CN107712900A - Long-chain fat acid glyceride microcapsules and its production method in a kind of feature - Google Patents

Long-chain fat acid glyceride microcapsules and its production method in a kind of feature Download PDF

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CN107712900A
CN107712900A CN201710996359.2A CN201710996359A CN107712900A CN 107712900 A CN107712900 A CN 107712900A CN 201710996359 A CN201710996359 A CN 201710996359A CN 107712900 A CN107712900 A CN 107712900A
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oil
microcapsules
seed oil
parts
long
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陈华
袁继凤
谭志超
王辉斌
罗会兵
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Bao Rui (hubei) Health Industry Co Ltd
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Bao Rui (hubei) Health Industry Co Ltd
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    • A—HUMAN NECESSITIES
    • A23—FOODS OR FOODSTUFFS; TREATMENT THEREOF, NOT COVERED BY OTHER CLASSES
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    • A23L29/10—Foods or foodstuffs containing additives; Preparation or treatment thereof containing emulsifiers
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    • A23P—SHAPING OR WORKING OF FOODSTUFFS, NOT FULLY COVERED BY A SINGLE OTHER SUBCLASS
    • A23P10/00—Shaping or working of foodstuffs characterised by the products
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Abstract

Long-chain fat acid glyceride microcapsules in a kind of feature, it is made up of plant blend oil, wall material, emulsifying agent, oil phase antioxidant, aqueous phase antioxidant and metal-chelator, heat stabilizer and anticaking agent；30 60 parts of plant blend oil is added in 100 parts of microcapsules；The weight of plant blend oil feed components is：Linseed oil 10 20, oil and fat of sacha inchi 13, Purple Perilla Seed Oil 20 30, peony seed oil 13, Seabuckthorm Seed Oil 13, fiery flaxseed oil 5 10, Boxthorn Seed Oil 5 20, acer truncatum seed oil 12, pumpkin seed oil 10 22, evening primrose oil 37, shea butter 15 and coconut oil 16 21.The advantage of the invention is that there is positive role to reducing blood lipid, improvement insulin resistance, protection cardio-vascular endothelial cells function, prevention coronary heart disease, improvement intestinal immunity barrier, control body weight, prevention breast cancer, prostate cancer, straight colon cancer.

Description

Long-chain fat acid glyceride microcapsules and its production method in a kind of feature
Technical field
The microscapsule powder and its production method for being the present invention relates to a kind of functional plants fat or oil composition, belong to food Manufacture field, more particularly to the answering containing long-chain polyunsaturated fatty acid and medium chain fatty acid of a kind of high fuel load, high stability Close microcapsules and its production technology.
Background technology
In recent years, proportion improves constantly China resident grease intake in the diet, vegetable oil consumption rapid development. Newest scientific research finds, in the past few decades between, although people are to saturated fat, such as lard, butter animal fat Intake constantly reducing, still, the incidence of disease of the chronic disease headed by coronary heart disease, diabetes, cancer, senile dementia is but Still riseing year after year.In the Omega6 excess in meals and Omega3 deficiency, this can make the reason for one of them is important Omega6/Omega3 ratio increase, so it is unbalance.China's dietary survey result in 2002 shows most area resident's meals Middle Omega6/Omega3 ratio is more than 10；China resident eating pattern was progressively westernization in recent years, and this ratio is constantly climbed always Rise, some areas have met or exceeded U.S. Omega6/Omega3 ratio（>20）, this much deviates people from primitive society Most healthy Omega6/Omega3 ratios 1 in class diet：1.
The increase of Omega6/Omega3 ratios can cause proinflammatory factor in human body（Leukotriene LTB4, thromboxane TXA2 and The Eicosanoids Omega6 metabolins such as Prostaglandin PGE2）A large amount of synthesis, the disorder of lipid metaboli enzyme and related gene and The immunization barrier of cell membrane is damaged.Meanwhile Omega6 can also compete cyclooxygenase COX-2 and LOX jointly with Omega3 LOX-5, the metabolic pathway of Omega3 generation anti-inflammatory factors is suppressed, causes inflammatory reaction constantly to aggravate, it is final to induceFertilizer Fat disease, type ii diabetes, atherosclerosis, hypertension, heart disease, NASH, Aging or old silly Slow-witted, arthritis, ulcerative colitis, bronchitis, osteoporosisA series of Metabolic syndrome induced etc. chronic inflammations is levyd Sick rate rises；Long-term chronic inflammation can more trigger canceration.Level of inflammation, especially inflammatory reaction in " cancer microenvironment " in vivo Degree it is directly related to the propagation of cancer cell and invasion and attack.Substantial amounts of research in vivo and in vitro has confirmed that long-term intake is high The cancers such as the edible oil of Omega-6/Omega-3 ratios and breast cancer, oophoroma, prostate cancer, colon cancer are closely related.
At present, both domestic and external learn is carried out to influence of the different Omega3/Omega6 ratios in meals grease to health A large amount of breakthrough research and discussions, and propose Omega3/Omega6 ratios appropriate in meals, rather than these aliphatic acid Single concentration, control blood fat, cardiovascular and cerebrovascular diseases, immunological diseases, insulin resistance, obesity, growth of cancer cells, cranial nerve are developed And visual performance etc. has even more important meaning.So far recommendation ratio of the various countries nutritionist on Omega6/Omega3 Not yet reach common understanding.FAO (Food and Agriculture Organization of the United Nation)（FAO）Recommendation ratio is 5-10：Ratio is suitable in 1, with human breast milk.2001 Chinese Soclety of Nutrition proposes that Omega6/Omega3 suitable proportion should be controlled 4：1 to 6：Between 1.The World Health Organization proposes Omega6/Omega3 ratios should be less than 6：1.International aliphatic acid and lipid EASD（ISSFAL）Recommend, in order to protect painstaking effort The daily minimum intake 500g Omega3 of pipe health；Daily recommendation intake is Omega6 4.0g, Omega3 1.9g.And Australia is big Leah national health and Med Res Co（NHMRC）It is Omega6 10.9g, Omega3 1.4g to recommend daily intake. Australian National heart foundation（NHFA）Recommend to protect cardiovascular health, daily recommendation Omega3 intake is 2.5g.US Experts ad hoc working group suggest that the dosage standard of adult is that Omega6/Omega3 ratios are 2.3：1.American heart It is 1 that sick association expert, which recommends suitable Omega6/Omega3 ratios,:1-4:1.Japanese ministry of Health and Welfare proposes Omega6/Omega3 It should be less than 4：1.Since 2010, international nearest scientific research result also confirms the ratio for reducing Omega6/Omega3 again and again Value, risen rather than just the absolute intake for improving Omega3 in terms of the prevention and treatment of many chronic diseases positive and effective Effect；And supplement Omega6 merely and give no thought to Omega3 or only take in the Omega3 of trace（Omega6/Omega3 mistakes It is high）The risk of sugar and fat metabolism, increase coronary heart disease, hyperlipemia, II- patients with type Ⅰ DM, breast cancer etc. may then be upset.
Influence and its Study on Molecular Mechanism report to lipid metabolism in rats, n- are formed according to document different dietary fatty acid 6/n-3 is 1：The triglycerides and cholesterol level in liver and blood can be significantly reduced when 1.Document difference n-6/n-3 is more not The high fat load meals of saturated fatty acid ratio postprandial glycolipid metabolism is influenceed and antiatherosclerosis Mechanism Study in report, low ratio Value, especially n-6/n-3 are 1：The occurrence and development of high triglyceride patient's atherosclerosis, and low ratio can be prevented when 1 Compare ratios（N-6/n-3 is 10:1）With middle ratio（N-6/n-3 is 5:1）It more can effectively reduce intracellular cholesteryl and courage is consolidated Alcohol ester, its antiinflammatory action are more notable.Different proportion n-6/n-3 polyunsaturated fatty acids are formed to mammary gland carcinogenesis in document meals Pointed out in the influence of development and Study on Molecular Mechanism, n-6/n-3 is formed than being higher than 5：Breast cancer cell can be remarkably promoted when 1 Propagation, and promote effect to increase with n-6/n-3 ratios and strengthen, and n-6/n-3 ratios are equal to and less than 1：When 1, can significantly it press down The propagation of breast cancer cell processed, and effectively induce its apoptosis.
The conventional edible oil of Chinese residents ordinary meal, such as sunflower oil, peanut oil, safflower oil, corn oil, olive oil, And small kind health-care oil, in such as wheat-germ oil, sesame oil, rice bran oil, linoleic acid（Omega6）Account for and definitely dominate, and Alpha-linolenic acid（Omega3）General lack of or missing.As can be seen here, it is common single oil that Omega6/Omega3 ratio is higher Kind self-defect, only reasonably combined Omega6/Omega3 ratio, reduce Omega6/Omega3 ratio to close to 1： 1, profit and the evil of balanced fatty are only the key that science eats oil.
In addition, the aliphatic acid taken in diet is mainly the long chain fatty acids that carbon number is more than more than 12, and carbon Medium chain fatty acid intake of the atomicity between 6-12 is seldom.Medium-chain fatty glyceride（MCT）In physical characteristic, digestion Absorb, be metabolized in vivo etc. and long-chain fat acid glyceride（LCT）It is very different.Works of the LCT in enteral pancreatic lipase Under, the mono- glyceride of 1 2- and 2 free fatties are hydrolyzed to.It is micro- that 2- monoglycerides and fatty acid emulsifier form bile salt Micelle and absorbed by small intestinal mucosa cell, by the ester of synthetic glycerine three again in small intestinal mucosa cell, form chylomicron and pass through Lymphatic system flows into blood, transports adipose tissue, muscle, liver and is further metabolized and utilized.And MCT is in tongue fat It can be aliphatic acid and glycerine by complete hydrolyzable in the presence of enzyme, gastric lipase, hydrolyze the medium chain fatty acid chain of generation no longer The ester of synthetic glycerine three, it is most directly to be inhaled by enteron aisle fine hair after bile salt emulsifies in the form of free fatty Receive, people's blood circulation is entered by portal vein, is transported to liver, into mitochondria after energized by rapid oxidation, it may be said that MCT is several It can be aoxidized, not accumulated by liver cell completely, it enters the process of mitochondrial membrane and carnitine transfer is limited to unlike LCT Enzyme, so it absorbs and aoxidized quicker, quick function, the demand to blood glucose is reduced, while fat will not be brought in vivo Accumulation.
MCT intake can also reduce the level of triglycerides in blood, and improve the metabolism of apolipoprotein, effectively drop Low LDL-C, and help to reduce the accumulation of interior fat and subcutaneous fat.In a word, MCT has rapid Absorption decompose produce energy, accelerate lipolysis, pre- preventing obesity the features such as, be a kind of bioactivity lipid, be also considered as A kind of grease that can lose weight, is more and more applied to the nutritional support of clinical patient, and spy cures food or as health-care oil Fat is used for daily culinary art.Compared with LCT, MCT can also improve insulin sensitivity, and II- diabetes mellitus types intake MCT can change The glucose metabolism of kind insulin-mediated, diabetes patient's use is especially suitable for, can effectively improve muscle, liver and adipose tissue Insulin resistance.But medium chain fatty acid is not essential fatty acid, so long-chain necessary to diet intake also needs to supplement is more Unrighted acid.Further, since it is solid-state under its normal temperature, this brings inconvenience to daily consumption.
MCT main sources are coconut oil, and its content in coconut oil is up to 66%, and coconut oil accounts for world's grease production The 1/10 of amount.Also containing abundant MCT in the breast of some animals, as MCT contents are up to 50% in the breast of rabbit and rat.From 19 The fifties in century begins to, and MCT begins to be applied to the treatment of human adipose's malabsorption disease and LCT dysoxidations.At present, MCT can treat human obesity, insulin resistance, cardiovascular and cerebrovascular diseases etc..
The present invention foundation be：（1）Take into full account reduce Omega6/Omega3 ratios to lipid metaboli, inflammatory reaction, itself Immune, angiocardiopathy, obesity, diabetes, colitis, and the beneficial effect of breast cancer etc., a variety of health of science collocation are pure Vegetable fat, make its Omega6：Omega3 is 1-4：1, thus strengthen feature of the essential fatty acid in terms of prevention and treatment of chronic diseases Effect；（2）MCT introducing compensate for deficiencies of the LCT in terms of energy is quickly provided to a certain extent, and MCT can also promote to grow The oxidative metabolism of chain fatty acid, avoid its accumulation in the tissue and related Insulin resistance；（3）Table is studied Bright, the LCT of equivalent is replaced with MCT to be helped to reduce whole body and local fat deposition, is reduced waist-to-hip ratio, is further improved pancreas Island element resistance；（4）The slightly higher grease of general fusing point（Saturated fatty acid is in the majority, is solid-state under normal temperature）, such as MCT and shea butter, When its microscapsule powder runs into cold-water solution, surface wall material rehydration, but be difficult to discharge, dissolubility is undesirable；And fusing point is relatively low Grease, as the liquid vegetable oil more than polyunsaturated fatty acid can cause grease easily to be infiltrated from wall material, cause microcapsules Surface oil is higher, influences its dissolution dispersity and stability（Fat floats after causing rehydration）, therefore, can by the two collocation use So that hard fat fixes liquid oil, embedding efficiency is improved, improves fuel load, strengthening stability；（5）MCT is in normal temperature and low The state of solidification can be all showed under temperature, the phenomenon that can cause to separate out, be layered directly is mixed with LCT, and microencapsulation technology can So that effectively grease embedding to be got up, more convenient, stable formulation is converted into, daily supplement is become more convenient and various Change；（6）Microcapsules on the market or the puzzlement of powdered oil generally existing hot water rehydration rear stability difference, show as oil slick, divide Layer, have conjunctiva or have granular sensation or sandy sense, fuel load is higher, and oil slick is more serious, and cold water-soluble is bad, it is of the invention then Solve the above problems.
The content of the invention
What the microcapsule product of the essential fatty acid and medium chain fatty acid that supplement scientific matching simultaneously in the market lacked Present situation, with reference to both at home and abroad on reducing Omega6/Omega3 ratios to 1-4：1, especially 1：1 can effectively prevent, suppresses or control The Experimental report for a variety of metabolic syndromes even cancer that inflammation processed triggers, the present inventor complete the present invention, have filled up this Item product blank.
Microcapsules production method of the present invention solves the lance between existing microcapsules fuel load and rehydration stability Shield, fuel load is both improved, in turn ensure that microcapsules after rehydration, especially the long-term stability after hot water redissolution, be presented as Without oil slick, without conjunctiva, without layering, without granular sensation or sandy sense；Low-temperature instant effect might as well simultaneously.
The present invention by plant blend oil, wall material, emulsifying agent, oil phase antioxidant, aqueous phase antioxidant and metal-chelator, Heat stabilizer and anticaking agent composition；
Added in 100 parts of microcapsulesPlant blend oil30-60 parts；The weight of plant blend oil feed components is： Linseed oil 10-20, oil and fat of sacha inchi 1-3, Purple Perilla Seed Oil 20-30, peony seed oil 1-3, Seabuckthorm Seed Oil 1-3, fiery flaxseed oil 5-10, Boxthorn Seed Oil 5-20, acer truncatum seed oil 1-2, pumpkin seed oil 10-22, evening primrose oil 3-7, shea butter 1-5 and coconut oil 16- 21。
It is describedWall materialIt is made up of lactoprotein, maltodextrin, converted starch, malt syrup, wall material renovation agent and hydrophilic colloid, Its weight is：Lactoprotein 25-35, maltodextrin 7-12, converted starch 3-10, malt syrup 3-8, wall material renovation agent 1- 5th, hydrophilic colloid 0.05-1, water 122-133.
It is describedEmulsifying agent isLecithin, Quillaia saponaria bark extract, list, diglycerine fatty acid ester, diacetyl tartarate list are double sweet One or more mixtures in grease, stearoyl lactate, sucrose ester, contain 0.4-6 parts in every 100 parts of plant blend oils Emulsifying agent.
It is describedOil phase antioxidantFor theaflavin, tea polyphenol-palmitate, ascorbyl palmitate, rosemary extraction One or more of mixtures in thing, natural tocopherol, resist containing 0.09-0.14 part oil phases in every 100 parts of plant blend oils Oxidant.
It is describedAqueous phase antioxidantFor one or more mixtures in natural complex C, sodium iso-vc, Tea Polyphenols, often Contain 0.04-1 part aqueous phase antioxidants in 100 parts of microcapsules；
It is describedMetal-chelatorFor in calgon, potassium metapbosphate, sodium pyrophosphate, citric acid, tartaric acid, gluconic acid One or more mixtures, contain 0.25-1 parts in every 100 parts of microcapsulesMetal-chelator；
It is describedHeat stabilizerFor sodium tripolyphosphate and the mixture of dipotassium hydrogen phosphate, contain 0.5-2 parts in every 100 parts of microcapsulesHeat Stabilizer, the two ratio is 1：4-8；
It is describedAnticaking agentFor silica, contain 0.4-0.7 part anticaking agents in every 100 parts of microcapsules.
In described plant blend oil, the weight of long chain fatty acids is：Saturated fatty acid 6-10 parts are single unsaturated Aliphatic acid 12-17 parts, Omega6 essential fatty acid 25-36 parts, Omega3 essential fatty acid 19-30 parts；Omega3 and Omega6 The ratio of polyunsaturated fatty acid is 1：2 or 1：1.
In described plant blend oil, long-chain fat acid glyceride is linseed oil, oil and fat of sacha inchi, Purple Perilla Seed Oil, tree peony It is any in seed oil, Seabuckthorm Seed Oil, fiery flaxseed oil, Boxthorn Seed Oil, acer truncatum seed oil, pumpkin seed oil, evening primrose oil, shea butter Combination；Also can be selected algae oil, walnut oil, borage oil, safflower oil, hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil, Cranberry seed oil, pine-seed oil, One or more of mixtures in samara oil, gamma-Linolenic acid, CLA, grape-kernel oil, eucommia ulmoides seed oil.
In described plant blend oil, medium-chain fatty glyceride is coconut oil.
The weight of each raw material components is in described plant blend oil：Linseed oil 15, oil and fat of sacha inchi 2, purple perilla Seed oil 23, peony seed oil 2, Seabuckthorm Seed Oil 3, fiery flaxseed oil 8, Boxthorn Seed Oil 10, acer truncatum seed oil 1, pumpkin seed oil 12, oenothera biennis Oil 5, shea butter 3, coconut oil 17.
Acid value≤1 of described grease（KOH mg/g）, peroxide value≤0.13（G/100g, with buttermeter）.
The preparation method of plant blend oil is as follows：Under nitrogen protective condition, each grease is proportionally added into mixing In tank, at 35-40 °C of temperature, condition of normal pressure, stirred 20-60 minutes with 60r/min speed, filtering, planted after standing Thing ready-mixed oil.
Wall material renovation agent in the wall material is the dietary fiber of small molecule, lactose, sucrose, trehalose, L-arabinose, One or more mixing in D-sorbite, xylitol；Dietary fiber be resistant dextrin, inulin, stachyose, FOS, Any combination of galactooligosaccharide, oligoisomaltose；Hydrophilic colloid in the wall material is xanthans, flaxseed gum, Pu Lu One or more mixing of blue polysaccharide, Arabic gum.
Processing method is：
It is prepared by aqueous phase：First hydrophilic colloid, heat preservation for standby use are fully dissolved with 70 °C of part hot water；With part aqueous solution metal-chelating Agent, it is stand-by；With aqueous phase tank, lactoprotein, converted starch are charged first in 50-65 °C of hot water, are incubated, stirring is allowed to completely molten Solution, maltodextrin, malt syrup and wall material renovation agent are added, 50-65 °C of insulation, being sufficiently stirred mixes wall material dissolving, adds Enter pre- solvent hydrophilic colloid；Then it is cooled to 45-55 °C；Finally pre- solvent metal-chelator and aqueous phase antioxidant are added Enter into aqueous phase tank, obtain aqueous phase；
It is prepared by oil phase：First vegetable oil is reconciled and is added to oil phase tank, 50-65 °C is slowly heated to, first adds emulsifying agent, insulation makes Emulsifying agent is completely dissolved, and is then cooled to 40 °C, adds oil phase antioxidant, and stirring is allowed to fully dissolve, and obtains oil phase；
The preparation of colostric fluid：Aqueous phase is first pumped into emulsion tank, 48-52 °C of insulation, while opens stirring and high speed shear, then Oil phase is slowly added into emulsion tank, cuts 20-40 minutes at a high speed, and keeps -20--50mPa vacuum, obtains colostric fluid；
It is prepared by emulsion：Using secondary pressure homogenizer to colostric fluid carry out homogeneous, homogeneous 2-3 times, homogenization pressure 40-65Pa, Obtain emulsion；
Sterilizing：Using ultra high temperature short time sterilization machine to step（4）Obtained emulsion sterilizes 10-15s under 108-135 °C, discharging Temperature is 60-70 °C；
Spray drying：EAT is 165-180 °C, and leaving air temp is 85-90 °C, then passes through fluid bed and gathers again, obtains micro- Capsule powders；
Mixed powder sieving：Anticaking agent is added to step（6）In obtained microscapsule powder, it is well mixed, crosses 20 mesh or 40 mesh shake Dynamic sieve, obtained microcapsules；
Packaging：By step（7）Obtained microcapsules, load PE inner bags, first vacuumize, backfill nitrogen afterwards, by metal detection After instrument, load aluminium foil bag, obtain finished product；
Can be by step（8）Granule or capsule is made using conventional formulation method in gained microcapsules.
The step（1）Middle amount of water is calculated by emulsion solid content 30-45%；Temperature control is at 50-60 ° in homogenizing process C；Material after sterilizing temperature to be painted is 50-60 °C；Spray drying tower is upper air-out Spray Grain-make Drier, and atomizer is pressure Power atomizer；Material after sterilizing is forced into spray drying tower by high-pressure pump, and high pressure pump pressure is 8-15mPa；For fluid bed Temperature is 40-70 °C.
The advantage of the invention is that：
(1) the advantages of grease of the invention combines long-chain polyunsaturated fatty acid and medium chain fatty acid, can be with comprehensive offer Have the healthy grease of feature and nutrition concurrently, especially to reducing blood lipid, improve insulin resistance, protection cardio-vascular endothelial cells work( , can prevent coronary heart disease, improvement intestinal immunity barrier, control body weight, prevention breast cancer, prostate cancer, straight colon cancer has product Pole acts on.
(2) grease of the present invention is the vegetable oil by mediation, solve in general Vegetable Oils Omega3 and The unsound problem of Omega6 polyunsaturated fatty acid ratios, makes the ratio of the two reach 1：1-4, closer to Chronic disease prevention and Cancer, protect the proper ratio required for health.
(3) microcapsule raw auxiliary material of the invention is food additives, though it is high in fuel load, and majority is how unsaturated fat Fat acid esters, but be free of chemical synthesis antioxidant（Such as TBHQ, BHA, BHT）, but natural composite antioxidant is selected, improve production The product shelf time limit.
(4) in order to solve the problems, such as high easy oil slick after carrying oil microcapsule rehydration, it is excellent that present invention innovation employs emulsifiability Natural phosphatidyl choline more and the natural component as food additives new varieties --- Quillaia saponaria bark extract, wherein, lecithin is not Only play a part of stable emulsifying oil droplet, itself be also it is a kind of well protection brain and nervous system health activity into Point；Traditional microcapsules are avoided to chemical synthesis emulsifying agent, such as single, bis-fatty acid glyceride, sucrose ester, polyglycerol fatty acid The dependence of ester, stearoyl lactate, Tween 80 etc..Numerous studies have shown that it is eaten for a long time containing chemical synthesis emulsifying agent Processed food, can trigger chronic enteritis, cause gut barrier dysfunction, the digestion and immunologic function to human body are unfavorable.
(5) natural the compound emulsifying agent lecithin and Quillaia saponaria bark extract that use of the present invention, and using casein sodium as Main compound wall materialses can improve the high hydrophily for carrying oil microcapsule cyst wall, make particle small and be distributed homogeneous；Thus meeting it To low temperature particularly cold water（25°C）Can also fully be discharged when reconstituting, rapid dispersion, after product rehydration emulsion particle diameter it is small and It is homogeneous, reduce or prevent fatty floating, it is not stratified, without conjunctiva；Avoiding traditional microcapsules needs hot water just to be filled as thermal source Point dissolving and the deficiency of release grease, the characteristics of meeting hot and cold water and molten, rapid dispersion.
(6) present invention uses casein sodium and converted starch as main wall material, while with the addition of wall material renovation agent, i.e., small The inserts of molecule, including dietary fiber（Resistant dextrin, inulin, stachyose etc.）, small sugar（Such as lactose, sucrose, trehalose, L- Arabinose）, sugar alcohol（D-sorbite, xylitol）Deng one or more compositions, it can cooperate with full together with grease Sufficient consumer to control blood-fat and blood sugar and the needs of body weight, strengthen the compactness of wall material, improve the glass transition of wall material by and can Temperature, moreover it is possible to lift mouthfeel and taste.
(7) hydrophilic colloid that the present invention is added（Xanthans etc.）Cyst wall compactness, the resistance of microcapsules can further be improved Oxygen, water preventing ability；Can also increase simultaneously it is high-pressure homogeneous after the obtained viscosity of emulsion, for forming big in spray-drying process Droplet is highly beneficial, it is possible thereby to obtain larger granularity, increases the particle diameter of emulsion after rehydration, improves microscapsule powder Mobility and instant capacity；Simultaneously because xanthans has certain thickening power, emulsion stability after rehydration can be improved, reduced Coalescence or the possibility to float occur for reconstituted milk.
(8) microscapsule powder of the invention can realize hot water or cold water and molten, and dissolving is rapid, hot water（85°C）Reconstituting also can be real Existing fabulous stability, reconstituted milk state after not stratified, fat-free floating, dissolving is homogeneous, without sand type and mellow in taste.
(9) advantage of the invention with most of microcapsules manufacture crafts also resides in, and technique involved in the present invention is without height Warm process, from the aqueous phase of pretreatment stage and the preparation of oil phase, air intake and leaving air temp to spray drying are all controlled relative Low level, at utmost avoid the destruction of the Oxidation of Fat and Oils and active component of high-temperature induction；It it also avoid wall material and U.S. occur Maillard reaction.
(10) of the present invention is upper air-out spray granulating and drying tower, i.e.,：Particle after the atomization drying quilt in tower Upward air inducing traction, meets with the drop of rear atomization and the fine powder of other suspensions, soaks again, sticks into bulky grain reunion Body, re-dry, repeated multiple times on this basis, is increased to unit weight and is enough to fall it, and thus the microscapsule powder of gained is thin Powder ratio is small, and granularity is big and homogeneous, has been not easy electrostatic, all favourable to follow-up mixed powder, sieve powder, packaging.
(11) microcapsules of the present invention are excellent health product raw materials, can be widely applied to health products, dairy products, consolidate Body beverage, capsule etc..
Figure of description
Fig. 1 is present invention process flow chart.
Embodiment
Formed because the microcapsules designed by the present invention are reconciled by various plants oil, by kind, the place of production, extraction process etc. Influence, the Fatty acid compositions of every kind of grease have fluctuation, therefore supplied materials should be detected before manufacture, to ensure ready-mixed oil Omega3 and Omega6 is optimal proportion 1 in grease：1-2.
Embodiment 1.
(1) long-chain fat acid glyceride microcapsules in a kind of feature, its grease by the component compatibility of following parts by weight and Into：Linseed oil 15, oil and fat of sacha inchi 2, Purple Perilla Seed Oil 23, peony seed oil 2, Seabuckthorm Seed Oil 3, fiery flaxseed oil 8, Boxthorn Seed Oil 10, Acer truncatum seed oil 1, pumpkin seed oil 12, evening primrose oil 5, shea butter 3, coconut oil 17；Oil wherein after the mediation of the present embodiment Contain 28.1 parts of Omega3 essential fatty acids, 28.2 parts of Omega6 essential fatty acids in fat, the two ratio is 1：1.
(2) under nitrogen protection, the good grease of above compatibility is added into blending tank, in 35-40 °C of temperature, condition of normal pressure Under, stirred 40 minutes with 60r/min speed, obtained after filtering.
(3) long-chain fat acid glyceride microcapsules in a kind of feature, in terms of weight part ratio, the raw material proportioning of the microcapsules It is as follows：
(4) long-chain fat acid glyceride microcapsule preparation method is as follows in a kind of feature：
1st, prepared by aqueous phase：First hydrophilic colloid, heat preservation for standby use are fully dissolved with 70 °C of part hot water；With part aqueous solution metal-chelating Agent, it is stand-by；With aqueous phase tank, lactoprotein, converted starch are charged first in 65 °C of hot water, are incubated, stirring is allowed to be completely dissolved, then Maltodextrin, malt syrup and wall material renovation agent are added, 65 °C of insulations, being sufficiently stirred mixes wall material dissolving, adds pre- solvent Hydrophilic colloid, be then cooled to 50 °C；Finally metal-chelator and aqueous phase antioxidant are added in aqueous phase tank, obtain water Phase.
2nd, prepared by oil phase：Grease is first added to oil phase tank, is slowly heated to 60 °C, first adds emulsifying agent, insulation makes breast Agent is completely dissolved, and is then cooled to 40 °C and is added oil phase antioxidant, stirring is allowed to fully dissolve, and obtains oil phase.
3rd, the preparation of colostric fluid：Aqueous phase is first pumped into emulsion tank, 50 °C of insulations, opens stirring and high speed shear, then Oil phase is slowly added into emulsion tank, cut at a high speed 40 minutes, and keeps certain vacuum degree, obtains colostric fluid.
4th, homogeneous：Homogeneous is carried out to colostric fluid using secondary pressure homogenizer, homogeneous 2 times, homogenization pressure 53MPa, obtained To emulsion.
5th, sterilize：Sterilized using the emulsion that ultra high temperature short time sterilization machine obtains to step 4 under 110 °C 15s.
6th, it is spray-dried：EAT is 175 °C, and leaving air temp is 84 °C, then passes through fluid bed and gathers again, obtains micro- glue Capsule powder.
7th, powder sieving is mixed：Silica is added in the microscapsule powder that step 6 obtains, be well mixed, crossed 20 mesh and shake Dynamic sieve.
8th, pack：The microcapsules obtained by step 7, load PE inner bags, first vacuumize, backfill nitrogen afterwards, by metal After survey meter, load aluminium foil bag, obtain finished product.
Embodiment 2.
(1) long-chain fat acid glyceride microcapsules in a kind of feature, its grease by the component compatibility of following parts by weight and Into：Linseed oil 12, Purple Perilla Seed Oil 16, Seabuckthorm Seed Oil 2, fiery flaxseed oil 5, Boxthorn Seed Oil 16, pumpkin seed oil 18, acer truncatum seed oil 2nd, the required fat of Omega3 is contained in the grease after evening primrose oil 4, shea butter 4, and coconut oil 21, the wherein mediation of the present embodiment 20.4 parts of fat acid, 30.8 parts of Omega6 essential fatty acids, the two ratio is 1：1.5.
(2) under nitrogen protection, the good grease of above compatibility is added into blending tank, in 35-40 °C of temperature, condition of normal pressure Under, stirred 30 minutes with 60r/min speed, obtained after filtering.
(3) long-chain fat acid glyceride microcapsules in a kind of feature, in terms of weight part ratio, the raw material proportioning of the microcapsules It is as follows：
(4) long-chain fat acid glyceride microcapsule preparation method is as follows in a kind of feature：
1st, prepared by aqueous phase：First hydrophilic colloid, heat preservation for standby use are fully dissolved with 70 °C of part hot water；With part aqueous solution metal-chelating Agent, it is stand-by；With aqueous phase tank, lactoprotein, converted starch are charged first in 65 °C of hot water, are incubated, stirring is allowed to be completely dissolved, then Maltodextrin, malt syrup and wall material renovation agent are added, 65 °C of insulations, being sufficiently stirred mixes wall material dissolving, is then cooled to 50°C；Finally pre- solvent hydrophilic colloid, metal-chelator and aqueous phase antioxidant are added in aqueous phase tank, obtain aqueous phase.
2nd, prepared by oil phase：Grease is first added to oil phase tank, is slowly heated to 60 °C, first adds emulsifying agent, insulation makes breast Agent is completely dissolved, and is then cooled to 40 °C and is added oil phase antioxidant, stirring is allowed to fully dissolve, and obtains oil phase.
3rd, the preparation of colostric fluid：Aqueous phase is first pumped into emulsion tank, 50 °C of insulations, opens stirring and high speed shear, then Oil phase is slowly added into emulsion tank, cut at a high speed 40 minutes, and keeps certain vacuum degree, obtains colostric fluid.
4th, homogeneous：Homogeneous is carried out to colostric fluid using secondary pressure homogenizer, homogeneous 2 times, homogenization pressure 55MPa, obtained To emulsion.
5th, sterilize：Sterilized using the emulsion that ultra high temperature short time sterilization machine obtains to step 4 under 109 °C 15s.
6th, it is spray-dried：EAT is 170 °C, and leaving air temp is 85 °C, then passes through fluid bed and gathers again, obtains micro- glue Capsule powder.
7th, powder sieving is mixed：Silica is added in the microscapsule powder that step 6 obtains, be well mixed, crossed 40 mesh and shake Dynamic sieve.
8th, pack：The microcapsules obtained by step 7, load PE inner bags, first vacuumize, backfill nitrogen afterwards, by metal After survey meter, load aluminium foil bag, obtain finished product.
Embodiment 3.
Long-chain fat acid glyceride microcapsules in a kind of feature, its grease are formed by the component compatibility of following parts by weight： Linseed oil 10, Purple Perilla Seed Oil 15, Seabuckthorm Seed Oil 1, fiery flaxseed oil 5, Boxthorn Seed Oil 20, pumpkin seed oil 22, acer truncatum seed oil 1, Contain the required fat of Omega3 in grease after evening primrose oil 47, shea butter 1, and coconut oil 16, the wherein mediation of the present embodiment 18.8 parts of fat acid, 36.7 parts of Omega6 essential fatty acids, the two ratio is 1：2.Under nitrogen protection, by the good oil of above compatibility Fat adds blending tank, at 35-40 °C of temperature, condition of normal pressure, is stirred 20 minutes with 60r/min speed, is obtained after filtering.
Long-chain fat acid glyceride microcapsules in a kind of feature, in terms of weight part ratio, the raw material proportioning of the microcapsules is such as Under：
Long-chain fat acid glyceride microcapsule preparation method is as follows in a kind of feature：
1st, prepared by aqueous phase：First hydrophilic colloid, heat preservation for standby use are fully dissolved with 70 °C of part hot water；With part aqueous solution metal-chelating Agent, it is stand-by；With aqueous phase tank, lactoprotein, converted starch are charged first in 63 °C of hot water, are incubated, stirring is allowed to be completely dissolved, then Maltodextrin, malt syrup and wall material renovation agent are added, 60 °C of insulations, being sufficiently stirred mixes wall material dissolving, adds pre- solvent Hydrophilic colloid；Then 55 °C are cooled to；Pre- solvent metal-chelator and aqueous phase antioxidant are finally added to aqueous phase tank In, obtain aqueous phase.
2nd, prepared by oil phase：Grease is first added to oil phase tank, is slowly heated to 65 °C, first adds emulsifying agent, insulation makes breast Agent is completely dissolved, and is then cooled to 40 °C and is added oil phase antioxidant, stirring is allowed to fully dissolve, and obtains oil phase.
3rd, the preparation of colostric fluid：Aqueous phase is first pumped into emulsion tank, 55 °C of insulations, opens stirring and high speed shear, then Oil phase is slowly added into emulsion tank, cut at a high speed 30 minutes, and keeps certain vacuum degree, obtains colostric fluid.
4th, homogeneous：Homogeneous is carried out to colostric fluid using secondary pressure homogenizer, homogeneous 2 times, homogenization pressure 48MPa, obtained To emulsion.
5th, sterilize：Sterilized using the emulsion that ultra high temperature short time sterilization machine obtains to step 4 under 108 °C 15s.
6th, it is spray-dried：EAT is 165 °C, and leaving air temp is 85 °C, then passes through fluid bed and gathers again, obtains micro- glue Capsule powder.
7th, powder sieving is mixed：Silica is added in the microscapsule powder that step 6 obtains, be well mixed, crossed 40 mesh and shake Dynamic sieve.
8th, pack：The microcapsules obtained by step 7, load PE inner bags, first vacuumize, backfill nitrogen afterwards, by metal After survey meter, load aluminium foil bag, obtain finished product.

Claims (10)

1. long-chain fat acid glyceride microcapsules in a kind of feature, it is characterised in that it is by plant blend oil, wall material, emulsification Agent, oil phase antioxidant, aqueous phase antioxidant and metal-chelator, heat stabilizer and anticaking agent composition；
Plant blend oil 30-60 parts are added in 100 parts of microcapsules；The weight of plant blend oil feed components is： Linseed oil 10-20, oil and fat of sacha inchi 1-3, Purple Perilla Seed Oil 20-30, peony seed oil 1-3, Seabuckthorm Seed Oil 1-3, fiery flaxseed oil 5-10, Boxthorn Seed Oil 5-20, acer truncatum seed oil 1-2, pumpkin seed oil 10-22, evening primrose oil 3-7, shea butter 1-5 and coconut oil 16- 21；
The wall material is made up of lactoprotein, maltodextrin, converted starch, malt syrup, wall material renovation agent and hydrophilic colloid, and its is heavy Amount part, which matches, is：Lactoprotein 25-35, maltodextrin 7-12, converted starch 3-10, malt syrup 3-8, wall material renovation agent 1-5, parent Hydrocolloid 0.05-1, water 122-133；
The emulsifying agent be lecithin, Quillaia saponaria bark extract, list, diglycerine fatty acid ester, diacetyl tartarate list double glyceride, One or more mixtures in stearoyl lactate, sucrose ester, emulsified containing 0.4-6 parts in every 100 parts of plant blend oils Agent；
The oil phase antioxidant is theaflavin, tea polyphenol-palmitate, ascorbyl palmitate, Rosmarinus officinalis extract, day One or more of mixtures in right tocopherol, it is anti-oxidant containing 0.09-0.14 part oil phases in every 100 parts of plant blend oils Agent；
The aqueous phase antioxidant is natural complex C, one or more mixtures in sodium iso-vc, Tea Polyphenols, every 100 parts Contain 0.04-1 part aqueous phase antioxidants in microcapsules；
The metal-chelator is in calgon, potassium metapbosphate, sodium pyrophosphate, citric acid, tartaric acid, gluconic acid One or more mixtures, contain 0.25-1 part metal-chelators in every 100 parts of microcapsules；
The heat stabilizer is the mixture of sodium tripolyphosphate and dipotassium hydrogen phosphate, contains 0.5-2 parts heat in every 100 parts of microcapsules Stabilizer, the two ratio are 1：4-8；
The anticaking agent is silica, and 0.4-0.7 part anticaking agents are contained in every 100 parts of microcapsules.
2. long-chain fat acid glyceride microcapsules in a kind of feature according to claim 1, it is characterised in that：Described In plant blend oil, the weight of long chain fatty acids is：Saturated fatty acid 6-10 parts, monounsaturated fatty acids 12-17 parts, Omega6 essential fatty acid 25-36 parts, Omega3 essential fatty acid 19-30 parts；Omega3 and Omega6 polyunsaturated fatty acids Ratio be 1：2 or 1：1.
3. long-chain fat acid glyceride microcapsules in a kind of feature according to claim 1 or 2, it is characterised in that：Institute In the plant blend oil stated, long-chain fat acid glyceride is linseed oil, oil and fat of sacha inchi, Purple Perilla Seed Oil, peony seed oil, seabuckthorn seeds Any combination in oily, fiery flaxseed oil, Boxthorn Seed Oil, acer truncatum seed oil, pumpkin seed oil, evening primrose oil, shea butter；It is also optional With algae oil, walnut oil, borage oil, safflower oil, hippophae rhamnoides fruit oil, Seabuckthorm Seed Oil, Cranberry seed oil, pine-seed oil, samara oil, γ- One or more of mixtures in leukotrienes, CLA, grape-kernel oil, eucommia ulmoides seed oil.
4. long-chain fat acid glyceride microcapsules in a kind of feature according to claim 1, it is characterised in that：Described In plant blend oil, medium-chain fatty glyceride is coconut oil.
5. long-chain fat acid glyceride microcapsules in a kind of feature according to claim 1 or 2, it is characterised in that：Institute The weight of each raw material components is in the plant blend oil stated：Linseed oil 15, oil and fat of sacha inchi 2, Purple Perilla Seed Oil 23, tree peony Seed oil 2, Seabuckthorm Seed Oil 3, fiery flaxseed oil 8, Boxthorn Seed Oil 10, acer truncatum seed oil 1, pumpkin seed oil 12, evening primrose oil 5, the wooden fruit of breast Oil 3, coconut oil 17.
6. the plant blend oil of the scientific matching according to Claims 2 or 3, it is characterised in that the acid value of described grease≤ 1 （KOH mg/g）, peroxide value≤0.13（G/100g, with buttermeter）.
7. long-chain fat acid glyceride microcapsules in a kind of feature according to claim 1 or 2, it is characterised in that plant The preparation method of ready-mixed oil is as follows：Under nitrogen protective condition, each grease is proportionally added into blending tank, in temperature 35-40 °C, under condition of normal pressure, stirred 20-60 minutes with 60r/min speed, filtering, plant blend oil is obtained after standing.
8. according to claim 1, the lactoprotein in described wall material is that casein sodium, whey protein isolate, lactalbumin are dense One or more mixtures in contracting thing or soybean protein isolate；Wall material renovation agent in the wall material is the meals of small molecule One or more mixing in fiber, lactose, sucrose, trehalose, L-arabinose, D-sorbite, xylitol；Dietary fiber For resistant dextrin, inulin, stachyose, FOS, galactooligosaccharide, oligoisomaltose any combination；In the wall material Hydrophilic colloid be xanthans, flaxseed gum, pulullan polysaccharide, Arabic gum one or more mixing.
9. long-chain fat acid glyceride microcapsules in a kind of feature according to claim 1, it is characterised in that processing side Method is：
It is prepared by aqueous phase：First hydrophilic colloid, heat preservation for standby use are fully dissolved with 70 °C of part hot water；With part aqueous solution metal-chelating Agent, it is stand-by；With aqueous phase tank, lactoprotein, converted starch are charged first in 50-65 °C of hot water, are incubated, stirring is allowed to completely molten Solution, maltodextrin, malt syrup and wall material renovation agent are added, 50-65 °C of insulation, being sufficiently stirred mixes wall material dissolving, adds Enter pre- solvent hydrophilic colloid；Then it is cooled to 45-55 °C；Finally pre- solvent metal-chelator and aqueous phase antioxidant are added Enter into aqueous phase tank, obtain aqueous phase；
It is prepared by oil phase：First vegetable oil is reconciled and is added to oil phase tank, 50-65 °C is slowly heated to, first adds emulsifying agent, insulation makes Emulsifying agent is completely dissolved, and is then cooled to 40 °C, adds oil phase antioxidant, and stirring is allowed to fully dissolve, and obtains oil phase；
The preparation of colostric fluid：Aqueous phase is first pumped into emulsion tank, 48-52 °C of insulation, while opens stirring and high speed shear, then Oil phase is slowly added into emulsion tank, cuts 20-40 minutes at a high speed, and keeps -20--50mPa vacuum, obtains colostric fluid；
It is prepared by emulsion：Using secondary pressure homogenizer to colostric fluid carry out homogeneous, homogeneous 2-3 times, homogenization pressure 40-65Pa, Obtain emulsion；
Sterilizing：Using ultra high temperature short time sterilization machine to step（4）Obtained emulsion sterilizes 10-15s under 108-135 °C, discharging Temperature is 60-70 °C；
Spray drying：EAT is 165-180 °C, and leaving air temp is 85-90 °C, then passes through fluid bed and gathers again, obtains micro- Capsule powders；
Mixed powder sieving：Anticaking agent is added to step（6）In obtained microscapsule powder, it is well mixed, crosses 20 mesh or 40 mesh shake Dynamic sieve, obtained microcapsules；
Packaging：By step（7）Obtained microcapsules, load PE inner bags, first vacuumize, backfill nitrogen afterwards, by metal detection After instrument, load aluminium foil bag, obtain finished product；
Can be by step（8）Granule or capsule is made using conventional formulation method in gained microcapsules.
10. long-chain fat acid glyceride microcapsules in a kind of feature described in claim 9, it is characterised in that the step （1）Middle amount of water is calculated by emulsion solid content 30-45%；Temperature control is at 50-60 °C in homogenizing process；Thing after sterilizing It is 50-60 °C to expect temperature to be painted；Spray drying tower is upper air-out Spray Grain-make Drier, and atomizer is pressure atomizer；Go out Material after bacterium is forced into spray drying tower by high-pressure pump, and high pressure pump pressure is 8-15mPa；It it is 40-70 ° for fluidized-bed temperature C。
CN201710996359.2A 2017-10-24 2017-10-24 Long-chain fat acid glyceride microcapsules and its production method in a kind of feature Pending CN107712900A (en)

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Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101269310A (en) * 2008-05-06 2008-09-24 大连赛诺微囊技术有限公司 Method for preparing cold water dispersion type microcapsule powder
CN101647512A (en) * 2009-06-17 2010-02-17 新奥（厦门）农牧发展有限公司 Polyphyly fat mixture for feeding animals and microcapsule applying mixture
WO2011026612A1 (en) * 2009-09-02 2011-03-10 Lipofoods, S.L. Microcapsules containing salts for food products
CN102488088A (en) * 2011-11-14 2012-06-13 龙岩新奥生物科技有限公司 Medium-chain fatty glyceride and application thereof in microcapsules
CN102550817A (en) * 2011-12-31 2012-07-11 厦门金达威集团股份有限公司 Functional oil microencapsulation and manufacturing method thereof
CN102860506A (en) * 2012-08-08 2013-01-09 辽宁省大连海洋渔业集团公司 Krill oil microcapsual powder and its preparation method
CN106172876A (en) * 2014-09-09 2016-12-07 长谷川香料株式会社 For giving powdered oil compositions and the adding method thereof of breast local flavor
CN107105743A (en) * 2014-10-08 2017-08-29 雅培制药有限公司 Alimentation composition comprising oxidizable components and water soluble plant extract

Patent Citations (8)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101269310A (en) * 2008-05-06 2008-09-24 大连赛诺微囊技术有限公司 Method for preparing cold water dispersion type microcapsule powder
CN101647512A (en) * 2009-06-17 2010-02-17 新奥（厦门）农牧发展有限公司 Polyphyly fat mixture for feeding animals and microcapsule applying mixture
WO2011026612A1 (en) * 2009-09-02 2011-03-10 Lipofoods, S.L. Microcapsules containing salts for food products
CN102488088A (en) * 2011-11-14 2012-06-13 龙岩新奥生物科技有限公司 Medium-chain fatty glyceride and application thereof in microcapsules
CN102550817A (en) * 2011-12-31 2012-07-11 厦门金达威集团股份有限公司 Functional oil microencapsulation and manufacturing method thereof
CN102860506A (en) * 2012-08-08 2013-01-09 辽宁省大连海洋渔业集团公司 Krill oil microcapsual powder and its preparation method
CN106172876A (en) * 2014-09-09 2016-12-07 长谷川香料株式会社 For giving powdered oil compositions and the adding method thereof of breast local flavor
CN107105743A (en) * 2014-10-08 2017-08-29 雅培制药有限公司 Alimentation composition comprising oxidizable components and water soluble plant extract

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
何东平等: "《油脂工厂设计手册 上》", 31 August 2012, 湖北科学技术出版社 *

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