CN114557986A - 一种姜黄组合物及其制备方法与在罗非鱼养殖上的应用 - Google Patents
一种姜黄组合物及其制备方法与在罗非鱼养殖上的应用 Download PDFInfo
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Abstract
本发明涉及淡水渔业养殖技术领域,具体公开了一种姜黄组合物及其制备方法与在罗非鱼养殖上的应用。本发明的姜黄组合物,包括姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素,所述姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素的质量比为(1‑3):(4‑6):(1‑3)。将本发明的姜黄素组合物添加到罗非鱼的基础饲料中可以有效提高罗非鱼对血糖的利用率,同时可以促进罗非鱼生长、提高抗氧化和免疫能力和/或保护肝脏。在提高罗非鱼生长以及降血糖方面具有良好的应用前景。
Description
技术领域
本发明涉及淡水渔业养殖技术领域,具体地说,涉及一种姜黄组合物及其制备方法与在罗非鱼养殖上的应用。
背景技术
近年来罗非鱼因其肉呈白色、刺少、易切片、无臭等优势越来越被市场接受,养殖罗非鱼也成为了一个热门的项目。糖类是鱼类饲料中重要的能源物质。然而与哺乳动物相比,鱼类胰岛素不足、胰岛素受体少以及鱼类对胰岛素抵抗,导致鱼类先天对糖的利用能力差,适宜的饲料碳水化合物水平一般低于20%,被认为是天生的“糖尿病患者”。摄食高糖饲料容易引发餐后高血糖症,危害鱼体健康,同时也限制了糖在饲料中的应用。采用营养调控手段增加鱼类对糖的耐受能力,有利于提高糖的利用效率,节约蛋白质资源。
姜黄素是一种源自中药姜黄的多酚类化合物,具有抗菌、抗炎、抗氧化等多种药理性作用,被广泛的用于医药、食品添加剂等行业。姜黄素有抑制肝胆病变,提高机体免疫力、清除自由基等作用。同时有诸多动物实验研究显示姜黄素具有降血糖、降血脂等生物学活性,展示了其在预防和治疗糖尿病及其并发症方面的治疗潜力。但现有产品的功效仍有待进一步提升、完善。
发明内容
针对现有技术的问题,本发明的目的之一是提供一种可提高罗非鱼对血糖的利用率,并促进其生长、保护其肝脏的组合物。
为了实现该目的,本发明的技术方案如下:
一种姜黄组合物,包括姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素,所述姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素的质量比为(1-3):(4-6):(1-3)。
优选,所述姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素的质量比为3:4:3。
本发明研究发现,当将姜黄素与脱甲氧基姜黄素和双脱甲氧基姜黄素进行特定组合搭配后,可使获得的组合物具有良好的提高罗非鱼对血糖的利用率、促进其生长和保护其肝脏的效果。
本发明所述的姜黄组合物的原料中,姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素三种成分可分别通过本领域常规方法(如,溶剂提取物法,提取溶剂选自乙酸乙酯、异丙醇、正己烷、乙醇、二氯甲烷等)提取姜科、天南星科中的一些植物根茎获得。例如,所述植物可以是郁金块根、姜黄根茎、莪术根茎和天南星科植物菖蒲根茎等。优选从上述姜科植物的根茎,或根茎的其它加工形式,或姜黄粉提取获得。所述根茎的其它加工形式,包括但不限于姜黄浸膏,或姜黄树脂。所述姜黄粉是指经粉碎处理后的姜黄根茎粉末。
本发明的姜黄组合物,还包括姜黄衍生物,所述姜黄衍生物为八氢姜黄素。
本发明中,所述姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素的总质量与所述姜黄衍生物的质量比为(1-3):3,优选为2:3。
本发明的姜黄组合物,还包括木脂素类似物和载体,所述木脂素类似物为苯丙素低聚物;所述载体为稻壳粉、二氧化硅和石粉中一种或两种。
本发明中,苯丙素低聚物的分子量为240.2-630.9。
进一步地,在本发明组合物中加入八氢姜黄素和苯丙素低聚物,可更好地保证方案效果。
本发明的姜黄组合物包括:姜黄素1-5份,脱甲氧基姜黄素2-8份,双脱甲氧基姜黄素2-6份,姜黄衍生物10-15份,木脂素类似物10-25份,载体30-60份;
优选,包括:姜黄素3份,脱甲氧基姜黄素4份,双脱甲氧基姜黄素3份,姜黄衍生物15份,木脂素类似物25份,载体50份。
本发明另提供一种制备上述姜黄组合物的方法,其包括将各组分进行混合的步骤。
本发明还提供一种饲料,其包括上述姜黄组合物。优选,所述姜黄组合物在饲料中的添加量为300±50mg/kg,可既节约成本,又发挥理想的综合效果。
作为一个具体实施方式,本发明的饲料中的基础组分每百克含:豆粕8-9份,鱼粉60-65份,面粉15-20份,玉米蛋白粉2-4份,大豆油2-4份,玉米油2-4份,氯化胆碱0.08-0.12份,磷酸二氢钙2-3份,预混料0.8-1.2份。
每公斤预混料含:
(矿物盐)MgSO4,20g;FeSO4·7H2O,20g;ZnSO4·7H2O,2g;MnSO4·H2O,2g;CuSO4·5H2O,4g;KAl(SO4)2·12H2O,0.6g;KCl,64g;CoCl2·6H2O,0.4g;KI,0.6g;(维生素)VA,70万IU;VD3,35万IU;VK,3.5g;VE,16g;VB1,3.5g;VB2,7g;VB6,7g;VB12,0.007g;生物素,0.03g;叶酸,1.6克;烟酸,35克;Ca-D-泛酸盐,16g;肌醇,35克;淀粉,756.52g。
其营养指标为:水分8.91~9.74%,粗蛋白43.89~44.38%,粗脂肪12.19~12.76%,粗灰分20.15~20.71%。
本发明再提供一种上述姜黄组合物,或上述方法制备得到的姜黄组合物,或上述饲料在提高罗非鱼血糖利用率、提高抗氧化和免疫能力、促进生长和/或保护肝脏中的应用。
本发明的有益效果至少在于:
将本发明的姜黄组合物添加到罗非鱼的饲料中,能够提高提高罗非鱼对血糖的利用率,同时在一定程度上促进罗非鱼的生长,抑制肝脏病变,提高鱼体抗氧化和免疫能力,具有良好的应用前景。
具体实施方式
下面将结合实施例对本发明的优选实施方式进行详细说明。需要理解的是以下实施例的给出仅是为了起到说明的目的,并不是用于对本发明的范围进行限制。本领域的技术人员在不背离本发明的宗旨和精神的情况下,可以对本发明进行各种修改和替换。
下述实施例中所使用的实验方法如无特殊说明,均为常规方法。下述实施例中所用的材料、试剂等,如无特殊说明,均可从商业途径得到或按本领域常规方法制备。
本发明具体实施方式部分所记载的八氢姜黄素、单氧代型姜黄衍生物、苯丙素低聚物、杂木脂素均根据文献中提供的制备方法制得。
具体八氢姜黄素的制备方法可参考UEHARA,SHIN-ICHI,YASUDA,etal.Diarylheptanoids from the Rhizomes of Curcuma xanthorrhiza and Alpiniaofficinarum(Pharmacognosy,Chemical)[J].Chemical&pharmaceutical bulletin,1987,35(8):3298-3304;其化学名称为:1,7-bis(4-hydroxy-3-methoxyphenyl)-heptane-3,5-diol;
单氧代型姜黄衍生物的制备方法可参考Lee K S,Li G,Kim S H,etal.Cytotoxic Diarylheptanoids from the Roots of Juglans mandshurica[J].Journal of Natural Products,2002,65(11):1707-1708,Experimental Section的第5段(Compound 2);
苯丙素低聚物的制备方法可参考Sabrin M S,Selenge E,Takeda Y,etal.Isolation and evaluation of virucidal activities of flavanone glycosidesand rosmarinic acid derivatives from Dracocephalum spp.against felinecalicivirus[J].Phytochemistry,2021,191:112896,4.3.Extraction and isolation;
杂木脂素的制备方法可参考Liu Y,Yang Y,Shumaila T,et al.Lignans fromTujia Ethnomedicine Heilaohu:Chemical Characterization and Evaluation ofTheir Cytotoxicity and Antioxidant Activities[J].Molecules,2018,23(9):2147,3.3.Experimental Procedures。
本发明具体实施方式部分所记载的普通日粮的具体配方和营养成分见表1。其中每公斤预混料含:
(矿物盐)MgSO4,20g;FeSO4·7H2O,20g;ZnSO4·7H2O,2g;MnSO4·H2O,2g;CuSO4·5H2O,4g;KAl(SO4)2·12H2O,0.6g;KCl,64g;CoCl2·6H2O,0.4g;KI,0.6g;(维生素)VA,70万IU;VD3,35万IU;VK,3.5g;VE,16g;VB1,3.5g;VB2,7g;VB6,7g;VB12,0.007g;生物素,0.03g;叶酸,1.6克;烟酸,35克;Ca-D-泛酸盐,16g;肌醇,35克;淀粉,756.52g。
表1
项目 | 含量(%) | 营养指标 | 水平(%) |
豆粕 | 8.4 | 水分 | 9.25 |
鱼粉 | 61.00 | 粗蛋白 | 44.11 |
面粉 | 18.00 | 粗脂肪 | 12.51 |
玉米蛋白粉 | 3.00 | 粗灰分 | 20.51 |
大豆油 | 3.00 | ||
玉米油 | 3.00 | ||
氯化胆碱 | 0.10 | ||
磷酸二氢钙 | 2.50 | ||
预混料 | 1.00 | ||
合计 | 100.00 |
实施例1
本实施例提供一种组合物,其由如下重量份组分组成:姜黄素2份,脱甲氧基姜黄素5份,双脱甲氧基姜黄素3份,八氢姜黄素15份,苯丙素低聚物15份,稻壳粉43份。将所有组分按比例称取并混合均匀,备用。
本实施例进一步提供一种饲料,其中含有普通日粮和上述的组合物,其中组合物占饲料总质量的0.03%。在制备时,将上述组合物添加到饲料中,混合均匀,即得。
实施例2
本实施例提供一种组合物,其由如下重量份组分组成:姜黄素1份,脱甲氧基姜黄素6份,双脱甲氧基姜黄素3份,八氢姜黄素15份,苯丙素低聚物25份,稻壳粉50份。将所有组分按比例称取并混合均匀,备用。
本实施例进一步提供一种饲料,其中含有普通日粮和上述的组合物,其中组合物占饲料总质量的0.03%。在制备时,将上述组合物添加到饲料中,混合均匀,即得。
实施例3
本实施例提供一种组合物,其由如下重量份组分组成:姜黄素3份,脱甲氧基姜黄素4份,双脱甲氧基姜黄素3份,八氢姜黄素15份,苯丙素低聚物25份,稻壳粉50份。将所有组分按比例称取并混合均匀,备用。
本实施例进一步提供一种饲料,其中含有普通日粮和上述的组合物,其中组合物占饲料总质量的0.03%。在制备时,将上述组合物添加到饲料中,混合均匀,即得。
对比例1
本对比例提供一种组合物,其由如下重量份组分组成:姜黄素7份,脱甲氧基姜黄素2份,双脱甲氧基姜黄素1份,八氢姜黄素15份,苯丙素低聚物25份,稻壳粉50份。将所有组分按比例称取并混合均匀,备用。
本对比例进一步提供一种饲料,其中含有普通日粮和上述的组合物,其中组合物占饲料总质量的0.03%。在制备时,将上述组合物添加到饲料中,混合均匀,即得。
对比例2
本对比例提供一种组合物,其由如下重量份组分组成:姜黄素3份,脱甲氧基姜黄素4份,双脱甲氧基姜黄素3份,单氧代型姜黄衍生物15份,苯丙素低聚物25份,稻壳粉50份。将所有组分按比例称取并混合均匀,备用。
本对比例进一步提供一种饲料,其中含有普通日粮和上述的组合物,其中组合物占饲料总质量的0.03%。在制备时,将上述组合物添加到饲料中,混合均匀,即得。
对比例3
本对比例提供一种组合物,其由如下重量份组分组成:姜黄素3份,脱甲氧基姜黄素4份,双脱甲氧基姜黄素3份,八氢姜黄素8份,苯丙素低聚物25份,稻壳粉57份。将所有组分按比例称取并混合均匀,备用。
本对比例进一步提供一种饲料,其中含有普通日粮和上述的组合物,其中组合物占饲料总质量的0.03%。在制备时,将上述组合物添加到饲料中,混合均匀,即得。
对比例4
本对比例提供一种组合物,其由如下重量份组分组成:姜黄素3份,脱甲氧基姜黄素4份,双脱甲氧基姜黄素3份,八氢姜黄素15份,杂木脂素25份,稻壳粉50份。将所有组分按比例称取并混合均匀,备用。
本对比例进一步提供一种饲料,其中含有普通日粮和上述的组合物,其中组合物占饲料总质量的0.03%。在制备时,将上述组合物添加到饲料中,混合均匀,即得。
实验例1
本实验例对上述实施例和对比例制备获得的饲料的性能进行测试。具体如下:
1、试验设计
1.1、试验动物
健康罗非鱼,平均规格为4.48±0.03g。试验平均分成8组,试验1组-试验3组依次分别使用实施例1-实施例3中的饲料,对照组饲喂普通日粮,其余试验组分别使用对比例1-4中的饲料。同时不采取其他防疫措施,其他饲养环境一致。每组设3个平行,每个平行养殖30尾鱼。
1.2试验管理
每天分别与8:30和16:30投喂2次,每次投喂持续30min以上,表现为不再进食后停止投喂。养殖周期为8周。
2、试验方法
2.1姜黄组合物对罗非鱼血糖的影响
饲喂结束后(饲养试验第8周结束后),进行采血,利用南京建成生物公司生产的酶活测试盒测定鱼体组织中血糖含量,比较分析饲料中添加姜黄组合物对鱼体血糖的影响。
2.2姜黄组合物对罗非鱼生长的影响
在饲养结束后(饲养试验第8周结束后),取样分析姜黄组合物对罗非鱼的生长的影响情况。
具体方法为:在饲喂结束后,分别从每个试验组水族箱内取30尾,对每组罗非鱼进行称重,分别计算增重率、特定生长率、饲料转换率(饲料系数),以此评估姜黄组合物对罗非鱼生长性能的效果。
各项指标计算公式如下:
增重率(WGR)=100%×(末重-初重)/初重
特定生长率(SGR)=100%×(Ln末重-Ln初重)/实验天数
饲料转换率(FCR)=饲料消耗量(g)/(末重+死鱼体重-初重)
其中,死鱼体重是指:试验过程中死亡的鱼的末重。本实验例中,没有出现死淘情况。
2.3姜黄组合物对罗非鱼肝脏的影响
饲喂结束后(饲养试验第8周结束后),分别采用南京建成公司的谷草转氨酶(AST)和谷丙转氨酶(ALT)试剂盒测定罗非鱼肝功能指标(谷草转氨酶(AST)和谷丙转氨酶(ALT))。
2.4姜黄组合物对罗非鱼抗氧化、免疫性能的影响
饲喂结束后(饲养试验第8周结束后),取罗非鱼脾脏和肾脏组织,利用南京建成生物公司生产的酶活测试盒测定鱼体组织中超氧化物歧化酶、髓过氧化物酶、丙二醛、过氧化氢酶及碱性磷酸酶的活性,比较分析饲料中添加姜黄组合物对鱼体免疫性能的影响。
3、数据处理
使用SPSS 20软件对所有试验数据进行单因素方差分析,试验数据均以“平均数±标准差”表示。
4、试验结果
(1)对罗非鱼血糖利用率的影响,结果参见表2。
表2对罗非鱼血糖(GLU(葡萄糖))利用率的影响
注:不同字母代表具有显著性差异,相同字母代表无显著性差异,各组件显著性水平为α=0.05,下表同。
试验结果:从表2中可以看出,各实施例试验组罗非鱼的血糖浓度均低于对照组和各对比例组,说明本发明方案对血糖的利用率高。
(2)对鱼体生长指标的影响,结果参见表3。
表3对鱼体生长指标的影响
试验结果:从表3中可以看出,各实施例试验组罗非鱼的末均重、增重率和特定生长率均高于对照组和对比例组,饲料系数低于对照组,说明添加本发明姜黄组合物可以提高罗非鱼的生长性能。
(3)对鱼体肝脏的影响,结果参见表4。
表4对鱼体肝脏的影响
指标 | 对照组 | 试验1组 | 试验2组 | 试验3组 |
AST(谷草转氨酶)U/L | 89.67±7.64<sup>c</sup> | 50.33±3.06<sup>a</sup> | 51.33±2.08<sup>a</sup> | 69.67±5.86<sup>b</sup> |
ALT(谷丙转氨酶)U/L | 36.33±0.58<sup>b</sup> | 26.33±2.08<sup>a</sup> | 24.33±2.08<sup>a</sup> | 33.67±2.52<sup>b</sup> |
指标 | 对比例1 | 对比例2 | 对比例3 | 对比例4 |
AST(谷草转氨酶)U/L | 91.67±3.06<sup>c</sup> | 70.33±5.03<sup>b</sup> | 70.67±4.04<sup>b</sup> | 71.62±3.13<sup>b</sup> |
ALT(谷丙转氨酶)U/L | 37.00±2.65<sup>b</sup> | 35.00±2.00<sup>b</sup> | 43.33±2.08<sup>c</sup> | 36.68±2.53<sup>b</sup> |
试验结果:从表4中可以看出,添加姜黄组合物的各实施例试验组对罗非鱼的肝脏具有一定的保护和调节作用,可提高鱼体机体的健康度。
(4)对鱼体抗氧化、免疫性能的影响,结果参见表5。
表5对鱼体抗氧化、免疫性能的影响
试验结果:从表5中可以看出,添加本发明姜黄组合物可以在一定程度上降低细胞的损伤,提高鱼体抗氧化和免疫能力。
以上结果表明,以本发明的组合物加入到罗非鱼的饲料喂养,可以有效提高罗非鱼对血糖的利用率,同时可以促进罗非鱼生长,抑制肝脏病变,提高鱼体抗氧化和免疫能力。
虽然,上文中已经用一般性说明及具体实施方案对本发明作了详尽的描述,但在本发明基础上,可以对之作一些修改或改进,这对本领域技术人员而言是显而易见的。因此,在不偏离本发明精神的基础上所做的这些修改或改进,均属于本发明要求保护的范围。
Claims (10)
1.一种姜黄组合物,包括姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素,其特征在于,所述姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素的质量比为(1-3):(4-6):(1-3)。
2.根据权利要求1所述的姜黄组合物,其特征在于,所述姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素的质量比为3:4:3。
3.根据权利要求1或2所述的姜黄组合物,其特征在于,还包括姜黄衍生物,所述姜黄衍生物为八氢姜黄素。
4.根据权利要求3所述的姜黄组合物,其特征在于,所述姜黄素、脱甲氧基姜黄素和双脱甲氧基姜黄素的总质量与所述姜黄衍生物的质量比为(1-3):3,优选为2:3。
5.根据权利要求1-4任一项所述的姜黄组合物,其特征在于,还包括木脂素类似物和载体,所述木脂素类似物为苯丙素低聚物;所述载体为稻壳粉、二氧化硅和石粉中一种或两种。
6.根据权利要求5所述的姜黄组合物,其特征在于,包括:姜黄素1-5份,脱甲氧基姜黄素2-8份,双脱甲氧基姜黄素2-6份,姜黄衍生物10-15份,木脂素类似物10-25份,载体30-60份。
7.根据权利要求6所述的姜黄组合物,其特征在于,包括:姜黄素3份,脱甲氧基姜黄素4份,双脱甲氧基姜黄素3份,姜黄衍生物15份,木脂素类似物25份,载体50份。
8.一种制备权利要求1-7任一项所述的姜黄组合物的方法,其特征在于,包括将各组分进行混合的步骤。
9.一种饲料,其特征在于,含有权利要求1-7任一项所述的姜黄组合物,优选,所述姜黄组合物在饲料中的添加量为300±50mg/kg。
10.一种权利要求1-7任一项所述的姜黄组合物,或权利要求8的方法制备得到的姜黄组合物,或权利要求9所述的饲料在提高罗非鱼血糖利用率、提高抗氧化和免疫能力、促进生长和/或保护肝脏中的应用。
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