CN114521655A - Intestinal tract probiotic promoter containing medium-long chain triglyceride in almond oil and preparation method and application thereof - Google Patents
Intestinal tract probiotic promoter containing medium-long chain triglyceride in almond oil and preparation method and application thereof Download PDFInfo
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- CN114521655A CN114521655A CN202210102861.5A CN202210102861A CN114521655A CN 114521655 A CN114521655 A CN 114521655A CN 202210102861 A CN202210102861 A CN 202210102861A CN 114521655 A CN114521655 A CN 114521655A
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- almond oil
- chain triglyceride
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- intestinal
- probiotic
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- 235000019489 Almond oil Nutrition 0.000 title claims abstract description 91
- 239000008168 almond oil Substances 0.000 title claims abstract description 91
- UFTFJSFQGQCHQW-UHFFFAOYSA-N triformin Chemical compound O=COCC(OC=O)COC=O UFTFJSFQGQCHQW-UHFFFAOYSA-N 0.000 title claims abstract description 63
- 239000006041 probiotic Substances 0.000 title claims abstract description 47
- 235000018291 probiotics Nutrition 0.000 title claims abstract description 47
- 230000000529 probiotic effect Effects 0.000 title claims abstract description 33
- 210000001035 gastrointestinal tract Anatomy 0.000 title claims abstract description 25
- 238000002360 preparation method Methods 0.000 title claims abstract description 17
- 230000000968 intestinal effect Effects 0.000 claims abstract description 31
- 150000004665 fatty acids Chemical class 0.000 claims abstract description 18
- 239000000194 fatty acid Substances 0.000 claims abstract description 17
- 108090001060 Lipase Proteins 0.000 claims abstract description 16
- 239000004367 Lipase Substances 0.000 claims abstract description 16
- 102000004882 Lipase Human genes 0.000 claims abstract description 16
- 235000014113 dietary fatty acids Nutrition 0.000 claims abstract description 16
- 229930195729 fatty acid Natural products 0.000 claims abstract description 16
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- 238000000034 method Methods 0.000 claims abstract description 13
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- 239000003995 emulsifying agent Substances 0.000 claims abstract description 9
- 230000035755 proliferation Effects 0.000 claims abstract description 9
- 238000002156 mixing Methods 0.000 claims abstract description 8
- 230000001105 regulatory effect Effects 0.000 claims abstract description 7
- 241000186000 Bifidobacterium Species 0.000 claims abstract description 5
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- 229940039696 lactobacillus Drugs 0.000 claims abstract description 5
- CDBYLPFSWZWCQE-UHFFFAOYSA-L Sodium Carbonate Chemical compound [Na+].[Na+].[O-]C([O-])=O CDBYLPFSWZWCQE-UHFFFAOYSA-L 0.000 claims description 14
- 239000007864 aqueous solution Substances 0.000 claims description 13
- 108010048733 Lipozyme Proteins 0.000 claims description 10
- 238000001035 drying Methods 0.000 claims description 10
- POULHZVOKOAJMA-UHFFFAOYSA-N dodecanoic acid Chemical compound CCCCCCCCCCCC(O)=O POULHZVOKOAJMA-UHFFFAOYSA-N 0.000 claims description 9
- 239000000706 filtrate Substances 0.000 claims description 9
- GHVNFZFCNZKVNT-UHFFFAOYSA-N decanoic acid Chemical compound CCCCCCCCCC(O)=O GHVNFZFCNZKVNT-UHFFFAOYSA-N 0.000 claims description 8
- IPCSVZSSVZVIGE-UHFFFAOYSA-N hexadecanoic acid Chemical compound CCCCCCCCCCCCCCCC(O)=O IPCSVZSSVZVIGE-UHFFFAOYSA-N 0.000 claims description 8
- WWZKQHOCKIZLMA-UHFFFAOYSA-N octanoic acid Chemical compound CCCCCCCC(O)=O WWZKQHOCKIZLMA-UHFFFAOYSA-N 0.000 claims description 8
- 239000000047 product Substances 0.000 claims description 7
- 229910000029 sodium carbonate Inorganic materials 0.000 claims description 7
- 150000001875 compounds Chemical class 0.000 claims description 6
- FCCDDURTIIUXBY-UHFFFAOYSA-N lipoamide Chemical compound NC(=O)CCCCC1CCSS1 FCCDDURTIIUXBY-UHFFFAOYSA-N 0.000 claims description 6
- 239000007788 liquid Substances 0.000 claims description 5
- 230000001737 promoting effect Effects 0.000 claims description 5
- TWJNQYPJQDRXPH-UHFFFAOYSA-N 2-cyanobenzohydrazide Chemical compound NNC(=O)C1=CC=CC=C1C#N TWJNQYPJQDRXPH-UHFFFAOYSA-N 0.000 claims description 4
- 239000005632 Capric acid (CAS 334-48-5) Substances 0.000 claims description 4
- 239000005635 Caprylic acid (CAS 124-07-2) Substances 0.000 claims description 4
- 239000005639 Lauric acid Substances 0.000 claims description 4
- 235000021360 Myristic acid Nutrition 0.000 claims description 4
- TUNFSRHWOTWDNC-UHFFFAOYSA-N Myristic acid Natural products CCCCCCCCCCCCCC(O)=O TUNFSRHWOTWDNC-UHFFFAOYSA-N 0.000 claims description 4
- 235000021314 Palmitic acid Nutrition 0.000 claims description 4
- HVUMOYIDDBPOLL-XWVZOOPGSA-N Sorbitan monostearate Chemical compound CCCCCCCCCCCCCCCCCC(=O)OC[C@@H](O)[C@H]1OC[C@H](O)[C@H]1O HVUMOYIDDBPOLL-XWVZOOPGSA-N 0.000 claims description 4
- WQEPLUUGTLDZJY-UHFFFAOYSA-N n-Pentadecanoic acid Natural products CCCCCCCCCCCCCCC(O)=O WQEPLUUGTLDZJY-UHFFFAOYSA-N 0.000 claims description 4
- 229960002446 octanoic acid Drugs 0.000 claims description 4
- 239000007787 solid Substances 0.000 claims description 4
- LDVVTQMJQSCDMK-UHFFFAOYSA-N 1,3-dihydroxypropan-2-yl formate Chemical compound OCC(CO)OC=O LDVVTQMJQSCDMK-UHFFFAOYSA-N 0.000 claims description 3
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 3
- 229920000053 polysorbate 80 Polymers 0.000 claims description 3
- 239000004480 active ingredient Substances 0.000 claims description 2
- 239000003795 chemical substances by application Substances 0.000 claims description 2
- 230000035484 reaction time Effects 0.000 claims description 2
- 239000006228 supernatant Substances 0.000 claims description 2
- 238000001291 vacuum drying Methods 0.000 claims description 2
- 239000003921 oil Substances 0.000 abstract description 2
- 235000019198 oils Nutrition 0.000 abstract description 2
- 239000012295 chemical reaction liquid Substances 0.000 description 8
- 241000700159 Rattus Species 0.000 description 7
- 150000003626 triacylglycerols Chemical class 0.000 description 7
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 5
- 230000000694 effects Effects 0.000 description 5
- 238000001914 filtration Methods 0.000 description 5
- 238000005406 washing Methods 0.000 description 5
- 244000144725 Amygdalus communis Species 0.000 description 4
- 241000894006 Bacteria Species 0.000 description 4
- 235000020224 almond Nutrition 0.000 description 4
- 230000009286 beneficial effect Effects 0.000 description 4
- 235000013305 food Nutrition 0.000 description 4
- ONRGCKHNIPGJGT-BFIYWSAOSA-N (9z,12z)-octadeca-9,12-dienoic acid;(z)-octadec-9-enoic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O.CCCCC\C=C/C\C=C/CCCCCCCC(O)=O ONRGCKHNIPGJGT-BFIYWSAOSA-N 0.000 description 3
- 235000011437 Amygdalus communis Nutrition 0.000 description 3
- 230000000052 comparative effect Effects 0.000 description 3
- 150000004668 long chain fatty acids Chemical class 0.000 description 3
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- 239000000203 mixture Substances 0.000 description 3
- WRIDQFICGBMAFQ-UHFFFAOYSA-N (E)-8-Octadecenoic acid Natural products CCCCCCCCCC=CCCCCCCC(O)=O WRIDQFICGBMAFQ-UHFFFAOYSA-N 0.000 description 2
- GFAZGHREJPXDMH-UHFFFAOYSA-N 1,3-dipalmitoylglycerol Chemical compound CCCCCCCCCCCCCCCC(=O)OCC(O)COC(=O)CCCCCCCCCCCCCCC GFAZGHREJPXDMH-UHFFFAOYSA-N 0.000 description 2
- LQJBNNIYVWPHFW-UHFFFAOYSA-N 20:1omega9c fatty acid Natural products CCCCCCCCCCC=CCCCCCCCC(O)=O LQJBNNIYVWPHFW-UHFFFAOYSA-N 0.000 description 2
- QSBYPNXLFMSGKH-UHFFFAOYSA-N 9-Heptadecensaeure Natural products CCCCCCCC=CCCCCCCCC(O)=O QSBYPNXLFMSGKH-UHFFFAOYSA-N 0.000 description 2
- 239000005642 Oleic acid Substances 0.000 description 2
- ZQPPMHVWECSIRJ-UHFFFAOYSA-N Oleic acid Natural products CCCCCCCCC=CCCCCCCCC(O)=O ZQPPMHVWECSIRJ-UHFFFAOYSA-N 0.000 description 2
- 230000009471 action Effects 0.000 description 2
- HVYWMOMLDIMFJA-DPAQBDIFSA-N cholesterol Chemical compound C1C=C2C[C@@H](O)CC[C@]2(C)[C@@H]2[C@@H]1[C@@H]1CC[C@H]([C@H](C)CCCC(C)C)[C@@]1(C)CC2 HVYWMOMLDIMFJA-DPAQBDIFSA-N 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 235000005911 diet Nutrition 0.000 description 2
- 230000037213 diet Effects 0.000 description 2
- 210000003608 fece Anatomy 0.000 description 2
- 235000011187 glycerol Nutrition 0.000 description 2
- -1 glyceryl monocaprylate (linoleic acid) Chemical compound 0.000 description 2
- 230000036541 health Effects 0.000 description 2
- 235000009200 high fat diet Nutrition 0.000 description 2
- QXJSBBXBKPUZAA-UHFFFAOYSA-N isooleic acid Natural products CCCCCCCC=CCCCCCCCCC(O)=O QXJSBBXBKPUZAA-UHFFFAOYSA-N 0.000 description 2
- 150000004667 medium chain fatty acids Chemical class 0.000 description 2
- 244000005700 microbiome Species 0.000 description 2
- 230000004048 modification Effects 0.000 description 2
- 238000012986 modification Methods 0.000 description 2
- ZQPPMHVWECSIRJ-KTKRTIGZSA-N oleic acid Chemical compound CCCCCCCC\C=C/CCCCCCCC(O)=O ZQPPMHVWECSIRJ-KTKRTIGZSA-N 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 239000000243 solution Substances 0.000 description 2
- OQQOAWVKVDAJOI-UHFFFAOYSA-N (2-dodecanoyloxy-3-hydroxypropyl) dodecanoate Chemical compound CCCCCCCCCCCC(=O)OCC(CO)OC(=O)CCCCCCCCCCC OQQOAWVKVDAJOI-UHFFFAOYSA-N 0.000 description 1
- OYHQOLUKZRVURQ-NTGFUMLPSA-N (9Z,12Z)-9,10,12,13-tetratritiooctadeca-9,12-dienoic acid Chemical compound C(CCCCCCC\C(=C(/C\C(=C(/CCCCC)\[3H])\[3H])\[3H])\[3H])(=O)O OYHQOLUKZRVURQ-NTGFUMLPSA-N 0.000 description 1
- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 description 1
- OYHQOLUKZRVURQ-HZJYTTRNSA-N Linoleic acid Chemical compound CCCCC\C=C/C\C=C/CCCCCCCC(O)=O OYHQOLUKZRVURQ-HZJYTTRNSA-N 0.000 description 1
- 235000019483 Peanut oil Nutrition 0.000 description 1
- BAECOWNUKCLBPZ-HIUWNOOHSA-N Triolein Natural products O([C@H](OCC(=O)CCCCCCC/C=C\CCCCCCCC)COC(=O)CCCCCCC/C=C\CCCCCCCC)C(=O)CCCCCCC/C=C\CCCCCCCC BAECOWNUKCLBPZ-HIUWNOOHSA-N 0.000 description 1
- PHYFQTYBJUILEZ-UHFFFAOYSA-N Trioleoylglycerol Natural products CCCCCCCCC=CCCCCCCCC(=O)OCC(OC(=O)CCCCCCCC=CCCCCCCCC)COC(=O)CCCCCCCC=CCCCCCCCC PHYFQTYBJUILEZ-UHFFFAOYSA-N 0.000 description 1
- 244000052616 bacterial pathogen Species 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 230000037396 body weight Effects 0.000 description 1
- 235000012000 cholesterol Nutrition 0.000 description 1
- 230000029087 digestion Effects 0.000 description 1
- 201000010099 disease Diseases 0.000 description 1
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 238000009472 formulation Methods 0.000 description 1
- 239000008103 glucose Substances 0.000 description 1
- 229940074049 glyceryl dilaurate Drugs 0.000 description 1
- 125000003976 glyceryl group Chemical group [H]C([*])([H])C(O[H])([H])C(O[H])([H])[H] 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- 230000036039 immunity Effects 0.000 description 1
- 230000006872 improvement Effects 0.000 description 1
- 238000001727 in vivo Methods 0.000 description 1
- 238000009776 industrial production Methods 0.000 description 1
- 208000028774 intestinal disease Diseases 0.000 description 1
- 210000000936 intestine Anatomy 0.000 description 1
- 150000002576 ketones Chemical class 0.000 description 1
- 235000020778 linoleic acid Nutrition 0.000 description 1
- OYHQOLUKZRVURQ-IXWMQOLASA-N linoleic acid Natural products CCCCC\C=C/C\C=C\CCCCCCCC(O)=O OYHQOLUKZRVURQ-IXWMQOLASA-N 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 235000015097 nutrients Nutrition 0.000 description 1
- 235000016709 nutrition Nutrition 0.000 description 1
- 230000035764 nutrition Effects 0.000 description 1
- 230000001717 pathogenic effect Effects 0.000 description 1
- 239000000312 peanut oil Substances 0.000 description 1
- 230000008855 peristalsis Effects 0.000 description 1
- 230000035790 physiological processes and functions Effects 0.000 description 1
- 231100000614 poison Toxicity 0.000 description 1
- 229920000136 polysorbate Polymers 0.000 description 1
- 230000002040 relaxant effect Effects 0.000 description 1
- 238000012163 sequencing technique Methods 0.000 description 1
- NRHMKIHPTBHXPF-TUJRSCDTSA-M sodium cholate Chemical compound [Na+].C([C@H]1C[C@H]2O)[C@H](O)CC[C@]1(C)[C@@H]1[C@@H]2[C@@H]2CC[C@H]([C@@H](CCC([O-])=O)C)[C@@]2(C)[C@@H](O)C1 NRHMKIHPTBHXPF-TUJRSCDTSA-M 0.000 description 1
- 239000003549 soybean oil Substances 0.000 description 1
- 235000012424 soybean oil Nutrition 0.000 description 1
- 235000000891 standard diet Nutrition 0.000 description 1
- 239000000126 substance Substances 0.000 description 1
- 239000003440 toxic substance Substances 0.000 description 1
- 125000005457 triglyceride group Chemical group 0.000 description 1
- PHYFQTYBJUILEZ-IUPFWZBJSA-N triolein Chemical compound CCCCCCCC\C=C/CCCCCCCC(=O)OCC(OC(=O)CCCCCCC\C=C/CCCCCCCC)COC(=O)CCCCCCC\C=C/CCCCCCCC PHYFQTYBJUILEZ-IUPFWZBJSA-N 0.000 description 1
- 229940117972 triolein Drugs 0.000 description 1
- 235000015112 vegetable and seed oil Nutrition 0.000 description 1
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- 235000013343 vitamin Nutrition 0.000 description 1
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- 229930003231 vitamin Natural products 0.000 description 1
Classifications
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/135—Bacteria or derivatives thereof, e.g. probiotics
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L29/00—Foods or foodstuffs containing additives; Preparation or treatment thereof
- A23L29/06—Enzymes
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/115—Fatty acids or derivatives thereof; Fats or oils
- A23L33/12—Fatty acids or derivatives thereof
-
- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23L—FOODS, FOODSTUFFS, OR NON-ALCOHOLIC BEVERAGES, NOT COVERED BY SUBCLASSES A21D OR A23B-A23J; THEIR PREPARATION OR TREATMENT, e.g. COOKING, MODIFICATION OF NUTRITIVE QUALITIES, PHYSICAL TREATMENT; PRESERVATION OF FOODS OR FOODSTUFFS, IN GENERAL
- A23L33/00—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof
- A23L33/10—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives
- A23L33/125—Modifying nutritive qualities of foods; Dietetic products; Preparation or treatment thereof using additives containing carbohydrate syrups; containing sugars; containing sugar alcohols; containing starch hydrolysates
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- A—HUMAN NECESSITIES
- A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
- A23V—INDEXING SCHEME RELATING TO FOODS, FOODSTUFFS OR NON-ALCOHOLIC BEVERAGES AND LACTIC OR PROPIONIC ACID BACTERIA USED IN FOODSTUFFS OR FOOD PREPARATION
- A23V2002/00—Food compositions, function of food ingredients or processes for food or foodstuffs
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
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- Life Sciences & Earth Sciences (AREA)
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- Food Science & Technology (AREA)
- Polymers & Plastics (AREA)
- Mycology (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Microbiology (AREA)
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- Medicines Containing Material From Animals Or Micro-Organisms (AREA)
Abstract
The invention belongs to the technical field of probiotic promoters, and discloses a long-chain triglyceride intestinal probiotic promoter in almond oil, and a preparation method and application thereof. The method comprises the following steps: 1) reacting oleum Armeniacae amarum with lipase, and adding C8～C12Continuously reacting the fatty acid, and performing subsequent treatment to obtain long-chain triglyceride in the almond oil; 2) mixing long chain triglyceride in oleum Armeniacae amarum, emulsifier, microcrystalline cellulose and water to obtain oleum Armeniacae amarumIntestinal probiotic promoter containing long chain triglyceride in kernel oil. The intestinal probiotic accelerant can adjust intestinal flora and promote the obvious proliferation of intestinal lactobacillus and bifidobacteria after being orally taken. The intestinal tract probiotic promoter containing long-chain triglyceride in almond oil is used for preparing intestinal tract flora regulating products.
Description
Technical Field
The invention belongs to the technical field of probiotic promoters, and particularly relates to a long-chain triglyceride intestinal probiotic promoter in almond oil, and a preparation method and application thereof.
Background
The intestinal flora is a normal microorganism in the intestinal tract of a host and is of various types. Generally, healthy adults have about 10 microorganisms in their intestines14About 10 times of the number of human cells, can form a complex and unique system in vivo to regulate the normal physiological functions of the host, and the composition, metabolism and the like of the flora are also influenced by the surrounding environment of the host. The intestinal probiotics comprise lactobacillus, bifidobacterium and the like, are indispensable elements for human health, can synthesize various vitamins, participate in the digestion of food, promote the intestinal peristalsis, inhibit the growth of pathogenic flora, decompose harmful and toxic substances and the like. By regulating intestinal flora and increasing probiotics, intestinal diseases caused by various pathogenic bacteria can be inhibited, and metabolism and immunity of human body can be regulated.
The almond has the function of relaxing bowel, and CN104905352A and CN108208504A respectively disclose a preparation method of a health-care drink, which comprises almond raw materials and has the function of regulating intestinal flora, but key components in the almond raw materials are not disclosed. The almond oil accounts for more than 50 percent of the weight of the almonds, and the main fatty acids are oleic acid and linoleic acid, so the almond oil belongs to long-chain triglyceride, has single component and is not beneficial to the regulation of intestinal flora. Medium-and long-chain triglycerides (MLCTs) are formed by binding medium-and long-chain fatty acids to the same glycerol molecule, are excellent biological energy sources, and are substances that control blood glucose and increase the production of ketones in the body, thereby promoting metabolism.
The MLCTs have extremely low natural oil content, and if the almond oil can be changed into the MLCTs, the MLCTs can supply various fatty acids, so that the intestinal flora can be directly regulated, and the proliferation of probiotics is promoted. Such studies have not been reported.
Disclosure of Invention
In order to overcome the defects and shortcomings of the prior art, the invention mainly aims to provide the intestinal probiotic promoter containing long-chain triglyceride in almond oil.
The invention also aims to provide a preparation method of the intestinal probiotic promoter containing long-chain triglyceride in almond oil.
Still another object of the present invention is to provide the use of the long chain triglyceride intestinal probiotic promoter in almond oil for the regulation of intestinal flora.
The purpose of the invention is realized by the following technical scheme.
An intestinal tract probiotic promoter containing long chain triglyceride in almond oil is a liquid or solid preparation which is prepared by taking the long chain triglyceride in the almond oil as an active ingredient and adding an emulsifier, microcrystalline cellulose and water and can promote the proliferation of intestinal tract probiotics; the long chain triglyceride in the almond oil is almond oil and C8～C12Fatty acid is reacted with lipase to produce triglyceride, almond oil and C with different fatty acid chains in the same molecule8～C12The molar ratio of the fatty acid is 1 (1-3).
The preparation method of the intestinal probiotic promoter containing long-chain triglyceride in almond oil comprises the following steps:
1) reacting oleum Armeniacae amarum with lipase, and adding C8～C12Continuously reacting the fatty acid, and performing subsequent treatment to obtain long-chain triglyceride in the almond oil;
2) mixing long-chain triglyceride in almond oil, an emulsifier, microcrystalline cellulose and water to obtain the intestinal probiotic promoter containing the long-chain triglyceride in the almond oil.
The lipase in the step 1) is immobilized lipase; the immobilized lipase is more than one of Lipozyme 435, Lipozyme RMIM and Lipozyme TLIM.
Step 1) said C8～C12The fatty acid is more than one of caprylic acid, capric acid, lauric acid, myristic acid and palmitic acid.
The dosage of the lipase is 5-15% of the mass of the almond oil; the reaction condition is that the reaction is carried out for 1 to 3 hours at the temperature of between 40 and 70 ℃; said almond oil and C8～C12The molar ratio of fatty acid is 1: (1-3).
The continuous reaction time is 5-10 h.
And the subsequent treatment is to filter the reacted system, wash the filtrate by adopting an alkaline compound aqueous solution, stand and layer, and dry the supernatant to obtain the medium-long chain triglyceride of the almond oil. The alkaline compound aqueous solution is a sodium carbonate aqueous solution with the mass fraction of 5-15%; the adding amount of the alkaline compound aqueous solution is 30-50% of the volume of the filtrate; the drying is vacuum drying, and the drying condition is 60-80 ℃ and 0.01-0.1MPa for 5-10 h.
The dosage of long-chain triglyceride, emulsifier, microcrystalline cellulose and water in the almond oil in the step 2) meets the following requirements: the mass percentages are respectively 30-80%, 2-5%, 10-60% and 8-50%.
The emulsifier in the step 2) is one or more of monoglyceride, tween 80 and span 60.
The application of the intestinal tract probiotic promoter containing long-chain triglyceride in almond oil in the preparation of intestinal tract flora regulating products (such as medicines and health-care foods) can promote the obvious proliferation of intestinal tract lactobacillus and bifidobacteria after oral administration, thereby preventing diseases caused by intestinal tract harmful bacteria.
The principle of the invention is as follows: the almond oil is hydrolyzed into fatty acid and glycerin under the action of lipase, and then is mixed with C8～C12Fatty acids are recombined under the action of lipase to generate triglyceride with different fatty acids in the same molecule. The product is hydrolyzed and absorbed in intestinal tract, medium-chain fatty acid can be rapidly decomposed to provide multiple nutrients and energy for beneficial bacteria in organism and intestinal tract, and long-chain fatty acid can be slowly decomposed to maintain metabolic balance, thereby promoting proliferation of beneficial bacteria in intestinal tract and maintaining human health.
Compared with the prior art, the invention has the following advantages and effects:
(1) the long-chain triglyceride in the almond oil prepared by the invention improves multiple effects of the almond oil.
(2) The invention overcomes the defect that almond oil can only provide long-chain fatty acid and can not rapidly provide nutrition and energy of various fatty acids, and can realize the proliferation of beneficial bacteria in intestinal tracts.
(3) The method has mild reaction conditions and is easy for industrial production.
Detailed Description
The present invention will be described in further detail with reference to examples, but the embodiments of the present invention are not limited thereto.
Example 1
(1) Adding immobilized lipase Lipozyme 435 with the mass fraction of 5% into almond oil, reacting for 3 hours at 40 ℃, adding caprylic acid with the molar weight (based on the molecular weight of triolein) 1 time of that of the almond oil, and continuing to react for 5 hours to obtain mixed reaction liquid;
(2) filtering the mixed reaction liquid, adding 30% by volume of sodium carbonate aqueous solution with the mass fraction of 15% into the filtrate, washing, standing for layering, keeping the upper layer, and drying at 60 ℃ under 0.01MPa for 5 hours to obtain long-chain triglyceride in the almond oil;
(3) mixing long-chain triglyceride in the almond oil with 80% of tween, 2% of microcrystalline cellulose and 8% of water by mass, and preparing a liquid preparation, namely the intestinal tract probiotic promoter of the long-chain triglyceride in the almond oil.
Example 2
(1) Adding immobilized lipase Lipozyme RMIM (the manufacturer is Novoxil (China) biotechnology limited) with the mass fraction of 15 percent into almond oil, reacting for 1 hour at 70 ℃, adding capric acid with the molar quantity of 3 times of that of the almond oil, and continuously reacting for 10 hours to obtain mixed reaction liquid;
(2) filtering the mixed reaction liquid, adding 50% by volume of sodium carbonate aqueous solution with the mass fraction of 5% into the filtrate, washing, standing for layering, keeping the upper layer, and drying at 80 ℃ and 0.1MPa for 10 hours to obtain long-chain triglyceride in the almond oil;
(3) mixing long-chain triglyceride in the almond oil with monoglyceride, microcrystalline cellulose and water according to the mass fraction of 30%, 5%, 50% and 15% to prepare a solid preparation, namely the intestinal tract probiotic promoter of the long-chain triglyceride in the almond oil.
Example 3
(1) Adding immobilized lipase Lipozyme TLIM (the manufacturer is Novoxil (China) biotechnology limited) with the mass fraction of 10% into almond oil, reacting for 2 hours at 50 ℃, adding lauric acid with the molar quantity 2 times of that of the almond oil, and continuously reacting for 6 hours to obtain mixed reaction liquid;
(2) filtering the mixed reaction liquid, adding 40% by volume of sodium carbonate aqueous solution with the mass fraction of 10% into the filtrate, washing, standing for layering, keeping the upper layer, and drying at 70 ℃ under 0.05MPa for 8 hours to obtain long-chain triglyceride in the almond oil;
(3) mixing the long-chain triglyceride in the almond oil with span 60, microcrystalline cellulose and water according to the mass fraction of 40%, 3%, 40% and 17% to prepare a solid preparation, namely the intestinal tract probiotic promoter of the long-chain triglyceride in the almond oil.
Example 4
(1) Adding 7% by mass of immobilized lipase Lipozyme 435 (a manufacturer is Novoxil (China) biotechnology limited) into almond oil, reacting for 2.5 hours at 45 ℃, adding myristic acid with the molar quantity 1.5 times that of the almond oil, and continuing to react for 7 hours to obtain a mixed reaction solution;
(2) filtering the mixed reaction liquid, adding 35% by volume of sodium carbonate aqueous solution with the mass fraction of 7% into the filtrate, washing, standing for layering, keeping the upper layer, and drying at 65 ℃ and 0.02MPa for 7 hours to obtain long-chain triglyceride in the almond oil;
(3) mixing long-chain triglyceride in the almond oil with 60 percent, 4 percent, 20 percent and 16 percent of Tween 80, microcrystalline cellulose and water by mass fraction to prepare a liquid preparation, namely the intestinal tract probiotic promoter of the long-chain triglyceride in the almond oil.
Example 5
(1) Adding immobilized lipase RMIM with the mass fraction of 12% into almond oil, reacting for 1.5h at 65 ℃, adding palmitic acid with the molar weight of 2.5 times of that of the almond oil, and continuously reacting for 8h to obtain a mixed reaction solution;
(2) filtering the mixed reaction liquid, adding 45% by volume of sodium carbonate aqueous solution with the mass fraction of 12% into the filtrate, washing, standing for layering, keeping the upper layer, and drying at 75 ℃ under 0.05MPa for 6 hours to obtain long-chain triglyceride in the almond oil;
(3) mixing the long-chain triglyceride in the almond oil with span 60, microcrystalline cellulose and water according to the mass fraction of 50%, 2%, 20% and 28% to prepare a liquid preparation, namely the intestinal tract probiotic promoter of the long-chain triglyceride in the almond oil.
Comparative example 1
The procedure of example 1 was followed except that in step (1) almond oil was replaced with soybean oil and the product produced was control 1.
Comparative example 2
The preparation was as in example 1, but in step (1) almond oil was replaced by peanut oil and the product prepared was control 2.
Comparative example 3
The preparation was carried out as in example 1, except that in step (3) the proportion of long chain triglycerides in the almond oil in the formulation was changed to 20%, and the product obtained was control 3.
Test 1 analysis of the composition of long chain triglycerides in almond oil obtained in examples 1-5
The method comprises the following steps: the long chain triglycerides in the almond oil obtained in examples 1 to 5 were measured for the content of fatty acids in a sample in an appropriate amount according to the first method of determination of fatty acids in food (GB5009.168-2016), which is a national standard for food safety, and converted into a molar ratio.
As a result: the samples obtained in examples 1 to 5 have a number of moles of oleic acid or linoleic acid per mole of long chain triglycerides of 1.8, 0.8, 0.9, 1.7 and 1.0, respectively, while the numbers of moles of caprylic acid, capric acid, lauric acid, myristic acid and palmitic acid are 1.1, 2.1, 1.8, 1.1 and 1.9, respectively, indicating that the long chain triglycerides of the almond oils obtained in examples 1 to 5 are mainly glyceryl monocaprylate (linoleic acid), glyceryl dicaprate monooleate (linoleic acid), glyceryl dilaurate monooleate (linoleic acid), glyceryl monomyristate dioleate (linoleic acid) and glyceryl dipalmitate monooleate (linoleic acid), respectively. Illustrative examples 1-5 successfully prepared long chain triglycerides in almond oil.
Test 2 the effect of long chain triglyceride intestinal probiotic boosters in almond oil prepared in example 1
The method comprises the following steps: 40 male SD rats (250 + -25 g) were randomly divided into 8 groups of 5 rats each. Normal rats were fed with diet of group 1, high fat diet (87.6% standard diet, 2% cholesterol, 0.2% sodium cholate, 10% lard) was fed to group 2, lard was replaced with almond oil in high fat diet was fed to group 3, long chain triglyceride was replaced with the diet of almond oil prepared in example 1 in group 4, long chain triglyceride in almond oil prepared in example 1 was fed to groups 5-8, and then long chain triglyceride in almond oil prepared in example 1 was individually gavaged, intestinal probiotic-promoting agent of control group 1-3, twice a day at a dose of 1g/100g body weight. The rat feces were taken at 15 days and 30 days, respectively, subjected to 16sRNA metagenomic sequencing of the intestinal flora and probiotics (such as bifidobacterium and lactobacillus), and analyzed for abundance (relative percentage) of various probiotics.
As a result: the results are shown in table 1, which shows that the group 2 model rats have significantly reduced probiotics compared with the normal group, and the group 3 and the 6-8 control group have improved probiotics compared with the group 2 but have no difference with the normal group; the probiotics of rats in the 4 th group and the 5 th group are obviously improved compared with the probiotics in the model group and are higher than those in the normal group and the almond oil, so that the long-chain triglyceride in the almond oil has stronger effect of promoting the proliferation of the probiotics than the almond oil and other vegetable oils; the intestinal probiotic accelerant of the medium-long-chain triglyceride of the almond oil has better effect than the medium-long-chain triglyceride of the almond oil and products which are not in the dosage range of the formula, which shows that the formula can play stronger role.
TABLE 1 relative abundance of probiotics in rat feces (%)
The above examples of the present invention are merely examples for clearly illustrating the present invention and are not intended to limit the embodiments of the present invention. Other variations and modifications will be apparent to persons skilled in the art in light of the above description. And are neither required nor exhaustive of all embodiments. Any modification, equivalent replacement, and improvement made within the spirit and principle of the present invention should be included in the protection scope of the claims of the present invention.
Claims (9)
1. An intestinal tract probiotics accelerant of medium-long chain triglyceride of almond oil is characterized in that: is prepared from long-chain triglyceride in oleum Armeniacae amarum as active ingredient, and emulsifier, microcrystalline cellulose, and waterThe liquid or solid preparation can promote the proliferation of the intestinal probiotics; the long chain triglyceride in the almond oil is prepared from almond oil, lipase and C8～C12Triglyceride, almond oil and C prepared from fatty acid and having different fatty acid chains on the same molecule8～C12The molar ratio of the fatty acid is 1 (1-3).
2. The almond oil medium long chain triglyceride intestinal probiotic promoting agent of claim 1 wherein: the long-chain triglyceride, the emulsifier, the microcrystalline cellulose and the water in the almond oil meet the following requirements: the mass percentages are respectively 30-80%, 2-5%, 10-60% and 8-50%.
3. The method for preparing the intestinal probiotic promoter of long-chain triglyceride in almond oil according to any one of claims 1-2, characterized in that: the method comprises the following steps:
1) reacting oleum Armeniacae amarum with lipase, and adding C8～C12Continuously reacting the fatty acid, and performing subsequent treatment to obtain long-chain triglyceride in the almond oil;
2) mixing long-chain triglyceride in almond oil, an emulsifier, microcrystalline cellulose and water to obtain the intestinal probiotic promoter containing the long-chain triglyceride in the almond oil.
4. A method of preparing a long chain triglyceride in almond oil intestinal probiotic promoter according to claim 3, characterized in that: the lipase in the step 1) is immobilized lipase;
step 1) said C8～C12The fatty acid is more than one of caprylic acid, capric acid, lauric acid, myristic acid and palmitic acid.
5. The method of preparing a long chain triglyceride intestinal probiotic promoter in almond oil according to claim 4, wherein:
the immobilized lipase is more than one of Lipozyme 435, Lipozyme RMIM and Lipozyme TLIM.
6. A method of preparing a long chain triglyceride in almond oil intestinal probiotic promoter according to claim 3, characterized in that:
the dosage of the lipase in the step 1) is 5-15% of the mass of the almond oil; the reaction condition is that the reaction is carried out for 1 to 3 hours at the temperature of between 40 and 70 ℃; the continuous reaction time is 5-10 h;
the emulsifier in the step 2) is one or more of monoglyceride, tween 80 and span 60.
7. A method of preparing a long chain triglyceride in almond oil intestinal probiotic promoter according to claim 3, characterized in that: the subsequent treatment in the step 1) is to filter the reacted system, wash the filtrate by adopting an alkaline compound aqueous solution, stand and layer, and dry the supernatant to obtain the long-chain triglyceride in the almond oil.
8. The method of preparing a long chain triglyceride intestinal probiotic promoter in almond oil according to claim 7, wherein: the alkaline compound aqueous solution is a sodium carbonate aqueous solution with the mass fraction of 5-15%; the adding amount of the alkaline compound aqueous solution is 30-50% of the volume of the filtrate; the drying is vacuum drying, and the drying condition is 60-80 ℃, and the drying time is 0.01-0.1MPa for 5-10 h.
9. Use of a long chain triglyceride in almond oil gut probiotic promoter according to any one of claims 1-2, characterised in that: the intestinal tract probiotic promoter containing long-chain triglyceride in almond oil is used for preparing an intestinal tract flora regulating product and promoting the proliferation of intestinal tract lactobacillus and bifidobacteria.
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