CN114515325B - 一种治疗慢性疼痛的苗药拔毒膏及其制备方法 - Google Patents
一种治疗慢性疼痛的苗药拔毒膏及其制备方法 Download PDFInfo
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Abstract
本发明公开了一种治疗慢性疼痛的苗药拔毒膏，本发明所述药物由糯竹炭，百草霜，珍陆，仰松芭，者学欧，乳香，没药，苍术，川芎，附子，细辛，凯访，甘草，竹沥制备而成。本发明具有行气活血，定痛消肿的功效，以治疗癌性疼痛、关节疼痛等慢性疼痛症状，适用于患有癌症或因远伤病而导致长期的人群。
Description
发明领域：
本发明涉及一种治疗慢性疼痛的苗药拔毒膏及其制备方法，属于药品、尤其是苗药技术的领域。
背景技术
慢性疼痛是指持续一个月以上(以前为三个月或半年)的疼痛，也有人把慢性疼痛比喻为一种不死的癌症。目前，中国至少有一亿以上的慢性疼痛患者。慢性疼痛是远伤病的一个主要症状，癌症疼痛也属于慢性疼痛的一种。慢性疼痛疾病的病理广泛存在于我们每一个人身体中。慢性疼痛的发生也预示人体体质下降或其他部位可能出现健康危机。由于它的发作给患者带来的痛楚，会使人出现睡眠紊乱、食欲缺乏、精神崩溃甚至人格扭曲和家居不宁等后果，致使不少病人因无法忍受长期的疼痛折磨而选择自杀。对老年人的生活和生命质量产生严重影响。
苗医源远流长，发展至今，苗家医药已经有三、四千年的历史。苗族的医药常常与神秘、神奇这样的词汇联系在一起，自成体系，尤以其内病外治的疗法闻名中外。苗族民间还有“千年苗医，万年苗药”之说。苗医认为一个人身体某部位、或心理或精神抵御不住过量的负荷，必然会导致气血、经络的运动不正常，产生疼痛难受的现象，而治病就是要采取种种手段使气血、经络疏通，恢复正常，达到疼痛消除，各个器官发挥正常功能的目的。而苗医所称的“两纲”即“冷病热治、热病冷治”，是他们治病的两大法则，具体治法则分内治法和外治法，其外治法尤为丰富，并体现了浓郁的民族特色和治疗特点。本申请采取膏药外敷的方法，使用行气活血，定痛消肿的药物，以治疗癌性疼痛、关节疼痛等慢性疼痛症状。适用于患有癌症或因远伤病而导致长期的人群。
发明内容
本发明所要解决的技术问题在于提供慢性疼痛的苗药拔毒膏及其制备方法。本发明本发明具有行气活血，定痛消肿的功效，以治疗癌性疼痛、关节疼痛等慢性疼痛症状。适用于患有癌症或因远伤病而导致长期的人群。
为解决以上技术问题，本发明采用以下技术方案实现：
一种治疗慢性疼痛的苗药拔毒膏，其药用有效成分按照重量组分计算：由糯竹炭500-1500份，百草霜500-1500份，珍陆500-1500 份，仰松芭500-1500份，者学欧500-1500份，乳香500-1500份，没药500-1500份，苍术500-1500份，川芎500-1500份，附子250-750份，细辛250-750份，凯访500-1500份，甘草500-1500份，竹沥 500-1500份制备而成。
具体的说，所述的治疗慢性疼痛的苗药拔毒膏，其药用有效成分按照重量组分计算：由糯竹炭750-1250份，百草霜750-1250份，珍陆750-1250份，仰松芭750-1250份，者学欧750-1250份，乳香 750-1250份，没药750-1250份，苍术750-1250份，川芎750-1250 份，附子350-650份，细辛350-650份，凯访750-1250份，甘草 750-1250份，竹沥750-1250份制备而成。
更具体的说，所述的治疗慢性疼痛的苗药拔毒膏，其药用有效成分按照重量组分计算：由糯竹炭1000份，百草霜1000份，珍陆1000 份，仰松芭1000份，者学欧1000份，乳香1000份，没药1000份，苍术1000份，川芎1000份，附子500份，细辛500份，凯访1000 份，甘草1000份，竹沥1000份制备而成。
前述治疗慢性疼痛的苗药拔毒膏的制备方法为：按照比例称取方中所有药材，并按照常规的制备方法进行加工，制成相应的药物制剂。
具体地说，前述治疗慢性疼痛的苗药拔毒膏的制备方法为：按照比例称取方中所有药材(除竹沥外)，将其粉碎后混合均匀后,按照常规的制备方法进行加工，加入竹沥液及适量水调成膏状，即得。
所述药物制剂为膏剂、硬膏剂。
所述膏剂这样制备：按照比例称取方中所有药材(除竹沥外)，将其粉碎成80目细粉后混合均匀，灭菌后打包备用，另取竹沥液灭菌密封后备用，使用前取药粉与处理过的竹沥液及适量水调成膏状，即得。
所述凝胶膏剂这样制备：按照处方比例称取各药材(除竹沥外)，将其粉碎成80目细粉后，加8倍量水提取3次，每次1小时三次提取液液合并，混匀，浓缩成原药液的80％时，趁热过滤，滤液浓缩至 80℃时相对密度为1.20-1.30的浸膏，加入竹沥混悬均匀,作为B相；另取10％聚丙烯酸钠、5％羟苯乙酯乙醇溶液、5％亚硫酸钠水溶液、2％微粉硅胶混合均匀后加入20％甘油,作为A相；将B相倒入A相中,用中药成型实验机压制得到平整的贴剂,分割成8cm×10cm的贴剂，即得。
与现有技术相比，本发明具有以下有益效果：
本发明所述治疗慢性疼痛的苗药拔毒膏由糯竹炭，百草霜，珍陆，仰松芭，者学欧，乳香，没药，苍术，川芎，附子，细辛，凯访，甘草，竹沥制成制备而成。各成分性质及功效如下：糯竹炭( Cephalostachyum pergracile Munro Charcoal，糯竹炭)是以三年生以上高山毛竹为原料，经近千度高温烧制而成的一种炭；具有促进人体血液循环和新陈代谢，缓解疲劳。百草霜(Fuligo Plantae，锅底灰)为杂草经燃烧后附于锅底或烟筒中所存的烟墨，可药用。味辛，性温；归肝、肺、胃经；具有敛营止血，清热消瘀的功效；主治吐血、衄血、便血、血崩、带下、食积、痢疾、黄疸、咽喉肿痛、口舌生疮、臁疮、白秃头疮、外伤出血。珍陆(又名栀子)为茜草科植物扼子Gardenia jasminoides Ellis的干燥成熟果实；
果实成熟呈红黄色时采收，除去果梗和杂质，蒸至上气或置沸水中略烫，取出，干燥；性冷，味苦，属冷药，入热经；具有泻火除烦，清热利湿，凉血解毒；外用消肿止痛的功效；用于热病心烦，湿热黄疸，淋证涩痛，血热吐衄，目赤肿痛，火毒疮疡；外治扭挫伤痛。仰松芭(又名香附)为莎草科植物莎草Cyperus rotundus L.的干燥根茎；秋季采挖，燎去毛须，置沸水中略煮或蒸透后晒干，或燎后直接晒干；性热，味微甜，属热药，入冷经；具有疏肝解郁，理气宽中，调经止痛的功效；用于肝郁气滞，胸胁胀痛，疝气疼痛，乳房胀痛，脾胃气滞，脘腹痞闷，胀满疼痛，月经不调，经闭痛经。者学欧(又名红花)为菊科植物红花 Carthamus tinctorius L.的干燥花。夏季花由黄变红时釆摘，阴干或晒干；性热，味苦，属热药，入冷经；具有养血活血、活血祛瘀、养血行血的功效；用于经闭，痛经，恶露不行，癥痕痞块，胸痹心痛，瘀滞腹痛，胸胁刺痛，跌扑损伤，疮疡肿痛。乳香为橄榄科植物乳香树Boswellia carterii Birdw.及同属植物Boswellia bhaw dajiana Birdw.树皮渗出的树脂分为索马里乳香和埃塞俄比亚乳香，每种乳香又分为乳香珠和原乳香；味辛、苦，性温；归心、肝、脾经；具有活血定痛，消肿生肌的功效；用于胸痹心痛，胃脘疼痛，痛经经闭，产后瘀阻，癥瘕腹痛，风湿痹痛，筋脉拘挛，跌打损伤，痈肿疮疡。没药为橄榄科植物地丁树Commiphora myrrha Engl.或哈地丁树Commiphora molmol Engl.的干燥树脂；分为天然没药和胶质没药；味辛、苦，性平；归心、肝、脾经；具有散瘀定痛，消肿生肌的功效；用于胸痹心痛，胃脘疼痛，痛经闭经，产后瘀阻，癥瘕腹痛，风湿痹痛，跌打损伤，痈肿疮疡。苍术为菊科植物茅苍术Atractylodes lancea(Thunb.)DC.或北苍术Atractylodes chinensis(DC.)Koidz.的干燥根茎；舂、秋二季采挖，除去泥沙，晒干，撞去须根；味辛、苦，性温；归脾、胃、肝经；具有燥湿徤脾，祛风散寒，明目的功效；用于湿阻中焦，脘腹胀满，泄泻，水肿，脚气痿蹵，风湿痹痛，风寒感冒，夜盲，眼目昏涩。川芎为伞形科植物川芎Ligusticum chuanxiong Hort.的干燥根茎；夏季当茎上的节盘显著突出，并略带紫色时采挖，除去泥沙，晒后烘干，再去须根；味辛，性温；归肝、胆、心包经；具有活血行气，祛风止痛的功效；用于胸痹心痛，胸胁刺痛，跌扑肿痛，月经不调，经闭痛经，癥瘕腹痛，头痛，风湿痹痛。附子为毛茛科植物乌头Aconitum carmichaelii Debx.的子根的加工品；味辛、甘，性大热，有大毒；归心、肾、脾经；具有回阳救逆，补火助阳，散寒止痛的功效；用于亡阳虛脱，肢冷脉微，心阳不足，胸痹心痛，虛寒吐泻，脘腹冷痛，肾阳虛衰，阳痿宫冷，阴寒水肿，阳虚外感，寒湿痹痛。细辛为马觉铃科植物北细辛Asarumheterotropoides Fr.Schmidt var.man dshuricum(Maxim.)Kitag.、汉城细辛Asarumsieboldii Miq.var.seoulense Nakai或华细辛 Asarwm sieboldii Miq.的干燥根和根莲；前二种习称“辽细辛”；夏季果熟期或初秋采挖，除净地上部分和泥沙，阴干；味辛，性温；归心、肺、肾经；具有解表散寒，祛风止痛，通窍止痛，温肺化饮的功效；用于风寒感冒，头痛，牙痛，鼻塞流涕，鼻鼽，鼻渊，风湿痹痛，痰饮喘咳。凯访(又名姜黄)为姜科植物姜黄CurcumaLonga L.的干燥根茎。冬季茎叶枯萎时釆挖，洗净，煮或蒸至透心，晒干，除去须根；性冷，味辣、麻，带苦，属冷药，入热经；具有行气止痛，行气破瘀，通络止痛的功效；用于胸胁刺痛，胸痹心痛，痛经经闭，癥瘕，风湿肩臂疼痛，跌扑肿痛。甘草为豆科植物甘草Glycyrrhizauralensis Fisch.胀果甘草Glycyrrhiza inflata Bat.或光果甘草Glycyrrhiza glabraL.的干燥根和根茎；春、秋二季采挖，除去须根，晒干；味甘，性平；归心、肺、脾、胃经；具有补脾益气，淸热解毒，祛痰止咳，缓急止痛，调和诸药的功效；用于脾胃虚弱，倦怠乏力，心悸气短，咳嗽痰多, 脘腹、四肢挛急疼痛，痈肿疮毒,
缓解药物毒性、烈性。竹沥为禾本科植物淡竹 Phyllostachysnigra(Lodd.exLindl.)Munrovar.henonis(Mitf.)StapfetRendle 等的茎经火烤后所流出的液汁；味甘、苦，性寒；归心、肝、肺经；具有清肺降火，滑痰利窍的功效；用于中风痰迷，肺热痰壅，惊风，癫痫，热病痰多，壮热烦渴，子烦，破伤风。
方解：百草霜，性辛，温，归肝、肺、胃经，敛营止血，清热消瘀；珍陆(栀子)，性冷，味苦，属冷药，入热经，平肝泻火，泻火解毒，清热利湿；仰松芭(香附)，性热，味微甜，属热药，入冷经，理气疏肝止痛。者学欧(红花)，性热，味苦，属热药，入冷经，养血活血、活血祛瘀、养血行血；乳香，性温，味辛、苦，归心经、脾经、肝经，调气活血、定痛、消肿、生肌；没药，性苦、辛、平，入肝经，散血止痛，消肿生肌；岩川芎，性温，味甘、咸，归肝、肾经，行气止痛。附子，性热，味辛、甘，有大毒。归心经、肾经、脾经，回阳救逆，补火助阳，散寒止痛；细辛，性温，味辛。归心经、肺经、肾经，祛风、散寒、通窍止痛、温肺祛痰；凯访(姜黄)，性冷，味辣、麻，带苦，属冷药，入热经，行气止痛，行气破瘀，通络止痛。甘草，性平，味甘，归心经、胃经、脾经、肺经，补脾益气、止咳祛痰、缓急定痛、调和药性；竹沥，性寒，味甘、苦，归心经、肝经、肺经，清热降火，滑痰利窍。
与现有技术相比，本发明选用糯竹炭，百草霜，珍陆，仰松芭，者学欧，乳香，没药，苍术，川芎，附子，细辛，凯访，甘草，竹沥组方，具有行气活血，定痛消肿的功效，以治疗癌性疼痛、关节疼痛等慢性疼痛症状，适用于患有癌症或因远伤病而导致长期的人群。
具体实施方式
下面结合实施例对本发明作进一步的说明，但并不作为对本发明限制的依据。
实施例1。
处方：糯竹炭1500g，百草霜1500g，珍陆1500g，仰松芭1500g，者学欧1500g，乳香1500g，没药1500g，苍术1500g，川芎1500g，附子750g，细辛750g，凯访1500g，甘草1500g，竹沥1500g制成。
工艺：按照比例称取方中所有药材(除竹沥外)，将其粉碎成 80目细粉后混合均匀，灭菌后打包备用，另取竹沥液灭菌密封后备用，使用前取药粉与处理过的竹沥液及适量水调成膏状，即得膏剂。
用法用量：将膏状敷患处，每天一次。
实施例2。
处方：糯竹炭500g，百草霜500g，珍陆500g，仰松芭500g，者学欧500g，乳香500g，没药500g，苍术500g，川芎500g，附子250g，细辛250g，凯访500g，甘草500g，竹沥500g制成。
工艺：所述这样制备：按照处方比例称取各药材(除竹沥外)，将其粉碎成80目细粉后，加8倍量水提取3次，每次1小时三次提取液液合并，混匀，浓缩成原药液的80％时，趁热过滤，滤液浓缩至 80℃时相对密度为1.20-1.30的浸膏，加入竹沥混悬均匀,作为B相；另取10％聚丙烯酸钠、5％羟苯乙酯乙醇溶液、5％亚硫酸钠水溶液、2％微粉硅胶混合均匀后加入20％甘油,作为A相；将B相倒入A相中,用中药成型实验机压制得到平整的贴剂,分割成8cm×10cm的贴剂，即得凝胶膏剂。
用法用量：将膏状敷患处，每12小时一次。
实施例3。
处方：糯竹炭1000g，百草霜1000g，珍陆1000g，仰松芭1000g，者学欧1000g，乳香1000g，没药1000g，苍术1000g，川芎1000g，附子500g，细辛500g，凯访1000g，甘草1000g，竹沥1000g制成。
工艺：按照比例称取方中所有药材(除竹沥外)，将其粉碎成 80目细粉后混合均匀，灭菌后打包备用，另取竹沥液灭菌密封后备用，使用前取药粉与处理过的竹沥液及适量水调成膏状，。
用法用量：将膏状敷患处，每天一次。
实施例4。
处方：糯竹炭1500g，百草霜800g，珍陆1000g，仰松芭700g，者学欧1200g，乳香800g，没药1000g，苍术1500g，川芎500g，附子400g，细辛350g，凯访800g，甘草1350g，竹沥850g制成。
工艺：所述这样制备：按照处方比例称取各药材(除竹沥外)，将其粉碎成80目细粉后，加6倍量水提取3次，每次1.5小时三次提取液液合并，混匀，浓缩成原药液的80％时，趁热过滤，滤液浓缩至80℃时相对密度为1.20-1.30的浸膏，加入竹沥混悬均匀,作为B 相；另取10％聚丙烯酸钠、5％羟苯乙酯乙醇溶液、5％亚硫酸钠水溶液、 2％微粉硅胶混合均匀后加入20％甘油,作为A相；将B相倒入A相中, 用中药成型实验机压制得到平整的贴剂,分割成8cm×10cm的贴剂，即得凝胶膏剂。
用法用量：将膏状敷患处，每12小时一次。
实施例5。
处方：糯竹炭1100g，百草霜600g，珍陆550g，仰松芭950g，者学欧750g，乳香1500g，没药1000g，苍术500g，川芎700g，附子750g，细辛350g，凯访1400g，甘草1200g，竹沥1050g制成。
工艺：按照比例称取方中所有药材(除竹沥外)，将其粉碎成 80目细粉后混合均匀，灭菌后打包备用，另取竹沥液灭菌密封后备用，使用前取药粉与处理过的竹沥液及适量水调成膏状，即得膏剂。
用法用量：将膏状敷患处，每天一次。
实施例6。
处方：糯竹炭700g，百草霜850g，珍陆700g，仰松芭900g，者学欧1500g，乳香500g，没药1100g，苍术1450g，川芎1000g，附子250g，细辛650g，凯访600g，甘草550g，竹沥500g制成。
工艺：所述这样制备：按照处方比例称取各药材(除竹沥外)，将其粉碎成80目细粉后，加10倍量水提取2次，每次2小时两次提取液液合并，混匀，浓缩成原药液的80％时，趁热过滤，滤液浓缩至 80℃时相对密度为1.20-1.30的浸膏，加入竹沥混悬均匀,作为B相；另取10％聚丙烯酸钠、5％羟苯乙酯乙醇溶液、5％亚硫酸钠水溶液、2％微粉硅胶混合均匀后加入20％甘油,作为A相；将B相倒入A相中,用中药成型实验机压制得到平整的贴剂,分割成8cm×10cm的贴剂，即得凝胶膏剂。
用法用量：将膏状敷患处，每12小时一次。
本发明进行了大量的实验研究，以下为本发明实验研究的结果：
实验例：药效学研究
实验例1药效实验
1材料
1.1仪器设备辐射热敏刺激仪(浙江大学国家光学仪器工程技术研究中心研制)，Von Frey纤毛机械刺激仪(美国Northcoast medical 公司)。
1.2实验动物和细胞：雄性SD大鼠80只，体质量250～300g；大鼠Walker256乳腺癌细胞系。
1.3处理药物：本发明药物，按照实施例1、2、3、4、5、6分别进行；对照药物：硫酸吗啡。
2建立骨癌痛动物模型：将Walker256乳腺癌细胞注射到SD大鼠腹腔进行细胞培养，收集大量腹水，离心腹水收集细胞。参照Medhurst 等的方法建立模型。对大鼠进行腹腔注射麻醉后，将其仰卧位固定于操作台上。将大鼠左侧小腿胫骨部位剃毛、消毒，切开皮肤，分离肌肉并暴露胫骨下段，使用20ml注射器针头穿刺打孔，然后用10μl微量注射器将Walker256乳腺癌细胞缓慢注入骨髓腔，注射后迅速用骨蜡封闭钻孔处，尔后用75％酒精消毒伤口，逐层缝合伤口。术后观察每只大鼠的一般情况、进食、体质量、活动及胫骨局部变化，5d用于实验。
3动物模型分组和给药：成功构建骨癌痛模型大鼠共80只。将所有大鼠背毛除去，待大鼠休息5d后随机分为8组，每组10只，本发明组(实施例1、2、3、4、5、6)；硫酸吗啡组；空白对照组。
空白对照组：背部除毛后外敷与癌痛贴面积相同大小的空白医用胶布，再立即腹腔注射10mL/kg 0.7％的冰醋酸；硫酸吗啡组：腹腔注射20mg/kg硫酸吗啡后，再腹腔注射10mL/kg 0.7％的冰醋酸；本发明药物组：背部除毛后，外敷本发明药，给药30min后，再腔注射 10mL/kg 0.7％的冰醋酸。分别与建模后3、7、10d用Von Frey法检测大鼠给药后1h的机械缩爪反射阈值(MWT)，反映机械性痛觉过敏程度；用Harg-reaves法测定热刺激缩爪反应潜伏期(TWL)，反映热痛觉过敏程度。
4统计学方法：结果数据以均数±标准差(x±s)表示，应用SPSS22.0 软件统计分析，两两比较采用Dunnett.t检验，组间比较采用单因素方差分析。
5结果见表1、表2。
表1各种处理方法对骨癌痛模型大鼠MWT的影响
表2各种处理方法对骨癌痛模型大鼠TWL的影响
结果表明：本发明实施例各组大鼠的MWT明显增加，TWL明显延长(P<0.05)，本发明药物能有效治疗癌肿所致的慢性疼痛。
实验例2毒性试验
1试验动物：健康、皮肤无损的新西兰大白兔，体重2.0-3.0kg。
2试验环境和条件：贵州医科大学实验动物中心：SCXX(黔) 2012-0001；实验动物使用许可证：SYXK(黔)2014-001。温度： 18-23℃，湿度：40％-70％，饲养条件：单笼饲养。
3样品处理：将本发明所述药物实施例1和实施例2，按比例混合后，用适量温水调匀备用。
4试验方法：试验动物检疫3天后，选用健康、成年、皮肤无损的新西兰大白兔8只，每组实施例4只。试验前24h，将试验动物背部脊柱两侧被毛除去，切勿损伤表皮，去毛范围为每处3cm*3cm。分别取所述实施例1和实施例2本发明药物0.5g涂抹于脊柱一侧去毛皮肤上，涂抹面积为2.5*2.5cm，另一侧作为对照，每天涂抹一次，连续涂抹14d。从第二次涂抹开始，每次涂抹前剪毛，并用温水清楚残留药物，1h后观察结果，同时观察除外刺激性以外的其他毒性作用。皮肤刺激反应平均分值＝(红斑总分+水肿总分)/动物总数。《皮肤刺激性强度评价标准》中皮肤刺激性反应平均分值在0～0.49分、0.50～ 2.99分、3.00～5.99分、6.00～8.00分别代表“无刺激性”“轻度刺激性”“中度刺激性”和“强刺激性”。
5结果见表3，表4。
表3本发明药实施例1皮肤刺激性试验结果
表4本发明药实施例2皮肤刺激性试验结果
6结论：本发明药物多次皮肤刺激试验的皮肤反应积分平均值为无刺激性，本发明药物多次皮肤刺激试验属无刺激性。
Claims (9)
1.一种治疗慢性疼痛的苗药拔毒膏，其特征在于：原料药按重量组分计算如下：由糯竹炭500-1500份，百草霜500-1500份，栀子500-1500份，香附500-1500份，红花500-1500份，乳香500-1500份，没药500-1500份，苍术500-1500份，川芎500-1500份，附子250-750份，细辛250-750份，姜黄500-1500份，甘草500-1500份，竹沥500-1500份制成。
2.如权利要求1所述的治疗慢性疼痛的苗药拔毒膏，其特征在于：原料药按重量组分计算如下：由糯竹炭750-1250份，百草霜750-1250份，栀子750-1250份，香附750-1250份，红花750-1250份，乳香750-1250份，没药750-1250份，苍术750-1250份，川芎750-1250份，附子350-650份，细辛350-650份，姜黄750-1250份，甘草750-1250份，竹沥750-1250份制成。
3.如权利要求1或2所述的治疗慢性疼痛的苗药拔毒膏，其特征在于：原料药按重量组分计算如下：由糯竹炭1000份，百草霜1000份，栀子1000份，香附1000份，红花1000份，乳香1000份，没药1000份，苍术1000份，川芎1000份，附子500份，细辛500份，姜黄1000份，甘草1000份，竹沥1000份制成。
4.如权利要求1-3中任意一项所述治疗慢性疼痛的苗药拔毒膏的制备方法，其特征在于：按照比例称取方中所有药材，并按照常规的制备方法进行加工，制成相应的药物制剂。
5.如权利要求4所述治疗慢性疼痛的苗药拔毒膏的制备方法，其特征在于：按照比例称取方中除竹沥外的所有药材，将其粉碎后混合均匀后,按照常规的制备方法进行加工，加入竹沥液及适量水调成膏状，即得。
6.如权利要求5所述治疗慢性疼痛的苗药拔毒膏的制备方法，
其特征在于：所述药物制剂为膏剂。
7.如权利要求6所述治疗慢性疼痛的苗药拔毒膏的制备方法，
其特征在于：所述膏剂为凝胶膏剂。
8.如权利要求6所述治疗慢性疼痛的苗药拔毒膏的制备方法，其特征在于：所述膏剂这样制备：按照比例称取除竹沥外的其他药材，将其粉碎成80目细粉后混合均匀，灭菌后打包备用，另取竹沥液灭菌密封后备用，使用前取药粉与处理过的竹沥液及适量水调成膏状，即得。
9.如权利要求7所述治疗慢性疼痛的苗药拔毒膏的制备方法，其特征在于：所述凝胶膏剂这样制备：按照比例称取除竹沥外的其他药材，将其粉碎成80目细粉后，加8倍量水提取3次，每次1小时三次提取液液合并，混匀，浓缩成原药液的80%时，趁热过滤，滤液浓缩至80℃时相对密度为1.20-1.30的浸膏，加入竹沥混悬均匀,作为B相；另取10%聚丙烯酸钠、5%羟苯乙酯乙醇溶液、5%亚硫酸钠水溶液、2%微粉硅胶混合均匀后加入20%甘油,作为A相；将B相倒入A相中,用中药成型实验机压制得到平整的贴剂,分割成8cm×10cm的贴剂，即得。
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