CN114557930A - Essence with effects of relieving skin inflammation and repairing skin - Google Patents
Essence with effects of relieving skin inflammation and repairing skin Download PDFInfo
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Abstract
The application discloses an essence with effects of relieving skin inflammation and repairing, which comprises the following raw materials in parts by weight: 2-5 parts of ceramide compound, 2-5 parts of ergothioneine, 1-3 parts of kava root extract, 0.1-0.5 part of beta-glucan, 10-18 parts of humectant and 65-85 parts of deionized water. The essence with the effects of relieving skin inflammation and repairing has the effects of inhibiting bacteria, diminishing inflammation, relieving pain and itching and the like, effectively relieves inflammatory reaction, accelerates healing, and plays a role in relieving inflammation and repairing skin.
Description
Technical Field
The application relates to the technical field of skin repair essence, in particular to essence with effects of relieving skin inflammation and repairing skin inflammation.
Background
With the continuous fading of human physiological functions, under the influence of adverse factors such as pollution, pressure, ultraviolet rays and the like, skin damage often occurs, skin aging is accelerated, signs such as wrinkles, color spots, skin looseness and the like appear in advance, the skin damage is continuously worsened, even inflammation of different degrees occurs, and if the damaged skin is not repaired in time, more serious skin problems can be caused. In order to promote collagen hyperplasia, the collagen can help to repair skin matrix and promote self repair and renewal of the skin structure, and the rich antioxidant components can help the skin to resist environmental pressure. Therefore, repairing the skin by means of essence or the like to supplement nutrients required for the skin is a way to maintain the health of the skin. Most of the anti-inflammatory products on the market have the risk of drug dependence, and the actual anti-inflammatory and repairing efficacies are not obvious enough to meet the requirements of consumers.
Disclosure of Invention
The application aims to provide the essence with the effects of relieving skin inflammation and repairing, and has high anti-inflammatory and repairing effects.
In order to achieve the purpose, the application provides essence with skin inflammation relieving and repairing effects, and the essence comprises the following raw materials in parts by weight: 2-5 parts of ceramide compound, 2-5 parts of ergothioneine, 1-3 parts of kava root extract, 0.1-0.5 part of beta-glucan, 10-18 parts of humectant and 65-85 parts of deionized water.
Preferably, the essence with the effects of relieving skin inflammation and repairing skin inflammation further comprises 1-3 parts by weight of scutellaria baicalensis root extract and 1-3 parts by weight of paeonia lactiflora root extract.
Preferably, the preparation method of the scutellaria baicalensis root extract comprises the following steps:
step S1: cleaning fresh radix Scutellariae in clear water, peeling, cutting into blocks, and keeping fresh;
step S2: drying the root block of the scutellaria baicalensis in a vacuum drying box;
step S3: putting the dried root blocks of the scutellaria baicalensis into a powder stirrer for crushing to obtain scutellaria baicalensis root powder with the particle size of 220-500 mu m;
step S3: placing the radix scutellariae powder in a supercritical CO2 extraction kettle for extraction, setting the extraction environment to be 40-80 ℃, the pressure to be 2-10 MPa and the CO2 flow to be 10-30L/h, cooling to room temperature after extraction is finished, and extracting an upper layer of extraction liquid after aseptic standing for 3-5 h;
step S4: and (4) placing the upper-layer extract liquid obtained in the step (S3) in a supercritical CO2 extraction kettle for secondary extraction, setting the temperature to be 15-60 ℃, the pressure to be 6-20 MPa and the flow rate of CO2 to be 20-50L/h, cooling to room temperature after extraction is finished, and performing aseptic standing for 1-2h to extract the upper-layer extract liquid as a scutellaria baicalensis root extract.
Preferably, the preparation method of the peony root extract comprises the following steps:
step T1: cleaning fresh radix paeoniae alba, placing the cleaned fresh radix paeoniae alba in a vacuum drying oven for drying until surface moisture is evaporated, slicing the radix paeoniae alba subjected to surface moisture evaporation, and crushing the sliced radix paeoniae alba in a powder stirrer to obtain radix paeoniae alba powder with the particle size of 80-200 mu m;
step T2: adding 85-90% ethanol solution into the radix paeoniae alba powder, fully and uniformly stirring, performing ultrasonic extraction after uniform stirring, centrifuging the obtained extracting solution, and taking supernatant as radix paeoniae alba extracting solution;
step T3: removing ethanol from radix Paeoniae extract by reduced pressure distillation to obtain radix Paeoniae mixture;
step T4: adsorbing and resolving the radix paeoniae mixture obtained in the step T3 by resin to obtain a purified radix paeoniae extract.
Preferably, the kava root extract is an effective substance extracted from kava root, and specifically comprises kavalactone, kawain, and kavain.
Preferably, the humectant is a natural moisturizing factor polymer, and the natural moisturizing factor polymer comprises 3-6 parts by weight of amino acid, 2-5 parts by weight of pyrrolidone carboxylic acid, 0.6-1.8 parts by weight of sodium lactate, and 0.5-1.2 parts by weight of urea.
Preferably, the ceramide complex is a phospholipid complex with ceramide as a skeleton, and specifically includes ceramide phosphorylcholine, ceramide phosphorylethanolamine and ceramide.
Preferably, the ceramide is any one of ceramide I, ceramide compound II, ceramide compound III and ceramide compound VI; the preparation method of the ceramide compound comprises the following steps:
step P1: mixing ceramide phosphorylcholine, ceramide phosphorylethanolamine, ceramide and ethanol in a molar ratio of 1 (1.2-5) to (3-8) to (8-15), and then uniformly stirring to obtain a mixed solution;
step P2: and removing the ethanol in the mixed solution by adopting a reduced pressure distillation mode to obtain the ceramide compound.
Has the advantages that: the application discloses an essence with effects of relieving skin inflammation and repairing, a ceramide compound is a phospholipid class with a ceramide compound as a skeleton, the phospholipid class mainly comprises ceramide phosphorylcholine and ceramide phosphorylethanolamine, the phospholipid is a main component of a cell membrane, 40% -50% of sebum in a horny layer is formed by the ceramide compound, the ergothioneine has a protective effect and an anti-inflammatory effect on cells, the main effective components of kava are kavalactone, methysticine and kavain, the kavain can be used for bidirectionally regulating neurotransmitter, and the essence has multiple effects of resisting anxiety and depression, tranquilizing and hypnosis, local anesthesia, anticonvulsion and the like. Meanwhile, the essence with the effects of relieving skin inflammation and repairing has no drug dependence, has the effects of inhibiting bacteria, diminishing inflammation, relieving pain and itching and the like, effectively relieves inflammatory reaction, accelerates healing, and plays a role in relieving inflammation and repairing skin;
furthermore, the essence with the effects of relieving skin inflammation and repairing, the preparation method of the scutellaria baicalensis root extract, the paeonia lactiflora root extract and the ceramide compound is simple, the extraction quality and efficiency of effective substances in the scutellaria baicalensis root and the paeonia lactiflora root are high, the skin repairing and inflammation relieving performance of the essence can be fully improved, the ceramide dissolving amount in the prepared ceramide compound is high, and the prepared ceramide compound has good transdermal absorption capacity, so that the skin repairing and inflammation relieving performance of the essence is ensured.
Detailed Description
The technical solutions in the embodiments of the present invention will be clearly and completely described below, and it is obvious that the described embodiments are only a part of the embodiments of the present invention, and not all embodiments. All other embodiments, which can be derived by a person skilled in the art from the embodiments given herein without making any creative effort, shall fall within the protection scope of the present invention.
Example 1
The essence with the effects of relieving skin inflammation and repairing skin inflammation comprises the following raw materials in parts by weight: 2 parts by weight of ceramide compound, 2 parts by weight of ergothioneine, 1 part by weight of kava root extract, 0.1 part by weight of beta-glucan, 10 parts by weight of humectant and 65 parts by weight of deionized water. The kava root extract is effective components extracted from kava root, and specifically comprises kavalactone, kavalorine, and kavain. The humectant is a natural moisturizing factor polymer, and the natural moisturizing factor polymer comprises 3-6 parts by weight of amino acid, 2-5 parts by weight of pyrrolidone carboxylic acid, 0.6-1.8 parts by weight of sodium lactate, and 0.5-1.2 parts by weight of urea.
The ceramide compound is a phospholipid compound taking ceramide as a framework, and specifically comprises ceramide phosphorylcholine, ceramide phosphorylethanolamine and ceramide. The ceramide is any one of ceramide I, ceramide compound II, ceramide compound III and ceramide compound VI. The preparation method of the ceramide compound comprises the following steps:
step P1: mixing ceramide phosphorylcholine, ceramide phosphorylethanolamine, ceramide and ethanol in a molar ratio of 1:1.2:3:8, and then uniformly stirring to obtain a mixed solution;
step P2: and removing the ethanol in the mixed solution by adopting a reduced pressure distillation mode to obtain the ceramide compound.
The essence with the effects of relieving skin inflammation and repairing skin inflammation in the embodiment comprises the following preparation steps:
(1) accurately weighing 1 part by weight of kava root extract, 0.1 part by weight of beta-glucan, 10 parts by weight of humectant and 65 parts by weight of deionized water, fully mixing and uniformly stirring to prepare an A1 phase;
(2) accurately weighing 2 parts by weight of ergothioneine and 2 parts by weight of ceramide compound, and uniformly dispersing to obtain a B1 phase;
(3) and adding the phase B1 into the phase A1, uniformly stirring the mixture in a stirring kettle at the temperature of 30-45 ℃ and the rotating speed of 900-1200 r/min, and cooling the mixture to room temperature after stirring to obtain the essence with the effects of relieving the dermatitis and repairing the dermatitis.
Example 2
The essence with the effects of relieving skin inflammation and repairing skin inflammation comprises the following raw materials in parts by weight: 2 parts by weight of ceramide complex, 2 parts by weight of ergothioneine, 1 part by weight of kava root extract, 0.1 part by weight of beta-glucan, 10 parts by weight of humectant, 65 parts by weight of deionized water, 1 part by weight of scutellaria root extract and 1 part by weight of paeonia lactiflora root extract. The kava root extract is effective components extracted from kava root, and specifically comprises kavalactone, kavalorine, and kavain. The humectant is a natural moisturizing factor polymer, and the natural moisturizing factor polymer comprises 3-6 parts by weight of amino acid, 2-5 parts by weight of pyrrolidone carboxylic acid, 0.6-1.8 parts by weight of sodium lactate, and 0.5-1.2 parts by weight of urea.
The preparation method of the scutellaria baicalensis root extract comprises the following steps of:
step S1: cleaning fresh radix Scutellariae in clear water, peeling, cutting into pieces, and keeping fresh;
step S2: drying the root block of the scutellaria baicalensis in a vacuum drying box;
step S3: putting the dried root blocks of the scutellaria baicalensis into a powder stirrer for crushing to obtain scutellaria baicalensis root powder with the particle size of 220-500 mu m;
step S3: placing the radix scutellariae powder in a supercritical CO2 extraction kettle for extraction, setting the extraction environment to be 40-80 ℃, the pressure to be 2-10 MPa and the CO2 flow to be 10-30L/h, cooling to room temperature after extraction is finished, and extracting an upper layer of extraction liquid after aseptic standing for 3-5 h;
step S4: and (4) placing the upper layer extract obtained in the step (S3) in a supercritical CO2 extraction kettle for secondary extraction, setting the temperature to be 15-60 ℃, the pressure to be 6-20 MPa and the CO2 flow rate to be 20-50L/h, cooling to room temperature after extraction is finished, and performing aseptic standing for 1-2h to extract the upper layer extract to serve as the scutellaria baicalensis root extract.
The preparation method of the peony root extract comprises the following steps:
step T1: cleaning fresh radix paeoniae alba, placing the cleaned fresh radix paeoniae alba in a vacuum drying oven for drying until surface moisture is evaporated, slicing the radix paeoniae alba subjected to surface moisture evaporation, and crushing the sliced radix paeoniae alba in a powder stirrer to obtain radix paeoniae alba powder with the particle size of 80-200 mu m;
step T2: adding 85-90% ethanol solution into the radix paeoniae alba powder, fully and uniformly stirring, performing ultrasonic extraction after uniform stirring, centrifuging the obtained extracting solution, and taking supernatant as radix paeoniae alba extracting solution;
step T3: removing ethanol from radix Paeoniae extract by vacuum distillation to obtain radix Paeoniae mixture;
step T4: adsorbing and resolving the radix paeoniae mixture obtained in the step T3 by resin to obtain a purified radix paeoniae extract.
The ceramide compound is a phospholipid compound taking ceramide as a framework, and specifically comprises ceramide phosphorylcholine, ceramide phosphorylethanolamine and ceramide. The ceramide is any one of ceramide I, ceramide compound II, ceramide compound III and ceramide compound VI; the preparation method of the ceramide compound comprises the following steps:
step P1: mixing ceramide phosphorylcholine, ceramide phosphorylethanolamine, ceramide and ethanol in a molar ratio of 1:1.2:3:8, and then uniformly stirring to obtain a mixed solution;
step P2: and removing the ethanol in the mixed solution by adopting a reduced pressure distillation mode to obtain the ceramide compound.
The essence with the effects of relieving skin inflammation and repairing skin inflammation in the embodiment comprises the following preparation steps:
(1) accurately weighing 1 weight part of radix Scutellariae extract, 1 weight part of radix Paeoniae extract, 0.1 weight part of beta-glucan, 10 weight parts of humectant and 65 weight parts of deionized water, and mixing and stirring to obtain phase A2;
(2) accurately weighing 1 weight part of kava root extract, 2 weight parts of ergothioneine and 2 weight parts of ceramide compound, and uniformly dispersing to obtain a B2 phase;
(3) and adding the phase B2 into the phase A2, uniformly stirring the mixture in a stirring kettle at the temperature of 30-45 ℃ and the rotating speed of 900-1200 r/min, and cooling the mixture to room temperature after stirring to obtain the essence with the effects of relieving the dermatitis and repairing the dermatitis.
Example 3
The essence with the effects of relieving skin inflammation and repairing skin inflammation comprises the following raw materials in parts by weight: 3.5 parts by weight of ceramide complex, 3.5 parts by weight of ergothioneine, 2 parts by weight of kava root extract, 0.35 parts by weight of beta-glucan, 14 parts by weight of humectant, 72.5 parts by weight of deionized water, 2 parts by weight of scutellaria root extract and 2 parts by weight of paeonia lactiflora root extract. The kava root extract is effective components extracted from kava root, and specifically comprises kavalactone, kawain, and kavain. The humectant is a natural moisturizing factor polymer, and the natural moisturizing factor polymer comprises 3-6 parts by weight of amino acid, 2-5 parts by weight of pyrrolidone carboxylic acid, 0.6-1.8 parts by weight of sodium lactate, and 0.5-1.2 parts by weight of urea.
The preparation method of the scutellaria baicalensis root extract comprises the following steps of:
step S1: cleaning fresh radix Scutellariae in clear water, peeling, cutting into blocks, and keeping fresh;
step S2: drying the root block of the scutellaria baicalensis in a vacuum drying box;
step S3: putting the dried root blocks of the scutellaria baicalensis into a powder stirrer for crushing to obtain scutellaria baicalensis root powder with the particle size of 220-500 mu m;
step S3: placing the radix scutellariae powder in a supercritical CO2 extraction kettle for extraction, setting the extraction environment to be 40-80 ℃, the pressure to be 2-10 MPa and the flow rate of CO2 to be 10-30L/h, cooling to room temperature after extraction is finished, and extracting an upper layer of extraction liquid after aseptic standing for 3-5 h;
step S4: and (4) placing the upper layer extract obtained in the step (S3) in a supercritical CO2 extraction kettle for secondary extraction, setting the temperature to be 15-60 ℃, the pressure to be 6-20 MPa and the CO2 flow rate to be 20-50L/h, cooling to room temperature after extraction is finished, and performing aseptic standing for 1-2h to extract the upper layer extract to serve as the scutellaria baicalensis root extract.
The preparation method of the peony root extract comprises the following steps:
step T1: cleaning fresh radix paeoniae alba, placing the cleaned fresh radix paeoniae alba in a vacuum drying oven for drying until surface moisture is evaporated, slicing the radix paeoniae alba subjected to surface moisture evaporation, and crushing the sliced radix paeoniae alba in a powder stirrer to obtain radix paeoniae alba powder with the particle size of 80-200 mu m;
step T2: adding 85-90% ethanol solution into the radix paeoniae alba powder, fully and uniformly stirring, performing ultrasonic extraction after uniform stirring, centrifuging the obtained extracting solution, and taking supernatant as radix paeoniae alba extracting solution;
step T3: removing ethanol from radix Paeoniae extract by reduced pressure distillation to obtain radix Paeoniae mixture;
step T4: adsorbing and resolving the radix paeoniae mixture obtained in the step T3 by resin to obtain a purified radix paeoniae extract.
The ceramide compound is a phospholipid compound taking ceramide as a skeleton, and specifically comprises ceramide phosphorylcholine, ceramide phosphorylethanolamine and ceramide. The ceramide is any one of ceramide I, ceramide compound II, ceramide compound III and ceramide compound VI; the preparation method of the ceramide compound comprises the following steps:
step P1: mixing ceramide phosphorylcholine, ceramide phosphorylethanolamine, ceramide and ethanol in a molar ratio of 1:1.2:3:8, and then uniformly stirring to obtain a mixed solution;
step P2: and removing the ethanol in the mixed solution by adopting a reduced pressure distillation mode to obtain the ceramide compound.
The essence with the effects of relieving skin inflammation and repairing skin inflammation in the embodiment comprises the following preparation steps:
(1) accurately weighing 2 parts by weight of radix scutellariae extract, 2 parts by weight of radix paeoniae alba extract, 0.35 part by weight of beta-glucan, 14 parts by weight of humectant and 72.5 parts by weight of deionized water, fully mixing and uniformly stirring to obtain phase A3;
(2) accurately weighing 1 part by weight of 3.5 parts by weight of ceramide compound, 3.5 parts by weight of ergothioneine and 2 parts by weight of kava root extract, and uniformly dispersing to obtain a phase B3;
(3) and adding the phase B3 into the phase A3, uniformly stirring the mixture in a stirring kettle at the temperature of 30-45 ℃ and the rotating speed of 900-1200 r/min, and cooling the mixture to room temperature after stirring to obtain the essence with the effects of relieving the dermatitis and repairing the dermatitis.
Example 4
The essence with the effects of relieving skin inflammation and repairing comprises the following raw materials in parts by weight: 5 parts by weight of ceramide complex, 5 parts by weight of ergothioneine, 3 parts by weight of kava root extract, 0.5 part by weight of beta-glucan, 18 parts by weight of humectant, 85 parts by weight of deionized water, 3 parts by weight of scutellaria root extract and 3 parts by weight of paeonia lactiflora root extract. The kava root extract is effective components extracted from kava root, and specifically comprises kavalactone, kavalorine, and kavain. The humectant is a natural moisturizing factor polymer, and the natural moisturizing factor polymer comprises 3-6 parts by weight of amino acid, 2-5 parts by weight of pyrrolidone carboxylic acid, 0.6-1.8 parts by weight of sodium lactate, and 0.5-1.2 parts by weight of urea.
The preparation method of the scutellaria baicalensis root extract comprises the following steps of:
step S1: cleaning fresh radix Scutellariae in clear water, peeling, cutting into blocks, and keeping fresh;
step S2: drying the root block of the scutellaria baicalensis in a vacuum drying box;
step S3: putting the dried root blocks of the scutellaria baicalensis into a powder stirrer for crushing to obtain scutellaria baicalensis root powder with the particle size of 220-500 mu m;
step S3: placing the radix scutellariae powder in a supercritical CO2 extraction kettle for extraction, setting the extraction environment to be 40-80 ℃, the pressure to be 2-10 MPa and the CO2 flow to be 10-30L/h, cooling to room temperature after extraction is finished, and extracting an upper layer of extraction liquid after aseptic standing for 3-5 h;
step S4: and (4) placing the upper-layer extract liquid obtained in the step (S3) in a supercritical CO2 extraction kettle for secondary extraction, setting the temperature to be 15-60 ℃, the pressure to be 6-20 MPa and the flow rate of CO2 to be 20-50L/h, cooling to room temperature after extraction is finished, and performing aseptic standing for 1-2h to extract the upper-layer extract liquid as a scutellaria baicalensis root extract.
The preparation method of the peony root extract comprises the following steps:
step T1: cleaning fresh radix paeoniae alba, placing the cleaned fresh radix paeoniae alba in a vacuum drying oven for drying until surface water is evaporated, slicing the radix paeoniae alba subjected to surface water evaporation, and crushing the sliced radix paeoniae alba in a powder stirrer to obtain radix paeoniae alba powder with the particle size of 80-200 microns;
step T2: adding 85-90% ethanol solution into the radix paeoniae alba powder, fully and uniformly stirring, performing ultrasonic extraction after uniform stirring, centrifuging the obtained extracting solution, and taking supernatant as radix paeoniae alba extracting solution;
step T3: removing ethanol from radix Paeoniae extract by reduced pressure distillation to obtain radix Paeoniae mixture;
step T4: adsorbing and resolving the radix paeoniae mixture obtained in the step T3 by resin to obtain a purified radix paeoniae extract.
The ceramide compound is a phospholipid compound taking ceramide as a skeleton, and specifically comprises ceramide phosphorylcholine, ceramide phosphorylethanolamine and ceramide. The ceramide is any one of ceramide I, ceramide compound II, ceramide compound III and ceramide compound VI; the preparation method of the ceramide compound comprises the following steps:
step P1: mixing ceramide phosphorylcholine, ceramide phosphorylethanolamine, ceramide and ethanol in a molar ratio of 1 (1.2-5) to (3-8) to (8-15), and then uniformly stirring to obtain a mixed solution;
step P2: and removing the ethanol in the mixed solution by adopting a reduced pressure distillation mode to obtain the ceramide compound.
The essence with the effects of relieving skin inflammation and repairing skin inflammation in the embodiment comprises the following preparation steps:
(1) accurately weighing 3 parts by weight of radix scutellariae extract, 3 parts by weight of radix paeoniae alba extract, 0.5 part by weight of beta-glucan, 18 parts by weight of humectant and 85 parts by weight of deionized water, fully mixing and uniformly stirring to prepare A4 phase;
(2) accurately weighing 5 parts by weight of ceramide compound, 5 parts by weight of ergothioneine and 3 parts by weight of kava root extract, and uniformly dispersing to obtain a B4 phase;
(3) and adding the phase B4 into the phase A4, uniformly stirring the mixture in a stirring kettle at the temperature of 30-45 ℃ and the rotating speed of 900-1200 r/min, and cooling the mixture to room temperature after stirring to obtain the essence with the effects of relieving the dermatitis and repairing the dermatitis.
Examples of the experiments
80 male volunteers and 80 female volunteers with the age range of 25-40 years are selected as experimental objects, wherein the skins of the 80 male volunteers and the 80 female volunteers have inflammatory manifestations with different degrees.
Example 1, example 2, example 3, example 4, example 5, example 6, comparative example 1, comparative example 2 were given to 5 male volunteers and 5 female volunteers, respectively, for application.
Every seven days is set as a test period and is continuously used for one month. The volunteers of each group were examined for signs of skin inflammation at the end of each test period and the average score of all volunteers in each group was calculated. When the score is given, 0 score represents no inflammation of the skin, 1 score represents mild inflammation, 2 score represents moderate inflammation, and 3 score represents severe inflammation, and the examination results shown in table 1 are obtained after statistics.
The period 0 indicates the detection time corresponding to the score when the experiment is not started.
TABLE 1
As can be seen from table 1, the essence for relieving skin inflammation and repairing, which is composed of ceramide complex, ergothioneine, kava root extract, beta-glucan, humectant, deionized water, scutellaria root extract and paeonia radix extract, has the functions of diminishing inflammation and repairing skin, and the addition of scutellaria root extract and paeonia radix extract has the effects of promoting skin inflammation and repairing skin.
Finally, it should be noted that: although the present invention has been described in detail with reference to the foregoing embodiments, it will be apparent to those skilled in the art that modifications may be made to the embodiments or portions thereof without departing from the spirit and scope of the invention.
Claims (8)
1. The essence with the effects of relieving skin inflammation and repairing is characterized by comprising the following raw materials in parts by weight: 2-5 parts of ceramide compound, 2-5 parts of ergothioneine, 1-3 parts of kava root extract, 0.1-0.5 part of beta-glucan, 10-18 parts of humectant and 65-85 parts of deionized water.
2. The essence with skin inflammation relieving and repairing effects as claimed in claim 1, wherein the essence with skin inflammation relieving and repairing effects further comprises 1-3 parts by weight of scutellaria baicalensis root extract and 1-3 parts by weight of paeonia lactiflora root extract.
3. The essence with skin inflammation relieving and skin repair effects according to claim 2, wherein the preparation method of the scutellaria baicalensis root extract comprises the following steps:
step S1: cleaning fresh radix Scutellariae in clear water, peeling, cutting into blocks, and keeping fresh;
step S2: drying the root block of the scutellaria baicalensis in a vacuum drying box;
step S3: putting the dried root blocks of the scutellaria baicalensis into a powder stirrer for crushing to obtain scutellaria baicalensis root powder with the particle size of 220-500 mu m;
step S3: placing the radix scutellariae powder in a supercritical CO2 extraction kettle for extraction, setting the extraction environment to be 40-80 ℃, the pressure to be 2-10 MPa and the CO2 flow to be 10-30L/h, cooling to room temperature after extraction is finished, and extracting an upper layer of extraction liquid after aseptic standing for 3-5 h;
step S4: and (4) placing the upper layer extract obtained in the step (S3) in a supercritical CO2 extraction kettle for secondary extraction, setting the temperature to be 15-60 ℃, the pressure to be 6-20 MPa and the CO2 flow rate to be 20-50L/h, cooling to room temperature after extraction is finished, and performing aseptic standing for 1-2h to extract the upper layer extract to serve as the scutellaria baicalensis root extract.
4. The essence with skin inflammation relieving and repairing effects as claimed in claim 2, wherein the preparation method of the peony root extract comprises the following steps:
step T1: cleaning fresh radix paeoniae alba, placing the cleaned fresh radix paeoniae alba in a vacuum drying oven for drying until surface moisture is evaporated, slicing the radix paeoniae alba subjected to surface moisture evaporation, and crushing the sliced radix paeoniae alba in a powder stirrer to obtain radix paeoniae alba powder with the particle size of 80-200 mu m;
step T2: adding an ethanol solution with volume concentration of 85-90% into the paeony root powder, fully and uniformly stirring, carrying out ultrasonic extraction after uniform stirring, centrifuging the obtained extracting solution, and taking supernatant as a paeony root extracting solution;
step T3: removing ethanol from radix Paeoniae extract by reduced pressure distillation to obtain radix Paeoniae mixture;
step T4: adsorbing and resolving the radix paeoniae mixture obtained in the step T3 by resin to obtain a purified radix paeoniae extract.
5. The essence with skin inflammation relieving and skin repair effects according to claim 1, wherein the kava root extract is an effective substance extracted from kava root, and specifically comprises kavalactone, kawaine, and kavain.
6. The essence with effects of relieving skin inflammation and repairing skin according to claim 1, wherein the moisturizer is a natural moisturizing factor polymer, and the natural moisturizing factor polymer comprises 3-6 parts by weight of amino acid, 2-5 parts by weight of pyrrolidone carboxylic acid, 0.6-1.8 parts by weight of sodium lactate, and 0.5-1.2 parts by weight of urea.
7. The essence with skin inflammation relieving and skin repair effects according to claim 1, wherein the ceramide complex is a phospholipid complex with a ceramide as a skeleton, and specifically comprises ceramide phosphorylcholine, ceramide phosphorylethanolamine and ceramide.
8. The essence with skin inflammation relieving and skin repair effects according to claim 6, wherein the ceramide is any one of ceramide I, ceramide complex II, ceramide complex III and ceramide complex VI; the preparation method of the ceramide compound comprises the following steps:
step P1: mixing ceramide phosphorylcholine, ceramide phosphorylethanolamine, ceramide and ethanol in a molar ratio of 1 (1.2-5) to (3-8) to (8-15), and then uniformly stirring to obtain a mixed solution;
step P2: and removing the ethanol in the mixed solution by adopting a reduced pressure distillation mode to obtain the ceramide compound.
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Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177570A (en) * | 2022-08-17 | 2022-10-14 | 科乐美(广州)生物科技有限公司 | Composition with soothing and repairing effects and preparation method and application thereof |
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Cited By (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN115177570A (en) * | 2022-08-17 | 2022-10-14 | 科乐美(广州)生物科技有限公司 | Composition with soothing and repairing effects and preparation method and application thereof |
| CN115177570B (en) * | 2022-08-17 | 2023-09-12 | 科乐美(广州)生物科技有限公司 | Composition with relieving and repairing effects and preparation method and application thereof |
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