CN114558086B - An oral Chinese medicinal composition for the treatment of eczema - Google Patents

An oral Chinese medicinal composition for the treatment of eczema Download PDF

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CN114558086B
CN114558086B CN202210329350.7A CN202210329350A CN114558086B CN 114558086 B CN114558086 B CN 114558086B CN 202210329350 A CN202210329350 A CN 202210329350A CN 114558086 B CN114558086 B CN 114558086B
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CN114558086A (en
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陈宁刚
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Ningbo Traditional Chinese Medicine Hospital
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    • A61K36/00Medicinal preparations of undetermined constitution containing material from algae, lichens, fungi or plants, or derivatives thereof, e.g. traditional herbal medicines
    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/88Liliopsida (monocotyledons)
    • A61K36/894Dioscoreaceae (Yam family)
    • A61K36/8945Dioscorea, e.g. yam, Chinese yam or water yam
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    • A61K35/57Birds; Materials from birds, e.g. eggs, feathers, egg white, egg yolk or endothelium corneum gigeriae galli
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    • A61K35/64Insects, e.g. bees, wasps or fleas
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    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/28Asteraceae or Compositae (Aster or Sunflower family), e.g. chamomile, feverfew, yarrow or echinacea
    • A61K36/284Atractylodes
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/34Campanulaceae (Bellflower family)
    • A61K36/344Codonopsis
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/481Astragalus (milkvetch)
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    • A61K36/18Magnoliophyta (angiosperms)
    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/48Fabaceae or Leguminosae (Pea or Legume family); Caesalpiniaceae; Mimosaceae; Papilionaceae
    • A61K36/484Glycyrrhiza (licorice)
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    • A61K36/185Magnoliopsida (dicotyledons)
    • A61K36/72Rhamnaceae (Buckthorn family), e.g. buckthorn, chewstick or umbrella-tree
    • A61K36/725Ziziphus, e.g. jujube
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    • A61K36/88Liliopsida (monocotyledons)
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    • A61K36/88Liliopsida (monocotyledons)
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Abstract

The invention relates to a traditional Chinese medicine composition for treating eczema, which is prepared from Chinese yam, stir-fried white hyacinth bean, coix seed, codonopsis pilosula, bighead atractylodes rhizome, poria cocos, astragalus mongholicus, stir-fried malt, stir-fried rice sprout, stir-fried chicken's gizzard-membrane, silkworm excrement, chinese date, cicada shell and liquorice. The traditional Chinese medicine composition has reasonable design and mutual compatibility, and has high remission rate of eczema, low recurrence rate and fresh adverse reaction.

Description

An oral Chinese medicinal composition for the treatment of eczema
Technical Field
The invention relates to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine composition for treating eczema.
Background
Eczema is a skin inflammatory reaction which is caused by various complex factors, has obvious exudation tendency and is easy to relapse. Clinically, it is characterized by the skin lesions with polymorphous skin lesions with exudation tendency, marked pruritus, symmetrical distribution and chronic course. Acute erythema, herpes simplex and exudation mainly cause skin dryness, pigmentation and lichenification change. Severe itching, skin damage affecting beauty and repeated illness, seriously affecting the mood and life quality of patients and causing psychosomatic damage. According to statistics, the domestic eczema incidence rate is very high, accounts for 15% -30% of clinical cases of dermatology department, and is in a trend of rising year by year. The pathogenesis of the disease is still unclear in western medicine, the disease is related to various factors inside and outside, and the research focuses at present on the close correlation between the disease and the allergic reaction caused by the immunologic dysfunction in vivo. It has been shown that histamine is one of the important causes for inducing eczema pruritus, and additionally, inflammatory mediators interleukin, leukotriene, tumor necrosis factor, etc. may also cause pruritus. The systemic treatment of western medicines comprises antihistamine, glucocorticoid, immunosuppressant, antimicrobial drug (such as antibiotic), trace elements (such as VC and zinc), biological agent and the like, topical glucocorticoid ointment, calcineurin inhibitor, humectant and the like, and the prior treatment mainly comprises symptomatic treatment, is easy to relapse after drug withdrawal, has large side effect after long-term application of hormones and immunosuppressants, and has high cost of biological agent and long-term side effect of clinical application which are remained to be observed and the like to become a treatment difficulty.
Chronic eczema belongs to the categories of eczema, impetigo, blood-wind sore and the like in traditional Chinese medicine, and is considered by doctors of different generations to be caused by congenital intolerance, spleen dysfunction, and wind, dampness and heat evil obstruction on skin. Or the spleen and stomach are injured due to improper diet, overeating for fat, sweet, thick and greasy food, or the spleen deficiency is not enough due to weak body, so that damp-heat is accumulated in the body, wind evil is caused, and rheumatic heat is soaked in the skin to cause diseases; lingering damp-heat, yin impairment and blood consumption, blood deficiency producing wind and dryness, and loss of nourishment of the skin. Most of the existing traditional Chinese medicine formulas for treating eczema mainly have the effects of clearing heat and promoting diuresis.
The existing traditional Chinese medicines for treating eczema have limited effects, so that medicines applied to treating eczema are further developed from the field of traditional Chinese medicines, richer choices are provided for making clinical medication schemes, and the technical problem to be solved is urgent.
Disclosure of Invention
The invention aims to provide a traditional Chinese medicine composition capable of effectively treating eczema by oral administration.
In order to achieve the purpose, the invention adopts the following technical scheme:
the first aspect of the invention provides a traditional Chinese medicine composition for treating eczema, which is prepared from Chinese yam, stir-fried white hyacinth bean, coix seed, dangshen, bighead atractylodes rhizome, tuckahoe, astragalus root, roasted malt, roasted rice sprout, roasted chicken's gizzard-membrane, silkworm excrement, chinese date, cicada shell and liquorice.
Preferably, the traditional Chinese medicine composition is prepared from 1-10 parts by weight of Chinese yam, 1-10 parts by weight of fried white hyacinth bean, 1-10 parts by weight of coix seed, 1-6 parts by weight of dangshen, 1-6 parts by weight of largehead atractylodes rhizome, 1-6 parts by weight of poria cocos, 1-6 parts by weight of astragalus root, 1-6 parts by weight of fried malt, 1-6 parts by weight of fried rice sprout, 1-6 parts by weight of fried chicken's gizzard-membrane, 1-6 parts by weight of silkworm excrement, 1-6 parts by weight of Chinese date, 0.5-5 parts by weight of periostracum cicadae and 0.5-5 parts by weight of liquorice.
More preferably, the traditional Chinese medicine composition is prepared from 1-6 parts by weight of Chinese yam, 1-6 parts by weight of stir-fried white hyacinth bean, 1-6 parts by weight of coix seed, 1-4 parts by weight of dangshen, 1-4 parts by weight of largehead atractylodes rhizome, 1-4 parts by weight of poria cocos, 1-4 parts by weight of astragalus mongholicus, 1-4 parts by weight of stir-fried malt, 1-4 parts by weight of stir-fried rice sprout, 1-4 parts by weight of stir-fried chicken's gizzard-membrane, 1-4 parts by weight of silkworm excrement, 1-4 parts by weight of Chinese date, 0.5-3 parts by weight of periostracum cicadae and 0.5-3 parts by weight of liquorice.
More preferably, the traditional Chinese medicine composition is prepared from 2-4 parts by weight of Chinese yam, 2-4 parts by weight of stir-fried white hyacinth bean, 2-4 parts by weight of coix seed, 1-3 parts by weight of codonopsis pilosula, 1-3 parts by weight of bighead atractylodes rhizome, 1-3 parts by weight of poria cocos, 1-3 parts by weight of astragalus mongholicus, 1-3 parts by weight of stir-fried malt, 1-3 parts by weight of stir-fried rice sprout, 1-3 parts by weight of stir-fried chicken gizzard membrane, 1-3 parts by weight of silkworm excrement, 1-3 parts by weight of Chinese date, 0.5-2 parts by weight of periostracum cicadae and 0.5-2 parts by weight of liquorice.
Most preferably, the traditional Chinese medicine composition is prepared from 3 parts by weight of Chinese yam, 3 parts by weight of stir-fried white hyacinth bean, 3 parts by weight of coix seed, 2 parts by weight of dangshen, 2 parts by weight of largehead atractylodes rhizome, 2 parts by weight of poria cocos, 2 parts by weight of astragalus membranaceus, 2 parts by weight of stir-fried malt, 2 parts by weight of stir-fried rice sprout, 2 parts by weight of stir-fried chicken's gizzard-membrane, 2 parts by weight of silkworm excrement, 2 parts by weight of Chinese date, 1 part by weight of cicada shell and 1 part by weight of liquorice.
Preferably, the Chinese medicinal composition is in the form of tablets, capsules, powder or decoction. More preferably, the Chinese medicinal composition is in the form of decoction.
The second aspect of the invention provides a preparation method of the traditional Chinese medicine composition for treating eczema, which comprises the following steps: weighing the Chinese yam, the fried white hyacinth bean, the coix seed, the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the astragalus mongholicus, the fried malt, the fried rice sprout, the fried chicken gizzard membrane, the silkworm excrement, the Chinese date, the periostracum cicadae and the liquorice according to the prescription amount, adding 1-10 times of water by weight, decocting and concentrating the mixture to 2-5 times of water by weight, filtering the filtrate, repeating the steps for decocting twice, and combining the two filtrates to obtain the Chinese herbal medicine composition.
Preferably, the preparation method comprises adding 5 times of water by weight, decocting and concentrating to 2 times of water by weight.
The third aspect of the invention is to provide the application of the traditional Chinese medicine composition in preparing a medicine for treating eczema.
Preferably, the eczema is selected from atopic dermatitis, pompholyx, stasis dermatitis or solar dermatitis.
Preferably, the eczema is selected from chronic eczema or acute eczema.
The fourth aspect of the invention is to provide the application of the traditional Chinese medicine composition in preparing medicines for reducing the content of IL-4 in serum.
The fifth aspect of the invention is to provide the application of the traditional Chinese medicine composition in preparing a medicine for improving the content of IFN-gamma and/or CORT in serum.
The common pharmacological effects of the traditional Chinese medicine raw materials selected by the invention in the field are as follows:
the yam, namely the yam, can be eaten by vegetables, is a dried rhizome of the dioscorea opposita of the family dioscoreaceae, is sweet in taste, mild in nature, nontoxic, and capable of entering spleen, stomach and kidney channels, has the effects of tonifying spleen, nourishing stomach, promoting fluid production, benefiting lung, tonifying kidney and controlling nocturnal emission, and is used for treating spleen deficiency, anorexia, chronic diarrhea, lung deficiency, cough and asthma, kidney deficiency, spermatorrhea, leukorrhagia, frequent micturition, deficiency heat and thirst quenching and the like.
The white hyacinth bean, namely black bean and southern hyacinth bean, is edible after being fried, is a dry mature seed of the hyacinth bean of the leguminous hyacinth bean, has sweet taste and mild nature, enters the spleen and stomach meridians, has the effects of tonifying the spleen and stomach, regulating the middle warmer, eliminating dampness, relieving summer heat and detoxifying, is mainly used for treating diseases such as weakness of the spleen and stomach, diarrhea, vomiting, summer-heat and dampness accumulation, abdominal distending pain, red and white leukorrhea and the like, and can also relieve alcoholism.
The Coicis semen, also known as Coicis semen, or Coicis semen, is dry mature seed of Coicis semen of Gramineae, and has cool nature, sweet and light taste. The coix seed can be used for treating edema, beriberi and dysuria, has the effects of promoting diuresis and reducing edema, invigorating spleen and removing dampness, relaxing muscles and tendons and removing arthralgia, clearing heat and expelling pus and the like, is a commonly used diuresis and dampness-excreting medicine, and has good curative effects on keeping the skin of a human body glossy and fine, eliminating acne, freckles, senile plaques, cyasma and butterfly rash, desquamation, acne, rhagadia, rough skin and the like.
The medicinal material of the codonopsis pilosula is dried roots of codonopsis pilosula, codonopsis pilosula vegetarian or codonopsis pilosula from radix of Campanulaceae, and the like, and the codonopsis pilosula is sweet in taste and neutral in nature and enters spleen and lung channels. Has effects of invigorating spleen, replenishing qi, invigorating spleen, benefiting lung, nourishing blood, and promoting fluid production. Can be used for treating deficiency of spleen-lung qi, anorexia, listlessness, cough, asthma, deficiency of qi and blood, sallow complexion, palpitation, short breath, thirst due to body fluid consumption, internal heat, and diabetes.
Atractylodes macrocephala Koidz belonging to Compositae,Atractylodes genusPerennial herbaceous plants are used as medicines by using rhizomes. Bitter and sweet in taste and warm in nature. It enters spleen and stomach meridians. The rhizoma atractylodis macrocephalae has the effects of strengthening spleen and tonifying qi, eliminating dampness and promoting diuresis, arresting sweating and preventing miscarriage, and is used for treating spleen deficiency and anorexia, abdominal distension and diarrhea, phlegm and fluid retention and dizziness and palpitation, edema, spontaneous perspiration and threatened abortion.
Poria, a dried sclerotium of Poria cocos (a fungus of Polyporaceae), is sweet and light in flavor, neutral in nature, and enters heart, spleen, and kidney meridians. Has effects of promoting diuresis, eliminating dampness, invigorating spleen, regulating stomach function, calming heart, and tranquilizing mind, and can be used for treating dysuresia, edema, distention, phlegm retention, cough, anorexia, epigastric distress, constipation, diarrhea, giddiness, cardiopalmus, insomnia, nocturnal emission, turbid urine, dribbling urination, leukorrhagia, etc.
Astragalus membranaceus, also called "Astragalus membranaceus", is a well-known good medicine for invigorating qi, has a strengthening effect on human body, is the root of Astragalus membranaceus bge or Astragalus membranaceus bge of Leguminosae, is warm in nature and sweet in flavor, and has the functions of invigorating qi, invigorating yang, consolidating superficial resistance, arresting sweating, expelling pus, promoting granulation, relieving swelling and inducing diuresis. It can be used for treating spontaneous perspiration due to asthenia, internal injury due to overstrain, loose stool, diarrhea, edema due to qi deficiency, carbuncle, cellulitis, and skin ulcer.
Roasted malt, also known as tiller, is the mature fruit of barley of the grass family, and is processed through germination and drying, sweet and neutral in taste, and enters spleen and stomach meridians. Has the functions of promoting qi circulation to promote digestion, strengthening spleen to stimulate appetite, stopping lactation and relieving distension. Can be used for treating dyspepsia, abdominal pain, spleen deficiency, anorexia, breast pain, breast milk loss, hypochondriac pain due to stagnation of liver-qi, and pain of liver and stomach. Parched fructus Hordei Germinatus has effects of activating qi-flowing, resolving food stagnation and promoting lactation, and can be used for treating indigestion and lactation interruption of women.
The fried rice sprout, also called rice sprout, is a processing product of mature fruit of the millet of the Gramineae after sprouting and drying, has sweet taste and mild nature, enters spleen and stomach channels, has the effects of strengthening spleen and stimulating appetite, promoting digestion and regulating the middle warmer, and is used for treating indigestion and indigestion, gastric distress and abdominal distension, chronic diarrhea, inappetence and beriberi edema.
Endothelium corneum Gigeriae Galli, also known as endothelium corneum Gigeriae Galli, is the inner wall of dry sand sac of chicken of Phasianidae, has sweet taste and neutral nature, and has effects of invigorating stomach, resolving food stagnation, astringing essence, stopping nocturnal emission, and treating stranguria and fossil, and can be used for treating dyspepsia, emesis, dysentery, infantile malnutrition, enuresis, nocturnal emission, stranguria with calculus, gallbladder distention, and hypochondriac pain. The endothelium corneum Gigeriae Galli has crisp texture, is easy to pulverize, and can enhance the effects of invigorating spleen and resolving food stagnation, and can be used for treating dyspepsia, indigestion, liver deficiency diarrhea and infantile malnutrition.
Silkworm excrement, also known as silkworm excrement, is dry excrement of silkworms, sweet and pungent in flavor, warm in nature, and enters liver, spleen and stomach meridians. Has effects of dispelling pathogenic wind, removing dampness, regulating stomach function, eliminating turbid pathogen, promoting blood circulation, and relieving pain, and can be used for treating rheumatalgia, headache due to wind evil, cholera, emesis, diarrhea, spasm, abdominal pain, skin pruritus, urticaria, and trachoma.
Fructus Jujubae, also known as fructus Jujubae, is the mature fruit of Rhamnaceae deciduous shrub or small arbor plant, is sweet and warm in taste, and enters spleen and stomach meridians. The Chinese date has the effects of tonifying middle-jiao and Qi, nourishing blood and soothing nerves, and is used for treating weakness of the spleen and the stomach, anorexia, loose stool, fatigue, deficiency of qi and blood, palpitation, allergic purpura and irritability of women, relieving the toxicity of drastic medicaments and reducing side effects.
Periostracum Cicadae, also called periostracum Cicadae, is the peel shell which falls off when the larva of the cicada family insect black is eclosized, and is salty, sweet and cold in nature; enter lung and liver meridians. Has effects of dispelling wind heat, dispersing lung qi, promoting eruption, and relieving spasm, and can be used for treating wind heat common cold, cough, hoarseness, sore throat, measles without eruption, rubella, infantile convulsion and epilepsy, night cry, tetanus, conjunctival congestion, and nebula.
The licorice, also called Meicao and Gulao, is a dry product of root and rhizome of medicinal plant licorice, has sweet taste and mild nature, enters heart, lung, spleen and stomach channels, and has the effects of clearing away heat and toxic materials, relieving cough and eliminating phlegm, tonifying spleen and stomach and harmonizing the drugs. The Glycyrrhrizae radix contains glycyrrhizin, glycyrrhizin and hormone-like components, and has adrenocortical hormone-like effect and antiinflammatory, antiallergic, antitumor, antibacterial, antitussive, expectorant, toxic substance removing and antiulcer effects.
The invention has the positive and beneficial effects that:
1. the traditional Chinese medicine composition provided by the invention adopts natural traditional Chinese medicine raw materials, is simple in preparation method, wide in raw material medicine source, low in cost, free of hormone stimulation toxic and side effects, and suitable for long-term administration of eczema patients.
2. The traditional Chinese medicine composition provided by the invention is scientific and reasonable in compatibility and formula, each raw material medicine has different functions and supplements each other, and has high remission rate and low recurrence rate on eczema, and has fresh adverse reactions.
Detailed Description
The present invention will be further described with reference to the following examples, but the embodiments of the present invention are not limited thereto. The experimental procedures used in the following examples are all conventional procedures unless otherwise specified.
Example 1
Respectively weighing 3 parts by weight of Chinese yam, 3 parts by weight of fried white hyacinth bean, 3 parts by weight of coix seed, 2 parts by weight of dangshen, 2 parts by weight of largehead atractylodes rhizome, 2 parts by weight of tuckahoe, 2 parts by weight of astragalus root, 2 parts by weight of fried malt, 2 parts by weight of fried rice sprout, 2 parts by weight of fried chicken's gizzard-membrane, 2 parts by weight of silkworm excrement, 2 parts by weight of Chinese date, 1 part by weight of cicada shell and 1 part by weight of liquorice, adding 5 times of water by weight, decocting and concentrating to 2 times of water by weight, filtering the filtrate, repeating the steps for twice, and combining the two filtrates to obtain the traditional Chinese medicine composition 1.
Example 2
Respectively weighing 2 parts by weight of Chinese yam, 2 parts by weight of stir-fried white hyacinth bean, 2 parts by weight of coix seed, 3 parts by weight of dangshen, 3 parts by weight of largehead atractylodes rhizome, 3 parts by weight of tuckahoe, 2 parts by weight of astragalus root, 2 parts by weight of stir-fried malt, 2 parts by weight of stir-fried rice sprout, 2 parts by weight of stir-fried chicken's gizzard-membrane, 2 parts by weight of silkworm excrement, 2 parts by weight of Chinese date, 1 part by weight of cicada shell and 1 part by weight of liquorice, adding 5 times of water by weight, decocting and concentrating to 2 times of water by weight, filtering the filtrate, repeating the steps for two times of decoction, and combining the two filtrates to obtain the traditional Chinese medicine composition 2.
Example 3
Respectively weighing 2 parts by weight of Chinese yam, 2 parts by weight of stir-fried white hyacinth bean, 2 parts by weight of coix seed, 2 parts by weight of dangshen, 2 parts by weight of largehead atractylodes rhizome, 2 parts by weight of tuckahoe, 3 parts by weight of astragalus root, 3 parts by weight of stir-fried malt, 3 parts by weight of stir-fried rice sprout, 2 parts by weight of stir-fried chicken's gizzard-membrane, 2 parts by weight of silkworm excrement, 2 parts by weight of Chinese date, 1 part by weight of cicada shell and 1 part by weight of liquorice, adding 5 times of water by weight, decocting and concentrating to 2 times of water by weight, filtering the filtrate, repeating the steps for two times of decoction, and combining the two filtrates to obtain the traditional Chinese medicine composition 3.
Example 4
Respectively weighing 2 parts by weight of Chinese yam, 2 parts by weight of stir-fried white hyacinth bean, 2 parts by weight of coix seed, 2 parts by weight of dangshen, 2 parts by weight of largehead atractylodes rhizome, 2 parts by weight of tuckahoe, 2 parts by weight of astragalus root, 2 parts by weight of stir-fried malt, 2 parts by weight of stir-fried rice sprout, 3 parts by weight of stir-fried chicken's gizzard-membrane, 3 parts by weight of silkworm excrement, 3 parts by weight of Chinese date, 1 part by weight of cicada shell and 1 part by weight of liquorice, adding 5 times of water by weight, decocting and concentrating to 2 times of water by weight, filtering the filtrate, repeating the steps for two times of decoction, and combining the two filtrates to obtain the traditional Chinese medicine composition 4.
Comparative example 1 (silkworm excrement omitted)
Respectively weighing 3 parts by weight of Chinese yam, 3 parts by weight of stir-fried white hyacinth bean, 3 parts by weight of coix seed, 2 parts by weight of dangshen, 2 parts by weight of largehead atractylodes rhizome, 2 parts by weight of tuckahoe, 2 parts by weight of astragalus root, 2 parts by weight of stir-fried malt, 2 parts by weight of stir-fried rice sprout, 4 parts by weight of stir-fried chicken's gizzard-membrane, 2 parts by weight of Chinese date, 1 part by weight of cicada shell and 1 part by weight of liquorice, adding 5 times of water by weight, decocting and concentrating to 2 times of water by weight, filtering the filtrate, repeating the steps for two times of decoction, and combining the two filtrates to obtain the comparative example 1 of the traditional Chinese medicine composition.
COMPARATIVE EXAMPLE 2 (omitting endothelium corneum Gigeriae Galli)
Respectively weighing 3 parts by weight of Chinese yam, 3 parts by weight of stir-fried white hyacinth bean, 3 parts by weight of coix seed, 2 parts by weight of dangshen, 2 parts by weight of largehead atractylodes rhizome, 2 parts by weight of tuckahoe, 2 parts by weight of astragalus root, 2 parts by weight of stir-fried malt, 2 parts by weight of stir-fried rice sprout, 4 parts by weight of silkworm excrement, 2 parts by weight of Chinese date, 1 part by weight of cicada shell and 1 part by weight of liquorice, adding 5 times of water by weight, decocting and concentrating the mixture to 2 times of water by weight, filtering the filtrate, repeating the steps for decocting twice, and combining the two filtrates to obtain the comparative example 2 of the traditional Chinese medicine composition.
Comparative example 3 (replacing silkworm excrement and fried chicken's gizzard-membrane with dried orange peel)
Respectively weighing 3 parts by weight of Chinese yam, 3 parts by weight of stir-fried white hyacinth bean, 3 parts by weight of coix seed, 2 parts by weight of dangshen, 2 parts by weight of largehead atractylodes rhizome, 2 parts by weight of tuckahoe, 2 parts by weight of astragalus root, 2 parts by weight of stir-fried malt, 2 parts by weight of stir-fried rice sprout, 4 parts by weight of tangerine peel, 2 parts by weight of Chinese date, 1 part by weight of cicada shell and 1 part by weight of liquorice, adding 5 times of water by weight, decocting and concentrating to 2 times of water by weight, filtering the filtrate, repeating the steps for two times of decoction, and combining the two filtrates to obtain the comparative traditional Chinese medicine composition 3.
Test example 1 therapeutic effect of the Chinese medicinal composition of the present invention on eczema mouse model
1. Test method
1.1 establishment of animal model
Depilatory cream is used for depilating rat back skin, and the depilatory area is 4cm × 4cm, and is divided into A, B. Sensitization was carried out by sucking 100. Mu.L of a 7% -DNCB acetone solution uniformly applied to the skin at A with a pipette gun. After 1 week, the skin was challenged by applying 5% DNCB acetone solution 50. Mu.L to B, once every 5 days, 4 times in succession. After the stimulation, the skin on the back B of the rat gradually appears erythema, pimple, scratch, scale, scabbing and moss-like change, and the model conforms to the diagnosis standard of eczema, which indicates that the model is successfully copied.
1.2 animal grouping and administration
Taking the traditional Chinese medicine composition solutions prepared in the examples 1-4 and the comparative examples 1-3 respectively, heating and concentrating to obtain extractum with the relative density of 1.20, and adding distilled water into each traditional Chinese medicine extractum to prepare 400mg/ml intragastric administration liquid medicine for later use.
After the rats are fed with basal feed adaptively for one week, the rats are randomly divided into 9 groups, namely a blank group, a model group, 10 groups of the traditional Chinese medicine composition of the invention of examples 1-4 and a comparative example of the traditional Chinese medicine composition of 1-3, and are fed in cages. Except for the blank group and the model group, the groups of examples 1 to 4 of the present invention and the groups of comparative examples 1 to 3 were each gavaged at a dose of 1ml/100g body weight for 10 days with 1 time per day.
1.3 determination of IFN-. Gamma., IL-4 and CORT (Cort Ketone) in serum
After the last administration, rats in each group are fasted without water prohibition, after 12 hours, the rats are anesthetized by ether, blood is taken from abdominal aorta, centrifugation is carried out for 20min at 2500r/min, serum is taken, IFN-gamma, IL-4 and CORT in the serum of rats in each group are measured by adopting an ELISA method, and the method is operated according to the kit specification.
2. Test results
After 10 days of administration of the Chinese medicinal composition for treating eczema in model rats, the changes of IFN-gamma, IL-4 and CORT levels in the serum of the model rats are shown in Table 1.
TABLE 1 comparison of IFN-. Gamma.IL-4 and CORT levels in rat serum after administration of each of the Chinese medicinal compositions
Figure BDA0003574649600000071
As can be seen from the above table 1, compared with the blank group, the levels of INF-gamma and CORT in the serum of the rat in the model group are obviously reduced, and the level of IL-4 is obviously increased; compared with a model group, the contents of INF-gamma and CORT in the serum of rats in the example 1-4 groups and the comparative example 1-3 groups of the traditional Chinese medicine composition are increased, and the content of IL-4 is reduced, wherein the contents of INF-gamma and CORT in the serum of rats in the example 1-4 groups are obviously higher than those in the comparative example 1-3 groups, and the content of IL-4 is obviously lower than those in the comparative example 1-3 groups (the difference between before and after use has statistical significance), so that the traditional Chinese medicine composition has a remarkable effect on the treatment of eczema. It is noted that the treatment effect of the group of the Chinese medicinal composition example 1 was the best, resulting in an unexpected technical effect.
Test example 2 clinical test cases
The decoction of the Chinese medicinal composition for treating eczema by oral administration has definite clinical curative effect, and after a large number of patients take the decoction clinically, the symptoms of skin damage severity, area, pruritus and the like can be effectively relieved.
Case 1: when a woman is 19 years old, the patient is diagnosed with allergic rhinitis and has been treated irregularly because of generalized redness, rash, erythema, dryness and pruritus of the skin for 2 years, and the patient has been diagnosed with atopic dermatitis. Loratadine tablet (10 mg/time, 1 time/day) is taken orally, mometasone furoate ointment (1 time/day) is used for treating skin damage, the skin damage is light and heavy, and the disease is not cured repeatedly, after the doctor visits, the traditional Chinese medicine composition decoction of the embodiment 1 of the application is taken orally, 200ml is taken each time, 2 times a day, 4 weeks are needed, and the red rash, the erythema and the pruritus of the whole body are basically eliminated.
Case 2: when one woman is in age 6, the woman is diagnosed with recurrent red rash, pimple, nodule and itching of the whole body for 1 year, accompanied with allergic blepharitis and dry skin, and the mother has a history of eczema, which was once diagnosed as atopic dermatitis. The mometasone furoate ointment (1 time/day) and the tacrolimus ointment (0.03%) are intermittently and externally applied for a long time (2 times/day), the loratadine tablet (5 mg/time and 1 time/day) is orally taken, the skin damage is not cured repeatedly, the traditional Chinese medicine composition decoction in the embodiment 1 of the application is taken orally after a doctor visits, the dosage is 100ml each time, 2 times a day, and 4 weeks are totally, and the erythema, pimple, nodule and pruritus of the whole body are basically eliminated.
Case 3: somebody in sun, female, 20 years old, was diagnosed with "pompholyx" because of herpes, blister, itching in both palms and soles for 3 months. Externally applied halometasone ointment (2 times/day), orally taken cetirizine tablets (10 mg/time and 1 time/day) and the like, the skin damage is repeated, the traditional Chinese medicine composition decoction of the application example 1 is applied after the doctor visits, 200ml is applied every time, 2 times a day for 4 weeks, the herpes zoster of hands and feet and pruritus are basically eliminated, and mild desquamation is remained.
Case 4: in certain forest, women in age 72, the disease is diagnosed as stasis dermatitis due to dark reddish spot rash, deep color and itching of the right lower leg for 1 year, accompanied by superficial varicose vein of the right lower limb. Externally applied halometasone ointment (2 times per day), orally taken desloratadine citrate disodium tablets (10 mg/time and 1 time per day) and the like, the skin damage is repeated, the traditional Chinese medicine composition decoction of the application example 1 is applied after the doctor visits, 200ml is applied every time, 2 times per day is carried out, 4 weeks are total, the erythema and pruritus of the right lower leg are basically eliminated, and the color is remained.
Case 5: when a certain Liu is in age 63, the disease is diagnosed as solar dermatitis because the face and the back of the hand are repeatedly red rash, deep color and pruritus for 1 year and the disease is aggravated after the sun exposure, and the disease is diagnosed as negative of autoantibody. The skin damage is not cured repeatedly by externally applying 0.03% tacrolimus ointment (2 times per day) and orally taking loratadine tablets (10 mg/time and 1 time per day) for a long time discontinuously, the traditional Chinese medicine composition decoction of the embodiment 1 of the application is applied and orally taken after the doctor visits, 200ml is taken each time, 2 times per day, 4 weeks are totally, the red rash and the pruritus of the face and the back of the hand basically disappear, and the remained color is not faded.
The cautions in treatment are as follows:
1. the fresh and cold fruits, the sweet and greasy food, the spicy stimulation food, the seafood, the chicken, the dog, the cattle, the sheep and the goose are not eaten, the easily digestible food is eaten by warm drinking, and the fresh vegetables are eaten more.
2. Topical moisturizing lotions are often used for topical skin dryness.
3. The patient takes exercise properly in the morning and takes a rest before 10 o' clock in the evening, and the patient suffering from solar dermatitis is prevented from being exposed to the sun.
It is to be understood that the above-described embodiments of the present invention are merely illustrative of or explaining the principles of the invention and are not to be construed as limiting the invention. Therefore, any modification, equivalent replacement, improvement and the like made without departing from the spirit and scope of the present invention should be included in the protection scope of the present invention.

Claims (5)

1. A traditional Chinese medicine composition for treating eczema is characterized by being prepared from 3 parts by weight of Chinese yam, 3 parts by weight of stir-fried white hyacinth bean, 3 parts by weight of coix seed, 2 parts by weight of codonopsis pilosula, 2 parts by weight of bighead atractylodes rhizome, 2 parts by weight of poria cocos, 2 parts by weight of astragalus mongholicus, 2 parts by weight of stir-fried malt, 2 parts by weight of stir-fried rice sprout, 2 parts by weight of stir-fried chicken's gizzard-membrane, 2 parts by weight of silkworm excrement, 2 parts by weight of Chinese date, 1 part by weight of periostracum cicadae and 1 part by weight of liquorice.
2. The traditional Chinese medicine composition of claim 1, wherein the dosage form of the traditional Chinese medicine composition is tablet, capsule, powder or decoction.
3. The method for preparing the traditional Chinese medicine composition of claim 1, which is characterized by comprising the following steps: weighing the Chinese yam, the fried white hyacinth bean, the coix seed, the codonopsis pilosula, the bighead atractylodes rhizome, the poria cocos, the astragalus mongholicus, the fried malt, the fried rice sprout, the fried chicken gizzard membrane, the silkworm excrement, the Chinese date, the periostracum cicadae and the liquorice according to the prescription amount, adding 1-10 times of water by weight, decocting and concentrating the mixture to 2-5 times of water by weight, filtering the filtrate, repeating the steps for decocting twice, and combining the two filtrates to obtain the Chinese herbal medicine composition.
4. The preparation method of the traditional Chinese medicine composition according to claim 3, wherein the preparation method comprises the steps of adding 5 times of water by weight, and decocting and concentrating the mixture to 2 times of water by weight.
5. Use of a Chinese medicinal composition according to any one of claims 1-2 in the manufacture of a medicament for the treatment of eczema.
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