CN107333985B

CN107333985B - Pig phagostimulant and preparation method thereof

Info

Publication number: CN107333985B
Application number: CN201710616576.4A
Authority: CN
Inventors: 刘平祥; 程龙梅; 陆应诚; 刘金萍; 罗敏瑜
Original assignee: Guangdong Driving Force Bio Tech Co ltd; Guangzhou Sanxing Biotechnology Co ltd
Current assignee: Guangdong Driving Force Biotechnology Group Co ltd; Guangzhou Sanxing Biotechnology Co ltd
Priority date: 2017-07-26
Filing date: 2017-07-26
Publication date: 2020-07-17
Anticipated expiration: 2037-07-26
Also published as: CN107333985A

Abstract

The invention provides a phagostimulant for pigs, which comprises nucleotide, zymosan, glutathione, sugar and a Chinese herbal medicine compound, wherein the nucleotide is as follows by weight: and (3) yeast polysaccharide: glutathione: sugar: 25-30 parts of Chinese herbal medicine compound: 15-20: 10-15: 10-20: 15-20. The combination of the nucleotide, the zymosan, the glutathione source, the stevioside and the fructose is combined with the Chinese herbal medicines reasonably, so that the phagostimulant has an outstanding effect on improving the feed intake of pigs.

Description

Pig phagostimulant and preparation method thereof

Technical Field

The invention belongs to the technical field of feed additives, and particularly relates to a pig phagostimulant and a preparation method thereof.

Background

The traditional food calling method is characterized in that the food calling agent can stimulate taste buds to produce short-time appetite, so that an organism loses the ability of retort discrimination on bad raw materials in a short time, generally, the food calling agent has no nutritive value, and the improvement of the gastrointestinal tract function of animals and the reduction of the oxidative stress of the organism are not considered, so that the digestion and absorption functions of the gastrointestinal tract are improved. Therefore, the food calling based on the function of stimulating taste buds only can not be continued for a long time because the digestion and absorption functions are not correspondingly improved after the food intake is improved and the feedback inhibition is easy to generate.

CN 104171554A discloses a lactating sow feed capable of improving immunity and survival rate of piglets, which comprises the following components: corn, bean pulp, wheat bran and premix; wherein, the premix comprises the following components: bee pollen, composite zymosan, garlic dry powder, branched chain amino acid, a microbial preparation, glutamine, an organic acidifier, whey protein concentrate, animal protein, calcium dihydrogen phosphate and calcium carbonate, wherein the composite zymosan comprises nucleotide, zymosan and glutathione, but the composite zymosan in the technology has the functions of improving the immunity of animals and removing in vivo freedom so as to achieve the aim of improving the immunity and survival rate of piglets, and is different from the aim of the invention.

CN 105124193A discloses a nucleotide slag type meat duck compound feed and a preparation method thereof, wherein the compound feed is prepared from the following raw materials: corn, peanut meal, corn DDGS, 46% cottonseed meal, flour, nucleotide dregs, duck oil, hydrolyzed feather meal, meat duck premix and complex enzyme, wherein the nucleotide is included, and a traditional Chinese medicine additive is added into the feed, but the feed is used for reducing the production cost of the meat duck feed, improving the feed utilization rate and improving the production performance of the meat duck. Different from the effect of improving the feed intake of pigs, which is provided by the invention.

CN 104381718A is a medicated core feed for resisting pig bacterial diseases, which comprises Chinese medicinal extract, ultramicro powder, biological fermentation product and nucleotide. CN 104522364A discloses a drug core type feed for resisting porcine viral diseases, which comprises traditional Chinese medicine extract, superfine powder, biological fermentation product and nucleotide. The effect of the nucleotide and the Chinese herbal medicine in the technology is used for preventing and treating diseases, and is different from the effect of the invention.

Disclosure of Invention

In order to solve the problems that the feed intake of pigs cannot be improved for a long time in the prior art, the invention provides a pig feed, which has the following specific technical scheme:

the pig phagostimulant comprises nucleotide, zymosan, glutathione, sugar and a Chinese herbal medicine compound, wherein the nucleotide is as follows by weight: and (3) yeast polysaccharide: glutathione: sugar: 25-30 parts of Chinese herbal medicine compound: 15-20: 10-15: 10-20: 15-20.

Preferably, the ratio of nucleotide: and (3) yeast polysaccharide: glutathione: sugar: the Chinese herbal medicine compound is 27: 16: 12: 16: 18.

preferably, the addition amount of the phagostimulant in the feed is 0.2-1.5 kg/t.

Preferably, the addition amount of the phagostimulant in the feed is 1 kg/t.

Preferably, for complete feed, the addition amount of the phagostimulant is 0.4-0.5 kg/t; for piglet feed, the addition amount of the phagostimulant is 0.2-0.3 kg/t; for the feed of the medium and large pigs, the addition amount of the phagostimulant is 0.25-0.3 kg/t; for the feed for nursing sows, the addition amount of the phagostimulant is 0.25-0.3 kg/t.

Preferably, the nucleotide is baker's yeast extract.

Preferably, the Chinese herbal medicine compound consists of 20-30 parts of radix ophiopogonis, 10-15 parts of dried orange peel, 10-15 parts of codonopsis pilosula, 15-20 parts of bighead atractylodes rhizome, 15-20 parts of poria cocos, 15-20 parts of mangnolia officinalis, 10-15 parts of fructus psoraleae and 15-20 parts of liquorice in parts by weight, and is crushed and sieved.

Preferably, the Chinese herbal medicine compound consists of 25 parts of radix ophiopogonis, 23 parts of dried orange peel, 23 parts of codonopsis pilosula, 23 parts of bighead atractylodes rhizome, 23 parts of poria cocos, 22 parts of mangnolia officinalis, 12 parts of fructus psoraleae and 23 parts of liquorice in parts by weight, and is crushed and sieved.

Preferably, the sugar comprises stevioside and fructose, and the mass ratio of the stevioside to the fructose is 1-2: 1-2.

Preferably, the phagostimulant also comprises table salt, and the addition amount of the table salt in the feed is 3-5.5 kg/t. The salt and nucleotide have synergistic effect.

Preferably, the addition amount of the table salt in the feed is 4.0-5.5kg/t for the medium and large pigs.

Preferably, 1.5kg/t of baking soda is added into the phagostimulant, and the addition amount of the salt in the feed is 4.0-5.0 kg/t.

A preparation method of pig phagostimulant is obtained by uniformly mixing the components in the formula.

The nucleotide can promote the growth performance of animals, the development of gastrointestinal tracts and the disease resistance, 1) the growth regulation effect of the nucleotide, the nucleotide is taken as a hormone medium, namely a second messenger is involved in the metabolic processes of various enzymes and growth factors, has important effects on the division, differentiation and development of cells and can promote the synthesis of proteins, and exogenous nucleotide can promote the growth, development and maturation of digestive organs such as gastrointestinal tracts and the like and reduce the energy consumption of the animals when the nucleotides are synthesized from the beginning.2) the feeding attraction effect of the nucleotide, a large number of researches show that nitrogen-containing compounds such as the nucleotide and the like have specific effects on taste, olfactory nerves and chemoreceptors of aquatic animals, so the nitrogen-containing compounds can be used as main effective components of the feeding attraction agent of the aquatic animals.

The action of the nucleotide as the phagostimulant in the livestock and poultry breeding is different from that of the aquatic products, the phagostimulant action of the nucleotide on the aquatic products is mainly due to the result of stimulating taste organs, and the nucleotide mainly promotes the intestinal health and improves the immunity of organisms on the livestock and poultry, thereby fundamentally improving the feed intake of animals. The renewal of intestinal mucosa cells only needs a few days (2-3 days), so a large amount of nucleotide is needed for better promoting the intestinal health and maintaining the digestive and absorptive functions of animals; the nucleotide as the phagostimulant has the advantages that for young animals, fast-growing animals and swine herds in immune excitation and stress states, the cell division and proliferation are accelerated, the nucleotide requirement is suddenly increased, and therefore, enough nucleotide must be additionally supplemented. The nucleotide is a key nutrient component in the milk of the sow and is also the most needed nutrient for the young piglets, and the nutrient component is generally lack in the feed for the piglets, so that the addition of the nucleotide is the nutrient requirement on one hand and has a good food calling effect by simulating the components of the pig milk on the other hand.

The nucleotide of the invention is baker's yeast extract, but not beer yeast extract, has good taste and does not contain the bitter taste of hops.

And (3) yeast polysaccharide: the mannan can be combined with pathogenic bacteria competitively, and the yeast cell wall polysaccharide has the characteristic of acidolysis resistance, can completely pass through the digestive tract without being damaged and degraded by gastric acid, digestive enzymes and the like, so that pathogenic bacteria can be carried and discharged to the outside of the body through the intestinal tract, thereby effectively reducing the occurrence of intestinal diseases. The yeast cell wall polysaccharide also has strong adsorption effect on mycotoxin and can effectively resist the toxicity of the mycotoxin. Therefore, the zymosan can effectively protect the intestinal tract from being invaded by harmful bacteria.

Glutathione (GSH) is a tripeptide containing sulfhydryl group, which is combined by glutamic acid, cysteine and glycine, and has antioxidant and integrated detoxifying effects. Its main physiological function is to scavenge free radicals in vivo, and to act as an important antioxidant in vivo to protect thiol groups in molecules such as many proteins and enzymes. Not only can eliminate free radicals, but also can improve the immunity of the organism. In addition, glutathione also protects hemoglobin from oxidation by hydrogen peroxide, free radicals, etc., thereby allowing it to continue to function normally in transporting oxygen.

The sweet taste of the fructose is pure and lasting, the sweet taste is 250-450 times of that of stevioside, the bitter taste of the medicine can be covered, and when the stevioside and the fructose are mixed for use, the sweet taste is pure, and the sweetness can achieve a synergistic effect.

The reasonable compatibility of several medicinal materials in the composite Chinese herbal medicine is cooperated with the components of the phagostimulant, so that the effect is better.

Radix ophiopogonis: sweet, slightly bitter and slightly cold in nature. It enters stomach, lung and heart meridians. Has the effects of nourishing yin and moistening lung, benefiting stomach and promoting fluid production, and clearing heart fire and relieving restlessness, and is used for treating dry cough due to lung dryness, phthisis due to yin deficiency, pharyngitis and pharyngalgia, body fluid injury and thirst, internal heat and diabetes, vexation and insomnia, intestinal dryness and constipation, etc., and is listed as the superior product for nourishing yin and moistening lung by Shennong herbal.

Dried orange peel: bitter and pungent in flavor and warm in nature. It enters lung and spleen meridians. Regulate qi to invigorate spleen, dry dampness and resolve phlegm. Can be used for treating abdominal distention, anorexia, vomiting, diarrhea, cough, and excessive phlegm.

Codonopsis pilosula: sweet and mild in taste. Tonify middle-jiao and Qi, harmonize stomach and promote fluid production, dispel phlegm and relieve cough. Can be used for treating spleen deficiency, anorexia, loose stool, myasthenia of limbs, palpitation, short breath, dry mouth, spontaneous perspiration, rectocele, and abnormal yin.

White atractylodes rhizome: bitter and sweet in taste and warm in nature. It enters spleen and stomach meridians. Invigorate spleen, replenish qi, dry dampness, induce diuresis, stop sweating, prevent abortion. Can be used for treating spleen deficiency, anorexia, abdominal distention, diarrhea, phlegm retention, dizziness, palpitation, edema, spontaneous perspiration, and threatened abortion.

Tuckahoe, poria cocos: sweet and bland in flavor and mild in nature. It enters heart, lung, spleen and kidney meridians. Induce diuresis and drain dampness, invigorate spleen and calm heart. Can be used for treating edema, oliguria, phlegm and fluid retention, dizziness, palpitation, spleen deficiency, anorexia, loose stool, diarrhea, uneasiness, palpitation, and insomnia.

Magnolia officinalis: bitter and pungent in flavor and warm in nature. It enters spleen, stomach and large intestine meridians. Move qi and remove food retention, dry dampness and remove fullness, check adverse rise of qi and relieve dyspnea. Mainly treats dyspepsia; abdominal distension and constipation; dampness obstructing the middle energizer, gastric fullness, vomiting and diarrhea; phlegm obstructing the adverse flow of qi; fullness in chest, dyspnea and cough.

Psoralea fruit: bitter and pungent in flavor and warm in nature. It enters kidney and spleen meridians. Invigorating kidney, supporting yang, arresting spontaneous emission, arresting polyuria, treating lumbago due to kidney deficiency, frequent micturition, infantile enuresis, renal leakage, warming spleen, relieving diarrhea, and relieving asthma.

Licorice root: sweet and mild in taste. It enters spleen, stomach and lung meridians. Tonify qi, strengthen the middle-jiao, relieve spasm and pain, moisten lung, arrest cough, purge fire, remove toxicity, and harmonize the drugs.

The invention has the beneficial effects that:

the phagostimulant strongly stimulates the feeding, has the function of resisting oxidative stress, eliminates the decrease of the feed intake caused by stress such as high temperature and the like, simultaneously provides nutrition required by the rapid metabolism of intestinal mucosa, ensures the digestive absorption of the intestinal tract, and has good effect of improving the feed intake and the immunologic function of pigs. The phagostimulant is sweet in taste and good in palatability; the warm, cold and neutral properties are combined, and yin and yang are coordinated; the traditional Chinese medicine composition mainly enters spleen and stomach channels, strengthens spleen and benefits stomach, is beneficial to the absorption of nutrient substances by spleen and stomach, and is beneficial to reducing the wet arthralgia and swelling of pig joints caused by perennial dampness of pigsties due to diuresis and dampness excreting of a plurality of medicines. Through the combination of the nucleotide, the zymosan, the glutathione source, the stevioside and the fructose and the reasonable compatibility of the Chinese herbal medicines, the phagostimulant has outstanding effect on improving the feed intake of pigs.

Detailed Description

The following further illustrates embodiments of the invention:

example 1

According to the mass parts, 27 parts of nucleotide, 16 parts of zymosan, 12 parts of glutathione source, 10 parts of stevioside, 6 parts of fructose and 18 parts of Chinese herbal medicine are mixed, wherein the formula of the Chinese herbal medicine is as follows: 25 parts of dwarf lilyturf tuber, 13 parts of dried orange peel, 12 parts of pilose asiabell root, 17 parts of largehead atractylodes rhizome, 18 parts of Indian buead, 18 parts of officinal magnolia bark, 12 parts of malaytea scurfpea fruit and 17 parts of liquoric root, and the traditional Chinese medicine is obtained by mixing, crushing and sieving.

Example 2

The preparation method comprises the following steps of (by mass parts) nucleotide 25 parts, zymosan 20 parts, glutathione source 10 parts, stevioside 10 parts, fructose 5 parts and Chinese herbal medicine 20 parts, wherein the Chinese herbal medicine formula is as follows: 20 parts of dwarf lilyturf tuber, 13 parts of dried orange peel, 15 parts of pilose asiabell root, 15 parts of largehead atractylodes rhizome, 20 parts of Indian buead, 15 parts of officinal magnolia bark, 12 parts of malaytea scurfpea fruit and 17 parts of liquoric root, and the traditional Chinese medicine is obtained by mixing, crushing and sieving.

Example 3

According to the mass parts, 30 parts of nucleotide, 15 parts of zymosan, 15 parts of glutathione source, 5 parts of stevioside, 5 parts of fructose and 15 parts of Chinese herbal medicine are mixed, wherein the formula of the Chinese herbal medicine is as follows: 25 parts of dwarf lilyturf tuber, 13 parts of dried orange peel, 12 parts of pilose asiabell root, 17 parts of largehead atractylodes rhizome, 18 parts of Indian buead, 18 parts of officinal magnolia bark, 12 parts of malaytea scurfpea fruit and 17 parts of liquoric root, and the traditional Chinese medicine is obtained by mixing, crushing and sieving.

Example 4

According to the mass parts, 26 parts of nucleotide, 18 parts of zymosan, 11 parts of glutathione source, 9 parts of stevioside, 6 parts of fructose and 18 parts of Chinese herbal medicine are mixed, wherein the formula of the Chinese herbal medicine is as follows: 30 parts of dwarf lilyturf tuber, 10 parts of dried orange peel, 10 parts of pilose asiabell root, 20 parts of largehead atractylodes rhizome, 20 parts of Indian buead, 15 parts of officinal magnolia bark, 10 parts of malaytea scurfpea fruit and 18 parts of liquoric root, and the traditional Chinese medicine is obtained by mixing, crushing and sieving.

Example 5

According to the mass parts, 26 parts of nucleotide, 16 parts of zymosan, 15 parts of glutathione source, 10 parts of stevioside, 10 parts of fructose and 20 parts of Chinese herbal medicine are mixed, wherein the formula of the Chinese herbal medicine is as follows: 26 parts of dwarf lilyturf tuber, 14 parts of dried orange peel, 12 parts of pilose asiabell root, 15 parts of largehead atractylodes rhizome, 16 parts of Indian buead, 19 parts of officinal magnolia bark, 12 parts of malaytea scurfpea fruit and 17 parts of liquoric root, and the traditional Chinese medicine is obtained by mixing, crushing and sieving.

Example 6

According to the mass parts, 27 parts of baker's yeast extract nucleotide, 16 parts of zymosan, 12 parts of glutathione source, 10 parts of stevioside, 6 parts of fructose and 18 parts of Chinese herbal medicine are added, wherein the formula of the Chinese herbal medicine is as follows: 25 parts of dwarf lilyturf tuber, 13 parts of dried orange peel, 12 parts of pilose asiabell root, 17 parts of largehead atractylodes rhizome, 18 parts of Indian buead, 18 parts of officinal magnolia bark, 12 parts of malaytea scurfpea fruit and 17 parts of liquoric root, and the traditional Chinese medicine is obtained by mixing, crushing and sieving.

Example 7

According to the mass parts, 27 parts of beer yeast extract nucleotide, 16 parts of zymosan, 12 parts of glutathione source, 10 parts of stevioside, 6 parts of fructose and 18 parts of Chinese herbal medicine are added, wherein the formula of the Chinese herbal medicine is as follows: 25 parts of dwarf lilyturf tuber, 13 parts of dried orange peel, 12 parts of pilose asiabell root, 17 parts of largehead atractylodes rhizome, 18 parts of Indian buead, 18 parts of officinal magnolia bark, 12 parts of malaytea scurfpea fruit and 17 parts of liquoric root, and the traditional Chinese medicine is obtained by mixing, crushing and sieving.

Comparative examples

Comparative example 1: the procedure of example 1 was repeated except that glutathione was not added and the same amount of nucleotide was used instead of glutathione.

Comparative example 2: the difference from example 1 was that glutathione was replaced with the same amount of nucleotides without adding zymosan under the same conditions as in example 1.

Comparative example 3: unlike example 1, the amount of nucleotide was reduced to 5 parts, and the remaining 22 parts were replaced with glutathione, under the same conditions as in example 1.

Comparative example 4: different from the embodiment 1, the method does not add compound Chinese herbal medicines, and the other conditions are the same as the embodiment 1.

Comparative example 5: different from the embodiment 1, the bitter orange peel, the white atractylodes rhizome and the officinal magnolia bark in the compound Chinese herbal medicine are removed, and other conditions are the same as the embodiment 1.

Comparative example 6: the nursery pig is fed with the feed with the formula of CN 105124193A.

Comparative example 7: the nursery pig is fed with the feed with the formula of CN 104381718A.

Effects of the embodiment

420 nursery pigs were selected for the trial and randomly divided into the groups of examples 1-7 and comparative examples 1-7, with 3 replicates per group, and 14 piglets per replicate. Examples 1-2 and examples 6-7 and comparative examples 1-7 groups added 400g/t of flavoring agent, 200g/t of sweetener and 500g/t of phagostimulant on the basis of basic ration; in the group of the embodiment 3, 400g/t of flavoring agent and 200g/t of sweetening agent are added on the basis of basic daily ration, and 100g/t of phagostimulant is added in the test group, namely the addition amount of the phagostimulant is reduced; in the groups 4-5, 400g/t of flavoring agent and 200g/t of sweetening agent are added on the basis of basic daily ration, and 500g/t of the phagostimulant is added in the test group. Wherein the basic daily ration contains 4 kg/ton of salt, the test time is 2016 years and 9 months, the test site is a certain pig farm in Fuzhou, and the test period is 7-10 kg. The control group is based on the fact that no phagostimulant is added, and specific data results are shown in table 1.

TABLE 1

As can be seen from the above table, the intake of examples 1-3 was increased to 11%, wherein the intake was increased by the synergistic effect of common salt and nucleotide when a proper amount of common salt was added in example 4, while the intake was decreased by the addition of too much common salt in example 5; wherein the feed intake of the baker's yeast nucleotide extract used in example 6 is more than 18%, and the feed intake of the beer yeast extract used in example 7 is less than 10%; the comparative examples 1 to 4 are all below 10 percent, the comparative examples 6 to 7 are all below 1.23 percent and are all lower than the formula of the invention, wherein, the addition amount of the phagostimulant is reduced and the effect is also reduced in the example 3, and the formula of the compound Chinese herbal medicine has certain influence on the effect in the comparative example 5. The data results in table 1 show that the phagostimulant of the invention has outstanding effect in improving the feed intake of pigs by combining the nucleotide, zymosan, glutathione source, stevioside and fructose and reasonably matching with Chinese herbal medicines.

Variations and modifications to the above-described embodiments may occur to those skilled in the art, which fall within the scope and spirit of the above description. Therefore, the present invention is not limited to the specific embodiments disclosed and described above, and some modifications and variations of the present invention should fall within the scope of the claims of the present invention. Furthermore, although specific terms are employed herein, they are used in a generic and descriptive sense only and not for purposes of limitation.

Claims

1. The pig phagostimulant is characterized by consisting of nucleotide, zymosan, glutathione, sugar and a Chinese herbal medicine compound, wherein the nucleotide is as follows by weight: and (3) yeast polysaccharide: glutathione: sugar: 25-30 parts of Chinese herbal medicine compound: 15-20: 10-15: 10-20: 15-20 parts of; the nucleotide is a baker's yeast extract, and the Chinese herbal medicine compound consists of 20-30 parts of radix ophiopogonis, 10-15 parts of dried orange peel, 10-15 parts of codonopsis pilosula, 15-20 parts of bighead atractylodes rhizome, 15-20 parts of poria cocos, 15-20 parts of mangnolia officinalis, 10-15 parts of fructus psoraleae and 15-20 parts of liquorice in parts by mass, and is crushed and sieved.

2. The phagostimulant of claim 1, wherein the ratio of nucleotides to nucleotides, by weight: and (3) yeast polysaccharide: glutathione: sugar: the Chinese herbal medicine compound is 27: 16: 12: 16: 18.

3. the phagostimulant of claim 1, wherein the sugar comprises stevioside and fructose, and the mass ratio of the stevioside to the fructose is 1-2: 1-2.