinese herbal medicine functional anti-substitution composition

Info

Publication number: CN113841802A
Application number: CN202111094134.0A
Authority: CN
Inventors: 张吉鹍; 宗敏玲
Original assignee: Jiangxi Zhongchengren Medicine Co ltd
Current assignee: Jiangxi Zhongchengren Medicine Co ltd
Priority date: 2021-09-17
Filing date: 2021-09-17
Publication date: 2021-12-28

Abstract

The invention discloses a garlic crude extract-containing Chinese herbal medicine functional substitution antibody composition for newborn rabbits, and a preparation method and application thereof, wherein the garlic crude extract-containing Chinese herbal medicine functional substitution antibody composition is prepared by uniformly mixing the following crude extracts of medicinal and edible Chinese herbal medicines in parts by mass: 280-300 parts of garlic crude extract, 200-230 parts of astragalus polysaccharide, 140-160 parts of myrobalan crude extract, 150-170 parts of acanthopanax crude extract, 170-180 parts of hawthorn crude extract, 160-170 parts of poplar flower crude extract, 130-140 parts of dandelion crude extract, 130-150 parts of wild chrysanthemum crude extract, 170-190 parts of houttuynia cordata crude extract, 140-150 parts of portulaca oleracea crude extract and 130-160 parts of liquorice crude extract. The Chinese herbal medicine functional substitution composition provided by the invention is green, safe, environment-friendly and obvious in effect, and the whole health care scheme of the Chinese herbal medicine functional substitution composition replaces chemical synthetic drugs and antibiotics in the feed of the young rabbits, conditions the sub-health state and the visceral functions of the young rabbits, reduces morbidity, creates value for clients, and provides technical support for sustainable development of meat rabbits.

Description

Chinese herbal medicine functional anti-substitution composition containing garlic crude extract for baby rabbits as well as preparation method and application of Chinese herbal medicine functional anti-substitution composition

Technical Field

The invention relates to the technical field of Chinese herbal medicines, in particular to a natural Chinese herbal medicine crude extract feed additive for health care in the field of animal feed, and specifically relates to a Chinese herbal medicine functional anti-substitution composition for baby rabbits containing garlic crude extract, and also relates to a baby rabbit compound premix feed and a complete feed containing the Chinese herbal medicine functional anti-substitution composition.

Background

Along with the rapid development of the rabbit industry, the rabbit disease problem is increasingly prominent, and the healthy development of the rabbit industry is greatly hindered. The weaned young rabbit grows and develops fast, but because the digestive system and immune system of the weaned young rabbit are not developed completely, weaning stress, allergic intestinal tract injury caused by daily ration antigens (such as soybean antigenic proteins like glycinin, beta-mixed glycinin and the like) and lack of nutritional active substances which exist in breast milk and promote the growth and development of the body of the young rabbit, particularly digestive tract cells, such as peptide growth factors like epidermal growth factor, L-glutamine and polyamine substances like spermine, spermidine, putrescine and the like, one or more of the factors can reduce the resistance of the young rabbit, so that Escherichia coli pathogenic bacteria and the like which are in a normal state in the digestive tract of the young rabbit show pathogenicity, and intestinal endogenous infection (such as diarrhea) is caused to cause death of the young rabbit.

The survival rate of the fattening baby rabbits has important influence on the production performance of the fattening rabbits and the economic benefit of rabbit meat production, and diarrhea (commonly called diarrhea) is a main factor influencing the survival rate of the fattening baby rabbits. It has been reported that more than 70% of a 20% mortality population is due to diarrhea. In some rabbit farms with poor feeding management, the death rate of weaned newborn rabbits reaches 50% -70%, wherein more than 80% of newborn rabbits die due to enteritis and diarrhea, and newborn rabbits within 1 month of weaning age are frequently sent.

In traditional production, antibiotics, chemical synthetic drugs and other medicines are often used for controlling common diseases of young livestock and poultries including young rabbits and diarrhea. According to ' notice No. 194 of the department of agricultural rural area ' issued in 2019, 7 and 9 days in 2019 ', feed manufacturers stop producing commercial feeds containing growth-promoting drug feed additives except traditional Chinese medicines in 7, 1 and 1 days in 2020 in China. This marks the most strict antibiotic forbidding, limiting and non-antibiotic policies in the beginning implementation history of animal husbandry in China. With the comprehensive implementation of feed banning, the novel anti-feed additive becomes a hot spot of research at home and abroad. The natural Chinese herbal medicine feed additive which can be directly added into the feed and used for the health care of livestock, poultry and aquatic animals, preventing enteritis and diarrhea, reducing the death rate and safely and effectively replacing the function of antibiotics in the feed is screened out from the medicinal and edible Chinese herbal medicines which can be used as the raw materials of the feed, is one of the hot spots of the current research, and has wide market prospect.

The medicinal and edible Chinese herbal medicine which can be used as a feed raw material is a natural plant, contains various effective components including polysaccharide, alkaloid, glycosides and the like, has comprehensive functions, high safety, small toxic and side effects, low possibility of generating drug resistance, low or no residue, abundant resources, wide sources and low cost, and has double effects of nutrition and medicine. The medicinal and edible Chinese herbal medicine feed additive which can be used as a feed raw material is a natural plant feed additive, maintains the natural state and the biological activity of various component structures, and is green, safe and environment-friendly. The garlic crude extract which has the functions of clearing away heat and toxic materials, tonifying qi, enhancing immunologic function, resisting stress and viruses, astragalus mongholicus with broad-spectrum antibiosis, stopping diarrhea of young animals, resisting coccidiosis, preventing mildew and expelling parasites, promoting appetite, improving meat quality, detoxifying and removing toxicity, enhancing immunity and strengthening body, inhibiting the nutritional activity of viruses, relieving immunosuppression, improving immunity, enhancing animal constitution, maintaining intestinal health, improving feeding environment, promoting feed digestion and absorption, improving production performance and having better growth promoting effect than antibiotics is applied in combination, so that the substances are mutually promoted and play the integral synergistic function and action, which is incomparable with chemically synthesized medicaments. However, no technical or patent reports on this aspect have been found so far.

Disclosure of Invention

The invention aims to solve the problems that: the functional substitution composition is composed of pure natural medicinal and edible Chinese herbal medicines, is green and environment-friendly, has no residue and durability, is simple in process, low in production cost and strong in practicability, can protect epithelial mucosa, particularly intestinal epithelial mucosa, from being invaded by pathogenic microorganisms, is beneficial to proliferation of intestinal probiotics, regulates balance of intestinal flora, improves immunity of organisms, particularly immunity level of intestinal mucosa, and improves health state and digestive function of the organisms, so that the effects of clearing heat, removing toxicity, inhibiting bacteria, resisting inflammation, resisting viruses and parasites, reducing incidence of coccidiosis and diarrhea, prolonging shelf life of feeds, improving utilization efficiency of the feeds and increasing benefit of rabbit raising are achieved.

The technical scheme provided by the invention for solving the problems is as follows: a Chinese herbal medicine functional anti-substitution composition containing garlic crude extracts for young rabbits comprises the following crude extracts of medicinal and edible Chinese herbal medicines in parts by mass after being uniformly mixed: 280-300 parts of garlic crude extract, 200-230 parts of astragalus polysaccharide, 140-160 parts of myrobalan crude extract, 150-170 parts of acanthopanax crude extract, 170-180 parts of hawthorn crude extract, 160-170 parts of poplar flower crude extract, 130-140 parts of dandelion crude extract, 130-150 parts of wild chrysanthemum crude extract, 170-190 parts of houttuynia cordata crude extract, 140-150 parts of portulaca oleracea crude extract and 130-160 parts of liquorice crude extract.

The invention also discloses a preparation method of the Chinese herbal medicine functional anti-substitution composition for the baby rabbits, which comprises the following steps,

weighing the Chinese herbal medicine crude extracts in the formula of the Chinese herbal medicine functional substitution antibody composition in sufficient parts by mass, adding the mixture into a stirrer to be fully mixed, finally subpackaging according to subpackaging amount, and carrying out vacuum sealing to obtain the Chinese herbal medicine functional substitution antibody composition for the baby rabbits containing the garlic crude extracts.

The invention also discloses application of the Chinese herbal medicine functional anti-substitution composition containing the garlic crude extract for the baby rabbits, wherein the adding proportion of the Chinese herbal medicine functional anti-substitution composition in the baby rabbit complete feed is 0.18-0.2%.

The baby rabbit series premix feed comprises the Chinese herbal medicine functional anti-substitution composition for the baby rabbits containing the garlic crude extract.

A complete feed for baby rabbits comprises the Chinese herbal medicine functional anti-bacterial composition for the baby rabbits containing the garlic crude extract.

The medicinal and edible Chinese herbal medicines used in the formula of the Chinese herbal medicine functional anti-tumor composition comprise the following main components and nutritional activities:

garlic crude extract:

the garlic is the fourth of ten medicinal and edible foods, namely black beans, mung beans and pearl barley, and the medicinal and edible part accounts for 82 percent. The garlic has the similar bactericidal function with antibiotics, which are called natural antibiotics, but has no drug residue of the antibiotics and no drug resistance to pathogenic bacteria. The crude extract of garlic not only contains all the nutritionally active substances contained in the crushed garlic, but also produces new nutritionally active substances during its extraction.

(1) 3-large barrier effect of garlic crude extract on maintaining animal health

The garlic crude extract is one of the most competitive products of the feed end, and has the remarkable advantages of 3 barrier functions for maintaining the health of animals:

and (4) microbial barrier effect. The garlic polysaccharide in the garlic crude extract has oligosaccharide nutrition activity, so that pathogenic bacteria can be competitively repelled, thus establishing intestinal flora balance taking probiotics as dominant flora in intestinal tracts, ensuring the health of the intestinal tracts and playing a role in microbial barrier in animal bodies.

The chemical barrier and the microbial barrier function in a dual manner. Although organic sulfides in the garlic crude extract have a wide antibacterial spectrum on pathogenic bacteria and have high inhibiting and killing effects on fungi and mold, the organic sulfides in the garlic crude extract have no inhibiting and killing effects on probiotics (such as lactobacillus casei and the like) in animal bodies including intestinal tracts. Therefore, the microbial community balance of the intestinal tract of the animal can be maintained, and the dual functions of a chemical barrier and a microbial barrier of the intestinal tract of the animal can be exerted in the animal body.

And (4) an immune barrier function. The garlic polysaccharide in the garlic crude extract can activate an immune system, enhance the immunity of an organism and play a role in immune barrier. The garlic crude extract has obvious functions of diminishing inflammation, relieving pain, resisting virus and resisting tumor, and is a well-known food and feed additive for enhancing the immunity of animals.

(2) The comprehensive nature of garlic crude extract nutrient active substance and its whole nutrient activity expressed by interaction in animal body

The crude extract of garlic contains the same nutrient active substances as the crushed garlic, including garlic polysaccharide and volatile oil. The overall nutritional activity of these nutritionally active substances exhibited by the interaction between the inside and outside of the animal:

broad-spectrum antibiosis, fly inhibition, maggot killing, disease spreading prevention and growth promotion;

oligosaccharide nutrition, probiotic effect, acidification of intestinal tract and flora balance;

inhibiting and killing mould, preventing mould, keeping fresh, covering peculiar smell, seasoning and improving quality;

the immunopotentiation and tumor inhibition, virus inhibition, coccidiosis resistance and diarrhea prevention of young animals;

the food calling and enhancing, the fishy smell and the odor are removed, the meat is tender and fresh, and the meat quality is improved;

clearing away pestilence and toxic materials, promoting blood circulation, removing blood stasis, relieving inflammation and pain, and relieving stress;

the mercury-lead metal, nitrite and cyanide in the feed are obviously reduced;

mycotoxins, bacterial toxins, chemical toxicities, and combinations thereof;

protecting liver and heart, brightening skin, strengthening physique and preventing diseasesLow nutritive activity. In addition, the garlic crude extract also has the health-care effects of resisting blood coagulation, preventing cerebral thrombosis and coronary heart disease, preventing arteriosclerosis, reducing blood pressure, resisting oxidation and virus, reducing blood fat, restoring physical strength and the like. Therefore, the garlic crude extract becomes a well-known natural flavoring agent, antibacterial agent and preservative.

(3) The feeding natural allicin and the chemical synthesis allicin only consider the nutritional activity of thioether compounds

The natural allicin (oil) for feeding only utilizes thioether compounds in the crushed garlic nutrient active substances, and does not contain garlic polysaccharide like the crude garlic extract. Because the natural allicin (oil) for feeding lacks the synergistic action of thioether compounds and garlic polysaccharide, the antibacterial and insecticidal action and the function of adjusting the balance of intestinal probiotics are not as good as those of a garlic crude extract.

The feed chemical synthesis allicin only imitates (chemically synthesizes) a few organic thioether compounds in natural allicin, does not consider the contribution of other nutritional active substances in the crushed garlic to the nutritional activity of the natural allicin, and particularly does not consider the contribution of garlic polysaccharide accounting for more than 70 percent of the total nutritional active substances, so that the overall synergistic effect expressed by the interaction among all the nutritional active substances contained in the crushed garlic is lacked.

Astragalus polysaccharide:

the astragalus polysaccharide is the crude extract of astragalus and has the function of nutrition activity. Astragalus polysaccharide is the most commonly used health-care qi-tonifying traditional Chinese medicine with obvious effect, and has no disease key body when a disease is treated. The theory of Chinese veterinarian considers that qi is the commander of blood, blood is the mother of qi, qi circulation is blood circulation, and qi stagnation is blood stasis. Only if the qi and blood in the animal body are sufficient, the normal operation of the functions of all internal organs in the animal body can be maintained, and the health of the animal is ensured. However, modern meat rabbits with high genetic production potential under high-density breeding are not subjected to various stresses all the time, so that rabbit groups are generally in a sub-health state, and have insufficient vital qi and serious blood stasis in vivo. Qi and blood deficiency, or an obstruction. It is necessary to add natural Chinese herbal medicines with qi invigorating function which are used as both medicine and food to rabbit ration to supplement qi and blood and prevent diseases in the bud.

(1) Enhancing the immune function of rabbits

The astragalus polysaccharide is the most basic natural Chinese herbal medicine with homology of medicine and food for improving the immunity of the lung and the respiratory system, and is added into the daily ration of the rabbit, so that the cell immunity and the humoral immunity of the rabbit can be improved, and the phagocytic function of a reticuloendothelial system and macrophages can be enhanced, so that the nonspecific immunity function of the rabbit can be increased, the constitution of the rabbit can be enhanced, and the occurrence of the sub-health state of the rabbit can be prevented. The concrete points are as follows: the health food can promote the development of spleen, thymus and other immune organs and increase their physique. Secondly, the proliferation of specific immune cells is promoted, and the immune function of the organism is enhanced:

promoting the proliferation and differentiation of B lymphocytes of the rabbits and the release of cytokines, secreting antibodies and increasing the concentration of serum antibodies of the rabbits, thereby enhancing the humoral immunity function of the rabbits;

the balance of the T cell subset CD4+ that promotes the immune process and the T cell subset CD8+ that suppresses the immune process is maintained (CD 4+/CD8 +). Thirdly, the proliferation effect on nonspecific immune cells:

stimulating NK cell proliferation, promoting interleukin-2 (IL-2) secretion while enhancing the killing power of the NK cell, and enhancing the immune regulation function of the NK cell;

increase the number of macrophages and reticuloendothelial cells and the phagocytic capacity of the cells;

enhancing function of erythrocyte as immune cell, promoting phagocytosis of neutrophil and macrophage, regulating production of antibody, IL-1, IL-2 and interferon-gamma (IFN-gamma) and other immunocompetence substances, and enhancing immune activity of phagocyte and NK cellAnd (4) sex. And fourthly, the secretion and expression of cytokines and the activity of intracellular messenger substances and various enzymes are regulated by acting on helper T cells.

In particular, APS not only has the enhancement effect on the low immune function of rabbits, but also has the effect of bidirectionally regulating the immune function of organisms, thereby being capable of recovering the immune function of rabbit disorders.

(2) Enhancing the antioxidant function of rabbit

The astragalus polysaccharide can increase the quality of animal immune organs, improve the activities of antioxidant enzymes such as glutathione peroxidase (GSH-Px), superoxide dismutase (SOD), Catalase (CAT) and the like, increase the clearance rate of free radicals while reducing the generation of the free radicals, and reduce the content of plasma lipid peroxide, and an obvious dose-effect relationship exists between the effect and the dosage of the astragalus polysaccharide. That is, the larger the amount of astragalus polysaccharide added, the higher the clearance of radicals and hydrogen peroxide within a certain dosage range.

(3) Antiviral action

The astragalus polysaccharide is used as an animal endogenous interferon inducer, on one hand, the content of CD4+ is increased by inhibiting the synthesis of viral protein, stimulating T cells and macrophages to induce and generate a plurality of cytokines such as interleukin, interferon and the like, thereby playing an antiviral role; on the other hand, the proliferation of spleen plasma cells and the production of antibodies are promoted, and humoral immunity is enhanced to exert an antiviral effect. Therefore, the astragalus polysaccharide plays a broad-spectrum antiviral role (such as infectious stomatitis, rotavirus disease and the like) by enhancing cellular immunity and humoral immunity.

(4) Antibacterial effect

The astragalus polysaccharide has broad-spectrum antibacterial effect, and has strong inhibiting and killing effects on staphylococcus aureus, hemolytic streptococcus A, pneumococci, salmonella, escherichia coli, dysentery bacillus and the like. The possible mechanisms are on the one hand an increase in the number of neutrophils that clear the bacteria and on the other hand an inhibition of the body's excessive anti-inflammatory response. The astragalus polysaccharide realizes the bacteriostasis and sterilization by adjusting the balance of the astragalus polysaccharide and the astragalus polysaccharide.

(5) Anti-stress effect

The anti-stress effect of the astragalus polysaccharide is shown as follows:

the stress resistance is realized by suppressing adrenal hyperplasia and thymus gland atrophy caused by stress reaction;

anti-stress by suppressing the failure abnormal reaction caused by stress reaction;

inhibiting animal fatigue, regulating metabolic enzyme, and relieving animal stress reaction.

(6) Enhancing metabolism

Astragalus polysaccharides can enhance the physiological metabolism of cells, promote the protein renewal and metabolism of serum and liver, which is probably the physiological and biochemical basis of astragalan strengthening function. For example, astragaloside contained in astragalus polysaccharide can obviously improve the energy metabolism of brain tissues and promote the utilization of energy substances by ischemic brain tissues.

(7) Liver protection effect

The astragalus polysaccharide has a liver protection effect, and is reflected in two aspects, on one hand, the element selenium in the astragalus polysaccharide can improve the activity of glutathione peroxidase and activate a detoxification enzyme system of the liver, so that liver cells are protected; secondly, the anti-parasitic infection function of the liver is enhanced by inducing the generation of nitric oxide synthase, thereby playing a role in protecting the liver.

(8) Regulating flora balance in animal intestinal tract

The astragalus polysaccharide can promote the growth of beneficial bacteria in the intestinal tract of animals and inhibit the proliferation of harmful bacteria, thereby regulating and controlling the balance of microbial flora in the intestinal tract and ensuring the health of the intestinal tract of animals.

In addition, Astragalus polysaccharides also has diuretic, heart protecting, blood viscosity reducing, thrombosis reducing, blood pressure regulating, blood sugar lowering, anoxia resisting, radioprotective, and antitumor effects.

Crude extracts of myrobalan:

the crude extract of the myrobalan is bitter, sour and astringent, has neutral nature, belongs to the lung and large intestine channels, contains tannin phenolic acid nutritional active substances, has the effects of relieving diarrhea with astringents, stopping bleeding and dysentery, repairing intestinal villi and promoting the recovery of diarrhea animals, has obvious enteritis effect, has antibacterial and antiviral nutritional activities, and is an effective good medicine for preventing and treating chronic dysentery.

Crude extract of acanthopanax senticosus:

the crude extract of Acanthopanax senticosus is pungent, bitter, slightly sweet and warm in nature. The health-care food has the nutritional activities of invigorating qi, tonifying spleen, tonifying kidney, soothing nerves, resisting stress, and relieving stress reaction caused by weaning, transferring materials, climate change and the like. The mechanism of its anti-stress lies in: firstly, the acanthopanax has the adaptive original effect similar to ginseng, and can enhance the nonspecific resistance of organisms to various pathogenic factors; the acanthopanax root can change the pathological process of the stress reaction of the organism; the hyperin in acanthopanax has obvious inhibition effect on lipid peroxidation in mitochondria of organisms, so that the oxidative stress of rabbits can be improved, and endogenous antioxidants such as superoxide dismutase (SOD), peroxidase (CAT), Glutathione (GSH) and the like can be saved; fourthly, the acanthopanax polysaccharide can enhance the immune function of the organism.

Crude extract of hawthorn:

the hawthorn crude extract is sour and sweet in taste and slightly warm in nature, belongs to spleen, stomach and liver channels, contains flavonoid, triterpenes and organic acid nutritional active substances, has the nutritional activities of invigorating stomach and nourishing spleen, promoting qi circulation and removing blood stasis, and helping digestion and removing food retention, is commonly used for meat food stagnation, gastric cavity fullness and diarrhea and dysentery abdominal pain, has the nutritional activities of promoting feed digestion and preventing dyspepsia, and has the following mechanism:

the hawthorn is rich in organic acid and is a natural acidifier;

the hawthorn fruit is rich in lipase, can promote fat digestion, andcan increase the secretion of digestive enzyme in stomach, so the hawthorn is also natural digestive enzyme.

Crude extract of poplar flower:

(1) property, flavor, channel tropism and efficacy of poplar flower crude extract

The poplar flower crude extract is cold in nature and bitter in taste, enters stomach and large intestine channels, has the effects of clearing heat and detoxicating, eliminating dampness and stopping dysentery, strengthening spleen and nourishing stomach, and relieving diarrhea with astringents, and is mainly used for treating bacillary dysentery and enteritis.

(2) Nutrient active substance contained in poplar flower crude extract

The crude extract of poplar flower is rich in microelements, flavonoids, saponins, organic acids, amino acids, polysaccharides, phenol glycosides, alkaloids and other nutrient active substances.

(3) Nutritional activity of crude extract of poplar flower

Firstly, the antibacterial, bactericidal and antiviral effects are as follows: the poplar flower crude extract has wide antimicrobial spectrum, can directly inhibit and kill pathogens, and can effectively prevent various pathogenic bacteria (escherichia coli, salmonella, pasteurella, proteus and staphylococcus) and infection caused by viruses. Can be combined with other medicinal and edible Chinese herbal medicines such as crude extract of Bulbus Allii to prevent coccidiosis and viral diseases. And secondly, the immunity function of the organism can be improved, the immunosuppression caused by the immunosuppressant can be resisted, and the resistance and the disease resistance of the organism can be enhanced. Thirdly, the anti-inflammatory and anti-stress effects can effectively relieve various stress reactions of animals during the disease attack period. Fourthly, astringe intestines, stop diarrhea and dysentery, improve the tension of animal stomach, intestinal muscles and sphincters, inhibit the contraction of smooth muscles, slow down the peristalsis of intestinal tracts, reduce the secretion function of stomach and intestines, show strong water-fixing function, astringe intestines, stop diarrhea and dysentery, and have obvious effect. Fourthly, the medicine has the function of intestinal mucosa 'immune barrier', which is specifically shown in the following steps:

protecting gastrointestinal mucosa, enhancing local immunity of intestinal mucosa, playing a role of mucosal immune barrier and improving the anti-infection capability of the young rabbits;

repairing injured small intestine villi, promoting small intestine villi proliferation and digestive function recovery, and preventing multiple and intractable diarrhea.

Crude extract of dandelion:

(1) flavor, channel tropism and efficacy of crude extract of dandelion

The crude extract of dandelion is cold in nature, sweet in taste, mild and slightly bitter. It enters liver, stomach, yangming, taiyin and foot shaoyin meridians. Has effects of clearing away heat and toxic materials, nourishing yin, cooling blood, resolving carbuncle (swelling), resolving hard mass, relaxing muscles and tendons, consolidating teeth, promoting lactation, replenishing essence, promoting diuresis, treating stranguria, invigorating spleen, regulating stomach function, relieving cough, eliminating phlegm, removing liver heat, and improving eyesight.

(2) Nutrient active substance contained in dandelion crude extract

The dandelion is rich in nutritional active substances and mainly comprises the following components:

taraxanol, sterol, saxitol, sterol, inositol, stigmasterol, lactucinol, beta-balsamic alcohol, beta-sitosterol, Arnica herb diol, etc.

Inulin, sucrose, fructose, glucose, pectin and other saccharides.

Cerotic acid, oleic acid, linoleic acid, caffeic acid, palmitic acid, melissic acid, p-hydroxyphenylacetic acid and the like.

Choline, vitamin C, vitamin D and other vitamins. In addition, herba Taraxaci also contains nutrient active substances such as taraxacin, resin, cordierite, chlorophyllin, xanthophyll and Ranunculus japonicus Temminck et Schlegel.

(3) Nutritional activity of crude extract of Taraxacum officinale

The dandelion has a strong inhibiting and killing effect on hemolytic streptococcus, catacoccus and staphylococcus aureus drug-resistant strains, and also has a certain inhibiting and killing effect on diplococcus pneumoniae, diplococcus meningitidis, typhoid bacillus, pseudomonas aeruginosa, diphtheria bacillus, proteus bacillus, dysentery bacillus, leptospira and the like. Researches show that the dandelion has good anti-infection effect as the traditional Chinese herbal medicine for clearing heat and removing toxicity, also has the effect of broad-spectrum antibiotics on certain diseases, and can replace the antibiotics to a certain extent. And secondly, the medicine has an antiviral effect and can cure viral influenza and viral hepatitis. In addition, the crude extract of herba Taraxaci can stimulate immunity, activate macrophage, and has anti-tumor effect. Thirdly, the functions of protecting liver, benefiting gallbladder, promoting urination and resisting endotoxin, the effect of the dandelion crude extract on benefiting gallbladder is more obvious than that of oriental wormwood, and the effect on animal chronic cholecystospasm and lithiasis is obvious. The dandelion crude extract has a good diuretic effect due to the potassium content, has a special effect on portal edema, and also has an anti-endotoxin effect.

Crude extract of wild chrysanthemum:

the crude extract of flos Chrysanthemi Indici is cool (slightly cold), pungent (slightly) bitter, heart meridian and liver meridian, and contains flos Chrysanthemi Indici polysaccharide, volatile oil, flavonoids (such as luteolin, acacetin, robinin, etc.), glycosides (such as chrysanthemin, robinin, etc.), esters (such as wild chrysanthemum lactone, etc.), alcohols, ketones (such as chrysanthenone, chrysanthemumone), ethers (such as chrysanthemumol, chrysanthenone, cis-spironolether, etc.), and organic acids (such as ursolic acid, palmitic acid, linoleic acid, etc.) as nutritional active substances. Has effects in resisting pathogenic microorganism, resisting various stresses, regulating immunity, relieving inflammation and fever, enhancing phagocytic ability of cell and liver reticuloendothelial system, promoting proliferation of probiotic bacteria and metabolism of organism, and improving digestive tract digestive enzyme activity.

The nutrient active substance contained in the crude extract of the wild chrysanthemum is the substance basis for playing the nutrient active role, and the essential oil is taken as the main component. Organic acid nutritional active substances such as ursolic acid, palmitic acid, linoleic acid and the like can reduce the pH of gastrointestinal tracts, particularly intestinal tracts of young rabbits, improve the activity of digestive enzymes, inhibit the growth of pathogenic bacteria, promote the proliferation of probiotics, maintain the microecological balance of the intestinal tracts, increase the complement concentration in the serum of weaned young rabbits, and increase the phagocytosis of neutrophils, monocytes and macrophages, thereby improving the functions of specific immunity (cellular immunity) and non-specific immunity (innate immunity) of organisms. The flavonoid nutrient active substance is the substance basis of multiple nutrient activities of the wild chrysanthemum flower crude extract, such as bacteriostasis, anti-inflammation, antioxidation, antivirus, immunity regulation and the like.

Crude extract of houttuynia cordata

The crude extract of houttuynia cordata is slightly cold (cool) in nature, pungent and bitter in flavor, and enters lung meridian. Has effects of clearing away heat and toxic materials, relieving diarrhea and dysentery, removing carbuncle, promoting pus discharge, relieving swelling, treating sore, promoting urination, relieving stranguria, eliminating dampness, relieving pain, invigorating stomach, resolving food stagnation, removing miasma, relieving summer heat, and treating snake venom. Contains volatile oil (such as houttuynin, decanoyl acetaldehyde, lauraldehyde, etc.), flavonoid glycosides (such as rutin, isoquercitrin, hyperoside, etc.), organic base, organic acid, sterols (such as houttuynia base, chlorogenic acid, stearic acid, oleic acid, linoleic acid, beta-sitosterol, etc.), minerals and trace elements (such as potassium chloride, potassium sulfate, calcium, phosphorus, iron, etc.), etc. Has antibacterial, antiviral, antioxidant, anticomplementary, diuretic, antiinflammatory, immunity enhancing, antitumor, and pneumonia and intestinal injury caused by influenza virus relieving effects.

Crude extract of Portulaca oleracea L

The crude extract of purslane is cold in nature and sweet and sour in taste, and enters heart, spleen, liver and large intestine meridians. Has effects of clearing away heat and toxic materials, cooling blood, stopping bleeding, removing blood stasis, relieving swelling, diminishing inflammation, relieving pain, invigorating qi, relieving epigastric distention, relieving constipation, eliminating dampness, stopping leukorrhagia, promoting urination, treating stranguria, and promoting intestine and miscarriage; meanwhile, the composition has the effects of clearing summer heat, removing food retention, removing intestinal dirt, treating carbuncle sore and stopping diarrhea. Contains multiple nutritional active substances such as organic acids (such as malic acid, citric acid, etc.), saccharides (such as fructose, sucrose, glucose, etc.), triterpenoids, flavonoids (such as apigenin, kaempferol), alkaloids (norepinephrine, dopamine, etc.), saponins such as betanin, isobetanin, etc., tannin, resin, OMEGA-3 (OMEGA-3) fatty acid, vitamins (such as vitamin A, B, vitamin C, vitamin E, etc.), etc. Has the effects of resisting bacteria, resisting oxidation, inducing diuresis, relieving swelling, lowering blood pressure, reducing inflammation, eliminating dust toxin, preventing and treating ulcer, promoting intestinal tract peristalsis, maintaining blood sugar stability of organism, improving lipid metabolism disorder of animals, and enhancing immunity.

Crude extract of licorice

The crude extract of licorice has sweet taste and mild nature, and has the functions of invigorating spleen and replenishing qi, clearing away heat and toxic material, eliminating phlegm and stopping cough, relieving spasm and pain, and harmonizing the drugs. The licorice crude extract contains triterpenes such as glycyrrhizic acid, glycyrrhetinic acid and the like and saponins thereof, flavonoids such as liquiritigenin, isoliquiritigenin, neoisoliquiritigenin and the like and carbohydrate nutrition active substances such as glycyrrhiza polysaccharide and the like, has the nutrition activities of resisting bacteria, viruses, inflammation and ulcer and improving the immunity, wherein the glycyrrhizic acid has mineralocorticoid activity and helps animals to maintain water and electrolyte balance in vivo under a high-heat environment. The crude extract of licorice is added into feed, and is commonly used for preventing weakness of spleen and stomach, lassitude and hypodynamia, palpitation and shortness of breath, cough and profuse sputum, spasm and pain of stomach and abdomen and limbs, carbuncle and sore toxicity, relieving toxicity and severity of medicines and the like of animals.

The formula principle of the invention is as follows:

the Chinese herbal medicine functional replacement therapy composition is a rabbit baby feed medicine-food homologous type Chinese herbal medicine replacement therapy product which is guided by the theory of Chinese veterinarian 'preventive treatment' and modern nutritional active substance theory, is prepared and processed according to the theory of yin and yang five elements, the theory of viscera and meridians, the theory of qi and blood and body fluid, and the theory of wei-defensive qi and ying-blood of traditional Chinese medicine, the attributes of four elements and five flavors of traditional Chinese medicines, cold and hot, cold and warm, ascending and descending and floating, sex and taste channel tropism and the like, and strictly according to the principles of 'strengthening healthy qi', 'balancing yin and yang', 'adjusting viscera', 'dialectically treating' and 'monarch, ministerial, assistant and guide' and physiological change rules and characteristics during the period from birth to sale and fattening of a baby rabbit.

The Chinese herbal medicine functional anti-bacterial composition has natural plants with specific nutritional activity, and the natural ingredients of the plants are complex and contain various nutritional active substances such as saponin, flavone, polysaccharide, organic acid and the like. The multiple natural nutritional active substances contained in the Chinese herbal medicines enable each medicine and food to be homologous with the natural Chinese herbal medicines and have multiple nutritional activities, and after combination, the multiple nutritional activities of integrally regulating and controlling the intestinal flora balance of the baby rabbit, maintaining the intestinal epithelial structure to be complete, promoting the intestinal health, improving the immunity of the organism, resisting bacteria, resisting viruses and the like are exerted.

Compared with the prior art, the invention has the advantages that: the functional Chinese herbal medicine composition screened by the test has a positive combination effect among nutritional active substances contained in the Chinese herbal medicines, so that the Chinese herbal medicines can regulate and control the balance of intestinal flora of the newborn rabbit, maintain the intestinal health, improve the immunity of the organism, inhibit and kill pathogenic microorganisms, reduce the diarrhea rate and the incidence rate of coccidiosis and promote the digestion of feed to show an overall synergistic effect, thereby improving the daily increase quality and the utilization rate of the feed of the newborn rabbit and creating value for farmers. In particular to baby rabbit feed containing the Chinese herbal medicine functional anti-substitution composition of claim 1, which does not contain antibiotics, antioxidants (such as ethoxyquinoline and the like), mildewproof agents and other chemical synthetic drugs, does not generate drug resistance, and has strong pertinence to various pathogenic factors causing diarrhea of weaned baby rabbits, so that the effect of preventing the diarrhea of the weaned baby rabbits is remarkable. The Chinese herbal medicine functional anti-substitution composition provided by the invention is green, safe, environment-friendly and obvious in effect, and can solve the problems of carcinogenesis, mutagenic effect, drug residue, drug resistance and the like caused by abuse of various antibiotics and chemical synthetic drugs. The whole-course health care scheme of the Chinese herbal medicine functional anti-substitution composition replaces chemical synthetic drugs and antibiotics in the feed of the young rabbits, conditions the sub-health state and the visceral functions of the young rabbits, reduces morbidity, creates value for customers and provides technical support for the sustainable development of the meat rabbits.

Detailed Description

The embodiments of the present invention will be described in detail with reference to specific embodiments, so that how to implement the technical means for solving the technical problems and achieving the technical effects of the present invention can be fully understood and implemented.

Example 1

The weight parts of the Chinese herbal medicine crude extracts of the Chinese herbal medicine functional antibody composition for the newborn rabbits containing the garlic crude extracts are as follows: 300 parts of garlic crude extract, 230 parts of astragalus polysaccharide, 160 parts of myrobalan crude extract, 170 parts of acanthopanax crude extract, 180 parts of hawthorn crude extract, 170 parts of poplar flower crude extract, 140 parts of dandelion crude extract, 150 parts of wild chrysanthemum crude extract, 190 parts of houttuynia cordata crude extract, 150 parts of purslane crude extract and 160 parts of liquorice crude extract.

Weighing the crude extracts of the Chinese herbal medicines with the same medicinal and edible sources according to the mass parts of the crude extracts in the formula, uniformly mixing, sealing and packaging.

Example 2

The weight parts of the Chinese herbal medicine crude extracts of the Chinese herbal medicine functional antibody composition for the newborn rabbits containing the garlic crude extracts are as follows: 280 parts of garlic crude extract, 200 parts of astragalus polysaccharide, 140 parts of myrobalan crude extract, 150 parts of acanthopanax crude extract, 170 parts of hawthorn crude extract, 160 parts of poplar flower crude extract, 130 parts of dandelion crude extract, 130 parts of wild chrysanthemum crude extract, 170 parts of houttuynia cordata crude extract, 140 parts of purslane crude extract and 130 parts of liquorice crude extract.

Weighing the crude extracts of the Chinese herbal medicines with the same medicinal and edible sources respectively according to the mass parts of the crude extracts in the formula, uniformly mixing, sealing and packaging.

Example 3

The weight parts of the Chinese herbal medicine crude extracts of the Chinese herbal medicine functional antibody composition for the newborn rabbits containing the garlic crude extracts are as follows: 290 parts of garlic crude extract, 215 parts of astragalus polysaccharide, 150 parts of myrobalan crude extract, 160 parts of acanthopanax crude extract, 175 parts of hawthorn crude extract, 165 parts of poplar flower crude extract, 135 parts of dandelion crude extract, 140 parts of wild chrysanthemum crude extract, 180 parts of houttuynia cordata crude extract, 145 parts of purslane crude extract and 145 parts of liquorice crude extract.

Example 4

The Chinese herbal medicine functional anti-substitution composition for the baby rabbits provided in the example 1, a special premix for the baby rabbits, which does not contain antibiotics, antioxidants (such as ethoxyquinoline and the like), mildewproof agents, flavoring agents and other raw materials, are prepared into a baby rabbit complete feed containing 0.2% of the Chinese herbal medicine functional anti-substitution composition for the baby rabbits provided in the example 1, and the formula and the nutritional level are shown in the daily ration composition and the nutritional level in the table 1.

Example 5

The Chinese herbal medicine functional anti-substitution composition for the baby rabbits provided in the example 2 is mixed with special premix for the baby rabbits which does not contain antibiotics, antioxidants (such as ethoxyquinoline and the like), mildewproof agents and flavoring agents and other raw materials to form the baby rabbit complete feed containing 0.18% of the Chinese herbal medicine functional anti-substitution composition for the baby rabbits provided in the example 2. Except that the calcium hydrophosphate in the composition and the nutritional level of the daily ration in the table 1 is adjusted to be 0.62, the composition and the nutritional level of other formulas are the same as the composition and the nutritional level of the daily ration in the table 1.

Example 6

The Chinese herbal medicine functional anti-substitution composition for the baby rabbits provided in the example 3 is mixed with special premix for the baby rabbits which does not contain antibiotics, antioxidants (such as ethoxyquinoline and the like), mildewproof agents and flavoring agents and other raw materials to form the baby rabbit complete feed containing 0.19% of the Chinese herbal medicine functional anti-substitution composition for the baby rabbits provided in the example 3. Except that the calcium hydrophosphate in the daily ration composition and the nutrition level in the table 1 is adjusted to be 0.61, the rest formula compositions and the nutrition level of the complete feed for the young rabbits are the same as the daily ration composition and the nutrition level in the table 1.

Test examples

The invention takes the non-anti baby rabbit complete pellet feed prepared in example 4 as an example to carry out the following tests, which further illustrate the beneficial effects of the invention:

test animals and test design

By adopting a single-factor test design, 1200 healthy Yila mating line commercial meat rabbits which are 30 days old, close in physique quality (695.43 +/-37.68 g) and disease-free at weaning on the same day are randomly divided into 2 treatments according to the pairing principle of male and female halves, and the treatments are 600 treatments (10 repetitions of each treatment and 60 repetitions of each treatment) respectively.

Test site

The test was conducted in a rabbit farm of a certain scale located in Mengyin county, Shandong province, from 9 days 12 to 29 days 12 months 2020. The rabbit cages are thoroughly cleaned before the test rabbits enter the houses, and are disinfected by flame and then by disinfectant spray. The control group and the test group are simultaneously raised on the top, middle and lower layers of a 7 th fattening rabbit house 3 layers of the delta-shaped vertical rabbit cages, 6 young rabbits are raised in each cage, the test group and the control group are respectively raised on the left side and the right side of the delta-shaped vertical rabbit cage, and 600 weaned young rabbits are raised respectively. The rabbit farm is used for immunization and parasite expelling according to the conventional procedures of the rabbit farm.

Test daily ration and nutritional level

On the basis of daily ration of a control group, the test group uses 0.2 percent of medicinal and edible Chinese herbal medicine functional anti-substitution composition to replace mequindox (mequindox), an antioxidant, an anti-mildew agent and a flavoring agent in the control group. The basal diet of the test group and the control group are the same, and the composition and the nutrition level of the test diet are shown in table 1. The test ration was processed by the own feed processing plant of the rabbit farm into complete pellet feed with a diameter of about 5 mm.

TABLE 1 diet composition and Nutrition levels

The rabbit special premix comprises (%): 17.39 trace elements, 26.09 lysine, 17.39 choline chloride, 8.70 methionine, 2.61 sweetener, 1.74 anticoccidial drug, 8.70 vitamin, 8.70 antioxidant (control group), 8.70 flavoring agent (control group), etc.;

the Chinese herbal medicine functional anti-diarrhea composition is mequindox in a control group, and the premix of the test group does not contain antioxidant, mildew preventive and flavoring agent.

Feeding mode

Feeding manually, feeding by a specially-assigned person twice a day respectively at 8:00 in the morning and 17:00 in the afternoon. The food can be taken freely and the water can be drunk freely. The feeding, feces (diarrhea) and activity of the test baby rabbits, and the feed consumption and death number of the test baby rabbits were observed every day. In view of the habit of feeding rabbits at night, the feed is added according to the amount of the residual materials in the feed tank in the early feeding process, the feed is added more according to the condition of the residual materials in the early feeding process and the increase of the feed along with the age of the rabbit, and only a small amount of crushed powder is needed to be fed in the next morning.

Measurement index

(1) Determination of conventional nutritional ingredients

Crude protein, crude fiber, calcium, and total phosphorus were determined by the method described for Yangshen.

(2) Mortality rate

Mortality (%): the number of dead baby rabbits in the test group (or the control group) from the weaning day (i.e. the day of the test start, i.e. 12 and 9 days in 2020) to the 21 st day (i.e. 12 and 29 days in 2020) is calculated respectively, and is divided by the total number of the baby rabbits (600) in the test group (or the control group) on the weaning day, so that the mortality rate of the test group (or the control group) on the 21 st day of weaning is obtained.

(3) Average daily gain of body mass

Average daily bulk mass (g/d): the average daily gain is obtained by taking the fasting balance mass in the morning of weaning as the initial mass, taking the fasting balance mass in the morning of the next day (12 months and 30 days in 2020) of the test as the final mass, and dividing the final mass minus the initial mass (namely the net gain mass in the whole period) by the actual feeding days.

(4) Average daily food intake

Average daily feed intake (g/d): the average daily feed intake is obtained by dividing the accumulated feeding amount of the test group (or the control group) from the current weaning day to the 21 st day by the total number of the tested young rabbits (600) on the current weaning day of the test group (or the control group) and then by the actual test days (21 days).

(5) Material to weight ratio

The material weight ratio is as follows: the average daily food intake and average daily gain ratio (F/G) were taken.

Statistical analysis

The standard deviation was calculated using the STDEV function in Excel, and the t-test was performed using TTEST therein, to check the significance of the difference in the mean number of correlated samples between the two single-factor groups, test level α = 0.05. Results are expressed as "mean ± standard deviation".

Test results

(1) Mortality rate

The mortality rate at 21 days of weaning in the control group and the test group is shown in Table 2 from the beginning of the test at 9 days 12/2020 to the end of the 21 days of the Japanese test at 29/12.

TABLE 2 Effect of herbal functional replacement composition on mortality of weaned 21-day newborn rabbits

As can be seen from table 2, from weaning to day 21, 26 of the test groups died, with a mortality rate of 4.33%; 29 of the control group died, the mortality rate was 4.83%, and the mortality rate of the test group was 0.50% less than that of the control group (4.33% vs 4.83%).

(2) Average daily gain of body mass

TABLE 3 influence of Chinese herbal medicine functional anti-body composition on average daily weight gain and feed-weight ratio of 21-day-old weaned rabbits

Group of	Initial body mass/g	Mass of end-of-line/g	Average daily gain mass/g	Material to weight ratio (F/G)
					Control group	696.79^a±37.27	1433.26^b±43.71	35.07^b±1.38	3.08^a±0.12
Test group	694.07^a±36.89	1597.28^a±47.48	43.01^a±1.86	2.51^b±0.15

Note: the data in the same column are marked with different lower case letters to indicate significant difference (P < 0.05), and a > b.

As shown in Table 3, the mean daily gain mass of the test group was 43.01. + -. 1.86 g, the mean daily gain mass of the control group was 35.07. + -. 1.38 g, the test group was 7.94 g higher than the control group, and the difference was significant by t-test (P < 0.05).

(3) Average daily food intake

After the test is finished by late feeding on the day of 29 days from 2020 to 12 months, 34 bags (1360 kg) of the test group and the control group are consumed. The test group and the control group were fed with 107.94 g of feed per rabbit on average per day. During the whole test period, the baby rabbits of the test group like the baby rabbits of the control group, like eating and snatching, and no baby rabbit refuses to eat, which shows that the test material has better fresh-keeping and food calling effects even though the flavoring agent, the antioxidant and the mildew preventive are removed.

(4) Material to weight ratio

The lower the feed weight ratio, the higher the feed utilization. As can be seen from Table 3, in the test period of 1-21 days, the material weight ratio of the test group is 2.51 +/-0.15, the control group is 3.08 +/-0.12, the test group is 0.57 less than the control group, and the difference is significant (P is less than 0.05) through t test.

(5) Shelf life

The test group diets were produced 12 months and 1 day 2020, to 12 months and 29 days, 29 days old. Although the feed is stored in a test rabbit house in a winter low-temperature (according to the actual measurement that the temperature of 12 months and 1-29 days is between-3 ℃ and 5 ℃), the temperature of the rabbit house is maintained to be more than 33 ℃, the test material containing the Chinese herbal medicine functional substitution composition of claim 1 is like the fragrance during the whole test period, and the test rabbit is favored to eat, which shows that the Chinese herbal medicine functional substitution composition of claim 1 also has the functions of oxidation resistance and preservation, and the antioxidant and the mildew preventive are not required to be added into the feed of the baby rabbit added with the Chinese herbal medicine functional substitution composition of claim 1.

The effect of the Chinese herbal medicine functional anti-bacterial composition for the newborn rabbit is illustrated

Application example 1

Address: yellow sand paved Zhongtong village in Tongshan county of Hubei province

Farmer (farm, district) name: tongshan Kangsheng Rabbit industry development Co Ltd

The contact person: wu-wu fruit farm

2000 commercial replacement weaned newborn rabbits were randomly divided into 2 groups of 1000 rabbits, each test group was fed the non-resistant newborn rabbit complete pellet feed prepared in example 5, and the control group was fed the same meat-type newborn rabbit complete pellet feed, but not containing the herbal functional anti-bacterial composition for newborn rabbits of the present invention, but containing antibiotics, antioxidants, mildewcides, fragrances and the like. The test period is 21 days from 10 days to 30 days of Yuanyue 2021. The results show that: (1) weaning 21-day mortality 49 young rabbits dead in 21 days of weaning as a control group, with a mortality rate of 4.90%; 45 young rabbits died in the test group, and the death rate is 4.50%. (2) Average daily gain body mass control group weaned newborn rabbits initial average body mass 687.64 (+ -39.57) g, average body mass 1453.51 (+ -45.35) g for 21 days of weaning, average daily gain body mass 36.47 (+ -1.55) g; the initial average body mass of weaned newborn rabbits of a test group is 680.85 (+ -41.05) g, the average body mass of the weaned newborn rabbits of 21 days is 1616.89 (+ -44.26) g, the average daily gain body mass is 44.59 (+ -2.37) g, 8.12 g more of the test group is compared with that of a control group, and the difference is obvious (P < 0.05). (3) After the average daily food intake reaches the end of the test day of Yuanyue 30 days and is fed later, 57 bags (2280 kg in total) are consumed by the test group and the control group. The test group and the control group eat 108.57 g of feed per rabbit on average per day. During the whole test period, the baby rabbits of the test group like the baby rabbits of the control group, like eating and snatching, and no baby rabbit refuses to eat, which shows that the test material has better fresh-keeping and food calling effects even though the flavoring agent, the antioxidant and the mildew preventive are removed. (4) Dividing the daily feed intake of the rabbits for the test by the average daily body mass of the rabbits for the test to obtain the feed-weight ratio of the rabbits for the test, wherein the higher the feed-weight ratio is, the lower the feed utilization rate is; conversely, the lower the feed weight ratio, the higher the feed utilization. The feed-meat ratio of the test group rabbit is 2.43, the feed-meat ratio of the control group rabbit is 2.98, the feed-meat ratio of the test group rabbit is 0.55 less than that of the control group rabbit, and the difference is obvious (P is less than 0.05).

Application example 2

Address: wei of Li Jia village in high-new district of Xinyu city of Jiangxi province

Farmer (farm, district) name: xinyu city xingan breeding professional cooperative society

The contact person: length of the scene of the lesser east

1500 commercial replacement weaned newborn rabbits were randomly divided into 2 groups of 750 animals, each of which was fed with the non-resistant newborn rabbit complete pellet feed prepared in example 6, and the control group was fed with the same meat-type newborn rabbit complete pellet feed, but not containing the herbal functional anti-bacterial composition for newborn rabbits of the present invention, but containing antibiotics, antioxidants, mildewcides, fragrances and the like. The test period is 21 days from 3 months and 2 days to 22 days in 2021. The results show that: (1) weaning 21-day mortality 37 young rabbits die in 21 days of weaning as a control group, and the mortality rate is 4.93%; 33 young rabbits died in the test group, and the death rate is 4.40%. (2) Average daily gain body mass control group weaned newborn rabbits initial average body mass 681.47 (+ -34.36) g, average body mass 1471.70 (+ -43.81) g for 21 days of weaning, average daily gain body mass 37.63 (+ -1.83) g; the initial average body mass of weaned newborn rabbits of the test group is 687.42 (+ -37.85) g, the average body mass of 1653.63 (+ -49.48) g in 21 days of weaning, the average daily gain mass is 46.01 (+ -2.41) g, the number of the test group is more than 8.38 g than that of the control group, and the difference is significant (P < 0.05). (3) After the test ended day of late feeding from 2021 to 22 months of 3, the average daily food consumption was 43 bags (1720 kg in total) for each of the test group and the control group. The test group and the control group were fed with 109.21 g of feed per rabbit on average per day. During the whole test period, the baby rabbits of the test group like the baby rabbits of the control group, like eating and snatching, and no baby rabbit refuses to eat, which shows that the test material has better fresh-keeping and food calling effects even though the flavoring agent, the antioxidant and the mildew preventive are removed. (4) Dividing the average daily feed intake of the rabbits for the test by the average daily gain mass of the rabbits for the test to obtain the feed-weight ratio of the rabbits for the test, wherein the higher the feed-weight ratio is, the lower the feed utilization rate is; conversely, the lower the feed weight ratio, the higher the feed utilization. The feed-meat ratio of the test group rabbit is 2.37, the feed-meat ratio of the control group rabbit is 2.90, the feed-meat ratio of the test group rabbit is 0.53 less than that of the control group rabbit, and the difference is obvious (P < 0.05).

The foregoing is merely illustrative of the preferred embodiments of the present invention and is not to be construed as limiting the claims. The present invention is not limited to the above embodiments, and the specific structure thereof is allowed to vary. All changes which come within the scope of the invention as defined by the independent claims are intended to be embraced therein.

Claims

1. A Chinese herbal medicine functional anti-substitution composition for baby rabbits containing garlic crude extracts is characterized in that: the medicine is prepared by uniformly mixing the following crude extracts of medicinal and edible Chinese herbal medicines in parts by mass: 280-300 parts of garlic crude extract, 200-230 parts of astragalus polysaccharide, 140-160 parts of myrobalan crude extract, 150-170 parts of acanthopanax crude extract, 170-180 parts of hawthorn crude extract, 160-170 parts of poplar flower crude extract, 130-140 parts of dandelion crude extract, 130-150 parts of wild chrysanthemum crude extract, 170-190 parts of houttuynia cordata crude extract, 140-150 parts of portulaca oleracea crude extract and 130-160 parts of liquorice crude extract.

2. A method for preparing a herbal functional antagonist composition for young rabbits comprising crude garlic extract according to claim 1, comprising: the method comprises the following steps of,

weighing the Chinese herbal medicine crude extracts in the formula of the Chinese herbal medicine functional substitution antibody composition of claim 1 in sufficient parts by mass, adding the weighed materials into a stirrer for fully mixing, finally subpackaging according to subpackaging amount, and carrying out vacuum sealing to obtain the Chinese herbal medicine functional substitution antibody composition for the baby rabbits containing the garlic crude extracts.

3. The use of a herbal functional antagonist composition according to claim 1, comprising garlic crude extract for young rabbits, characterized in that: the addition proportion of the feed in the complete feed for the young rabbits is 0.18 to 0.2 percent.

4. A series of premixed feed for young rabbits is characterized in that: a herbal functional replacement composition for young rabbits comprising the crude garlic extract as set forth in claim 1.

5. A complete feed for young rabbits is characterized in that: a herbal functional replacement composition for young rabbits comprising the crude garlic extract as set forth in claim 1.